fluorides

Summary

Summary: Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.

Top Publications

  1. ncbi Risk-benefit balance in the use of fluoride among young children
    L G Do
    Australian Research Centre for Population Oral Health, School of Dentistry, The University of Adelaide, Australia 5005
    J Dent Res 86:723-8. 2007
  2. ncbi Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping
    Feng Wang
    Department of Chemistry, National University of Singapore, 117543, Singapore
    Nature 463:1061-5. 2010
  3. pmc Widespread genetic switches and toxicity resistance proteins for fluoride
    Jenny L Baker
    Department of Chemistry, Yale University, Box 208103, New Haven, CT 06520, USA
    Science 335:233-5. 2012
  4. ncbi Use of fluorides in dental caries management
    C H Chu
    Faculty of Dentistry, University of Hong Kong, China
    Gen Dent 58:37-43; quiz 44-5, 79-80. 2010
  5. pmc Ultrasmall monodisperse NaYF(4):Yb(3+)/Tm(3+) nanocrystals with enhanced near-infrared to near-infrared upconversion photoluminescence
    Guanying Chen
    Institute for Lasers, Photonics, and Biophotonics, The State University of New York at Buffalo, Buffalo, New York 14260, USA
    ACS Nano 4:3163-8. 2010
  6. ncbi Dental fluorosis in permanent incisor teeth in relation to water fluoridation, social deprivation and toothpaste use in infancy
    E D Tabari
    Newcastle City Health NHS Trust, Walkergate Centre, Newcastle upon Tyne
    Br Dent J 189:216-20. 2000
  7. ncbi Fluoride in drinking water and its removal
    - Meenakshi
    Centre for Rural Development and Technology, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, India
    J Hazard Mater 137:456-63. 2006
  8. ncbi Timing of fluoride intake in relation to development of fluorosis on maxillary central incisors
    Liang Hong
    Department of Preventive and Community Dentistry, University of Iowa, Iowa City, IA 52242 1010, USA
    Community Dent Oral Epidemiol 34:299-309. 2006
  9. ncbi Prospective study of the association between fluoride intake and dental fluorosis in permanent teeth
    C C Martins
    School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Caries Res 42:125-33. 2008
  10. ncbi Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals
    Dev K Chatterjee
    Division of Bioengineering, National University of Singapore, Singapore 117574, Singapore
    Biomaterials 29:937-43. 2008

Detail Information

Publications383 found, 100 shown here

  1. ncbi Risk-benefit balance in the use of fluoride among young children
    L G Do
    Australian Research Centre for Population Oral Health, School of Dentistry, The University of Adelaide, Australia 5005
    J Dent Res 86:723-8. 2007
    ..Evaluation of the risk-benefit balance of fluoride exposure provides evidence to assist in the formulation of appropriate guidelines for fluoride use...
  2. ncbi Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping
    Feng Wang
    Department of Chemistry, National University of Singapore, 117543, Singapore
    Nature 463:1061-5. 2010
    ....
  3. pmc Widespread genetic switches and toxicity resistance proteins for fluoride
    Jenny L Baker
    Department of Chemistry, Yale University, Box 208103, New Haven, CT 06520, USA
    Science 335:233-5. 2012
    ..Our findings indicate that most organisms are naturally exposed to toxic levels of fluoride and that many species use fluoride-sensing RNAs to control the expression of proteins that alleviate the deleterious effects of this anion...
  4. ncbi Use of fluorides in dental caries management
    C H Chu
    Faculty of Dentistry, University of Hong Kong, China
    Gen Dent 58:37-43; quiz 44-5, 79-80. 2010
    Fluoride is commonly and widely used to prevent and even arrest caries. The clinical effects of fluorides depend on the chemical compounds utilized and the methods used to apply the fluoride ion to the surface of the tooth...
  5. pmc Ultrasmall monodisperse NaYF(4):Yb(3+)/Tm(3+) nanocrystals with enhanced near-infrared to near-infrared upconversion photoluminescence
    Guanying Chen
    Institute for Lasers, Photonics, and Biophotonics, The State University of New York at Buffalo, Buffalo, New York 14260, USA
    ACS Nano 4:3163-8. 2010
    ..An optimization of both size and UC PL efficiency of NIR-to-NIR nanocrystals provides us with highly efficient optical imaging probes for bioapplications...
  6. ncbi Dental fluorosis in permanent incisor teeth in relation to water fluoridation, social deprivation and toothpaste use in infancy
    E D Tabari
    Newcastle City Health NHS Trust, Walkergate Centre, Newcastle upon Tyne
    Br Dent J 189:216-20. 2000
    ....
  7. ncbi Fluoride in drinking water and its removal
    - Meenakshi
    Centre for Rural Development and Technology, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, India
    J Hazard Mater 137:456-63. 2006
    ..It has been concluded that the selection of treatment process should be site specific as per local needs and prevailing conditions as each technology has some limitations and no one process can serve the purpose in diverse conditions...
  8. ncbi Timing of fluoride intake in relation to development of fluorosis on maxillary central incisors
    Liang Hong
    Department of Preventive and Community Dentistry, University of Iowa, Iowa City, IA 52242 1010, USA
    Community Dent Oral Epidemiol 34:299-309. 2006
    ..This study reports the relationships of fluoride intake during the first 48 months of life with fluorosis on early-erupting permanent teeth...
  9. ncbi Prospective study of the association between fluoride intake and dental fluorosis in permanent teeth
    C C Martins
    School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Caries Res 42:125-33. 2008
    ..To evaluate the relationship between fluoride intake and dental fluorosis in permanent central incisors and first molars...
  10. ncbi Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals
    Dev K Chatterjee
    Division of Bioengineering, National University of Singapore, Singapore 117574, Singapore
    Biomaterials 29:937-43. 2008
    ..To the best of our knowledge, this represents the first demonstration of use of upconversion fluorophores for cellular and tissue imaging...
  11. ncbi Reasons for the caries decline: what do the experts believe?
    D Bratthall
    Department of Cariology, Faculty of Odontology, University of Lund, Sweden
    Eur J Oral Sci 104:416-22; discussion 423-5, 430-2. 1996
    ..The 25 items were divided into main groups under the heading of diet, fluorides, plaque, saliva, dentist/dental materials and other factors...
  12. pmc Influence of genetic background on fluoride metabolism in mice
    J G Carvalho
    Department of Biological Sciences, Bauru Dental School, University of Sao Paulo, Al Octavio Pinheiro Brisolla, 9 75, Bauru SP 17012 901, Sao Paulo, Brazil
    J Dent Res 88:1054-8. 2009
    ..In conclusion, these strains differ with respect to several features of F metabolism, and amelogenesis in the 129P3/J strain seems to be unaffected by high F exposure...
  13. ncbi Reversible inhibition of Escherichia coli inorganic pyrophosphatase by fluoride: trapped catalytic intermediates in cryo-crystallographic studies
    V R Samygina
    A V Shubnikov Institute of Crystallography, Russian Academy of Sciences, Leninsky Pr 59, 119333 Moscow, Russia
    J Mol Biol 366:1305-17. 2007
    ..We further determined the crystal structure of the Arg43Gln mutant variant of E-PPase complexed with one phosphate and four Mn ions...
