hydrogen

Summary

Summary: Hydrogen. The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight 1. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.

Top Publications

  1. pmc Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
    Jane M Carlton
    Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
    Science 315:207-12. 2007
  2. doi Radioprotective effect of hydrogen in cultured cells and mice
    Liren Qian
    Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, PR China
    Free Radic Res 44:275-82. 2010
  3. doi Enhanced hydrogen evolution catalysis from chemically exfoliated metallic MoS2 nanosheets
    Mark A Lukowski
    Department of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States
    J Am Chem Soc 135:10274-7. 2013
  4. doi Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury
    Kentaro Hayashida
    Division of Cardiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 373:30-5. 2008
  5. doi Hydrogen is an energy source for hydrothermal vent symbioses
    Jillian M Petersen
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, 28359 Bremen, Germany
    Nature 476:176-80. 2011
  6. doi Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model
    Jianmei Cai
    Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China
    Brain Res 1256:129-37. 2009
  7. ncbi Occurrence, classification, and biological function of hydrogenases: an overview
    Paulette M Vignais
    CEA Grenoble, Laboratoire de Biochimie et Biophysique des Systemes Integres, UMR CEA CNRS UJF 5092, Institut de Recherches en Technologies et Sciences pour le Vivant iRTSV, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    Chem Rev 107:4206-72. 2007
  8. ncbi Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated bacterial phyla
    Kelly C Wrighton
    Department of Earth and Planetary Science, University of California, Berkeley, Berkeley, CA 94720, USA
    Science 337:1661-5. 2012
  9. doi Microbiota-derived hydrogen fuels Salmonella typhimurium invasion of the gut ecosystem
    Lisa Maier
    Institute of Microbiology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell Host Microbe 14:641-51. 2013
  10. doi Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress
    Jian Li
    Department of Neurology, The First Affiliated Hospital of China Medical University, Shengyang, PR China
    Brain Res 1328:152-61. 2010

Detail Information

Publications327 found, 100 shown here

  1. pmc Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
    Jane M Carlton
    Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
    Science 315:207-12. 2007
    ..The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria...
  2. doi Radioprotective effect of hydrogen in cultured cells and mice
    Liren Qian
    Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, PR China
    Free Radic Res 44:275-82. 2010
    It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro...
  3. doi Enhanced hydrogen evolution catalysis from chemically exfoliated metallic MoS2 nanosheets
    Mark A Lukowski
    Department of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States
    J Am Chem Soc 135:10274-7. 2013
    Promising catalytic activity from molybdenum disulfide (MoS2) in the hydrogen evolution reaction (HER) is attributed to active sites located along the edges of its two-dimensional layered crystal structure, but its performance is ..
  4. doi Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury
    Kentaro Hayashida
    Division of Cardiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 373:30-5. 2008
    Inhalation of hydrogen (H(2)) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents...
  5. doi Hydrogen is an energy source for hydrothermal vent symbioses
    Jillian M Petersen
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, 28359 Bremen, Germany
    Nature 476:176-80. 2011
    ..we show here that the symbionts of the hydrothermal vent mussel Bathymodiolus from the Mid-Atlantic Ridge use hydrogen to power primary production...
  6. doi Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model
    Jianmei Cai
    Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China
    Brain Res 1256:129-37. 2009
    ..This study aimed to examine the short and long-term neuroprotective effect of hydrogen saline (H(2) saline) using an established neonatal HI rat pup model...
  7. ncbi Occurrence, classification, and biological function of hydrogenases: an overview
    Paulette M Vignais
    CEA Grenoble, Laboratoire de Biochimie et Biophysique des Systemes Integres, UMR CEA CNRS UJF 5092, Institut de Recherches en Technologies et Sciences pour le Vivant iRTSV, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    Chem Rev 107:4206-72. 2007
  8. ncbi Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated bacterial phyla
    Kelly C Wrighton
    Department of Earth and Planetary Science, University of California, Berkeley, Berkeley, CA 94720, USA
    Science 337:1661-5. 2012
    ..For six organisms, the UGA stop codon is translated as tryptophan. All bacteria studied here may play previously unrecognized roles in hydrogen production, sulfur cycling, and fermentation of refractory sedimentary carbon.
  9. doi Microbiota-derived hydrogen fuels Salmonella typhimurium invasion of the gut ecosystem
    Lisa Maier
    Institute of Microbiology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell Host Microbe 14:641-51. 2013
    ..Tm) in the unperturbed gut is powered by S. Tm hyb hydrogenase, which facilitates consumption of hydrogen (H2), a central intermediate of microbiota metabolism...
  10. doi Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress
    Jian Li
    Department of Neurology, The First Affiliated Hospital of China Medical University, Shengyang, PR China
    Brain Res 1328:152-61. 2010
    This study is to examine if hydrogen-rich saline reduced amyloid beta (Abeta) induced neural inflammation, and learning and memory deficits in a rat model...
  11. pmc Carbon dioxide fixation as a central redox cofactor recycling mechanism in bacteria
    James B McKinlay
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:11669-75. 2010
    ..Some nonphotosynthetic heterotrophic bacteria have Calvin cycle genes, and their potential to use CO(2) fixation to recycle reduced cofactors deserves closer scrutiny...
  12. doi Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models
    Gerald A Matchett
    Department of Anesthesiology, Loma Linda University, Loma Linda, California, USA
    Brain Res 1259:90-7. 2009
    b>Hydrogen gas (H(2)) has been shown to ameliorate brain injury in experimental adult rat focal ischemia and in a mild neonatal hypoxia-ischemia (HI, 90 min hypoxia) rat model...
  13. doi Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance
    Sizuo Kajiyama
    Kajiyama Clinic, Kyoto 615 0035, Japan
    Nutr Res 28:137-43. 2008
    ..It is well established that hydrogen has a reducing action...
  14. pmc Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model
    C H Chen
    Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, USA
    Neuroscience 169:402-14. 2010
    ..In this study, we tested the effect of hydrogen gas on hemorrhagic transformation in a rat focal cerebral ischemia model...
  15. ncbi Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress
    Kei ichi Fukuda
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki, Kanagawa 211 8533, Japan
    Biochem Biophys Res Commun 361:670-4. 2007
    We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen gas decreases cerebral infarction volume by ..
  16. doi Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice
    Kazufumi Nagata
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Nakahara ku, Kawasaki, Japan
    Neuropsychopharmacology 34:501-8. 2009
    We have reported that hydrogen (H(2)) acts as an efficient antioxidant by gaseous rapid diffusion...
  17. doi Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats
    Yan Fei Mao
    Department of Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, PR China
    Biochem Biophys Res Commun 381:602-5. 2009
    b>Hydrogen has been reported to selectively reduce the hydroxyl radical, the most cytotoxic of reactive oxygen species...
