ozone

Summary

Summary: An unstable triatomic form of oxygen, O3, that exists in the atmosphere in varying proportions. It is produced continuously in the outer layers of the atmosphere by the action of solar UV-radiation on the oxygen of the air.

Top Publications

  1. ncbi Evidence for ozone formation in human atherosclerotic arteries
    Paul Wentworth
    Department of Chemistry, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 302:1053-6. 2003
  2. pmc Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure
    Barbara Hoffmann
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:241-6. 2012
  3. ncbi Air pollution and health
    Bert Brunekreef
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD, Utrecht, Netherlands
    Lancet 360:1233-42. 2002
  4. pmc Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
  5. ncbi Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Air Pollution and Health: a European Approach
    R W Atkinson
    Department of Public Health Sciences, St George s Hospital Medical School, London, United Kingdom
    Am J Respir Crit Care Med 164:1860-6. 2001
  6. pmc Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution
    Marcello Iriti
    Universita degli Studi di Milano, Dipartimento di Produzione Vegetale, Milano, Italy
    Int J Mol Sci 10:3371-99. 2009
  7. pmc Ozone and cardiovascular injury
    Vera Srebot
    CNR, Institute of Clinical Physiology, Pisa, Italy
    Cardiovasc Ultrasound 7:30. 2009
  8. pmc Different signaling and cell death roles of heterotrimeric G protein alpha and beta subunits in the Arabidopsis oxidative stress response to ozone
    Junghee H Joo
    Huck Institutes of the Life Sciences and Biology Department, Pen State University, University Park, Pensylvania 16802, USA
    Plant Cell 17:957-70. 2005
  9. ncbi Nitric oxide modulates ozone-induced cell death, hormone biosynthesis and gene expression in Arabidopsis thaliana
    Reetta Ahlfors
    Plant Biology, Department of Biological and Environmental Sciences, University of Helsinki, PO Box 65 Viikinkaari 1, FI 00014 Helsinki, Finland Institute of Technology, University of Tartu, Nooruse 1, Tartu 50411, Estonia
    Plant J 58:1-12. 2009
  10. pmc Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China
    Haidong Kan
    Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China
    Environ Int 33:376-84. 2007

Detail Information

Publications368 found, 100 shown here

  1. ncbi Evidence for ozone formation in human atherosclerotic arteries
    Paul Wentworth
    Department of Chemistry, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 302:1053-6. 2003
    Here, we report evidence for the production of ozone in human disease...
  2. pmc Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure
    Barbara Hoffmann
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:241-6. 2012
    ..Diabetes increases the risk of hypertension and orthostatic hypotension and raises the risk of cardiovascular death during heat waves and high pollution episodes...
  3. ncbi Air pollution and health
    Bert Brunekreef
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD, Utrecht, Netherlands
    Lancet 360:1233-42. 2002
    ..Exposure to pollutants such as airborne particulate matter and ozone has been associated with increases in mortality and hospital admissions due to respiratory and cardiovascular ..
  4. pmc Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
    Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism and air pollutant responsible...
  5. ncbi Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Air Pollution and Health: a European Approach
    R W Atkinson
    Department of Public Health Sciences, St George s Hospital Medical School, London, United Kingdom
    Am J Respir Crit Care Med 164:1860-6. 2001
    ..In the 65+ groups PM(10) estimates were positively associated with annual mean concentrations of ozone in the cities...
  6. pmc Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution
    Marcello Iriti
    Universita degli Studi di Milano, Dipartimento di Produzione Vegetale, Milano, Italy
    Int J Mol Sci 10:3371-99. 2009
    ..Chronic exposure to tropospheric ozone (O(3)) stimulates the carbon fluxes from the primary to the secondary metabolic pathways to a great extent, ..
  7. pmc Ozone and cardiovascular injury
    Vera Srebot
    CNR, Institute of Clinical Physiology, Pisa, Italy
    Cardiovasc Ultrasound 7:30. 2009
    ..In the present review we will explore the epidemiological, clinical and experimental evidence of the effects of ozone on cardiovascular diseases...
  8. pmc Different signaling and cell death roles of heterotrimeric G protein alpha and beta subunits in the Arabidopsis oxidative stress response to ozone
    Junghee H Joo
    Huck Institutes of the Life Sciences and Biology Department, Pen State University, University Park, Pensylvania 16802, USA
    Plant Cell 17:957-70. 2005
    ....
  9. ncbi Nitric oxide modulates ozone-induced cell death, hormone biosynthesis and gene expression in Arabidopsis thaliana
    Reetta Ahlfors
    Plant Biology, Department of Biological and Environmental Sciences, University of Helsinki, PO Box 65 Viikinkaari 1, FI 00014 Helsinki, Finland Institute of Technology, University of Tartu, Nooruse 1, Tartu 50411, Estonia
    Plant J 58:1-12. 2009
    ..We have used ozone (O₃) as a tool to elicit ROS-activated stress responses, and to activate cell death in plant leaves...
  10. pmc Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China
    Haidong Kan
    Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China
    Environ Int 33:376-84. 2007
    ..Our analyses provide the first statistically significant evidence in China that PM2.5 has an adverse effect on population health and strengthen the rationale for further limiting levels of PM2.5 in outdoor air in Shanghai...
  11. pmc Estimated acute effects of ambient ozone and nitrogen dioxide on mortality in the Pearl River Delta of southern China
    Yebin Tao
    SKJ Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, and Centre for Environment and Health, Peking University, Beijing, China
    Environ Health Perspect 120:393-8. 2012
    ..health effects to air pollution; however, controversy remains regarding the relationship between ambient oxidants [ozone (O₃) and nitrogen dioxide (NO₂)] and mortality, especially in Asia...
  12. pmc Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring
    Richard L Auten
    Departments of Pediatrics, Duke University, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 46:454-60. 2012
    ..To determine if exposure to diesel exhaust (DE) during pregnancy worsened postnatal ozone-induced AHR, timed pregnant C57BL/6 mice were exposed to DE (0.5 or 2...
  13. pmc Long-term ozone exposure and mortality
    Michael Jerrett
    Division of Environmental Health Sciences, School of Public Health, University of California, 710 University Hall, Berkeley, CA 94720, USA
    N Engl J Med 360:1085-95. 2009
    Although many studies have linked elevations in tropospheric ozone to adverse health outcomes, the effect of long-term exposure to ozone on air pollution-related mortality remains uncertain...
  14. pmc Ozone and short-term mortality in 95 US urban communities, 1987-2000
    Michelle L Bell
    School of Forestry and Environmental Studies, Yale University, New Haven, Conn 06511, USA
    JAMA 292:2372-8. 2004
    b>Ozone has been associated with various adverse health effects, including increased rates of hospital admissions and exacerbation of respiratory illnesses...
  15. pmc Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children
    T Islam
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Los Angeles, Los Angeles, CA 90033, USA
    Thorax 64:197-202. 2009
    Because asthma has been associated with exercise and ozone exposure, an association likely mediated by oxidative stress, we hypothesised that glutathione-S-transferase (GST)P1, GSTM1, exercise and ozone exposure have interrelated effects ..
  16. pmc Ultraviolet-B- and ozone-induced biochemical changes in antioxidant enzymes of Arabidopsis thaliana
    M V Rao
    Department of Horticultural Science, University of Guelph, Ontario, Canada
    Plant Physiol 110:125-36. 1996
    Earlier studies with Arabidopsis thaliana exposed to ultraviolet B (UV-B) and ozone (O3) have indicated the differential responses of superoxide dismutase and glutathione reductase. In this study, we have investigated whether A...
