phosphorus

Summary

Summary: An element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element in the diet, a major component of the mineral phase of bone, and is abundant in all tissues, being involved in some form in almost all metabolic processes. (From Dorland, 27th ed)

Top Publications

  1. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
  2. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
  3. pmc An RNA-Seq transcriptome analysis of orthophosphate-deficient white lupin reveals novel insights into phosphorus acclimation in plants
    Jamie A O'Rourke
    United States Department of Agriculture Agricultural Research Service, Plant Science Research Unit, St Paul, Minnesota 55108, USA
    Plant Physiol 161:705-24. 2013
  4. ncbi Global analysis of nitrogen and phosphorus limitation of primary producers in freshwater, marine and terrestrial ecosystems
    James J Elser
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Ecol Lett 10:1135-42. 2007
  5. doi Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis
    Suetonia C Palmer
    Department of Medicine, University of Otago, Christchurch, New Zealand
    JAMA 305:1119-27. 2011
  6. doi Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Francesca Tentori
    Arbor Research Collaborative for Health, University of Michigan, Ann Arbor, MI 48103, USA
    Am J Kidney Dis 52:519-30. 2008
  7. doi Phytoplankton in the ocean use non-phosphorus lipids in response to phosphorus scarcity
    Benjamin A S van Mooy
    Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    Nature 458:69-72. 2009
  8. ncbi Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients
    K Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Kidney Int 70:771-80. 2006
  9. doi Root developmental adaptation to phosphate starvation: better safe than sorry
    Benjamin Peret
    UMR 6191 CEA, Centre National de la Recherche Scientifique, Laboratoire de Biologie du Développement des Plantes, Universite d Aix Marseille, 13108 Saint Paul Lez Durance, France
    Trends Plant Sci 16:442-50. 2011
  10. pmc Identification of nutrient-responsive Arabidopsis and rapeseed microRNAs by comprehensive real-time polymerase chain reaction profiling and small RNA sequencing
    Bikram Datt Pant
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam, Germany
    Plant Physiol 150:1541-55. 2009

Detail Information

Publications327 found, 100 shown here

  1. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
    ..in hemodialysis patients, data on 40,538 hemodialysis patients with at least one determination of serum phosphorus and calcium during the last 3 mo of 1997 were analyzed...
  2. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
    ....
  3. pmc An RNA-Seq transcriptome analysis of orthophosphate-deficient white lupin reveals novel insights into phosphorus acclimation in plants
    Jamie A O'Rourke
    United States Department of Agriculture Agricultural Research Service, Plant Science Research Unit, St Paul, Minnesota 55108, USA
    Plant Physiol 161:705-24. 2013
    b>Phosphorus, in its orthophosphate form (P(i)), is one of the most limiting macronutrients in soils for plant growth and development...
  4. ncbi Global analysis of nitrogen and phosphorus limitation of primary producers in freshwater, marine and terrestrial ecosystems
    James J Elser
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Ecol Lett 10:1135-42. 2007
    The cycles of the key nutrient elements nitrogen (N) and phosphorus (P) have been massively altered by anthropogenic activities...
  5. doi Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis
    Suetonia C Palmer
    Department of Medicine, University of Otago, Christchurch, New Zealand
    JAMA 305:1119-27. 2011
    Clinical practice guidelines on the management of mineral and bone disorders due to chronic kidney disease recommend specific treatment target levels for serum phosphorus, parathyroid hormone, and calcium.
  6. doi Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Francesca Tentori
    Arbor Research Collaborative for Health, University of Michigan, Ann Arbor, MI 48103, USA
    Am J Kidney Dis 52:519-30. 2008
    Abnormalities in serum calcium, phosphorus, and parathyroid hormone (PTH) concentrations are common in patients with chronic kidney disease and have been associated with increased morbidity and mortality...
  7. doi Phytoplankton in the ocean use non-phosphorus lipids in response to phosphorus scarcity
    Benjamin A S van Mooy
    Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    Nature 458:69-72. 2009
    b>Phosphorus is an obligate requirement for the growth of all organisms; major biochemical reservoirs of phosphorus in marine plankton include nucleic acids and phospholipids...
  8. ncbi Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients
    K Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Kidney Int 70:771-80. 2006
    ..Changes in baseline calcium and phosphorus values beyond the Kidney Disease Outcome Quality Initiative recommended targets were associated with increased ..
  9. doi Root developmental adaptation to phosphate starvation: better safe than sorry
    Benjamin Peret
    UMR 6191 CEA, Centre National de la Recherche Scientifique, Laboratoire de Biologie du Développement des Plantes, Universite d Aix Marseille, 13108 Saint Paul Lez Durance, France
    Trends Plant Sci 16:442-50. 2011
    b>Phosphorus is a crucial component of major organic molecules such as nucleic acids, ATP and membrane phospholipids. It is present in soils in the form of inorganic phosphate (Pi), which has low availability and poor mobility...
  10. pmc Identification of nutrient-responsive Arabidopsis and rapeseed microRNAs by comprehensive real-time polymerase chain reaction profiling and small RNA sequencing
    Bikram Datt Pant
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam, Germany
    Plant Physiol 150:1541-55. 2009
    ..The platform was used to detect phosphorus (P) or nitrogen (N) status-responsive pri-miR species...
  11. ncbi Java-based graphical user interface for the MRUI quantitation package
    A Naressi
    , , , Leipzig, Germany
    MAGMA 12:141-52. 2001
    ..This new graphical user interface (GUI) has been conceived for the processing of large data sets and uses prior knowledge data-bases to make interactive quantitation algorithms more userfriendly...
  12. pmc Plasma fibroblast growth factor 23, parathyroid hormone, phosphorus, and risk of coronary heart disease
    Eric N Taylor
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am Heart J 161:956-62. 2011
    Fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and phosphorus all have been proposed as plasma biomarkers for the development of coronary heart disease (CHD) in individuals with normal renal function.
  13. pmc Developing rice with high yield under phosphorus deficiency: Pup1 sequence to application
    Joong Hyoun Chin
    International Rice Research Institute, Plant Breeding, Genetics, and Biotechnology Division, 7777 Metro Manila, Philippines
    Plant Physiol 156:1202-16. 2011
    The major quantitative trait locus (QTL) Phosphorus uptake1 (Pup1) confers tolerance of phosphorus deficiency in soil and is currently one of the most promising QTLs for the development of tolerant rice (Oryza sativa) varieties...
  14. doi Reciprocal rewards stabilize cooperation in the mycorrhizal symbiosis
    E Toby Kiers
    Institute of Ecological Science, Vrije Universiteit, 1081 HV Amsterdam, Netherlands
    Science 333:880-2. 2011
    ..Rather, the mutualism is evolutionarily stable because control is bidirectional, and partners offering the best rate of exchange are rewarded...
  15. pmc Serum phosphorus concentrations in the third National Health and Nutrition Examination Survey (NHANES III)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98104 2499, USA
    Am J Kidney Dis 53:399-407. 2009
    Higher serum phosphorus concentrations within the normal laboratory range have been associated with cardiovascular events and mortality in large prospective cohort studies of individuals with and without kidney disease...
  16. doi River loads of suspended solids, nitrogen, phosphorus and herbicides delivered to the Great Barrier Reef lagoon
    Frederieke J Kroon
    CSIRO Ecosystem Sciences, P O Box 780, Atherton, QLD 4883, Australia
    Mar Pollut Bull 65:167-81. 2012
    ..5 times to 17,000ktonnes/year, (ii) total nitrogen by 5.7 times to 80,000tonnes/year, (iii) total phosphorus by 8.9 times to 16,000tonnes/year, and (iv) PSII herbicides is 30,000kg/year...