  18. doi Oral hydrogen water prevents chronic allograft nephropathy in rats
    Jon S Cardinal
    Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    Kidney Int 77:101-9. 2010
    ..As molecular hydrogen gas can act as a scavenger of ROS, we tested the effect of treatment with hydrogen water (HW) in a model of ..
  19. pmc Ligand-enabled reactivity and selectivity in a synthetically versatile aryl C-H olefination
    Dong Hui Wang
    Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 327:315-9. 2010
    ..introduction of a halide onto an arene is not always straightforward, direct olefination of aryl carbon-hydrogen (C-H) bonds would obviate the inefficiencies associated with generating halide precursors or their equivalents...
  20. doi Molecular hydrogen and radiation protection
    Yunhai Chuai
    Department of Radiation Medicine, Second Military Medical University, Shanghai, China
    Free Radic Res 46:1061-7. 2012
    Molecular hydrogen (dihydrogen, H(2)) acts as a therapeutic antioxidant by selectively reducing hydroxyl radicals (•OH) and peroxynitrite (ONOO-)...
  21. doi Role of hydrogen in chemical vapor deposition growth of large single-crystal graphene
    Ivan Vlassiouk
    Measurement Science and System Engineering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    ACS Nano 5:6069-76. 2011
    ..graphene chemical vapor deposition growth on copper foil using methane as a carbon source is strongly affected by hydrogen, which appears to serve a dual role: an activator of the surface bound carbon that is necessary for monolayer ..
  22. doi Biological hydrogen production: prospects and challenges
    Hyung Sool Lee
    Center for Environmental Biotechnology, Biodesign Institute at Arizona State University, P O Box 875701, Tempe, AZ 85287 5701, USA
    Trends Biotechnol 28:262-71. 2010
    b>Hydrogen gas provides exceptional value as an energy carrier and industrial feedstock, but currently is produced entirely by reforming fossil fuels...
  23. doi Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion
    Yufeng Zhang
    Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China
    Int J Cardiol 148:91-5. 2011
    To study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R).
  24. doi Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate
    Mikihito Kajiya
    Department of Immunology, The Forsyth Institute, Boston, MA 02115, USA
    Biochem Biophys Res Commun 386:11-5. 2009
    By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion...
  25. doi Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury
    Hideaki Oharazawa
    Department of Ophthalmology, Musashikosugi Hospital, Nippon Medical School, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 51:487-92. 2010
    ..Study results have indicated that molecular hydrogen (H(2)) is an efficient antioxidant gas that selectively reduces the hydroxyl radical (*OH) and suppresses ..
  26. doi Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?
    Yoshihiko Suzuki
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City, Japan
    FEBS Lett 583:2157-9. 2009
    ..Our hypothesis is based on our recent discovery that H(2) acts as a unique antioxidant, and that when inhaled or taken orally as H(2)-dissolved water it ameliorates ischaemia-reperfusion injury and atherosclerosis development...
  27. doi Hydrogen exchange mass spectrometry for studying protein structure and dynamics
    Lars Konermann
    Department of Chemistry, The University of Western Ontario, London, ON N6A 5B7, Canada
    Chem Soc Rev 40:1224-34. 2011
    b>Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) has become a key technique for monitoring structural and dynamic aspects of proteins in solution...
  28. doi Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury
    B M Buchholz
    Division of Gastroenterology, Department of Medicine, Hepatology and Nutrition, Thomas E Starzi Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 8:2015-24. 2008
    ..Recent evidence indicates hydrogen inhalation eliminates toxic hydroxyl radicals...
  29. pmc Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Japan
    Curr Pharm Des 17:2241-52. 2011
    ..We have proposed that molecular hydrogen (H(2)) has potential as a "novel" antioxidant in preventive and therapeutic applications [Ohsawa et al., Nat Med...
  30. doi Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease
    Yuan Fu
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurosci Lett 453:81-5. 2009
    Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but not the other reactive oxygen and nitrogen species...
  31. ncbi Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy
    Horacio E Cingolani
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Calle 60 y 120, 1900 La Plata, Argentina
    Circulation 115:1090-100. 2007
  32. ncbi The potential cardioprotective effects of hydrogen in irradiated mice
    Liren Qian
    Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, PR China
    J Radiat Res 51:741-7. 2010
    Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease...
  33. pmc Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange
    Vytautas Smirnovas
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA
    Nat Struct Mol Biol 18:504-6. 2011
    ..Here we used mass spectrometry analysis of hydrogen-deuterium exchange to examine brain-derived PrP(Sc)...
  34. pmc Physiological characteristics of the extreme thermophile Caldicellulosiruptor saccharolyticus: an efficient hydrogen cell factory
    Karin Willquist
    Applied Microbiology, Lund University, Getingevagen 60, SE 222 41 Lund, Sweden
    Microb Cell Fact 9:89. 2010
    ..Biological hydrogen production from hemicellulose-containing waste is considered one of the promising avenues...
  35. doi Photobiological production of hydrogen gas as a biofuel
    James B McKinlay
    Department of Microbiology, University of Washington, Seattle, WA 98195, United States
    Curr Opin Biotechnol 21:244-51. 2010
    Solar energy can be converted into chemical energy in the form of hydrogen gas using oxygenic and anoxygenic photosynthetic microbes...
  36. doi Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 8533, Japan
    Biochem Biophys Res Commun 377:1195-8. 2008
    ..We have found that hydrogen (dihydrogen; H(2)) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K...
  37. pmc Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    Kyota Fujita
    Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 4:e7247. 2009
    It has been shown that molecular hydrogen (H(2)) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress...
  38. ncbi Microbial fuel cells: methodology and technology
    Bruce E Logan
    Hydrogen Energy Center, 212 Sackett Building, Penn State University, University Park, Pennsylvania 16802, USA
    Environ Sci Technol 40:5181-92. 2006
    ....
  39. doi Recent advances in hydrogen research as a therapeutic medical gas
    Chien Sheng Huang
    Department of Surgery, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taiwan
    Free Radic Res 44:971-82. 2010
    Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs...
  40. pmc Efficient degradation of lignocellulosic plant biomass, without pretreatment, by the thermophilic anaerobe "Anaerocellum thermophilum" DSM 6725
    Sung Jae Yang
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Appl Environ Microbiol 75:4762-9. 2009
    ..The predominant end products from all growth substrates were hydrogen, acetate, and lactate...
  41. doi Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells
    Tomohiro Itoh
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu, Japan
    Biochem Biophys Res Commun 389:651-6. 2009
    Molecular hydrogen ameliorates oxidative stress-associated diseases in animal models. We found that oral intake of hydrogen-rich water abolishes an immediate-type allergic reaction in mice...
  42. doi Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice
    Naomi Nakashima-Kamimura
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Cancer Chemother Pharmacol 64:753-61. 2009
    ..We have reported that molecular hydrogen (H(2)) acts as an efficient antioxidant (Ohsawa et al. in Nat Med 13:688-694, 2007)...
