aluminum

Summary

Summary: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.

Top Publications

  1. ncbi Aluminum as a toxicant
    A Becaria
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, Irvine, CA 92697 1820, USA
    Toxicol Ind Health 18:309-20. 2002
  2. pmc Genetic architecture of aluminum tolerance in rice (Oryza sativa) determined through genome-wide association analysis and QTL mapping
    Adam N Famoso
    Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York, USA
    PLoS Genet 7:e1002221. 2011
  3. pmc Aluminum tolerance in maize is associated with higher MATE1 gene copy number
    Lyza G Maron
    Robert W Holley Center for Agriculture and Health, US Department of Agriculture Agricultural Research Service, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 110:5241-6. 2013
  4. ncbi Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms
    Etsushi Kuroda
    Department of Immunology and Parasitology, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka 807 8555, Japan
    Immunity 34:514-26. 2011
  5. ncbi An aluminum-activated citrate transporter in barley
    Jun Furukawa
    Research Institute for Bioresources, Okayama University, Chuo, Kurashiki, Okayama, 710 0046, Japan
    Plant Cell Physiol 48:1081-91. 2007
  6. ncbi Chemical equilibrium modeling of organic acids, pH, aluminum, and iron in Swedish surface waters
    Carin S Sjöstedt
    Department of Land and Water Resources Engineering, KTH Royal Institute of Technology, Teknikringen, Stockholm, Sweden
    Environ Sci Technol 44:8587-93. 2010
  7. ncbi Transcriptional regulation of aluminium tolerance genes
    Emmanuel Delhaize
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT, 2601, Australia
    Trends Plant Sci 17:341-8. 2012
  8. ncbi The identification of aluminium-resistance genes provides opportunities for enhancing crop production on acid soils
    P R Ryan
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia
    J Exp Bot 62:9-20. 2011
  9. ncbi An Al-inducible MATE gene is involved in external detoxification of Al in rice
    Kengo Yokosho
    Institute of Plant Science and Resources, Okayama University, Chuo 2 20 1, Kurashiki 710 0046, Japan
    Plant J 68:1061-9. 2011
  10. ncbi Recent progress in the research of external Al detoxification in higher plants: a minireview
    Jian Feng Ma
    Faculty of Agriculture, Kagawa University, Ikenobe 2393, Miki cho, Kita gun, Kagawa 761 0795, Japan
    J Inorg Biochem 97:46-51. 2003

Research Grants

Detail Information

Publications319 found, 100 shown here

  1. ncbi Aluminum as a toxicant
    A Becaria
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, Irvine, CA 92697 1820, USA
    Toxicol Ind Health 18:309-20. 2002
    Although aluminum is the most abundant metal in nature, it has no known biological function. However, it is known that there is a causal role for aluminum in dialysis encephalopathy, microcytic anemia, and osteomalacia...
  2. pmc Genetic architecture of aluminum tolerance in rice (Oryza sativa) determined through genome-wide association analysis and QTL mapping
    Adam N Famoso
    Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York, USA
    PLoS Genet 7:e1002221. 2011
    b>Aluminum (Al) toxicity is a primary limitation to crop productivity on acid soils, and rice has been demonstrated to be significantly more Al tolerant than other cereal crops...
  3. pmc Aluminum tolerance in maize is associated with higher MATE1 gene copy number
    Lyza G Maron
    Robert W Holley Center for Agriculture and Health, US Department of Agriculture Agricultural Research Service, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 110:5241-6. 2013
    ..Here, we describe how copy number variation underlies a rare allele that contributes to maize aluminum (Al) tolerance...
  4. ncbi Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms
    Etsushi Kuroda
    Department of Immunology and Parasitology, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka 807 8555, Japan
    Immunity 34:514-26. 2011
    Particulates such as silica crystal (silica) and aluminum salts (alum) activate the inflammasome and induce the secretion of proinflammatory cytokines in macrophages...
  5. ncbi An aluminum-activated citrate transporter in barley
    Jun Furukawa
    Research Institute for Bioresources, Okayama University, Chuo, Kurashiki, Okayama, 710 0046, Japan
    Plant Cell Physiol 48:1081-91. 2007
    Soluble ionic aluminum (Al) inhibits root growth and reduces crop production on acid soils. Al-resistant cultivars of barley (Hordeum vulgare L...
  6. ncbi Chemical equilibrium modeling of organic acids, pH, aluminum, and iron in Swedish surface waters
    Carin S Sjöstedt
    Department of Land and Water Resources Engineering, KTH Royal Institute of Technology, Teknikringen, Stockholm, Sweden
    Environ Sci Technol 44:8587-93. 2010
    A consistent chemical equilibrium model that calculates pH from charge balance constraints and aluminum and iron speciation in the presence of natural organic matter is presented...
  7. ncbi Transcriptional regulation of aluminium tolerance genes
    Emmanuel Delhaize
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT, 2601, Australia
    Trends Plant Sci 17:341-8. 2012
    ..We focus on recent insights into the transcriptional regulation of these and other genes involved in Al(3+) tolerance and discuss the pathways coordinating their expression in Arabidopsis and rice...
  8. ncbi The identification of aluminium-resistance genes provides opportunities for enhancing crop production on acid soils
    P R Ryan
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia
    J Exp Bot 62:9-20. 2011
    ..Recent developments in this area are summarized and the structure-function of the TaALMT1 protein from wheat is discussed...
  9. ncbi An Al-inducible MATE gene is involved in external detoxification of Al in rice
    Kengo Yokosho
    Institute of Plant Science and Resources, Okayama University, Chuo 2 20 1, Kurashiki 710 0046, Japan
    Plant J 68:1061-9. 2011
    ..Taken together, our results show that OsFRDL4 is an Al-induced citrate transporter localized at the plasma membrane of rice root cells and is one of the components of high Al tolerance in rice...
  10. ncbi Recent progress in the research of external Al detoxification in higher plants: a minireview
    Jian Feng Ma
    Faculty of Agriculture, Kagawa University, Ikenobe 2393, Miki cho, Kita gun, Kagawa 761 0795, Japan
    J Inorg Biochem 97:46-51. 2003
    b>Aluminum (Al) is highly toxic to plant growth. The toxicity is characterized by rapid inhibition of root elongation. However, some plant species and cultivars have evolved some mechanisms for detoxifying Al both internally and externally...
  11. pmc Differential responses of osteoblast lineage cells to nanotopographically-modified, microroughened titanium-aluminum-vanadium alloy surfaces
    Rolando A Gittens
    School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Biomaterials 33:8986-94. 2012
    ....
  12. ncbi Comparative proteome analyses reveal that nitric oxide is an important signal molecule in the response of rice to aluminum toxicity
    Liming Yang
    School of Life Sciences, Jiangsu Key Laboratory for Eco Agriculture Biotechnology around Hongze Lake, Huaiyin Normal University, Huai an223300, China
    J Proteome Res 12:1316-30. 2013
    ..One of the major contributing factors to acidic soil is the presence of soluble aluminum (Al(3+)) ions, but the mechanisms underlying plant responses to Al(3+) toxicity remain elusive...
  13. ncbi Nitric oxide reduces aluminum toxicity by preventing oxidative stress in the roots of Cassia tora L
    You Sheng Wang
    Department of Biochemistry and Molecular Biology, College of Life Science, Nanjing Agricultural University, Nanjing, 210095, PR China
    Plant Cell Physiol 46:1915-23. 2005
    ..In the present study, we investigated the effect of NO on Cassia tora L. plants exposed to aluminum (Al). Plants pre-treated for 12 h with 0...
