nitrogen oxides

Summary

Summary: Inorganic oxides that contain nitrogen.

Top Publications

  1. ncbi Traffic-related air pollution and childhood respiratory symptoms, function and allergies
    Emma Nordling
    Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    Epidemiology 19:401-8. 2008
  2. ncbi Application of land use regression to estimate long-term concentrations of traffic-related nitrogen oxides and fine particulate matter
    Sarah B Henderson
    School of Occupational and Environmental Hygiene, The University of British Columbia, Vancouver, British Columbia, Canada
    Environ Sci Technol 41:2422-8. 2007
  3. ncbi Correlation of exhaled nitric oxide with nitrogen oxides and selected cytokines in induced sputum of chronic obstructive pulmonary disease patients
    D Ziora
    Department of Lung Diseases and Tuberculosis, Medical University of Silesia, Zabrze, Poland
    J Physiol Pharmacol 58:791-9. 2007
  4. ncbi Biology of nitrogen oxides in the gastrointestinal tract
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Gut 62:616-29. 2013
  5. pmc Role of an inducible single-domain hemoglobin in mediating resistance to nitric oxide and nitrosative stress in Campylobacter jejuni and Campylobacter coli
    Karen T Elvers
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom
    J Bacteriol 186:5332-41. 2004
  6. pmc Maternal exposure to air pollution and birth outcomes
    Ebba Malmqvist
    Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 119:553-8. 2011
  7. ncbi Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study
    Zorana J Andersen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Am J Respir Crit Care Med 183:455-61. 2011
  8. pmc Lung cancer incidence and long-term exposure to air pollution from traffic
    Ole Raaschou-Nielsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Environ Health Perspect 119:860-5. 2011
  9. pmc Dissimilatory metabolism of nitrogen oxides in bacteria: comparative reconstruction of transcriptional networks
    Dmitry A Rodionov
    Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia
    PLoS Comput Biol 1:e55. 2005
  10. ncbi Correlation between co-exposures to noise and air pollution from traffic sources
    H W Davies
    University of British Columbia, Vancouver, Canada
    Occup Environ Med 66:347-50. 2009

Research Grants

Detail Information

Publications330 found, 100 shown here

  1. ncbi Traffic-related air pollution and childhood respiratory symptoms, function and allergies
    Emma Nordling
    Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    Epidemiology 19:401-8. 2008
    ..Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization...
  2. ncbi Application of land use regression to estimate long-term concentrations of traffic-related nitrogen oxides and fine particulate matter
    Sarah B Henderson
    School of Occupational and Environmental Hygiene, The University of British Columbia, Vancouver, British Columbia, Canada
    Environ Sci Technol 41:2422-8. 2007
    ..62 and were similar across traffic metrics. Resulting maps show the distribution of NO to be more heterogeneous than that of NO2, supporting the usefulness of this approach for assessing spatial patterns of traffic-related pollution...
  3. ncbi Correlation of exhaled nitric oxide with nitrogen oxides and selected cytokines in induced sputum of chronic obstructive pulmonary disease patients
    D Ziora
    Department of Lung Diseases and Tuberculosis, Medical University of Silesia, Zabrze, Poland
    J Physiol Pharmacol 58:791-9. 2007
    ..Additionally, concentrations of cytokines (IL-8, TNF-alpha, TGF-beta1, GM-CSF, Eotaxin) and nitrogen oxides (as nitrite or nitrate) (NOs) were measured in induced sputum in these patients...
  4. ncbi Biology of nitrogen oxides in the gastrointestinal tract
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Gut 62:616-29. 2013
    Throughout the human gastrointestinal tract a variety of reactive nitrogen oxides are continuously formed as a result of a complex interplay between the host, commensal bacteria and dietary factors...
  5. pmc Role of an inducible single-domain hemoglobin in mediating resistance to nitric oxide and nitrosative stress in Campylobacter jejuni and Campylobacter coli
    Karen T Elvers
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom
    J Bacteriol 186:5332-41. 2004
    ..We conclude that, unlike the archetypal single-domain globin Vgb, Cgb forms a specific and inducible defense against NO and nitrosating agents...
  6. pmc Maternal exposure to air pollution and birth outcomes
    Ebba Malmqvist
    Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 119:553-8. 2011
    ..The knowledge about air pollution effects on birth weight, prematurity, and small for gestational age (SGA) in low-exposure areas is insufficient...
  7. ncbi Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study
    Zorana J Andersen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Am J Respir Crit Care Med 183:455-61. 2011
    ..Short-term exposure to air pollution has been associated with exacerbation of chronic obstructive pulmonary disease (COPD), whereas the role of long-term exposures on the development of COPD is not yet fully understood...
  8. pmc Lung cancer incidence and long-term exposure to air pollution from traffic
    Ole Raaschou-Nielsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Environ Health Perspect 119:860-5. 2011
    ..Previous studies have shown associations between air pollution and risk for lung cancer...
  9. pmc Dissimilatory metabolism of nitrogen oxides in bacteria: comparative reconstruction of transcriptional networks
    Dmitry A Rodionov
    Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia
    PLoS Comput Biol 1:e55. 2005
    ..As the result, we demonstrate considerable interconnection between various nitrogen-oxides-responsive regulatory systems for the denitrification and NO detoxification genes and evolutionary plasticity of this transcriptional network...
  10. ncbi Correlation between co-exposures to noise and air pollution from traffic sources
    H W Davies
    University of British Columbia, Vancouver, Canada
    Occup Environ Med 66:347-50. 2009
    ..Similarities in pollution source and health outcome mean that there is potential for noise to confound studies of air pollution and cardiovascular disease, and vice versa, or for more complex interactions to occur...
  11. ncbi Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone
    Michael P Murphy
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 278:48534-45. 2003
    ..Superoxide releases iron from iron-sulfur center proteins, which then generates carbon-centered radicals that initiate lipid peroxidation, yielding breakdown products that activate UCPs...
  12. ncbi Dose-response relationships between occupational exposure to potash, diesel exhaust and nitrogen oxides and lung function: cross-sectional and longitudinal study in two salt mines
    Gabriele Lotz
    Federal Institute for Occupational Safety and Health, Berlin Office, Germany
    Int Arch Occup Environ Health 81:1003-19. 2008
    ..The effect of nitrogen monoxide (NO) and nitrogen dioxide (NO(2)) was investigated in view of the recent debate on European occupational exposure limits...
  13. ncbi L-cysteine-mediated destabilization of dinitrosyl iron complexes in proteins
    P A Rogers
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Biol Chem 276:30980-6. 2001
    ..coli cells treated with nitric oxide. We propose that l-cysteine is responsible for removing the dinitrosyl iron complexes from the nitric oxide-modified proteins into which a new iron-sulfur cluster will be reassembled...
