nitrogen dioxide

Summary

Summary: Nitrogen oxide (NO2). A highly poisonous gas. Exposure produces inflammation of lungs that may only cause slight pain or pass unnoticed, but resulting edema several days later may cause death. (From Merck, 11th ed) It is a major atmospheric pollutant that is able to absorb UV light that does not reach the earth's surface.

Top Publications

  1. pmc Nitrogen dioxide levels estimated from land use regression models several years apart and association with mortality in a large cohort study
    Giulia Cesaroni
    Department of Epidemiology, Lazio Regional Health Service, Via S, Costanza 53, 00198 Rome, Italy
    Environ Health 11:48. 2012
  2. ncbi Air pollution and health
    Bert Brunekreef
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD, Utrecht, Netherlands
    Lancet 360:1233-42. 2002
  3. ncbi The relationship between diabetes mellitus and traffic-related air pollution
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    J Occup Environ Med 50:32-8. 2008
  4. ncbi Air pollution, blood pressure, and the risk of hypertensive complications during pregnancy: the generation R study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 57:406-12. 2011
  5. ncbi Effects of nitrogen dioxide on human health: systematic review of experimental and epidemiological studies conducted between 2002 and 2006
    Ute Latza
    Institute for Occupational Medicine and Maritime Medicine ZfAM, University of Hamburg, Hamburg State Department for Social Affairs, Family, Health, and Consumer Protection, Hamburg, Germany
    Int J Hyg Environ Health 212:271-87. 2009
  6. pmc Estimated acute effects of ambient ozone and nitrogen dioxide on mortality in the Pearl River Delta of southern China
    Yebin Tao
    SKJ Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, and Centre for Environment and Health, Peking University, Beijing, China
    Environ Health Perspect 120:393-8. 2012
  7. pmc Indoor air pollution in developing countries: a major environmental and public health challenge
    N Bruce
    Department of Public Health, University of Liverpool, England
    Bull World Health Organ 78:1078-92. 2000
  8. pmc Effect of early life exposure to air pollution on development of childhood asthma
    Nina Annika Clark
    School of Population and Public Health, University of British Columbia, British Columbia, Canada
    Environ Health Perspect 118:284-90. 2010
  9. pmc Air pollution and hospital admissions for respiratory and cardiovascular diseases in Hong Kong
    T W Wong
    Department of Community and Family Medicine, Chinese University of Hong Kong
    Occup Environ Med 56:679-83. 1999
  10. pmc Childhood incident asthma and traffic-related air pollution at home and school
    Rob McConnell
    University of Southern California, Los Angeles, California, USA
    Environ Health Perspect 118:1021-6. 2010

Detail Information

Publications336 found, 100 shown here

  1. pmc Nitrogen dioxide levels estimated from land use regression models several years apart and association with mortality in a large cohort study
    Giulia Cesaroni
    Department of Epidemiology, Lazio Regional Health Service, Via S, Costanza 53, 00198 Rome, Italy
    Environ Health 11:48. 2012
    ..Few studies have evaluated the stability of spatial contrasts in outdoor nitrogen dioxide (NO₂) concentration over several years...
  2. ncbi Air pollution and health
    Bert Brunekreef
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD, Utrecht, Netherlands
    Lancet 360:1233-42. 2002
    ..In this review, we discuss the evidence for adverse effects on health of selected air pollutants...
  3. ncbi The relationship between diabetes mellitus and traffic-related air pollution
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    J Occup Environ Med 50:32-8. 2008
    ..Many of the biological pathways involved could also promote diabetes mellitus (DM). We therefore investigated the association between DM prevalence and exposure to traffic-related air pollution (nitrogen dioxide [NO 2]).
  4. ncbi Air pollution, blood pressure, and the risk of hypertensive complications during pregnancy: the generation R study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 57:406-12. 2011
    ..We assessed the associations of exposure to particulate matter (PM(10)) and nitrogen dioxide (NO(2)) levels with blood pressure measured in each trimester of pregnancy and the risks of pregnancy-induced ..
  5. ncbi Effects of nitrogen dioxide on human health: systematic review of experimental and epidemiological studies conducted between 2002 and 2006
    Ute Latza
    Institute for Occupational Medicine and Maritime Medicine ZfAM, University of Hamburg, Hamburg State Department for Social Affairs, Family, Health, and Consumer Protection, Hamburg, Germany
    Int J Hyg Environ Health 212:271-87. 2009
    In order to assess health effects in humans caused by environmental nitrogen dioxide (NO(2)) a systematic review of studies in humans was conducted...
  6. pmc Estimated acute effects of ambient ozone and nitrogen dioxide on mortality in the Pearl River Delta of southern China
    Yebin Tao
    SKJ Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, and Centre for Environment and Health, Peking University, Beijing, China
    Environ Health Perspect 120:393-8. 2012
    ..pollution; however, controversy remains regarding the relationship between ambient oxidants [ozone (O₃) and nitrogen dioxide (NO₂)] and mortality, especially in Asia...
  7. pmc Indoor air pollution in developing countries: a major environmental and public health challenge
    N Bruce
    Department of Public Health, University of Liverpool, England
    Bull World Health Organ 78:1078-92. 2000
    ..A more systematic approach to the development and evaluation of interventions is desirable, with clearer recognition of the interrelationships between poverty and dependence on polluting fuels...
  8. pmc Effect of early life exposure to air pollution on development of childhood asthma
    Nina Annika Clark
    School of Population and Public Health, University of British Columbia, British Columbia, Canada
    Environ Health Perspect 118:284-90. 2010
    ..We investigated the effect of exposure to ambient air pollution in utero and during the first year of life on risk of subsequent asthma diagnosis in a population-based nested case-control study...
  9. pmc Air pollution and hospital admissions for respiratory and cardiovascular diseases in Hong Kong
    T W Wong
    Department of Community and Family Medicine, Chinese University of Hong Kong
    Occup Environ Med 56:679-83. 1999
    ..To investigate short term effects of concentrations of pollutants in ambient air on hospital admissions for cardiovascular and respiratory diseases in Hong Kong...
  10. pmc Childhood incident asthma and traffic-related air pollution at home and school
    Rob McConnell
    University of Southern California, Los Angeles, California, USA
    Environ Health Perspect 118:1021-6. 2010
    ..Traffic-related air pollution has been associated with adverse cardiorespiratory effects, including increased asthma prevalence. However, there has been little study of effects of traffic exposure at school on new-onset asthma...
  11. ncbi Effect of outdoor and indoor nitrogen dioxide on respiratory symptoms in schoolchildren
    M Shima
    Department of Public Health, Chiba University School of Medicine, Chiba 260 8670, Japan
    Int J Epidemiol 29:862-70. 2000
    b>Nitrogen dioxide (NO(2)), an oxidant gas that contaminates both outdoor and indoor air, is considered to be a potential risk factor for asthma...
  12. ncbi Stroke and long-term exposure to outdoor air pollution from nitrogen dioxide: a cohort study
    Zorana J Andersen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark
    Stroke 43:320-5. 2012
    ..We examined the association between long-term exposure to traffic-related air pollution and incident and fatal stroke in a prospective cohort study...
  13. ncbi Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology
    Ohara Augusto
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    Free Radic Biol Med 32:841-59. 2002
    b>Nitrogen dioxide and carbonate radical anion have received sporadic attention thus far from biological investigators...