  14. ncbi Polymer-coated NaYF₄:Yb³⁺, Er³⁺ upconversion nanoparticles for charge-dependent cellular imaging
    Jiefu Jin
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    ACS Nano 5:7838-47. 2011
    ..Furthermore, this study provides important guidance for the development of UCNPs as specific intracellular nanoprobes, allowing us to control the UCNP-cell interactions by tuning surface properties...
  15. pmc Fluoride's effects on the formation of teeth and bones, and the influence of genetics
    E T Everett
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina at Chapel Hill, 228 Brauer Hall, CB 7450, Chapel Hill, NC 27599, USA
    J Dent Res 90:552-60. 2011
    b>Fluorides are present in the environment. Excessive systemic exposure to fluorides can lead to disturbances of bone homeostasis (skeletal fluorosis) and enamel development (dental/enamel fluorosis)...
  16. ncbi Fluoride: its role in dentistry
    Livia Maria Andalo Tenuta
    Biochemistry and Cariology Piracicaba Dental School, University of Campinas UNICAMP, Piracicaba, SP, Brazil
    Braz Oral Res 24:9-17. 2010
    ....
  17. ncbi Dental fluorosis: variability among different inbred mouse strains
    E T Everett
    Oral Facial Genetics Division, Department of Oral Facial Development, Indiana University School of Dentistry, Indianapolis 46202, USA
    J Dent Res 81:794-8. 2002
    ..These observations support the contribution of a genetic component in the pathogenesis of dental fluorosis...
  18. pmc Fluoride effects on bone formation and mineralization are influenced by genetics
    M Mousny
    Orthopaedic Research Laboratory, Cliniques Universitaires Saint Luc, Catholic University of Louvain, Brussels, Belgium
    Bone 43:1067-74. 2008
    ..In this paper, the structural and material properties of the bone were evaluated to explain the previously observed changes in mechanical properties...
  19. ncbi Proteomic analysis of kidney in rats chronically exposed to fluoride
    Claudia A N Kobayashi
    Bauru Dental School, University of Sao Paulo, Bauru, SP, Brazil
    Chem Biol Interact 180:305-11. 2009
    ..Thus, proteomic analysis can provide new insights into the alterations in renal metabolism after F exposure, even in low doses...
  20. pmc A longitudinal study of dental caries risk among very young low SES children
    John J Warren
    Department of Preventive and Community Dentistry, The University of Iowa, Iowa City, IA 52242 1010, USA
    Community Dent Oral Epidemiol 37:116-22. 2009
    ..The purpose of this study was to assess baseline risk factors for 18-month caries prevalence as part of a longitudinal study of high-risk children...
  21. pmc A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging
    Eunsung Lee
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 334:639-42. 2011
    ..Late-stage fluorination enables the synthesis of conventionally unavailable positron emission tomography (PET) tracers for anticipated applications in pharmaceutical development as well as preclinical and clinical PET imaging...
  22. ncbi Sources of dietary fluoride intake in 6-7-year-old English children receiving optimally, sub-optimally, and non-fluoridated water
    Fatemeh V Zohouri
    School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK
    J Public Health Dent 66:227-34. 2006
    ....
  23. ncbi Fluoride and children's intelligence: a meta-analysis
    Qin Qing Tang
    Department of Pathology, Nanjing University School of Medicine, Nanjing Jinling Hospital, Nanjing, Jiangsu 210002, People s Republic of China
    Biol Trace Elem Res 126:115-20. 2008
    ..51 to 3.55; p < 0.01) using a random-effect model, which means that children who live in a fluorosis area have five times higher odds of developing low IQ than those who live in a nonfluorosis area or a slight fluorosis area...
  24. ncbi Mechanisms of action of fluoride for caries control
    Marilia Afonso Rabelo Buzalaf
    Department of Biological Sciences, Orthodontics and Public Health, Bauru Dental School, University of Sao Paulo, Bauru, Brazil
    Monogr Oral Sci 22:97-114. 2011
    ..Evidence also supports fluoride's systemic mechanism of caries inhibition in pit and fissure surfaces of permanent first molars when it is incorporated into these teeth pre-eruptively...
  25. ncbi Fluoride intake by Brazilian children from two communities with fluoridated water
    Saul M Paiva
    Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Community Dent Oral Epidemiol 31:184-91. 2003
    ..To determine total daily fluoride intake by young children from two communities in a developing country...
  26. ncbi Upconversion multicolor fine-tuning: visible to near-infrared emission from lanthanide-doped NaYF4 nanoparticles
    Feng Wang
    Department of Chemistry, National University of Singapore, Singapore 117543
    J Am Chem Soc 130:5642-3. 2008
    ..The approach allows access to a wide range of luminescence emission from visible to near-infrared by single-wavelength excitation...
  27. ncbi Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation
    Kaori Kubota
    Department of Cytokine Biology, Forsyth Institute, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    J Biol Chem 280:23194-202. 2005
    ..Ire1 levels appeared induced by fluoride treatment, indicating that ER stress may play a role in dental fluorosis. Low dose fluoride, such as that present in fluoridated drinking water, did not induce ER stress...
  28. ncbi Caries-preventive effect of fluoride toothpaste: a systematic review
    Svante Twetman
    Department of Odontology, Pediatric Dentistry, Umea University, Umea, Sweden
    Acta Odontol Scand 61:347-55. 2003
    ..In conclusion, this review reinforced the importance of daily toothbrushing with fluoridated toothpastes for preventing dental caries, although long-term studies in age groups other than children and adolescents are still lacking...
  29. pmc Arsenic and fluoride exposure in drinking water: children's IQ and growth in Shanyin county, Shanxi province, China
    San xiang Wang
    Shanxi Institute for Prevention and Treatment of Endemic Disease, Linfen, 041000 Shanxi Province, People s Republic of China
    Environ Health Perspect 115:643-7. 2007
    ....
  30. ncbi Fluoride and organic weak acids as modulators of microbial physiology
    Robert E Marquis
    Department of Microbiology and Immunology and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642 8672, USA
    FEMS Microbiol Rev 26:493-510. 2003
    ..Hopefully, this review will stimulate interest in the antimicrobial effects of fluoride or other weak acids and lead to more effective use of the agents for disease control and other applications...
  31. ncbi Fluoride intake levels in relation to fluorosis development in permanent maxillary central incisors and first molars
    Liang Hong
    Department of Dental Public Health and Behavioral Science, School of Dentistry, University of Missouri Kansas City, Kansas City, MO, USA
    Caries Res 40:494-500. 2006
    ..The study suggests that fluorosis prevalence is related to elevated fluoride intake when averaged over the first 3 years of life, but is even more strongly related to fluoride intake that is elevated for all of the first 3 years of life...
