hydrogen sulfide

Summary

Summary: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)

Top Publications

  1. pmc The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener
    W Zhao
    Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada
    EMBO J 20:6008-16. 2001
  2. pmc Hydrogen sulfide is a signaling molecule and a cytoprotectant
    Hideo Kimura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 17:45-57. 2012
  3. pmc H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase
    Guangdong Yang
    Department of Physiology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
    Science 322:587-90. 2008
  4. pmc Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice
    John W Calvert
    Department of Surgery, Emory University School of Medicine, Atlanta, GA 30308, USA
    Circulation 122:11-9. 2010
  5. ncbi Hydrogen sulfide-releasing anti-inflammatory drugs
    John L Wallace
    Inflammation Research Network, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Trends Pharmacol Sci 28:501-5. 2007
  6. ncbi Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?
    Rui Wang
    Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5
    FASEB J 16:1792-8. 2002
  7. doi Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria
    Yuka Kimura
    Department of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 12:1-13. 2010
  8. doi Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide
    Norihiro Shibuya
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biochem 146:623-6. 2009
  9. ncbi Hydrogen sulfide protects neurons from oxidative stress
    Yuka Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    FASEB J 18:1165-7. 2004
  10. doi Hydrogen sulfide and cell signaling
    Ling Li
    Imperial College London, United Kingdom
    Annu Rev Pharmacol Toxicol 51:169-87. 2011

Research Grants

Detail Information

Publications413 found, 100 shown here

  1. pmc The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener
    W Zhao
    Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada
    EMBO J 20:6008-16. 2001
    b>Hydrogen sulfide (H(2)S) has been traditionally viewed as a toxic gas. It is also, however, endogenously generated from cysteine metabolism...
  2. pmc Hydrogen sulfide is a signaling molecule and a cytoprotectant
    Hideo Kimura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 17:45-57. 2012
    Accumulating evidence shows that hydrogen sulfide may function as a signaling molecule in processes such as neuromodulation in the brain and smooth muscle relaxation in the vascular system...
  3. pmc H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase
    Guangdong Yang
    Department of Physiology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
    Science 322:587-90. 2008
    ..The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention...
  4. pmc Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice
    John W Calvert
    Department of Surgery, Emory University School of Medicine, Atlanta, GA 30308, USA
    Circulation 122:11-9. 2010
    b>Hydrogen sulfide (H(2)S) is an endogenous signaling molecule with potent cytoprotective effects. The present study evaluated the therapeutic potential of H(2)S in murine models of heart failure.
  5. ncbi Hydrogen sulfide-releasing anti-inflammatory drugs
    John L Wallace
    Inflammation Research Network, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Trends Pharmacol Sci 28:501-5. 2007
    ..In recent years, physiological roles of hydrogen sulfide (H2S) have been recognized, and there is emerging evidence that this endogenous gaseous substance can ..
  6. ncbi Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?
    Rui Wang
    Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5
    FASEB J 16:1792-8. 2002
    Bearing the public image of a deadly "gas of rotten eggs," hydrogen sulfide (H2S) can be generated in many types of mammalian cells...
  7. doi Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria
    Yuka Kimura
    Department of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 12:1-13. 2010
    b>Hydrogen sulfide (H(2)S) is a synaptic modulator as well as a neuroprotectant in the brain...
  8. doi Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide
    Norihiro Shibuya
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biochem 146:623-6. 2009
    b>Hydrogen sulfide (H(2)S) has been recognized as a smooth muscle relaxant. Cystathionine gamma-lyase, which is localized to smooth muscle, is thought to be the major H(2)S-producing enzyme in the thoracic aorta...
  9. ncbi Hydrogen sulfide protects neurons from oxidative stress
    Yuka Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    FASEB J 18:1165-7. 2004
    b>Hydrogen sulfide (H2S), which is a well-known toxic gas, is found in relatively high concentrations in the brain. Although a neuromodulatory role of H2S has been demonstrated, little is known of its other biological functions...
  10. doi Hydrogen sulfide and cell signaling
    Ling Li
    Imperial College London, United Kingdom
    Annu Rev Pharmacol Toxicol 51:169-87. 2011
    b>Hydrogen sulfide (H₂S) is a gaseous mediator synthesized from cysteine by cystathionine γ lyase (CSE) and other naturally occurring enzymes...
  11. pmc Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function
    Kunihiro Suzuki
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 108:13829-34. 2011
    The goal of the present studies was to investigate the role of changes in hydrogen sulfide (H(2)S) homeostasis in the pathogenesis of hyperglycemic endothelial dysfunction...
  12. doi Roles of hydrogen sulfide and nitric oxide in the alleviation of cadmium-induced oxidative damage in alfalfa seedling roots
    Le Li
    College of Life Sciences, Cooperative Demonstration Laboratory of Centrifuge Technique of Nanjing Agricultural University and Beckman Coulter Ltd Co, Nanjing 210095, People s Republic of China
    Biometals 25:617-31. 2012
    Despite hydrogen sulfide (H(2)S) and nitric oxide (NO) are important endogenous signals or bioregulators involved in many vital aspects of plant growth and responses against abiotic stresses, little information was known about their ..
  13. ncbi Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes
    Jin Song Bian
    Cardiovascular Biology Research Group, Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore
    J Pharmacol Exp Ther 316:670-8. 2006
    ..Our findings suggest that endogenous H(2)S contributes to cardioprotection induced by IP, which effect may involve protein kinase C and sarcolemmal K(ATP) channels...
  14. doi Hydrogen sulfide: its production, release and functions
    Hideo Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Amino Acids 41:113-21. 2011
    b>Hydrogen sulfide (H(2)S), which is a well-known toxic gas, has been recognized as a signal molecule as well as a cytoprotectant...
  15. ncbi The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?
    Matthew Whiteman
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, Republic of Singapore
    J Neurochem 90:765-8. 2004
    b>Hydrogen sulfide (H2S) is a well-known cytotoxic gas. Recently it has been shown to stimulate N-methyl-D-aspartate (NMDA) receptors to enhance long-term potentiation suggesting a novel neuromodulatory role in vivo...
  16. doi 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain
    Norihiro Shibuya
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Kiyose, Tokyo, Japan
    Antioxid Redox Signal 11:703-14. 2009
    b>Hydrogen sulfide (H(2)S) is a synaptic modulator as well as a neuroprotectant. Currently, pyridoxal-5'-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) is thought to be the major H(2)S-producing enzyme in the brain...