  14. ncbi Increase in tropospheric nitrogen dioxide over China observed from space
    Andreas Richter
    Institute of Environmental Physics, University of Bremen, Otto Hahn Allee 1, D 28359 Bremen, Germany
    Nature 437:129-32. 2005
    ..Here we present the tropospheric column amounts of nitrogen dioxide retrieved from two satellite instruments GOME and SCIAMACHY over the years 1996-2004...
  15. pmc Investigating the dose-response relation between air pollution and total mortality in the APHEA-2 multicity project
    E Samoli
    Department of Hygiene and Epidemiology, University of Athens, Medical School, Athens 115 27, Greece
    Occup Environ Med 60:977-82. 2003
    ..Several recent studies have reported significant health effects of air pollution even at low levels of air pollutants, but in most of these studies linear non-threshold relations were assumed...
  16. ncbi Associations between measures of socioeconomic position and chronic nitrogen dioxide exposure in Worcester, Massachusetts
    Jeff D Yanosky
    Harvard School of Public Health, Boston, Massachusetts 02215, USA
    J Toxicol Environ Health A 71:1593-602. 2008
    Census block-group-specific predicted outdoor nitrogen dioxide (NO(2); a marker of traffic pollution) levels and four census block group socioeconomic position (SEP) measures were used to evaluate whether chronic exposures to traffic-..
  17. pmc Children's exposure to nitrogen dioxide in Sweden: investigating environmental injustice in an egalitarian country
    Basile Chaix
    Community Medicine and Public Health, Department of Clinical Sciences, Malmo University Hospital, S 205 02 Malmo, Sweden
    J Epidemiol Community Health 60:234-41. 2006
    ..This study examined whether children of low socioeconomic status suffered greater exposure to outdoor nitrogen dioxide than more affluent ones, both at their place of residence and at school, in a country with widespread state ..
  18. pmc Air pollution and emergency department visits for cardiac and respiratory conditions: a multi-city time-series analysis
    David M Stieb
    Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Postal locator 4903C, 269 Laurier Ave West Ottawa, Ontario, K1A 0K9, Canada
    Environ Health 8:25. 2009
    ....
  19. ncbi The impact of daily mobility on exposure to traffic-related air pollution and health effect estimates
    Eleanor Setton
    Geography Department, University of Victoria, Victoria, British Columbia, Canada
    J Expo Sci Environ Epidemiol 21:42-8. 2011
    ..Southern California), we use paired residence- and mobility-based estimates of individual exposure to ambient nitrogen dioxide, and apply error theory to calculate bias for scenarios when mobility is not considered...
  20. ncbi Ambient air pollution and congenital heart disease: a register-based study
    Payam Dadvand
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK
    Environ Res 111:435-41. 2011
    ..to ambient particulate matter with aerodynamic diameter less than 10 μm (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxide, nitric oxide (NO), ozone (O(3)), and carbon monoxide (CO) and the occurrence of congenital heart disease in ..
  21. ncbi The risk of dying on days of higher air pollution among the socially disadvantaged elderly
    Sabit Cakmak
    Health Canada, Department of Statistics, Ottawa Health Research Institute, 50 Columbine Driveway, Ottawa, Ont, Canada
    Environ Res 111:388-93. 2011
    ..The estimated mortality rate associated with ambient air pollution based on general population studies may not be applicable to certain subgroups...
  22. ncbi Relation between concentration of air pollution and cause-specific mortality: four-year exposures to nitrogen dioxide and particulate matter pollutants in 470 neighborhoods in Oslo, Norway
    Øyvind Naess
    Institute of General Practice and Community Medicine, University of Oslo, Oslo, Norway
    Am J Epidemiol 165:435-43. 2007
    This study investigated the concentration-response relation between air pollution (nitrogen dioxide and particulate matter pollutants PM(10) and PM(2.5)) and cause-specific mortality...
  23. ncbi Respiratory effects of exposure to diesel traffic in persons with asthma
    James McCreanor
    National Heart and Lung Institute, Imperial College, and Royal Brompton Hospital, London, United Kingdom
    N Engl J Med 357:2348-58. 2007
    ..We investigated the effects of short-term exposure to diesel traffic in people with asthma in an urban, roadside environment...
  24. ncbi Hydrogen sulfide and particle matter levels associated with increased dispensing of anti-asthma drugs in Iceland's capital
    Hanne Krage Carlsen
    Centre of Public Health Sciences, School of Health Sciences, University of Iceland, Stapi v Hringbraut, 101 Reykjavik, Iceland
    Environ Res 113:33-9. 2012
    ..Respiratory health effects of exposure to PM and traffic pollutants are well documented, yet this is one of the first studies to investigate short-term health effects of ambient H2S exposure...
  25. pmc Airway epithelial regulation of allergic sensitization in asthma
    Matthew E Poynter
    Department of Medicine and Vermont Lung Center, University of Vermont, Given E410A, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Pulm Pharmacol Ther 25:438-46. 2012
    ..and the participation of airway epithelial NF-κB activation therein, using examples from our own work on nitrogen dioxide (NO₂) exposure and genetic modulation of airway epithelial NF-κB activation...
  26. pmc Short-term effects of PM10 and NO2 on respiratory health among children with asthma or asthma-like symptoms: a systematic review and meta-analysis
    Gudrun Weinmayr
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Environ Health Perspect 118:449-57. 2010
    ..the short-term effects of particulate matter with aerodynamic diameter < or = 10 microm (PM10) and nitrogen dioxide (NO2) on respiratory health of asthmatic children from published panel studies, and to investigate the ..
  27. pmc Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: evidence from a novel translational in vitro model
    Meghan M Channell
    Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Toxicol Sci 127:179-86. 2012
    ..manner, we obtained plasma from healthy human volunteers before and after exposure to diesel exhaust (DE) and nitrogen dioxide (NO(2))...
  28. ncbi Ambient air levels of volatile organic compounds (VOC) and nitrogen dioxide (NO2) in a medium size city in Northern Spain
    M A Parra
    Laboratorio Integrado de Calidad Ambiental LICA, Departamento de Quimica y Edafologia, Facultad de Ciencias, Universidad de Navarra Irunlarrea 1, 31008, Pamplona, Navarra, Spain
    Sci Total Environ 407:999-1009. 2009
    Ambient concentrations of volatile organic compounds (VOC) and nitrogen dioxide (NO2) were measured by means of passive sampling at 40 sampling points in a medium-size city in Northern Spain, from June 2006 to June 2007...
  29. ncbi Modeling the intraurban variability of ambient traffic pollution in Toronto, Canada
    M Jerrett
    Division of Environmental Health Sciences School of Public Health, University of California Berkeley, Berkeley, California 94720 7360, USA
    J Toxicol Environ Health A 70:200-12. 2007
    The objective of this paper is to model determinants of intraurban variation in ambient concentrations of nitrogen dioxide (NO2) in Toronto, Canada, with a land use regression (LUR) model...
  30. ncbi Mapping of background air pollution at a fine spatial scale across the European Union
    Rob Beelen
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    Sci Total Environ 407:1852-67. 2009
    ..This requires the ability to extrapolate from monitoring stations to unsampled locations. The aim was to assess methods to develop accurate and high resolution maps of background air pollution across the EU...