  17. ncbi The search for signs of recovery of the ozone layer
    Elizabeth C Weatherhead
    Cooperative Institute for Research in Environmental Science, Campus Box 216, University of Colorado, Boulder, Colorado 80307, USA
    Nature 441:39-45. 2006
    Evidence of mid-latitude ozone depletion and proof that the Antarctic ozone hole was caused by humans spurred policy makers from the late 1980s onwards to ratify the Montreal Protocol and subsequent treaties, legislating for reduced ..
  18. ncbi Effects of personal exposure to particulate matter and ozone on arterial stiffness and heart rate variability in healthy adults
    Chang Fu Wu
    Department of Public Health, National Taiwan University, Taipei, Taiwan
    Am J Epidemiol 171:1299-309. 2010
    The effects on heart rate variability (HRV) and arterial stiffness from exposure to ambient particulate matter and ozone have not been studied simultaneously...
  19. ncbi From climate change to molecular response: redox proteomics of ozone-induced responses in soybean
    Ashley Galant
    Department of Biology, Washington University, One Brookings Drive, Campus Box 1137, St Louis, MO 63130, USA
    New Phytol 194:220-9. 2012
    b>Ozone (O₃) causes significant agricultural losses, with soybean (Glycine max) being highly sensitive to this oxidant. Here we assess the effect of elevated seasonal O₃ exposure on the total and redox proteomes of soybean...
  20. pmc Air pollution and hospital admissions for respiratory and cardiovascular diseases in Hong Kong
    T W Wong
    Department of Community and Family Medicine, Chinese University of Hong Kong
    Occup Environ Med 56:679-83. 1999
    ..To investigate short term effects of concentrations of pollutants in ambient air on hospital admissions for cardiovascular and respiratory diseases in Hong Kong...
  21. pmc The relation between temperature, ozone, and mortality in nine French cities during the heat wave of 2003
    Laurent Filleul
    Institut de Veille Sanitaire, Bordeaux, France
    Environ Health Perspect 114:1344-7. 2006
    ..During this period, elevated ozone concentrations were measured all over the country...
  22. pmc SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans
    Aili L Lazaar
    COPD Clinical Discovery, GlaxoSmithKline, King of Prussia, PA, USA
    Br J Clin Pharmacol 72:282-93. 2011
    ..A CXCR1/2 receptor antagonist has shown activity in an ozone challenge model in humans.
  23. ncbi Treatment of green table olive solutions with ozone. Effect on their polyphenol content and on Lactobacillus pentosus and Saccharomyces cerevisiae growth
    K A Segovia Bravo
    Food Biotechnology Department, Instituto de la Grasa CSIC, Avda Padre Garcia Tejero, 4 41012, Seville, Spain
    Int J Food Microbiol 114:60-8. 2007
    ..In this study we evaluated the effect of ozone treated GTOS on the growth of Saccharomyces cerevisiae and Lactobacillus pentosus...
  24. ncbi Indirect radiative forcing of climate change through ozone effects on the land-carbon sink
    S Sitch
    Met Office, Hadley Centre for Climate Prediction and Research JCHMR, Maclean Building, Wallingford, OX10 8BB, UK
    Nature 448:791-4. 2007
    ..associated with fossil fuel and biomass burning have acted to approximately double the global mean tropospheric ozone concentration, and further increases are expected over the twenty-first century...
  25. ncbi Ozone-triggered rapid stomatal response involves the production of reactive oxygen species, and is controlled by SLAC1 and OST1
    Triin Vahisalu
    Division of Plant Biology, Department of Biosciences, University of Helsinki, PO Box 65 Viikinkaari 1, FI 00014 Helsinki, Finland
    Plant J 62:442-53. 2010
    The air pollutant ozone can be used as a tool to unravel in planta processes induced by reactive oxygen species (ROS). Here, we have utilized ozone to study ROS-dependent stomatal signaling...
  26. ncbi The effect of heat- or ultra violet ozone-treatment of titanium on complement deposition from human blood plasma
    Paula Linderbäck
    Division of Applied Physics, Department of Physics and Measurement Technology, Linkoping University, SE 581 83 Linkoping, Sweden
    Biomaterials 31:4795-801. 2010
    ....
  27. ncbi Simultaneously mitigating near-term climate change and improving human health and food security
    Drew Shindell
    NASA Goddard Institute for Space Studies and Columbia Earth Institute, Columbia University, New York, NY 10025, USA
    Science 335:183-9. 2012
    Tropospheric ozone and black carbon (BC) contribute to both degraded air quality and global warming. We considered ~400 emission control measures to reduce these pollutants by using current technology and experience...
  28. pmc International Collaboration on Air Pollution and Pregnancy Outcomes (ICAPPO)
    Tracey J Woodruff
    Program on Reproductive Health and Environment, University of California San Francisco, Oakland, CA 94612, USA
    Int J Environ Res Public Health 7:2638-52. 2010
    ..Almost all participants have some measure of particulate matter, and most have ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide...
  29. ncbi Coordinated activation of metabolic pathways for antioxidants and defence compounds by jasmonates and their roles in stress tolerance in Arabidopsis
    Yuko Sasaki-Sekimoto
    Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Yokohama, Kanagawa, 226 8501, Japan
    Plant J 44:653-68. 2005
    ..These antioxidant metabolic pathways are known to be activated under oxidative stress conditions. Ozone (O3) exposure, a representative oxidative stress, is known to cause activation of antioxidant metabolism...
  30. ncbi Unprecedented Arctic ozone loss in 2011
    Gloria L Manney
    Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California 91109, USA
    Nature 478:469-75. 2011
    Chemical ozone destruction occurs over both polar regions in local winter-spring...
  31. pmc Transcriptional regulation of the CRK/DUF26 group of receptor-like protein kinases by ozone and plant hormones in Arabidopsis
    Michael Wrzaczek
    Plant Biology Division, Department of Biosciences, University of Helsinki, Helsinki, Finland
    BMC Plant Biol 10:95. 2010
    ..Despite the vast number of RLKs present in plants, however, only a few of them have been functionally characterized...
  32. ncbi Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice
    S R Kleeberger
    Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Nat Genet 17:475-8. 1997
    Exposures to the common air pollutant ozone (O3) cause decrements in pulmonary function and induce airway inflammation that is characterized by infiltration of polymorphonuclear neutrophils (PMNs; refs 1-4)...
  33. pmc An estimate of the global burden of anthropogenic ozone and fine particulate matter on premature human mortality using atmospheric modeling
    Susan C Anenberg
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 118:1189-95. 2010
    Ground-level concentrations of ozone (O3) and fine particulate matter [< or = 2.5 microm in aerodynamic diameter (PM2...
  34. ncbi The ozone paradox: ozone is a strong oxidant as well as a medical drug
    Velio Bocci
    Department of Physiology, University of Siena, Siena, Italy
    Med Res Rev 29:646-82. 2009
    After five decades characterized by empiricism and several pitfalls, some of the basic mechanisms of action of ozone in pulmonary toxicology and in medicine have been clarified...