  17. pmc Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15560-5. 2007
    The recent discovery that hydrogen sulfide (H(2)S) is an endogenously produced gaseous second messenger capable of modulating many physiological processes, much like nitric oxide, prompted us to investigate the potential of H(2)S as a ..
  18. pmc Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions
    Nilkantha Sen
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 45:13-24. 2012
    ..We show that the antiapoptotic actions of NF-κB are mediated by hydrogen sulfide (H(2)S) synthesized by cystathionine gamma-lyase (CSE)...
  19. doi Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models
    Li Fang Hu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Aging Cell 9:135-46. 2010
    ..The present study was designed to examine the therapeutic effect of hydrogen sulfide (H(2)S, a novel biological gas) on PD...
  20. pmc Hydrogen sulfide mediates cardioprotection through Nrf2 signaling
    John W Calvert
    Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, 550 Peachtree St NE, Atlanta, GA 30308, USA
    Circ Res 105:365-74. 2009
    The recent emergence of hydrogen sulfide (H(2)S) as a potent cardioprotective signaling molecule necessitates the elucidation of its cytoprotective mechanisms.
  21. pmc Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells
    Aiping Lan
    Department of Physiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, People s Republic of China
    PLoS ONE 6:e25921. 2011
    b>Hydrogen sulfide (H(2)S) has been proposed as a novel neuromodulator and neuroprotective agent. Cobalt chloride (CoCl(2)) is a well-known hypoxia mimetic agent...
  22. doi Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide
    Ling Li
    Department of Pharmacology, National University of Singapore, Singapore
    Circulation 117:2351-60. 2008
    The potential biological significance of hydrogen sulfide (H(2)S) has attracted growing interest in recent years...
  23. doi Physiological implications of hydrogen sulfide: a whiff exploration that blossomed
    Rui Wang
    Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada
    Physiol Rev 92:791-896. 2012
    The important life-supporting role of hydrogen sulfide (H(2)S) has evolved from bacteria to plants, invertebrates, vertebrates, and finally to mammals...
  24. ncbi H(2)S-induced vasorelaxation and underlying cellular and molecular mechanisms
    Weimin Zhao
    Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5
    Am J Physiol Heart Circ Physiol 283:H474-80. 2002
    ..Our results demonstrate that the vascular effect of H(2)S is partially mediated by a functional endothelium and dependent on the extracellular calcium entry but independent of the activation of the cGMP pathway...
  25. ncbi Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats
    Youqin Cheng
    Dept of Physiology, College of Medicine, Univ of Saskatchewan, 107 Wiggins Rd, Saskatoon, Saskatchewan, Canada S7N 5E5
    Am J Physiol Heart Circ Physiol 287:H2316-23. 2004
    b>Hydrogen sulfide (H2S) has been shown recently to function as an important gasotransmitter...
  26. ncbi Endogenous production of hydrogen sulfide in mammals
    P Kamoun
    Laboratoire de Biochimie MéDdicale B, Hopital Necker Enfants Malades, Paris, France
    Amino Acids 26:243-54. 2004
    b>Hydrogen sulfide is one of three gases involved in biological functions and synthesized in vivo. Like NO and CO, it seems to act as a neuromodulator: it modulates NMDA glutamate receptor function...
  27. pmc Hydrogen sulfide induces systemic tolerance to salinity and non-ionic osmotic stress in strawberry plants through modification of reactive species biosynthesis and transcriptional regulation of multiple defence pathways
    Anastasis Christou
    Department of Environmental Science and Technology, Cyprus University of Technology, 3603 Lemesos, Cyprus
    J Exp Bot 64:1953-66. 2013
    b>Hydrogen sulfide (H2S) has been recently found to act as a potent priming agent. This study explored the hypothesis that hydroponic pretreatment of strawberry (Fragaria × ananassa cv...
  28. pmc TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide
    David A Andersson
    Wolfson Centre for Age Related Diseases, King s College London, London, United Kingdom
    PLoS ONE 7:e46917. 2012
    b>Hydrogen sulfide (H(2)S), which is produced endogenously from L-cysteine, is an irritant with pro-nociceptive actions...
  29. doi Hydrogen sulfide: environmental factor or signalling molecule?
    Miroslav Lisjak
    Department of Agroecology, University of J J Strossmayer, Osijek 31000, Croatia
    Plant Cell Environ 36:1607-16. 2013
    b>Hydrogen sulfide (H₂S) has traditionally been thought of as a phytotoxin, having deleterious effects on the plant growth and survival...
  30. ncbi Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1
    Guangdong Yang
    Department of Physiology, College of Medicine, The Cardiovascular Research Group, Saskatoon, Sastatchewan, Canada
    J Biol Chem 279:49199-205. 2004
    ..CSE uses L-cysteine as a substrate to produce hydrogen sulfide (H2S)...
  31. pmc Inhaled hydrogen sulfide prevents endotoxin-induced systemic inflammation and improves survival by altering sulfide metabolism in mice
    Kentaro Tokuda
    Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine at the Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Antioxid Redox Signal 17:11-21. 2012
    The role of hydrogen sulfide (H(2)S) in endotoxin (lipopolysaccharide [LPS])-induced inflammation is incompletely understood...
  32. pmc Effects of hydrogen sulfide-releasing L-DOPA derivatives on glial activation: potential for treating Parkinson disease
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 285:17318-28. 2010
    ..Here we demonstrate the properties of four such L-DOPA hybrids based on coupling L-DOPA to four different hydrogen sulfide-donating compounds...
  33. pmc Hydrogen sulfide is an endogenous stimulator of angiogenesis
    Andreas Papapetropoulos
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras 265 04 Rio Patras, Patras, Greece
    Proc Natl Acad Sci U S A 106:21972-7. 2009
    The goal of the current study was to investigate the role of exogenous and endogenous hydrogen sulfide (H(2)S) on neovascularization and wound healing in vitro and in vivo...
  34. pmc The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide
    Mark W Budde
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington 98195, USA
    Genetics 189:521-32. 2011
    b>Hydrogen sulfide (H2S), an endogenously produced small molecule, protects animals from various stresses...
  35. ncbi Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation
    Renata C O Zanardo
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    FASEB J 20:2118-20. 2006
    b>Hydrogen sulfide (H2S) is increasingly recognized as an important signaling molecule in the cardiovascular and nervous systems...
  36. pmc Hydrogen sulfide mitigates transition from compensatory hypertrophy to heart failure
    Srikanth Givvimani
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky, USA
    J Appl Physiol (1985) 110:1093-100. 2011
    ..Previous studies have shown the cardioprotective role of hydrogen sulfide (H₂S) in various cardiac diseases, but its role during transition from compensatory hypertrophy to heart ..