  14. pmc The relationship between population structure and aluminum tolerance in cultivated sorghum
    Fernanda F Caniato
    Embrapa Maize and Sorghum, Sete Lagoas, Minas Gerais, Brazil
    PLoS ONE 6:e20830. 2011
    Acid soils comprise up to 50% of the world's arable lands and in these areas aluminum (Al) toxicity impairs root growth, strongly limiting crop yield...
  15. ncbi Aluminum welding fume-induced pneumoconiosis
    Mindy J Hull
    School of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Hum Pathol 33:819-25. 2002
    Chronic exposure to high concentrations of fumes during aluminum arc welding causes a severe pneumoconiosis characterized by diffuse pulmonary accumulation of aluminum metal and a corresponding reduction in lung function...
  16. pmc Identification of wild soybean miRNAs and their target genes responsive to aluminum stress
    Qiao Ying Zeng
    State Key Laboratory for Conservation and Utilization of Subtropical Agro bioresources, College of Agriculture, South China Agricultural University, Guangzhou, 510642, China
    BMC Plant Biol 12:182. 2012
    ..However, little information about miRNAs especially miRNAs responsive to aluminum (Al) stress is available in wild soybean.
  17. ncbi Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease
    Jing Zhang
    Department of Pharmacology, Chongqing Medical University, Chongqing, China
    Saudi Med J 30:760-6. 2009
    To investigate the protective effects of the total base from rhizoma coptis chinensis (CTB) and berberine (Ber) on neurodegeneration induced by aluminum overload in rats.
  18. ncbi Use of employer administrative databases to identify systematic causes of injury in aluminum manufacturing
    Keshia M Pollack
    Department of Health Policy and Management, Center for Injury Research and Policy, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21218, USA
    Am J Ind Med 50:676-86. 2007
    ..Employer administrative files are an underutilized source of data in epidemiologic studies of occupational injuries...
  19. pmc A zinc finger transcription factor ART1 regulates multiple genes implicated in aluminum tolerance in rice
    Naoki Yamaji
    Research Institute for Bioresources, Okayama University, Kurashiki 710 0046, Japan
    Plant Cell 21:3339-49. 2009
    b>Aluminum (Al) toxicity is the major limiting factor of crop production on acid soils, but some plant species have evolved ways of detoxifying Al...
  20. pmc The BnALMT1 and BnALMT2 genes from rape encode aluminum-activated malate transporters that enhance the aluminum resistance of plant cells
    Ayalew Ligaba
    Research Institute for Bioresources, Okayama University, Chuo 2 20 1, Kurashiki 710 0046, Japan
    Plant Physiol 142:1294-303. 2006
    The release of organic anions from roots can protect plants from aluminum (Al) toxicity and help them overcome phosphorus (P) deficiency...
  21. ncbi NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant
    A G Besnard
    Université d Orléans and CNRS, Molecular Immunology and Embryology IEM, Orleans, France
    Allergy 66:1047-57. 2011
    ..Using an adjuvant-free model of allergic lung inflammation induced by ovalbumin (OVA), we investigated the role of NLRP3 inflammasome and related it to IL-1R1 signaling pathway...
  22. pmc The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration
    Natalia Vanduyn
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Neurochem 124:147-57. 2013
    b>Aluminum (Al(3+)) is the most prevalent metal in the earth's crust and is a known human neurotoxicant...
  23. ncbi Beryllium sensitivity among workers at a Norwegian aluminum smelter
    A M Nilsen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Am J Ind Med 53:724-32. 2010
    Sensitivity to beryllium was investigated among workers at an aluminum smelter in Norway as a consequence of the findings in an occupational exposure survey.
  24. ncbi Aluminium toxicity and iron homeostasis
    R J Ward
    Unite de Biochimie, Catholique University of Louvain, 1348, Louvain la Neuve, Belgium
    J Inorg Biochem 87:9-14. 2001
    In an animal model of aluminum overload, (aluminium gluconate), the increases in tissue aluminium content were paralleled by elevations of tissue iron in the kidney, liver heart and spleen as well as in various brain regions, frontal, ..
  25. ncbi High transmission and low color cross-talk plasmonic color filters using triangular-lattice hole arrays in aluminum films
    Qin Chen
    Department of Electronics and Electrical Engineering, University of Glasgow, Rankine Building, Glasgow, U K
    Opt Express 18:14056-62. 2010
    Three primary color (red, green and blue) filters consisting of subwavelength triangular-lattice hole arrays in an aluminum film on glass were simulated and fabricated...
  26. ncbi Hydrogen sulfide alleviates aluminum toxicity in germinating wheat seedlings
    Hua Zhang
    School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China
    J Integr Plant Biol 52:556-67. 2010
    ..sulfide (H(2)S) on seed germination and seedling growth was studied in wheat (Triticum) seeds subjected to aluminum (Al(3+)) stress...
  27. ncbi Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production
    Zhihao Wu
    State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Neurobiol Aging 33:199.e1-12. 2012
    The neurotoxicity of aluminum (Al) - the most abundant metal element on earth - has been known for years. However, the mechanism of Al-induced neurodegeneration and its relationship to Alzheimer's disease are still controversial...
  28. ncbi Oligomeric but not monomeric silica prevents aluminum absorption in humans
    R Jugdaohsingh
    Gastrointestinal Laboratory, The Rayne Institute, St Thomas Hospital, London, UK
    Am J Clin Nutr 71:944-9. 2000
    Soluble silica, a ubiquitous component of the diet, may be the natural ligand for dietary aluminum and may prevent its accumulation and toxicity in animals...
  29. pmc How a microbial drug transporter became essential for crop cultivation on acid soils: aluminium tolerance conferred by the multidrug and toxic compound extrusion (MATE) family
    Jurandir V Magalhaes
    Embrapa Maize and Sorghum, Sete Lagoas, Minas Gerais, Brazil
    Ann Bot 106:199-203. 2010
    ..In crop species such as sorghum and barley, members in the multidrug and toxic compound extrusion (MATE) family underlie Al tolerance by a mechanism based on Al-activated citrate release...
  30. ncbi Mortality and cancer experience of Quebec aluminum reduction plant workers. Part 3: monitoring the mortality of workers first employed after January 1, 1950
    Graham W Gibbs
    Safety Health Environment International Consultant Corp, Devon, Alberta, Canada, T9G 1Y1
    J Occup Environ Med 49:1269-87. 2007
    To monitor changes over time in mortality of workers first employed in Quebec aluminum smelters after January 1, 1950 (1951-one cohort).
  31. ncbi A natural mutation-led truncation in one of the two aluminum-activated malate transporter-like genes at the Ma locus is associated with low fruit acidity in apple
    Yang Bai
    Department of Horticulture, New York State Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
    Mol Genet Genomics 287:663-78. 2012
    ..In this study, we identified two aluminum-activated malate transporter-like genes, designated Ma1 and Ma2, as strong candidates of Ma by narrowing down the ..
  32. ncbi The multiple origins of aluminium resistance in hexaploid wheat include Aegilops tauschii and more recent cis mutations to TaALMT1
    Peter R Ryan
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia
    Plant J 64:446-55. 2010
    ..This study provides an example from higher eukaryotes in which perfect tandem repeats are linked with transcriptional regulation and phenotypic change in the context of evolutionary adaptation to a major abiotic stress...