  31. ncbi Local determinants of road traffic noise levels versus determinants of air pollution levels in a Mediterranean city
    Maria Foraster
    Centre for Research in Environmental Epidemiology CREAL, Barcelona Biomedical Research Park, Dr Aiguader, 88 08003 Barcelona, Spain
    Environ Res 111:177-83. 2011
    ..Few studies have investigated their correlation - none in Spain - and results differ among cities...
  32. pmc Characterization of source-specific air pollution exposure for a large population-based Swiss cohort (SAPALDIA)
    L J Sally Liu
    Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland
    Environ Health Perspect 115:1638-45. 2007
    ..Although the dispersion model approach has been used in some epidemiologic studies to examine health effects of traffic-specific air pollution, no study has evaluated the model predictions vigorously...
  33. ncbi Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study
    Zorana J Andersen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Am J Respir Crit Care Med 183:455-61. 2011
    ..Short-term exposure to air pollution has been associated with exacerbation of chronic obstructive pulmonary disease (COPD), whereas the role of long-term exposures on the development of COPD is not yet fully understood...
  34. ncbi Traffic-related air pollution, preterm birth and term birth weight in the PIAMA birth cohort study
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Environ Res 111:125-35. 2011
    ..Maternal exposure to air pollution has been associated with adverse pregnancy outcomes. Few studies took into account the spatial and temporal variation of air pollution levels...
  35. pmc Association of traffic-related air pollution with children's neurobehavioral functions in Quanzhou, China
    Shunqin Wang
    Department of Occupational and Environmental Health Science, School of Public Health, Peking University, Beijing, People s Republic of China
    Environ Health Perspect 117:1612-8. 2009
    ..Many chemicals from traffic exhaust, such as carbon monoxide, nitrogen dioxide, and lead, have been reported to show adverse effects on neurobehavioral functions...
  36. ncbi An air pollution model for use in epidemiological studies: evaluation with measured levels of nitrogen dioxide and benzene
    O Raaschou-Nielsen
    Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen O
    J Expo Anal Environ Epidemiol 10:4-14. 2000
    ..The model calculations were thus compared with passive sampler measurements of nitrogen dioxide and benzene at 103 street locations in Copenhagen, Denmark, and at 101 locations in rural areas...
  37. ncbi Long-term exposure to traffic-related air pollution and mortality in Shizuoka, Japan
    Takashi Yorifuji
    Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama City, Okayama Pref 700 8558, Japan
    Occup Environ Med 67:111-7. 2010
    ..Therefore, we evaluated the health effects of long-term exposure to traffic-related air pollution in Shizuoka, Japan...
  38. pmc Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain
    Ferran Ballester
    Center for Public Health Research CSISP, Conselleria de Sanitat, 46020, Valencia, Spain
    Environ Health 9:6. 2010
    ..The objective of this study was to assess the association between exposure to air pollution during pregnancy and anthropometric measures at birth in a cohort in Valencia, Spain...
  39. ncbi Associations between outdoor air pollution and emergency department visits for stroke in Edmonton, Canada
    Paul J Villeneuve
    Air Health Effects Division, Environmental Contaminants Bureau, Health Canada, 269 Laurier Ave W 3rd Floor, 3 022 PL4903C, Ottawa, Ontario, Canada, K1A 0K9
    Eur J Epidemiol 21:689-700. 2006
    ..20 (95% CI = 1.00-1.43). Our results suggest it is possible that vehicular traffic, which produces increased levels of NO(2) and CO, contributes to an increased incidence of emergency department visits for stroke...
  40. ncbi Long-term inhalable particles and other air pollutants related to mortality in nonsmokers
    D E Abbey
    Loma Linda University, Loma Linda, California 92350, USA
    Am J Respir Crit Care Med 159:373-82. 1999
    ..PM10) (1973- 1992) and other air pollutants-total suspended sulfates, sulfur dioxide, ozone (O3), and nitrogen dioxide-were related to 1977-1992 mortality in a cohort of 6,338 nonsmoking California Seventh-day Adventists...
  41. ncbi Long-term exposure to air pollution and vascular damage in young adults
    Virissa Lenters
    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Epidemiology 21:512-20. 2010
    ..There are, however, very limited data in healthy young people. We examined the association between air pollutants and indicators of vascular damage in a cohort of young adults...
  42. ncbi Correlation between co-exposures to noise and air pollution from traffic sources
    H W Davies
    University of British Columbia, Vancouver, Canada
    Occup Environ Med 66:347-50. 2009
    ..Similarities in pollution source and health outcome mean that there is potential for noise to confound studies of air pollution and cardiovascular disease, and vice versa, or for more complex interactions to occur...
  43. ncbi Air pollution and hospital admissions for cardiovascular disease in Taipei, Taiwan
    Chih Ching Chang
    Institute of Public Health, Kaohsiung Medical University, 100 Shin Chuan 1st Road, Kaohsiung 80708, Taiwan
    Environ Res 98:114-9. 2005
    ..associations were found between levels of particulate matter <10-microm aerodynamic diameter (PM10), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3)...
  44. ncbi Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994
    J M Samet
    Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 343:1742-9. 2000
    ..Although these findings have helped lead to a tightening of air-quality standards, their validity with respect to public health has been questioned...
  45. ncbi Air pollution: a new risk factor in ischemic stroke mortality
    Yun Chul Hong
    Department of Occupational and Environmental Medicine, Inha University College of Medicine, Jung Gu, Incheon, Korea
    Stroke 33:2165-9. 2002
    ..We investigated the association between acute stroke mortality and air pollution over a 7-year period (January 1991 through December 1997) in Seoul, Korea...
  46. ncbi Acute respiratory health effects of air pollution on children with asthma in US inner cities
    GEORGE T O'CONNOR
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 121:1133-1139.e1. 2008
    ..Children with asthma in inner-city communities may be particularly vulnerable to adverse effects of air pollution because of their airways disease and exposure to relatively high levels of motor vehicle emissions...
  47. ncbi A case study of personal exposure to nitrogen dioxide using a new high sensitive diffusive sampler
    A Piechocki-Minguy
    Ecole des Mines de Douai, 941, rue Charles Bourseul, B P 838, 59508 DOUAI Cedex, France
    Sci Total Environ 366:55-64. 2006
    ....
  48. pmc Household levels of nitrogen dioxide and pediatric asthma severity
    Kathleen Belanger
    Center for Perinatal, Pediatric and Environmental Epidemiology, Yale University School of Public Health, New Haven, CT 06510, USA
    Epidemiology 24:320-30. 2013
    Adverse respiratory effects in children with asthma are associated with exposures to nitrogen dioxide (NO2). Levels indoors can be much higher than outdoors...
  49. pmc Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease
    Rebecca A Martin
    Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 48:655-64. 2013
    b>Nitrogen dioxide (NO2) is an environmental pollutant and endogenously generated oxidant associated with the development, severity, and exacerbation of asthma...
  50. ncbi Ambient level of NO2 augments the inflammatory response to inhaled allergen in asthmatics
    C Barck
    Department of Medicine, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden
    Respir Med 96:907-17. 2002
    ..The purpose of this study was to examine how exposure to a high ambient concentration nitrogen dioxide (NO2) prior to a bronchial allergen challenge modulated the inflammatory response in the bronchi...