  32. pmc High contrast in vitro and in vivo photoluminescence bioimaging using near infrared to near infrared up-conversion in Tm3+ and Yb3+ doped fluoride nanophosphors
    Marcin Nyk
    Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260 3000, USA
    Nano Lett 8:3834-8. 2008
    ..No apparent cytotoxicity was observed. Subsequent animal imaging studies were performed using Balb-c mice injected intravenously with up-converting nanophosphors, demonstrating the high contrast PL imaging in vivo...
  33. ncbi The science and practice of caries prevention
    J D Featherstone
    Department of Preventive and Restorative Dental Sciences, University of California, San Francisco 94143, USA
    J Am Dent Assoc 131:887-99. 2000
    ..Protective factors--which include salivary calcium, phosphate and proteins, salivary flow, fluoride in saliva, and antibacterial components or agents--can balance, prevent or reverse dental caries...
  34. ncbi Silver compounds used in dentistry for caries management: a review
    J J Y Peng
    Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
    J Dent 40:531-41. 2012
    ..The aim of this review is to examine the evidence supporting the therapeutic use of silver in dentistry and the outcomes from the clinical trials, as well as mode of action and biocompatibility...
  35. pmc Improved 18F labeling of peptides with a fluoride-aluminum-chelate complex
    William J McBride
    Immunomedics, Inc, Morris Plains, New Jersey 07950, USA
    Bioconjug Chem 21:1331-40. 2010
    ..The IMP467 peptide could be labeled up to 115 GBq/micromol (3100 Ci/mmol), with a total reaction and purification time of 30 min without chromatographic purification...
  36. ncbi Considerations on optimal fluoride intake using dental fluorosis and dental caries outcomes--a longitudinal study
    John J Warren
    Department of Preventive and Community Dentistry, University of Iowa, Iowa City, IA 52242 1010, USA
    J Public Health Dent 69:111-5. 2009
    ....
  37. ncbi Fluoridated toothpaste: usage and ingestion of fluoride by 4- to 6-yr-old children in England
    Fatemeh V Zohoori
    Health and Social Care Institute, Teesside University, Middlesbrough, UK
    Eur J Oral Sci 120:415-21. 2012
    ..25 g), only one child had a daily fluoride intake that exceeded the tolerable upper intake level of 0.1 mg kg(-1) of body weight for this age group...
  38. ncbi Influence of fluoride, hydrogen peroxide and lactic acid on the corrosion resistance of commercially pure titanium
    G Mabilleau
    INSERM, EMI 0335 LHEA, Faculte de Medecine, F 49045 Angers Cedex, France
    Acta Biomater 2:121-9. 2006
    ..AFM appeared to be more sensitive than SEM in evaluating the corrosion of the titanium. Chemical species, either environmental or those released by macrophages and bacteria, can provoke a marked attack of the titanium surface...
  39. pmc The effective use of fluorides in public health
    Sheila Jones
    British Fluoridation Society, Booth Hall Children s Hospital, Manchester, England
    Bull World Health Organ 83:670-6. 2005
    ..Early research and development was concerned with waterborne fluorides, both naturally occurring and added, and their effects on the prevalence and incidence of dental caries and ..
  40. ncbi The precision and sensitivity of (18)F-fluoride PET for measuring regional bone metabolism: a comparison of quantification methods
    Musib Siddique
    King s College London, Osteoporosis Screening and Research Unit, Guy s Hospital, London, UK
    J Nucl Med 52:1748-55. 2011
    ....
  41. ncbi Effects of alendronate on bone metabolism in glucocorticoid-induced osteoporosis measured by 18F-fluoride PET: a prospective study
    Kenzo Uchida
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    J Nucl Med 50:1808-14. 2009
    ....
  42. ncbi Fatigue and fluoride corrosion on Streptococcus mutans adherence to titanium-based implant/component surfaces
    Cassia Bellotto Correa
    Department of Dental Materials and Prosthodontics, UNESP Sao Paulo State University, Araraquara, SP, Brazil
    J Prosthodont 18:382-7. 2009
    ..The influence of fatigue and the fluoride ion corrosion process on Streptococcus mutans adherence to commercially pure Titanium (Cp Ti) implant/component set surfaces were studied...
  43. ncbi Core-shell NaYF4:Yb3+,Tm3+@FexOy nanocrystals for dual-modality T2-enhanced magnetic resonance and NIR-to-NIR upconversion luminescent imaging of small-animal lymphatic node
    Ao Xia
    Advanced Materials Laboratory and Department of Chemistry, Fudan University, Shanghai, PR China
    Biomaterials 32:7200-8. 2011
    ..Moreover, the toxicity of NaYF(4):Yb(3+),Tm(3+)@Fe(x)O(y) nanocrystals has also been evaluated by MTT assay, IC50 values, and histological analysis of lymphatic node sections...
  44. ncbi Economic evaluation of dental caries prevention: a systematic review
    Carina Källestål
    National Institute of Public Health, Stockholm, Sweden
    Acta Odontol Scand 61:341-6. 2003
    ..The scarcity of well-conducted studies, as well as contradictory evidence in the reviewed articles, makes it difficult to judge the health-economic effect of the studied caries-prevention methods...
  45. pmc Morphologically controlled synthesis of colloidal upconversion nanophosphors and their shape-directed self-assembly
    Xingchen Ye
    Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:22430-5. 2010
    ..This dramatically improved nanophosphor synthesis together with insights from shape-directed assembly will advance the investigation of an array of emerging biological and energy-related nanophosphor applications...
  46. ncbi Effects of fluorides on apoptosis and activation of human umbilical vein endothelial cells
    M Szczepanski
    Department of Neonatology and Intensive Neonatal Care Unit, Medical University of Bialystok, Bialystok, Poland
    Oral Dis 18:280-4. 2012
    To determine the effects of fluorides on endothelial functioning.
  47. ncbi How safe are the global water coverage figures? Case study from Madhya Pradesh, India
    Sam Godfrey
    UNICEF, 1440 Zimbabwe Avenue, Maputo, Mozambique
    Environ Monit Assess 176:561-74. 2011
    ..In Indore Zone, the coverage of safe water reduced from 42% to 25% through the inclusion of the water safety parameters. The study recommends the inclusion of water quality/safety data in reported data under the UNICEF/WHO JMP...
  48. ncbi Treatment of high fluoride concentration water by MgAl-CO3 layered double hydroxides: kinetic and equilibrium studies
    Liang Lv
    West Branch of Zhejiang University of Technology, 78 Jiu Hua Da Dao, Ke Cheng District, Quzhou City, Zhejiang 324000, China
    Water Res 41:1534-42. 2007
    ..2+/-5.26 and 72.6+/-4.52kJ/mol, respectively, suggesting that the rapid step is controlled by diffusion processes, whilst the second step is controlled by the reaction of fluoride with the LDHs...