  33. ncbi Role of magnesium in alleviation of aluminium toxicity in plants
    Jayakumar Bose
    School of Earth and Environment, Faculty of Natural and Agricultural Sciences, University of Western Australia, Crawley WA 6009, Australia
    J Exp Bot 62:2251-64. 2011
    ..Future research should concentrate on assessing aluminium toxicity and tolerance in plants with overexpressed or antisense magnesium transporters to increase understanding of the aluminium-magnesium interaction...
  34. ncbi Aluminum triggers broad changes in microRNA expression in rice roots
    J C Lima
    Laboratório de Genomas e Populações de Plantas, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Genet Mol Res 10:2817-32. 2011
    ..In acid soils, aluminum solubility increases, thereby causing severe damage to plants...
  35. ncbi Transgenic barley (Hordeum vulgare L.) expressing the wheat aluminium resistance gene (TaALMT1) shows enhanced phosphorus nutrition and grain production when grown on an acid soil
    Emmanuel Delhaize
    CSIRO Plant Industry, Canberra, ACT 2601, Australia
    Plant Biotechnol J 7:391-400. 2009
    ..These findings demonstrate that an important crop species can be genetically engineered to successfully increase grain production on an acid soil...
  36. ncbi Effects of vitamin E against aluminum neurotoxicity in rats
    V S Nedzvetsky
    Department of Biophysics and Biochemistry, Faculty of Biology, Dnepropetrovsk National University, Ukraine
    Biochemistry (Mosc) 71:239-44. 2006
    The present study examined the protective effects of vitamin E against aluminum-induced neurotoxicity in rats. Wistar rats were given daily aluminum via their drinking water containing 1600 mg/liter aluminum chloride for six weeks...
  37. ncbi Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture
    Walter J Lukiw
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8B8, New Orleans, LA 70112 2272, USA
    J Inorg Biochem 99:1895-8. 2005
    b>Aluminum, the most abundant neurotoxic metal in our biosphere, has been implicated in the etiology of several neurodegenerative disorders including Alzheimer's disease (AD)...
  38. ncbi Physical analysis of the complex rye (Secale cereale L.) Alt4 aluminium (aluminum) tolerance locus using a whole-genome BAC library of rye cv. Blanco
    B J Shi
    Australian Centre for Plant Functional Genomics ACPFG, School of Agriculture, Food and Wine, University of Adelaide, PMB1, Glen Osmond, SA, 5064, Australia
    Theor Appl Genet 119:695-704. 2009
    ..Rye is highly tolerant of aluminum (Al) toxicity, and possesses a complex structure at the Alt4 Al tolerance locus not found at the corresponding ..
  39. ncbi Potential pathogenic role of beta-amyloid(1-42)-aluminum complex in Alzheimer's disease
    Denise Drago
    Department of Biology, University of Padova, Viale G Colombo, 3 35121 Padova, Italy
    Int J Biochem Cell Biol 40:731-46. 2008
    ....
  40. pmc A second mechanism for aluminum resistance in wheat relies on the constitutive efflux of citrate from roots
    Peter R Ryan
    CSIRO Plant Industry, Canberra, Australian Capital Territory 2601, Australia
    Plant Physiol 149:340-51. 2009
    The first confirmed mechanism for aluminum (Al) resistance in plants is encoded by the wheat (Triticum aestivum) gene, TaALMT1, on chromosome 4DL...
  41. ncbi A tonoplast-localized half-size ABC transporter is required for internal detoxification of aluminum in rice
    Chao Feng Huang
    Institute of Plant Science and Resources, Okayama University, Chuo 2 20 1, Kurashiki, Japan
    Plant J 69:857-67. 2012
    Toxic aluminum enters the root cells rapidly, therefore internal detoxification is required. However, the molecular mechanisms underlying this process are poorly understood...
  42. ncbi Aluminum salts in vaccines--US perspective
    Norman W Baylor
    Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Bethesda, MD, USA
    Vaccine 20:S18-23. 2002
    b>Aluminum in the form of aluminum hydroxide, aluminum phosphate or alum has been commonly used as an adjuvant in many vaccines licensed by the US Food and Drug Administration. Chapter 21 of the US Code of Federal Regulations [610...
  43. ncbi Inhibition of nitric oxide synthase (NOS) underlies aluminum-induced inhibition of root elongation in Hibiscus moscheutos
    Qiu Ying Tian
    Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, People s Republic of China
    New Phytol 174:322-31. 2007
    b>Aluminum (Al) is toxic to plants when solubilized into Al(3+) in acidic soils, and becomes a major factor limiting plant growth. However, the primary cause for Al toxicity remains unknown...
  44. ncbi Identification of aluminum-responsive microRNAs in Medicago truncatula by genome-wide high-throughput sequencing
    Lei Chen
    State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, People s Republic of China
    Planta 235:375-86. 2012
    MicroRNAs (miRNAs) play important roles in response of plants to biotic and abiotic stresses. Aluminum (Al) toxicity is a major factor limiting plant growth in acidic soils...
  45. ncbi Nanobiohybrids as delivery vehicles for camptothecin
    Katherine M Tyner
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
    J Control Release 95:501-14. 2004
    ..The negatively charged micelles were then encapsulated in nanoparticles of magnesium-aluminum layered double hydroxides (LDHs) by an ion exchange process...
  46. pmc AtALMT1, which encodes a malate transporter, is identified as one of several genes critical for aluminum tolerance in Arabidopsis
    Owen A Hoekenga
    Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 103:9738-43. 2006
    b>Aluminum (Al) tolerance in Arabidopsis is a genetically complex trait, yet it is mediated by a single physiological mechanism based on Al-activated root malate efflux...
  47. ncbi Aligned single-crystalline Si nanowire arrays for photovoltaic applications
    Kuiqing Peng
    Department of Materials Sciences and Engineering, Tsinghua University, Beijing, 100084, PR China
    Small 1:1062-7. 2005
  48. ncbi Aluminium as a risk factor in Alzheimer's disease, with emphasis on drinking water
    T P Flaten
    Department of Chemistry, Norwegian University of Science and Technology, Trondheim, Norway
    Brain Res Bull 55:187-96. 2001
    ....
  49. ncbi Two functionally distinct members of the MATE (multi-drug and toxic compound extrusion) family of transporters potentially underlie two major aluminum tolerance QTLs in maize
    Lyza G Maron
    Robert W Holley Center for Agriculture and Health, USDA Agricultural Research Service, Cornell University, Ithaca, NY 14853, USA
    Plant J 61:728-40. 2010
    Crop yields are significantly reduced by aluminum (Al) toxicity on acidic soils, which comprise up to 50% of the world's arable land...
  50. ncbi Identification and mapping of the QTL for aluminum tolerance introgressed from the new source, Oryza Rufipogon Griff., into indica rice (Oryza sativa L.)
    Bay D Nguyen
    Plant Molecular Genetics Laboratory, Plant and Soil Science Department, Texas Tech University, Lubbock 79409, USA
    Theor Appl Genet 106:583-93. 2003
    ..Positional cloning of such QTLs introgressed from O. rufipogon will provide a better understanding of the Al tolerance mechanism in rice and the evolutionary genetics of plant adaptation to acid-soil conditions across cereal species...