  51. pmc Air pollution and daily mortality in Sydney, Australia, 1989 through 1993
    G Morgan
    New South Wales Health Department, Gladesville, Australia
    Am J Public Health 88:759-64. 1998
    ..This study examined the effects of outdoor air pollutants in Sydney, Australia, on daily mortality...
  52. ncbi The effect of air pollution on lung development from 10 to 18 years of age
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
    N Engl J Med 351:1057-67. 2004
    ..Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown...
  53. ncbi Associations between short-term exposure to nitrogen dioxide and mortality in 17 Chinese cities: the China Air Pollution and Health Effects Study (CAPES)
    Renjie Chen
    School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China
    Environ Int 45:32-8. 2012
    Few multi-city studies in Asian developing countries have examined the acute health effects of ambient nitrogen dioxide (NO(2))...
  54. ncbi Ozone air pollution is associated with acute myocardial infarction
    Jean Bernard Ruidavets
    INSERM U558, Faculte de Medecine, 37 Allees Jules Guesde, 31073 Toulouse Cedex, France
    Circulation 111:563-9. 2005
    ..The objective of this study was to test the associations between air pollutants and the occurrence of acute myocardial infarction (AMI)...
  55. ncbi Nitrogen dioxide (NO(2)) pollution as a potential risk factor for developing vascular dementia and its synaptic mechanisms
    Hongyan Li
    College of Environment and Resource, Center of Environmental Science and Engineering, Shanxi University, Taiyuan, Shanxi 030006, PR China
    Chemosphere 92:52-8. 2013
    ..Our results implied that NO(2) exposure could increase the risk of VaD through inducing excitotoxicity in healthy rats but weakening synaptic plasticity directly in stroke model rats...
  56. pmc Short-term effects of ozone air pollution on ischaemic stroke occurrence: a case-crossover analysis from a 10-year population-based study in Dijon, France
    J B Henrotin
    Stroke Register of Dijon, Neurology Department, University Hospital of Dijon, Dijon, France
    Occup Environ Med 64:439-45. 2007
    ..To evaluate the association between air pollutants and the occurrence of acute stroke from 10-year population-based study...
  57. ncbi Outdoor, but not indoor, nitrogen dioxide exposure is associated with persistent cough during the first year of life
    Ana Esplugues
    CIBER Epidemiología y Salud Pública, Spain
    Sci Total Environ 409:4667-73. 2011
    ..We assessed the relation between prenatal and postnatal nitrogen dioxide (NO(2)) levels and the development of lower respiratory tract infections (LRTI), wheezing and persistent ..
  58. ncbi Indoor particles affect vascular function in the aged: an air filtration-based intervention study
    Elvira Vaclavik Bräuner
    D Institute of Public Health, Department of Environmental and Occupational Health, Øster Farimagsgade 5A, DK 1014 Copenhagen K, Denmark
    Am J Respir Crit Care Med 177:419-25. 2008
    ..Exposure to particulate matter is associated with risk of cardiovascular events, possibly through endothelial dysfunction, and indoor air may be most important...
  59. ncbi An analysis of asthma hospitalizations, air pollution, and weather conditions in Los Angeles County, California
    Paul L Delamater
    Department of Geography at the Michigan State University, East Lansing, MI 48824 1222, USA
    Sci Total Environ 425:110-8. 2012
    ..County-wide measures of carbon monoxide (CO), nitrogen dioxide (NO(2)), ozone (O(3)), particulate matter<10 μm (PM(10)), particulate matter<2.5 μm (PM(2...
  60. ncbi Influence of outdoor NO2 exposure on asthma in childhood: meta-analysis
    Yukiko Takenoue
    Department of Pediatrics, Advanced Medical Research Center, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
    Pediatr Int 54:762-9. 2012
    ..The aim of the current study was to clarify this relationship for one factor by means of a meta-analysis of studies investigating the influence of NO(2) exposure on symptomatology of childhood asthma...
  61. ncbi Mechanistic studies on the reaction between cob(II)alamin and peroxynitrite: evidence for a dual role for cob(II)alamin as a scavenger of peroxynitrous acid and nitrogen dioxide
    Riya Mukherjee
    Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, USA
    Chemistry 17:11805-12. 2011
    ..Given that protein-bound Cbl is accessible to small molecules, it is likely that enzyme-bound and free intracellular Cbl(II) molecules are rapidly oxidized to inactive Cbl(III) upon exposure to peroxynitrite or (.)NO(2)...
  62. pmc Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort
    Marie Abele Bind
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 23:332-40. 2012
    ..Mechanisms and sources of susceptibility are still unclear. One possibility is that these associations can be modified by DNA methylation states...
  63. pmc Air pollution and emergency department visits for otitis media: a case-crossover study in Edmonton, Canada
    Roger Zemek
    Children s Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario, Canada
    Environ Health Perspect 118:1631-6. 2010
    ..Otitis media (OM) is one of the most common early childhood infections, resulting in an enormous economic burden to the health care system through unscheduled doctor visits and antibiotic prescriptions...
  64. ncbi Influence of socioeconomic deprivation on the relation between air pollution and beta-agonist sales for asthma
    Olivier Laurent
    Laboratoire d Etude et de Recherche en Environnement et Santé, Ecole des hautes études en santé publique, avenue du Pr Leon Bernard, Rennes Cedex, France
    Chest 135:717-23. 2009
    ....
  65. ncbi Effect of dust storm events on daily emergency admissions for respiratory diseases
    Wilson W S Tam
    School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong
    Respirology 17:143-8. 2012
    ..The harmful effect of dust storm on lung health is controversial. This study aimed to assess any associations between dust storms and emergency hospital admissions due to respiratory disease in Hong Kong...
  66. pmc Air pollution and emergency hospital admissions for cardiovascular diseases in Valencia, Spain
    F Ballester
    Unit of Epidemiology and Statistics, Valencian School of Studies for Health EVES, Conselleria de Sanitat, Generalitat Valenciana, Spain
    J Epidemiol Community Health 55:57-65. 2001
    ..To estimate the short-term association between air pollution levels and emergency hospital admissions for cardiovascular diseases in Valencia, within 1994-1996 period...
  67. ncbi Acute effects of outdoor air pollution on forced expiratory volume in 1 s: a panel study of schoolchildren with asthma
    R Dales
    University of Ottawa, Ottawa, ON, Canada
    Eur Respir J 34:316-23. 2009
    ..02) decrease in bedtime FEV(1) (p = 0.027). This association persisted in two-pollutant models with ozone, nitrogen dioxide and sulphur dioxide. An IQR increase in mean daytime (08:00 h to 20:00 h) PM(2.5) of 6...
  68. pmc Spatial modeling of PM10 and NO2 in the continental United States, 1985-2000
    Jaime E Hart
    Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 117:1690-6. 2009
    ..However, many have been limited to city-specific average pollution measures or spatial or land-use regression exposure models in small geographic areas...
  69. ncbi Association of early-life exposure to household gas appliances and indoor nitrogen dioxide with cognition and attention behavior in preschoolers
    Eva Morales
    Center for Research in Environmental Epidemiology, Barcelona, Catalonia, Spain
    Am J Epidemiol 169:1327-36. 2009
    ..During the first 3 months of life, information about gas appliances at home and indoor nitrogen dioxide concentration was collected at each participant's home (n = 398, 83%)...