  43. ncbi Molecular hydrogen as an energy source for Helicobacter pylori
    Jonathan W Olson
    Department of Microbiology, University of Georgia, Athens, GA 30602, USA
    Science 298:1788-90. 2002
    The gastric pathogen Helicobacter pylori is known to be able to use molecular hydrogen as a respiratory substrate when grown in the laboratory...
  44. ncbi Hydrogenases and hydrogen photoproduction in oxygenic photosynthetic organisms
    Maria L Ghirardi
    National Renewable Energy Laboratory, Golden, CO 80401, USA
    Annu Rev Plant Biol 58:71-91. 2007
    ..Some of this effort is clearly driven by the potential for using these enzymes in future biological or biohybrid systems to produce renewable fuel or in fuel cell applications...
  45. pmc Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions
    Michael J Chalmers
    The Scripps Research Molecular Screening Center, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA
    Expert Rev Proteomics 8:43-59. 2011
    ..Differential hydrogen/deuterium exchange (HDX) coupled with mass spectrometry has emerged as a rapid and sensitive approach for ..
  46. doi Enhanced catalytic activity in strained chemically exfoliated WS₂ nanosheets for hydrogen evolution
    Damien Voiry
    Rutgers University, Materials Science and Engineering, 607 Taylor Road, Piscataway, New Jersey 08854, USA
    Nat Mater 12:850-5. 2013
    Efficient evolution of hydrogen through electrocatalysis at low overpotentials holds tremendous promise for clean energy...
  47. doi Defect-rich MoS2 ultrathin nanosheets with additional active edge sites for enhanced electrocatalytic hydrogen evolution
    Junfeng Xie
    Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, P R China
    Adv Mater 25:5807-13. 2013
    Defect-rich MoS2 ultrathin nanosheets are synthesized on a gram scale for electrocatalytic hydrogen evolution...
  48. doi Towards mild metal-catalyzed C-H bond activation
    Joanna Wencel-Delord
    Westfalische Wilhelms Universitat Munster, Organisch Chemisches Institut, Corrensstrasse 40, 48149 Munster, Germany
    Chem Soc Rev 40:4740-61. 2011
    Functionalizing traditionally inert carbon-hydrogen bonds represents a powerful transformation in organic synthesis, providing new entries to valuable structural motifs and improving the overall synthetic efficiency...
  49. doi Hydrogen-treated TiO2 nanowire arrays for photoelectrochemical water splitting
    Gongming Wang
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064 United States
    Nano Lett 11:3026-33. 2011
    We report the first demonstration of hydrogen treatment as a simple and effective strategy to fundamentally improve the performance of TiO(2) nanowires for photoelectrochemical (PEC) water splitting...
  50. doi Hydrogen, metals, bifurcating electrons, and proton gradients: the early evolution of biological energy conservation
    William F Martin
    Institute of Molecular Evolution, University of Dusseldorf, 40225 Dusseldorf, Germany
    FEBS Lett 586:485-93. 2012
    ..Electron bifurcation likely figures into the early evolution of biological energy conservation...
  51. doi Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice
    Naomi Kamimura
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Obesity (Silver Spring) 19:1396-403. 2011
    Recent extensive studies have revealed that molecular hydrogen (H(2)) has great potential for improving oxidative stress-related diseases by inhaling H(2) gas, injecting saline with dissolved H(2), or drinking water with dissolved H(2) (H(..
  52. ncbi Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma
    M Xiao
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China
    Eur Rev Med Pharmacol Sci 17:1033-43. 2013
    Recent studies suggest that hydrogen has great therapeutic and prophylactic potential against organ injury caused by oxidative stress and inflammation...
  53. doi Selective drug trace detection with low-field NMR
    Stefan Glöggler
    Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany
    Analyst 136:1566-8. 2011
    Advances with para-hydrogen induced polarization open up new fields of applications for portable low-field NMR. Here we report the possibility of tracing drugs down to the micromolar regime...
  54. doi Highly efficient electrocatalytic hydrogen production by MoS(x) grown on graphene-protected 3D Ni foams
    Yung Huang Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan, ROC
    Adv Mater 25:756-60. 2013
    ..graphene layers on surfaces is used as a conducting solid support to load MoS(x) catalysts for electrocatalytic hydrogen evolution...
  55. pmc The iron-hydrogenase of Thermotoga maritima utilizes ferredoxin and NADH synergistically: a new perspective on anaerobic hydrogen production
    Gerrit J Schut
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602 7229, USA
    J Bacteriol 191:4451-7. 2009
    ..The discovery of the bifurcating hydrogenase gives a new perspective on our understanding of the bioenergetics and mechanism of H(2) production and of anaerobic metabolism in general...
  56. doi Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice
    Daisuke Kawai
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Okayama, Japan
    Hepatology 56:912-21. 2012
    ..Molecular hydrogen is an effective antioxidant that reduces cytotoxic reactive oxygen species...
  57. pmc Evidence for hydrogen oxidation and metabolic plasticity in widespread deep-sea sulfur-oxidizing bacteria
    Karthik Anantharaman
    Department of Earth and Environmental Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 110:330-5. 2013
    ..This study also highlights the genomic plasticity of SUP05, which enables this widely distributed group to optimize its energy metabolism (electron donor and acceptor) to local geochemical conditions...
  58. doi Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs
    Ferenc Domoki
    Department of Physiology, University of Szeged School of Medicine, Szeged H 6720, Hungary
    Pediatr Res 68:387-92. 2010
    b>Hydrogen (H2) has been reported to neutralize toxic reactive oxygen species. Oxidative stress is an important mechanism of neuronal damage after perinatal asphyxia. We examined whether 2...
  59. doi Production of biohydrogen by heterologous expression of oxygen-tolerant Hydrogenovibrio marinus [NiFe]-hydrogenase in Escherichia coli
    Jaoon Y H Kim
    Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 790 784, Republic of Korea
    J Biotechnol 155:312-9. 2011
    Oxygen sensitivity of hydrogenase is a critical issue in efficient biological hydrogen production...
  60. doi A pyruvate formate lyase-deficient Chlamydomonas reinhardtii strain provides evidence for a link between fermentation and hydrogen production in green algae
    Gabriele Philipps
    Ruhr Universitat Bochum, Fakultät für Biologie und Biotechnologie, Lehrstuhl für Biochemie der Pflanzen, AG Photobiotechnologie, 44780 Bochum, Germany
    Plant J 66:330-40. 2011
    ..To identify mutant strains with altered hydrogen metabolism, a C. reinhardtii nuclear transformant library was screened...
  61. doi Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals
    Yunhai Chuai
    Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, People s Republic of China
    Biochem J 442:49-56. 2012
    Our recent studies suggest that H2 (hydrogen) has a potential as a novel radioprotector without known toxic side effects...
