titanium

Summary

Summary: A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)

Top Publications

  1. ncbi Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns
    Martin R Larsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense, Denmark
    Mol Cell Proteomics 4:873-86. 2005
  2. pmc Accuracy and quality assessment of 454 GS-FLX Titanium pyrosequencing
    André Gilles
    Aix Marseille Universite, CNRS, IRD, UMR 6116 IMEP, Equipe Evolution Génome Environnement, Centre Saint Charles, Case 36, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    BMC Genomics 12:245. 2011
  3. pmc Stem cell fate dictated solely by altered nanotube dimension
    Seunghan Oh
    Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2130-5. 2009
  4. pmc De novo assembly and transcriptome analysis of five major tissues of Jatropha curcas L. using GS FLX titanium platform of 454 pyrosequencing
    Purushothaman Natarajan
    Genomics Laboratory, Department of Genetic Engineering, SRM University, Chennai, Tamil Nadu 603 203, India
    BMC Genomics 12:191. 2011
  5. pmc Titanium dioxide nanoparticles in food and personal care products
    Alex Weir
    School of Sustainable Engineering and the Built Environment, Arizona State University, Box 5306, Tempe, Arizona 85287 5306, United States
    Environ Sci Technol 46:2242-50. 2012
  6. ncbi Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
    Jiangxue Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
    Toxicol Lett 168:176-85. 2007
  7. ncbi Nanosize and vitality: TiO2 nanotube diameter directs cell fate
    Jung Park
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, Germany
    Nano Lett 7:1686-91. 2007
  8. ncbi The relationship between the nanostructure of titanium surfaces and bacterial attachment
    Sabrina D Puckett
    Division of Engineering and Department of Orthopaedics, Brown University, Providence, RI 02917, USA
    Biomaterials 31:706-13. 2010
  9. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
  10. ncbi Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Nanotoxicology 6:453-71. 2012

Detail Information

Publications362 found, 100 shown here

  1. ncbi Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns
    Martin R Larsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense, Denmark
    Mol Cell Proteomics 4:873-86. 2005
    ..A putative mechanism for this intriguing effect is presented...
  2. pmc Accuracy and quality assessment of 454 GS-FLX Titanium pyrosequencing
    André Gilles
    Aix Marseille Universite, CNRS, IRD, UMR 6116 IMEP, Equipe Evolution Génome Environnement, Centre Saint Charles, Case 36, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    BMC Genomics 12:245. 2011
    ..We analyze here the quality of 454 sequencing data and identify factors playing a role in sequencing error, through the use of an extensive dataset for Roche control DNA fragments...
  3. pmc Stem cell fate dictated solely by altered nanotube dimension
    Seunghan Oh
    Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2130-5. 2009
    ..Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a ..
  4. pmc De novo assembly and transcriptome analysis of five major tissues of Jatropha curcas L. using GS FLX titanium platform of 454 pyrosequencing
    Purushothaman Natarajan
    Genomics Laboratory, Department of Genetic Engineering, SRM University, Chennai, Tamil Nadu 603 203, India
    BMC Genomics 12:191. 2011
    ..In order to expedite the process of gene discovery, we have undertaken 454 pyrosequencing of normalized cDNAs prepared from roots, mature leaves, flowers, developing seeds, and embryos of J. curcas...
  5. pmc Titanium dioxide nanoparticles in food and personal care products
    Alex Weir
    School of Sustainable Engineering and the Built Environment, Arizona State University, Box 5306, Tempe, Arizona 85287 5306, United States
    Environ Sci Technol 46:2242-50. 2012
    b>Titanium dioxide is a common additive in many food, personal care, and other consumer products used by people, which after use can enter the sewage system and, subsequently, enter the environment as treated effluent discharged to surface ..
  6. ncbi Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
    Jiangxue Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
    Toxicol Lett 168:176-85. 2007
    ..Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO(2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract...
  7. ncbi Nanosize and vitality: TiO2 nanotube diameter directs cell fate
    Jung Park
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, Germany
    Nano Lett 7:1686-91. 2007
    We generated, on titanium surfaces, self-assembled layers of vertically oriented TiO2 nanotubes with defined diameters between 15 and 100 nm and show that adhesion, spreading, growth, and differentiation of mesenchymal stem cells are ..
  8. ncbi The relationship between the nanostructure of titanium surfaces and bacterial attachment
    Sabrina D Puckett
    Division of Engineering and Department of Orthopaedics, Brown University, Providence, RI 02917, USA
    Biomaterials 31:706-13. 2010
    ..In this in vitro study, nanometer sized topographical features of titanium (Ti) surfaces, which have been previously shown to enhance select protein adsorption and subsequent osteoblast (..
  9. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
    ..The current use of nano-TiO(2) may present a health hazard due to its capacity to induce IL-1R signaling, a situation reminiscent of inflammation provoked by asbestos exposure...
  10. ncbi Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Nanotoxicology 6:453-71. 2012
    ..We selected seven commercially interesting materials: Three titanium dioxide-based (two coated rutile; one uncoated anatase), one carbon black (Flamrüss 101), one kaolinite clay, ..
  11. ncbi Regulation of the differentiation of mesenchymal stem cells in vitro and osteogenesis in vivo by microenvironmental modification of titanium alloy surfaces
    Yan Hu
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
    Biomaterials 33:3515-28. 2012
    ..The study therefore presents an alternative to fabricate bio-functionalized Ti6Al4V-based implants for potential application in orthopedics field...
  12. pmc Biofunctionalization of a titanium surface with a nano-sawtooth structure regulates the behavior of rat bone marrow mesenchymal stem cells
    Wenjie Zhang
    Department of Prosthodontics, Ninth People s Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China
    Int J Nanomedicine 7:4459-72. 2012
    ..A series of improved implant surfaces functionalized with nanoscale structures have been fabricated using various methods...
  13. ncbi Diameter of titanium nanotubes influences anti-bacterial efficacy
    Batur Ercan
    School of Engineering, Brown University, Providence, RI 02917, USA
    Nanotechnology 22:295102. 2011
    ..Toward this goal, titanium was created to possess nanotubular surface topographies of highly controlled diameters of 20, 40, 60, or 80 nm, ..
  14. ncbi Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles
    Renping Hu
    Medical College of Soochow University, Suzhou, People s Republic of China
    Biomaterials 31:8043-50. 2010
    b>Titanium dioxide nanoparticles (TiO(2) NPs) are now in daily use including popular sunscreens, toothpastes, and cosmetics. However, the effects of TiO(2) NPs on human body, especially on the central nervous system, are still unclear...
  15. ncbi Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles
    Suxing Gui
    Medical College, Soochow University, Suzhou 215123, People s Republic of China
    J Hazard Mater 195:365-70. 2011
    Numerous studies have demonstrated that damage of kidney of mice can be caused by exposure to titanium dioxide nanoparticles (TiO(2) NPs). However, the molecular mechanism of TiO(2) NPs-induced nephric injury remains unclear...
  16. ncbi Stability and aggregation of metal oxide nanoparticles in natural aqueous matrices
    Arturo A Keller
    University of California, Santa Barbara, USA
    Environ Sci Technol 44:1962-7. 2010
    ..8 microm s(-1) V(-1) cm. These results are key for designing and interpreting nanoparticle ecotoxicity studies in various environmental conditions...