  35. pmc Protective role of interleukin-10 in ozone-induced pulmonary inflammation
    Gillian S Backus
    National Institute of Environmental Health Sciences, Laboratory of Respiratory Biology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:1721-7. 2010
    The mechanisms underlying ozone (O₃)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators.
  36. pmc Pulmonary responses to subacute ozone exposure in obese vs. lean mice
    Stephanie A Shore
    Molecular and Integrative Physiological Sciences Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    J Appl Physiol (1985) 107:1445-52. 2009
    The purpose of this study was to determine whether obesity affects pulmonary responses following a 3-day ozone exposure. Obese db/db and lean wild-type mice were exposed to ozone (0.3 ppm) for 72 h...
  37. pmc Reactions of ozone with human skin lipids: sources of carbonyls, dicarbonyls, and hydroxycarbonyls in indoor air
    Armin Wisthaler
    Institut fur Ionenphysik und Angewandte Physik, Leopold Franzens Universitat Innsbruck, A 6020 Innsbruck, Austria
    Proc Natl Acad Sci U S A 107:6568-75. 2010
    ..reaction-mass spectrometry (PTR-MS) for direct air analyses of volatile products resulting from the reactions of ozone with human skin lipids...
  38. pmc Public health benefits of strategies to reduce greenhouse-gas emissions: health implications of short-lived greenhouse pollutants
    Kirk R Smith
    School of Public Health, University of alifornia, Berkeley, CA 94720 7360, USA
    Lancet 374:2091-103. 2009
    In this report we review the health effects of three short-lived greenhouse pollutants-black carbon, ozone, and sulphates...
  39. ncbi Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats
    James G Wagner
    Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA
    Toxicol Pathol 37:481-91. 2009
    ..g., asthma, allergic rhinitis) have enhanced inflammatory responses to inhaled ozone. We created a rodent model of ozone-enhanced allergic nasal responses in Brown Norway rats to test the therapeutic ..
  40. ncbi Susceptibility factors to ozone-related mortality: a population-based case-crossover analysis
    Massimo Stafoggia
    Department of Epidemiology, Rome E Health Authority, Rome, Italy
    Am J Respir Crit Care Med 182:376-84. 2010
    Acute effects of ozone on mortality have been extensively documented in clinical and epidemiological research. However, only a few studies have focused on subgroups of the population especially vulnerable to these effects.
  41. pmc Air pollution and emergency department visits for cardiac and respiratory conditions: a multi-city time-series analysis
    David M Stieb
    Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Postal locator 4903C, 269 Laurier Ave West Ottawa, Ontario, K1A 0K9, Canada
    Environ Health 8:25. 2009
    ....
  42. ncbi Ozone-induced production of nitric oxide and TNF-alpha and tissue injury are dependent on NF-kappaB p50
    Ladan Fakhrzadeh
    Department of Pharmacology and ToxicologyRutgers University, Piscataway, NJ 08854, USA
    Am J Physiol Lung Cell Mol Physiol 287:L279-85. 2004
    b>Ozone-induced lung injury is associated with increased production of reactive nitrogen intermediates and TNF-alpha, which have been implicated in the pathogenic process...
  43. pmc Outdoor air pollution, genetic susceptibility, and asthma management: opportunities for intervention to reduce the burden of asthma
    Frank D Gilliland
    University of Southern California, Keck School of Medicine, Department of Preventive Medicine, 1540 Alcazar St, CHP 236, Los Angeles, CA 90033, USA
    Pediatrics 123:S168-73. 2009
    ..and children with asthma in particular, are sensitive to the adverse effects of outdoor air pollutants, including ozone, nitrogen oxides, and respirable particulate matter...
  44. ncbi Mechanisms of ozone tolerance in rice: characterization of two QTLs affecting leaf bronzing by gene expression profiling and biochemical analyses
    Michael Frei
    Japan International Research Center for Agricultural Sciences JIRCAS, Crop Production and Environment Division, Abiotic Stress Tolerance Group, Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    J Exp Bot 61:1405-17. 2010
    High surface ozone concentration is increasingly being recognized as a factor that negatively affects crop yields in Asia. However, little progress has been made in developing ozone-tolerant genotypes of rice-Asia's major staple crop...
  45. ncbi Ozone risk for crops and pastures in present and future climates
    Jürg Fuhrer
    Agroscope Research Station ART, Reckenholzstrasse 191, CH 8046, Zurich, Switzerland
    Naturwissenschaften 96:173-94. 2009
    b>Ozone is the most important regional-scale air pollutant causing risks for vegetation and human health in many parts of the world...
  46. ncbi Evaluation of mammalian cell adhesion on surface-modified porous silicon
    Suet Peng Low
    School of Chemistry, Physics and Earth Sciences, Flinders University, Sturt Road, Bedford Park, 5042 SA, Australia
    Biomaterials 27:4538-46. 2006
    ..In this study, we modified the surface of porous silicon surface by ozone oxidation, silanisation or coating with collagen or serum...
  47. ncbi Analysis of unsaturated lipids by ozone-induced dissociation
    Simon H J Brown
    School of Chemistry, University of Wollongong, Wollongong, Australia
    Biochim Biophys Acta 1811:807-17. 2011
    ..In particular, we focus on the capabilities of a novel technology termed ozone-induced dissociation to identify the position(s) of double bonds in unsaturated lipids and discuss its possible ..
  48. ncbi The global atmospheric environment for the next generation
    F Dentener
    Joint Research Centre, Institute for Environment and Sustainability, via E Fermi 1, 1 21020, Ispra, Italy
    Environ Sci Technol 40:3586-94. 2006
    ..Ensemble simulations for the year 2000 are consistent among models and show a reasonable agreement with surface ozone, wet deposition, and NO2 satellite observations...
  49. pmc Estimated short-term effects of coarse particles on daily mortality in Stockholm, Sweden
    Kadri Meister
    Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umea University, Umea, Sweden
    Environ Health Perspect 120:431-6. 2012
    ..5 μm (PM(2.5); fine fraction) are documented in many studies, the effects of coarse PM (PM(2.5-10)) are still under debate...
  50. ncbi Hydrogen sulfide and particle matter levels associated with increased dispensing of anti-asthma drugs in Iceland's capital
    Hanne Krage Carlsen
    Centre of Public Health Sciences, School of Health Sciences, University of Iceland, Stapi v Hringbraut, 101 Reykjavik, Iceland
    Environ Res 113:33-9. 2012
    ..Respiratory health effects of exposure to PM and traffic pollutants are well documented, yet this is one of the first studies to investigate short-term health effects of ambient H2S exposure...
  51. ncbi Kinetics of membrane damage to high (HNA) and low (LNA) nucleic acid bacterial clusters in drinking water by ozone, chlorine, chlorine dioxide, monochloramine, ferrate(VI), and permanganate
    Maaike K Ramseier
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, CH 8600 Duebendorf, Switzerland
    Water Res 45:1490-500. 2011
    Drinking water was treated with ozone, chlorine, chlorine dioxide, monochloramine, ferrate(VI), and permanganate to investigate the kinetics of membrane damage of native drinking water bacterial cells...
  52. ncbi Oxidative damage in substantia nigra and striatum of rats chronically exposed to ozone
    Naira Pereyra-Muñoz
    Physiology Department, Faculty of Medicine, National Autonomous University of Mexico, CP 04510, AP 70 250, Mexico City, Mexico
    J Chem Neuroanat 31:114-23. 2006
    The purpose of this work was to study if chronic low-dose ozone exposure could per se induce oxidative damage to neurons of striatum and substantia nigra...