  17. doi Nitrogen inputs accelerate phosphorus cycling rates across a wide variety of terrestrial ecosystems
    Alison R Marklein
    Department of Land, Air, and Water Resources, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    New Phytol 193:696-704. 2012
    Biologically essential elements--especially nitrogen (N) and phosphorus (P)--constrain plant growth and microbial functioning; however, human activities are drastically altering the magnitude and pattern of such nutrient limitations ..
  18. pmc Identification and characterization of the Arabidopsis PHO1 gene involved in phosphate loading to the xylem
    Dirk Hamburger
    Institut d Ecologie Biologie et Physiologie Végétales, Batiment de Biologie, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Plant Cell 14:889-902. 2002
    ..The Arabidopsis genome contains 10 additional genes showing homology with PHO1. Thus, PHO1 defines a novel class of proteins involved in ion transport in plants...
  19. ncbi Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Arch Intern Med 167:879-85. 2007
    Higher levels of serum phosphorus and the calcium-phosphorus product are associated with increased mortality from cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) or prior CVD...
  20. ncbi Predictors and consequences of altered mineral metabolism: the Dialysis Outcomes and Practice Patterns Study
    Eric W Young
    Department of Veterans Affairs Medical Center, and Division of Nephrology, University of Michigan, Ann Arbor, Michigan, USA
    Kidney Int 67:1179-87. 2005
    ..Altered mineral metabolism contributes to bone disease, cardiovascular disease, and other clinical problems in patients with end-stage renal disease...
  21. ncbi Nitrogen deficiency as well as phosphorus deficiency in sorghum promotes the production and exudation of 5-deoxystrigol, the host recognition signal for arbuscular mycorrhizal fungi and root parasites
    Kaori Yoneyama
    Weed Science Center, Utsunomiya University, 350 Mine machi, Utsunomiya, Japan
    Planta 227:125-32. 2007
    ..a host for both AM fungi and the root holoparasitic plant Orobanche minor Sm., reduced supply of phosphorus (P) but not of other elements examined (N, K, Ca, Mg) in the culture medium significantly promoted the secretion ..
  22. ncbi Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
    ..target the calcium-sensing receptor and lower parathyroid hormone levels without increasing calcium and phosphorus levels...
  23. pmc The role of phosphorus in the development and progression of vascular calcification
    Jessica Kendrick
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA
    Am J Kidney Dis 58:826-34. 2011
    ..This review discusses these mechanisms in depth, exploring the interplay among vascular calcification promoters, inhibitors, and substrate that affect phosphorus handling leading to vascular calcification in individuals with CKD.
  24. pmc Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study
    ORLANDO M GUTIERREZ
    Division of Nephrology, Department of Medicine, and Department of Epidemiology, University of Alabama at Birmingham, AL, USA
    Clin J Am Soc Nephrol 6:2871-8. 2011
    Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism...
  25. doi Opportunities for improving phosphorus-use efficiency in crop plants
    Erik J Veneklaas
    School of Plant Biology, The University of Western Australia, Crawley, WA 6009, Australia
    New Phytol 195:306-20. 2012
    Limitation of grain crop productivity by phosphorus (P) is widespread and will probably increase in the future...
  26. ncbi Mapping of QTLs for lateral root branching and length in maize (Zea mays L.) under differential phosphorus supply
    Jinming Zhu
    Department of Horticulture, Pennsylvania State University, University Park, PA 16802, USA
    Theor Appl Genet 111:688-95. 2005
    Low phosphorus availability is a primary constraint for plant growth in terrestrial ecosystems...
  27. pmc How do nitrogen and phosphorus deficiencies affect strigolactone production and exudation?
    Kaori Yoneyama
    Weed Science Center, Utsunomiya University, 350 Mine machi, Utsunomiya 321 8505, Japan
    Planta 235:1197-207. 2012
    ..Previous studies have demonstrated that phosphorus (P) deficiency, but not nitrogen (N) deficiency, significantly promotes SL exudation in red clover, while in ..
  28. ncbi Iron and phosphorus co-limit nitrogen fixation in the eastern tropical North Atlantic
    Matthew M Mills
    Marine Biogeochemistry, IFM GEOMAR Leibniz Institut für Meereswissenschaften, Düsternbrooker Weg 20, D 24105 Kiel, Germany
    Nature 429:292-4. 2004
    ..nitrogen fixation and hence oceanic primary productivity on geological timescales, providing an alternative to phosphorus as the ultimate limiting nutrient...
  29. ncbi Potassium, phosphorus, or nitrogen limit root allocation, tree growth, or litter production in a lowland tropical forest
    S Joseph Wright
    Smithsonian Tropical Research Institute, Apartado 0843 03092, Balboa, Republic of Panama
    Ecology 92:1616-25. 2011
    We maintained a factorial nitrogen (N), phosphorus (P), and potassium (K) addition experiment for 11 years in a humid lowland forest growing on a relatively fertile soil in Panama to evaluate potential nutrient limitation of tree growth ..
  30. ncbi How do plants respond to nutrient shortage by biomass allocation?
    Christian Hermans
    Laboratoire de Physiologie et de Génétique Moléculaire des Plantes, Universite Libre de Bruxelles, Boulevard du Triomphe CP 242, 1050 Brussels, Belgium
    Trends Plant Sci 11:610-7. 2006
    ..It has long been known that deficiencies of essential macronutrients (nitrogen, phosphorus, potassium and magnesium) result in an accumulation of carbohydrates in leaves and roots, and modify the shoot-..
  31. doi Systematic review of the evidence underlying the association between mineral metabolism disturbances and risk of all-cause mortality, cardiovascular mortality and cardiovascular events in chronic kidney disease
    Adrian Covic
    Dialysis and Renal Transplantation Center, C I Parhon University Hospital and University of Medicine Gr T Popa Iasi, Blvd Carol I Nr 50, Iasi, 700503, Romania
    Nephrol Dial Transplant 24:1506-23. 2009
    ..Thus, a systematic review was conducted to assess methodological and clinical heterogeneity by comparing designs, analytical approaches and results of studies...
  32. ncbi Effect of nitrogen and phosphorus on growth of toxic and nontoxic Microcystis strains and on intracellular microcystin concentrations
    C Vezie
    Department of Applied Chemistry and Microbiology, Division of Microbiology, Biocenter Viikki, FIN 00014 Helsinki University, Finland
    Microb Ecol 43:443-54. 2002
    ..84-84 mg L(-1)) and phosphorus (0.05-5.5 mg L(-1)) concentrations...
  33. pmc Dietary phosphorus acutely impairs endothelial function
    Emi Shuto
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    J Am Soc Nephrol 20:1504-12. 2009
    Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well as in patients with chronic kidney disease, but the mechanisms underlying this risk are not completely understood...
  34. ncbi Phosphorus deficiency in red clover promotes exudation of orobanchol, the signal for mycorrhizal symbionts and germination stimulant for root parasites
    Kaori Yoneyama
    United Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu 183 8509, Japan
    Planta 225:1031-8. 2007
    ..reduced supply of phosphorus (P) but not of other elements examined (N, K, Mg, Ca) in the culture medium significantly promotes the release ..
  35. ncbi The oceanic phosphorus cycle
    Adina Paytan
    Department of Geological and Environmental Sciences, Stanford University, Stanford, California 94305 2115, USA
    Chem Rev 107:563-76. 2007
  36. doi Sucrose transport in the phloem: integrating root responses to phosphorus starvation
    John P Hammond
    Warwick HRI, University of Warwick, Wellesbourne, Warwick CV35 9EF, UK
    J Exp Bot 59:93-109. 2008
    ..Photosynthate is primarily transported to sink tissues as sucrose via the phloem. Under phosphorus (P) starvation, plants accumulate sugars and starch in their leaves...