  17. ncbi A clinical and histological evaluation of titanium mini-implants as anchors for orthodontic intrusion in the beagle dog
    M Ohmae
    Department of Orthodontics, School of Dentistry, Showa University, Tokyo, Japan
    Am J Orthod Dentofacial Orthop 119:489-97. 2001
    The aim of this study was to determine the anchorage potential of the titanium mini-implant for orthodontic intrusion of the mandibular posterior teeth...
  18. ncbi Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure
    Shing Huang
    Institute of Biomedical Sciences, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 402, Taiwan
    Toxicol Appl Pharmacol 241:182-94. 2009
    b>Titanium dioxide (TiO2) nano-particles (<100 nm in diameter) have been of interest in a wide range of applications, such as in cosmetics and pharmaceuticals because of their low toxicity...
  19. ncbi Surface treatments of titanium dental implants for rapid osseointegration
    L Le Guehennec
    INSERM U791, LIOAD, Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery, 1 Place Alexis Ricordeau, 44042 Nantes Cedex 1, France
    Dent Mater 23:844-54. 2007
    The osseointegration rate of titanium dental implants is related to their composition and surface roughness. Rough-surfaced implants favor both bone anchoring and biomechanical stability...
  20. ncbi Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management
    David B Warheit
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714 0050, USA
    Toxicol Lett 171:99-110. 2007
    ..To summarize the findings, the results of most of the studies demonstrated low hazard potential in mammals or aquatic species following acute exposures to the ultrafine TiO(2) particle-types tested in this program...
  21. ncbi Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells
    Eun Jung Park
    College of Pharmacy, Dongduk Women s University, 23 1, Wolgok dong, Seongbuk gu, Seoul 136 714, Republic of Korea
    Toxicol Lett 180:222-9. 2008
    ..Cytotoxicities of titanium dioxide nanoparticles of different concentrations (5, 10, 20 and 40 microg/ml) were evaluated in this study using ..
  22. pmc Direct and indirect effects of microstructured titanium substrates on the induction of mesenchymal stem cell differentiation towards the osteoblast lineage
    Rene Olivares-Navarrete
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332 0363, USA
    Biomaterials 31:2728-35. 2010
    Microstructured and high surface energy titanium substrates increase osseointegration in vivo...
  23. ncbi Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles
    Edilberto Bermudez
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 77:347-57. 2004
    A multispecies, subchronic, inhalation study comparing pulmonary responses to ultrafine titanium dioxide (uf-TiO(2)) was performed. Female rats, mice, and hamsters were exposed to aerosol concentrations of 0.5, 2...
  24. ncbi Antibacterial nano-structured titania coating incorporated with silver nanoparticles
    Lingzhou Zhao
    School of Stomatology, The Fourth Military Medical University, No 145 West ChangLe Road, Xi an 710032, China
    Biomaterials 32:5706-16. 2011
    b>Titanium (Ti) implants are widely used clinically but post-operation infection remains one of the most common and serious complications...
  25. ncbi Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles
    Yaling Cui
    Medical College, Soochow University, Suzhou, People s Republic of China
    J Biomed Mater Res A 96:221-9. 2011
    ..effort to examine signaling pathway of inflammation of the mouse liver caused by intragastric administration of titanium dioxide nanoparticles (NPs), we assessed Toll-like receptor-2 (TLR2), TLR-4, IκB kinase (IKK-α, IKK-β), IκB ..
  26. ncbi Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles
    Renping Hu
    Medical College, Soochow University, Suzhou, China
    J Hazard Mater 191:32-40. 2011
    Previous studies demonstrate that the exposure to titanium dioxide nanoparticles (TiO(2) NPs) damages the central nervous system of mice; however, very little is known about the effects of TiO(2) NPs on hippocampal apoptosis or its ..
  27. ncbi Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
    Kohei Yamashita
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Nanotechnol 6:321-8. 2011
    ..Here, we show that silica and titanium dioxide nanoparticles with diameters of 70 nm and 35 nm, respectively, can cause pregnancy complications when ..
  28. pmc Adhesion of osteoblasts to a nanorough titanium implant surface
    Ekaterina Gongadze
    Institute of General Electrical Engineering, University of Rostock, Rostock, Germany
    Int J Nanomedicine 6:1801-16. 2011
    This work considers the adhesion of cells to a nanorough titanium implant surface with sharp edges...
  29. ncbi Improved bone-forming functionality on diameter-controlled TiO(2) nanotube surface
    Karla S Brammer
    Materials Science and Engineering, University of California, San Diego, La Jolla, CA 92093 0411, USA
    Acta Biomater 5:3215-23. 2009
    The titanium dioxide (TiO(2)) nanotube surface enables significantly accelerated osteoblast adhesion and exhibits strong bonding with bone...
  30. ncbi Photo-irradiated titanium dioxide catalyzes site specific DNA damage via generation of hydrogen peroxide
    Kazutaka Hirakawa
    Department of Radiation Chemistry, Life Science Research Center, Mie University, Edobashi 2 174, Tsu Mie 514 8507, Japan
    Free Radic Res 38:439-47. 2004
    b>Titanium dioxide (TiO2) is a potential photosensitizer for photodynamic therapy. In this study, the mechanism of DNA damage catalyzed by photo-irradiated TiO2 was examined using [32P]-5'-end-labeled DNA fragments obtained from human genes...
  31. ncbi Disruption of zebrafish (Danio rerio) reproduction upon chronic exposure to TiO₂ nanoparticles
    Jiangxin Wang
    Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ, USA
    Chemosphere 83:461-7. 2011
    ....
  32. ncbi Impacts of metal oxide nanoparticles on marine phytoplankton
    Robert J Miller
    Department of Ecology, Bren School of Environmental Science and Management, University of California, Santa Barbara, California 93106, USA
    Environ Sci Technol 44:7329-34. 2010
    ..NEC could not be estimated for the other taxa but were within the range of 500-1000 μg L(-1). Our results suggest that effects of metal oxide NPs on marine organisms is likely to vary with particle type and organism taxonomy...
  33. ncbi In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection
    Jinyuan Chen
    College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People s Republic of China
    J Appl Toxicol 29:330-7. 2009
    ..Tissues (spleen, heart, lung, kidney and liver) were collected for titanium content analysis and histopathological examination...
  34. ncbi Toxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus
    Margit Heinlaan
    National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia
    Chemosphere 71:1308-16. 2008
    ..This is the first evaluation of ZnO, CuO and TiO2 toxicity to V. fischeri and T. platyurus. For nano ZnO and nano CuO this is also a first study for D. magna...
  35. pmc Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation
    Ki Chun Yoo
    Laboratory of Molecular Biochemistry, Department of Chemistry, Hanyang University, Seoul, Republic of Korea
    Int J Nanomedicine 7:1203-14. 2012
    b>Titanium dioxide (TiO(2)) has been widely used in many areas, including biomedicine, cosmetics, and environmental engineering...
  36. ncbi Distinctive toxicity of TiO2 rutile/anatase mixed phase nanoparticles on Caco-2 cells
    Kirsten Gerloff
    Particle Research, Leibniz Institut für Umweltmedizinische Forschung IUF at the Heinrich Heine University Düsseldorf, Germany
    Chem Res Toxicol 25:646-55. 2012
    b>Titanium dioxide has a long-standing use as a food additive. Micrometric powders are, e.g., applied as whiteners in confectionary or dairy products...