  14. pmc Nitrite reductase of Nitrosomonas europaea is not essential for production of gaseous nitrogen oxides and confers tolerance to nitrite
    Hubertus J E Beaumont
    BioCentrum Amsterdam, Department of Molecular Cell Physiology, Vrije Universiteit, NL 1081 Amsterdam, The Netherlands
    J Bacteriol 184:2557-60. 2002
    ..This demonstrates that NirK is not essential for the production of NO and N(2)O by N. europaea. Inactivation of the putative fnr gene showed that Fnr is not essential for the expression of nirK...
  15. pmc Simultaneous molecular imaging of redox reactions monitored by Overhauser-enhanced MRI with 14N- and 15N-labeled nitroxyl radicals
    Hideo Utsumi
    Department of Bio functional Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 103:1463-8. 2006
    ..Thus, it may become a powerful tool to clarify mechanisms of disease and to monitor pharmaceutical therapy...
  16. pmc Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function
    Carlo G Tocchetti
    Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Antioxid Redox Signal 14:1687-98. 2011
    ....
  17. pmc Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling
    N Paolocci
    Division of Cardiology, Department of Medicine, and Department of Biomedical Engineering, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 98:10463-8. 2001
    ..Given its cardiac and vascular properties, NO(-) may prove useful for the treatment of cardiovascular diseases characterized by cardiac depression and elevated venous filling pressures...
  18. ncbi Membrane "lens" effect: focusing the formation of reactive nitrogen oxides from the *NO/O2 reaction
    Matías N Möller
    Laboratorio de Fisicoquímica Biológica, Facultad de Ciencias, and Center for Free Radical and Biomedical Research, Universidad de la Republica, Montevideo 11400, Uruguay
    Chem Res Toxicol 20:709-14. 2007
    ....
  19. ncbi Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin
    Swati Basu
    Department of Physics, Wake Forest University, 1834 Wake Forest Road, Winston Salem, North Carolina 27109, USA
    Nat Chem Biol 3:785-94. 2007
    ....
  20. pmc Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674
    Steve Lancel
    Cardiovascular Medicine Section, Boston University Medical Center, 88 E Newton St, Boston, MA 02118, USA
    Circ Res 104:720-3. 2009
    ..Thus, HNO increases the maximal activation of SERCA via S-glutathiolation at cysteine 674...
  21. pmc Predicting traffic-related air pollution in Los Angeles using a distance decay regression selection strategy
    Jason G Su
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA
    Environ Res 109:657-70. 2009
    ..We created the first LUR models of nitric oxide (NO), nitrogen dioxide (NO2) and nitrogen oxides (NOX) for the complex megalopolis of Los Angeles (LA), California...
  22. pmc Determination of the NOx loading of an automotive lean NOx trap by directly monitoring the electrical properties of the catalyst material itself
    Peter Fremerey
    Bayreuth Engine Research Center, Universitat Bayreuth, 95440 Bayreuth, Germany
    Sensors (Basel) 11:8261-80. 2011
    ..This may limit the practical applicability of the microwave-based NOx loading detection in lean NOx traps...
  23. ncbi Monitoring RNA base structure and dynamics using site-directed spin labeling
    Peter Z Qin
    Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
    Biochemistry 42:6772-83. 2003
    ..These results demonstrate the general utility of the 4-thiouridine/methanethiosulfonate coupling method to introduce nitroxide spin labels into RNA and the ability of the resulting label to probe local structure and dynamics...
  24. pmc Site-directed spin labeling measurements of nanometer distances in nucleic acids using a sequence-independent nitroxide probe
    Qi Cai
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089 0744, USA
    Nucleic Acids Res 34:4722-30. 2006
    ..Furthermore, distance measurement in a 42 kD DNA was demonstrated. The results establish R5 as a sequence-independent probe for global structural mapping of DNA and DNA-protein complexes...
  25. ncbi Agreement of land use regression models with personal exposure measurements of particulate matter and nitrogen oxides air pollution
    Denise Montagne
    Institute for Risk Assessment Sciences IRAS, University of Utrecht, Utrecht, The Netherlands
    Environ Sci Technol 47:8523-31. 2013
    ..5 μm (PM2.5), soot (reflectance of PM2.5), nitrogen oxides (NOx), and nitrogen dioxide (NO2)...
  26. ncbi Modeling energy use and emissions from North American shipping: application of the ship traffic, energy, and environment model
    Chengfeng Wang
    College of Marine and Earth Studies, University of Delaware, Robinson Hall, Newark, Delaware 19716, USA
    Environ Sci Technol 41:3226-32. 2007
    ..Emissions estimated by STEEM for ships within 200 nautical miles of the coastal areas of the United States are about 5 times the emissions estimated in previous studies using cargo as a proxy...
  27. ncbi Improving spatial concentration estimates for nitrogen oxides using a hybrid meteorological dispersion/land use regression model in Los Angeles, CA and Seattle, WA
    Darren Wilton
    Department of Civil and Environmental Engineering, University of Washington, 201 More Hall, Box 352700, Seattle, WA 98195 2700, United States
    Sci Total Environ 408:1120-30. 2010
    ..9 (SE=0.7) and 0.16 (SE=0.12) grams NO(X)/vehicle mile for heavy-duty and lighter-duty vehicles, respectively. These values are consistent with fleet average emission factors computed for LA with EMFAC 2007...
  28. ncbi Estimating shipping emissions in the region of the Sea of Marmara, Turkey
    Cengiz Deniz
    Department of Marine Engineering, Maritime Faculty, Istanbul Technical University, 34940 Tuzla, Istanbul, Turkey
    Sci Total Environ 390:255-61. 2008
    ..The shipping emissions in the area are 46% of NO(x), 25% of PM and 1.5% of CO of road traffic emissions in Turkey data between which and correspond to a higher level than aircraft emissions and rail emissions in Turkey...
  29. ncbi Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme
    P M Bauer
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    J Biol Chem 276:34458-64. 2001
    ..Finally S-nitrosylated ornithine decarboxylase was isolated from intact cells treated with nitric oxide, suggesting that nitric oxide may regulate ornithine decarboxylase activity by S-nitrosylation in vivo...
  30. ncbi Adsorption of nitrogen oxides on graphene and graphene oxides: insights from density functional calculations
    Shaobin Tang
    Key Laboratory of Organo Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China
    J Chem Phys 134:044710. 2011
    The interactions of nitrogen oxides NO(x) (x = 1,2,3) and N(2)O(4) with graphene and graphene oxides (GOs) were studied by the density functional theory...
  31. ncbi Orientation selection in distance measurements between nitroxide spin labels at 94 GHz EPR with variable dual frequency irradiation
    Igor Tkach
    Research Group EPR Spectroscopy, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Phys Chem Chem Phys 15:3433-7. 2013
    ..Dipolar evolution traces of a representative RNA duplex and an α-helical peptide were analysed in terms of possible bi-radical structures by considering the inherent ambiguity of symmetry-related solutions...