  37. doi Capturing the lost phosphorus
    Bruce E Rittmann
    Swette Center for Environmental Biotechnology, Biodesign Institute at Arizona State University, PO Box 875701, Tempe, AZ 85287 5701, USA
    Chemosphere 84:846-53. 2011
    Minable phosphorus (P) reserves are being depleted and will need to be replaced by recovering P that currently is lost from the agricultural system, causing water-quality problems...
  38. doi The protein kinase Pstol1 from traditional rice confers tolerance of phosphorus deficiency
    Rico Gamuyao
    International Rice Research Institute, DAPO Box 7777 Metro, Manila 1301, Philippines
    Nature 488:535-9. 2012
    As an essential macroelement for all living cells, phosphorus is indispensable in agricultural production systems. Natural phosphorus reserves are limited, and it is therefore important to develop phosphorus-efficient crops...
  39. ncbi Forecasting agriculturally driven global environmental change
    D Tilman
    Department of Ecology, Evolution and Behavior, University of Minnesota, 1987 Upper Buford Circle, St Paul, MN 55108, USA
    Science 292:281-4. 2001
    ..This would be accompanied by 2.4- to 2.7-fold increases in nitrogen- and phosphorus-driven eutrophication of terrestrial, freshwater, and near-shore marine ecosystems, and comparable increases in ..
  40. doi Synthesis of phosphorus-doped graphene and its multifunctional applications for oxygen reduction reaction and lithium ion batteries
    Chenzhen Zhang
    Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China
    Adv Mater 25:4932-7. 2013
    We develop a simple and economical thermal annealing method for the synthesis of phosphorus-doped graphene, which exhibits remarkable electrocatalytic activity towards the oxygen reduction reaction and enhances the electrochemical ..
  41. pmc Global transcriptional responses of the toxic cyanobacterium, Microcystis aeruginosa, to nitrogen stress, phosphorus stress, and growth on organic matter
    Matthew J Harke
    School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, New York, USA
    PLoS ONE 8:e69834. 2013
    ..during growth with low levels of dissolved inorganic nitrogen (low N), low levels of dissolved inorganic phosphorus (low P), and in the presence of high levels of high molecular weight dissolved organic matter (HMWDOM)...
  42. pmc Phosphorus binders and survival on hemodialysis
    Tamara Isakova
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:388-96. 2009
    Although hyperphosphatemia is a risk factor for mortality, there are limited data on whether therapy with phosphorus binders affects survival...
  43. doi Bioengineering and management for efficient phosphorus utilization in crops and pastures
    Jiang Tian
    State Key Laboratory for Conservation and Utilization of Subtropical Agro bioresources, Root Biology Center, South China Agricultural University, Guangzhou 510642, China
    Curr Opin Biotechnol 23:866-71. 2012
    b>Phosphorus (P) is one of the three macronutrients for plants. Because of its low mobility and high fixation in soils, low P availability is a worldwide constraint for crop productivity...
  44. ncbi Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease
    Vladimir Mlynarik
    Ecole Polytechnique Federale de Lausanne, Laboratory of Functional and Metabolic Imaging LIFMET, Lausanne, Switzerland
    J Alzheimers Dis 31:S87-99. 2012
    ..In this report, we studied a new transgenic mouse model of AD, the 5xFAD model, by in vivo proton and phosphorus MR spectroscopy...
  45. ncbi Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in hemodialysis patients: the USRDS waves 1, 3, and 4 study
    Yelena Slinin
    United States Renal Data System Coordinating Center, 914 South 8th Street, Suite D 253, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 16:1788-93. 2005
    Animal studies suggest that calcium-phosphorus homeostatic abnormalities cause cardiovascular disease in uremia; few observational studies in humans have explored this...
  46. doi Nutrient limitation on terrestrial plant growth--modeling the interaction between nitrogen and phosphorus
    Göran I Agren
    Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    New Phytol 194:953-60. 2012
    ..However, the further the supply ratio deviates from these supply rates, the more the plants will follow the law of the minimum. Liebig's law of the minimum will in many cases be a useful first-order approximation...
  47. doi Serum calcium, phosphorus and cardiovascular events in post-menopausal women
    Yelena Slinin
    Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, United States
    Int J Cardiol 149:335-40. 2011
    There is increasing evidence linking phosphorus and calcium levels to a higher risk of cardiovascular morbidity and mortality in the general population.
  48. pmc Chronic kidney disease progression and outcome according to serum phosphorus in mild-to-moderate kidney dysfunction
    Antonio Bellasi
    Nephrology Dialysis Hypertension Unit, Policlinico S Orsola Malpighi, Via P Palagi 9, 40138 Bologna, Italy
    Clin J Am Soc Nephrol 6:883-91. 2011
    ..However, whether and to what extent hyperphosphatemia is associated with a poor prognosis in different CKD patient groups remain to be elucidated...
  49. doi Towards global phosphorus security: a systems framework for phosphorus recovery and reuse options
    D Cordell
    Institute for Sustainable Futures, University of Technology, Sydney, PO Box 123, Broadway, NSW 2007, Australia
    Chemosphere 84:747-58. 2011
    Human intervention in the global phosphorus cycle has mobilised nearly half a billion tonnes of the element from phosphate rock into the hydrosphere over the past half century...
  50. pmc Contrasting arbuscular mycorrhizal communities colonizing different host plants show a similar response to a soil phosphorus concentration gradient
    Paul Gosling
    HGCA, Stoneleigh Park, Kenilworth, Warwickshire, CV8 2TL, UK
    New Phytol 198:546-56. 2013
    High soil phosphorus (P) concentration is frequently shown to reduce root colonization by arbuscular mycorrhizal (AM) fungi, but the influence of P on the diversity of colonizing AM fungi is uncertain...
  51. doi High phosphorus diet induces vascular calcification, a related decrease in bone mass and changes in the aortic gene expression
    Pablo Román-García
    Bone and Mineral Research Unit Hospital Universitario Central de Asturias Instituto Reina Sofía de Investigación, REDinREN del ISCIII, Universidad de Oviedo Oviedo, Asturias, Spain
    Bone 46:121-8. 2010
    ..Our aim was to prospectively study the effects of high phosphorus diet on bone mass, vascular calcification and gene expression profile of the arterial wall...
  52. doi Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients
    Poyyapakkam R Srivaths
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX, 77030, USA
    Pediatr Nephrol 26:945-51. 2011
    ..of adult chronic hemodialysis (HD) patients is associated with coronary calcifications (CC), increased serum phosphorus (P), use of calcium (Ca)-containing P-binders, and vitamin D deficiency...
  53. ncbi Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review
    Graham J Kemp
    Division of Metabolic and Cellular Medicine, Faculty of Medicine, University of Liverpool, Liverpool, UK
    NMR Biomed 20:555-65. 2007
    ..e. from measured PCr/ATP and Pi/ATP ratios, assuming a literature value for [ATP])...
  54. doi Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition study
    A A Welch
    Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 63:S101-21. 2009
    ..This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study...
  55. pmc Outcomes associated with phosphorus binders in men with non-dialysis-dependent CKD
    Csaba P Kovesdy
    Division of Nephrology, Salem Veterans Affairs Medical Center, Salem, VA 24153, USA
    Am J Kidney Dis 56:842-51. 2010
    b>Phosphorus binders are used to treat hyperphosphatemia in maintenance dialysis patients, in whom the use of these medications has been associated with lower mortality in some observational studies...