  37. doi Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential
    Madhav Lavu
    Department of Surgery, The Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA 30308, USA
    Clin Sci (Lond) 120:219-29. 2011
    H2S (hydrogen sulfide), viewed with dread for more than 300 years, is rapidly becoming a ubiquitously present and physiologically relevant signalling molecule...
  38. pmc Hydrogen sulfide protects the retina from light-induced degeneration by the modulation of Ca2+ influx
    Yoshinori Mikami
    Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biol Chem 286:39379-86. 2011
    b>Hydrogen sulfide (H(2)S) has recently been recognized as a signaling molecule as well as a cytoprotectant. Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are well-known as H(2)S-producing enzymes...
  39. doi Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract
    Gary R Martin
    Inflammation Research Network, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dig Liver Dis 42:103-9. 2010
    ..Little is known about H2S synthesis in the gastrointestinal tract. The aim of this study was to characterize H2S synthesis throughout the gastrointestinal tract...
  40. doi Hydrogen sulfide protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by preventing GSK-3beta-dependent opening of mPTP
    Ling Ling Yao
    Dept of Physiology and Pathophysiology, Fudan University Shanghai Medical College, 138 Yi Xue Yuan Rd, Shanghai, China
    Am J Physiol Heart Circ Physiol 298:H1310-9. 2010
    b>Hydrogen sulfide (H(2)S) is an endogenously generated gaseous transmitter, which has recently been suggested to regulate cardiovascular functions...
  41. pmc Signaling by gasotransmitters
    Asif K Mustafa
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Sci Signal 2:re2. 2009
    ..Evidence is accumulating that carbon monoxide and hydrogen sulfide also are physiologic mediators in the cardiovascular, immune, and nervous systems...
  42. ncbi Hydrogen sulfide enhances ulcer healing in rats
    John L Wallace
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    FASEB J 21:4070-6. 2007
    b>Hydrogen sulfide is an endogenous mediator that relaxes vascular smooth muscle, exhibits several antiinflammatory activities, and contributes to gastric mucosal defense...
  43. ncbi Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol
    Bin Geng
    Department of Physiology, Peking University Health Science Center, PR China
    Biochem Biophys Res Commun 318:756-63. 2004
    Previous work has shown that the endogenous cystathionine gamma-synthase (CSE)/hydrogen sulfide (H(2)S) pathway participates in the regulation of cardiac contraction...
  44. doi Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice
    Yanfei Wang
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, West District, Beijing 100034, PR China
    Arterioscler Thromb Vasc Biol 29:173-9. 2009
    We explored the effect of hydrogen sulfide (H(2)S) on atherosclerotic progression, particularly on intracellular adhesion molecule-1 (ICAM-1) in apolipoprotein-E knockout (apoE(-/-)) mice and human umbilical vein endothelial cells (HUVECs)...
  45. doi GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat
    Ling Li
    Pharmaceutical Science Research Division, King s College, University of London, London, UK
    Free Radic Biol Med 47:103-13. 2009
    GYY4137 (morpholin-4-ium-4-methoxyphenyl(morpholino) phosphinodithioate) is a slow-releasing hydrogen sulfide (H(2)S) donor...
  46. ncbi Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels
    Eleonora Distrutti
    University of Perugia, Clinica di Gastroenterologia, Policlinico Monteluce, Via Enrico Dal Pozzo, 06122 Perugia, Italy
    J Pharmacol Exp Ther 316:325-35. 2006
    b>Hydrogen sulfide (H(2)S) functions as a neuromodulator, but whether it modulates visceral perception and pain is unknown...
  47. ncbi Hydrogen sulfide protects HT22 neuronal cells from oxidative stress
    Yuka Kimura
    National Institute of Neuroscience, Tokyo, Japan
    Antioxid Redox Signal 8:661-70. 2006
    b>Hydrogen sulfide (H2S) is a neuromodulator in the brain and a relaxant for smooth muscle...
  48. ncbi Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3
    Guangdong Yang
    Department of Physiology, College of Medicine, Cardiovascular Research Group, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    FASEB J 18:1782-4. 2004
    The endogenous production of hydrogen sulfide (H2S) and its physiological functions, including membrane hyperpolarization and smooth muscle cell relaxation, position this gas well in the family of gasotransmitters together with nitric ..
  49. ncbi Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide
    Gi Su Oh
    Department of Microbiology and Immunology and Medicinal Resources Research Institute, Wonkwang University School of Medicine, Iksan, Chonbuk 570 749, Republic of Korea
    Free Radic Biol Med 41:106-19. 2006
    b>Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its ..
  50. ncbi Hydrogen sulfide (H2S) - the third gas of interest for pharmacologists
    Ewelina Łowicka
    Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 59:4-24. 2007
    ..Recent studies suggest that hydrogen sulfide (H(2)S) is the third gaseous mediator in mammals...
  51. ncbi Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia
    Li Fang Hu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Neurochem 100:1121-8. 2007
    ..These findings may have important implications in the treatment of neuroinflammation-related diseases...
  52. pmc Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury
    Roland C Francis
    Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 115:1012-21. 2011
    The antiinflammatory effects of hydrogen sulfide (H2S) and sodium sulfide (Na2S) treatment may prevent acute lung injury induced by high tidal volume (HVT) ventilation...
  53. pmc Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury
    John L Wallace
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Antioxid Redox Signal 17:58-67. 2012
    b>Hydrogen sulfide is emerging as an important mediator of many aspects of inflammation, and perhaps most importantly as a factor promoting the resolution of inflammation and repair of injury.
  54. doi Hydrogen sulfide improves drought resistance in Arabidopsis thaliana
    Zhuping Jin
    School of Life Science, Shanxi University, Taiyuan 030006, China
    Biochem Biophys Res Commun 414:481-6. 2011
    b>Hydrogen sulfide (H(2)S) plays a crucial role in human and animal physiology. Its ubiquity and versatile properties have recently caught the attention of plant physiologists and biochemists...
  55. pmc Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
    Csaba Szabo
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 110:12474-9. 2013
    The physiological functions of hydrogen sulfide (H2S) include vasorelaxation, stimulation of cellular bioenergetics, and promotion of angiogenesis...
  56. pmc Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research
    Richard S Beard
    Department of Biological Sciences, Idaho State University, Pocatello, Idaho ID 83209 8007, USA
    Am J Physiol Heart Circ Physiol 300:H13-26. 2011
    Homocysteine (Hcy), a cardiovascular and neurovascular disease risk factor, is converted to hydrogen sulfide (H(2)S) through the transsulfuration pathway...