  53. ncbi Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol
    James G Wagner
    Department of Pathobiology and Diagnostic Investigation, Michigan State University, 211 Food Safety and Toxicology Building, East Lansing, MI 48824, USA
    Free Radic Biol Med 43:1176-88. 2007
    b>Ozone is a commonly encountered environmental oxidant which has been linked to asthma exacerbation in epidemiological studies. Ozone induces airway inflammation and enhances response to inhaled allergen...
  54. pmc Isoprene produced by leaves protects the photosynthetic apparatus against ozone damage, quenches ozone products, and reduces lipid peroxidation of cellular membranes
    F Loreto
    Consiglio Nazionale delle Richerche, Istituto di Biochimica ed Ecofisiologia Vegetali, Rome, Italy
    Plant Physiol 127:1781-7. 2001
    ..hypothesized on the basis of the protection offered by exogenous isoprene in nonemitting plants exposed to acute ozone doses...
  55. ncbi Ozone impacts of natural gas development in the Haynesville Shale
    Susan Kemball-Cook
    ENVIRON International Corporation, 773 San Marin Drive, Novato, California 94998, United States
    Environ Sci Technol 44:9357-63. 2010
    ..within the Haynesville Shale is likely to be economically important but may also generate significant emissions of ozone precursors...
  56. ncbi The role of ozone-reactive compounds, terpenes, and green leaf volatiles (glvs), in the orientation of Cotesia plutellae
    Delia M Pinto
    Department of Environmental Science, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    J Chem Ecol 33:2218-28. 2007
    ..Terpenes and some GLVs are readily oxidized by ozone (O(3)), an important oxidant of the low atmosphere and predicted to increase as a result of anthropogenic activity...
  57. ncbi Bond strength of fiber posts after the application of erbium:yttrium-aluminum-garnet laser treatment and gaseous ozone to the root canal
    Kerstin Bitter
    Department of Operative Dentistry and Periodontology, University School of Dental Medicine, CharitéCentrum 3, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Endod 34:306-9. 2008
    ..was to investigate the effects of antibacterial agents (erbium:yttrium-aluminum-garnet [Er:YAG] laser or gaseous ozone) intended to disinfect root canals on bond strengths of fiber posts compared with canals that were finally ..
  58. ncbi Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia
    Alison S Williams
    Experimental Studies Section, National Heart and Lung Institute, Imperial College London, Dovehouse St, London SW3 6LY, United Kingdom
    J Appl Physiol (1985) 103:1189-95. 2007
    Exposure to air pollutants such as ozone (O(3)) induces airway hyperresponsiveness (AHR) and airway inflammation...
  59. ncbi Augmented responses to ozone in obese carboxypeptidase E-deficient mice
    Richard A Johnston
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Regul Integr Comp Physiol 290:R126-33. 2006
    We reported previously that mice obese as a result of leptin deficiency (ob/ob) have enhanced ozone (O3)-induced airway hyperresponsiveness (AHR) and inflammation compared with wild-type (C57BL/6) controls...
  60. ncbi Controlled exposure of healthy young volunteers to ozone causes cardiovascular effects
    Robert B Devlin
    National Health and Environmental Effects, Research Laboratory MD 58D, US EPA, Research Triangle Park, NC 27711, USA
    Circulation 126:104-11. 2012
    Recent epidemiology studies have reported associations between short-term ozone exposure and mortality...
  61. ncbi Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13
    A S Williams
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Guy Scadding Building, Dovehouse St, London SW3 6LY, UK
    Eur Respir J 32:571-8. 2008
    ..whether the T-helper cell type 2-derived cytokines, interleukin (IL)-4 and -13, can modulate the lung response to ozone exposure...
  62. pmc Modeling of regional climate change effects on ground-level ozone and childhood asthma
    Perry E Sheffield
    Departments of Preventive Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Prev Med 41:251-7; quiz A3. 2011
    The adverse respiratory effects of ground-level ozone are well established. Ozone is the air pollutant most consistently projected to increase under future climate change.
  63. ncbi Growth at elevated ozone or elevated carbon dioxide concentration alters antioxidant capacity and response to acute oxidative stress in soybean (Glycine max)
    Kelly M Gillespie
    Physiological and Molecular Plant Biology Program, University of Illinois, Urbana Champaign, 1201 W Gregory Drive, Urbana, IL 61801, USA
    J Exp Bot 62:2667-78. 2011
    Soybeans (Glycine max Merr.) were grown at elevated carbon dioxide concentration ([CO(2)]) or chronic elevated ozone concentration ([O(3)]; 90 ppb), and then exposed to an acute O(3) stress (200 ppb for 4 h) in order to test the ..
  64. ncbi The role of oxidative stress and innate immunity in O(3) and endotoxin-induced human allergic airway disease
    David B Peden
    Division of Pediatric Allergy, Immunology, Rheumatology and Infectious Diseases, Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Immunol Rev 242:91-105. 2011
    b>Ozone (O(3)) and endotoxin are common environmental contaminants that cause asthma exacerbation...
  65. ncbi Particulate air pollution exposure and C-reactive protein during early pregnancy
    Pei Chen Lee
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Epidemiology 22:524-31. 2011
    ..We examined whether air pollution influences serum concentrations of C-reactive protein in early pregnancy...
  66. pmc Comparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study
    Jun Wu
    Program in Public Health and Department of Epidemiology, Anteater Instruction and Research Office, University of California, Irvine, CA 92697 3957, USA
    Environ Res 111:685-92. 2011
    ..Yet, little information exists on how effect estimates are impacted by the different exposure assessment methods employed in these studies...
  67. pmc Short-term effects of ozone air pollution on ischaemic stroke occurrence: a case-crossover analysis from a 10-year population-based study in Dijon, France
    J B Henrotin
    Stroke Register of Dijon, Neurology Department, University Hospital of Dijon, Dijon, France
    Occup Environ Med 64:439-45. 2007
    ..To evaluate the association between air pollutants and the occurrence of acute stroke from 10-year population-based study...
  68. pmc Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge
    Michelle L Hernandez
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
    Inhal Toxicol 22:648-56. 2010
    b>Ozone and lipopolysaccharide (LPS) are environmental pollutants with adverse health effects noted in both healthy and asthmatic individuals...
  69. pmc Physiological and proteomic approaches to address the active role of ozone in kiwifruit post-harvest ripening
    Ioannis S Minas
    School of Agriculture, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece
    J Exp Bot 63:2449-64. 2012
    Post-harvest ozone application has recently been shown to inhibit the onset of senescence symptoms on fleshy fruit and vegetables; however, the exact mechanism of action is yet unknown...
  70. pmc TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation
    Stavros Garantziotis
    National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA
    Am J Respir Crit Care Med 181:666-75. 2010
    b>Ozone is a common environmental air pollutant that contributes to hospitalizations for respiratory illness. The mechanisms, which regulate ozone-induced airway hyperresponsiveness, remain poorly understood...
  71. ncbi Overexpression of monodehydroascorbate reductase in transgenic tobacco confers enhanced tolerance to ozone, salt and polyethylene glycol stresses
    Amin Elsadig Eltayeb
    Laboratory of Plant Biotechnology, Faculty of Agriculture, Tottori University, Koyama, Tottori 680 8553, Japan
    Planta 225:1255-64. 2007
    ..transgenic plants showed enhanced stress tolerance in term of significantly higher net photosynthesis rates under ozone, salt and polyethylene glycol (PEG) stresses and greater PSII effective quantum yield under ozone and salt ..