  56. doi Quantitative trait loci for root morphology in response to low phosphorus stress in Brassica napus
    Mei Yang
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, 430070, China
    Theor Appl Genet 121:181-93. 2010
    b>Phosphorus (P) deficiency in soils is a major limiting factor for crop growth worldwide. Changes in root morphology and architecture represent as an important mechanism of adaptation of plants to low P (LP) stress...
  57. doi A bacterium that can grow by using arsenic instead of phosphorus
    Felisa Wolfe-Simon
    NASA Astrobiology Institute, USA
    Science 332:1163-6. 2011
    Life is mostly composed of the elements carbon, hydrogen, nitrogen, oxygen, sulfur, and phosphorus. Although these six elements make up nucleic acids, proteins, and lipids and thus the bulk of living matter, it is theoretically possible ..
  58. doi Essential role of MYB transcription factor: PvPHR1 and microRNA: PvmiR399 in phosphorus-deficiency signalling in common bean roots
    Oswaldo Valdés-López
    Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico, Cuernavaca, Mor Mexico
    Plant Cell Environ 31:1834-43. 2008
    b>Phosphorus (P), an essential element for plants, is one of the most limiting nutrients for plant growth. A few transcription factor (TF) genes involved in P-starvation signalling have been characterized for Arabidopsis thaliana and rice...
  59. doi Calcium, phosphorus, PTH and death rates in a large sample of dialysis patients from Latin America. The CORES Study
    Manuel Naves-Díaz
    Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Universidad de Oviedo, Julian Claveria s n, 33006 Oviedo, Spain
    Nephrol Dial Transplant 26:1938-47. 2011
    ..Mineral metabolism parameters may play a role in the survival of patients with chronic kidney disease (CKD)...
  60. pmc A metagenome of a full-scale microbial community carrying out enhanced biological phosphorus removal
    Mads Albertsen
    Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Aalborg, Denmark
    ISME J 6:1094-106. 2012
    Enhanced biological phosphorus removal (EBPR) is widely used for removal of phosphorus from wastewater. In this study, a metagenome (18...
  61. pmc Physiological and transcriptome analysis of iron and phosphorus interaction in rice seedlings
    Luqing Zheng
    Joint Research Laboratory in Genomics and Nutriomics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China
    Plant Physiol 151:262-74. 2009
    The antagonistic interaction between iron (Fe) and phosphorus (P) has been noted in the area of plant nutrition...
  62. ncbi Phosphorus levels are associated with subclinical atherosclerosis in the general population
    Stephen J Onufrak
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States
    Atherosclerosis 199:424-31. 2008
    Elevated serum phosphorus has been linked to mortality among patients with renal failure and in one study in the general population...
  63. doi Arbuscular mycorrhizal inhibition of growth in barley cannot be attributed to extent of colonization, fungal phosphorus uptake or effects on expression of plant phosphate transporter genes
    E J Grace
    The University of Adelaide, Adelaide, SA 5005, Australia
    New Phytol 181:938-49. 2009
    Here, we used phosphorus-32 (32P) labelling in compartmented pots combined with quantitative real-time polymerase chain reaction (PCR) analysis of phosphate(Pi) transporter gene expression to investigate regulation of Pi uptake pathways ..
  64. ncbi Leaf nitrogen and phosphorus stoichiometry across 753 terrestrial plant species in China
    Wenxuan Han
    Department of Ecology, College of Environmental Sciences and Key Laboratory for Earth Surface Processes of the Ministry of Education, Peking University, Beijing, China
    New Phytol 168:377-85. 2005
    Leaf nitrogen and phosphorus stoichiometry of Chinese terrestrial plants was studied based on a national data set including 753 species across the country...
  65. ncbi Terrestrial phosphorus limitation: mechanisms, implications, and nitrogen-phosphorus interactions
    Peter M Vitousek
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Ecol Appl 20:5-15. 2010
    ..productivity and other biological processes is widespread in terrestrial ecosystems, and nitrogen (N) and phosphorus (P) are the most common limiting elements, both individually and in combination...
  66. ncbi Stoichiometry in an ecological context: testing for links between Daphnia P-content, growth rate and habitat preference
    William R DeMott
    Department of Biology, Indiana Purdue University, Fort Wayne, IN 46805, USA
    Oecologia 142:20-7. 2005
    ....
  67. pmc Quantitative profiling of Arabidopsis polar glycerolipids in response to phosphorus starvation. Roles of phospholipases D zeta1 and D zeta2 in phosphatidylcholine hydrolysis and digalactosyldiacylglycerol accumulation in phosphorus-starved plants
    Maoyin Li
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Physiol 142:750-61. 2006
    b>Phosphorus is an essential macronutrient that often limits plant growth and development. Under phosphorus-limited conditions, plants undergo substantial alterations in membrane lipid composition to cope with phosphorus deficiency...
  68. ncbi Longitudinal and vertical trends of bacterial limitation by phosphorus and carbon in the Mediterranean Sea
    F Van Wambeke
    Laboratoire de Microbiologie Marine, CNRS INSU, UMR 6117, Centre d Oceanologie de Marseille, Universite de la Mediterranee, Campus de Luminy, Case 907, 13 288 Marseille Cedex 9, France
    Microb Ecol 43:119-33. 2002
    ..Bacteria shifted from P to C limitation at a depth where soluble reactive phosphorus was still undetectable, but corresponding to a strong increase in alkaline phosphatase turnover time...
  69. ncbi Expression analysis suggests novel roles for members of the Pht1 family of phosphate transporters in Arabidopsis
    Stephen R Mudge
    CSIRO Division of Plant Industry, 120 Meiers Road, Indooroopilly, Queensland 4068, Australia
    Plant J 31:341-53. 2002
    ..As a step towards identifying the role of this gene family in phosphorus nutrition, we have isolated the promoter regions from each of these genes, and fused them to the reporter genes ..
  70. doi Direct and indirect influences of 8 yr of nitrogen and phosphorus fertilization on Glomeromycota in an alpine meadow ecosystem
    Yongjun Liu
    School of Life Sciences, Lanzhou University, Lanzhou 730000, China
    New Phytol 194:523-35. 2012
    ....
  71. doi Biological stoichiometry of plant production: metabolism, scaling and ecological response to global change
    J J Elser
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    New Phytol 186:593-608. 2010
    ..Although vascular plants exhibit wide variation in foliar carbon:nitrogen:phosphorus ratios, they exhibit a higher degree of 'stoichiometric homeostasis' than previously appreciated...
  72. doi Molecular analysis of the phosphorus starvation response in Trichodesmium spp
    Elizabeth D Orchard
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Environ Microbiol 11:2400-11. 2009
    ..These regions are often characterized by low phosphorus (P) concentrations, and P starvation of Trichodesmium could limit growth, and potentially constrain nitrogen ..
  73. doi Shifts in lake N:P stoichiometry and nutrient limitation driven by atmospheric nitrogen deposition
    James J Elser
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Science 326:835-7. 2009
    ..Here we show that atmospheric N deposition increased the stoichiometric ratio of N and phosphorus (P) in lakes in Norway, Sweden, and Colorado, United States, and, as a result, patterns of ecological nutrient ..
  74. doi Ecoenzymatic stoichiometry of microbial organic nutrient acquisition in soil and sediment
    Robert L Sinsabaugh
    Biology Department, University of New Mexico, Albuquerque, New Mexico 871312, USA
    Nature 462:795-8. 2009
    Biota can be described in terms of elemental composition, expressed as an atomic ratio of carbon:nitrogen:phosphorus (refs 1-3)...