  57. doi Hydrogen sulfide attenuates hyperhomocysteinemia-induced cardiomyocytic endoplasmic reticulum stress in rats
    Hongling Wei
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, West District, Beijing, P R China
    Antioxid Redox Signal 12:1079-91. 2010
    The mechanisms responsible for the cardioprotective effect of hydrogen sulfide (H(2)S) are unclear...
  58. pmc Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection
    Xianli Wang
    Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, People s Republic of China
    Biosci Rep 31:87-98. 2011
    ..Recent studies have shown that hydrogen sulfide (H2S) has cardioprotective effects...
  59. doi Hydrogen sulfide promotes root organogenesis in Ipomoea batatas, Salix matsudana and Glycine max
    Hua Zhang
    School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China
    J Integr Plant Biol 51:1086-94. 2009
    In this report, we demonstrate that sodium hydrosulfide (NaHS), a hydrogen sulfide (H(2)S) donor, promoted adventitious root formation mediated by auxin and nitric oxide (NO)...
  60. doi Hydrogen sulfide protects rat lung from ischemia-reperfusion injury
    Zhifang Fu
    Department of Geriatrics, Peking University First Hospital, Xishiku Street No 8, West District, Beijing, 100034, Beijing, People s Republic of China
    Life Sci 82:1196-202. 2008
    Recent studies have indicated that hydrogen sulfide (H(2)S) is capable of modulating many physiological processes, which prompted us to investigate the potential of H(2)S as a lung protective agent...
  61. pmc Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury
    Hamid Aslami
    Laboratory of Experimental Intensive Care and Anesthesiology L E I C A, Academic Medical Center, Amsterdam, The Netherlands
    Intensive Care Med 36:1946-52. 2010
    ..A suspended-animation-like state induced by hydrogen sulfide (H₂S) protects against hypoxia-induced organ injury...
  62. doi Hydrogen sulfide protects against vascular remodeling from endothelial damage
    Thomas P Vacek
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Amino Acids 39:1161-9. 2010
    ..Because of the potent anti-oxidant, vasorelaxing, anti-hypertensive agent, hydrogen sulfide (H2S) was used to mitigate the vascular remodeling due to the differential expression of MMP and TIMP...
  63. pmc Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway
    Takayuki Morikawa
    Department of Biochemistry, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 109:1293-8. 2012
    ..Thus, in intact adult brain cerebral cortex of HO-2-null mice, imaging mass spectrometry reveals an impaired ability to maintain ATP levels on hypoxia...
  64. ncbi Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor
    H Kimura
    Salk Institute for Biological Studies, San Diego, California, 92138, USA
    Biochem Biophys Res Commun 267:129-33. 2000
    b>Hydrogen sulfide (H(2)S) is produced endogenously from l-cysteine in mammalian tissues, and may function as a neuromodulator in the brain as well as a tone regulator in smooth muscle...
  65. ncbi Hydrogen sulfide as a neuromodulator
    Hideo Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Mol Neurobiol 26:13-9. 2002
    b>Hydrogen sulfide (H2S) is a well-known toxic gas with the smell of rotten eggs. Since the first description of the toxicity of H2S in 1713, most studies about H2S have been devoted to its toxic effects...
  66. doi Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats
    Wei Li
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Atherosclerosis 215:323-30. 2011
    This study was designed to examine the effect of sulfur dioxide (SO(2)) on atherosclerotic progression and endogenous vascular hydrogen sulfide (H(2)S) in rats with atherosclerosis (AS).
  67. pmc Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells
    Ya C Wu
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    PLoS ONE 7:e37572. 2012
    b>Hydrogen sulfide (H(2)S) is a gaseous bacterial metabolite that reaches high levels in the large intestine. In the present study, the effect of H(2)S on the proliferation of normal and cancerous colon epithelial cells was investigated...
  68. doi Treatment with exogenous hydrogen sulfide attenuates hyperoxia-induced acute lung injury in mice
    Huai Dong Li
    Department of Respiratory Disease, The Chinese PLA General Hospital, Beijing 100853, China
    Eur J Appl Physiol 113:1555-63. 2013
    The aim of this work was to test the effect of treatment with hydrogen sulfide (H2S) on hyperoxia-induced acute lung injury in mice. Mice were exposed to room air or 95 % O2, and treated with NaHS (intraperitoneal injection of 0...
  69. pmc Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells
    Mark M Perry
    Experimental Studies, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Am J Respir Cell Mol Biol 45:746-52. 2011
    b>Hydrogen sulfide (H(2)S) is synthesized intracellularly by the enzymes cystathionine-γ-lyase and cystathionine-β-synthase (CBS), and is proposed to be a gasotransmitter with effects in modulating inflammation and cellular proliferation...
  70. doi Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising
    Matthew Whiteman
    Peninsula Medical School, University of Exeter, St Luke s Campus, Magdalen Road, Exeter, Devon, EX1 2LU, UK
    Expert Rev Clin Pharmacol 4:13-32. 2011
    b>Hydrogen sulfide is rapidly gaining ground as a physiological mediator of inflammation, but there is no clear consensus as to its precise role in inflammatory signaling...
  71. pmc Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation
    Charles W Leffler
    Dept of Physiology, University of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    J Appl Physiol (1985) 100:1065-76. 2006
    ..Both the HO-CO and CSE-H2S systems have potential to interact with NO and prostanoids in the cerebral circulation. Much of the physiology and biochemistry of HO-CO and CSE-H2S in the cerebral circulation remains open for exploration...
  72. doi Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools
    Matthew Whiteman
    Peninsula Medical School, University of Exeter, St Luke s Campus, Magdalen Road, Exeter EX1 2LU, UK
    Clin Sci (Lond) 121:459-88. 2011
    H2S (hydrogen sulfide) is a well known and pungent gas recently discovered to be synthesized enzymatically in mammalian and human tissues...
  73. doi Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effect
    Mitali Chattopadhyay
    Department of Physiology and Pharmacology, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY 10031, United States
    Biochem Pharmacol 83:715-22. 2012
    b>Hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs (HS-NSAIDs) are an emerging novel class of compounds with significant anti-inflammatory properties...
  74. pmc No facilitator required for membrane transport of hydrogen sulfide
    John C Mathai
    Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 106:16633-8. 2009
    b>Hydrogen sulfide (H(2)S) has emerged as a new and important member in the group of gaseous signaling molecules. However, the molecular transport mechanism has not yet been identified...
  75. pmc Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway
    Chuntao Yang
    Department of Physiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 6:e21971. 2011
    b>Hydrogen sulfide (H(2)S) has been shown to protect against oxidative stress injury and inflammation in various hypoxia-induced insult models...