  32. pmc Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling
    Carlo G Tocchetti
    Cardiology Division, Johns Hopkins Medical Institutions, 720 Rutland Ave, Baltimore, MD 21205, USA
    Circ Res 100:96-104. 2007
    ..Rather, the data support HNO/thiolate interactions that enhance the activity of intracellular Ca(2+) cycling proteins. These findings suggest HNO donors are attractive candidates for the pharmacological treatment of heart failure...
  33. pmc The role of nitrogen oxides in human adaptation to hypoxia
    Denny Z Levett
    Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Sci Rep 1:109. 2011
    ..on acclimatisation to high altitude while S-nitrosothiols are initially consumed, suggesting multiple nitrogen oxides contribute to improve hypoxia tolerance by enhancing NO availability...
  34. ncbi Electron spin resonance in studies of membranes and proteins
    P P Borbat
    Baker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853-1301, USA
    Science 291:266-9. 2001
    ..We illustrate these capabilities with recent examples...
  35. ncbi Keeping the heart in balance: the functional interactions of myoglobin with nitrogen oxides
    Ulrich Flogel
    Cardiovascular Physiology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    J Exp Biol 213:2726-33. 2010
    ..As Mb is widespread throughout the fauna, the diverse oxygen-dependent interactions between Mb and nitrogen oxides may not only be of relevance for mammals but also for other vertebrates as evidenced by comparable phenotypes ..
  36. ncbi A novel profluorescent nitroxide as a sensitive probe for the cellular redox environment
    Benjamin J Morrow
    ARC Centre of Excellence for Free Radical Chemistry, School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, Qld 4001, Australia
    Free Radic Biol Med 49:67-76. 2010
    ..The reversible nature of the probe's detection mechanism offers the unique advantage of being able to monitor redox changes in both oxidizing and reducing directions in real time...
  37. ncbi Regulation of prostaglandin H2 synthase activity by nitrogen oxides
    R K Upmacis
    Department of Biochemistry, Center of Vascular Biology, Joan and Sanford I Weill Medical College of Cornell University, New York 10021, USA
    Biochemistry 38:12505-13. 1999
    ..However, other forms of NO(x)() inhibit PGHS-1. These results may have implications in the regulation of vascular function and tone in normal and atherosclerotic arteries...
  38. ncbi The palladium-catalysed copper-free Sonogashira coupling of isoindoline nitroxides: a convenient route to robust profluorescent carbon-carbon frameworks
    Daniel J Keddie
    ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Queensland University of Technology, Brisbane 4001, Australia
    Org Biomol Chem 6:3135-43. 2008
    ..Ethyne- and butadiyne-linked nitroxide dimers could also be synthesised by this cross coupling methodology...
  39. ncbi Biological toxicities of emissions from an unmodified engine fueled with diesel and biodiesel blend
    Yu Yin Liu
    Department of Environmental Engineering, National Cheng Kung University, Tainan, Taiwan
    J Environ Sci Health A Tox Hazard Subst Environ Eng 43:1735-43. 2008
    ..According to the Microtox tests results, the effect of biodiesel blending in MTT assay demonstrated higher toxicity in the semi-volatile products than the particulates...
  40. ncbi The impact of biodiesel on pollutant emissions and public health
    Robert L McCormick
    National Renewable Energy Laboratory, Golden, Colorado, USA
    Inhal Toxicol 19:1033-9. 2007
    ..Biodiesel is also shown to significantly reduce life-cycle greenhouse gas emissions in comparison to petroleum diesel...
  41. pmc The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems
    Wilmarie Flores-Santana
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Antioxid Redox Signal 14:1659-74. 2011
    ..Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent...
  42. ncbi Synthesis of profluorescent isoindoline nitroxides via palladium-catalysed Heck alkenylation
    Daniel J Keddie
    School of Physical and Chemical Sciences, Queensland University of Technology, GPO Box 2434, Q4001 Australia
    Org Biomol Chem 3:2593-8. 2005
    ..The carboxystyryl tetramethylisoindoline nitroxides demonstrate strongly suppressed fluorescence, which is revealed upon removal of the free radical by reduction or radical coupling...
  43. ncbi Nitrone inhibition of age-associated oxidative damage
    R A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
    Ann N Y Acad Sci 899:222-37. 2000
    ....
  44. ncbi Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery
    Pierre Sonveaux
    Universite Catholique de Louvain UCL, Unit of Pharmacology and Therapeutics, Brussels, Belgium
    Physiology (Bethesda) 22:97-112. 2007
    ..Delivery of SNOs by the RBC can be harnessed for therapeutic gain, and early results support the logic of this approach in the treatment of diseases as varied as cancer and neonatal pulmonary hypertension...
  45. ncbi Novel antioxidants in anthracycline cardiotoxicity
    Kalman Hideg
    Department of Organic and Medicinal Chemistry, University of Pecs, P O Box 99, 7602 Pecs, Hungary
    Cardiovasc Toxicol 7:160-4. 2007
    ..The authors herein suggest that cardioprotective molecules modified by nitroxides and their secondary amine precursors can prevent or diminish the anthracycline-induced cardiomyopathy by accumulating in cardiomiocytes...
  46. ncbi Nitroxyl (HNO): the Cinderella of the nitric oxide story
    Jennifer C Irvine
    Department of Pharmacology, Monash University, Clayton, Vic, Australia
    Trends Pharmacol Sci 29:601-8. 2008
    ..Here, we discuss the unique pharmacology of HNO versus NO* and highlight the therapeutic potential of HNO donors in the treatment of cardiovascular disease...
  47. ncbi Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite
    Katrina M Miranda
    Radiation Biology Branch, National Cancer Institute NIH, Building 10, Room B3 B69, Bethesda, MD 20892, USA
    Arch Biochem Biophys 401:134-44. 2002
    ..This study emphasizes the importance of buffer composition on chemical outcome and thus on interpretation and provides further evidence that ONOO(-) is not an intermediate formed between the reaction of O(2) and HNO produced by AS...
  48. ncbi Health effects of subchronic exposure to diesel-water-methanol emulsion emission
    M D Reed
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Toxicol Ind Health 22:65-85. 2006
    ..In general, biological findings in exposed rats and bacteria were consistent with exposure to petroleum diesel exhaust in the F344 rat and Ames assays...
  49. ncbi Immuno-spin trapping of DNA radicals
    Dario C Ramirez
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Dr, Research Triangle Park, North Carolina 27709, USA
    Nat Methods 3:123-7. 2006
    ..We also applied IST to detect DNA radicals in rat hepatocytes exposed to Cu(II) and H(2)O(2) under nonlethal conditions...
  50. pmc Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds
    Tamas Kalai
    Institute of Organic and Medicinal Chemistry, University of Pecs, Szigeti st 12, H 7624 Pecs, Hungary
    Eur J Med Chem 46:1348-55. 2011
    ....
  51. pmc Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species
    Jon M Fukuto
    Department of Chemistry, Sonoma State University, Rohnert Park, California 94928, USA
    Chem Res Toxicol 25:769-93. 2012
    ..This review focuses on this chemistry and attempts to establish the chemical basis for their signaling functions...