  75. pmc Global patterns of plant leaf N and P in relation to temperature and latitude
    Peter B Reich
    Department of Forest Resources, University of Minnesota, St Paul, 55108 6112, USA
    Proc Natl Acad Sci U S A 101:11001-6. 2004
    A global data set including 5,087 observations of leaf nitrogen (N) and phosphorus (P) for 1,280 plant species at 452 sites and of associated mean climate indices demonstrates broad biogeographic patterns...
  76. pmc Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysis
    Markus Ketteler
    Nephrologische Klinik, Klinikum Coburg gGmbH, Ketschendorfer Strasse 33, 96450 Coburg, Germany
    Clin J Am Soc Nephrol 3:1125-30. 2008
    ..This study investigated the ability of sevelamer carbonate to control serum phosphorous in hyperphosphatemic patients who had chronic kidney disease and were not on dialysis...
  77. ncbi Improvement of Baltic proper water quality using large-scale ecological engineering
    Anders Stigebrandt
    Earth Sciences Centre, Goteborg University, Sweden
    Ambio 36:280-6. 2007
    ..Sustainable improvements in water quality by the reduction of phosphorus (P) supplies will take several decades before giving full effects because of large P storages both in soils in ..
  78. pmc Phosphorus stress in common bean: root transcript and metabolic responses
    Georgina Hernandez
    Centro de Ciencias Genómicas Universidad Nacional Autónoma de México, 66210 Cuernavaca, Mor, Mexico
    Plant Physiol 144:752-67. 2007
    b>Phosphorus (P) is an essential element for plant growth. Crop production of common bean (Phaseolus vulgaris), the most important legume for human consumption, is often limited by low P in the soil...
  79. ncbi Phylogenetic and growth form variation in the scaling of nitrogen and phosphorus in the seed plants
    Andrew J Kerkhoff
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Am Nat 168:E103-22. 2006
    ..Allocation of nitrogen (N) and phosphorus (P) is of particular interest because N and P play pivotal roles in many aspects of plant biology, and their ..
  80. doi Leaf nitrogen:phosphorus stoichiometry across Chinese grassland biomes
    Jin sheng He
    Department of Ecology, Peking University, 5 Yiheyuan Road, 100871 Beijing, China
    Oecologia 155:301-10. 2008
    ..This study suggests that geographic variation and between-species variation, rather than climatic variation, are the major determinants of grassland foliar stoichiometry at the biome level...
  81. doi Climate change effects on runoff, catchment phosphorus loading and lake ecological state, and potential adaptations
    Erik Jeppesen
    Dep of Freshwater Ecology, NERI, Aarhus Univ, Vejlsøvej 25, DK 8600 Silkeborg, Denmark
    J Environ Qual 38:1930-41. 2009
    Climate change may have profound effects on phosphorus (P) transport in streams and on lake eutrophication...
  82. ncbi Reactive oxygen species and root hairs in Arabidopsis root response to nitrogen, phosphorus and potassium deficiency
    Ryoung Shin
    Donald Danforth Plant Science Center, 975 North Warson Rd, St Louis, MO 63132, USA
    Plant Cell Physiol 46:1350-7. 2005
    ..To determine the role of ROS in plant response to nitrogen and phosphorus deficiency, studies were conducted using wild-type Arabidopsis and several root hair mutants...
  83. doi A transgenic approach to enhance phosphorus use efficiency in crops as part of a comprehensive strategy for sustainable agriculture
    Roberto A Gaxiola
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, United States
    Chemosphere 84:840-5. 2011
    Concerns about phosphorus (P) sustainability in agriculture arise not only from the potential of P scarcity but also from the known effects of agricultural P use beyond the field, i.e...
  84. doi Effects of ZnO nanoparticles on wastewater biological nitrogen and phosphorus removal
    Xiong Zheng
    State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China
    Environ Sci Technol 45:2826-32. 2011
    ..However, the potential impacts of ZnO NPs on wastewater nitrogen and phosphorus removal with an activated sludge process are unknown...
  85. doi Biomedical applications of the ESRF synchrotron-based microspectroscopy platform
    S Bohic
    INSERM U 836, Team 6, Rayonnement Synchrotron et Recherche Médicales, Grenoble Institut des Neurosciences, Grenoble 38042, France
    J Struct Biol 177:248-58. 2012
    ..Possibilities offered by these techniques in the biomedical field are described through examples of applications performed at the ESRF synchrotron-based microspectroscopy platform (ID21 and ID22 beamlines)...
  86. doi Eco-physiological adaptations that favour freshwater cyanobacteria in a changing climate
    Cayelan C Carey
    Department of Ecology and Evolutionary Biology, Corson Hall, Cornell University, Ithaca, NY 14853, USA
    Water Res 46:1394-407. 2012
    ..specifically, the ability to grow in warmer temperatures; buoyancy; high affinity for, and ability to store, phosphorus; nitrogen-fixation; akinete production; and efficient light harvesting, vary amongst cyanobacteria genera and ..
  87. ncbi Stoichiometric controls of nitrogen and phosphorus cycling in decomposing beech leaf litter
    Maria Mooshammer
    Department of Chemical Ecology and Ecosystem Research, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
    Ecology 93:770-82. 2012
    ..After three and six months, we measured various aspects of nitrogen and phosphorus cycling...
  88. doi Binary and ternary doping of nitrogen, boron, and phosphorus into carbon for enhancing electrochemical oxygen reduction activity
    Chang Hyuck Choi
    Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 305 701, Republic of Korea
    ACS Nano 6:7084-91. 2012
    ....
  89. doi Eliminating the purple acid phosphatase AtPAP26 in Arabidopsis thaliana delays leaf senescence and impairs phosphorus remobilization
    Whitney D Robinson
    Department of Biology, Queen s University, Kingston, Ontario, Canada
    New Phytol 196:1024-9. 2012
    Limitation of crop productivity by suboptimal phosphorus (P) nutrition is a widespread concern. Enhanced crop P-use efficiency could be achieved by improving P remobilization from senescing leaves to developing tissues and seeds...
  90. doi Does microbial stoichiometry modulate eutrophication of aquatic ecosystems?
    A K Steenbergh
    Department of Microbial Ecology, Netherlands Institute of Ecology NIOO KNAW, P O Box 50, 6700 AB, Wageningen, The Netherlands
    Environ Microbiol 15:1572-9. 2013
    The stoichiometry of prokaryotes (Bacteria and Archaea) can control benthic phosphorus (P) fluxes relative to carbon (C) and nitrogen (N) during organic matter remineralization...
  91. ncbi Evidence for a three-way trade-off between nitrogen and phosphorus competitive abilities and cell size in phytoplankton
    Kyle F Edwards
    Kellogg Biological Station, Michigan State University, Hickory Corners, Michigan 49060, USA
    Ecology 92:2085-95. 2011
    ..Here we demonstrate a three-way trade-off between cell size and competitive abilities for nitrogen and phosphorus in marine and freshwater phytoplankton...
  92. ncbi Rapid nutrient cycling in leaf litter from invasive plants in Hawai'i
    Steven D Allison
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Oecologia 141:612-9. 2004
    ..rates, and nutrient dynamics in 11 understory plants from the Hawaiian islands in control and nitrogen + phosphorus fertilized plots...