  70. ncbi Housing characteristics and indoor concentrations of nitrogen dioxide and formaldehyde in Quebec City, Canada
    Nicolas L Gilbert
    Air Health Effects Division, Health Canada, 269 Laurier Avenue West, PL 4903B, Ottawa, Ontario, Canada K1A 0K9
    Environ Res 102:1-8. 2006
    Concentrations of nitrogen dioxide and formaldehyde were determined in a study of 96 homes in Quebec City, Canada, between January and April 2005...
  71. pmc Oral cleft defects and maternal exposure to ambient air pollutants in New Jersey
    Elizabeth G Marshall
    Department of Epidemiology, UMDNJ School of Public Health, Piscataway, NJ 08854, USA
    Birth Defects Res A Clin Mol Teratol 88:205-15. 2010
    ..Evidence links exposure to ambient air pollution during pregnancy, particularly gaseous pollutants and particulate matter, to an increased risk of adverse reproductive outcomes though the results for birth defects have been inconsistent...
  72. pmc Ambient air pollution and birth defects in brisbane, australia
    Craig A Hansen
    National Center for Environmental Assessment, US Environmental Protection Agency, Durham, North Carolina, United States of America
    PLoS ONE 4:e5408. 2009
    ..This study examined potential associations between ambient air pollution and congenital heart defects and cleft lip or palate among births in Brisbane, Australia (1998-2004)...
  73. ncbi Ambient air pollution and risk of congenital anomalies in England, 1991-1999
    H Dolk
    Room 12L09, University of Ulster, Shore Road, Newtownabbey, Co Antrim, BT37 0QB, UK
    Occup Environ Med 67:223-7. 2010
    ..To investigate whether there is an association between risk of congenital anomaly and annual ward level exposure to air pollution in England during the 1990s...
  74. ncbi Reactivity of 2',7'-dichlorodihydrofluorescein and dihydrorhodamine 123 and their oxidized forms toward carbonate, nitrogen dioxide, and hydroxyl radicals
    Marta Wrona
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
    Free Radic Biol Med 38:262-70. 2005
    ..6 x 10(8) x M(-1) s(-1) for DCFH2 and 6.7 x 10(8) M(-1) s(-1) for DHR. Nitrogen dioxide interacted more slowly than carbonate radical with these probes: the rate constant for the interaction ..
  75. ncbi Estimation of personal NO2 exposure in a cohort of pregnant women
    Carmen Iñiguez
    Centre Superior d Investigació en Salut Pública, Conselleria de Sanidad, Avenida Cataluña 21, Valencia, Spain
    Sci Total Environ 407:6093-9. 2009
    ..Considering periods shorter than the entire pregnancy will provide us the opportunity to identify specific windows of susceptibility...
  76. ncbi Randomized controlled trial of unflued gas heater replacement on respiratory health of asthmatic schoolchildren
    Louis S Pilotto
    Department of General Practice and Flinders Centre for Epidemiology and Biostatistics, Flinders University of South Australia, Australia
    Int J Epidemiol 33:208-14. 2004
    Previous studies do not provide a clear picture of the relationship between nitrogen dioxide (NO(2)) exposure and asthma.
  77. ncbi Short-term effects of nitrogen dioxide on mortality: an analysis within the APHEA project
    E Samoli
    Dept of Hygiene and Epidemiology, University of Athens Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece
    Eur Respir J 27:1129-38. 2006
    The short-term effects of nitrogen dioxide (NO(2)) on total, cardiovascular and respiratory mortality in 30 European cities participating in the Air Pollution on Health: a European Approach (APHEA)-2 project were investigated...
  78. pmc Effect of nitrogen dioxide and ozone on the risk of dying in patients with severe asthma
    J Sunyer
    Respiratory and Environmental Research Unit, IMIM, Barcelona, Catalonia, Spain
    Thorax 57:687-93. 2002
    ....
  79. ncbi Indoor and outdoor air quality investigation at schools in Hong Kong
    S C Lee
    Department of Civil and Structural Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, People s Republic of China
    Chemosphere 41:109-13. 2000
    ..such as temperature, relative humidity (RH), carbon dioxide (CO2), sulphur dioxide (SO2), nitric oxide (NO), nitrogen dioxide (NO2), respirable particulate matter (PM10), formaldehyde (HCHO), and total bacteria counts were monitored ..
  80. ncbi Traffic-related air pollution in relation to respiratory symptoms, allergic sensitisation and lung function in schoolchildren
    M Rosenlund
    Department of Epidemiology, Rome E Local Health Authority, Rome, Italy
    Thorax 64:573-80. 2009
    ..Urban air pollution can trigger asthma exacerbations, but the effects of long-term exposure to traffic-related air pollution on lung function or onset of airway disease and allergic sensitisation in children is less clear...
  81. ncbi The relationship between particulate air pollution and emergency hospital visits for hypertension in Beijing, China
    Yuming Guo
    School of Public Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia
    Sci Total Environ 408:4446-50. 2010
    ..However, little is known about the relationship between air pollution and the onset of hypertension...
  82. ncbi Air pollution from traffic at the residence of children with cancer
    O Raaschou-Nielsen
    Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK 2100 Copenhagen 0, Denmark
    Am J Epidemiol 153:433-43. 2001
    ..Average concentrations of benzene and nitrogen dioxide (indicators of traffic-related air pollution) were calculated for the relevant period, and exposures to air ..
  83. pmc Air pollution and hospital admissions for ischemic heart disease in persons with congestive heart failure or arrhythmia
    Jennifer K Mann
    Department of Epidemiology, University of California, Berkeley, 94720, USA
    Environ Health Perspect 110:1247-52. 2002
    ..of increased vulnerability among persons with these conditions to daily variations in ozone, carbon monoxide, nitrogen dioxide, or particulate matter less than or equal to 10 micro m in aerodynamic diameter (PM10)...
  84. pmc Maternal exposure to low-level air pollution and pregnancy outcomes: a population-based study
    Ligita Maroziene
    Department of Environmental Science, Vytautas Magnus University, Vileikos 8, Kaunas, Lithuania
    Environ Health 1:6. 2002
    ..We have evaluated the relationship between ambient air pollution and the occurrence of low birth weight and preterm delivery using routinely collected data in Lithuania...
  85. pmc Traffic-related atmospheric pollutants levels during pregnancy and offspring's term birth weight: a study relying on a land-use regression exposure model
    Remy Slama
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Environ Health Perspect 115:1283-92. 2007
    ..Some studies have suggested that particulate matter (PM) levels during pregnancy may be associated with birth weight. Road traffic is a major source of fine PM (PM with aero-dynamic diameter < 2.5 microm; PM(2.5))...
  86. pmc Exposure error masks the relationship between traffic-related air pollution and heart rate variability
    Helen H Suh
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    J Occup Environ Med 52:685-92. 2010
    We examined whether more precise exposure measures would better detect associations between traffic-related pollution, elemental carbon (EC), nitrogen dioxide (NO2), and heart rate variability (HRV).
  87. ncbi Ozone, but not nitrogen dioxide, exposure decreases glutathione peroxidases in epithelial lining fluid of human lung
    N E Avissar
    Departments of Surgery, Pediatrics, Biostatistics, Medicine, and Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
    Am J Respir Crit Care Med 162:1342-7. 2000
    ..04). Thus, O(3), a strong oxidant, decreases both GPx activity and eGPx protein in ELF, whereas NO(2), a weaker oxidant, does not. eGPx in ELF may protect against O(3)-induced airway inflammation...