  52. pmc Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide. 6. Redox properties
    Frederick A Villamena
    Department of Pharmacology and Center for Biomedical EPR Spectroscopy and Imaging, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Phys Chem A 114:1153-60. 2010
    ..The preferred decomposition pathways for the one-electron oxidation and reduction of nitroxides was also explored, and formation of potentially biologically active products such as NO, H(2)O(2), and hydroxamic acid was predicted...
  53. ncbi Structure-activity relationship studies of protective function of nitroxides in Fenton system
    J Glebska
    Department of Molecular Biophysics, University of Lodz, Poland
    Biometals 14:159-70. 2001
    ..Moreover, presented data point to the danger of interference of nitroxides during the TBARS assay procedure...
  54. ncbi Effects of air pollution from road transport on growth and physiology of six transplanted bryophyte species
    Keeley L Bignal
    Department of Geography and Environmental Science, University of Bradford, Bradford BD7 1DP, UK
    Environ Pollut 156:332-40. 2008
    ..It is hypothesised that motor vehicle pollution was responsible for the effects observed, and that nitrogen oxides had a key influence...
  55. ncbi Nitric oxide release from the unimolecular decomposition of the superoxide radical anion adduct of cyclic nitrones in aqueous medium
    Edward J Locigno
    Center for Biomedical EPR Spectroscopy and Imaging, The Davis Heart and Lung Research Institute, and the Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Org Biomol Chem 3:3220-7. 2005
    ..Product analysis was also conducted to further elucidate the mechanism of adduct decay using gas chromatography-mass spectrometry (GC-MS) technique...
  56. ncbi Mechanisms underlying activation of soluble guanylate cyclase by the nitroxyl donor Angeli's salt
    Andreas Zeller
    Department of Pharmacology and Toxicology, Karl Franzens Universitat Graz, Graz, Austria
    Mol Pharmacol 76:1115-22. 2009
    ..These data indicate that AS activates sGC exclusively via NO, formed either via SOD-catalyzed oxidation of HNO or through a minor AS decomposition pathway that is unmasked in the presence of HNO scavenging thiols...
  57. ncbi Increased levels of nitrogen oxides and lipid peroxidation in the rat brain after soman-induced seizures
    S O Jacobsson
    Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden
    Arch Toxicol 73:269-73. 1999
    We have investigated the effect of soman-induced seizures on rat brain levels of nitrogen oxides (NOx) and lipid peroxidation (LPO) 30 min and 24 h after intoxication. Following administration of soman (90 microg/kg s.c...
  58. ncbi Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals
    Magdalena A Lam
    The Heart Research Institute, 114 Pyrmont Bridge Road, Camperdown, NSW, Australia
    Chem Res Toxicol 21:2111-9. 2008
    ..These reactions show little dependence on nitroxide structure or charge...
  59. ncbi Assaying all of the nitrogen oxides in breath modifies the interpretation of exhaled nitric oxide
    Thuy Anh Nguyen
    Division of Pediatric Respiratory Medicine, Asthma and Allergic Diseases Center, Box 800386, University of Virginia, Charlottesville, VA 22908, USA
    Vascul Pharmacol 43:379-84. 2005
    ..We suggest that inflammation can be better evaluated with HiNO(x) and NO measured concurrently, and that the level of oxidation in the lung can be evaluated by comparing the easily measured ratios of HiNO(x) to NO in the exhaled breath...
  60. ncbi Photocatalytic activity for degradation of nitrogen oxides over visible light responsive titania-based photocatalysts
    Yu Ming Lin
    Center for Environmental, Safety and Health Technology Development, Industrial Technology Research Institute, Room 204, Building 32, 195, Section 4, Chung Hsing Road, Chutung, Hsinchu 310, Taiwan
    Environ Sci Technol 40:1616-21. 2006
    This study investigates photocatalytic degradation of nitrogen oxides overtitania-based photocatalysts illuminated by ultraviolet and visible light...
  61. ncbi Influence of fuel properties, nitrogen oxides, and exhaust treatment by an oxidation catalytic converter on the mutagenicity of diesel engine emissions
    Jürgen Bünger
    Research Institute for Occupational Medicine of the Institutions for Statutory Accident Insurance and Prevention BGFA, Institute of the Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Arch Toxicol 80:540-6. 2006
    ..We investigated the influence of fuel properties, nitrogen oxides (NO( x )), and an oxidation catalytic converter (OCC) on the mutagenic effects of DEP...
  62. ncbi Comparative DFT study of the spin trapping of methyl, mercapto, hydroperoxy, superoxide, and nitric oxide radicals by various substituted cyclic nitrones
    Frederick A Villamena
    The Davis Heart and Lung Research Institute, and the Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Phys Chem A 109:1662-74. 2005
    ..The spin density on the nitronyl N of the superoxide adducts reveals conformational dependences. The failure of nitrones to trap NO at normal conditions was theoretically rationalized due to the endoergic reaction parameters...
  63. pmc The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols
    Thomas W Miller
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:21788-96. 2009
    ..Finally, HNO-mediated cysteine thiol modification appears to also affect enzyme activity leading to inhibition. Thus, sGC activity can be regulated by HNO via interactions at both the regulatory heme and cysteine thiols...
  64. ncbi Evidence for a physiological role of intracellularly occurring photolabile nitrogen oxides in human skin fibroblasts
    Christian Opländer
    Department of Plastic and Reconstructive Surgery, Hand Surgery, and Burn Center, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Free Radic Biol Med 44:1752-61. 2008
    ..enzymatically by NO synthases (NOS) as well as enzyme independently via photodecomposition of photolabile nitrogen oxides (PNOs) such as nitrite or nitroso compounds, both found in human skin tissue in comparably high ..
  65. pmc Hemoglobin as a nitrite anhydrase: modeling methemoglobin-mediated N2O3 formation
    Kathrin H Hopmann
    Centre for Theoretical and Computational Chemistry and Department of Chemistry, University of Tromsø, N 9037 Tromsø, Norway
    Chemistry 17:6348-58. 2011
    ....
  66. ncbi Protein radical formation on thyroid peroxidase during turnover as detected by immuno-spin trapping
    Marilyn Ehrenshaft
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 41:422-30. 2006
    ..Evidence that correlates iodine deficiencies with development of thyroid autoimmune disorders supports this conjecture...
  67. pmc Spin trapping investigation of peroxide- and isoniazid-induced radicals in Mycobacterium tuberculosis catalase-peroxidase
    Kalina Ranguelova
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 01, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 47:11377-85. 2008
    ..Furthermore, the formation of protein-DMPO nitrone adducts was accelerated in the presence of isoniazid...
  68. ncbi In situ measurements of SO2, NOx, NOy, and O3 in Beijing, China during August 2008
    Yang Sun
    State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China
    Sci Total Environ 409:933-40. 2011
    ..Lastly, the analysis of the wind direction and extent of SPM showed that the photochemical pollution of this region was mostly subject to the influence of southeastern air flow in the summer...