  49. ncbi Is the use of fluoride toothpaste optimal? Knowledge, attitudes and behaviour concerning fluoride toothpaste and toothbrushing in different age groups in Sweden
    Olga Jensen
    Public Dental Health, Vastra Gotaland Region, Gothenburg, Sweden
    Community Dent Oral Epidemiol 40:175-84. 2012
    ..The aim of this study was to evaluate self-care routines in a population by identifying knowledge, attitudes and behaviour relating to fluoride toothpaste and toothbrushing habits...
  50. pmc Fluoride ion encapsulation by Mg2+ ions and phosphates in a fluoride riboswitch
    Aiming Ren
    Structural Biology Program, Memorial Sloan Kettering Center, New York, New York 10065, USA
    Nature 486:85-9. 2012
    ..The T. petrophila fluoride riboswitch probably functions in gene regulation through a transcription termination mechanism...
  51. ncbi Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children
    Qing hui Zhi
    Guangdong Provincial Key Laboratory of Stomatology and School of Stomatology, Sun Yat Sen University, Guangzhou, China
    J Dent 40:962-7. 2012
    ....
  52. ncbi Mechanical properties of one and two-step fluoridated orthodontic resins submitted to different pH cycling regimes
    Paula Passalini
    School of Dentistry of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Braz Oral Res 24:197-203. 2010
    ..05). It could be concluded that Transbond Plus Color Change resin presented better shear bond strength and adhesive remnant index when submitted to high cariogenic challenge, in comparison with Orthodontic Fill Magic...
  53. ncbi The genetic influence on bone susceptibility to fluoride
    M Mousny
    Orthopaedic Research Laboratory, Cliniques Universitaires Saint Luc, Catholic University of Louvain, Brussels, Belgium
    Bone 39:1283-9. 2006
    ..Nevertheless, to date, only few animal studies explore an underlying genetic basis for extrinsic factors effect such as fluoride effect on bone metabolism...
  54. pmc Association between socioeconomic factors and the choice of dentifrice and fluoride intake by children
    Carolina Castro Martins
    Department of Paediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Int J Environ Res Public Health 8:4284-99. 2011
    ..The amount of dentifrice used can strongly increase the risk of exposure to higher doses of F, regardless of the type of dentifrice...
  55. ncbi Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy
    Raffaella Docimo
    University of Rome at Tor Vergata, Department of Odonto Stomatology Cattedra Di Pedodonzia, Rome, Italy
    J Clin Dent 20:17-22. 2009
    ..75% potassium chloride, and 1450 ppm fluoride as sodium fluoride (NaF)...
  56. ncbi Cochrane reviews of randomized trials of fluoride therapies for preventing dental caries
    V C C Marinho
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Institute of Dentistry, Turner Street, London, UK
    Eur Arch Paediatr Dent 10:183-91. 2009
    ..To present the evidence summarized in the Cochrane fluoride reviews...
  57. ncbi Brick tea fluoride as a main source of adult fluorosis
    Jin Cao
    Tea and Health Laboratory, Xiangya School of Medical Sciences, Central South University, Changsha 410078, Hunan, PR China
    Food Chem Toxicol 41:535-42. 2003
    ..The results suggest that this brick tea-type fluorosis had even more severe adverse effects on human health compared with both the water-type and coal combustion-type fluorosis that occurred in other areas of China...
  58. ncbi Overview of the clinical evidence for the use of NovaMin in providing relief from the pain of dentin hypersensitivity
    Linda Gendreau
    GlaxoSmithKline Consumer Healthcare Weybridge, Surrey, UK
    J Clin Dent 22:90-5. 2011
    ..This article reviews the available literature and finds support based on randomized controlled clinical trials for the use of NovaMin in anhydrous toothpaste formulations in providing relief of pain from dentin hypersensitivity...
  59. ncbi Global trends in dental fluorosis from 1980 to 2000: a systematic review
    A Khan
    Department of Community Dentistry, Faculty of Dentistry, University of Limpopo
    SADJ 60:418-21. 2005
    ..To determine trends in fluorosis prevalence at water fluoride levels <0.3, >0.3 to <0.7, and >0.7 to 1.4 ppm from 1980 to 2000...
  60. pmc Composition tuning the upconversion emission in NaYF4:Yb/Tm hexaplate nanocrystals
    Hua Zhang
    Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA
    Nanoscale 3:963-6. 2011
    ....
  61. ncbi Determinants of oral health behaviour among Iranian dentists
    Hadi Ghasemi
    Department of Oral Public Health, Institute of Dentistry, University of Helsinki, Finland
    Int Dent J 57:237-42. 2007
    ..To study the oral health behaviour of Iranian dentists...
  62. ncbi Differential effects of teriparatide on regional bone formation using (18)F-fluoride positron emission tomography
    Michelle L Frost
    Osteoporosis Research Unit, Division of Imaging Sciences, King s College London, Guy s Campus, London, UK
    J Bone Miner Res 26:1002-11. 2011
    ..We conclude that the changes in bone formation rate during teriparatide treatment as measured by (18)F(-) PET differ at different skeletal sites, with larger increases in cortical bone than at trabecular sites...
  63. pmc Genetic background influences fluoride's effects on osteoclastogenesis
    Dong Yan
    Dental Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Bone 41:1036-44. 2007
    ..The expected anabolic effects were observed in B6 and novel actions hallmarked by enhanced osteoclastogenesis shifts in hematopoietic cell differentiation in the C3H strain...
  64. ncbi Fluoride in dental erosion
    Ana Carolina Magalhaes
    Bauru Dental School, University of Sao Paulo, Bauru, Brazil
    Monogr Oral Sci 22:158-70. 2011
    ..the formation of a protective layer on dental hard tissue, which is composed of CaF(2) (in case of conventional fluorides like amine fluoride or sodium fluoride) or of metal-rich surface precipitates (in case of titanium tetrafluoride ..
  65. ncbi Fluoride and mineralized tissues
    Debbie Chachra
    Franklin W Olin College of Engineering, Needham, MA 02492, USA
    Crit Rev Biomed Eng 36:183-223. 2008
    ..These effects have been observed in communities where the local drinking water has naturally high fluoride levels. Understanding the influence of fluoride on mineralized tissues is, therefore, of considerable significance...
  66. ncbi Effects of different kinds of fluorides on enolase and ATPase activity of a fluoride-sensitive and fluoride-resistant Streptococcus mutans strain
    C van Loveren
    Department of Cariology, Endodontology, Pedodontology, Academic Centre for Dentistry Amsterdam ACTA, Amsterdam, The Netherlands
    Caries Res 42:429-34. 2008
    ..C180-2 and its fluoride-resistant mutant strain C180-2 FR were preincubated at pH 7 or 4 with NaF, the amine fluorides Olaflur and Dectaflur and amine chloride controls...
  67. ncbi Antibiofilm activity of nanosized magnesium fluoride
    Jonathan Lellouche
    The Mina and Everard Goodman Faculty of Life Sciences, The Institute for Advanced Materials and Nanotechnology, Bar Ilan University, Ramat Gan, Israel
    Biomaterials 30:5969-78. 2009
    ..The MgF(2) coated surfaces effectively restricted biofilm formation of the tested bacteria. Taken together these results highlight the potential for developing MgF(2) nanoparticles in order to inhibit bacterial infections...