  72. ncbi Impact of ozone on monoterpene emissions and evidence for an isoprene-like antioxidant action of monoterpenes emitted by Quercus ilex leaves
    Francesco Loreto
    CNR Istituto di Biologia Agroambientale e Forestale, Monterotondo Scalo, Italy
    Tree Physiol 24:361-7. 2004
    ..We exposed Q. ilex leaves to either mild and repeated ozone exposure (Experiment I) or to a single acute ozone exposure (Experiment II) at temperatures ranging between 20 and ..
  73. pmc Pulmonary inflammation induced by subacute ozone is augmented in adiponectin-deficient mice: role of IL-17A
    David I Kasahara
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 188:4558-67. 2012
    Pulmonary responses to ozone, a common air pollutant, are augmented in obese individuals. Adiponectin, an adipose-derived hormone that declines in obesity, has regulatory effects on the immune system...
  74. pmc Apoptosis induced by ozone and oxysterols in human alveolar epithelial cells
    Beata Kosmider
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Free Radic Biol Med 48:1513-24. 2010
    The mechanism of ozone-induced lung cell injury is poorly understood. One hypothesis is that ozone induces lipid peroxidation and that these peroxidated lipids produce oxidative stress and DNA damage...
  75. ncbi Estimating the national public health burden associated with exposure to ambient PM2.5 and ozone
    Neal Fann
    U S Environmental Protection Agency, Office of Air Quality Planning and Standards, Research Triangle Park, NC, USA
    Risk Anal 32:81-95. 2012
    Ground-level ozone (O(3)) and fine particulate matter (PM(2.5)) are associated with increased risk of mortality. We quantify the burden of modeled 2005 concentrations of O(3) and PM(2.5) on health in the United States...
  76. ncbi Yield and nutritive quality of sericea lespedeza (Lespedeza cuneata) and little bluestem (Schizachyrium scoparium) exposed to ground-level ozone
    M C Powell
    Department of Animal Sciences, Auburn University, AL 36849 5415, USA
    Environ Pollut 122:313-22. 2003
    ..duplicate OTCs per treatment) was ventilated with either air that had been carbon-filtered (CF) to remove ambient ozone (O3); non-filtered (NF), representative of ambient air; or enriched to twice-ambient O3 concentration (2X)...
  77. ncbi Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation
    Richard A Johnston
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Appl Physiol (1985) 104:1727-35. 2008
    We previously reported that genetically obese mice exhibit innate airway hyperresponsiveness (AHR) and enhanced ozone (O(3))-induced pulmonary inflammation...
  78. ncbi Effect of antioxidant supplementation on ozone-induced lung injury in human subjects
    J M Samet
    Human Studies Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, USA
    Am J Respir Crit Care Med 164:819-25. 2001
    To determine whether antioxidants can influence human susceptibility to ozone (O(3))-induced changes in lung function and airway inflammation, we placed 31 healthy nonsmoking adults (18 to 35 yr old) on a diet low in ascorbate for 3 wk...
  79. pmc Outdoor air pollutants and patient health
    Robert J Laumbach
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Am Fam Physician 81:175-80. 2010
    ..The two air pollutants that most commonly exceed standards are ozone and particulate matter...
  80. pmc Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels
    Thomas E Taylor-Clark
    Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD, USA
    J Physiol 588:423-33. 2010
    Inhalation of ozone is a major health risk in industrialized nations...
  81. ncbi Oxidative stress caused by ozone exposure induces loss of brain repair in the hippocampus of adult rats
    Selva Rivas-Arancibia
    Departamento de Fisiologia, Universidad Nacional Autonoma de Mexico, AP 70 250, CP 04510 México D F, Mexico
    Toxicol Sci 113:187-97. 2010
    Oxidative stress is involved in many neurodegenerative diseases. Chronic ozone exposure causes a secondary increase of reactive oxygen species, which cause an oxidative stress state in the organism...
  82. pmc Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice
    Stavros Garantziotis
    NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:11309-17. 2009
    b>Ozone is a common urban environmental air pollutant and significantly contributes to hospitalizations for respiratory illness. The mechanisms, which regulate ozone-induced bronchoconstriction, remain poorly understood...
  83. pmc Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children
    Ling Liu
    Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 117:668-74. 2009
    ..Air pollution is associated with respiratory symptoms, lung function decrements, and hospitalizations. However, there is little information about the influence of air pollution on lung injury...
  84. ncbi Differential regulation of the lung endothelin system by urban particulate matter and ozone
    Errol Thomson
    Healthy Environments and Consumer Safety Branch, and Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada, K1A 0K9
    Toxicol Sci 88:103-13. 2005
    Periodic elevation of ambient particulate matter and ozone levels is linked to acute cardiac morbidity and mortality...
  85. pmc Targets for crop biotechnology in a future high-CO2 and high-O3 world
    Elizabeth A Ainsworth
    Photosynthesis Research Unit, US Department of Agriculture Agricultural Research Service, Urbana, IL 61801, USA
    Plant Physiol 147:13-9. 2008
  86. ncbi The effect of air pollution on lung development from 10 to 18 years of age
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
    N Engl J Med 351:1057-67. 2004
    ..Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown...
  87. ncbi Air quality measurements for the aerosol research and inhalation epidemiology study
    D Alan Hansen
    Electric Power Research Institute, Palo Alto, CA 94304, USA
    J Air Waste Manag Assoc 56:1445-58. 2006
    ..To date, 13-, 25-, and 53-month air quality datasets have been used in epidemiologic analyses...
  88. ncbi Integrated transcriptomics, proteomics, and metabolomics analyses to survey ozone responses in the leaves of rice seedling
    Kyoungwon Cho
    Environmental Biology Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    J Proteome Res 7:2980-98. 2008
    b>Ozone (O(3)), a serious air pollutant, is known to significantly reduce photosynthesis, growth, and yield and to cause foliar injury and senescence...
  89. pmc Ambient ozone and pulmonary innate immunity
    Mashael Al-Hegelan
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, DUMC Box 103004, Durham, NC 27710, USA
    Immunol Res 49:173-91. 2011
    Ambient ozone is a criteria air pollutant that impacts both human morbidity and mortality. The effect of ozone inhalation includes both toxicity to lung tissue and alteration of the host immunologic response...
  90. pmc Modifiers of short-term effects of ozone on mortality in eastern Massachusetts--a case-crossover analysis at individual level
    Cizao Ren
    Department of Environmental Health, Harvard School of Public Health, Landmark Center, West, 4th Floor, 401 Park Street, Boston, MA 02215, USA
    Environ Health 9:3. 2010
    Substantial epidemiological studies demonstrate associations between exposure to ambient ozone and mortality...
  91. ncbi Assessing the genetic relatedness of higher ozone sensitivity of modern wheat to its wild and cultivated progenitors/relatives
    D K Biswas
    State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, 20 Nanxincun, 100093 Beijing, PR China
    J Exp Bot 59:951-63. 2008
    Modern wheat (Triticum aestivum L.) is one of the most ozone (O(3))-sensitive crops. However, little is known about its genetic background of O(3) sensitivity, which is fundamental for breeding O(3)-resistant cultivars...