  69. pmc New concepts in molecular imaging: non-invasive MRI spotting of proteolysis using an Overhauser effect switch
    Philippe Mellet
    INSERM IFR 004, and Magnetic Resonance Center CNRS UMR 5536 University Victor Segalen Bordeaux, Bordeaux, France
    PLoS ONE 4:e5244. 2009
    ..Furthermore, little is known about the role of many proteases, hence there is a need of new imaging methods to visualize specifically normal or disease-related proteolysis in intact bodies...
  70. pmc Imbalance between levels of nitrogen oxides and peroxynitrite inhibitory activity in chronic obstructive pulmonary disease
    H Kanazawa
    Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Abenoku, Osaka, Japan
    Thorax 58:106-9. 2003
    ..A study was undertaken of the imbalance between the levels of nitrogen oxides and antioxidant activity against peroxynitrite in the airways of patients with COPD.
  71. ncbi Successful stabilization of the elusive species {FeNO}8 in a heme model
    Juan Pellegrino
    Departamento de Quimica Inorganica, Analitica, y Quimica Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, INQUIMAE CONICET, Ciudad Universitaria, Pab 2, C1428EHA Buenos Aires, Argentina
    J Am Chem Soc 132:989-95. 2010
    ..The enhanced stability achieved for a heme model {FeNO}(8) is expected to allow further studies related to the reactivity of this elusive species...
  72. ncbi Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells
    Kazuyoshi Kaneko
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Cancer Lett 262:239-47. 2008
    ..It also significantly increased levels of abasic sites in DNA. These observations suggest that formation of 8-nitroguanosine may contribute to the pathogenesis of inflammation-associated carcinogenesis...
  73. ncbi Electronic structure of iron(II)-porphyrin nitroxyl complexes: molecular mechanism of fungal nitric oxide reductase (P450nor)
    Nicolai Lehnert
    Institut fur Anorganische Chemie, Christian Albrechts Universitat Kiel, Olshausenstrasse 40, D 24098 Kiel, Germany
    J Comput Chem 27:1338-51. 2006
    ..The energetically disfavoured tautomer Fe(III)--N(OH2)(NO) is the catalytically productive species that spontaneously cleaves the N--OH2 bond forming N2O and H2O in a highly exergonic reaction...
  74. pmc Lung cancer and air pollution: a 27 year follow up of 16 209 Norwegian men
    P Nafstad
    Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    Thorax 58:1071-6. 2003
    ..The association between incidence of lung cancer and long term air pollution exposure was investigated in a cohort of Oslo men followed from 1972/73 to 1998...
  75. pmc Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling
    Nazareno Paolocci
    Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 100:5537-42. 2003
    ..This suggests potential of HNO/NO(-) donors for the treatment of heart failure...
  76. ncbi Long-term personal exposure to traffic-related air pollution among school children, a validation study
    Sofie van Roosbroeck
    Institute for Risk Assessment Sciences, Utrecht University, P O Box 80176, 3508 TD Utrecht, The Netherlands
    Sci Total Environ 368:565-73. 2006
    ..This finding supports the use of 'living near a busy road' as a measure of exposure in epidemiological studies on the effects of traffic-related air pollution in children...
  77. ncbi Antioxidant actions of nitroxyl (HNO)
    Brenda E Lopez
    Department of Pharmacology, Center for the Health Sciences, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1735, USA
    Free Radic Biol Med 42:482-91. 2007
    b>Nitrogen oxides are endogenously produced signaling/effector molecules that have the potential to both cause and ameliorate oxidative stress...
  78. ncbi Traffic-generated air pollution and myocardial infarction
    Mats Rosenlund
    Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    Epidemiology 20:265-71. 2009
    ..The aim of this study was to investigate the association between long-term residential exposure to air pollution from traffic and the risk of nonfatal and fatal myocardial infarction...
  79. pmc NMR, IR/Raman, and structural properties in HNO and RNO (R = alkyl and aryl) metalloporphyrins with implication for the HNO-myoglobin complex
    Yan Ling
    Department of Chemistry and Biochemistry, University of Southern Mississippi, 118 College Drive 5043, Hattiesburg, Mississippi 39406, USA
    J Am Chem Soc 132:1583-91. 2010
    ..These results should facilitate spectroscopic characterizations and structural investigations of HNO and RNO heme proteins and models...
  80. ncbi Effects of NO2 and SO2 on selective catalytic reduction of nitrogen oxides by ammonia
    Jeong Hoi Goo
    Department of Chemical and Biomolecular Engineering, Energy and Environment Research Center, Korea Advanced Institute of Science and Technology, 305 701 Daejeon, Republic of Korea
    Chemosphere 67:718-23. 2007
    ..The denitrification (DeNO(x)) conversion decreases at lower temperatures but it increases at higher temperatures with increasing SO(2) concentration. The presence of SO(2) in the feeds inhibits N(2)O formation...
  81. pmc Traffic-related air pollution associated with prevalence of asthma and COPD/chronic bronchitis. A cross-sectional study in Southern Sweden
    Anna Lindgren
    Department of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Int J Health Geogr 8:2. 2009
    ..A Geographical Information System (GIS) was used to link geocoded residential addresses to a Swedish road database and an emission database for NOx...
  82. ncbi Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping
    Ronald P Mason
    The National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 36:1214-23. 2004
    ..In time, all of the immunological techniques based on antibody-nitrone binding should become available for free radical detection in a wide variety of biological systems...
  83. ncbi Theoretical study of hydrogen bonding interaction in nitroxyl (HNO) dimer: interrelationship of the two N-H...O blue-shifting hydrogen bonds
    Ying Liu
    Key Laboratory of Environmental Optical and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, P R China
    J Phys Chem A 110:11760-4. 2006
    ..Ranging from 2.55 to 2.85 A, the cooperative ascending tendencies of the electron densities in two sigma*(N-H) with increasing r(H...O) contribute to the decreases in blue-shift degrees of nu(N-H)...
  84. ncbi Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl
    Jeffrey P Froehlich
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Biochemistry 47:13150-2. 2008
    ..We conclude that HNO produces a disulfide bond that alters the conformation of PLN, relieving inhibition of the Ca(2+) pump...
  85. pmc Nitroxyl and its anion in aqueous solutions: spin states, protic equilibria, and reactivities toward oxygen and nitric oxide
    Vladimir Shafirovich
    Chemistry Department and Radiation and Solid State Laboratory, New York University, New York 10003, USA
    Proc Natl Acad Sci U S A 99:7340-5. 2002
    ..Dimerization of (1)HNO to produce N(2)O occurred much more slowly (k = 8 x 10(6) M(-1) x s(-1)) than previously suggested. The implications of these results for evaluating the biological roles of nitroxyl are discussed...