  88. pmc Maternal exposure to nitrogen dioxide during pregnancy and offspring birth weight: comparison of two exposure models
    Johanna Lepeule
    INSERM, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, Institut Albert Bonniot, Grenoble, France
    Environ Health Perspect 118:1483-9. 2010
    ..Studies of the effects of air pollutants on birth weight often assess exposure with networks of permanent air quality monitoring stations (AQMSs), which have a poor spatial resolution...
  89. ncbi Spatial analysis and land use regression of VOCs and NO(2) from school-based urban air monitoring in Detroit/Dearborn, USA
    Shaibal Mukerjee
    National Exposure Research Laboratory, U S Environmental Protection Agency E205 03, Research Triangle Park, NC 27711, USA
    Sci Total Environ 407:4642-51. 2009
    Passive ambient air sampling for nitrogen dioxide (NO(2)) and volatile organic compounds (VOCs) was conducted at 25 school and two compliance sites in Detroit and Dearborn, Michigan, USA during the summer of 2005...
  90. pmc Children's asthma hospitalizations and relative risk due to nitrogen dioxide (NO2): effect modification by race, ethnicity, and insurance status
    Sara E Grineski
    Department of Sociology and Anthropology, University of Texas at El Paso, TX, USA
    Environ Res 110:178-88. 2010
    ..While controlling for weather, interactions between nitrous dioxide (NO(2)) and race, ethnicity, and insurance status are used to predict relative risk for subgroups of children...
  91. pmc Traffic related pollution and heart rate variability in a panel of elderly subjects
    J Schwartz
    Department of Environmental Health, Environmental Epidemiology Program, Harvard School of Public Health, 401 Park Drive, P O Box 15677, Landmark Center, Suite 415, Boston, MA 02215, USA
    Thorax 60:455-61. 2005
    ....
  92. ncbi Long-term exposure to ambient air pollution and cardiopulmonary mortality in women
    Ulrike Gehring
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Epidemiology 17:545-51. 2006
    ..We assessed whether long-term exposure to air pollution originating from motorized traffic and industrial sources is associated with total and cause-specific mortality in a cohort of women living in North Rhine-Westphalia, Germany...
  93. ncbi SAOZ measurements of NO2 at Aberystwyth
    G Vaughan
    School of Earth, Atmospheric and Environmental Sciences, University of Manchester, M60 1QD, UK
    J Environ Monit 8:353-61. 2006
    ..Departures from the fitted curve show a trend of 6% per decade, consistent with that reported elsewhere, for the period 1998-2003, but in the past two years a distinct interannual variation of amplitude of approximately 8% has emerged...
  94. ncbi Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children
    Amne Iskandar
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Ledreborg Alle 34, 2820 Gentofte, Denmark
    Thorax 67:252-7. 2012
    ..There are no available studies on the particular effect of ultrafine particles (UFPs) on paediatric admissions for asthma...
  95. pmc Air pollution exposure estimation using dispersion modelling and continuous monitoring data in a prospective birth cohort study in The Netherlands
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 11:9. 2012
    ..The Generation R Study provides unique possibilities to examine effects of short- and long-term air pollution exposure on various maternal and childhood outcomes and to identify potential critical windows of exposure...
  96. pmc Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children
    Ling Liu
    Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 117:668-74. 2009
    ..Air pollution is associated with respiratory symptoms, lung function decrements, and hospitalizations. However, there is little information about the influence of air pollution on lung injury...
  97. pmc Personal exposure of Paris office workers to nitrogen dioxide and fine particles
    L Mosqueron
    Universite Rene Descartes, Laboratoire d Hygiéne et de Santé Publique, 4 avenue de l Observatoire, 75 006 Paris, France
    Occup Environ Med 59:550-5. 2002
    ..5)) and nitrogen dioxide (NO(2)), and to quantify their microenvironmental determinants...
  98. ncbi Field comparison of passive air samplers with reference monitors for ambient volatile organic compounds and nitrogen dioxide under week-long integrals
    Shaibal Mukerjee
    National Exposure Research Laboratory E205 02, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Environ Monit 11:220-7. 2009
    This study evaluates performance of nitrogen dioxide (NO2) and volatile organic compound (VOC) passive samplers with corresponding reference monitors at two sites in the Detroit, Michigan area during the summer of 2005...
  99. pmc Interference of a short-term exposure to nitrogen dioxide with allergic airways responses to allergenic challenges in BALB/c mice
    Barbara Proust
    Unite de Pharmacologie Cellulaire, Unité Associée Institut Pasteur INSERM U485, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mediators Inflamm 11:251-60. 2002
    b>Nitrogen dioxide (NO(2)) is a common indoor and outdoor air pollutant whose role in the induction of asthma is unclear...
  100. ncbi Shift toward an alternatively activated macrophage response in lungs of NO2-exposed rats
    Holger Garn
    Institute of Immunology, Department of Pathology, Laboratory of Lung Cell Biology, Philipps University Marburg, Marburg, Germany
    Am J Respir Cell Mol Biol 28:386-96. 2003
    ..In a rat inhalation model using continuous exposure to 10 ppm nitrogen dioxide for 1, 3, and 20 d, we investigated the inflammatory response with particular focus on the activation state ..
  101. ncbi Activity pattern and personal exposure to nitrogen dioxide in indoor and outdoor microenvironments
    C Kornartit
    Centre for Atmospheric and Instrumentation Research CAIR, University of Hertfordshire, Hatfield, Hertfordshire, AL10 9AB, UK
    Environ Int 36:36-45. 2010
    People are exposed to air pollution from a range of indoor and outdoor sources. Concentrations of nitrogen dioxide (NO(2)), which is hazardous to health, can be significant in both types of environments...

Research Grants62

  1. OZONE EXPOSURE AND DOSE DELIVERED TO HUMAN LUNGS
    James Ultman; Fiscal Year: 2002
    ..in the nose of healthy nonsmokers while these subjects are continuously exposed to clean air, ozone, nitrogen dioxide or sulfur dioxide during quite nasal breathing for two hours. 3...
  2. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..5, PM10, ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide), matched to the exact locations of participants'homes...
  3. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Respirable dust, elemental carbon, black carbon, nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), aldehydes, and polycyclic aromatic hydrocarbons (PAHs) ..
  4. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..In turn, MPO oxidizes NO2- to generate nitrogen dioxide ([unreadable]NO2), a radical that is capable of oxidizing lipids, proteins and DNA...
  5. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..cob(II)alamin, Cbl(II), and four ROS/RNS species - hydrogen peroxide, superoxide, the hydroxyl radical and nitrogen dioxide - will be studied. Kinetic and product studies will allow rates and reaction mechanisms to be elucidated...
  6. Air Pollution, Inflammation and Preterm Birth: A Mechanistic Study in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2012
    ..5, PM10, ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide), matched to locations of participants'homes...
  7. Clinical trial of air cleaners to improve indoor air quality and COPD health
    Nadia N Hansel; Fiscal Year: 2013
    ..from our research group shows that increased indoor air pollutant concentrations (particulate matter (PM) and nitrogen dioxide (NO2)) in homes of formers smokers with COPD are associated with respiratory morbidity, including increased ..