  62. pmc Identification of the [FeFe]-hydrogenase responsible for hydrogen generation in Thermoanaerobacterium saccharolyticum and demonstration of increased ethanol yield via hydrogenase knockout
    A Joe Shaw
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755, USA
    J Bacteriol 191:6457-64. 2009
    ..genes, provisionally termed hfs (hydrogenase-Fe-S), was found to be the main enzymatic catalyst of hydrogen production...
  63. pmc Redirection of metabolism for biological hydrogen production
    Federico E Rey
    Department of Microbiology, Box 357242, 1959 N E Pacific Street, University of Washington, Seattle, WA 98195 7242, USA
    Appl Environ Microbiol 73:1665-71. 2007
    A major route for hydrogen production by purple photosynthetic bacteria is biological nitrogen fixation. Nitrogenases reduce atmospheric nitrogen to ammonia with the concomitant obligate production of molecular hydrogen...
  64. doi Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release
    Keliang Xie
    Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin, P R China
    Shock 34:90-7. 2010
    ..Recently, it has been suggested that molecular hydrogen (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radicals (*OH, the most cytotoxic ..
  65. doi Effect of dietary turmeric on breath hydrogen
    Akito Shimouchi
    Department of Etiology and Pathogenesis, National Cardiovascular Center Research Institute, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565, Japan
    Dig Dis Sci 54:1725-9. 2009
    ..In the present study, we hypothesized that turmeric in curry might increase bowel motility and activate hydrogen-producing bacterial flora in the colon, thereby increasing the concentration of breath hydrogen...
  66. ncbi Molecular recognition in the selective oxygenation of saturated C-H bonds by a dimanganese catalyst
    Siddhartha Das
    Department of Chemistry, Yale University, 225 Prospect Street, Post Office Box 208107, New Haven, CT 06520 8107, USA
    Science 312:1941-3. 2006
    ..We combined molecular recognition through hydrogen bonding with C-H activation to obtain high-turnover catalytic regioselective functionalization of sp3 C-H bonds ..
  67. pmc Metabolic modeling of a mutualistic microbial community
    Sergey Stolyar
    Department of Civil and Environmental Engineering, University of Washington, Seattle, WA 98195, USA
    Mol Syst Biol 3:92. 2007
    ..model and our data suggested that it was possible to eliminate formate as an interspecies electron shuttle, but hydrogen transfer was essential for syntrophic growth...
  68. ncbi Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki City 211 8533, Japan
    Nat Med 13:688-94. 2007
    ..We show here that hydrogen (H(2)) has potential as an antioxidant in preventive and therapeutic applications...
  69. ncbi A membrane-bound multienzyme, hydrogen-oxidizing, and sulfur-reducing complex from the hyperthermophilic bacterium Aquifex aeolicus
    Marianne Guiral
    Laboratoire de Bioenergetique et Ingenierie des Proteines, IBSM CNRS, 13402 Marseille, France
    J Biol Chem 280:42004-15. 2005
    Aquifex aeolicus is a hyperthermophilic, chemolithoautotrophic, hydrogen-oxidizing, and microaerophilic bacterium growing at 85 degrees C...
  70. ncbi Biomimetic hydrogen evolution: MoS2 nanoparticles as catalyst for hydrogen evolution
    Berit Hinnemann
    Center for Atomic scale Materials Physics, Department of Physics, NanoDTU, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Am Chem Soc 127:5308-9. 2005
    The electrochemical hydrogen evolution reaction is catalyzed most effectively by the Pt group metals...
  71. ncbi Light-driven water splitting for (bio-)hydrogen production: photosystem 2 as the central part of a bioelectrochemical device
    Adrian Badura
    Plant Biochemistry, Faculty of Biology, Ruhr University Bochum, D 44780 Bochum, Germany
    Photochem Photobiol 82:1385-90. 2006
    To establish a semiartificial device for (bio-)hydrogen production utilizing photosynthetic water oxidation, we report on the immobilization of a Photosystem 2 on electrode surfaces...
  72. doi Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both
    Atsunori Nakao
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittburgh, Pennsylvania 15213, USA
    J Heart Lung Transplant 29:544-53. 2010
    Recent advances in novel medical gases, including hydrogen and carbon monoxide (CO), have demonstrated significant opportunities for therapeutic use...
  73. doi Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice
    Yasunori Sato
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University, Chiba 274 8510, Japan
    Biochem Biophys Res Commun 375:346-50. 2008
    b>Hydrogen is an established anti-oxidant that prevents acute oxidative stress...
  74. pmc Iridium N-heterocyclic carbene complexes as efficient catalysts for magnetization transfer from para-hydrogen
    Michael J Cowley
    Department of Chemistry, University of York, Heslington, York YO10 5DD, UK
    J Am Chem Soc 133:6134-7. 2011
    ..Deuterium labeling yields an additional 60% improvement in signal, an observation that offers insight into strategies for optimizing this approach...
  75. pmc Sustained photobiological hydrogen gas production upon reversible inactivation of oxygen evolution in the green alga Chlamydomonas reinhardtii
    A Melis
    Department of Plant and Microbial Biology, University of California, 111 Koshland Hall, Berkeley, California 94720 3102, USA
    Plant Physiol 122:127-36. 2000
    ..The latter catalyzes the reduction of protons to molecular H(2) in the chloroplast stroma...
  76. doi Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages
    Tomohiro Itoh
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Biochem Biophys Res Commun 411:143-9. 2011
    Molecular hydrogen has been reported to be effective for a variety of disorders and its effects have been ascribed to the reduction of oxidative stress...
  77. doi A unique iron-sulfur cluster is crucial for oxygen tolerance of a [NiFe]-hydrogenase
    Tobias Goris
    Institut für Biologie Mikrobiologie, Humboldt Universitat zu Berlin, Berlin, Germany
    Nat Chem Biol 7:310-8. 2011
    ..The data indicate that the mechanism of O(2) tolerance relies on the reductive removal of oxygenic species guided by the unique architecture of the electron relay rather than a restricted access of O(2) to the active site...
  78. pmc Hydrogen and bioenergetics in the Yellowstone geothermal ecosystem
    John R Spear
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 102:2555-60. 2005
    ..comprised of organisms of the kinds that derive energy for primary productivity from the oxidation of molecular hydrogen, H2...
  79. doi Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats
    Tomohiro Kawamura
    Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 90:1344-51. 2010
    ..b>Hydrogen gas has potent antioxidant and antiapoptotic properties and has been recently used in number of experimental and ..
  80. doi Electron transfer in syntrophic communities of anaerobic bacteria and archaea
    Alfons J M Stams
    Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
    Nat Rev Microbiol 7:568-77. 2009
    ..Here, we review the transfer of hydrogen and formate between bacteria and archaea that helps to sustain growth in syntrophic methanogenic communities...