  93. pmc Evidence for reactive reduced phosphorus species in the early Archean ocean
    Matthew A Pasek
    Department of Geology, University of South Florida, Tampa, FL 33620, USA
    Proc Natl Acad Sci U S A 110:10089-94. 2013
    ..other organophosphates under plausible early Earth conditions has proved difficult, with the incorporation of phosphorus (P) causing a particular problem because phosphate, where most environmental P resides, is relatively insoluble ..
  94. ncbi Controls over leaf litter decomposition in wet tropical forests
    William R Wieder
    Institute for Arctic and Alpine Research INSTAAR, University of Colorado, Boulder, Colorado 80309, USA
    Ecology 90:3333-41. 2009
    ..which mass loss rates are positively correlated with rainfall up to very high rates of mean annual precipitation and highlight the importance of phosphorus availability in controlling microbial processes in many lowland tropical forests.
  95. doi Transgenic barley (Hordeum vulgare L.) expressing the wheat aluminium resistance gene (TaALMT1) shows enhanced phosphorus nutrition and grain production when grown on an acid soil
    Emmanuel Delhaize
    CSIRO Plant Industry, Canberra, ACT 2601, Australia
    Plant Biotechnol J 7:391-400. 2009
    ..sibling line when grown on an acidic and highly phosphate-fixing ferrosol supplied with a range of phosphorus concentrations...
  96. ncbi Nature of phosphorus limitation in the ultraoligotrophic eastern Mediterranean
    T F Thingstad
    Department of Biology, University of Bergen, Bergen, Norway
    Science 309:1068-71. 2005
    Phosphate addition to surface waters of the ultraoligotrophic, phosphorus-starved eastern Mediterranean in a Lagrangian experiment caused unexpected ecosystem responses...
  97. pmc New insights into globoids of protein storage vacuoles in wheat aleurone using synchrotron soft X-ray microscopy
    Marjana Regvar
    University of Ljubljana, Jamnikarjeva 101, Ljubljana, Slovenia
    J Exp Bot 62:3929-39. 2011
    ....
  98. doi Total recovery of nitrogen and phosphorus from three wetland plants by fast pyrolysis technology
    Wu Jun Liu
    Department of Chemistry, University of Science and Technology of China, Hefei, PR China
    Bioresour Technol 102:3471-9. 2011
    ..bio-oil and char were analyzed, and the results show that a low temperature was appropriate for the nitrogen and phosphorus enrichment in char...
  99. doi The effect of resource quantity and resource stoichiometry on microbial carbon-use-efficiency
    Katharina M Keiblinger
    BFW Federal Research and Training Centre for Forests, Natural Hazards and Landscape, Vienna, Austria
    FEMS Microbiol Ecol 73:430-40. 2010
    ..two bacteria (Pectobacterium carotovorum and Verrucomicrobium spinosum) - under 12 unique C, nitrogen (N) and phosphorus (P) ratios. Whereas the CUE of A...
  100. doi The origins of the Redfield nitrogen-to-phosphorus ratio are in a homoeostatic protein-to-rRNA ratio
    Irakli Loladze
    Department of Mathematics, University of Nebraska Lincoln, Lincoln, NE 68588 0130, USA
    Ecol Lett 14:244-50. 2011
    One of the most intriguing patterns in the biosphere is the similarity of the atomic nitrogen-to-phosphorus ratio (N:P) = 16 found in waters throughout the deep ocean and in the plankton in the upper ocean. Although A.C...
  101. doi Relationships among net primary productivity, nutrients and climate in tropical rain forest: a pan-tropical analysis
    Cory C Cleveland
    Department of Ecosystem and Conservation Sciences, University of Montana, Missoula, MT 59812, USA
    Ecol Lett 14:939-47. 2011
    ..forests (< 1000 m), a regression tree analysis revealed that foliar and soil-based measurements of phosphorus (P) were the only variables that explained a significant proportion of the variation in ANPP, although the ..

Research Grants65

  1. Metabolic MRI of Diabetic Lower Extremity Disease
    Robert L Greenman; Fiscal Year: 2010
    ..MRS) has been validated as a tool that can assess ischemia in muscle tissue by measuring the cellular phosphorus-31 (31P) metabolites, its use has been limited due to its poor spatial and temporal resolution...
  2. Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant Depression
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..31-Phosphorus Magnetic Resonance Spectroscopic Imaging (31P-MRSI), a safe and non-invasive imaging method, allows in vivo ..
  3. METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIA
    DOUGLAS CORBETT HEIMBURGER; Fiscal Year: 2010
    ..our criterion for RS at 1 or more visits;4 of 19 cohort mortalities had RS;and 5 subjects with RS survived after phosphorus supplementation...
  4. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..attributed to 8 trace elements and heavy metals such as copper, sulfur, lead, arsenic, zinc, selenium and 9 phosphorus. Furthermore, animal feed recalls by FDA from 2009-2012 have included 10 contamination events from zinc, ..
  5. Novel Phosphate Binder: Effects on Hyperphosphatemia, Vascular Calcification & Bo
    DEANNA J contact NELSON; Fiscal Year: 2010
    ..While medicines exist that bind phosphorus effectively, all current forms of phosphate binder therapy are associated with very poor patient compliance due ..
  6. Central Biochemistry Laboratory of the CKiD Consortium
    George J Schwartz; Fiscal Year: 2013
    ..Blood analytes include electrolytes, BUN, creatinine, glucose, calcium, phosphorus, albumin, uric acid, lipid screen, hsCRP, intact PTH, and cystatin C...
  7. Regulation Of Inorganic Phosphorus (Pi) Metabolism By Estrogen
    Hassane Amlal; Fiscal Year: 2013
    ..provided by applicant): The long-term objective of this proposal is to study the regulation of inorganic phosphorus (Pi) homeostasis by female sex steroids, mainly Estrogen (E2)...
  8. Vitamin D and Arterial Function in Patients with Chronic Kidney Disease
    Jessica B Kendrick; Fiscal Year: 2013
    ..Subjects will have these measurements performed at baseline and at 6 months and will have calcium and phosphorus drawn monthly to assess safety. This study will answer the important clinical question of whether nutritional (i...
  9. The role of polyphosphate and acidocalcisomes in Trypanosoma brucei
    Roberto Docampo; Fiscal Year: 2013
    ..The acidocalcisome is a dense, acidic organelle with a high concentration of phosphorus present as pyrophosphate and polyphosphate complexed with calcium, and other cations...
  10. A Novel Approach to Phosphorus Lowering in Patients with Chronic Kidney Disease
    Joachim H Ix; Fiscal Year: 2013
    ..Among such factors, higher serum phosphorus (Pi) levels represent a causal candidate, and may be modifiable...
  11. The Roles of FAM20C (DMP4) in Odontogenesis and Osteogenesis
    Chunlin Qin; Fiscal Year: 2013
    ..in mice leads to: 1) significant defects in the dentin, cementum, enamel and bone;2) a decreased serum level of phosphorus in contrast to an elevated serum level of fibroblast growth factor 23 (FGF23);3) loss of normal morphology of ..
  12. Impact of disordered mineral metabolism on stroke and cognitive impairment
    ORLANDO M GUTIERREZ; Fiscal Year: 2013
    ..Disturbances in vitamin D and phosphorus metabolism have emerged as non-traditional risk factors for adverse cardiovascular outcomes...
  13. Imaging Biomarkers for Evaluating Mitochondrial Function in Diabetes
    Geoffrey David Clarke; Fiscal Year: 2013
    ..b>Phosphorus-31 nuclear magnetic resonance spectroscopy can be used to demonstrate impaired metabolism in subjects with ..