  51. pmc Development of a novel aluminum tolerance phenotyping platform used for comparisons of cereal aluminum tolerance and investigations into rice aluminum tolerance mechanisms
    Adam N Famoso
    Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York 14853 1901, USA
    Plant Physiol 153:1678-91. 2010
    The genetic and physiological mechanisms of aluminum (Al) tolerance have been well studied in certain cereal crops, and Al tolerance genes have been identified in sorghum (Sorghum bicolor) and wheat (Triticum aestivum)...
  52. ncbi Differential Al resistance and citrate secretion in barley (Hordeum vulgare L.)
    Zhuqing Zhao
    Faculty of Agriculture, Kagawa University, Ikenobe 2393, Miki cho, Kita gun, 761 0795 Kagawa, Japan
    Planta 217:794-800. 2003
    ..The activity of citrate synthase was unaffected by Al in both Al-resistant and Al-sensitive varieties. The secretion rate of organic acid anions from barley was the lowest among wheat, rye and triticale...
  53. pmc An ALMT1 gene cluster controlling aluminum tolerance at the Alt4 locus of rye (Secale cereale L)
    N C Collins
    Australian Centre for Plant Functional Genomics, School of Agriculture, Food and Wine, University of Adelaide, Glen Osmond, SA 5064, Australia
    Genetics 179:669-82. 2008
    b>Aluminum toxicity is a major problem in agriculture worldwide. Among the cultivated Triticeae, rye (Secale cereale L.) is one of the most Al tolerant and represents an important potential source of Al tolerance for improvement of wheat...
  54. pmc STOP1 regulates multiple genes that protect arabidopsis from proton and aluminum toxicities
    Yoshiharu Sawaki
    Laboratory of Plant Cell Technology, Faculty of Applied Biological Sciences, Gifu University, Gifu 501 1193, Japan
    Plant Physiol 150:281-94. 2009
    ..were down-regulated in the mutant, indicating that STOP1 is involved in signal transduction pathways regulating aluminum (Al)- and H(+)-responsive gene expression...
  55. pmc An ATP and oxalate generating variant tricarboxylic acid cycle counters aluminum toxicity in Pseudomonas fluorescens
    Ranji Singh
    Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada
    PLoS ONE 4:e7344. 2009
    ..AGODH) led to the enhanced synthesis of oxalate, a dicarboxylic acid involved in the immobilization of aluminum (Al)...
  56. ncbi Proteome changes induced by aluminium stress in tomato roots
    Suping Zhou
    Department of Agricultural Sciences, School of Agriculture and Consumer Sciences, Tennessee State University, Nashville, TN 37209, USA
    J Exp Bot 60:1849-57. 2009
    ..Other induced proteins were isovaleryl-CoA dehydrogenase and the GDSL-motif lipase hydrolase family protein. NADPH-dependent flavin reductase and beta-hydroxyacyl-ACP dehydratase were suppressed...
  57. doi Use of soy protein-based formulas in infant feeding
    Jatinder Bhatia
    Pediatrics 121:1062-8. 2008
    ..This report reviews the limited indications and contraindications of soy formulas. It will also review the potential harmful effects of soy protein-based formulas and the phytoestrogens contained in these formulas...
  58. pmc Engineering greater aluminium resistance in wheat by over-expressing TaALMT1
    Jorge F Pereira
    Embrapa Trigo, Rodovia BR 285 km 294, Passo Fundo, RS, Brazil
    Ann Bot 106:205-14. 2010
    ..Soil acidity is a major abiotic stress that limits plant production worldwide. The goal of this study was to enhance the acid soil tolerance of wheat by increasing its resistance to Al(3+) toxicity...
  59. ncbi Aluminum rapidly depolymerizes cortical microtubules and depolarizes the plasma membrane: evidence that these responses are mediated by a glutamate receptor
    Mayandi Sivaguru
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211 7400, USA
    Plant Cell Physiol 44:667-75. 2003
    Efforts to understand how plants respond to aluminum have focused on describing the symptoms of toxicity and elucidating mechanisms of tolerance; however, little is known about the signal transduction steps that initiate the plant's ..
  60. pmc Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo
    Michael W Munks
    Department of Immunology, Howard Hughes Medical Institute, Denver, CO 80206, USA
    Blood 116:5191-9. 2010
    It has been recognized for nearly 80 years that insoluble aluminum salts are good immunologic adjuvants and that they form long-lived nodules in vivo...
  61. pmc Improved 18F labeling of peptides with a fluoride-aluminum-chelate complex
    William J McBride
    Immunomedics, Inc, Morris Plains, New Jersey 07950, USA
    Bioconjug Chem 21:1331-40. 2010
    ..The IMP467 peptide could be labeled up to 115 GBq/micromol (3100 Ci/mmol), with a total reaction and purification time of 30 min without chromatographic purification...
  62. ncbi Aluminum: impacts and disease
    Prasunpriya Nayak
    Department of Physiology, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, Gangtok, 737102, Sikkim, India
    Environ Res 89:101-15. 2002
    b>Aluminum is the most widely distributed metal in the environment and is extensively used in modern daily life. Aluminum enters into the body from the environment and from diet and medication...
  63. pmc The Arabidopsis cell cycle checkpoint regulators TANMEI/ALT2 and ATR mediate the active process of aluminum-dependent root growth inhibition
    Cynthia D Nezames
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    Plant Cell 24:608-21. 2012
    b>Aluminum (Al) toxicity is a global issue that severely limits root growth in acidic soils...
  64. pmc Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite
    Farahnaz Barahuie
    Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology ITMA, Universiti Putra Malaysia, Serdang, Malaysia
    Int J Nanomedicine 8:1975-87. 2013
    In the study reported here, magnesium/aluminum (Mg/Al)-layered double hydroxide (LDH) was intercalated with an anticancer drug, protocatechuic acid, using ion-exchange and direct coprecipitation methods, with the resultant products ..
  65. ncbi Alleviation of aluminum toxicity by hydrogen sulfide is related to elevated ATPase, and suppressed aluminum uptake and oxidative stress in barley
    Muhammad Dawood
    Department of Agronomy, College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou 310058, PR China
    J Hazard Mater 209:121-8. 2012
    ..These data suggest that H(2)S-induced alleviation in Al toxicity is attributed to reduced Al uptake and MDA accumulation, improved uptake of P, Ca, Mg and Fe, and elevated ATPase and photosynthetic performance...
  66. ncbi Nonmalignant mortality among workers in six Norwegian aluminum plants
    P Romundstad
    The Cancer Registry of Norway, Oslo
    Scand J Work Environ Health 26:470-5. 2000
    This study investigated the associations between exposure to fluorides and polycyclic aromatic hydrocarbons (PAH) and mortality from nonmalignant diseases among workers in the Norwegian primary aluminum industry.
  67. ncbi Syntheses of 2-nitroimidazole derivatives conjugated with 1,4,7-triazacyclononane-N,N'-diacetic acid labeled with F-18 using an aluminum complex method for hypoxia imaging
    Lathika Hoigebazar
    Radiation Applied Life Sciences, Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Med Chem 55:3155-62. 2012
    ..In conclusion, (18)F-labeled NODA-nitroimidazole conjugates were developed and proved to be promising hypoxia PET agents...
  68. ncbi Benign joining of ultrafine grained aerospace aluminum alloys using nanotechnology
    Rémi Longtin
    Empa, Swiss Federal Laboratories for Materials Science and Technology, Dubendorf, Switzerland
    Adv Mater 23:5812-6. 2011
    Ultrafine grained aluminum alloys have restricted applicability due to their limited thermal stability. Metalized 7475 alloys can be soldered and brazed at room temperature using nanotechnology...