  81. pmc Nitrogen fixation and hydrogen metabolism in cyanobacteria
    Hermann Bothe
    Botanical Institute, The University of Cologne, Zülpicher Str 47b, D 50923 Cologne, Germany
    Microbiol Mol Biol Rev 74:529-51. 2010
    This review summarizes recent aspects of (di)nitrogen fixation and (di)hydrogen metabolism, with emphasis on cyanobacteria...
  82. pmc Coupling of ferredoxin and heterodisulfide reduction via electron bifurcation in hydrogenotrophic methanogenic archaea
    Anne Kristin Kaster
    Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany
    Proc Natl Acad Sci U S A 108:2981-6. 2011
    ..This stoichiometry of coupling is consistent with an ATP gain per mole methane from 4 H(2) and CO(2) of near 0.5 deduced from an H(2)-threshold concentration of 8 Pa and a growth yield of up to 3 g/mol methane...
  83. ncbi Improved photobiological H2 production in engineered green algal cells
    Olaf Kruse
    Department of Biology VIII, Molecular Cell Physiology, University Bielefeld, 33501 Bielefeld, Germany
    J Biol Chem 280:34170-7. 2005
    ..alga Chlamydomonas reinhardtii, has evolved the additional ability to redirect the derived H+ and e- to drive hydrogen (H2) production via the chloroplast hydrogenases HydA1 and A2 (H2 ase)...
  84. doi Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis
    Mikihito Kajiya
    Department of Immunology, The Forsyth Institute, Boston, MA, USA
    Biochem Biophys Res Commun 386:316-21. 2009
    ..well known that some intestinal bacteria, such as Escherichia coli, can produce a remarkable amount of molecular hydrogen (H(2))...
  85. ncbi Eukaryotic evolution, changes and challenges
    T Martin Embley
    School of Biology, The Devonshire Building, University of Newcastle upon Tyne, Newcastle NE1 7RU, UK
    Nature 440:623-30. 2006
    ..But the evolutionary gap between prokaryotes and eukaryotes is now deeper, and the nature of the host that acquired the mitochondrion more obscure, than ever before...
  86. doi Electrochemical kinetic investigations of the reactions of [FeFe]-hydrogenases with carbon monoxide and oxygen: comparing the importance of gas tunnels and active-site electronic/redox effects
    Gabrielle Goldet
    Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QR, United Kingdom
    J Am Chem Soc 131:14979-89. 2009
    ....
  87. pmc Auxiliary-assisted palladium-catalyzed arylation and alkylation of sp2 and sp3 carbon-hydrogen bonds
    Dmitry Shabashov
    Department of Chemistry, University of Houston, Houston, Texas 77204 5003, USA
    J Am Chem Soc 132:3965-72. 2010
    ..Preliminary mechanistic studies have been performed. A palladacycle intermediate has been isolated, characterized by X-ray crystallography, and its reactions have been studied...
  88. doi Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats
    Xingfeng Zheng
    Chinese PLA Institute of Burn Surgery and Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Free Radic Res 43:478-84. 2009
    b>Hydrogen gas was reported to reduce reactive oxygen species and alleviate cerebral, myocardial and hepatic ischemia/reperfusion (I/R) injuries...
  89. doi Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease
    Cai Wang
    Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, PR China
    Neurosci Lett 491:127-32. 2011
    This study is to examine if hydrogen-rich saline reduced amyloid-beta (Aβ) induced neural inflammation and oxidative stress in a rat model by attenuation of activation of JNK and NF-κB...
  90. doi The protective role of hydrogen-rich saline in experimental liver injury in mice
    Hanyong Sun
    International Co operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, PR China
    J Hepatol 54:471-80. 2011
    ..Antioxidants have been effectively demonstrated to protect against hepatic damage. Hydrogen (H(2)), a new antioxidant, was reported to selectively reduce the strongest oxidants, such as hydroxyl radicals (..
  91. doi Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis
    Keliang Xie
    Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin, People s Republic of China
    Shock 37:548-55. 2012
    ..Recently, our and other studies have found that hydrogen gas (H₂) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-..
  92. pmc Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits
    Zong Zhuang
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China
    BMC Neurosci 13:47. 2012
    ..The present study aimed to examine the effect of hydrogen, a mild and selective cytotoxic oxygen radical scavenger, on oxidative stress injury, brain edema and neurology ..
  93. pmc Hydrogen donor-acceptor fluctuations from kinetic isotope effects: a phenomenological model
    Daniel Roston
    Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA
    Biochemistry 51:6860-70. 2012
    ..This model assumes adiabatic hydrogen tunneling, and by fitting experimental KIE data, the model yields a population distribution for fluctuations of ..
  94. pmc Heterocycle synthesis via direct C-H/N-H coupling
    Enrico T Nadres
    Department of Chemistry, University of Houston, Houston, Texas 77204 5003, USA
    J Am Chem Soc 134:7-10. 2012
    ..The method employs a picolinamide directing group, PhI(OAc)(2) oxidant, and toluene solvent at 80-120 °C. Cyclization is effective for sp(2) as well as aliphatic and benzylic sp(3) C-H bonds...
  95. pmc Practical and innate carbon-hydrogen functionalization of heterocycles
    Yuta Fujiwara
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 492:95-9. 2012
    ..The reagents can even be used in tandem fashion in a single pot in the presence of water and air...
  96. pmc Hydrogen tunneling links protein dynamics to enzyme catalysis
    Judith P Klinman
    Department of Chemistry, California Institute for Quantitative Sciences, University of California, Berkeley, California 94720, USA
    Annu Rev Biochem 82:471-96. 2013
    ..Here, we show how the quantum mechanical hydrogen tunneling associated with enzymatic C-H bond cleavage provides a unique window into the necessity of protein ..
  97. pmc Controlling protein adsorption on graphene for cryo-EM using low-energy hydrogen plasmas
    Christopher J Russo
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Nat Methods 11:649-52. 2014
    ..We describe a method to modify graphene with a low-energy hydrogen plasma, which reduces hydrophobicity without degrading the graphene lattice...
  98. doi Conductive dense hydrogen
    M I Eremets
    Max Planck Institute for Chemistry, Biogeochemistry Department, PO Box 3060, 55020 Mainz, Germany
    Nat Mater 10:927-31. 2011
    Molecular hydrogen is expected to exhibit metallic properties under megabar pressures...
  99. ncbi Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water
    Yuji Nakai
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 75:774-6. 2011
    The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats...
  100. doi Strong N-H...pi hydrogen bonding in amide-benzene interactions
    Philipp Ottiger
    Departement für Chemie and Biochemie, Universitat Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    J Phys Chem B 113:2937-43. 2009
    ..Both MP2 and SCS-MP2 geometry optimizations yield a T-shaped structure with a N--H...pi hydrogen bond to the benzene ring and the C=O group above, but far from the C--H bonds of benzene...