  14. A model of kidney stone disease using D. melanogaster
    Marshall Stoller; Fiscal Year: 2013
    ..The fly tubule produces crystalline concretions containing calcium, phosphorus, and other ions combined with an organic matrix...
  15. MAGNETIZATION TRANSFER MRS IN METHAMPHETAMINE USERS RESUBMISSION
    Young Hoon Sung; Fiscal Year: 2013
    ..In the current application, we propose to use phosphorus-31 magnetization transfer image-selected in vivo spectroscopy (31P MT ISIS) to measure forward CK activity (kfor)..
  16. Protein intake, nutrition and cardiovascular disease in stage V CKD
    Srinivasan Beddhu; Fiscal Year: 2011
    ..On the other hand, it also been suggested that high protein intake might t serum phosphorus and arterial calcification with the attendant consequences of arterial stiffness and myocardial stress...
  17. Inhibition of Intestinal Na/Phosphate Cotransporter in Renal Failure and Hyperten
    BRIAN EDWARD PEERCE; Fiscal Year: 2012
    ..Serum phosphorus (Pi) levels are thought to be the crux of the problem In CKD contributing to the rate of disease progression and ..
  18. The Mechanism of Uremia Induced Vascular Calcification
    Sharon M Moe; Fiscal Year: 2013
    ..show that the effect of uremia on vascular smooth muscle cells (VSMC) de-differentiation is additive to that of phosphorus. Once the VSMC become osteoblast like, they secrete matrix vesicles (MV) that interact with the extracellular ..
  19. Molecular regulation of renal 125(OH)2D production by Fibroblast Growth Factor23
    Farzana Perwad; Fiscal Year: 2010
    1,25-dihydroxyvitamin D (1,25(OH)2 D) is a critical determinant of calcium (Ca) and phosphorus (Pi) metabolism and is essential for bone growth and mineralization...
  20. Exploring the interrelationships of mineral metabolism pathways in kidney disease
    Jason Stubbs; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Fibroblast growth factor 23 (FGF23) is a novel hormone that has been found to regulate phosphorus and vitamin D levels in the body, and it is extremely elevated in patients with kidney disease...
  21. SPRINT - Factors Affecting Atherosclerosis Study (FAST)
    Srinivasan Beddhu; Fiscal Year: 2013
    ..2) Whether abdominal obesity and factors reflective of abnormal bone and mineral metabolism (plasma calcium, phosphorus, alkaline phosphatase, 25 and 1,25 vitamin D and fibroblast growth factor 23 levels) play a significant role in ..
  22. Racial Differences in Phosphorus Metabolism in Health and in Kidney Disease
    ORLANDO M GUTIERREZ; Fiscal Year: 2012
    ....
  23. Limited Competition: Frequent Hemodialysis Network (U01)
    Nathan W Levin; Fiscal Year: 2010
    ..hemoglobin control, choice of accesses, longer dialysis time, salt restriction, exercise, control of calcium and phosphorus metabolism and other approaches...
  24. Fibroblast Growth Factor 23 (FGF23) and It's Receptors
    Jyothsna Gattineni; Fiscal Year: 2013
    ..FGFR1, FGFR3 and FGFR4 are present in the proximal tubule where the majority of phosphorus is reabsorbed...
  25. The Role of FGF23 in the Pathogenesis of Chronic Kidney Disease
    ANSEL PHILIP AMARAL; Fiscal Year: 2013
    ..Disordered phosphorus metabolism is one of the most common complications that contribute to decreased lifespan in CKD...
  26. Bone metabolism and bone metastases in prostate cancer
    Kathryn M Wilson; Fiscal Year: 2013
    ..some risk factors for advanced prostate cancer, including obesity and dietary factors like calcium, vitamin D, phosphorus, and vitamin K, may impact prostate cancer progression through their effects on tumor expression of bone-related ..
  27. Mineral metabolism disturbances and arteriovenous fistula maturation
    Bryan R Kestenbaum; Fiscal Year: 2013
    ..Early kidney disease leads to phosphorus retention, which is connected with arterial calcification in cell culture models and in individuals who have ..
  28. Phosphorus and Vitamin D Metabolism and Cardiovascular Outcomes: The MESA Study
    Bryan R Kestenbaum; Fiscal Year: 2013
    ..The proposed studies will determine whether phosphorus excess and vitamin D deficiency are linked with clinically relevant CVD in a racially and ethnically diverse ..
  29. Phosphorus-based Food Additives, Mineral Metabolism and Cardiovascular Health
    ORLANDO M GUTIERREZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mounting evidence suggests that disturbances in phosphorus metabolism contribute to excess cardiovascular disease events and death independently of established risk factors...
  30. Identifying Risk Factors and Improving Risk Assessment for Nephrolithiasis
    Eric N Taylor; Fiscal Year: 2013
    ..Higher urine calcium is a major risk factor for KS. Existing human studies of calcium-phosphorus regulatory hormones on KS formation are widely cited and substantially impact clinical care and KS research...
  31. Patient Oriented Research in Vitamin D Deficiency in CKD
    MARY BETH LEONARD; Fiscal Year: 2013
    ..Innovations include the use of a case-cohort design (the first in CRIC), annual measures of 25(OH)D, FGF-23 and phosphorus levels that will capture cumulative effects over a 4-year interval, and assessment of the effects of vitamin D ..
  32. The Enzymology of Phosphonate Metabolism
    Frank M Raushel; Fiscal Year: 2013
    ..b>Phosphorus is an integral component of nucleic acids, carbohydrates and phospholipids...
  33. MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISM
    Harald W Jueppner; Fiscal Year: 2012
    ..ion homeostasis may help in the treatment of common disorders such as osteoporosis and nephrolithiasis, and are likely to provide new approaches for lowering serum phosphorus levels in chronic kidney disease (CKD) thus improving outcome.
  34. Renal Osteodystrophy and Vascular Calcification
    Keith A Hruska; Fiscal Year: 2013
    ..In the third aim, the mechanism of phosphorus (Pi) stimulation of vascular calcification through the heterotopic vascular osteogenic program activated by BMP-..
  35. Noninvasive assessment of microvascular function in aging
    Jill M Slade; Fiscal Year: 2013
    ..Echo planar fMRI will be used to acquire muscle BOLD images;phosphorus spectroscopy will be used to evaluate PCr kinetics...
  36. XLas Relative to Gsa in Bone and Mineral Ion Metabolism
    Murat Bastepe; Fiscal Year: 2013
    ..XLKO) mice, these led us to hypothesize that XL[unreadable]s is necessary for the regulation of calcium and phosphorus metabolism in vivo...
  37. FGF-23 Regulation in Chronic Kidney Disease
    Katherine Wesseling-Perry; Fiscal Year: 2013
    ..Currently, calcium, phosphorus, PTH, and vitamin D metabolism are used to monitor bone disease and guide its treatment...
  38. FGF-23 and the Risk of Stroke and Cognitive Decline
    Clinton B Wright; Fiscal Year: 2013
    ..Further, it is not understood if FGF23 and disordered phosphorus metabolism increase the risk of vascular events through small or large vessel damage and whether they are ..
  39. Biosynthesis of Hypotensive Phosphonopeptide Natural Products
    Brian O Bachmann; Fiscal Year: 2010
    ..product 'K-26'from an actinomycete is representative of an uninvestigated class of natural carbon-phosphorus bond containing compounds which incorporate a phosphonic acid analog of tyrosine...
  40. CARDIOVASCULAR RISK MECHANISMS IN CKD
    Keith A Hruska; Fiscal Year: 2013
    ..Recent studies have suggested that the serum phosphorus is associated with cardiovascular risk in the general population, and the role of Pi as a cardiovascular risk ..