  76. doi Electro-acupuncture protects against hypoxic-ischemic brain-damaged immature rat via hydrogen sulfide as a possible mediator
    Ying Liu
    Department of Pediatrics, Chinese PLA General Hospital, 28, FuXing Road, Beijing, China
    Neurosci Lett 485:74-8. 2010
    We investigated whether hydrogen sulfide (H(2)S) may be a mediator of electro-acupuncture (EA) stimulation treatment for hypoxic-ischemic brain-damage (HIBD)...
  77. doi Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels
    Yumi Maeda
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Pain 142:127-32. 2009
    b>Hydrogen sulfide (H2S), a gasotransmitter, facilitates membrane currents through T-type Ca2+ channels, and intraplantar (i.pl.) administration of NaHS, a donor of H2S, causes prompt hyperalgesia in rats...
  78. ncbi Hydrogen sulfide generation in mammals: the molecular biology of cystathionine-β- synthase (CBS) and cystathionine-γ-lyase (CSE)
    Barbara Renga
    Department of Experimental and Clinical Medicine, Street E, dal Pozzo, Pad W, University of Perugia, Perugia, Italy
    Inflamm Allergy Drug Targets 10:85-91. 2011
    ....
  79. ncbi Hydrogen sulfide: a new gaseous signal molecule and blood pressure regulator
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Nephrol 22:173-6. 2009
    The gas hydrogen sulfide (H2S) is emerging as a novel regulator of important physiologic functions such as arterial diameter, blood flow and leukocyte adhesion. In addition, it may have antiinflammatory and antiapoptotic effects...
  80. ncbi Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse
    Ling Li
    Department of Pharmacology, National University of Singapore, Singapore
    FASEB J 19:1196-8. 2005
    b>Hydrogen sulfide (H2S) is synthesized in the body from L-cysteine by several enzymes including cystathionine-gamma-lyase (CSE). To date, there is little information about the potential role of H2S in inflammation...
  81. doi Hydrogen sulfide protects astrocytes against H(2)O(2)-induced neural injury via enhancing glutamate uptake
    Ming Lu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Free Radic Biol Med 45:1705-13. 2008
    ..The present study was designed to study the effect of hydrogen sulfide (H(2)S), a novel neuromodulator, on hydrogen peroxide (H(2)O(2)) -induced glutamate uptake impairment and ..
  82. ncbi The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver
    Stefano Fiorucci
    Dipartimenti di Medicina Clinica and Patologia, University of Perugia, Perugia, Italy
    Gastroenterology 131:259-71. 2006
    b>Hydrogen sulfide, like nitric oxide, was best known as a toxic pollutant before becoming recognized as a key regulator of several physiologic processes...
  83. doi Protective effects of cysteine analogues on acute myocardial ischemia: novel modulators of endogenous H(2)S production
    Qian Wang
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China
    Antioxid Redox Signal 12:1155-65. 2010
    ....
  84. doi Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus
    Ingeborg Dhaese
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Eur J Pharmacol 606:180-6. 2009
    The relaxant effect of hydrogen sulfide (H(2)S) in the vascular tree is well established but its influence and mechanism of action in gastrointestinal smooth muscle was hardly investigated...
  85. doi Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells
    Saima Muzaffar
    Bristol Heart Institute, University of Bristol, Bristol, UK
    J Vasc Res 45:521-8. 2008
    The activity of NADPH oxidase (NOX) is blocked by nitric oxide (NO). Hydrogen sulfide (H(2)S) is also produced by blood vessels. It is reasonable to suggest that H(2)S may have similar actions to NO on NOX...
  86. pmc Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production
    Ming Fu
    Department of Biology and School of Kinesiology, Lakehead University, Thunder Bay, ON, Canada P7B 5E1
    Proc Natl Acad Sci U S A 109:2943-8. 2012
    Although many types of ancient bacteria and archea rely on hydrogen sulfide (H(2)S) for their energy production, eukaryotes generate ATP in an oxygen-dependent fashion...
  87. doi Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats
    John L Wallace
    Inflammation Research Network, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 137:569-78, 578.e1. 2009
    b>Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator of mucosal defense with antiinflammatory effects that promote ulcer healing. The effects of H(2)S during the pathogenesis of colitis have not been established...
  88. doi The therapeutic potential of hydrogen sulfide: separating hype from hope
    Kenneth R Olson
    Indiana University School of Medicine South Bend, South Bend, Indiana 46617, USA
    Am J Physiol Regul Integr Comp Physiol 301:R297-312. 2011
    b>Hydrogen sulfide (H(2)S) has become the hot new signaling molecule that seemingly affects all organ systems and biological processes in which it has been investigated...
  89. pmc Hydrogen sulfide as a gasotransmitter
    Moataz M Gadalla
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2105, USA
    J Neurochem 113:14-26. 2010
    ..b>Hydrogen sulfide (H(2)S) is even more chemically reactive, but until recently there was little definitive evidence for its ..
  90. pmc Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries
    Qing H Meng
    Department of Pathology and Laboratory Medicine, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SK, Canada S7N 0W8
    Am J Pathol 170:1406-14. 2007
    Endogenous hydrogen sulfide (H(2)S), generated from homocysteine metabolism mainly catalyzed by cystathionine gamma-lyase (CSE), possesses important functions in the cardiovascular system...
  91. pmc Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville, KY 40202, USA
    Am J Physiol Cell Physiol 300:C155-63. 2011
    ..MCP-1) and macrophage inflammatory protein-2 (MIP-2) induction and determined the regulatory role of hydrogen sulfide (H₂S) to ameliorate inflammation...
  92. doi Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide
    Yoshinori Mikami
    Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawa Higashi, Kodaira, Tokyo, Japan
    Biochem J 439:479-85. 2011
    H2S (hydrogen sulfide) has recently been recognized as a signalling molecule as well as a cytoprotectant. We recently demonstrated that 3MST (3-mercaptopyruvate sulfurtransferase) produces H2S from 3MP (3-mercaptopyruvate)...
  93. pmc Redox biochemistry of hydrogen sulfide
    Omer Kabil
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:21903-7. 2010
    ..This report focuses on the biochemistry of H(2)S biogenesis and clearance, on the molecular mechanisms of its action, and on its varied biological effects...
  94. pmc Hydrogen sulfide increases hypoxia-inducible factor-1 activity independently of von Hippel-Lindau tumor suppressor-1 in C. elegans
    Mark W Budde
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Mol Biol Cell 21:212-7. 2010
    ..In nature, low oxygen environments are often found to contain high levels of hydrogen sulfide (H(2)S)...