  101. pmc Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats
    Yan Zhan
    Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Crit Care Med 40:1291-6. 2012
    b>Hydrogen gas has been demonstrated to neutralize free radicals and reduce oxidative stress recently...

Research Grants77

  1. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..The electrons donated by NADPH are instead diverted to O2, to form superoxide and ultimately hydrogen peroxide...
  2. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..the free radical superoxide anion that is subsequently converted into powerful toxins, including peroxynitrite, hydrogen peroxide, and hydroxyl radical...
  3. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..catalyst of reactive oxygen species degradation: a superoxide dismutase mimetic, a catalase mimic that detoxifies hydrogen peroxide, and a peroxynitrite decomposition catalyst...
  4. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..or indirectly by maintaining an intricate balance among cellular homocysteine (Hcy), glutathione (GSH) and hydrogen sulfide (H2S) levels...
  5. Epigenetic mechanisms relevant to the pathogenesis of ALS
    Neil W Kowall; Fiscal Year: 2013
    ..of oxidative injury in neurons, we treated NSC-34 motor neuronal cells transfected with LSD1 shRNA with hydrogen peroxide and found that reduced LSD1 expression was associated with resistance to oxidative injury further ..
  6. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..1) plays a role in GAS oxidative stress responses and virulence. Comparison of global responses to hydrogen peroxide (H2O2) or to H2O2 combined with human neutrophil granule contents in wild type versus perR mutant ..
  7. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..measure reactive oxygen species (superoxide and hydrogen peroxide) in coronary and adipose arterioles following exposure to amyloid light chain and 3...
  8. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..Upon activation these inflammatory phagocytes release MPO and begin to generate hydrogen peroxide (H2O2), which is required to activate MPO...
  9. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..VPO, when co- expressed in cells with novel vascular Noxes, utilizes hydrogen peroxide produced by these Noxes to catalyze peroxidative reactions...
  10. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    ..Importantly, hydrogen peroxide (H2O2) produced by PMN is amplified by the PMN granule protein myeloperoxidase (MPO) to generate HOCl (..
  11. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..control critical virulence properties including the structure of its lipooligosaccharide (LOS) and resistance to hydrogen peroxide...
  12. Role of Peroxidasin in Glomerular Matrix Homeostasis
    Gautam Bhave; Fiscal Year: 2013
    ..Superoxide and its product, hydrogen peroxide (H2O2), are ROS that have garnered greatest attention in DN...
  13. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..This proposal has 4 specific aims. 1. We will microfabricate an electrochemical probe of CBF based on the hydrogen clearance technique...
  14. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..Fawn Hooded Rats (FHR), and have identified problems in the FHR's mitochondria, namely lower production of hydrogen peroxide and fragmentation of the mitochondrial network, which create a pseudohypoxic environment that favors ..
  15. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..gain and loss of function studies will be performed by transient transfection and use of siRNA and the effects of hydrogen peroxide and free radical scavenging on the ERK/STAT3/RANKL cascade will be examined...
  16. Transcriptional Regulation of Natriuetic Sensitivity in Diabetes Mellitus
    PATIENCE O OBIH; Fiscal Year: 2012
    ..amiloride, or furosemide, as indices of activity of sodium chloride co-transporter (NCC), sodium hydrogen exchanger (NHE) and sodium-potassium chloride cotransporter (NKCC), respectively...
  17. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..levels of Reactive Oxygen and Nitrogen Species (ROS/RNS), such as nitric oxide, superoxide, the hydroxyl radical, hydrogen peroxide and peroxynitrite...
  18. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ..We have recently demonstrated a novel feed-forward regulation of NOX5 by hydrogen peroxide (H2O2) acting through a signaling pathway involving calcium and the non-receptor tyrosine kinase c-Abl...
  19. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ..We also will examine the inductive role of the oxyanion hole, the nucleophile rendering catalytic triad and the hydrogen bonding network between the proximal serine hydroxyls at the base of the gorge...
  20. Novel pathways for fat burning that protects from high fat diet-induced metabolic
    Sihem Boudina; Fiscal Year: 2013
    ..deletion of manganese superoxide dismutase (MnSOD), the sole enzyme responsible for detoxifying superoxide to hydrogen peroxide in the mitochondrial matrix...
  21. Electron Transfer in Iron and Copper Proteins
    Jay R Winkler; Fiscal Year: 2013
    ..Mutant proteins in which proton accepting residues are within hydrogen-bonding distance of the intermediate tyrosine residue also will be prepared...
  22. Mitochondrial Mechanisms of Programmed Necrosis in the Aged Female Heart
    Alexandra M Machikas; Fiscal Year: 2013
    ..respiration rate, calcium retention capacity (CRC), and fluorescent detection of superoxide, peroxynitrite, and hydrogen peroxide...
  23. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
    ..highly sensitive to genotoxic agents including DNA alkylating agents and reactive oxygen species (ROS) such as hydrogen peroxide...
  24. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN JD O'KEEFE; Fiscal Year: 2012
    ..which increases microbiota populations of sulfur-reducing bacteria (SRBs), which produce cytotoxic and genotoxic hydrogen sulfide as a terminal product...
  25. Development of Novel LANCL2-based Anti-diabetic Compounds
    JOSEP BASSAGANYA; Fiscal Year: 2013
    ..properties (ClogP, molecular weight, polar surface area, numbers of rings, rotable bonds, N and O atoms, hydrogen bond donors and acceptors) within the guidelines;and test their efficacy and safety...
  26. Host Defense Mechanisms in Polyaromatic Hydrogen Carcinogenesis
    Craig A Elmets; Fiscal Year: 2013
    ..We have developed novel reagents and we utilize them as a vaccine to determine if they augment immunity to PAHs and can be used to prevent tumors from developing in the first place. ..
  27. TRP channels in regulation of vascular tone
    David X Zhang; Fiscal Year: 2013
    ..oxide (NO) in subjects without coronary artery disease (CAD), and reactive oxygen species (ROS), specifically hydrogen peroxide (H2O2) derived from the mitochondrial electron transport chain, in CAD patients...
  28. Biosynthetic Protein Models of Heme-copper Oxidases and Nitric Oxide Reductases
    Yi Lu; Fiscal Year: 2013
    ..that is covalently linked to a CuB-His ligand, and non-covalent interactions, such as water and the associated hydrogen bonding network;2) elucidate structural features responsible for NOR function, specifically the FeB site and ..
  29. Novel therapeutics for vesicants and toxic inhaled chemicals (U54)
    Carl W White; Fiscal Year: 2013
    ..Catalytic antioxidant AEOL10150, which scavenges superoxide, hydrogen peroxide, lipid peroxides, and peroxynitrite, rescued: a) upper (nasal) and lower airway injuries by CEES;b) ..
  30. Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer Progression
    Hirak S Basu; Fiscal Year: 2012
    ..of natural cancer causative agents, cellular reactive oxygen species (ROS) such as superoxide, hydroxyl radical, hydrogen peroxide, etc...