  37. ncbi Modeled environmental concentrations of engineered nanomaterials (TiO(2), ZnO, Ag, CNT, Fullerenes) for different regions
    Fadri Gottschalk
    Empa, Swiss Federal Laboratories for Materials Testing and Research, Technology and Society Laboratory, CH 9014 St Gallen, Switzerland
    Environ Sci Technol 43:9216-22. 2009
    ..For the other environmental compartments for which ecotoxicological data were available, no risks to organisms are presently expected...
  38. ncbi Titanium dioxide nanotubes enhance bone bonding in vivo
    Lars M Bjursten
    Department of Bioengineering, University of California San Diego, La Jolla, California, USA
    J Biomed Mater Res A 92:1218-24. 2010
    ..We investigate the in vivo bone bonding of two titanium implant surfaces: titanium dioxide (TiO(2)) nanotubes and TiO(2) gritblasted surfaces...
  39. pmc Exposure to titanium dioxide nanomaterials provokes inflammation of an in vitro human immune construct
    Brian C Schanen
    VaxDesign Corporation, 12612 Challenger Parkway, Suite 365, Orlando, Florida 32826, USA
    ACS Nano 3:2523-32. 2009
    ..This study explores titanium dioxide, one of the most widely manufactured nanomaterials, synthesized into its three most common ..
  40. ncbi Oxidative damage to nucleic acids photosensitized by titanium dioxide
    W G Wamer
    Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, Washington, DC 20204, USA
    Free Radic Biol Med 23:851-8. 1997
    ..These results suggest that nucleic acids are a potential target for photooxidative damage sensitized by TiO2, and support the view that TiO2 photocatalyzes free radical formation...
  41. ncbi Titanium dioxide (TiO2) nanoparticles induce JB6 cell apoptosis through activation of the caspase-8/Bid and mitochondrial pathways
    Jinshun Zhao
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 72:1141-9. 2009
    b>Titanium dioxide (TiO(2)), a commercially important material, is used in a wide variety of products...
  42. ncbi Surface functionalization of TiO2 nanotubes with bone morphogenetic protein 2 and its synergistic effect on the differentiation of mesenchymal stem cells
    Min Lai
    Key Laboratory of Biorheological Science and Technology, Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China
    Biomacromolecules 12:1097-105. 2011
    ..The approach presented here has potential application for the development of titanium-based implants for enhanced bone osseointegration.
  43. ncbi Gene expression in liver injury caused by long-term exposure to titanium dioxide nanoparticles in mice
    Yaling Cui
    Medical College, Soochow University, Suzhou 215123, People s Republic of China
    Toxicol Sci 128:171-85. 2012
    Although liver toxicity induced by titanium dioxide nanoparticles (TiO(2) NPs) has been demonstrated, very little is known about the molecular mechanisms of multiple genes working together underlying this type of liver injury in mice...
  44. ncbi Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes
    Ketul C Popat
    Department of Physiology, Division of Bioengineering, University of California, 1700 4th Street, Box 2520, San Francisco, CA 94143 2520, USA
    Biomaterials 28:4880-8. 2007
    ..These nanotubes were fabricated on bulk titanium using anodization techniques...
  45. pmc Mediation of osteogenic differentiation of human mesenchymal stem cells on titanium surfaces by a Wnt-integrin feedback loop
    Rene Olivares-Navarrete
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332, USA
    Biomaterials 32:6399-411. 2011
    ..Human mesenchymal stem cells (HMSCs) undergo osteoblastic differentiation on microstructured titanium (Ti) surfaces in the absence of exogenous factors, but the mechanisms are unknown...
  46. ncbi Factors associated with the stability of titanium screws placed in the posterior region for orthodontic anchorage
    Shouichi Miyawaki
    Department of Orthodontics, Okayama University Graduate School of Medicine and Dentistry, Japan
    Am J Orthod Dentofacial Orthop 124:373-8. 2003
    Recently, implant anchors such as titanium screws have been used for absolute anchorage during edgewise treatment. However, there have been few human studies reporting on the stability of implant anchors placed in the posterior region...
  47. pmc Biological surface coating and molting inhibition as mechanisms of TiO2 nanoparticle toxicity in Daphnia magna
    André Dabrunz
    Institute for Environmental Sciences, University of Koblenz Landau, Landau, Germany
    PLoS ONE 6:e20112. 2011
    ..longer exposure times (72 to 96 h), we found that suspensions of nanosized (∼100 nm initial mean diameter) titanium dioxide (nTiO(2)) led to toxicity in Daphnia magna at nominal concentrations of 3.8 (72-h EC(50)) and 0...
  48. pmc Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
    Karin S Hougaard
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Part Fibre Toxicol 7:16. 2010
    ..Consequently, also toxicological properties may change compared to the parent compound. We examined developmental and neurobehavioral effects following maternal exposure to a nanoparticulate UV-filter (UV-titan L181)...
  49. pmc Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: a toxicogenomic study
    Sabina Halappanavar
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    Environ Mol Mutagen 52:425-39. 2011
    b>Titanium dioxide nanoparticles (nanoTiO(2) ) are used in various applications including in paints. NanoTiO(2) inhalation may induce pulmonary toxicity and systemic effects...
  50. ncbi Ecotoxicity of nanosized TiO2. Review of in vivo data
    Anja Menard
    University of Ljubljana, Faculty of Pharmacy, Askerceva cesta 7, SI 1000 Ljubljana, Slovenia
    Environ Pollut 159:677-84. 2011
    ..A number of practical measures are suggested which should support the generation of reliable QSAR models and so overcome this data inadequacy...
  51. ncbi Evaluation of artifacts and distortions of titanium applicators on 3.0-Tesla MRI: feasibility of titanium applicators in MRI-guided brachytherapy for gynecological cancer
    Yusung Kim
    Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA
    Int J Radiat Oncol Biol Phys 80:947-55. 2011
    The aim of this study was to characterize the levels of artifacts and distortions of titanium applicators on 3.0-Tesla magnetic resonance imaging (MRI).
  52. ncbi Anatase TiO2 single crystals with a large percentage of reactive facets
    Hua Gui Yang
    ARC Centre of Excellence for Functional Nanomaterials, School of Engineering and Australian Institute for Bioengineering and Nanotechnology, Queensland 4072, Australia
    Nature 453:638-41. 2008
    ..A typical example is titanium dioxide (TiO2), which has promising energy and environmental applications...
  53. ncbi Synthetic TiO2 nanoparticle emission from exterior facades into the aquatic environment
    R Kaegi
    Eawag, Ueberlandstrasse 133, CH 8600 Dubendorf, Switzerland
    Environ Pollut 156:233-9. 2008
    ..Microscopic investigations are confirmed by bulk chemical analysis. By combining results from microscopic investigations with bulk chemical analysis we calculated the number densities of synthetic TiO(2) particles in the runoff...
  54. ncbi Toxicological effects of titanium dioxide nanoparticles: a review of in vitro mammalian studies
    I Iavicoli
    Institute of Occupational Medicine, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Eur Rev Med Pharmacol Sci 15:481-508. 2011
    ..raise concerns about development, production route, and diffusion in industrial and consumer products of titanium dioxide nanoparticles (TiO2-NPs)...