  86. ncbi Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides
    L A Palmer
    University of Virginia Health System, Departments of Anesthesiology, Charlottesville, Virginia 22908 0710, USA
    Mol Pharmacol 58:1197-203. 2000
    ..Taken together, these results suggest that an S-nitrosylation reaction stabilizes HIF-1 protein expression and activity. We speculate that one signaling mechanism by which deoxyhemoglobin may activate HIF-1 involves NO...
  87. pmc Urban air pollution and mortality in a cohort of Norwegian men
    Per Nafstad
    Department of General Practice and Community Medicine, Medical Faculty, University of Oslo, P B 1140 Blindern, N 0317 Oslo, Norway
    Environ Health Perspect 112:610-5. 2004
    ..08 [95% confidence interval (CI), 1.06-1.11] for a 10- microg/m3 increase in average exposure to nitrogen oxides (NOx) at the home address from 1974 through 1978...
  88. pmc Site-specific radical formation in DNA induced by Cu(II)-H₂O₂ oxidizing system, using ESR, immuno-spin trapping, LC-MS, and MS/MS
    Suchandra Bhattacharjee
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 50:1536-45. 2011
    ..The DMPO adduct formed is initially EPR active but subsequently is oxidized to the stable nitrone, which can then be detected by IST and further characterized by MS and MS/MS...
  89. ncbi Indoor/Outdoor relationships, trends, and carbonaceous content of fine particulate matter in retirement homes of the Los Angeles Basin
    Andrea Polidori
    Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA 90089, USA
    J Air Waste Manag Assoc 57:366-79. 2007
    ..On average, 36% (G2P1) to 44% (G1P1) of measured indoor OC was composed of outdoor-generated primary OC...
  90. ncbi 1H NMR structure of the heme pocket of HNO-myoglobin
    Filip Sulc
    Department of Chemistry, University of California, Irvine, CA 92697 2025, USA
    J Biol Inorg Chem 8:348-52. 2003
    ..20 degrees rotation about the beta-gamma bond. The deduced HNO and His64(E7) orientations result in geometry where the His64(E7) ring can serve as the donor for a significant H-bond to the oxygen atom of the bound HNO...
  91. ncbi Efficient trapping of HNO by deoxymyoglobin
    Filip Sulc
    Department of Chemistry, University of California, Irvine, California 92697 3900, USA
    J Am Chem Soc 126:1096-101. 2004
    ..The binding of HNO to deoxymyoglobin is rapid and essentially irreversible, which suggests that the biological activity of nitroxyl may be mediated by its reactivity with ferrous heme proteins such as myoglobin and hemoglobin...
  92. pmc Ultrafine particles and nitrogen oxides generated by gas and electric cooking
    M Dennekamp
    Department of Environmental and Occupational Medicine, University of Aberdeen Medical School, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Occup Environ Med 58:511-6. 2001
    ..b>Nitrogen oxides (NO(x)) were measured by a chemiluminescent ML9841A NO(x) analyser...
  93. ncbi Nitroxyl triggers Ca2+ release from skeletal and cardiac sarcoplasmic reticulum by oxidizing ryanodine receptors
    Eunji Cheong
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cell Calcium 37:87-96. 2005
    ..The findings indicate that HNO is a more potent activator of RyR1 than NO and that HNO activation of RyRs may contribute to NO's activation of RyRs and to the therapeutic effects of HNO-releasing prodrugs in heart failure...
  94. ncbi Mass spectrometric analysis of nitroxyl-mediated protein modification: comparison of products formed with free and protein-based cysteines
    Biao Shen
    Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec, Canada H4B 1R6
    Biochemistry 44:14030-44. 2005
    ..The results provide the first systematic characterization of HNO-mediated derivatization of protein thiols...
  95. ncbi New insights into the S-nitrosothiol-ascorbate reaction. The formation of nitroxyl
    Michael Kirsch
    Institute of Physiological Chemistry, University of Essen Medical School, Hufelandstrasse 55, D 45122 Essen, Germany
    Org Biomol Chem 7:1954-62. 2009
    ..e., S-nitroso-papain). With the known chemistry of nitroxyl, it was possible to optimize the experimental conditions so that the GSNO-ascorbate reaction yielded stoichiometric amounts of glutathione after a reaction period of 1 min...
  96. pmc Personal exposure to ultrafine particles and oxidative DNA damage
    Peter S Vinzents
    Department of Occupational and Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 113:1485-90. 2005
    ..The results indicate that biologic effects of UFPs occur at modest exposure, such as that occurring in traffic, which supports the relationship of UFPs and the adverse health effects of air pollution...
  97. ncbi Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm
    David A Wink
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Rm B3 B69, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 285:H2264-76. 2003
    Endogenous formation of nitric oxide (NO) and related nitrogen oxides in the vascular system is critical to regulation of multiple physiological functions...
  98. ncbi Theoretical reduction potentials for nitrogen oxides from CBS-QB3 energetics and (C)PCM solvation calculations
    Andrew S Dutton
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095 1569, USA
    Inorg Chem 44:4024-8. 2005
    ..models for aqueous solvation to compute reduction potentials previously determined experimentally for 36 nitrogen oxides and related species of the general formula H(V)C(W)N(X)O(Y)Cl(Z)...
  99. ncbi EPR spectroscopic analysis of U7 hammerhead ribozyme dynamics during metal ion induced folding
    Thomas E Edwards
    Department of Chemistry, University of Washington, Seattle, Washington 98195 1700, USA
    Biochemistry 44:12870-8. 2005
    ..In summary, these results demonstrate that changes in local dynamics, as detected by EPR spectroscopy, can be used to study conformational changes associated with RNA folding and function...
  100. ncbi Donors of HNO
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, 85721, USA
    Curr Top Med Chem 5:649-64. 2005
    ..of nitric oxide (NO) and nitroxyl (HNO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar...
  101. ncbi N-hydroxyurea and acyl nitroso compounds as nitroxyl (HNO) and nitric oxide (NO) donors
    S Bruce King
    Department of Chemistry, Wake Forest University, Winston Salem, NC 27109, USA
    Curr Top Med Chem 5:665-73. 2005
    ..These studies present two NO releasing mechanisms from hydroxyurea that are kinetically competent with clinical observations...

Research Grants63

  1. Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..This hypothesis will be addressed by: (1) estimating prenatal exposures to nitrogen oxides (NOx) - as a marker of traffic-related air pollutants - for BIPS participants using CALINE4 air dispersion ..
  2. Redox Determinants of Severe Asthma
    Serpil C Erzurum; Fiscal Year: 2010
    ..In aim 3, we investigate formation of cytotoxic nitrogen oxides and loss of beneficial nitrogen oxides...
  3. BIOINORGANIC COPPER COORDINATION CHEMISTRY
    Kenneth D Karlin; Fiscal Year: 2013
    ..coordination chemistry relevant to its essential role in the biochemical processing of dioxygen (O2) and nitrogen oxides (NOx)...