  69. ncbi Aluminum and Alzheimer's disease: after a century of controversy, is there a plausible link?
    Lucija Tomljenovic
    Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
    J Alzheimers Dis 23:567-98. 2011
    ..b>Aluminum (Al) is the most abundant neurotoxic metal on earth, widely bioavailable to humans and repeatedly shown to ..
  70. ncbi Deep-UV surface-enhanced resonance Raman scattering of adenine on aluminum nanoparticle arrays
    Shankar K Jha
    Laboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, 8093 Zurich, Switzerland
    J Am Chem Soc 134:1966-9. 2012
    We report the ultrasensitive detection of adenine using deep-UV surface-enhanced resonance Raman scattering on aluminum nanostructures...
  71. ncbi Conostegia xalapensis (Melastomataceae): an aluminum accumulator plant
    Iris Hayde González-Santana
    Laboratorio de Alelopatía, Departamento de Ecologia Funcional, Instituto de Ecologia, UNAM, Circuito exterior s n anexo al Jardín Botánico Exterior, Ciudad Universitaria, Delegacion Coyoacan, C P 04510, Mexico D F, Mexico
    Physiol Plant 144:134-45. 2012
    ..C. xalapensis is an Al-accumulator plant that can grow in acidic soils with higher Al³⁺ concentrations, and can be considered as an indicator species for soils with potential Al toxicity...
  72. ncbi Aluminium, antiperspirants and breast cancer
    P D Darbre
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, The University of Reading, P O Box 228, Whiteknights, Reading, RG6 6AJ, UK
    J Inorg Biochem 99:1912-9. 2005
    ....
  73. ncbi Role of exudation of organic acids and phosphate in aluminum tolerance of four tropical woody species
    Nguyen Tran Nguyen
    Graduate School of Biosphere Sciences, Hiroshima University, Hiroshima 739 8528, Japan
    Tree Physiol 23:1041-50. 2003
    ..L., Melaleuca cajuputi Powell, Acacia auriculiformis A. Cunn. ex Benth. and Eucalyptus camaldulensis Dehnh. to aluminum (Al) toxicity at low pH are poorly understood...
  74. ncbi Aluminum decreases the glutathione regeneration by the inhibition of NADP-isocitrate dehydrogenase in mitochondria
    Keiko Murakami
    Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    J Cell Biochem 93:1267-71. 2004
    Effect of aluminum on the NADPH supply and glutathione regeneration in mitochondria was analyzed. Reduced glutathione acted as a principal scavenger of reactive oxygen species in mitochondria...
  75. ncbi Neurobehavioral toxic effects of perinatal oral exposure to aluminum on the developmental motor reflexes, learning, memory and brain neurotransmitters of mice offspring
    Gasem M Abu-Taweel
    Department of Biology, College of Education, Dammam University, P O Box 2375, Dammam 31451, Saudi Arabia
    Pharmacol Biochem Behav 101:49-56. 2012
    b>Aluminum (Al) is a known neurotoxicant and circumstantial evidence has linked this metal with several neurodegenerative disorders like Alzheimer's disease, but no causal relationship has yet been proved...
  76. pmc Antagonistic actions of boron against inhibitory effects of aluminum toxicity on growth, CO2 assimilation, ribulose-1,5-bisphosphate carboxylase/oxygenase, and photosynthetic electron transport probed by the JIP-test, of Citrus grandis seedlings
    Huan Xin Jiang
    Institute of Horticultural Plant Physiology, Biochemistry and Molecular Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China
    BMC Plant Biol 9:102. 2009
    Little information is available on the amelioration of boron (B) on aluminum (Al)-induced photosynthesis inhibition. Sour pummelo (Citrus grandis) seedlings were irrigated for 18 weeks with nutrient solution containing 4 B levels (2...
  77. ncbi Mechanisms of aluminum-tolerance in two species of citrus: secretion of organic acid anions and immobilization of aluminum by phosphorus in roots
    Lin Tong Yang
    Institute of Horticultural Plant Physiology, Biochemistry and Molecular Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China
    Plant Sci 180:521-30. 2011
    ..2 mM AlCl₃ · 6H₂O (+Al) x 0, 50 and 200 μM KH₂PO₄. C. sinensis was more tolerant to aluminum (Al) than C. grandis. Phosphorus (P) alleviated the toxic effects of Al on seedlings...
  78. ncbi Protective effects of Ginkgo biloba leaf extract on aluminum-induced brain dysfunction in rats
    Qi Hai Gong
    Department of Pharmacology, Zunyi Medical College, Zunyi, Guizhou, 563003, P R of China
    Life Sci 77:140-8. 2005
    This study examined the protective effects of Ginkgo biloba extract (GbE) on the learning and memory function in aluminum-treated rats and potential mechanisms. Wistar rats were given daily aluminum chloride 500 mg/kg, i...
  79. ncbi Induction of callose in roots of Norway spruce seedlings after short-term exposure to aluminum
    Yasuhiro Hirano
    Swiss Federal Institute for Forest, Snow and Landscape Research WSL, CH 8903 Birmensdorf, Switzerland
    Tree Physiol 24:1279-83. 2004
    Callose (1,3-beta-glucan) is a suggested physiological indicator of aluminum (Al) toxicity in crop plants...
  80. ncbi Overexpression of Citrus junos mitochondrial citrate synthase gene in Nicotiana benthamiana confers aluminum tolerance
    Wei Deng
    Key Laboratory of Functional Gene and Regulation Technologies under Chongqing Municipal Education Commission, Genetic Engineering Research Center, Bioengineering College, Chongqing University, People s Republic of China
    Planta 230:355-65. 2009
    b>Aluminum (Al) toxicity is one of the major factors that limit plant growth in acid soils. Al-induced release of organic acids into rhizosphere from the root apex has been identified as a major Al-tolerance mechanism in many plant species...
  81. ncbi Molecular and physiological strategies to increase aluminum resistance in plants
    Claudio Inostroza-Blancheteau
    Programa de Doctorado en Ciencias de Recursos Naturales, Departamento de Ciencias Químicas y Recursos Naturales, Universidad de La Frontera, Casilla 54 D, Temuco, Chile
    Mol Biol Rep 39:2069-79. 2012
    b>Aluminum (Al) toxicity is a primary limitation to plant growth on acid soils...
  82. ncbi Mechanism for the detoxification of aluminum in roots of tea plant (Camellia sinensis (L.) Kuntze)
    Akio Morita
    Shizuoka University, 836 Ohya Suruga ku, Shizuoka shi, Shizuoka 422 8529, Japan
    Phytochemistry 69:147-53. 2008
    To determine the mechanism of aluminum (Al) detoxification in the roots of tea plants (Camellia sinensis (L...
  83. pmc A dipping duration study for optimization of anodized-aluminum pressure-sensitive paint
    Hirotaka Sakaue
    Aerospace Research and Development Directorate, Japan Aerospace Exploration Agency Chofu, Tokyo 182 8522, Japan
    Sensors (Basel) 10:9799-807. 2010
    Anodized-aluminum pressure-sensitive paint (AA-PSP) uses the dipping deposition method to apply a luminophore on a porous anodized-aluminum surface...