  8. Enhancement of Coronary Constriction by Volatile Organic Air Toxics
    Matthew J Campen; Fiscal Year: 2013
    ..Plasma obtained from humans exposed to diesel or nitrogen dioxide activates endothelial cells, suggesting that the transfer of toxicity from the lung to systemic vessels is ..
  9. Traffic and Respiratory Health
    Brian P Leaderer; Fiscal Year: 2013
    ..e. diesel fuel) levels of traffic-related markers, such as nitrogen dioxide (NO2) and elemental carbon (EC) will likely rise resulting in an increased risk for respiratory effects in ..
  10. Genes, Air Pollution, Oxidant Stress, Inflammation and Children's Resp
    Frank D Gilliland; Fiscal Year: 2011
    ..25], PM[0.25-2.50, and PM[2.5-10] characteristics, constituents), ozone and nitrogen dioxide. We propose to conduct a pathways-driven candidate gene-environment association study to examine the ..
  11. Exposure to mobile source air pollution and adverse birth outcomes in the Los Ang
    Jun Wu; Fiscal Year: 2009
    ..Outdoor concentrations of polycyclic aromatic hydrocarbons (PAH), nitric oxide (NO), and nitrogen dioxide (NO2) at each residence will be estimated and summarized by month and trimester for each subject...
  12. Nitro-Fatty Acids and Nrf2 in Vascular Remodeling
    Yuqing Eugene Chen; Fiscal Year: 2013
    ....
  13. Air pollution and risk of incident hypertension and diabetes in U.S. black women
    Patricia F Coogan; Fiscal Year: 2013
    ..5 <g aerodynamic diameter (PM2.5) and traffic-related pollution as indicated by nitrogen dioxide (NO2) and oxide (NO)...
  14. Endothelial Cells as Biosensors for Occupational Cardiovascular Risk
    Matthew J Campen; Fiscal Year: 2013
    ..We have already used this assay paradigm to identify cardiovascular effects of inhaled diesel emissions and nitrogen dioxide in humans exposed under controlled conditions...
  15. A Discrete Event Simulation Model of Environmental Exposures and Pediatric Asthma
    Jonathan I Levy; Fiscal Year: 2010
    ..to improve respiratory health, given their effect on pollutants such as environmental tobacco smoke, nitrogen dioxide, and indoor allergens, but such interventions often display policy-resistant tendencies...
  16. Air Pollution, Intima-media Thickness, and Lung Function in College Students
    Edward Avol; Fiscal Year: 2010
    ..Small differences in CIMT and LF at a young age translate into clinically relevant diseases, including CVD - the leading cause of mortality in the U.S. ..
  17. Oxidative pathways of guanine in DNA
    Vladimir Shafirovich; Fiscal Year: 2013
    ..sequence on the distributions of the guanine lesions generated by inflammatory ROS and RNS (peroxynitrite, nitrogen dioxide, superoxide radicals);2) Compare the base sequence-dependent formation of these lesions in naked DNA and ..
  18. Validating the CalFit Smartphone Sensor in Two Epidemiological Investigations
    Edmund Seto; Fiscal Year: 2013
    ..Aim 3, we will combine commercially available sensors with circuit boards developed by our team to measure nitrogen dioxide and ozone in the field...
  19. Nitrogen Dioxide and Light-Absorbing Carbon Sensors for Personal Exposure Assessm
    Andrew Freedman; Fiscal Year: 2010
    ..at point-of-contact of airborne species that are injurious to human health - in this particular case, nitrogen dioxide and light-absorbing carbon...
  20. Compact, wearable monitor for continuous detection of nitrogen dioxide in mines
    TIMOTHY GEORGE BURLAND; Fiscal Year: 2013
    ..In the long term, LC-based DRI's have the potential to be a broadly applicable platform technology, offering multi-analyte monitoring in the workplace. ..
  21. Quantitative proteomic profiling of reactive cysteines in oxidative stress
    Chu Wang; Fiscal Year: 2012
    ..cells are subjected to oxidative stress during inflammation and exposure to environmental pollutants, such as nitrogen dioxide or ozone, peroxidation of membrane lipids yields several reactive end products, among which 4-hydroxy-2-..
  22. Peak Indoor NO2 Concentration and Respiratory Outcomes in Children with Asthma
    LAURA MARIE PAULIN; Fiscal Year: 2013
    ..Exposure to outdoor and indoor air pollutants, including nitrogen dioxide (NO2), which is a byproduct of combustion, has been associated with worsening asthma morbidity...
  23. LUNG SURFACE ANTIOXIDANT DEFENSES AGAINST AIR POLLUTANTS
    CARROLL CROSS; Fiscal Year: 2000
    ..abstract): The respiratory tract is commonly exposed to a variety of oxidizing air pollutants, such as ozone, nitrogen dioxide or cigarette smoke, which can induce inflammatory responses in the respiratory tract, and result in lung ..
  24. TOXIC RESPONSES OF NASAL MUCOSA TO INHALED IRRITANTS
    John Morris; Fiscal Year: 2000
    ..nasal responses in the mouse and rat to four toxic irritants: acrolein, ethyl acrylate, acetaldehyde and nitrogen dioxide. In addition, the role of substance P in the immediate response to these toxicants will be studied via the ..
  25. Novel Platform for NOx Reduction from Furnaces
    DONALD STOOKEY; Fiscal Year: 2004
    ..Nitrogen oxides are collectively referred to as NOx, which is the total amount of nitric oxide (NO) and nitrogen dioxide (NO2)...
  26. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2003
    ..Of substantial concern are the potential health impacts induced by the environmental oxidants ozone (O3) and nitrogen dioxide (NO2), which likely contribute to the pathogenesis of lung disease...
  27. Air Pollution and Asthma in Southeast Louisiana
    BADIOLLAH ASRABADI; Fiscal Year: 2002
    ..of this project are to: 1) Monitor air quality including carbon monoxide (CO), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone, and Particulate Matter (PM10) in several sugarcane burning and non-burning parishes...
  28. MODULATION OF EGF-RECEPTOR SIGNALING
    Albert van Der Vliet; Fiscal Year: 2001
    ..between NO and inflammatory oxidants results in formation of more reactive nitrogen species, such as nitrogen dioxide (NO2), peroxynitrite (ONOO-) or nitryl halides, which are proposed to significantly contribute to cell and ..
  29. ROLE OF NITRIC OXIDE IN SUPEROXIDE-MEDIATED PATHOLOGY
    JOSEPH BECKMAN; Fiscal Year: 1993
    ..undergoing proton-catalyzed decomposition to form potent oxidants, which are most likely hydroxyl radical and nitrogen dioxide: (pKa=6...
  30. UTEP-UNM HSC ARCH PROGRAM ON BORDER ASTHMA
    NICHOLAS PINGITORE; Fiscal Year: 2009
    ..5, carbon nanoparticles, toxic metals, polycyclic aromatic hydrocarbons (PAHs), atmospheric ozone, nitrogen dioxide (NO2), and volatile organic compounds (VOCs), and feed these data to the Research Core...
  31. ASBESTOS AND NO2 IN ENVIRONMENTAL LUNG DISEASE
    Nicholas Heintz; Fiscal Year: 2001
    ..to mixtures of chemical and physical agents, we propose to study the effects of chrysotile asbestos and nitrogen dioxide (NO2), either alone or together, on three endpoints of exposure: cell survival, cell cycle progression, and ..