  55. pmc Bactericidal activity of photocatalytic TiO(2) reaction: toward an understanding of its killing mechanism
    P C Maness
    The National Renewable Energy Laboratory, Golden, Colorado 80401 3393, USA
    Appl Environ Microbiol 65:4094-8. 1999
    When titanium dioxide (TiO(2)) is irradiated with near-UV light, this semiconductor exhibits strong bactericidal activity...
  56. ncbi Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes
    Su Jin Kang
    School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea
    Environ Mol Mutagen 49:399-405. 2008
    b>Titanium dioxide nanoparticles (nano-TiO2) are widely used as a photocatalyst in air and water remediation. These nanoparticles are known to induce toxicity; however, their cytotoxic mechanism is not fully understood...
  57. ncbi Bone-implant interface strength and osseointegration: Biodegradable magnesium alloy versus standard titanium control
    Christoph Castellani
    Department of Paediatric and Adolescent Surgery, Medical University of Graz, Austria
    Acta Biomater 7:432-40. 2011
    ..osseointegration of a novel biodegradable magnesium alloy (Mg-Y-Nd-HRE, based on WE43) is comparable to that of a titanium control (Ti-6Al-7Nb) currently in clinical use...
  58. ncbi Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure
    Jianhong Wu
    Institute of Clinical Pharmacology, Department of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, PR China
    Toxicol Lett 191:1-8. 2009
    The present study investigated the penetration and potential toxicity of titanium dioxide (TiO(2)) nanoparticles following its dermal exposure in vitro and in vivo...
  59. pmc Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm
    Vicki H Grassian
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Environ Health Perspect 115:397-402. 2007
    ..Nanotechnology offers great promise in many industrial applications. However, little is known about the health effects of manufactured nanoparticles, the building blocks of nanomaterials...
  60. pmc Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice
    Benedicte Trouiller
    Department of Pathology and Laboratory Medicine, Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Cancer Res 69:8784-9. 2009
    b>Titanium dioxide (TiO(2)) nanoparticles are manufactured worldwide in large quantities for use in a wide range of applications including pigment and cosmetic manufacturing...
  61. ncbi Lung exposure to nanoparticles modulates an asthmatic response in a mouse model
    S Hussain
    Research Unit for Lung Toxicology, Dept of Occupational, Environmental and Insurance Medicine, KU Leuven, Leuven, Belgium
    Eur Respir J 37:299-309. 2011
    The aim of this study was to investigate the modulation of an asthmatic response by titanium dioxide (TiO₂) or gold (Au) nanoparticles (NPs) in a murine model of diisocyanate-induced asthma. On days 1 and 8, BALB/c mice received 0...
  62. pmc The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area
    Claire Monteiller
    Institute of Occupational Medicine, Research Park North, Edinburgh, UK
    Occup Environ Med 64:609-15. 2007
    ....
  63. ncbi Effects of titanium surface topography on bone integration: a systematic review
    Ann Wennerberg
    Department of Prosthodontics, Faculty of Odontology, Malmo University, Malmo, Sweden
    Clin Oral Implants Res 20:172-84. 2009
    To analyse possible effects of titanium surface topography on bone integration.
  64. ncbi Titanium dioxide nanoparticles produce phototoxicity in the developing zebrafish
    Ofek Bar-Ilan
    Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin Madison, Madison, WI 53705 2222, USA
    Nanotoxicology 6:670-9. 2012
    ..To investigate this, we chose titanium dioxide nanoparticles (TiO(2)NPs) and developing zebrafish embryos as model systems...
  65. pmc Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms
    Agnes M Scherbart
    IUF Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
    Part Fibre Toxicol 8:31. 2011
    ..The uptake of DQ12 was found to be significantly reduced by all three inhibitors. Our findings suggest that the contrasting AM responses to fTiO2 , ufTiO2 and DQ12 relate to differences in the involvement of specific uptake mechanisms...
  66. ncbi TiO2 nanotubes as drug nanoreservoirs for the regulation of mobility and differentiation of mesenchymal stem cells
    Yan Hu
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People s Republic of China
    Acta Biomater 8:439-48. 2012
    ..TNT) arrays as drug nanoreservoirs for loading of bone morphogenetic protein 2 (BMP2) were constructed on titanium substrates and then covered with multilayered coatings of gelatin/chitosan (Gel/Chi) for controlled drug release...
  67. ncbi The effect of agglomeration state of silver and titanium dioxide nanoparticles on cellular response of HepG2, A549 and THP-1 cells
    Anna Lankoff
    Center for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, 16 Dorodna Str, 03 195 Warsaw, Poland
    Toxicol Lett 208:197-213. 2012
    ..motivation of this study was to examine how the agglomeration/aggregation state of silver (20nm and 200nm) and titanium dioxide (21nm) nanoparticles may affect the kinetics of cellular binding/uptake and ability to induce cytotoxic ..
  68. pmc Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen, Denmark
    Part Fibre Toxicol 9:4. 2012
    ..We compared the toxic effects of the titanium dioxide nanoparticle UV-Titan L181 (NanoTiO2), pure or embedded in a paint matrix...
  69. pmc Quaternized chitosan inhibits icaA transcription and biofilm formation by Staphylococcus on a titanium surface
    Zhao Xiang Peng
    Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Antimicrob Agents Chemother 55:860-6. 2011
    ..different degrees of substitution (DS; referred to as HACC 6%, 18%, and 44%) in preventing biofilm formation on a titanium surface...
  70. pmc Differential responses of osteoblast lineage cells to nanotopographically-modified, microroughened titanium-aluminum-vanadium alloy surfaces
    Rolando A Gittens
    School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Biomaterials 33:8986-94. 2012
    ....
  71. ncbi Titanium allergy: could it affect dental implant integration?
    Allauddin Siddiqi
    Oral Implantology Research Group, Sir John Walsh Research Institute, School of Dentistry, University of Otago, Dunedin, New Zealand
    Clin Oral Implants Res 22:673-80. 2011
    Degradation products of metallic biomaterials including titanium may result in metal hypersensitivity reaction...
  72. ncbi Long-term results following titanium cranioplasty of large skull defects
    Mario Cabraja
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Germany
    Neurosurg Focus 26:E10. 2009
    ..In this retrospective study of large skull defects, the authors compared computer-assisted design/computer-assisted modeled (CAD/CAM) titanium implants for cranioplasty with other frequently used materials described in literature.
  73. ncbi The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions
    Lingzhou Zhao
    School of Stomatology, The Fourth Military Medical University, No 145 West ChangLe Road, Xi an 710032, China
    Biomaterials 31:5072-82. 2010
    Hierarchical hybrid micro/nano-textured titanium surface topographies with titania nanotubes were produced by simple acid etching followed by anodization to mimic the hierarchical structure of bone tissues...
  74. pmc Innovative antimicrobial coating of titanium implants with iodine
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Orthop Sci 17:595-604. 2012
    ..In this study, a clinical trial was performed using an iodine-supported titanium that suppresses the microbial activities.
  75. ncbi Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation
    Eun Jung Park
    College of Pharmacy, Dongduk Women s University, Seoul, Republic of Korea
    Toxicology 260:37-46. 2009
    b>Titanium dioxide nanoparticles (TNP) are nanomaterials which have various applications including photocatalysts, cosmetics, and pharmaceuticals because of their high stability, anticorrosiveness, and photocatalytic properties...