  68. ncbi Detection of bone metastases in patients with lung cancer: 99mTc-MDP planar bone scintigraphy, 18F-fluoride PET or 18F-FDG PET/CT
    Stefan Kruger
    Medical Clinic II, University Hospital, Ulm, Germany
    Eur J Nucl Med Mol Imaging 36:1807-12. 2009
    ....
  69. ncbi Strategies to enhance the biological effects of fluoride on dental biofilms
    H Koo
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Adv Dent Res 20:17-21. 2008
  70. ncbi Combination effect of fluoride dentifrices and varnish on deciduous enamel demineralization
    Alessandra Gatti
    Departamento de Odontopediatria, Faculdade de Odontologia, São Leopoldo Mandic, Campinas, SP, Brazil
    Braz Oral Res 25:433-8. 2011
    ..05). The data suggest that the combination of F-varnish with dentifrices containing 500 and 1100 ppm F is not more effective in reducing demineralization in primary teeth than the isolated effect of dentifrice containing 1100 ppm F...
  71. ncbi Effect of fluoridated bleaching gels on the remineralization of predemineralized bovine enamel in vitro
    Peter Tschoppe
    Department of Operative Dentistry and Periodontology, University School of Dental Medicine, CharitéCentrum 3, Germany
    J Dent 37:156-62. 2009
    ..This study evaluated possible differences regarding the remineralization of predemineralized enamel after exposure to fluoridated or non-fluoridated bleaching gels...
  72. ncbi The effect of fluoride therapies on the morphology of bleached human dental enamel
    Stella da Silva Ferreira
    Deparment of Restorative Dentistry, University of Sao Paulo, FOUSP, SP, Brazil
    Microsc Res Tech 74:512-6. 2011
    ..These morphological changes were higher after the application of 1.23% acidulated fluoride gel...
  73. ncbi Pre and post natal exposure of fluoride induced oxidative macromolecular alterations in developing central nervous system of rat and amelioration by antioxidants
    Piler Mahaboob Basha
    Department of Zoology, Bangalore University, Bangalore, 560056, India
    Neurochem Res 35:1017-28. 2010
    ..The administration of antioxidants remedied the disquiet caused by high fluoride exposure at extreme vulnerable periods of life...
  74. ncbi Influence of methionine and vitamin E on fluoride concentration in bones and teeth of rats exposed to sodium fluoride in drinking water
    Iwona Błaszczyk
    Department of Biochemistry, Silesian Medical University, 19 Jordana Str, 41 808 Zabrze, Poland
    Biol Trace Elem Res 146:335-9. 2012
    Increased exposure to fluorine-containing compounds leads to accumulation of fluorides in hard tissues of bones and teeth, which may result in numerous skeletal and dental disorders...
  75. ncbi The relationships between low levels of urine fluoride on children's intelligence, dental fluorosis in endemic fluorosis areas in Hulunbuir, Inner Mongolia, China
    Yunpeng Ding
    Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang, China
    J Hazard Mater 186:1942-6. 2011
    ....
  76. ncbi Influence of carbamide peroxide on enamel fluoride uptake
    Thomas Attin
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, Georg August University Gottingen, D 37075 Gottingen, Germany
    J Dent 34:668-75. 2006
    ....
  77. ncbi Review of fluoride removal from drinking water
    M Mohapatra
    Institute of Minerals and Materials Technology, Bhubaneswar 751 013, Orissa, India
    J Environ Manage 91:67-77. 2009
    ..During the last few years, layered double oxides have been of interest as adsorbents for fluoride removal. Such recent developments have been briefly discussed...
  78. ncbi Fluoride intake and urinary excretion in 6- to 7-year-old children living in optimally, sub-optimally and non-fluoridated areas
    A Maguire
    School of Dental Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Community Dent Oral Epidemiol 35:479-88. 2007
    ..Subsidiary aims were to investigate the relationships between the variables measured...
  79. ncbi Fluoride intake by children at risk for the development of dental fluorosis: comparison of regular dentifrices and flavoured dentifrices for children
    M J L Oliveira
    Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Caries Res 41:460-6. 2007
    ..Moreover, the dose to which children were exposed with either type of dentifrice was very close to that which is considered the limit (0.05-0.07 mg F/kg/day)...
  80. pmc Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries
    H Koo
    Center for Oral Biology and Eastman Dept of Dentistry, University of Rochester Medical Center, 625 Elmwood Avenue, Box 683, Rochester, NY 14620, USA
    J Dent Res 84:1016-20. 2005
    ..Results from these studies showed that apigenin and tt-farnesol may enhance the cariostatic effectiveness of fluoride...
  81. ncbi (18)F-fluoride PET for monitoring therapeutic response in Paget's disease of bone
    Johanne Installé
    Department of Molecular Imaging and Experimental Radiotherapy, Catholic University of Louvain, Brussels, Belgium
    J Nucl Med 46:1650-8. 2005
    ..A prospective study was undertaken to evaluate PET with (18)F-fluoride for monitoring the response to bisphosphonates in Paget's disease of bones...
  82. ncbi Caries experience and background factors in 4-year-old children: time trends 1967-2002
    C Stecksen-Blicks
    Department of Odontology, Paediatric Dentistry, Umea University, Umea, Sweden
    Caries Res 38:149-55. 2004
    ..in northern Sweden, were examined for dental caries and background factors such as oral hygiene habits, use of fluorides, and sugar consumption. The same methods and criteria have been used in each of the studies from 1967 to 2002...
  83. ncbi Available fluoride in toothpastes used by Brazilian children
    Jaime Aparecido Cury
    Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil
    Braz Dent J 21:396-400. 2010
    ..3 to 1432.3 ppm F (mean ± SD of 1017.6 ± 239.4). These findings suggest that most dentifrices used by Brazilian children present available fluoride concentration for caries control...
  84. ncbi Fluoride intake and prevalence of dental fluorosis: trends in fluoride intake with special attention to infants
    S J Fomon
    Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242 1083, USA
    J Public Health Dent 60:131-9. 2000
    ..Dental fluorosis is closely associated with fluoride intake during the period of tooth development...
  85. ncbi Fluoride toxicity to aquatic organisms: a review
    Julio A Camargo
    Departamento Interuniversitario de Ecología, Edificio de Ciencias, Universidad de Alcala, Alcala de Henares, Madrid E 28871, Spain
    Chemosphere 50:251-64. 2003
    ..5 mg F-/l can adversely affect invertebrates and fishes, safe levels below this fluoride/l concentration are recommended in order to protect freshwater animals from fluoride pollution...
  86. pmc The impact of fluoride on ameloblasts and the mechanisms of enamel fluorosis
    A L J J Bronckers
    Department of Oral Cell Biology, ACTA, University of Amsterdam and VU University Amsterdam, Research Institute MOVE, Amsterdam, The Netherlands
    J Dent Res 88:877-93. 2009
    ..A new working model is presented, focused on the assumption that fluoride increases the rate of mineral formation, resulting in a greater release of protons into the forming enamel matrix...