  32. ACID AEROSOL HEALTH EFFECTS IN NORTH AMERICAN CHILDREN
    FRANK SPEIZER; Fiscal Year: 1991
    ..of size fractionated particulate concentrations (for two particle size cutoff values), sulfur dioxide, nitrogen dioxide, and ozone. These measures will continue during the time of the health assessment in each community...
  33. NO2 INDUCED PEROXIDATION PRODUCTS AND AIRWAY REACTIVITY
    HENRY FORMAN; Fiscal Year: 1999
    DESCRIPTION (Adapted from the Investigator's Abstract): Exposure to elevated indoor levels of nitrogen dioxide (NO2) represent a significant health problem, most notably increased airway reactivity...
  34. DEVELOPMENT OF INSTRUMENTS TO MEASURE HUMAN EXPOSURE
    JOSEPH STETTER; Fiscal Year: 1991
    ..In this study, we will develop and test recording dosimeters for carbon monoxide, nitrogen dioxide, hydrogen sulfide, formaldehyde, and ethylene oxide...
  35. Indoor and Outdoor NO2 and Asthma Severity in Children
    Brian Leaderer; Fiscal Year: 2009
    ..Results of our ongoing studies suggest that nitrogen dioxide (NO2) associated indoors with gas appliance use and outdoors with motor vehicle emissions, at levels well ..
  36. JUVENILE LUNG--TOXICOLOGICAL MODEL FOR CHILDREN
    RONALD RASMUSSEN; Fiscal Year: 1992
    ..The rationale for the experimental plan is that (1) concentrations of indoor air pollutants (e.g., nitrogen dioxide, NO2) are often much greater than outdoors, (2) young children are repeatedly exposed to these pollutants ..
  37. EFFECTOR MOLECULES IN DEMYELINATING DISEASE
    Anne Cross; Fiscal Year: 2001
    ..Furthermore, the breakdown product of PN, nitrogen dioxide, is also highly toxic to membranes...
  38. Endotoxin, Obesity, and Asthma in NYC Head Start
    Judith Jacobson; Fiscal Year: 2005
    ..b>Nitrogen dioxide (NO2), an irritant, is also suspect because it enhances susceptibility to some infectious agents...
  39. NATIONAL COOPERATIVE INNER-CITY ASTHMA STUDY
    James Stout; Fiscal Year: 2001
    ..visits to clinics and emergency rooms); and (3) environmental measures (household dust mite concentrations, nitrogen dioxide (N02) and fine particulate matter concentrations, urinary cotinine levels, and household dampness); and (4) ..
  40. AIR POLLUTANTS AND CHRONIC RESPIRATORY DISEASE
    Gail Thomas; Fiscal Year: 1980
    ..in mice using a strain of Mycoplasma pulmonis and to determine the effects of exposure to ozone (O3) and nitrogen dioxide (NO2) on the disease...
  41. PATHOBIOLOGY OF CILIATED RESPIRATORY EPITHELIAL CELLS
    MICHAEL GABRIDGE; Fiscal Year: 1980
    ..ciliostasis and/or cytonecrosis (for example: Mycoplasma pneumoniae; toxic gases such as sulfur dioxide and nitrogen dioxide; and heavy metals such as cadmium, nickel, and chromium)...
  42. AIR DISPERSION OF CHEMICALS IN INDUSTRIAL FACILITIES
    STEPHEN ZEMBA; Fiscal Year: 1992
    ..The model will be tested using industrial data for toluene diisocyanate and nitrogen dioxide, produced in polyurethane and steel cutting industries...
  43. DETERMINANTS OF PULMONARY NO2 SURFACE INTERACTIONS
    Edward Postlethwait; Fiscal Year: 1993
    b>Nitrogen dioxide (NO2), a highly toxic oxidizing gas, is encountered by a large segment of the population...
  44. NATIONAL COOPERATIVE INNER CITY ASTHMA STUDY
    Meyer Kattan; Fiscal Year: 2001
    ..counselor intervention will be ongoing for 3 years and include modules to reduce environmental (allergens, nitrogen dioxide, environmental tobacco smoke, molds) and psychosocial risks associated with asthma, to increase adherence and ..
  45. Peroxynitrite-Induced Oxidative Damage in TBI
    Edward Hall; Fiscal Year: 2007
    ..Other work suggests that a key ROS formed by mitochondria is peroxynitrite (PON). PON-derived nitrogen dioxide (,NO2), carbonate (,CO3) and hydroxyl (,OH) radicals can cause oxidative damage to mitochondrial lipids (..
  46. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..the extent to which associations between asthma outcomes and regulated EPA criteria air pollutants such as nitrogen dioxide (NO2)are independent or attributable to other monitored criteria pollutants such as particulate matter (PM) ..
  47. ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUT
    RALPH DELFINO; Fiscal Year: 2001
    ..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
  48. MASS SPECTROMETRIC IDENTIFICATION OF NEW LIPID MEDIATORS
    Michael Balazy; Fiscal Year: 2005
    ..established, however, little is known about the processes involved in the damage to biomembrane lipids by nitrogen dioxide (NO2) radical (a product of nitric oxide oxidation)...
  49. Socioeconomic Status, Stress, Air Pollution and Asthma
    Rob McConnell; Fiscal Year: 2006
    ....
  50. Heart Attacks and Traffic Pollution
    Joel Schwartz; Fiscal Year: 2006
    ..A preliminary analysis will use retrospective data, and not obtain questionnaire data. Effect modification by diabetes, prior MI, COPD, smoking, and angina will be tested using interaction terms. ..
  51. Data Coordinating Center for Sleep Heart Health
    Marie Diener West; Fiscal Year: 2007
    ..abstract_text> ..
  52. A Genome-wide Association Study of Childhood Respiratory Outcomes
    WILLIAM GAUDERMAN; Fiscal Year: 2009
    ..End of Abstract) ..
  53. Registry Study of Parkinsons Disease in Denmark
    Beate R Ritz; Fiscal Year: 2010
    ..The proposed research cannot be performed in the US due to a lack of population PD registries that would provide access to such a large number of cases and valid methods for control recruitment from the general population. ..
  54. Ergonomic Interventions for Garment Work
    Beate Ritz; Fiscal Year: 2004
    ..This study will provide employers, employees and public agencies with evidence of the effectiveness of ergonomic interventions in order to guide health and safety policy. ..
  55. STATISTICAL APPROACHES TO THE STUDY OF GXE INTERACTIONS
    W Gauderman; Fiscal Year: 2002
    ..Successful completion of these aims will improve our understanding of how GxE interaction influences disease risk, and how we can optimally design studies and analyze data to find and characterize such genes. ..
  56. Improving Physician Adherence to Asthma Guidelines
    Gregory Diette; Fiscal Year: 2005
    ..usual generalist care; and 3) How care should be organized for management of chronic diseases. ..
  57. Association between Mortality and Long-term Exposure to Outdoor Air Pollution in
    Haidong Kan; Fiscal Year: 2010
    ..The findings of this study will fill key knowledge gap of air pollution health effects in China. ..
  58. National Assessment of the Mortality and Morbidity Effects of Tropospheric Ozone
    Michelle L Bell; Fiscal Year: 2010
    ..The goal of this work is to provide policy-makers, scientists, and the public with a better understanding of how ozone affects health in order to aid more effective decisions regarding protection of human health. ..