  76. ncbi Effects of serum adsorption on cellular uptake profile and consequent impact of titanium dioxide nanoparticles on human lung cell lines
    Roslyn Tedja
    ARC Centre of Excellence for Functional Nanomaterials, School of Chemical Engineering, The University of New South Wales, Sydney NSW 2052, Australia
    ACS Nano 6:4083-93. 2012
    Exposure to fetal bovine serum (FBS) is shown herein to reduce the aggregate size of titanium dioxide (TiO(2)) nanoparticles, affecting uptake and consequent effect on A549 and H1299 human lung cell lines...
  77. ncbi Vancomycin covalently bonded to titanium alloy prevents bacterial colonization
    Valentin Antoci
    Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, Pennsylvania 19107, USA
    J Orthop Res 25:858-66. 2007
    ..We hypothesized that if an antibiotic can be tethered to a titanium alloy (Ti) surface, it will inhibit bacterial colonization, prevent biofilm formation, and avert late-stage ..
  78. ncbi ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells
    Ritesh K Shukla
    Indian Institute of Toxicology Research, Council of Scientific and Industrial Research CSIR, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, India
    Toxicol In Vitro 25:231-41. 2011
    b>Titanium dioxide nanoparticles (TiO(2) NPs) are among the top five NPs used in consumer products, paints and pharmaceutical preparations...
  79. ncbi Oxidative damage of lung and its protective mechanism in mice caused by long-term exposure to titanium dioxide nanoparticles
    Qingqing Sun
    Medical College of Soochow University, Suzhou 215123, People s Republic of China
    J Biomed Mater Res A 100:2554-62. 2012
    Exposure to titanium dioxide nanoparticles (TiO(2) NPs) elicits an adverse response such as oxidative damage. The molecular targets of TiO(2) NPs remain largely unidentified...
  80. ncbi Oxidative stress and proinflammatory effects of carbon black and titanium dioxide nanoparticles: role of particle surface area and internalized amount
    Salik Hussain
    University Paris Diderot Paris 7, Unit of Functional and Adaptive Biology BFA CNRS EAC 7059, Paris, France
    Toxicology 260:142-9. 2009
    ..surface area and oxidative stress in the cellular effects of two chemically distinct NPs, carbon black (CB) and titanium dioxide (TiO(2)), on the bronchial epithelial cell line (16HBE14o-)...
  81. ncbi High surface energy enhances cell response to titanium substrate microstructure
    G Zhao
    Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Biomed Mater Res A 74:49-58. 2005
    b>Titanium (Ti) is used for implantable devices because of its biocompatible oxide surface layer...
  82. ncbi Toxicity of nanoparticles of CuO, ZnO and TiO2 to microalgae Pseudokirchneriella subcapitata
    Villem Aruoja
    Laboratory of Molecular Genetics, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia
    Sci Total Environ 407:1461-8. 2009
    ..To our knowledge, this is one of the first systematic studies on effects of metal oxide nanoparticles on algal growth and the first describing toxic effects of nano CuO towards algae...
  83. pmc Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells
    Igor Pujalté
    Laboratoire Biologie Cellulaire, FRE CNRS 3396, Université Bordeaux Segalen, 146 rue Leo Saignat, Bordeaux Cedex, France
    Part Fibre Toxicol 8:10. 2011
    ..Comparative studies were conducted, to identify whether particle properties impact cytotoxicity by altering the intracellular oxidative status...
  84. ncbi Age-dependent degradation of the protein adsorption capacity of titanium
    N Hori
    Laboratory for Bone and Implant Sciences, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    J Dent Res 88:663-7. 2009
    ..We tested a hypothesis that the protein adsorption capability of titanium, which is critical to the process of osseointegration, changes over time before its use...
  85. ncbi Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells
    Shichang Liu
    The Key Laboratory of Bioactive Materials, Ministry of Education, College of Medicine, Nankai University, Weijin Rd, Tianjin 300071, China
    Toxicology 267:172-7. 2010
    The nanosized titanium dioxide (nano-TiO2) is produced abundantly and used widely in the chemical, electrical/electronic and energy industries because of its special photovoltaic and photocatalytic activities...
  86. ncbi Time-dependent degradation of titanium osteoconductivity: an implication of biological aging of implant materials
    Wael Att
    Laboratory of Bone and Implant Sciences, The Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    Biomaterials 30:5352-63. 2009
    The shelf life of implantable materials has rarely been addressed. We determined whether osteoconductivity of titanium is stable over time...
  87. ncbi Influence of ionic strength, pH, and cation valence on aggregation kinetics of titanium dioxide nanoparticles
    Rebecca A French
    Center for NanoBioEarth, Department of Geosciences, Virginia Tech, 4044 Derring Hall, Blacksburg, Virginia 24061, USA
    Environ Sci Technol 43:1354-9. 2009
    The extensive use of titanium dioxide nanoparticles (nano-TiO2) in many consumer products has raised concerns about possible risks to the environment The magnitude of the threat may depend on whether nano-TiO2 remains dispersed in the ..
  88. ncbi Nanostructured polyaniline/titanium dioxide composite anode for microbial fuel cells
    Yan Qiao
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457
    ACS Nano 2:113-9. 2008
    ..Thus, it has great potential to be used as the anode for a high-power MFC and may also provide a new universal approach for improving different types of MFCs...
  89. ncbi Genotoxic effects of nanosized and fine TiO2
    G C M Falck
    New Technologies and Risks, Work Environment Development Centre, Finnish Institute of Occupational Health, Helsinki, Finland
    Hum Exp Toxicol 28:339-52. 2009
    ..BEAS 2B cells were exposed to eight doses (1-100 microg/cm(2)) of titanium(IV) oxide nanosized rutile (>95%, <5% amorphous SiO(2) coating; 10 x 40 nm), nanosized anatase (99...
  90. pmc Dispersion and stability optimization of TiO2 nanoparticles in cell culture media
    Zhaoxia Ji
    California NanoSystems Institute, Department of Civil and Environmental Engineering, University of California at Los Angeles, Los Angeles, California 90095, USA
    Environ Sci Technol 44:7309-14. 2010
    ....
  91. ncbi Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles
    Yaling Cui
    Medical College of Soochow University, Renai Road No 199, Suzhou 215123, People s Republic of China
    J Hazard Mater 183:874-80. 2010
    ..Therefore, the application of TiO(2) NPs and exposure effects especially on human liver for long-term and low-dose treatment should be cautious...
  92. pmc Bone growth enhancement in vivo on press-fit titanium alloy implants with acid etched microtexture
    Henrik Daugaard
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Aarhus University Hospital, Norrebrogade 44, Building 1A, DK 8000 Aarhus C, Denmark
    J Biomed Mater Res A 87:434-40. 2008
    ..We used an experimental joint replacement model with cylindrical titanium implants (Ti-6Al-4V) inserted paired and press-fit in cancellous tibia metaphyseal bone of eight canines for 4 ..
  93. ncbi Bacterial adhesion on commercially pure titanium and zirconium oxide disks: an in vivo human study
    Antonio Scarano
    Dental School, University of Chieti, Chieti, Italy
    J Periodontol 75:292-6. 2004
    ..Different adhesion affinities of bacteria have been reported for different materials. The aim of this study was to characterize the percentage of surface covered by bacteria on commercially pure titanium and zirconium oxide disks.