  87. ncbi Sugar consumption and caries risk: a systematic review
    B A Burt
    University of Michigan, School of Public Health, Ann Arbor 48109 2029, USA
    J Dent Educ 65:1017-23. 2001
    ..Controlling the consumption of sugar remains a justifiable part of caries prevention, however, if not always the most important aspect...
  88. ncbi Review on fluoride, with special emphasis on calcium fluoride mechanisms in caries prevention
    J M Ten Cate
    Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam ACTA, The Netherlands
    Eur J Oral Sci 105:461-5. 1997
    ..Moreover, due to the phosphate groups on the surface of the calcium fluoride globules, fluoride is assumed to be released with decreasing pH when the phosphate groups are protonated in the dental plaque...
  89. ncbi Elevated fluoride products enhance remineralization of advanced enamel lesions
    J M Ten Cate
    Cariology Endodontology Pedodontology, Academic Center for Dentistry ACTA, Louwesweg 1, 1066 EA Amsterdam, The Netherlands
    J Dent Res 87:943-7. 2008
    ..With 5000-ppm-F treatments, more demineralizing episodes per day (10 vs. 2 for placebo) would still be repaired by remineralization...
  90. ncbi Review of fluoride exposures and ingestion
    S M Levy
    Department of Preventive and Community Dentistry, College of Dentistry, University of Iowa, Iowa City
    Community Dent Oral Epidemiol 22:173-80. 1994
    The literature on fluoride intake/ingestion was reviewed critically to determine the current exposure to fluorides for children living in non-fluoridated and fluoridated areas in North America...
  91. ncbi Current understanding of the epidemiology mechanisms, and prevention of dental caries in preschool children
    Norman Tinanoff
    Department of Pediatric Dentistry, Dental School, University of Maryland, Baltimore, USA
    Pediatr Dent 24:543-51. 2002
    ....
  92. ncbi Quantitative studies of bone with the use of 18F-fluoride and 99mTc-methylene diphosphonate
    G M Blake
    Department of Nuclear Medicine, Guy's Hospital, London, England
    Semin Nucl Med 31:28-49. 2001
    ..However, comparable data could probably be obtained by using 99mTc-MDP if methods for single photon emission computed tomography (SPECT) quantitation were improved...
  93. ncbi The water permeability of Arabidopsis plasma membrane is regulated by divalent cations and pH
    Patricia Gerbeau
    Biochimie et Physiologie Moleculaire des Plantes, Agro M INRA CNRS UM, 2 place Viala, F 34060 Montpellier Cedex, France
    Plant J 30:71-81. 2002
    ..2-7.5. Thus, both Ca2+ and H+ contribute to a membrane-delimited switch from active to inactive water channels that may allow coupling of water transport to cell signalling and metabolism...
  94. pmc Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element
    Andrea Scrima
    Max Planck Institut fur molekulare Physiologie, Dortmund, Germany
    EMBO J 25:2940-51. 2006
    ..We propose a model for the juxtaposition of G-domains in the full-length protein and how it induces conformational changes in the putative tRNA-modification centre...
  95. pmc Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion
    Ramaswamy Sharma
    Department of Cytokine Biology, Forsyth Institute, Boston, Massachusetts, USA
    Environ Health Perspect 116:1142-6. 2008
    ..The UPR is a signaling pathway responsible for either alleviating endoplasmic reticulum (ER) stress or for inducing apoptosis of the stressed cells...
  96. ncbi Medically administered antibiotics, dietary habits, fluoride intake and dental caries experience in the primary dentition
    Boipelo P Mariri
    Department of Preventive and Community Dentistry, College of Dentistry, 200 Hawkins Drive 01105 PFP, The University of Iowa, Iowa City, IA 52242, USA
    Community Dent Oral Epidemiol 31:40-51. 2003
    ..The purpose of this study was to assess factors related to extensive caries experience among children aged 4-7 years, including antibiotic use, dietary patterns, fluoride intakes, and tooth brushing habits...
  97. ncbi Susceptibility of enamel surfaces to demineralization after application of fluoridated carbamide peroxide gels
    T Attin
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, Georg August University Gottingen, Gottingen, Germany
    Caries Res 37:93-9. 2003
    ..Use of a fluoridated neutral gel decreases the degree of surface softening compared to the other gels investigated...
  98. ncbi The biochemistry and physiology of metallic fluoride: action, mechanism, and implications
    Liang Li
    Faculty of Dentistry, University of Manitoba, Winnipeg, MB, Canada
    Crit Rev Oral Biol Med 14:100-14. 2003
    ..The aim of this review is to discuss the basic chemical, biochemical, and toxicological properties of metallic fluoride, to explore its potential physiological and clinical implications...
  99. ncbi A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice
    Giovanna Orsini
    Department of Clinical Sciences and Stomatology, Polytechnique University of Marche, Ancona, Italy
    J Clin Periodontol 37:510-7. 2010
    ..The aim of the study was to evaluate the desensitizing efficacy of a new dentifrice based on zinc-carbonate hydroxyapatite (CHA) nanocrystals...
  100. ncbi Fluoride uptake, retention, and remineralization efficacy of a highly concentrated fluoride solution on enamel lesions in situ
    W Buchalla
    Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN, USA
    J Dent Res 81:329-33. 2002
    Repeated topical application of concentrated fluorides is known to reduce caries. Little is known about fluoride retention and remineralization in incipient caries lesions following a single application...
  101. pmc Bone metabolic activity in hyperostosis cranialis interna measured with 18F-fluoride PET
    Jérôme J Waterval
    Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, PO 5800, 6202 AZ Maastricht, The Netherlands
    Eur J Nucl Med Mol Imaging 38:884-93. 2011
    ..The aim of this study is to compare standardised uptake values (SUVs) at different sites in order to quantify bone metabolism in the affected anatomical regions in HCI patients...

Research Grants66

  1. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    ....
  2. Dietary patterns and root caries risk
    ELIZABETH A KAYE; Fiscal Year: 2010
    ..The findings may help to define healthy eating patterns that reduce the risk of root decay. ..
  3. Biomaterials (Mf/Zn/F-BCPs) for osteoporosis therapy
    Yu Zhang; Fiscal Year: 2012
    ..These results will greatly impact public health and alleviate the tremendous socio- economic burden associated with osteoporosis. ..
  4. Dental Caries: Whole Genome Association and Gene x Environment Studies
    Mary L Marazita; Fiscal Year: 2010
    ..Successful completion of this study will allow a better understanding of the biology of dental caries, and will lead to earlier identification of children at risk for dental caries, thereby allowing improved and targeted interventions. ..
  5. Genetic Determinants of Physiological Responses to Fluoride in Bone
    Eric T Everett; Fiscal Year: 2012
    ..This animal studies project will generate interpretable and useful information relevant to public health issues like osteoporosis and skeletal fluorosis. ..