  4. 2010 Oxygen Radicals: Mechanisms that Underpin Redox Biology - a Gordon Research
    Garry R Buettner; Fiscal Year: 2010
    ..stress;oxidative events in cardiovascular disease;biochemistry of thiol oxidation &thiol enzymes;nitrogen oxides &hydrogen sulfide;protein oxidation, redox changes &aging;mitochondria, central to redox balance;..
  5. Air Pollution and Children's Cognitive and Health Outcomes
    Ashlesha Datar; Fiscal Year: 2013
    ..exposure to criteria pollutants (particulate matter, ground-level ozone, carbon monoxide, sulfur oxides, nitrogen oxides, and lead) with adverse health outcomes in children, however, much of this literature is based on cross-..
  6. Cellular S-nitrosothiol signaling in respiratory biology
    Lisa Palmer; Fiscal Year: 2013
    ..Emerging evidence from our group and others suggests that S-nitrosothiol (and related nitrogen oxides such as nitrite)-based signaling downstream from nitric oxide synthase activation is relevant to respiratory ..
  7. Air pollution exposure and COPD in the Framingham Heart Study
    Mary B Rice; Fiscal Year: 2013
    ..that elevations in short-term exposure to air pollutants (fine particulate matter, black carbon, ozone, nitrogen oxides, sulfates and metals) will impair lung function by spirometry and DLCO after adjustment for smoking...
  8. Air Pollution and Parkinson's in the Danish PASIDA Study
    Beate R Ritz; Fiscal Year: 2013
    ..Exposure is modeled in AirGIS based on nitrogen dioxides (NO2)/nitrogen oxides (NOx) which serve as indicators for air pollution mixtures from traffic...
  9. PEROXIDASE IN SALIVA AND PREVENTION OF ORAL DISEASE
    EDWIN THOMAS; Fiscal Year: 1992
    ..The goal of the project is to achieve a greater understanding of the role of oxidizing agents in oral health and disease...
  10. Nitrogen Oxides and Heme
    GEORGE RICHTER ADDO; Fiscal Year: 2007
    Iron plays significant roles in the chemistry of nitrogen oxides in the biosphere...
  11. PYRIDINE--ENZYME INDUCTION, METABOLISM, AND TOXICITY
    Melissa Runge Morris; Fiscal Year: 1991
    ..metabolism of pyridine to an N-oxide derivative is an important biotransformation pathway in vivo, and some nitrogen oxides have implicated as carcinogens...
  12. Xanthine DNA Glycosylase in Mammalian Systems
    Weiguo Cao; Fiscal Year: 2010
    ..b>Nitrogen oxides (NOx) in the environment or RNS produced from endogenous sources can cause deamination in DNA bases...
  13. Novel Platform for NOx Reduction from Furnaces
    DONALD STOOKEY; Fiscal Year: 2004
    ..They have been the subjects of extensive regulations including the Clean Air Act. Nitrogen oxides are collectively referred to as NOx, which is the total amount of nitric oxide (NO) and nitrogen dioxide (NO2)..
  14. REGULATION OF RYANODINE RECEPTOR BY NITROGEN OXIDES
    Jerry Eu; Fiscal Year: 2003
    ..Our results may lead to new insights into regulation of Ca2+ homeostasis in muscle and to the dysregulation of Ca2+ characteristic of disease states such as respiratory failure and rhabdomyolysis. ..
  15. PROTEIN MODIFICATION BY NITRATION IN AGING RATS
    Reiko Matsui; Fiscal Year: 2001
    ..Peroxynitrite and other reactive nitrogen oxides nitrate proteins and modify their function...
  16. MODULATION OF EGF-RECEPTOR SIGNALING
    Albert van Der Vliet; Fiscal Year: 2001
    ..that exposure of epithelial cells that overexpress epidermal growth factor receptors (EGFR) to reactive nitrogen oxides causes irreversible cross-linking of this receptor tyrosine kinase, which is hypothesized to involve ..
  17. Exhaled Biomarkers During Treatment of Rhinovirus
    John Hunt; Fiscal Year: 2004
    ..identify baseline and post infection levels of exhaled inflammatory cytokines, leukotrienes, hydrogen ions, nitrogen oxides, and redox components including hydrogen peroxide and lipid oxidation products...
  18. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2004
    ..often required to induce HIF-1 in vitro; 2) hemoglobin deoxygenation is associated with the transfer of nitrogen oxides to the vascular endothelium at pO2s more relevant to intravascular pathophysiology; and 3) downstream effects ..
  19. Regulation of Myeloperoxidase Catalysis by Nitric Oxide
    HUSAM ABU SOUD; Fiscal Year: 2004
    ..NO in modulating MPO activity and function and develop a comprehensive kinetic model for the interaction of nitrogen oxides with MPO...
  20. NITRIC OXIDE IN REGULATION OF HEPATIC CYTOCHROME P450
    Edward Morgan; Fiscal Year: 2000
    ..Plasma levels of nitrogen oxides will be measured to ensure that the inhibitor indeed reduces NO production...
  21. Structural Biology of Prokaryotic NO Synthases
    C Raman; Fiscal Year: 2007
    ..the proposed research will not only generate key information regarding how bacteria generate and deal with nitrogen oxides, but also provide us with critical leads for the development of novel strategies to combat biological warfare...
  22. STUDY OF CHRONIC OBSTRUCTIVE LUNG DISEASE
    GUSTAVE FREEMAN; Fiscal Year: 1980
    The pathogenesis of chronic obstructive lung disease (emphysema) will be investigated using mainly nitrogen oxides, generated in tobacco smoke and in the atmosphere, as well as ozone and other oxidizing gases...
  23. PATHOGENESIS OF CARDIAC INJURY IN SIMIAN AIDS
    Richard Shannon; Fiscal Year: 2000
    ..development of LV contractile dysfunction with changes in both circulating and transmyocardial cytokines and nitrogen oxides; 3) Examine the role of opportunistic infections (e.g...
  24. Structure, dynamics, and function of the packaging RNA
    Peter Z Qin; Fiscal Year: 2010
    ..Understanding phi29 packaging motor function will aid in developing pharmacological approaches to combat these viruses. ..
  25. OMRF MRI SYSTEM
    ROBERT FLOYD; Fiscal Year: 2004
    ..Additionally, new MRI technology will be developed for assessing tissue localization of specific flee radicals with a focus on nitric oxide intermediates, and tissue-specific contrast enhancement. ..
  26. FREE RADICALS AND CHOLINE DEFICIENT LIVER CARCINOGENESIS
    ROBERT FLOYD; Fiscal Year: 2005
    ..C) We will determine if PBN (or its metabolite 4-OH-PBN) inhibits CD-mediated HCC development and ascertain if these compounds increase apoptosis in preneoplastic cells in this model. ..
  27. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
  28. EPR Sample-cell-Resonator Design and Construction
    James Hyde; Fiscal Year: 2008
    ..Work proposed here will improve the quality of data obtained in these experiments. [unreadable] [unreadable] [unreadable]..