  94. ncbi Coating of titanium implants with collagen, RGD peptide and chondroitin sulfate
    Stefan Rammelt
    Department of Trauma and Reconstructive Surgery, Dresden University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Biomaterials 27:5561-71. 2006
    Coating of orthopaedic implants with extracellular bone matrix components was performed to enhance bone healing. Titanium pins of 0...
  95. ncbi Formation of TiO(2) nano-network on titanium surface increases the human cell growth
    Chih Yao Chiang
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Dent Mater 25:1022-9. 2009
    This study was to improve human cell growth on titanium (Ti) used for dental implants through formation of a nano-network surface oxide layer created by an electrochemical anodization treatment.
  96. ncbi Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO2
    Gabriel Colon
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907 2022, USA
    J Biomed Mater Res A 78:595-604. 2006
    ..ZnO is a well-known antimicrobial agent and TiO(2) readily forms on titanium once implanted. Results of this study provided the first evidence of decreased S...
  97. ncbi Focal adhesion contact formation by fibroblasts cultured on surface-modified dental implants: an in vitro study
    Birte Grössner-Schreiber
    Clinic of Restorative Dentistry and Periodontology, University of Kiel, Kiel, Germany
    Clin Oral Implants Res 17:736-45. 2006
    ..The aim of the present study was to examine the influence of different treatments of titanium (Ti) implant surfaces on focal adhesion contact (FAC) formation in fibroblast cultures...
  98. ncbi The effect of heat- or ultra violet ozone-treatment of titanium on complement deposition from human blood plasma
    Paula Linderbäck
    Division of Applied Physics, Department of Physics and Measurement Technology, Linkoping University, SE 581 83 Linkoping, Sweden
    Biomaterials 31:4795-801. 2010
    b>Titanium (Ti) is a well known metallic biomaterial extensively used in dental, orthopaedic-, and occasionally also in blood contacting applications...
  99. ncbi Optical characteristics of titanium oxide interference film and the film laminated with oxides and their applications for cosmetics
    Takahiro Kaida
    Nihon Koken Kogyo Company, Ltd, Tachikawa shi, Japan
    J Cosmet Sci 55:219-20. 2004
  100. ncbi Mechanical response of nickel-titanium instruments with different cross-sectional designs during shaping of simulated curved canals
    H C Kim
    Department of Conservative Dentistry, School of Dentistry, Pusan National University, Busan, Korea
    Int Endod J 42:593-602. 2009
    To evaluate how different cross-sectional designs affect stress distribution in nickel-titanium (NiTi) instruments during bending, torsion and simulated shaping of a curved canal.
  101. ncbi Control of focal adhesion dynamics by material surface characteristics
    Annette Diener
    Department of Internal Medicine, University of Rostock, Ernst Heydemann Str 6, Rostock 18055, Germany
    Biomaterials 26:383-92. 2005
    ..number, size, and dynamic behavior of focal adhesions in living MG-63 osteoblastic cells, which were cultured on titanium surfaces with different roughnesses and on stainless steel (SS)...

Research Grants66

  1. Novel Titanium Material for Orthopaedic Lumbar Implants
    STANLEY ABKOWITZ; Fiscal Year: 2004
    Dynamet Technology will extend the NSF Phase I development of an innovative titanium-tungsten material to solve a critical need in orthopaedic surgery - a replacement lumbar disc with imaging capability...
  2. Processing of Materials for Improved Biocompatibility
    Michael Matthews; Fiscal Year: 2004
    ..on complex materials, namely flexible polymers (polyurethane and silicone rubber), as well as porous monoliths of titanium. Also in Year 2, the BRP will examine the material surface to search for adverse effects of CO2 processing, such ..
  3. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..Specifically, we measure toxicity of copper oxide and titanium dioxide which are widely used and have important ramifications for human health.
  4. Resolving the role of nicotine-mediated phosphorylation on pancreatic fibrosis
    Joao A Paulo; Fiscal Year: 2013
    ..e., kinase activity assays, titanium dioxide phosphopeptide enrichment and isobaric tandem mass tag (TMT)-based quantitation), I will determine time-..
  5. Pathological Evaluation of a Cystic Fibrosis Ferret Model
    John F Engelhardt; Fiscal Year: 2010
    ..454 GS FLX Titanium deep sequencing technology will be used for transcriptome analyses, giving rise to 3...
  6. Autologous EPC lining to improve biocompatibility of circulatory assist devices
    Jeffrey H Lawson; Fiscal Year: 2010
    ..increase the quality of life for these patients;however, the contact of blood with their inner surface (usually titanium) often causes a coagulopathy resulting in bleeding and thrombosis...
  7. Manipulation of beta-catenin signaling in adult oral cells for tooth regeneration
    Sarah E Millar; Fiscal Year: 2010
    ..Current state-of-the-art therapy relies on artificial titanium/ceramic dental implants that suffer from drawbacks including requiring significant surgical intervention, lack of ..
  8. Microvascular Health and Nanoparticle Exposure
    Timothy R Nurkiewicz; Fiscal Year: 2010
    ..Rats will be exposed to carbon nanotube or nano-titanium dioxide aerosols...
  9. Thromboresistant Polymers via Catalytic Generation of NO
    Mark E Meyerhoff; Fiscal Year: 2012
    ..deposition method to immobilize the RSe sites on any biomedical polymer or device surface (including titanium and stainless steel);3) studying the ability of the polymer coatings devised in (1) and (2) for producing NO ..
  10. Individual Predoctoral Dental Scientist Fellowship
    MELISSA ANNE TALBERT; Fiscal Year: 2011
    ..b>Titanium and titanium alloy, metals used for dental applications, release ions which localize to tissues surrounding ..
  11. Sex Differences in Acute Estradiol Regulation of the Synaptic Proteome
    Catherine S Woolley; Fiscal Year: 2013
    ..females. In Aim 2, we will use strong cation exchange chromatography and titanium dioxide enrichment of phosphopeptides followed by mass spectrometry to identify synaptic proteins that are ..
  12. Combinatorial Metal Oxide Substrates to Enhance Osteogenic Stem Cell Functions
    Jaime E Ramírez-Vick; Fiscal Year: 2012
    ..Specific Aim 1: Develop metal oxide substrates based on titanium that contain gradients of three other metals used as implant materials...
  13. Titanium-gold-based chemotherapeutics for prostate and kidney cancer
    Maria Contel; Fiscal Year: 2013
    ..Platinum-derived drugs, commonly used, have failed in renal and prostate cancers. Titanium-based drugs have high preclinical activity and hold potential for anticancer therapy, especially for metastatic ..
  14. Fabrication and validation of implantable MRI markers for prostate cancer treatme
    Andrew Bright; Fiscal Year: 2010
    ..Prostate brachytherapy (PB) is performed using tiny radioactive (0.1-10 mCi) titanium seeds implanted directly into the prostate gland...
  15. Fabrication of Denture Frameworks Using Titanium Alloys
    Marie Koike; Fiscal Year: 2010
    ..One solution to this problem is to discontinue using these allergy- causing alloys and to replace them with titanium. Treatment with titanium prostheses has resulted in some clinical successes...
  16. MULTIPHOTON CONFOCAL MICROSCOPE
    Liza A Pon; Fiscal Year: 2010
    ..The requested system consists of the Zeiss LSM 710 NLO confocal system and Coherent Chameleon Ultra II titanium-sapphire laser mounted on the Zeiss Axio Observer Z1 inverted microscope...