  92. ncbi Sap flux in pure aspen and mixed aspen-birch forests exposed to elevated concentrations of carbon dioxide and ozone
    Johan Uddling
    School of Natural Resources and Environment, University of Michigan, Ann Arbor, MI 48109, USA
    Tree Physiol 28:1231-43. 2008
    Elevated concentrations of atmospheric carbon dioxide ([CO2]) and tropospheric ozone ([O3]) have the potential to affect tree physiology and structure and hence forest water use, which has implications for climate feedbacks...
  93. ncbi Treatment of root canal biofilms of Enterococcus faecalis with ozone gas and passive ultrasound activation
    Peter D Case
    School of Dentistry, The University of Queensland, Brisbane, Queensland, Australia
    J Endod 38:523-6. 2012
    ..This study examined the effects of gaseous ozone delivered into saline on biofilms of E...
  94. ncbi Ozone depletion and climate change: impacts on UV radiation
    R L McKenzie
    National Institute of Water and Atmospheric Research, NIWA Lauder, PB 50061, Omakau, Central Otago, New Zealand
    Photochem Photobiol Sci 10:182-98. 2011
    The Montreal Protocol is working, but it will take several decades for ozone to return to 1980 levels. The atmospheric concentrations of ozone depleting substances are decreasing, and ozone column amounts are no longer decreasing...
  95. ncbi Ozone depletion and solar ultraviolet radiation: ocular effects, a United nations environment programme perspective
    Anthony P Cullen
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Eye Contact Lens 37:185-90. 2011
    To describe he role played by the United Nations Environmental Effects Panel with respect to the ocular effects of stratospheric ozone depletion and present the essence of the Health Chapter of the 2010 Assessment.
  96. pmc Acute pulmonary function response to ozone in young adults as a function of body mass index
    William D Bennett
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Inhal Toxicol 19:1147-54. 2007
    Recent studies have shown enhanced responsiveness to ozone in obese mice. Adiposity has not been examined as a possible modulator of ozone response in humans...
  97. ncbi Effect of short-term ozone treatments on tomato (Solanum lycopersicum L.) fruit quality and cell wall degradation
    Luis Rodoni
    Centro de Investigacion y Desarrollo en Criotecnologia de Alimentos CIDCA CCT La Plata, CONICET UNLP, Calle 47 Esq 116 La Plata, Buenos Aires, CP 1900, Argentina
    J Agric Food Chem 58:594-9. 2010
    We evaluated the effect of short-term gaseous ozone treatment (10 microL/L; 10 min) on tomato fruit quality and cell wall degradation...
  98. ncbi Air pollution: a new risk factor in ischemic stroke mortality
    Yun Chul Hong
    Department of Occupational and Environmental Medicine, Inha University College of Medicine, Jung Gu, Incheon, Korea
    Stroke 33:2165-9. 2002
    ..We investigated the association between acute stroke mortality and air pollution over a 7-year period (January 1991 through December 1997) in Seoul, Korea...
  99. ncbi Does temperature modify short-term effects of ozone on total mortality in 60 large eastern US communities? An assessment using the NMMAPS data
    Cizao Ren
    School of Public Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
    Environ Int 34:451-8. 2008
    Many studies have indicated that ozone is associated with morbidity and mortality. A few studies have reported that the association is heterogeneous across seasons and geographic regions...
  100. pmc Oxidants and the pathogenesis of lung diseases
    Jonathan Ciencewicki
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 122:456-68; quiz 469-70. 2008
    ....
  101. pmc Impact of climate change on ambient ozone level and mortality in southeastern United States
    Howard H Chang
    Statistical and Applied Mathematical Sciences Institute, Research Triangle Park, NC 27709, USA
    Int J Environ Res Public Health 7:2866-80. 2010
    ..This paper examines the risks of future ozone levels on non-accidental mortality across 19 urban communities in Southeastern United States...

Research Grants72

  1. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..Program: The goal of this project is to develop a panel of biologic response markers for environmental agents (ozone, cigarette smoke, endotoxin, and allergen) that are known to perturb biologic systems resulting in changes in the ..
  2. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..Program: The goal of this project is to develop a panel of biologic response markers for environmental agents (ozone, cigarette smoke, endotoxin, and allergen) that are known to perturb biologic systems resulting in changes in the ..
  3. Genome-wide recombination as a risk factor for nondisjunction
    NATASHA D HOLLIS; Fiscal Year: 2010
    ..Education Program (PREP) student at the University of Alabama-Birmingham where her research examined the effect of ozone exposure on mitochondrial DNA damage and TNFa response in c57 mice...
  4. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..although there is likely a synergy between combustion-source particulate matter with the gas-phase oxidant ozone. Furthermore, the increased air pollution dose associated with outdoor physical activity is of substantial public ..
  5. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..5, PM10, ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide), matched to the exact locations of participants'homes...
  6. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    ..using indoor PM to dissect the effects on lungs and innate immune response without the confounding effects of ozone and other gaseous components...
  7. Air Toxics, Neighborhood Environment and Risk of Oral Clefts
    Philip J Lupo; Fiscal Year: 2013
    ..S.;and 3) there are currently no national air quality standards as there are for other air pollutants (e.g., ozone)...
  8. Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
    BRITT HOLMEN; Fiscal Year: 2010
    ..and gaseous components of the exhaust as well as the heterogeneous oxidation products upon reaction with ozone will be characterized...
  9. Air Pollution, Inflammation and Preterm Birth: A Mechanistic Study in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2012
    ..5, PM10, ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide), matched to locations of participants'homes...
  10. Genetic Determinants of Lung Injury
    Beverly H Koller; Fiscal Year: 2013
    ..of cellular metabolism, but are also produced at high levels during metabolism of environmental pollutant such as ozone (O3)...
  11. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    DEBRA LYNN LASKIN; Fiscal Year: 2012
    b>Ozone is a ubiquitous urban air pollutant known to damage the lung and compromise respiratory function...
  12. Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity
    Sven Eric Jordt; Fiscal Year: 2013
    ..of TRPV4 leads to severe lung injury and cardiovascular depression, and we show that a TRPV4 antagonist inhibits ozone induced oxidative lung edema...
  13. Impact of obesity on airway responses to air pollution
    Stephanie A Shore; Fiscal Year: 2013
    ..Obese subjects also respond to the air pollutant, ozone (O3), an asthma trigger, with greater decrements in lung function than lean individuals...
  14. Effects of ozone exposure on expression and function of surfactant protein D
    Angela Haczku; Fiscal Year: 2010
    ..Our laboratory has established murine models that mimic the pathology of ozone (O3)-induced exacerbation of airway inflammation...
  15. Environmental Determinants of Cognitive Aging in the WHI Memory Study
    Jiu Chiuan Chen; Fiscal Year: 2013
    ..Memory impairments have been demonstrated in animal models exposed to ozone. Neurotoxicological data have shown that exposures to ambient air pollutants induce oxidative stress and ..
  16. Ozone Cardiovascular Effects in Genetically Susceptible People
    MARK WALTER FRAMPTON; Fiscal Year: 2012
    ..PM) exposure, we know very little about the possible cardiovascular effects of the oxidant gaseous pollutant, ozone. We hypothesize that ozone exposure delivers an oxidative burden to the lung and to the vascular endothelium, via ..
  17. International Training and Research in Environmental and Occupational Health
    NELSON K STEENLAND; Fiscal Year: 2012
    ..Outdoor air pollution is also a large problem, due to both particulates in the air, high ozone, and lead...