  29. BROADBAND EPR SPECTROMETER WITH DIGITAL SUBSAMPLING
    James Hyde; Fiscal Year: 2003
    ..It is the only method that can detect the formation of free radicals in biology unambiguously. It contributes to health-related research at the basic fundamental level. ..
  30. Novel Spin Traps for Biological Free Radical Detection
    Frederick A Villamena; Fiscal Year: 2010
    ..The synergistic application of these technologies will provide an optimal strategy to provide new materials which can be effective in probing the role of reactive oxygen species in biological mechanisms. ..
  31. BROADBAND EPR SPECTROMETER WITH DIGITAL SUBSAMPLING
    James Hyde; Fiscal Year: 2002
    ..It is the only method that can detect the formation of free radicals in biology unambiguously. It contributes to health-related research at the basic fundamental level. ..
  32. Nitroxyl and Nitric Oxide Producing Reactions of Hydroxyurea and Related Compound
    S Bruce King; Fiscal Year: 2010
    ..The results from these studies should enhance our ability to use HNO/NO donors as treatments for sickle cell disease, other anemias and congestive heart failure. . ..
  33. SYNTHESIS OF BIOACTIVE MACROLIDES
    James White; Fiscal Year: 2002
    ..These pathways, regardless of whether they are successful, must also serve as paradigms for accessing other potentially useful chemotherapeutic agents of equal or greater complexity. ..
  34. DEVELOPMENT OF BIOMEDICAL ESR INSTRUMENTATION
    James Hyde; Fiscal Year: 2002
    ..The investigator asserts that only on such a foundation can a rational approach to improved human health be based. ..
  35. 3T Whole-Body MRI Scanner for Functional Imaging
    James Hyde; Fiscal Year: 2003
    ..It will have no clinical fee-for-service usage. The fMRI group at MCW is superbly positioned to provide leadership at a national level in the use of fMRI in medicine. ..
  36. ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUT
    RALPH DELFINO; Fiscal Year: 2001
    ..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
  37. BIOLOGICAL ACTIVITY OF N-HYDROXY-L-ARGININE
    Jon Fukuto; Fiscal Year: 2001
    ..An understanding of the mechanism of action of NHA may lead to the development of novel and unique strategies for the treatment of infection or cancer. ..
  38. LOOP GAP RESONATOR COILS FOR MRI AND 31P SPECTROSCOPY
    James Hyde; Fiscal Year: 2001
    ..The research proposed here is in support of these four streams of fMRI research. ..
  39. Assessment of the Chemical Biology of HNO via New Donors
    Katrina M Miranda; Fiscal Year: 2010
    ..goal is to utilize this diversity in conjunction with a thorough understanding of the chemical biology of nitrogen oxides to provide disease treatments...
  40. SYNTHESIS OF BIOACTIVE ALKALOIDS
    James White; Fiscal Year: 2006
    ..A plan is presented for the synthesis of this complex heptacyclic molecule which envisions a thio-Claisen rearrangement as the key step for building the vicinal quaternary carbons of this structure. ..
  41. Depletion of Mitochondrial S-Nitrosothiols in ALS
    Joan Mannick; Fiscal Year: 2005
    ..Our long term goal is to determine if SNO donor compounds (which have been used for decades in the treatment of coronary artery disease with limited toxicity) have therapeutic efficacy in patients with ALS. ..
  42. Azulenyl nitrones: neuroprotectants in stroke and trauma
    MYRON GINSBERG; Fiscal Year: 2006
    ..Two world-renowned authorities in oxygen-radical biochemistry and vascular pharmacology drawn from both academia and the pharmaceutical industry will serve as External Advisors to guide us throughout this project. ..
  43. ADULT AIDS CLINICAL TRIALS UNIT
    David Clifford; Fiscal Year: 2006
    ..abstract_text> ..
  44. Socioeconomic Status, Stress, Air Pollution and Asthma
    Rob McConnell; Fiscal Year: 2006
    ....
  45. ENOS & THE RADICAL MECHANISM OF ANTITUMOR ANTHRACYCLINES
    Balaraman Kalyanaraman; Fiscal Year: 2006
    ..Understanding the relationship between DOX-induced apoptosis and ROS formation may help discover novel antioxidant/antiapoptotic therapy in oxidant-induced disease processes. ..
  46. A NON-HUMAN PRIMATE MODEL OF TUBERCULOSIS AND AIDS
    Joanne Flynn; Fiscal Year: 2004
    ..Once a non-human primate model for tuberculosis is established, it could be used to test vaccines, immunotherapy, and new treatment options for tuberculosis. ..
  47. Abdominal Aortic Aneurysm
    M Tilson; Fiscal Year: 2005
    ..Recent approaches such as the search for candidate genes and the methodology of genome wide scanning among AAA families or sibling pairs will be discussed. ..
  48. MACROPHAGES, DENDRITIC CELLS AND PATHOGENS
    Carl Nathan; Fiscal Year: 2007
    ..Cores provide for BSL3 wet lab and mouse work; microarray analysis of gene expression; computation and comparison of gene expression results; and high throughput screening of chemical libraries. ..
  49. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  50. Monitoring Oxygen Repeatedly for Hypoxic Tumor Therapy
    Mohammad Khan; Fiscal Year: 2007
    ..If successful, this approach potentially could be immediately extended for clinical applications. [unreadable] [unreadable] [unreadable]..
  51. Antioxidant Interaction of Selenium and Vitamins C & E
    James May; Fiscal Year: 2008
    ..Using this approach, it will be possible to relate the crucial, mitochondrial functions of selenium and vitamins C and E to the antioxidant defenses of the whole animal. ..
  52. Regulation of Oxidative Stress in the mdx Diaphragm
    JOHN LAWLER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  53. Immune Responsiveness, APOE/Gender in Neurodegeneration
    Carol Colton; Fiscal Year: 2008
    ..Thus, we will examine the role of hormones in the regulation of microglial and peritoneal macrophage immune activation in mice expressing only human apoE3 protein or expressing only human apoE4 protein. ..
  54. Center for Childhood Asthma in the Urban Environment
    Patrick Breysse; Fiscal Year: 2008
    ..abstract_text> ..
  55. Theory of the Chemistry of NO, HNO, OONO-, and RSNO
    KENDALL HOUK; Fiscal Year: 2009
    ..This project has used the tools of computational quantum mechanisms to explore the mechanistic chemistry of nitrogen oxides and derivatives, especially NO, HNO, and RSNO...
  56. Lipid nanotube arrays for membrane protein biochips
    Alex Smirnov; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  57. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
    ..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
  58. PROTEIN STRUCTURE BY ANALYSIS OF SPIN LABEL INTERACTIONS
    ERIC HUSTEDT; Fiscal Year: 2003
    ..abstract_text> ..
  59. MASS SPECTROMETRIC IDENTIFICATION OF NEW LIPID MEDIATORS
    Michael Balazy; Fiscal Year: 2005
    ....