  17. Innovative Device to Improve Safety of Preparing and Administering Chemotherapy
    Prasad Sunkara; Fiscal Year: 2013
    ..and production quality via published bench-top testing standards, including fluorescein sodium (UV solution) and titanium tetrachloride (visible vapor) tests...
  18. MRI Image Guided Radiation Therapy (IGRT) system with low cost, highly stable mag
    MICHAEL J TOMSIC; Fiscal Year: 2013
    ..Liquid helium is presently essential for operation of present day low temperature niobium-titanium (NbTi) based superconductor magnets...
  19. A novel approach for assessing dynamic events in the human complement system
    Daniel Ricklin; Fiscal Year: 2013
    ..and amplification, and the inhibition thereof will be studied using a clinically relevant model biomaterial (titanium)...
  20. Development of transcriptome-based biomarkers from melanoma in hybrid fish
    Ziping Zhang; Fiscal Year: 2010
    ..We have employed traditional cloning as well as next generation 454 titanium (454-Ti) analyses to examine the Xiphophorus transcriptome...
  21. HLA-DQ Sequencing Studies in Narcolepsy/Hypocretin Deficiency
    Emmanuel J Mignot; Fiscal Year: 2012
    ..It will also make use of the newly developed FLX 454 titanium sequencing technique to generate and analyze high throughput, low cost full HLA DQA1 and DQB1 sequence, and to ..
  22. Vascular Consequences of Multi-Walled Carbon Nanotube Exposure
    PHOEBE STAPLETON; Fiscal Year: 2013
    ..Our laboratory has previously shown that systemic microvascular dysfunction follows after pulmonary titanium-dioxide nanoparticle exposure...
  23. Cationic Steroidal Antimicrobial-13 for Use as an Orthopedic Device Coating
    Kristofer D Sinclair; Fiscal Year: 2012
    ..in vitro testing has demonstrated greater than a 99% reduction of MRSA within 24 hours with exposure to titanium (Ti) plug implants coated with the 18% w/w Si polymer released CSA-13 antimicrobial. OBJECTIVES: 1) Provide Dr...
  24. Neurotoxicity of nanomaterials: evaluation of subcellular redox state
    Gary W Miller; Fiscal Year: 2010
    ..the ability of the manufactured nanomaterials fullerene (C60), fullerol (C60(OH)22-24), manganese oxide (MnO2), titanium dioxide (TiO2), magnetic iron oxide (FeO4), and nanoscale zero valent iron (n-ZVI) to preferentially oxidize ..
  25. Biological Strategies to Mitigate the Adverse Effects of Polymeric Wear Particles
    Stuart B Goodman; Fiscal Year: 2013
    ..and validate a local delivery system in which mutant anti-MCP-1 protein (called 7ND protein) is eluted from a titanium rod in vitro...
  26. Novel coatings on titanium implants for the delivery of stem cells
    MARTYN DARBY; Fiscal Year: 2012
    ..Therefore, the surgeon often relies on alloplastic materials such as titanium mesh, which can be easily shaped, has a modulus of elasticity similar to bone, and is biocompatible...
  27. Cytoxic and Genotoxic Effects of Manufactured Nanoparticles on Stem Cells
    Yiling Hong; Fiscal Year: 2011
    ..carbon NPs (car wax, fuel lines, cosmetics), silver NPs (antimicrobial wound dressings, odor-reducing socks), titanium dioxide NPs (sunscreens, paints), and zinc oxide NPs (sunscreens)...
  28. Inhaled environmental particles, pregnancy and neonatal allergy
    Alexey V Fedulov; Fiscal Year: 2012
    ..Remaricably, this effect is also caused by control, 'inert'titanium dioxide particles...
  29. A Novel Thin Film Nitinol Covered Stent to Treat Peripheral Arterial Disease
    David A Rigberg; Fiscal Year: 2010
    ..Bulk Nitinol is found in many medical devices including most notably stents. Despite being inert due to its titanium oxide layer, thrombosis occurs due to bulk Nitinol's surface roughness and the overall quality of the ..
  30. Illumina Genome Analyzer IIx
    Norma J Nowak; Fiscal Year: 2010
    ..The IDG core currently offers 454-FLX Titanium sequencing as a service to UB-CoEBLS-RPCI...
  31. Adjustable balloon implant for medialization thyroplasty
    Matthew R Hoffman; Fiscal Year: 2012
    ..Several alternatives to Silastic have been proposed, including hydroxyapatite, the titanium vocal fold medializing implant, and Gore-Tex...
  32. Phosphopeptide mapping of plexiform lesions in pulmonary arterial hypertension
    Lawrence S Zisman; Fiscal Year: 2012
    ..b>Titanium dioxide chromatography will be used to enrich for phosphopeptides which will then be identified by mass ..
  33. Multi-electrode Arrays with Non-hermetic Encapsulation for Neural Prostheses
    Stuart F Cogan; Fiscal Year: 2010
    ..employ foil and wire electrodes connected to implantable pulse generators (IPGs) housed in hermetically sealed titanium cans...
  34. BIOMECHANISMS OF TOOTH ERUPTION,RESORPTION & REPLACEMENT
    ZEEV DAVIDOVITCH; Fiscal Year: 1993
    ..They are made of inert (e.g. titanium) or bioactive (e.g...
  35. Orthopedic implant materials with bacteria-resistant and osteogenic functions
    Yuyu Sun; Fiscal Year: 2013
    ..We have demonstrated that treating titanium with sulfuric acid (H2SO4) creates a roughened/porous surface that significantly improve osteogenic activity...
  36. Silica-protein Nanocomposites for Dental Repair
    David L Kaplan; Fiscal Year: 2013
    ..Specifically, bone regeneration and titanium-bone interfaces are two key areas where improvements in interfacial bonding and bone remodeling are in need of ..
  37. NIH SBIR Phase I: UNCD as Bio-Inert Interface for Anti-Thrombogenicity Applicati
    Hongjun Zeng; Fiscal Year: 2011
    ..The substrate materials utilized in the Jarvik 2000 VAD, silicon carbide and titanium, provide an excellent substrate match for UNCD coating...
  38. Point of Care Attachment of Antibiotics onto Metal Implants
    Paul Hamilton; Fiscal Year: 2009
    ..technology, Affinergy has identified a series of peptides that bind with high affinity to metals, including titanium and stainless steel, as well as peptides which bind the antibiotic vancomycin with high affinity...
  39. Infection-Prevention Barriers for Osseointegrated Percutaneous Implants
    David W Grainger; Fiscal Year: 2012
    ..on osseointegrated implants with percutaneous pylons into the tibia of a porcine model: (1) a rigid microporous titanium subcutaneous flange (baseline control), and (2) a novel flexible microporous polyurethane subcutaneous flange...
  40. AFB Smears for Drug Resistance Detection and Surveillance in MTb.
    David Alland; Fiscal Year: 2010
    ..for mutations associated with resistance to the first and second line drugs using sample pools and the Roche 454 Titanium sequencing platform. 3...
  41. Cryo ptychography combined with x-ray fluorescence analysis of metals in cells
    CHRIS JOHNSON JACOBSEN; Fiscal Year: 2013
    ..project, we will do this in the context of ongoing research in the use of DNA-conjugated nanoparticles containing titanium and/or gadolinium that are meant to target mitochondria for the treatment and imaging of prostrate, breast, and ..