  18. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
    ..exposures of human subjects to low levels of environmental toxicants, such as ambient particulate matter, ozone, or diesel exhaust, provide an opportunity to help augment animal studies and population-based studies to better ..
  19. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    ..Violet (UV) irradiation;chemical inactivation utilizing hydrolyzable compounds such as 2- proprionolactone and ozone;and photochemical decontamination using synthetic psoralens...
  20. Ozone, apoE4, aging, and Alzheimer's disease
    Rui Ming Liu; Fiscal Year: 2013
    ..b>Ozone (O3) is a highly reactive gas and one of the most abundant urban pollutants with over 30% of the population in the ..
  21. A New Low Power Low Cost Ozone Sterilizer for Medical Equipment
    Joseph R Stetter; Fiscal Year: 2012
    ..proposes to combine our years of experience with ozone generation and sensing technology with the NIH SBIR program to develop novel technology for the sterilization of ..
  22. Preventing Burn Wound Infection Using a Novel Free Radical Sterilization System
    BENJAMIN DAVID SADOWITZ; Fiscal Year: 2011
    ..novel free radical sterilization system by combining non-thermal plasma processing with hydrogen peroxide and ozone technologies...
  23. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2012
    ..Animals were treated with approximately 13 different chemical agents (ovalbumin, , ozone, hyperoxia, 2,3-butanedione, acetoin, 2,3-pentanedione, benzene, indium phosphide, indium-tin-oxide, bafilomycin ..
  24. A New Point of Use Decontamination Method for Fresh Produce
    ADRIAN J DENVIR; Fiscal Year: 2010
    ..b>Ozone gas has been found to effectively eliminate microorganisms on food surfaces...
  25. Air Pollution and Cognitive Aging Among Older Women
    Jennifer Weuve; Fiscal Year: 2010
    ..g., ozone)...
  26. Impact of Air Pollution, Weather, and Lifestyle on Health in Older Americans
    HELEN SUH MACINTOSH; Fiscal Year: 2013
    ..We will link NSHAP data to daily and monthly PM2.5, ozone, temperature exposures that will be estimated using well- validated GIS- and satellite-based spatio-temporal ..
  27. Assessing the Cumulative Climate-Related Health Risks in the Eastern U.S.
    Yang Liu; Fiscal Year: 2011
    ..associated with three groups of climate-related stressors: direct (heat waves), proximal (air pollution including ozone and PM2.5) and distal (Lyme disease vectors as the prototype)...
  28. Air Pollution and Children's Cognitive and Health Outcomes
    Ashlesha Datar; Fiscal Year: 2013
    ..A substantial body of literature has linked exposure to criteria pollutants (particulate matter, ground-level ozone, carbon monoxide, sulfur oxides, nitrogen oxides, and lead) with adverse health outcomes in children, however, ..
  29. Space-time Modeling for Linking Climate Change,Pollutant Exposure, Built Environm
    Montserrat Fuentes; Fiscal Year: 2013
    ..We will improve upon existing approaches by simultaneously accounting for different pollutant types, such as ozone and particulate matter (PM) or speciated PM, characterizing the spatial temporal structure of the susceptible ..
  30. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2011
    Keywords inhalation exposure;oropharyngeal aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke, diacetyl, 2,3-pentanedione, benzene...
  31. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2010
    Keywords inhalation exposure;oropharyngeal aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke, diacetyl, 2,3-pentanedione, benzene...
  32. Genes, Air Pollution, Oxidant Stress, Inflammation and Children's Resp
    Frank D Gilliland; Fiscal Year: 2011
    ..25], PM[0.25-2.50, and PM[2.5-10] characteristics, constituents), ozone and nitrogen dioxide...
  33. Down-regulation of oxidant-induced airway inflammation though modulation of NRF2
    Michelle Hernandez; Fiscal Year: 2013
    ..4 parts per million (ppm) ozone (O3)...
  34. Obesity and Environmental Lung Disease: The Role of Chemerin
    RICHARD ALAN JOHNSTON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obesity enhances decrements in pulmonary function induced by exposure to ozone (O3), a common environmental pollutant. However, the mechanistic basis underlying this relationship is poorly understood...
  35. Inflammatory Cytokine Polymorphisms, Air Pollution, and Very Preterm Birth
    Ondine von Ehrenstein; Fiscal Year: 2013
    ..Study, a nested case-control study of VPTB from 5 counties in Southern CA known for high particulate matter, ozone, and traffic exposures...
  36. Resolution of ozone induced lung injury requires gamma/delta T cells
    Joel A Mathews; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Exposure to ozone (O3), a common air pollutant, causes cough, dyspnea, reductions in lung function, increased susceptibility to lung infections, hospitalizations, increased asthma attacks, and even ..
  37. NQO1: Linking Oxidant Stress to Inflammation in Airway Epithelial Cells
    Judith A Voynow; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Individual responses to ozone vary widely with some individuals having a much lower threshold of ozone sensitivity for pulmonary toxicity...
  38. Air pollution exposure and COPD in the Framingham Heart Study
    Mary B Rice; Fiscal Year: 2013
    ..We hypothesize that elevations in short-term exposure to air pollutants (fine particulate matter, black carbon, ozone, nitrogen oxides, sulfates and metals) will impair lung function by spirometry and DLCO after adjustment for ..
  39. Phase II studies of gamma tocopherol as an intervention for environmental asthma
    David B Peden; Fiscal Year: 2013
    ..b>Ozone (O3) is the most commonly encountered ambient air pollutant in the US...
  40. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2009
    Keywords inhalation exposure;oropharyngeal aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke...
  41. Air Pollution, Intima-media Thickness, and Lung Function in College Students
    Edward Avol; Fiscal Year: 2010
    ..5), nitrogen- dioxide (NO2) and ozone (O3) concentrations to each residence across lifetime...
  42. Identifying components of Toxoplasma oocysts that confer environmental resistance
    HEATHER MICHELLE FRITZ; Fiscal Year: 2013
    ..The goal of this project is to understand the critical components in the oocyst that make it resistant to methods of water treatment, including chlorine, UV and ozone.
  43. PULMONARY EFFECTS OF ENVIRONMENTAL OXIDANT POLLUTANTS
    DALLAS MELVIN HYDE; Fiscal Year: 2010
    ..years of funding, the investigators have made a number of startling discoveries regarding the effect of chronic ozone exposure on lung development and growth during infancy, including: stunting of airway growth, postnatal loss of ..
  44. Impact of Climate-Responsive Design on Heat-Related Morbidity and Mortality in La
    Brian Stone; Fiscal Year: 2011
    ..Estimate regional concentrations of tropospheric ozone (O3) and fine particulate matter (PM2...
  45. Ozone Primes Pulmonary Innate Immunity
    John W Hollingsworth; Fiscal Year: 2012
    DESCRIPTION (provided by applicant) Ambient ozone is associated with increased respiratory illness, hospitalizations, and cardiovascular mortality...
  46. Tracking Air Pollutants and Newborn Health in Houston, Texas
    Elaine Symanski; Fiscal Year: 2011
    ..commissioned by Houston Mayor Bill White pointed to "definite" health risks associated with ambient air levels of ozone and fine particulates (PM2.5)...