  84. ncbi Aluminum in the diet and Alzheimer's disease: from current epidemiology to possible disease-modifying treatment
    Vincenza Frisardi
    Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy
    J Alzheimers Dis 20:17-30. 2010
    ..In particular, aluminum (Al) neurotoxicity was suggested after its discovery in the senile plaques and neurofibrillary tangles that ..
  85. pmc Genotypic differences in Al resistance and the role of cell-wall pectin in Al exclusion from the root apex in Fagopyrum tataricum
    Jian Li Yang
    Key Laboratory of Conservation Biology for Endangered Wildlife, Ministry of Education and State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China
    Ann Bot 107:371-8. 2011
    ..This study aims to investigate genotypic differences among eight cultivars of tatary buckwheat (Fagopyrum tataricum) for Al resistance and explore the possible mechanisms of Al resistance...
  86. pmc Phosphorus and aluminum interactions in soybean in relation to aluminum tolerance. Exudation of specific organic acids from different regions of the intact root system
    Hong Liao
    Root Biology Center, South China Agricultural University, Guangzhou 510642, China
    Plant Physiol 141:674-84. 2006
    b>Aluminum (Al) toxicity and phosphorus (P) deficiency often coexist in acid soils that severely limit crop growth and production, including soybean (Glycine max)...
  87. ncbi Determination of aluminum and zinc in Iranian consumed tea
    M Ahmadi Moghaddam
    Center for Environmental Research, Medical Sciences University of Tehran, Tehran, Iran
    Environ Monit Assess 144:23-30. 2008
    To determine aluminum and zinc in Iranian consumed tea, 31 tea samples were analysed for Al and Zn concentration of tea leaves and tea infusion. The results show that average concentration of Al and Zn in tea leaves was 326 and 50.7 mg...
  88. ncbi Comparative activity of biodegradable nanoparticles with aluminum adjuvants: antigen uptake by dendritic cells and induction of immune response in mice
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 0544, Japan
    Immunol Lett 140:36-43. 2011
    ..dendritic cells (DCs) and subsequent induction of antigen-specific immune responses in mice and compared with aluminum (AL) adjuvants...
  89. ncbi Effects of different protocol doses of low power gallium-aluminum-arsenate (Ga-Al-As) laser radiation (650 nm) on carrageenan induced rat paw ooedema
    R Albertini
    Research Group of Fluorescence, IP and D UNIVAP R, Shishima Hifumi, 2911, 12244 000 Sao Jose dos Campos, SP, Brazil
    J Photochem Photobiol B 74:101-7. 2004
    ..Our results suggest that low power laser irradiation possibly exerts its anti-inflammatory effects by stimulating the release of adrenal corticosteroid hormones...
  90. ncbi A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimer's disease
    Ryong Woon Shin
    Department of Neurological Science, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai 980 8575, Japan
    Brain Res 961:139-46. 2003
    b>Aluminum (Al(III)) and iron (Fe(III)) are reported to accumulate in neurofibrillary tangles of the Alzheimer's disease (AD) brain...
  91. ncbi The response of high and low polyamine-producing cell lines to aluminum and calcium stress
    Sridev Mohapatra
    Department of Biological Sciences, University of New Hampshire, Durham, NH 03824, USA
    Plant Physiol Biochem 48:612-20. 2010
    ....
  92. ncbi Aluminum-triggered structural modifications and aggregation of beta-amyloids
    F Ricchelli
    CNR Institute of Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, Viale G Colombo, 3 35121, Padova, Italy
    Cell Mol Life Sci 62:1724-33. 2005
    ..Al3+ effects were abolished by desferrioxamine mesylate (DFO) only in solution. We concluded that, in vivo, DFO may act as a protective agent by preventing or reverting Abeta aggregation in the extracellular spaces...
  93. pmc Transcriptomic analysis reveals differential gene expression in response to aluminium in common bean (Phaseolus vulgaris) genotypes
    Dejene Eticha
    Institute of Plant Nutrition, Leibniz University Hannover, Herrenhaeuser Str 2, 30419 Hannover, Germany
    Ann Bot 105:1119-28. 2010
    ..The aims of this study were to identify Al-induced differentially expressed genes and to analyse the expression of candidate genes conferring Al resistance in bean...
  94. ncbi Aluminum accumulation and membrane fluidity alteration in synaptosomes isolated from rat brain cortex following aluminum ingestion: effect of cholesterol
    Virgília S Silva
    Centro de Estudos do Ambiente e Mar, Departamento de Biologia, Universidade de Aveiro, 3810 193 Aveiro, Portugal
    Neurosci Res 44:181-93. 2002
    In the present work, we studied the effect of cholesterol/phospholipid (CH/PL) molar ratio on aluminum accumulation and aluminum-induced alteration of membrane fluidity in rat brain cortex synaptosomes...
  95. ncbi Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity
    Silvia Bolognin
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Int J Biochem Cell Biol 43:877-85. 2011
    ..that are formed upon reacting Aβ with several biometals, namely copper, zinc, iron, and with non-physiological aluminum to assess whether different metal ions are able to differently drive Aβ aggregation...
  96. ncbi A molecular mechanism of aluminium-induced Alzheimer's disease?
    C Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Department of Chemistry, Keele University, Staffordshire, UK
    J Inorg Biochem 76:133-40. 1999
    ..This mechanism involves the potentiation of the activities of neurotransmitters by the action of Al-ATP at adenosine 5'-triphosphate (ATP) receptors in the brain...
  97. ncbi Sclerosing effect of OC-108, a novel agent for hemorrhoids, is associated with granulomatous inflammation induced by aluminum
    Takashi Ono
    Pharmaceuticals Research Unit, Research and Development Division, Mitsubishi Pharma Corporation, Japan
    J Pharmacol Sci 99:353-63. 2005
    OC-108 is a novel sclerosing agent for hemorrhoids, containing aluminum potassium sulfate (alum) and tannic acid as its main ingredients...
  98. ncbi Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain
    Angelica Becaria
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, University of California, Irvine, Irvine, CA 92697 1825, USA
    J Neuroimmunol 176:16-23. 2006
    ..It has been reported that in animal models of AD, exposure to aluminum (Al) or copper (Cu) enhanced oxidative events and accumulation of amyloid beta (Abeta) peptides...
  99. ncbi Genome-wide screening of aluminum tolerance in Saccharomyces cerevisiae
    Masayuki Kakimoto
    Department of Applied Biological Chemistry, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biometals 18:467-74. 2005
    ..The genes for protein mannosylation are also associated with Al tolerance, demonstrating the importance of cell wall architecture. These genes are involved in cell integrity processes...
  100. ncbi Aluminum-induced apoptosis in cultured astrocytes and its effect on calcium homeostasis
    G W Guo
    2nd Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 294 Taiyuan Road, 200031, Shanghai, PR China
    Brain Res 888:221-226. 2001
    b>Aluminum exposure and apoptotic cell death has been implicated in several neurodegenerative conditions including Alzheimer's disease...
  101. ncbi Aluminum taken up by transferrin-independent iron uptake affects the iron metabolism in rat cortical cells
    S Oshiro
    Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University
    J Biochem 123:42-6. 1998
    ..It is also known that in experimental animals fed aluminum (Al), Al at micromolar level selectively accumulates in the brain...

Research Grants62

  1. Intra-operative confocal imaging to guide Mohs surgery
    Milind Rajadhyaksha; Fiscal Year: 2012
    ..feasibility for detecting basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) margins on patients, using aluminum chloride as a contrast agent for staining nuclear morphology in reflectance...