  95. doi Therapeutic applications of the gaseous mediators carbon monoxide and hydrogen sulfide
    Gerard L Bannenberg
    Campus de la Universidad Autonoma, Centro Nacional de Biotecnologia CSIC, Department of Plant Molecular Genetics, Madrid, Spain
    Expert Opin Ther Pat 19:663-82. 2009
    b>Hydrogen sulfide (H(2)S) and carbon monoxide (CO) are endogenously produced gaseous autacoids that regulate a number of physiological processes, including the inflammatory response, cell death and proliferation, neural transmission and ..
  96. ncbi H2S generated by heart in rat and its effects on cardiac function
    Bin Geng
    Institute of Cardiovascular Research, Peking University First Hospital, PR China
    Biochem Biophys Res Commun 313:362-8. 2004
    b>Hydrogen sulfide (H2S), which was considered as a novel gasotransmitter, is produced endogenously from L-cysteine in mammalian brain and vessels, and might be a physiological function regulator to these organs...
  97. doi Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function
    Li Fang Hu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Mol Pharmacol 75:27-34. 2009
    b>Hydrogen sulfide (H(2)S) has been proposed as a novel neuromodulator, which plays critical roles in the central nervous system affecting both neurons and glial cells. However, its relationship with neurodegenerative diseases is unexplored...
  98. doi Toxic hydrogen sulphide and dark caves: pronounced male life-history divergence among locally adapted Poecilia mexicana (Poeciliidae)
    R Riesch
    Department of Zoology, University of Oklahoma, Norman, OK, USA
    J Evol Biol 24:596-606. 2011
    ..Together with the results from previous studies, this is strong evidence for local adaptation as a result of ecologically based divergent selection...
  99. ncbi The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells
    Junbao Du
    Department of Pediatrics, Peking University, First Hospital, Xi An Men Str No 1, West District, 100034, Beijing, PR China
    Heart Vessels 19:75-80. 2004
    b>Hydrogen sulfide (H(2)S) was recently suggested to be a possible endogenous gasotransmitter in physiological concentration...
  100. ncbi H2S induces a suspended animation-like state in mice
    Eric Blackstone
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
    Science 308:518. 2005
    ..We report that hydrogen sulfide can induce a suspended animation-like state in a nonhibernating species, the house mouse (Mus musculus)...
  101. pmc Novel insights into hydrogen sulfide--mediated cytoprotection
    John W Calvert
    Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Antioxid Redox Signal 12:1203-17. 2010
    b>Hydrogen sulfide (H(2)S) is a colorless, water soluble, flammable gas that has the characteristic smell of rotten eggs...

Research Grants68

  1. The assessment of hydrogen sulfide in vascular biology
    David Kraus; Fiscal Year: 2006
    b>Hydrogen sulfide (H2S) is produced in many mammalian tissues and has been detected in micromolar amounts in blood and brain tissue...
  2. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..or indirectly by maintaining an intricate balance among cellular homocysteine (Hcy), glutathione (GSH) and hydrogen sulfide (H2S) levels...
  3. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN JD O'KEEFE; Fiscal Year: 2012
    ..increases microbiota populations of sulfur-reducing bacteria (SRBs), which produce cytotoxic and genotoxic hydrogen sulfide as a terminal product...
  4. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    b>Hydrogen sulfide (H2S) has recently been identified as a physiologically important endogenous gaseous signaling molecule with a diverse array of biological activities...
  5. Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ..based on recent studies indicating that acrolein is detoxified by glutathione S-transferase P1 (GSTP1) and by hydrogen sulfide (H2S), a newly recognized endogenous mediator produced by (homo)cysteine metabolism by cystathionine [..
  6. Role of homocysteine in retinal disease
    Sylvia B Smith; Fiscal Year: 2013
    ..transsulfuration pathway" leading to formation of cysteine, which is then converted to glutathione (GSH), hydrogen sulfide (H2S), and/or taurine, the observed disrupted retinal structure/function may be due to decreased levels of ..
  7. Hydrogen Sulfide in Newborn Cerebral Circulation
    Charles W Leffler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A third gasotransmitter, joining NO and CO, is hydrogen sulfide (H2S) that is produced physiologically from L-cysteine catabolized by cystathionine 3-lyase (CSE) and cystathionine 2-synthase (CBS)...
  8. NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGS
    Solomon H Snyder; Fiscal Year: 2013
    ..We propose to elucidate Rhes-mTOR relationships. We also propose to extend our recent findings that hydrogen sulfide (H2S) is physiologically generated by cystathionine-gamma- lyase (CSE) in mammalian peripheral tissues and by ..
  9. Crystalline hydroxocobalamin and methemoglobin as a treatment of H2S intoxication
    PHILIPPE A HAOUZI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hydrogen sulfide (H2S) is a lethal gas regarded as a potential chemical threat by the Department of Homeland Security and a "chemical hazard immediately dangerous to life" by the Centers for Disease ..
  10. Gastrointestinal Smooth Muscle in Health &Disease
    Joseph H Szurszewski; Fiscal Year: 2012
    b>Hydrogen sulfide (H2S) is produced in the brain, liver and in the wall of many blood vessels. There is increasing evidence that H2S is also produced in the gastrointestinal tract and that it serves important physiological functions...
  11. IMPACT OF HYDROGEN SULFIDE ON OUTCOME OF CARDIAC ARREST AND CARDIOPULMONARY RESUS
    Fumito Ichinose; Fiscal Year: 2013
    ..Innovative approach is needed to improve the outcome of cardiac arrest and CPR. Hydrogen sulfide is a colorless gas with a characteristic rotten-egg odor found in various natural and industrial sources...
  12. Developing fluorescent probes for the endogenous gaseous transmitters NO and H2S
    MICHAEL PLUTH; Fiscal Year: 2013
    ..Nitric oxide (NO) and hydrogen sulfide (H2S) are now accepted as biologically important gaseous transmitters...
  13. 2010 Oxygen Radicals: Mechanisms that Underpin Redox Biology - a Gordon Research
    Garry R Buettner; Fiscal Year: 2010
    ..events in cardiovascular disease;biochemistry of thiol oxidation &thiol enzymes;nitrogen oxides &hydrogen sulfide;protein oxidation, redox changes &aging;mitochondria, central to redox balance;biomarkers &methods ..
  14. Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats
    Gerry R Boss; Fiscal Year: 2012
    ..We have found that three of these agents-hydrazine, sodium azide, and hydrogen sulfide, all of which are considered high priority chemical threats and for which no good antidote exists--bind with ..