  47. Smart Miniaturized personal monitors for black carbon and multiple air pollutants
    Steven N Chillrud; Fiscal Year: 2010
    ..analysis, (3) have one additional channel for use in chemo-optical analysis of a relevant gas or vapor, such as ozone, and (4) log location and activity data...
  48. Formaldehyde and Other Pollutants from Ozone Reactions on Ventilation Systems
    Hugo Destaillats; Fiscal Year: 2010
    ..Chemical reactions involving ozone of outdoor origin and indoor materials are among the main sources of formaldehyde and other irritant gas-phase ..
  49. Validating the CalFit Smartphone Sensor in Two Epidemiological Investigations
    Edmund Seto; Fiscal Year: 2013
    ..combine commercially available sensors with circuit boards developed by our team to measure nitrogen dioxide and ozone in the field...
  50. Safe and Effective Extraction Process for Contaminated Foods
    ANTHONY GILETTO; Fiscal Year: 2011
    ..it can be further isolated into a non-food component and where the toxin can be aggressively detoxified using ozone gas...
  51. Role of macrophages in organophosphorus pesticide-induced airway hyperreactivity
    Pamela J Lein; Fiscal Year: 2013
    ..caused by OPs and determine whether their role changes over time, as has been observed for eosinophils in ozone-induced airway hyperreactivity...
  52. Scavenger receptors and inhaled particles
    Lester Kobzik; Fiscal Year: 2011
    ..Second, SRA-deficient mice show markedly increased inflammation in response to both an inhaled oxidant gas (ozone) and the soluble fraction of particulate air pollution (in addition to known SRA interactions with solid particles)..
  53. Extracellular Matrix, Innate Immunity, and Ozone-induced Airways Disease
    John W Hollingsworth; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ambient ozone is associated with increased hospitalizations, respiratory illness, and increased cardiovascular mortality...
  54. Quantitative proteomic profiling of reactive cysteines in oxidative stress
    Chu Wang; Fiscal Year: 2012
    ..to oxidative stress during inflammation and exposure to environmental pollutants, such as nitrogen dioxide or ozone, peroxidation of membrane lipids yields several reactive end products, among which 4-hydroxy-2-nonenal (HNE) is a ..
  55. Ambient Air Pollution and Incident Stroke
    Gregory A Wellenius; Fiscal Year: 2013
    ..5 component species, gaseous pollutants (CO, NO2, SO2, and ozone) and specific air pollution sources;and delineation of the time scale of effects...
  56. Mechanisms of Species-Dependent Environmental Lung Injury
    Edward M Postlethwait; Fiscal Year: 2010
    ..Approximately half of the United States population continues to be impacted by pathogenic air pollutants such as ozone (O3), which recent epidemiologic studies suggest induces long term functional impairments in children...
  57. Children's Health and Vulnerability to Heat and Ozone in New York City
    Perry Elizabeth Sheffield; Fiscal Year: 2013
    ..high-resolution spatial and temporal models that will enable us to estimate neighborhood-specific ground-level ozone and surface temperature levels, and (2) Link these estimated exposures to population-based data on childhood ..
  58. Uncertainties in Modeling Spatially-Resolved Climate Change Health Impacts
    Yang Liu; Fiscal Year: 2012
    ..5, ozone and heat waves, along the east coast of U.S...
  59. Pediatric asthma, photochemical oxidant air pollutants, and climate change vulner
    Ralph J Delfino; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Photochemical oxidant air pollutants such as ozone (O3) are anticipated to increase with global warming...
  60. Development of a High Performance Bioprocess for Eliminating 1,4-Dioxane in Water
    Joseph Salanitro; Fiscal Year: 2012
    ..There are only two routes of eliminating 1,4- dioxane in water: UV or hydrogen peroxide coupled with ozone oxidation (i.e. advanced oxidation), and biological degradation...
  61. SP-A as an immune modulator
    Monica Kraft; Fiscal Year: 2013
    ..These projects will employ specific environmental challenges (infection and ozone exposure) to test the ability of SP-A to modulate allergic inflammation in asthma, and whether allelic variants of ..
  62. Mechanisms of Air Pollution Health Effects in Subjects with Heart Failure
    Gregory A Wellenius; Fiscal Year: 2011
    ..of traffic-related pollution), sulfates (a measure of regional pollution), gaseous pollutants (CO, N02, S02, ozone), and meteorologic data...
  63. OZONE INDUCED AIRWAY EPITHELIAL HYPERPROLIFERATION
    CHRISTOPHER MURLAS; Fiscal Year: 1999
    ..In certain airway disorders, including those due to oxidants such as ozone, endogenous airway NEP activity is decreased...
  64. LUNG DRUG DELIVERY WITH CARBON DIOXIDE AEROSOL INHALERS
    Brian Hansen; Fiscal Year: 2009
    ..CFC) propellants, but these are in the process of being phased out by the EPA and FDA due to their high ozone depletion potential (ODP)...
  65. NEUROGENIC INFLAMMATION IN ASTHMA AND OZONE LUNG INJURY
    Gary Hoyle; Fiscal Year: 2000
    ..Airborne pollutants, including ozone, have been reported to worsen asthma and associated inflammation, but the mechanisms by which pollutants ..
  66. LUNG SURFACE ANTIOXIDANT DEFENSES AGAINST AIR POLLUTANTS
    CARROLL CROSS; Fiscal Year: 2000
    ..applicant's abstract): The respiratory tract is commonly exposed to a variety of oxidizing air pollutants, such as ozone, nitrogen dioxide or cigarette smoke, which can induce inflammatory responses in the respiratory tract, and result ..
  67. MULTIDAY EXPOSURE TO O3 IN ASTHMA
    John Balmes; Fiscal Year: 2002
    ..laboratory suggest that persons with asthma have an enhanced inflammatory response to short-term inhalation of ozone. It is not known, however, whether there is progression of the inflammatory response in asthmatic persons with ..
  68. ROLE OF CYTOKINE METABOLISM IN OZONE IMMUNOTOXICITY
    Judith Zelikoff; Fiscal Year: 2001
    ..The objective of this study is to determine the effect from ozone (O3) exposure on critical aspects of pulmonary macrophage (PAM) activity involved in induction of the cell-..
  69. DAMAGED DNA AND REPAIR
    Chulhee Kang; Fiscal Year: 1999
    ..In the past few years, great concern has arisen because of evidence that the ozone layer, which shields us from ultraviolet light, is slowly being depleted...
  70. OZONE EXPOSURE AND DOSE DELIVERED TO HUMAN LUNGS
    James Ultman; Fiscal Year: 2002
    DESCRIPTION: (Adapted from the Investigator's Abstract) Ozone is a ground-level air pollutant generated primarily by the photochemical reaction of automobile emissions...
  71. NUV RESISTANCE-- FUR-DEPENDENT REGULATION OF RPOS.
    JAMES HOERTER; Fiscal Year: 2000
    The depletion of the global stratospheric ozone shield is leading to a rise in the level of near-ultraviolet radiation (UVB-290-320 nm) reaching the earth's surface...
  72. Point Source Ozonation to Minimize Antibiotic Resistance
    SCOTT OSBORN; Fiscal Year: 2009
    In this Phase II project, BlueInGreen, LLC will build a hypersaturated dissolved ozone (HYDOZTM) unit to deploy in a large pilot-scale study at Springdale Wastewater Treatment Facility (SWWTF) in Springdale, Arkansas...