  2. Regulation of Bone Mineralization in Renal Osteodystrophy
    ISIDRO BENJAMIN SALUSKY; Fiscal Year: 2012
    ..as having "high or normal bone turnover" also have alterations in bone mineralization, in the absence of aluminum toxicity, that are present in addition to their primary bone histomorphometric findings...
  3. Waterpipe tobacco smoke: toxicant exposure and effects
    THOMAS EVAN EISSENBERG; Fiscal Year: 2012
    ..to smoke tobacco: the smoker fills the "head" with sweetened and flavored tobacco, covers it with perforated aluminum foil, and tops the foil with lit charcoal...
  4. New drug VS-501 for treating hyperphosphatemia in chronic kidney disease
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..for the calcium-free phosphate binders, and (4) side effects and safety concerns such as hypercalcemia, aluminum toxication, negative influence on other medication, gastrointestinal (GI) side effects and accumulation in organs...
  5. Adjuvant Enhanced Antiviral Immunity
    JEFF C FAIRMAN; Fiscal Year: 2011
    ..administered trivalent inactivated vaccine (TIV) are administered either unadjuvanted or adjuvanted with aluminum hydroxide (alum)...
  6. Short Wavelength UV Sources for Treatment of Psoriasis
    JOSEPH SMART; Fiscal Year: 2006
    ..This proposal concentrates on the development of LEDs based on aluminum gallium nitride (AlGaN) alloys that can cover a large and useful portion of the UV spectrum...
  7. Fabrication of Denture Frameworks Using Titanium Alloys
    Marie Koike; Fiscal Year: 2010
    ..Pure titanium [commercially pure titanium (CP Ti)] or titanium alloys containing aluminum, vanadium, or both, have been used until now...
  8. Occupational Exposure to PM2.5 and Cardiovascular Disease(CVD)
    MARK RICHARD CULLEN; Fiscal Year: 2013
    ..who has been under intense observation for over a decade as part of the PI's ongoing studies at a major Aluminum Company...
  9. Development of a novel adjuvant for vaccine sparing
    Hao Shen; Fiscal Year: 2013
    ..To date, clinical trials with aluminum-based adjuvants (alum)-the only ones licensed in the U.S...
  10. Sub-Wavelength Imaging of Intracellular Metal Ions
    Joseph R Lakowicz; Fiscal Year: 2010
    ..Depending upon the intended wavelength range the structures will be made out of gold, silver or aluminum, which will extend the wavelength range from the UV to the NIR...
  11. A Microfluidic Device for Label-free HIV Virion Count at Point of Care Settings
    Xuanhong Cheng; Fiscal Year: 2010
    ..our goal of measuring circulating virions directly from plasma, we will rely on functional nanoporous anodic aluminum oxide (AAO) membranes packaged in a microfluidic format to filter, concentrate, capture and detect whole HIV ..
  12. Trehalose-6-phosphate phosphatase: a target for anti-onchocerciasis therapeutics
    Debra Dunaway-Mariano; Fiscal Year: 2013
    ..substrate analog) and transition-state conformations (T6PP and trehalose plus vanadate, beryllium fluoride, or aluminum fluoride)...
  13. Role of the Nlrp3 Inflammasome in Adaptive Immunity
    STEPHANIE CAROLINE EISENBARTH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aluminum adjuvants, typically referred to as "alum", are the most commonly used adjuvants in human and animal vaccines worldwide...
  14. Development of stable and rapidly acting adjuvanted vaccines for biodefense
    ROBERT NEWTON BREY; Fiscal Year: 2013
    ..Most vaccines are formulated in aqueous buffers and suspensions with aluminum salts adjuvants, vaccine immunogens degrade and lose potency (and efficacy)...
  15. Environmental conditions and their impact on host immunity
    Herman F Staats; Fiscal Year: 2013
    ..In recent decades, potential risk factors such as improved living conditions and the use of aluminum (alum)-adjuvanted vaccines have been proposed as being associated with the increased prevalence of allergic ..
  16. HMGB1-Derived Peptides As Vaccine Adjuvants
    Bradley T Messmer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Currently, aluminum compounds and more recently MPL are the only adjuvants approved by the FDA for use in humans in the U.S...
  17. Novel Metabolic Biomarker for Autism Spectrum Disorder
    Charles E Schwartz; Fiscal Year: 2013
    ..use a single row of 8 wells on the customized plates for each individual, covering the rest of the plate with aluminum foil, to preserve the other rows for future tests...
  18. An innovative approach to improve the activity of an aluminum-containing adjuvant
    Zhengrong Cui; Fiscal Year: 2013
    ..b>Aluminum salts, such as aluminum hydroxide, are widely used in various human vaccines...
  19. Boosting Flu Vaccination without Adjuvant Injection
    Mei X Wu; Fiscal Year: 2013
    ..Vaccine adjuvant can significantly reduce vaccine doses or dosages, reducing the cost enormously. Unfortunately, aluminum-based adjuvant, the only FDA-approved, widely used vaccine adjuvant in the US, failed to provide satisfactory ..
  20. Polymer-Based Modular Systems with Nanosensors for DNA/RNA Sequencing
    Steven Allan Soper; Fiscal Year: 2012
    ..The sensing platform is produced from nanowires built using templating methods from anodized aluminum oxide materials and then, electrochemically thinned to the desired diameter (~10 nm)...
  21. Aluminum Oxide Nanoparticles Conjugated to Antigens Potently Induce Tumor Specifi
    TRACI LEIGH HILTON; Fiscal Year: 2013
    ..When aluminum oxide (Al2O3) nanoparticles were compared head to head to alum (Rehydragel(R)), an FDA-approved vaccine adjuvant, ..
  22. Microsystem-based Formation of Recombinant Protein Fibers
    Xiaoyi Wu; Fiscal Year: 2010
    ..An integrated microfluidic system consisting of PDMS-based microchannels and an aluminum micro heater, for local temperature control, will be fabricated for studying SELP fiber formation...
  23. Development of a Next Generation Anthrax Vaccine, dmPA7909
    SUKJOON PARK; Fiscal Year: 2010
    ..generation vaccine is composed of the double-mutant recombinant Bacillus anthracis protective antigen (dmPA), the aluminum adjuvant Alhydrogel(r) and the immunostimulatory oligodeoxynucleotide compound CPG 7909 (Vaxlmmune(tm)) ..
  24. Fundamental Study of Welding Fume Inhalation
    Serap Erdal; Fiscal Year: 2007
    ..electrodes and Metal Inert Gas (MIG) welding using continuous wire applied to mild steel, stainless steel, and aluminum yield combinationswhich are practiced by 70% of the welding population...
  25. BLOOD TISSUE IRON DEPLETION BY EXTRACORPOREAL CHELATOR
    CLARA AMBRUS; Fiscal Year: 1991
    ..colleagues have developed such a device, using polysulfon hollow fiber cartridges with immobilized chelators, for aluminum chelation in dialysis patients...
  26. RECOMBINANT TRYPANOSOMA CRUZI PROTEIN VACCINES
    LOUIS KIRCHHOFF; Fiscal Year: 1991
    ..vaccinated with recombinant proteins using varying dosages and routes of administration, as well as Freund's and aluminum hydroxide as adjuvants, in an effort to establish procedures that elicit an optimal immune response...