  31. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..Factors that stimulate primary sensory neurons include hydrogen ions, heat, leukotrienes, arachidonic acid metabolites, bradykinin, and proteases such as trypsin, all of which ..
  32. Mitochondrial Metabolism and ROS Regulate Lung Cancer
    Navdeep S Chandel; Fiscal Year: 2013
    ..The major form of ROS that participates in signaling in the cytosol is hydrogen peroxide (H2O2), which is generated by its conversion from superoxide (O2-) by copper-zinc superoxide dismutase (..
  33. DNA Repair of Endogenous Lesions in Carcinogenesis
    Rabindra Roy; Fiscal Year: 2010
    ..DNA glycosylase(s) and/or other rate-limiting BER enzymes by assessing the effects of metals (copper and iron), hydrogen peroxide, and enals in hepatocytes of LEA and LEG rats and comparing the effects with that observed in tissues ..
  34. Apple peel extract inhibits Cr(VI)-induced lung cancer
    Zhuo Zhang; Fiscal Year: 2013
    ..radical and chelation of Cr(V) by apple peel extract to make this chromium intermediate less reactive toward hydrogen peroxide(H2O2) for [unreadable]OH radical generation...
  35. Redox regulation of intestinal T cells
    ALAN DAVID LEVINE; Fiscal Year: 2010
    ..this proposal we will focus on reactive oxygen species (ROS) derived from incomplete reduction of oxygen, such as hydrogen peroxide, acting as second messengers and thus endogenous modulators of signal transduction emanating from the ..
  36. Novel Catalases and their Products
    Alan R Brash; Fiscal Year: 2013
    ..Catalase is renowned for its efficient reaction with hydrogen peroxide and its key role in the oxidative defense of all aerobic organisms...
  37. The Role of Syntrophic Bacteria in Methanogenic Metabolism in the Human Gut
    Catherine Lozupone; Fiscal Year: 2013
    ..increase the efficiency of bacterial fermentation by preventing the accumulation of metabolic products such as hydrogen 2) they are thought to be a "keystone" species, (i.e...
  38. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    b>Hydrogen sulfide (H2S) has recently been identified as a physiologically important endogenous gaseous signaling molecule with a diverse array of biological activities...
  39. Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ..based on recent studies indicating that acrolein is detoxified by glutathione S-transferase P1 (GSTP1) and by hydrogen sulfide (H2S), a newly recognized endogenous mediator produced by (homo)cysteine metabolism by cystathionine [..
  40. PLCgamma regulates HNE3 activity through direct binding and dynamic complexes
    NICHOLAS CONSTANTINE ZACHOS; Fiscal Year: 2011
    ..The sodium/hydrogen exchanger (NHE) gene family plays an integral role in sodium absorption in the mammalian intestine...
  41. NHERF-1 and dopamine-mediated regulation of renal phosphate transport.
    Edward J Weinman; Fiscal Year: 2013
    ..to the apical membrane by a PDZ domain adaptor protein isolated and cloned by our laboratory called the Sodium-Hydrogen Exchanger Regulatory Factor-1 (NHERF-1)...
  42. Molecular Imaging Probes for Reporting on Vascular Oxidative Response
    Alexei A Bogdanov; Fiscal Year: 2013
    ..MPO activity in vascular lesions is rate-limited by the rates of local hydrogen peroxide production...
  43. Angiotensin-induced Oxidants and Vascular Cell Phenotype
    Richard Cohen; Fiscal Year: 2009
    ..In addition, in the smooth muscle, hydrogen peroxide (H2O2) formed by dismutation of NADPH oxidase-derived superoxide (O2) is an important ROS that mediates ..
  44. NADPH-Oxidase and SLE Susceptibility
    Swapan K Nath; Fiscal Year: 2013
    ..Reactive oxygen species (ROS), such as superoxide and hydrogen peroxide are key for defense against invading microbial pathogens, and are produced by the multi-protein NADPH- ..
  45. Analysis of PTH and Dopamine Receptor Signaling in Proximal Tubules
    Eleanor D Lederer; Fiscal Year: 2013
    ..Project Summary/Abstract The goal of this project is to determine how the structural protein NHERF-1, sodium-hydrogen exchanger regulatory factor isoform 1, regulates the trafficking of Npt2a, the type IIa sodium phosphate ..
  46. Computational Design of Small Molecule Drugs Inhibiting the Zinc Finger Transcrip
    David Sherris; Fiscal Year: 2010
    ..of the VEZF1/DNA complex, 2) cavities with at least some hydrophobic regions, and 3) polar atoms available for hydrogen bonding with ligand atoms...
  47. Plasmalogen-derived bioactive lipids in atherosclerosis
    David A Ford; Fiscal Year: 2013
    ..Upon activation, monocytes and macrophages release MPO and produce its substrate, hydrogen peroxide, resulting in MPO-catalyzed production of the reactive chlorinating species (RCS), hypochlorous acid...
  48. Ca2+ mishandling and ischemia-vulnerability in fALS model motor terminals
    Gavriel David; Fiscal Year: 2012
    ..frequency stimulation of motor nerves, energy stresses (ischemia/reperfusion, oxygen/glucose deprivation) and hydrogen peroxide...
  49. Role of Polyamine Oxidase in Apoptosis Studies with RNA Interference
    GLENN KUEHN; Fiscal Year: 2009
    ..Polyamine oxidase (PAO) catalyzes oxygen-dependent cleavage of the polyamines to form hydrogen peroxide (H2O2), among other products...
  50. RNA Modification Enzymes: Methyltransferase/psi-synthase
    Robert M Stroud; Fiscal Year: 2012
    ..thereby altering the stability, higher-order structure, and activity of RNA through changes in base stacking and hydrogen bonding...
  51. ASCORBATE-INDUCED RADIOSENSITIZATION IN PANCREATIC CANCER
    Joseph J Cullen; Fiscal Year: 2013
    ..normal cells. We have firmly established that pharmacological ascorbate is a pro-drug for delivery of hydrogen peroxide (H2O2) in vitro and in vivo via its autoxidation...
  52. Chemistry, Structure and Biology of Thiol Transferases
    Richard N Armstrong; Fiscal Year: 2013
    ..All of these proteins are integral membrane proteins. Specific Aim 1 relies heavily on hydrogen/deuterium exchange mass spectrometry (H/DEX MS) to probe the structural aspects of these proteins as they ..
  53. Re-Wiring Cellular Metabolism to Control Biofilm Formation and Virulence BY...
    Thomas K Wood; Fiscal Year: 2011
    ..S. or 3% GNP), forming hydrogen for fuel cells, rhizoremediation and biocontrol in agriculture, and patterning in microfluidic devices...