  15. Nitrites as Antidotes for Hydrogen Sulfide Poisoning
    James Peterson; Fiscal Year: 2013
    ..At this time, there appears to be no FDA-approved antidote and/or reliable protocol for treating acute hydrogen sulfide (H2S) poisoning...
  16. Integrative Consequences of Hypoxia
    Nanduri R Prabhakar; Fiscal Year: 2013
    ..on the carotid body are due to ROS-mediated imbalance between inhibitory (carbon monoxide;CO) and excitatory (hydrogen sulfide;H2S) gaseous messengers...
  17. Hydrogen sulfide attenuates heart failure through Nrf2-mediated signaling
    JOHN WINTER CALVERT; Fiscal Year: 2013
    ..Recently, hydrogen sulfide (H2S) has been shown to be cardioprotective in various in vitro and in vivo models of cardiac injury...
  18. Phase II Clinical Trial to Evaluate the Benefits of Postconditioning in STEMI
    Jay H Traverse; Fiscal Year: 2013
    ..shed light on the mechanisms of benefit of Post C including measurements of nitrite anion (nitric oxide), hydrogen sulfide and reactive oxygen species...
  19. Time-resolved measurements of breath hydrogen sulfide
    STEVEN M MASSICK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hydrogen sulfide (H2S), once identified exclusively as a pernicious toxic gas, is now recognized as a key participant in a myriad of physiological functions...
  20. Mechanism of oxygen sensing by chemoreceptor cells
    Donghee Kim; Fiscal Year: 2013
    ..Recent studies suggest that hydrogen sulfide (H2S) is generated during hypoxia and mediates the hypoxia-induced increase in carotid sinus nerve activity ..
  21. Hydrogen Sulfide Metabolism: From Mechanism to Application
    MARILYN S JORNS; Fiscal Year: 2013
    b>Hydrogen sulfide (H2S) is the newest member of a small family of gaseous, biological signaling molecules, termed gasotransmitters. H2S is the only gasotransmitter that is enzymatically metabolized...
  22. HYDROGEN SULFIDE-RELEASING COMPOUNDS AND IOP REGULATION
    Ya Fatou Njie-Mbye; Fiscal Year: 2012
    ..pathway in mammalian tissues has stimulated a surge of interest in the biological significance and role of hydrogen sulfide (H2S), a colorless gas with pungent odor of rotten eggs in ocular tissues...
  23. FREE RADICAL LIPID PEROXIDATION DAMAGE
    ALOYS TAPPEL; Fiscal Year: 1991
    ..electrophoretic changes in specific proteins that may be polymerized; oxidation of methionine; and release of hydrogen sulfide. 4...
  24. Olfaction in the Psychosis Prodrome: Behavioral and ERP Measures
    R JURGEN KAYSER; Fiscal Year: 2010
    ..will be measured in 30 prodromal patients and 30 matched healthy controls to three concentrations of hydrogen sulfide during a detection task...
  25. VENTILATION CONTROL TO REDUCE AIRBORNE CONTAMINANTS
    PATRICK O SHAUGHNESSY; Fiscal Year: 2001
    ..component that can reach levels of 26 mg/m3, gases present in confinements in high amounts include methane, hydrogen sulfide, ammonia, and carbon dioxide...
  26. Mechanisms of the Response to Hydrogen Sulfide
    Dana L Miller; Fiscal Year: 2012
    ..As a postdoc with Dr. Mark Roth, Dr. Miller found that hydrogen sulfide (H2S), which is naturally produced by animal cells, increases lifespan and thermotolerance in C. elegans...
  27. Hydrogen sulfide and vascular remodeling
    Christopher G Kevil; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Experimental evidence is emerging that the gasotransmitter hydrogen sulfide serves an important role in the cardiovascular system especially during tissue ischemia...
  28. GLUTATHIONE PATHWAY TO THE FORMATION OF PHENOLS
    KHINGKAN LERTRATANANGKOON; Fiscal Year: 1992
    ..The toxicity could be due to the formation of hydrogen sulfide, or to the formation of thiocatechols and/or thioquinones. The specific aims of this proposed studies are: 1...
  29. R-HOMOCYSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 1999
    ..coli.The cloned rHCYase produces hydrogen sulfide from homocysteine and is not interfered with by cysteine...
  30. Novel Hydrogen Sulfide Sensors for Portable Monitors
    Stephen Williams; Fiscal Year: 2004
    ..SBIR project is the design, development, and demonstration of a better sensor technology for the detection of hydrogen sulfide Hydrogen sulfide is a colorless, flammable gas that is highly toxic It reacts with the enzymes in the blood ..
  31. Effects of Long-Term Low Level Hydrogen Sulfide Exposure
    Michael N Bates; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hydrogen sulfide (H2S) gas has high acute toxicity, but little is known about the effects of long-term, low-level exposures...
  32. PHYSIOLOGICAL FUNCTION OF ENDOGENOUS HYDROGEN SULFIDE
    David Schubert; Fiscal Year: 1999
    ....
  33. DEVELOPMENT OF INSTRUMENTS TO MEASURE HUMAN EXPOSURE
    JOSEPH STETTER; Fiscal Year: 1991
    ..In this study, we will develop and test recording dosimeters for carbon monoxide, nitrogen dioxide, hydrogen sulfide, formaldehyde, and ethylene oxide...
  34. Novel Hydrogen Sulfide Sensors for Portable Monitors
    MATTHEW HOOKER; Fiscal Year: 2001
    ..a low-cost micro analyzer for monitoring workplace exposures to a specific, and acutely toxic, gas, namely hydrogen sulfide. Recent work by Nanomaterials Research Corporation has shown that a new semiconductor compound is highly ..
  35. Mechanisms of the Response to Hydrogen Sulfide
    Dana L Miller; Fiscal Year: 2010
    ..b>Hydrogen sulfide (H2S), which is naturally produced by animal cells, increases lifespan and thermotolerance in C. elegans...
  36. IN SITU, REMOTELY INTERROGATABLE MAGNETOCHEMICAL SENSORS
    Craig Grimes; Fiscal Year: 1999
    ..4) Develop polymers or other space layer materials for applications including glucose, CO2, hydrogen sulfide and hydrazine. (3) Evaluate the robustness of the different polymer layers...
  37. ENVIRONMENTAL MODULATION OF INTESTINAL SULFIDOGENS AND I
    H Gaskins; Fiscal Year: 2000
    ..their ability to use sulfate as a terminal electron acceptor, culminating in the production of the toxic gas hydrogen sulfide (H2S)...