  41. Organogold phosphorus-containing compounds as antitumor agents
    Maria Contel; Fiscal Year: 2012
    ..Our specific aims are: (1) Synthesis of gold(I) and gold(III) compounds with pincer phosphorus containing ligands, (2) Study of the cytotoxic/apoptotic properties against human cancer cell lines in vitro, ..
  42. Regulation of renal calcium transport
    Chou Long Huang; Fiscal Year: 2013
    ..The study of Klotho will shed lights on our understanding of how Klotho can lower serum phosphorus (an important factor for longevity of life) without causing bone problems...
  43. Proposal to develop an inexpensive commercial process for the immobilization of l
    ROD PHILLIP MUSSELMAN; Fiscal Year: 2011
    ..b>Phosphorus is an accepted technique for the immobilization of soluble lead in soil...
  44. Early Onset Cigarette smoking effects on brain structure, function and chemistry
    Yasmin Mashhoon; Fiscal Year: 2013
    ..Second, the applicant will learn phosphorus magnetic resonance spectroscopy [31P MRS] methods and to conduct neuropsychological assessments of multiple ..
  45. Phase 2 Study of Magnesium Supplements in the Treatment of PXE
    Mark Lebwohl; Fiscal Year: 2013
    ..Baseline evaluations will be comprised of blood chemistry panel, serum magnesium, calcium and phosphorus levels, complete blood count testing, urinalysis, clinical evaluations, punch biopsy of target lesion, ..
  46. Modulation of Bone's Mechanical Behavior by Bone Quality
    Stefan Judex; Fiscal Year: 2010
    ..g., mineral/matrix ratio, calcium/phosphorus ratio, collagen structure, crystallinity) and/or structure will markedly influence the quality of bone, and will ..
  47. New Building Blocks for the Synthesis of Modified RNAs
    Xianbin Yang; Fiscal Year: 2012
    ..PS2-2'-F-RNAs will also be achiral at phosphorus, eliminating the variable biochemical, biophysical, and biological properties of diastereomeric phosphorothioate ..
  48. New Reagents for the Synthesis of Phosphorodithioate-Modified 2'-O-Methyl RNAs
    Xianbin Yang; Fiscal Year: 2011
    ..PS2-2'-OMe-RNAs will also be achiral at phosphorus, eliminating the variable biochemical, biophysical, and biological properties of diastereomeric phosphorothioate ..
  49. CYCLIC NUCLEOTIDES, CYCLOPHOSPHAMIDES, AND ANTIVIRALS
    WESLEY BENTRUDE; Fiscal Year: 1993
    ..NMR studies of the phosphate ring conformation and phosphorus covalency in model enzyme-cyclic nucleotide systems and of cAMP-PK adducts themselves will be pursued...
  50. New Reagents for RNA-based Therapeutic Technologies
    Xianbin Yang; Fiscal Year: 2013
    ..In addition, RNA containing PS modification(s) are chiral at phosphorus, resulting in two distinct isomers at each PS substitution. Therefore, there is a need for further improvements...
  51. Understanding phosphate metabolism in cancer and metastasis
    Dorothea Fiedler; Fiscal Year: 2013
    ..We hypothesize that a similar situation exists for the phosphorus needs of tumor cells: Rapidly dividing cells should rely on a constant supply of phosphate and exhibit altered ..
  52. Noninvasive assessment of skeletal muscle integrity and function with statin use
    Jill Slade; Fiscal Year: 2009
    ..Aim 1 will examine the effect of statins on skeletal muscle cell membrane turnover by non-invasively measuring phosphorus metabolites with NMR, in particular muscle and blood phosphodiesterase (PDE)...
  53. Effects of Vascular Runx 2 deletion on osteogenesis and calcification in vessels
    Koba A Lomashvili; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Uremic vascular calcification (UVC) is not simply a result of elevated phosphorus and calcium levels. Disregulation in inhibitory and promoting factors, greatly contribute to mineralization in vessels...
  54. MR Studies of Myocardial Creatine Kinase Metabolism
    PAUL BOTTOMLEY; Fiscal Year: 2007
    ..Magnetic resonance spectroscopy (MRS) with phosphorus (31P) is uniquely able to noninvasively assess key metabolites, adenosine triphosphate (ATP) and phosphocreatine ..
  55. PHOSPHORUS-CONTAINING TRANSITION STATE ANALOGS
    Paul Bartlett; Fiscal Year: 1990
    ....
  56. CALCIUM INTAKE, METABOLISM & GESTATIONAL BLOOD PRESSURE
    Cynthia Morris; Fiscal Year: 1990
    ..ionized calcium, parathyroid hormone, calcitonin, and 1,25(OH)2 vitamin D3 concentrations and serum magnesium, phosphorus, sodium, and potassium concentrations...
  57. Probing Diversity Space with Novel Pilot Scale Libraries
    Paul R Hanson; Fiscal Year: 2010
    ..In particular, we will focus our initial efforts on libraries comprised of sulfur and phosphorus-containing small molecules and analogues thereof, we term generally as S- and P-heterocycles...
  58. CHIRAL PHOSPHORUS LIGANDS AND ANTISENSE OLIGONUCLEOTIDES
    William Hersh; Fiscal Year: 1999
    ..focused on carbon, but the purpose of this proposal is the synthesis of two types of compound that are chiral at phosphorus. One type will help direct the formation of chiral carbon compounds via catalytic organometallic reactions, ..
  59. PHOSPHORUS MRS OF NORMAL HUMAN MASSETER MUSCLE
    Octavia Plesh; Fiscal Year: 1991
    High-energy phosphorus metabolism in normal human masseter muscle will be investigated non-invasively by in-vivo phosphorus magnetic resonance spectroscopy (31P MRS)...
  60. IN VIVO DETECTION OF FREE RADICALS USING NMR
    Thomas Clanton; Fiscal Year: 2000
    ..Unlike other nitrone spin traps, DEPMPO contains a phosphorus atom, bound closely to its reactive site, which has enabled us to use phosphorus-nuclear magnetic resonance ..
  61. AUTONOMIC NEURAL EFFECTS OF DIETARY CALCIUM
    JACOB PEULER; Fiscal Year: 1992
    ..High calcium intake also normalized plasma Ca (total) and phosphorus concentrations which were clearly below and above reported normal values, respectively, without Ca ..
  62. SODIUM FLUORIDE, METHYLEUGENOL, & ANTHRAQUINONE
    MILTON HEITMANCIK; Fiscal Year: 1999
    ..Special studies to be conducted at interim sacrifices include hematology; serum calcium, phosphorus, fluoride and alkaline phosphatase; and bone fluoride...
  63. THE MODIFICATION OF DIET IN RENAL DISEASE (MDRD) STUDY
    Lawrence Hunsicker; Fiscal Year: 1993
    ..trial, the objective of which is to determine whether diet containing markedly reduced amounts of protein and phosphorus, with or without supplementation with a mixture of essential ketoacids and amino acids, will prove effective in ..
  64. NONINVASIVE HIGH ENERGY PHOSPHATE IMAGING
    PAUL BOTTOMLEY; Fiscal Year: 1999
    ..b>Phosphorus (31P) magnetic resonance spectroscopy (MRS) is unique in its ability to provide non-invasive access to key HEP ..
  65. Boranophosphate DNA: RNA Hybrids as Probes of RNase H
    Barbara Shaw; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The oligonucleoside boranophosphates (BH3--ODN) are a new class of phosphorus modified oligonucleotides that differ chemically from natural DNA in that a borane (BH-) group replaces one of the non-..