  6. Making a quantum leap in plaque research with modern sciences
    Wenyuan Shi; Fiscal Year: 2013
    ....
  7. Northwest/Alaska/Hawaii Center to Reduce Oral Health Disparities
    PETER M MILGROM; Fiscal Year: 2012
    ..abstract_text> ..
  8. Oxidative Stress in Oral Streptococci
    Robert E Marquis; Fiscal Year: 2010
    ..The work involves basic and applied studies Aimed at a better understanding of the biology of Dental plaque bacteria related especially to oxygen metabolism and damage caused by reactive oxygen species. ..
  9. Center for Native Oral Health Research (CNOHR)
    Judith E N Albino; Fiscal Year: 2013
    ....
  10. Biosynthesis & Function of a Bacillus anthracis-specific cell wall polysaccharide
    Russell W Carlson; Fiscal Year: 2010
    ..This investigation will lay the groundwork for future studies into improved vaccines, diagnostics, and therapeutics, and into new anthrax-related public health practices. ..
  11. Fluoride &Other Factors in Childhood and Adolescent Bone Development
    Steven M Levy; Fiscal Year: 2013
    ..abstract_text> ..
  12. Structural basis of mRNA decapping by Dcp2: conformational changes &co-activator
    JEFFREY SCOTT MUGRIDGE; Fiscal Year: 2013
    ..These studies will provide a molecular level understanding of how protein-protein interactions and conformational changes in the conserved decapping enzyme Dcp2 control mRNA cap cleavage and thus help regulate transcript stability. ..
  13. Prevention of Dental Caries in Early Head Start Children
    RICHARD GARY ROZIER; Fiscal Year: 2012
    ..The result of successful implementation of preventive dental programs should be less disease and improved quality of life among children and their families. ..
  14. Modeling Adherence to Swallowing and Dental Regimens in Head and Neck Cancer
    Eileen H Shinn; Fiscal Year: 2010
    ....
  15. The Role of Stress and pH in Fluorosis
    John D Bartlett; Fiscal Year: 2013
    ..Completion of this study will provide a defined F--induced molecular pathway and will identify stress genes that protect cells from F-. ..
  16. Novel Antibacterial Fluoride-releasing Dental Materials
    Xiaoming Xu; Fiscal Year: 2012
    ..3) The combined use of an antibacterial fluoride-releasing composite, bonding agent and bioactive sealant will further reduce caries. ..
  17. Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients
    Rajesh V Lalla; Fiscal Year: 2013
    ....
  18. New Methods for the Expedited Synthesis of C11 and F18 PET Tracers
    Salvatore D Lepore; Fiscal Year: 2013
    ....
  19. Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutans
    Hyun Koo; Fiscal Year: 2012
    ..Our approach uses natural compounds, is highly effective without suppressing the resident oral flora (non-microbiocidal) and may decrease exposure to fluoride. ..
  20. Trehalose-6-phosphate phosphatase: a target for anti-onchocerciasis therapeutics
    Debra Dunaway-Mariano; Fiscal Year: 2013
    ..This work will deliver the foundation for the development of a drug for the treatment of disease(s) inflicting the large segment of the world's population suffering from infection by parasitic nematodes. ..
  21. Developing Inhibitors of Superoxide Dismutase Enzymes
    Jack S Summers; Fiscal Year: 2010
    ..Survival of invasive bacteria and cancerous cells are each highly dependent on the SOD enzymes that we intend to target. ..
  22. Scientific Basis of Iodine-Fluoride Varnish in Preventing Dental Caries
    R MIKE SHIRTCLIFF; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Topical fluorides have been the mainstay in the prevention of dental caries for decades. However, topical fluoride alone is not enough to thwart tooth decay in high-risk populations...
  23. Synthesis of Radiofluorinated PET Imaging Agents
    STEPHEN DIMAGNO; Fiscal Year: 2013
    ..The proposed work will build on a foundation of mechanistic studies describing the high yield formation of aryl fluorides from the reductive elimination of diaryliodonium fluoride salts...
  24. The Role of Iron in Ameloblast Differentiation and Enamel Fluorosis
    Michael Le; Fiscal Year: 2013
    ....
  25. Innovation in the Prevention and Treatment of Early Childhood Caries
    Norman Tinanoff; Fiscal Year: 2013
    ....
  26. Prenatal and Childhood Exposure to Fluoride and Neurodevelopment
    Howard Hu; Fiscal Year: 2013
    ..Given the power of our archived resources and sample sizes, we will be able to accomplish this research at a small fraction of the cost and time required of a new study. ..
  27. PREVENT TRANSMIS OF MUTANS STREPTOC FR MOTHER TO CHILD
    Walter Bretz; Fiscal Year: 2004
    ..reduced in mothers of young infants by an intervention program which may include restorative procedures, topical fluorides, the use of xylitol chewing gum, and chlorhexidine varnishes; 2) to determine whether this intervention reduces ..
  28. Role of Microstructure in Nanomechanical Behavior of Bone Tissue
    Marjolein C van der Meulen; Fiscal Year: 2010
    ..Our approach will cross-correlate several microlevel techniques that have not been previously used to characterize bone tissue mechanics. ..
  29. ENAMEL FLUOROSIS: MECHANISMS OF ACTION
    Pamela K Den Besten; Fiscal Year: 2013
    ....
  30. Fluoride Effectiveness in Prevention of Dental Caries in High Caries Risk Adults
    JUDITH A JONES AKA FITZMAURICE; Fiscal Year: 2010
    ..The purpose of this study is to examine the effects of prescription strength, self-applied, brush on fluorides and in-office fluoride treatments in preventing decay in a real-world setting of medically compromised older ..
  31. Shape Shifting Phosphines in Transition Metal Catalysis
    THOMAS JOHN MAIMONE; Fiscal Year: 2012
    ..The metal-catalyzed synthesis of aryl fluorides using Pd(0)/Pd(ll) catalysis has proven difficult to date...
  32. Evaluation of a low-fluoride anticaries toothpaste containing an innovative calci
    Robert L Karlinsey; Fiscal Year: 2010
    ..Such a formulation would be targeted specifically for children and adults as a safe and effective alternative to create significant value and provide a significant public health benefit. ..
  33. Laboratory and clinical evaluation of prospective fluoride rinses containing TCP-
    Robert L Karlinsey; Fiscal Year: 2012
    ....
  34. Examination of Oral Health Literacy in Public Health Practice
    Jessica Y Lee; Fiscal Year: 2013
    ....
  35. Training Oral Hygiene Habits with a Game
    DOV JACOBSON; Fiscal Year: 2011
    ..This misery can be prevented with a toothbrush - if good skills and motivation are taught. Some parents do not teach these. Can children learn them from a videogame? ..
  36. Center for Research to Evaluate &Eliminate Dental Disparities
    Raul I Garcia; Fiscal Year: 2013
    ..abstract_text> ..