  38. GENE REGULATION DURING INTERMITTENT HYPOXIA
    Nanduri Prabhakar; Fiscal Year: 2003
    ....
  39. Consequences of Neonatal Hypoxia
    Nanduri Prabhakar; Fiscal Year: 2009
    ..Understanding the consequences of neonatal IH provide insights into how neonatal intermittent hypoxia caused by recurrent apneas affects the ventilation in premature infants. Experimental Animal Model: Rat Pups. ..
  40. Myicardial injury: role of poly (ADP-ribose) synthetase
    Csaba Szabo; Fiscal Year: 2005
    ..Further, based on exciting preliminary data, the final, fifth aim is focusing in establishing the role of PARS in myocardial preconditioning. ..
  41. PARS INHIBITOR FOR THE THERAPY OF CIRCULATORY SHOCK
    Ludmila Belayev; Fiscal Year: 2003
    ..The current project will enable the applicants to move forward in two years, near to the level of the beginning of Phase II efficacy trial in septic patients. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  42. Novel preservation fluid for organ transplantation
    Jon Mabley; Fiscal Year: 2003
    ..abstract_text> ..
  43. Adenosine-3 agonists for the suppression of arthritis
    Csaba Szabo; Fiscal Year: 2003
    ..A novel A3 receptor agonist may represent a useful anti-inflammatory adjunct to current therapeutic regimens; funding of the current SBIR Phase II will allow for starting human safety trials in 2 years. ..
  44. Peroxynitrate neutralizing agents for stroke therapy
    Csaba Szabo; Fiscal Year: 2003
    ....
  45. Ultrapotent PARS inhibitor for CNS trauma
    Csaba Szabo; Fiscal Year: 2003
    ..Estimated worldwide revenues after market entry and maturation (ca. 4 years after FDA approval)=$750 million (annual). ..
  46. Poly(ADP-ribose) synthetase inhibition and diabetes
    Csaba Szabo; Fiscal Year: 2004
    ....
  47. Poly(ADP-ribose)Polymerase & Doxorubicin Cardiotoxicity
    Jon Mabley; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: The annual anticipated revenues for an effective therapeutic to prevent anti-cancer-drug induced cardiodepression is over $100 million in the US alone. ..
  48. Poly(ADP-ribose)and diabetic erectile dysfunction
    FANGMING ZUO; Fiscal Year: 2004
    ..If these studies confirm that Inotek's PARP inhibitor is effective in improving erectile function in diabetes, a Phase II component will be triggered, which will focus on formal preclinical safety testing. ..
  49. PARS and peroxynitrite induced cell death
    Csaba Szabo; Fiscal Year: 2009
    ..4 To establish the role of Bel family proteins in the regulation of calcium homeostasis during peroxynitrite-induced cell death. The studies proposed here have broad pathophysiological relevance. ..
  50. Mechanisms of cardiovascular dysfunction in diabetes
    Csaba Szabo; Fiscal Year: 2005
    ..The final aim of the study is to investigate the activation of PARP in human microvasculature, and to correlate the degree of PARP activation with the degree of endothelial dysfunction in humans. ..
  51. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2007
    ..denticola to produce H2S from glutathione. The outcomes will elucidate the mechanisms of action that each member of the enzyme pathway plays in the virulence capacity of T. denticola. ..
  52. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  53. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  54. Nutritional Regulation of y-Glutamylcysteine Synthetase
    MARTHA STIPANUK; Fiscal Year: 2007
    ..Capacity for GSH synthesis, availability of the precursor amino acid cysteine, and steady-state GSH levels all contribute to the body's ability to defend itself against oxidative or chemical stressors. ..
  55. COMMUNITY HEALTH & ENVIRONMENTAL REAWAKENING
    Steven Wing; Fiscal Year: 2007
    ....
  56. AGRICULTURAL DUST AND CHILDHOOD ASTHMA SYMPTOMS
    Steve Wing; Fiscal Year: 2004
    ....
  57. Community Health Effects of Industrial Hog Operations
    Steven Wing; Fiscal Year: 2005
    ..Airborne emissions are composed of hundreds of agents including hydrogen sulfide, ammonia, volatile organic compounds, and dusts or particulate matter that contains biological materials ..
  58. EXTRINSIC CONTROL OF GASTROINTESTINAL MOTILITY
    JOSEPH SZURSZEWSKI; Fiscal Year: 2005
    ..The basic knowledge derived from our studies is expected to improve the understanding of the functional significance of the molecular components of mechanosensitivity and chemosensitivity of intestinal afferent nerves. ..
  59. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  60. Role of lefty in implantation
    Siamak Tabibzadeh; Fiscal Year: 2006
    ..These results are expected to demonstrate the feasibility of using lefty protein as a target in therapeutic interventions for infertility and related disorders and abortion. ..
  61. Mechanism of Vascular Remodeling in Hyperhomocysteinemia
    Suresh C Tyagi; Fiscal Year: 2010
    ..This study will provide new insights into the mechanism of arterial remodeling and will have therapeutic ramifications for vessel wall disease. ..
  62. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 2003
    ..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
  63. The Sulfur/Glutamate Circuitry in the Neuroimmune System
    Ruma Banerjee; Fiscal Year: 2009
    ..We propose to study the metabolic interdependence between astrocytes, neurons and T cells in performing these critical functions under normal and neurotoxic conditions. ..
  64. Implications of Endothelial-Myocyte Uncoupling in Cardiac Arrhythmia
    Suresh C Tyagi; Fiscal Year: 2010
    ..These studies will delineate the mechanism of Hcy-dependent endothelial-myocyte uncoupling in cardiac arrhythmia and failure, and will have therapeutic ramifications for sudden cardiac death. ..
  65. 2008 Thiol-based Redox Regulation and Signaling Gordon Research Conference
    Ruma Banerjee; Fiscal Year: 2008
    ..g. in biophysical methods, bioinformatics and animal model systems, with physicians, the meeting is expected to further stimulate collaborations and catalyze scientific progress. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  66. Microbial Markers for Periodontal Disease in Children
    Daniel Fine; Fiscal Year: 2005
    ....
  67. 2007 Cellular Osmoregulation: Sensors, Tranducers & Regulators Gordon Research Co
    PAUL YANCEY; Fiscal Year: 2007
    ..In all aspects of the conference, the organizers are working to promote the involvement of women, minorities and people with disabilities. [unreadable] [unreadable] [unreadable]..
  68. NO production and S-nitrosylation in liver vasculature
    Yasuko Iwakiri; Fiscal Year: 2008
    ..The School of Medicine has pledged protected time for the candidate during this further training period prior to functioning as an independent investigator. ..