  54. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2010
    ..the apoptotic signaling pathways activated by androgens in dopaminergic N27 cells following oxidative stress (hydrogen peroxide)...
  55. Role of homocysteine in retinal disease
    Sylvia B Smith; Fiscal Year: 2013
    ..the "transsulfuration pathway" leading to formation of cysteine, which is then converted to glutathione (GSH), hydrogen sulfide (H2S), and/or taurine, the observed disrupted retinal structure/function may be due to decreased levels ..
  56. Hydrogen Peroxide and Flow-Induced Dilation of Human Coronary Microcirculation
    David D Gutterman; Fiscal Year: 2012
    ..operates through a novel mechanism involving endothelial production of reactive oxygen species (ROS) including hydrogen peroxide (H2O2)...
  57. Identification, Discovery, and Public Archiving of RNA Structural Motifs
    Shaojie Zhang; Fiscal Year: 2013
    ..develop a new computational search tool which will, in addition to 3D geometry, take into account base pairing (hydrogen bonding forces) and base stack- ing (magnetic and electrostatic forces) information...
  58. Targeting of alpha7 nAChR for therapeutic effects
    Roger L Papke; Fiscal Year: 2013
    ..We will investigate the potential importance of hydrogen bonding and hydrophobic interactions on the binding, gating, and desensitizing properties of the specific ..
  59. Studies toward the development of monoamine oxidase B specific inhibitors
    ERIKA MARIE MILCZEK; Fiscal Year: 2010
    ..known that the age-related increase in MAO B levels in neuronal tissue together with the catalytic production of hydrogen peroxide (leading to reactive oxygen species) contributes to cellular apoptosis and subsequent neurodegeneration...
  60. Catalase therapy for cardiac regeneration
    Michael E Davis; Fiscal Year: 2013
    ..superoxide following infarction not only increases damage to the local myocardium, but through dismutation to hydrogen peroxide may increase lipid peroxidation and cardiac fibrosis...
  61. pH Regulation in Bacillus subtilis (AREA R15)
    JOAN SLONCZEWSKI; Fiscal Year: 2009
    ..pH regulation of hydrogenase enzymes has implications for the biological production of hydrogen fuel...
  62. Angiogenesis and Long-term Bone and Joint Allotransplant Survival
    Allen T Bishop; Fiscal Year: 2012
    ..is measured at two time points by quantifying capillary density with microangiography and bone blood flow by hydrogen washout;while bone remodeling is determined after fluorochrome labeling by quantitative histomorphometry...
  63. Control of AMPA receptor function by phosphorylation
    Stephen F Traynelis; Fiscal Year: 2013
    ..regulation of AMPA receptor function? We will identify intracellular GluR1 residues as phospho-Ser831 hydrogen bonding partners...
  64. REACTION MECHANISM OF MYOCARDIAC UBIQUINONE-PROTEINS
    Chang An Yu; Fiscal Year: 2009
    ..mechanistic studies, including the Q-binding at the Qo site pocket, the proton transfer path, structure water, hydrogen bonding, and the interaction domain between cytochromes c\ and c...
  65. Bacterial Response to Singlet Oxygen
    Timothy Donohue; Fiscal Year: 2009
    ..When single electrons are transferred to O2, it is reduced to superoxide, hydrogen peroxide, or hydroxyl radicals. When energy is transferred to O2, singlet oxygen ([1]O2) is formed...
  66. OXIDANT MECHANISMS IN MEMBRANOUS NEPHROPATHY
    Sudhir Shah; Fiscal Year: 1993
    ..Specific Aim: A. To examine intracellular generation of hydrogen peroxide by normal glomeruli and by glomeruli in response to anti-Fx1A antibody...
  67. GENETIC RESPONSE TO OXIDATIVE STREET IN E COLI
    SPENCER FARR; Fiscal Year: 1993
    ..application) Normal aerobic metabolism produces reactive oxygen species including superoxide anions, hydrogen peroxide and hydroxyl radicals...
  68. Mitochondrial SOD & Breast Cancer Risk-Mechanism
    JAMES YAGER; Fiscal Year: 2003
    ..to: 1) Determine the relationship between mitochondrial MnSOD protein levels, MnSOD activity, and superoxide and hydrogen peroxide production...
  69. BIOLOGICAL METAL CLUSTERS--BIOPHYSICAL & MODEL STUDIES
    Michael Maroney; Fiscal Year: 1991
    ..These enzymes serve to oxidize molecular hydrogen (or reduce hydrogen ions) and to oxidize carbon monoxide to carbon dioxide and thus serve key roles in the ..
  70. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010
    ..On the systemic level, cells that function as hydrogen ion sensors in the brain, the heart, the gut,and the tongue evoke reflexive responses that serve to mitigate and ..
  71. MODELS FOR EXPLORING FREE RADICAL DAMAGE
    Julie Andersen; Fiscal Year: 1999
    Superoxide and hydrogen peroxide are produced during normal metabolism...
  72. Development of Chemical Receptors for Proteins
    Sanku Mallik; Fiscal Year: 2005
    ..The specific goals are summarized below. Synthesis of new polymerizable zwitter-ionic, cationic and hydrogen bond forming lipids; synthesis of new polymerizable lipids capable of complexing either a transition metal ion (e...
  73. HYDROGEN PEROXIDE IN AQUEOUS HUMOR
    SIXTO GARCIA CASTINEIRAS; Fiscal Year: 1990
    b>Hydrogen peroxide has been found in the aqueous humor of several animal species including man, at the low uM level (5 to 90 uM)...
  74. A Transcutaneous Gas Sensor for Noninvasive Diagnosis of Necrotizing Enterocoliti
    OOMMAN VARGHESE; Fiscal Year: 2009
    ..In Phase I, we successfully demonstrated the application of a titania nanotube-based hydrogen sensor to monitor transcutaneous hydrogen levels for predicting lactose intolerance in volunteer patients...
  75. FREE RADICALS, PROTEIN AGGREGATES & PARKINSON'S DISEASE
    GARY PIELAK; Fiscal Year: 2001
    ..The proposed in vitro studies focus on the reactive oxygen species, hydrogen peroxide, and two proteins found in Lewy bodies, cytochrome C and alpha-synuclein...
  76. REACTIVE OXYGEN SPECIES AND VASCULAR O2 SENSING
    Michael S Wolin; Fiscal Year: 2010
    This proposal focuses on defining the role of Nox oxidase-derived hydrogen peroxide, and cytosolic NADPH and NADH redox systems in processes that control signaling mechanisms regulating vascular smooth muscle force responses to ..
  77. HIGH PERFORMANCE NEUTRON DETECTOR FOR PROTEIN CRYSTALLOGRAPHY
    JAROSLAW GLODO; Fiscal Year: 2007
    ..can easily penetrate many heavy elements, but are readily absorbed or scattered by various light isotopes, like hydrogen, deuterium, or lithium...