  37. Center to Address Disparities in Children's Oral Health
    Stuart A Gansky; Fiscal Year: 2013
    ..These endeavors, with other education and career development activities, will foster new investigators to increase oral-health-disparity research capacity. ..
  38. Clinical Research and Mentoring in Oral Epidemiology
    Kaumudi Joshipura; Fiscal Year: 2009
    ..Budget: No concerns ..
  39. Contra Caries: Preventing ECC Using a Promotora Model for Rural Latino Families
    Judith C Barker; Fiscal Year: 2010
    ..The intervention enhances parents'ability to assist and better manage children's oral health care behaviors. ..
  40. Chemo-enzymatic Approach to Late-stage Aromatic Fluorination of Drug Scaffolds
    RYAN MARK LAUCHLI; Fiscal Year: 2012
    ..This enzymatic step will be followed by chemical transformation of the resulting phenols to aryl fluorides using, and improving upon, recently developed chemistry...
  41. Development of Dopamine D1 Receptor Agonists for PET Imaging
    Balasubramaniam Easwaramoorthy; Fiscal Year: 2012
    ..In this project, we propose to develop D1R agonist PET ligands to allow in vivo investigation of the functional state of the receptor. ..
  42. Multifunctional, Non-thermal Plasmas for Long-lasting Dental Adhesion
    Qingsong Yu; Fiscal Year: 2013
    ..The goal is not only to confirm that the design principles and the engineered plasma technology/chemistries work, but also gain deep understanding into how and why they do. ..
  43. Clinical Assessment of Tooth Demineralization &Remineralization with PS-OCT
    Daniel Fried; Fiscal Year: 2013
    ....
  44. Dentin Fluoride as a Biomarker for Childhood Fluoride Intake
    JAMES STERN WEFEL; Fiscal Year: 2010
    ....
  45. Early Caries Detection with Near-IR Light
    Daniel Fried; Fiscal Year: 2013
    ....
  46. Investigating Mechanisms of Fluoride Sensing and Toxicity Mitigation in Bacteria
    Ronald R Breaker; Fiscal Year: 2013
    ..This knowledge will help assess the long-standing hypothesis that the antibacterial activity of fluoride contributes to the prevention of dental caries. ..
  47. Investigations of New Pd"/Pd"-catalyzed aryl C-F and C-CF3 Coupling Reactions
    NICHOLAS DEWAYNE BALL; Fiscal Year: 2010
    ..The Pd-catalyzed aryl C-F bond forming methodology will exploit the relative reactivity of Pd(ll) fluorides compared to aryl Pd(ll) species in the presence of electophilic fluorinating reagents...
  48. CARBONATOAPATITE FORMATION IN ENAMEL MINERALIZATION
    Takaaki Aoba; Fiscal Year: 1993
    ..The information obtained is valuable to predict the stability of dental enamel in normal and cariogenic environments or under fluoride regimes...
  49. Optical Assessment of Caries Lesion Structure and Activity
    ROBERT CHULSUNG LEE; Fiscal Year: 2013
    ....
  50. Effects of Natural Agents with Fluoride on Caries
    Hyun Koo; Fiscal Year: 2004
    ....
  51. NANOSTRUCTURED BIOACTIVE MATERIALS
    Laurence Chow; Fiscal Year: 2009
    ..Aim 3 will evaluate the effectiveness of nano sized calcium phosphates and calcium fluoride in reducing dentin permeability, a property closely associated with dental hypersensitivity. ..
  52. Effects of Biofilm Activities and Dental Resin Composite Compositions on the Deve
    Clifton M Carey; Fiscal Year: 2013
    ..With this understanding, we will develop more stable resin-based composites and methods to prevent the decay that limits the success of composite restorations. ..
  53. University of Iowa Institutional Training Program in Oral Health Research
    Christopher Squier; Fiscal Year: 2013
    ..Public Health Relevance Statement Page 8 ..
  54. NOVEL STATISTICAL MODELS FOR DENTAL CARIES
    Somnath Datta; Fiscal Year: 2013
    ..We will compare our results to those obtained from existing approaches. Statistical software (R packages/codes) for the novel data analysis methods will be freely distributed through the Comprehensive R Archive Network. ..
  55. Integrated Microfluidic Devices for 18F Labeled PET Probes in Cancer Imaging
    Hsian Rong Tseng; Fiscal Year: 2010
    ..The long term objective of this proposal is to make [18F]-labeled PET probes easily accessible so that researchers and clinicians can perform a wide range of PET studies targeting specific molecular lesions in cancer. ..
  56. Rank tests for clustered data with potentially informative cluster size: Novel st
    Somnath Datta; Fiscal Year: 2012
    ....
  57. EFFECT OF DIETARY METHYLXANTHINES ON FLUORIDE METABOLISM
    JARVIS CHAN; Fiscal Year: 1990
    ..Above all, information obtained here could lead to a direct clinical application in prevention of dental caries, dental fluorosis and treatment of osteoporosis..
  58. LONGITUDINAL SUCKING PATTERNS & DENTAL ARCH DEVELOPMENT
    John Warren; Fiscal Year: 2000
    ..abstract_text> ..
  59. University of Iowa Institutional Training Program in Oral Health Research
    Christopher Squier; Fiscal Year: 2013
    ..The outcome will be the development of a cadre of oral health researchers equipped to function at the cutting edge of their disciplines. ..
  60. FLUORIDE EXPOSURES IN YOUNG CHILDREN-LONGITUDINAL PILOT
    Steven Levy; Fiscal Year: 1990
    ..relationships could be investigated between prevalence and severity of dental fluorosis and the various fluoride exposures in an effort to balance the optimal use of fluorides for caries prevention with risks of dental fluorosis.
  61. INFLUENCE OF ACID-BASE STATUS ON FLUORIDE METABOLISM
    GARY WHITFORD; Fiscal Year: 1992
    ....
  62. NORMAL & PATHOLOGICAL ENAMEL MINERALIZATION
    Takaaki Aoba; Fiscal Year: 1993
    ....
  63. Site-Specific Non-Mutans Streptococci Etiologies of Dental Caries
    Jeffrey A Banas; Fiscal Year: 2013
    ..The study design will allow longitudinal and cross-sectional data analyses that represent a unique approach to testing this important hypothesis. ..
  64. X-RAY MICROANALYTICAL STUDY OF FLUORIDE DISTRIBUTION
    JOSEPH GLAWSON; Fiscal Year: 1990
    ..These studies will provide significant new information on the content and distribution of fluoride and other elements in the study of caries prevalence and prevention...
  65. Dental Caries Traits: The Genetic Contribution
    Walter Bretz; Fiscal Year: 2007
    ..In addition, they have no access to fluoridated water or professionally administered topical fluorides. The primary goal of this proposal is to determine, in cross-sectional and prospective data, the relative ..
  66. Organometallic Chemistry for Applications in Biomedical Sciences
    Tobias Ritter; Fiscal Year: 2013
    ..The current inability of chemists to efficiently make complex organic fluorides by late-stage fluorination often prevents research in diverse areas, such as drug development and molecular PET ..