  42. ELECTROSTATIC SURFACE OPTIMIZATION FOR OSSEOINTEGRATION
    Michele Marcolongo; Fiscal Year: 2000
    ..In contrast, the more commonly used bone implant materials, titanium alloy (Ti6A14V) and cobalt chromium alloy, will not support osteoblast adhesion and direct bone bonding in vivo, ..
  43. High-Density Hermetic Packaging for Next-Generation Neural Prostheses
    Douglas B Shire; Fiscal Year: 2013
    ..of high-density ceramic feedthroughs and incorporate these into state-of-the- art 200-channel hermetic titanium packages for our retinal microstimulators that will lead to clinically relevant visual prosthetics...
  44. Pulse-shaping for Multiphoton FRET Microscopy in Vivo
    Jennifer P Ogilvie; Fiscal Year: 2012
    ..Broadband titanium-sapphire laser sources offer a stunning range of excitation wavelengths in a single laser source, allowing ..
  45. IN VITRO INVESTIGATION OF SLIDING MECHANICS
    Robert Kusy; Fiscal Year: 2002
    ..Novel materials (titanium brackets and composite archwires) and conventional orthodontic materials (stainless steel, nickel-titanium, beta-..
  46. Peptide Enabled Self Assembled Reconfigurable Implant Coatings
    Candan Tamerler; Fiscal Year: 2013
    ..We recently engineered peptide sequences that are specific to titanium based implant material, successfully coupled them with antimicrobial peptides, and tested their bactericidal ..
  47. Electrodeposited Noble Metal Oxide Neural Electrodes
    Stuart Cogan; Fiscal Year: 2002
    ..processes suitable for coating a broad range of metal substrates such as platinum, gold, PtIr-alloys, titanium, tungsten, and stainless steel, relevant to most neural recording and stimulating electrodes...
  48. The Anelastic Strain Response of Spine Rods in a Biologic Environment
    Reed A Ayers; Fiscal Year: 2010
    ..expertise at the Colorado School of Mines this work will seek to determine the nature of analeastic responses of titanium and its alloys in a simulated body environment via collaboration with the Department of Orthopedics and the ..
  49. Ultraprecision Diamond Machining of Conventional Non-Diamond Machinable Materials
    Gang Zhang; Fiscal Year: 2007
    ..It cannot machine many important materials such as ferrous alloys, stainless steel, titanium and nickel due to catastrophic diamond tool wear...
  50. Phase III Multicenter Study of Magnetic Mini-Mover for Pectus Excavatum G090006 1
    Michael R Harrison; Fiscal Year: 2013
    ..In addition, this initial phase I-II trial has led to minor improvements in the titanium-encased magnetic implant (Magnimplant) and major improvements in the external magnet brace (Magnatract)...
  51. ENHANCEMENT OF LUMBAR FUSION W/ RHBMP 2/ COLLAGEN OR LMP
    Scott D Boden; Fiscal Year: 2011
    ..The growth factor was delivered inside a hollow titanium treated fusion cage through a minimally invasive approach...
  52. Engineered scaffolds for complex craniomaxillofacial reconstructions
    Francesco Migneco; Fiscal Year: 2012
    ..prosthetic devices implanted to fill mandibular bone defects and attached to the adjacent host tissues with titanium plates or screws are prone to failure due to metal fatigue and fracture or bone resorption at the host tissue-..
  53. Manufacturing technology for skin integrated composite prosthetic pylon
    Mark Pitkin; Fiscal Year: 2010
    ..During the proposed Phase II study the investigators will develop an optimal porous titanium matrix and design of the Skin and Bone Integrated Pylon to maximize the ingrowth of bone and skin cells of the ..
  54. Characterizing TiO2 as an Anti-Inflammatory Biomaterial
    John Frangos; Fiscal Year: 2005
    b>Titanium has been successfully used for decades in dental and orthopedic implants, but the exact mechanism of successful osseointegration has not been determined...
  55. Development of Extraocular Muscle Prosthesis for Paralytic Strabismus
    Yasushi Kato; Fiscal Year: 2009
    ..as a protective, elastic envelope that insulates the spring coil from the surrounding orbital tissues;and 3) a titanium, T-shaped bone plate that provides a firm metallic fixation point to the orbit and directs the prosthesis ..
  56. Dental Cast Titanium-Ceramic Bonding
    Zhuo Cai; Fiscal Year: 2003
    ..Since titanium offers both low unit cost and biocompatibility, its use in prosthodontics has been increasing...
  57. RADIO-ULNAR LOAD SHARING IN THE CADAVER FOREARM
    Keith Markolf; Fiscal Year: 2003
    ..Three Specific Aims will be investigated. Specific Aim 1: We will study the effects of implanting a titanium radial head prosthesis upon distal ulnar force and proximal radial displacement during forearm loading tests...
  58. FLEXIBLE MAGNETOHYDRAULIC ACOUSTIC CATHETER
    DAVID WUCHINICH; Fiscal Year: 1991
    ..polyurethane tubing one meter in length that is connected to the transduction cavity and (3) an annular titanium tip which closes and terminates the catheter...
  59. The Role of P4H in Tissue-Titanium Integration
    Takahiro Ogawa; Fiscal Year: 2006
    ..Our long-term goal is to identify the biomechanical and molecular properties in bone-titanium integration and to develop improved implant technology for clinical applications...
  60. A Nanoparticle Respiratory Dose Sampler for Metal-Based Nanoparticles
    THOMAS MICHAEL PETERS; Fiscal Year: 2013
    ..into current personal exposure sampling strategies that can streamline the multi-step process for assessing titanium dioxide nanoparticle exposures...
  61. Osseoinductive Surface Treatment for Dental Implants
    ZORAN MINEVSKI; Fiscal Year: 2005
    ..Lynntech, Inc., through related research involving titanium hip implants, has developed an electrolytic phosphate surface treatment that offers improved surface hardness and ..
  62. Magnetic Nanoparticles for Advanced Hearing Devices
    Charles Seeney; Fiscal Year: 2002
    ..rf-Inductive Plasma will be used to create layered films in which nanoparticles are sandwiched within layers of titanium. 2) Nano-Layer Deposition (LBL): Polyelectrolytes in appropriate media will be used as effective templates for ..
  63. Development of new elastic titanium immediate load implants
    Rong Wang; Fiscal Year: 2007
    ..Recent research has identified a new class of titanium materials with far better mechanical strength and elasticity than the current commercial titanium systems...
  64. METAL CATALYSED ASYMMETRIC DIELS-ALDER REACTIONS
    Brice Bosnich; Fiscal Year: 1991
    ..This proposal is directed at developing chiral catalysts of the elements boron, aluminum, titanium, and tin for the catalytic asymmetric Diels-Alder reaction...
  65. TITANIUM BASED VARIABLE MODULUS ORTHODONTIC WIRE
    LAURENCE SCHETKY; Fiscal Year: 1991
    ..New titanium based shape memory effect alloys show promise of being close to this ideal...
  66. Improved Orthopedic Implant Surface Coatings
    Paul Hamilton; Fiscal Year: 2007
    ..In phase I, we used phage display to identify peptides that bound to titanium with high affinity...