  27. IDENTIFYING RISK FACTORS FOR NOISE INDUCED HEARING LOSS
    Peter Rabinowitz; Fiscal Year: 2000
    ..In this study, a large longitudinal data set of noise-exposed workers in an aluminum smelter and coal mine will be assessed and cleaned...
  28. ALUMINUM IN THE EPIDEMIOLOGY OF ALZHEIMER'S DISEASE
    AMY GRAVES; Fiscal Year: 1993
    A case-control study is proposed to investigate the hypothesis that aluminum is etiologically implicated in Alzheimer's disease (AD)...
  29. LuAG:Ce,Zr Scintillators for PET
    KEITH ROZENBURG; Fiscal Year: 2007
    ..Learning from the development of transparent yttrium aluminum garnet (YAG) for lasers and TA&T's own developments of transparent magnesium aluminate among other ..
  30. A novel vaccine/adjuvant for Streptococcus pneumoniae
    M A Westerink; Fiscal Year: 2003
    ..However, mucosal administration of protein and peptide antigens results in poor immune responses. Aluminum-based mineral salts are the only adjuvants currently approved for use in humans by the U.S...
  31. ANTIIDIOTYPE VACCINE THERAPY OF HUMAN COLORECTAL CANCER
    MALAYA CHATTERJEE; Fiscal Year: 2002
    ..active immune response against CEA following an adequate number of immunizations with the Chl anti-Id adsorbed to aluminum hydroxide...
  32. SILICA INDUCED EPITHELIAL INJURY
    Robert Merchant; Fiscal Year: 1991
    ..Pulmonary surfactant can block some of the toxic effects of silica in vitro. The protective mechanism of aluminum will be pursued using the type II cell model, and the role of surfactant as a natural defense will be ..
  33. EPITAXIAL FILM SCINTILLATORS FOR DIGITAL RADIOGRAPHY
    ALEXANDER LEMPICKI; Fiscal Year: 1999
    ..The investigators propose to test the feasibility of developing a transparent scintillator based on lutetium aluminum garnet (cerium doped) for dental X-ray radiography, as further described by their abstract: "We propose to ..
  34. ERYTHROPOIETIN THERAPY IN RENAL FAILURE
    JOSEPH ESCHBACH; Fiscal Year: 1991
    ..suppression: 1) inhibitors retained in uremic sera; 2) hypertransfusion or repetitive red cell transfusions; 3) aluminum (Al) suppression of home synthesis; 4) inappropriate Ep production in the absence of all of the above three ..
  35. METAL CATALYSED ASYMMETRIC DIELS-ALDER REACTIONS
    Brice Bosnich; Fiscal Year: 1991
    ..This proposal is directed at developing chiral catalysts of the elements boron, aluminum, titanium, and tin for the catalytic asymmetric Diels-Alder reaction...
  36. Intra-operative confocal imaging-guided Mohs surgery
    Milind Rajadhyaksha; Fiscal Year: 2006
    ..light backscatter from the surrounding normal dermis), (c) optimum hemostasis methods using either topical aluminum chloride or electrocautery, (d) image understanding by detailed correlation of images to histology; and (2) an ..
  37. TITANIUM BASED VARIABLE MODULUS ORTHODONTIC WIRE
    LAURENCE SCHETKY; Fiscal Year: 1991
    ..Based on preliminary studies of Titanium-Molybdenum-Aluminum and Titanium-Vanadium- Aluminum alloys, it has been shown that an elastic modulus range from 2...
  38. NOVEL IMMUNIZATION STRATEGIES AGAINST ANTHRAX
    LUCY FREYTAG; Fiscal Year: 2006
    ..The current human U.S. anthrax vaccine consists of aluminum hydroxide-adsorbed culture supernatant from a non-encapsulated strain of B. anthracis...
  39. PEAK EXPOSURES IN ALUMINUM SMELTING
    Noah Seixas; Fiscal Year: 2001
    Workers operating aluminum smelting potrooms are at increased risk of asthma and other respiratory conditions, however the etiologic agent(s) have not been determined...
  40. INTERACTIONS BETWEEN ALPHA-SYNUCLEIN/METALS/PESTICIDES
    Donato Di Monte; Fiscal Year: 2003
    ..laboratory indicate that self-aggregation of alpha-synuclein is dramatically enhanced in the presence of either aluminum or the fungicide diethyldithiocarbamate (DDC)...
  41. KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 2000
    ..of known partial pressures and in the presence of other ions such as zinc, magnesium, silicon, copper, cadmium, aluminum, iron, fluoride, phosphoditrate and polypeptides...
  42. HIGH THROUGHPUT GENOME ANALYSIS SYSTEM
    William Marzluff; Fiscal Year: 2001
    ..Application Number: 2 R01 ES07992-06 DESCRIPTION: (Verbatim from the Applicant's Abstract) Aluminum has long been suspected to play a role in several neurological diseases associated with aging, but this linkage ..
  43. BIODEGRADABLE MINERAL MICROSPHERE ADJUVANTS FOR VACCINES
    ELIE NUWAYSER; Fiscal Year: 1999
    The only vaccine adjuvants approved for use in humans are aluminum gels. As aluminum is a toxic compound, even at low levels, reductions in the amount needed for each vaccine dose will be of broad health benefit...
  44. Development of a Debridement Device Using Ice Particles
    LUIZ DA SILVA; Fiscal Year: 2001
    ..Microdermabrasion (MDA) devices, which use fast moving, small, aluminum oxide particles, have proven effective in abrading tissue in a controlled manner...
  45. FERRITIN AND TRANSFERRIN IN CNS AGING & DISEASE
    James Connor; Fiscal Year: 1992
    ..The first metal in addition to iron that we have chosen to examine is aluminum because of the potential through controversial role of aluminum in Alzheimer's disease...
  46. Development of an Oral Anthrax Vaccine
    John Hilfinger; Fiscal Year: 2002
    ..nonencapsulated strain of Bacillus anthracis which produces the protective antigen (PA) and that is adsorbed to aluminum hydroxide (termed anthrax vaccine adsorbed or AVA)...
  47. Vaccine and Magnetic Resonance Imaging Approaches for AD
    Martin Sadowski; Fiscal Year: 2003
    ..In addition, as an alternative to Freund adjuvant, which is too toxic for human use, we propose to use non-toxic, aluminum based adjuvants (which are approved for human use)...
  48. TH1/TH2 IMMUNITY IN YOUNG ADULT AND AGED MICE
    Thomas Forsthuber; Fiscal Year: 2001
    ..response induced in Th2 biased BALB/c and Th1 biased C57BL/6 mice following immunizations with CFA, IFA or aluminum hydroxide, the primary adjuvant used in humans...
  49. Metal processing by dendritic cells and osteoclasts
    Luis Filgueira; Fiscal Year: 2006
    ..b>Aluminum, chromium and titanium will be used as model metals, as they are extensively used in modern daily life and in ..
  50. A MULTIFUNCTIONAL SURGICAL SUPPORT SURFACE
    James Price; Fiscal Year: 2001
    ..pressure management (Xsensor(TM) system), patient stability (video analysis system) and radiolucency (equivalent aluminum thickness)...
  51. Adjuvant discovery: lipid A mimetics
    David Johnson; Fiscal Year: 2009
    ..Currently, aluminum hydroxide/aluminum phosphate (alum) is the only licensed adjuvant for general human use in the United States...
  52. Microcomputed Tomography Device (Scanco UCT40)
    Mary Bouxsein; Fiscal Year: 2004
    ..We have used our system to non-destructively assess the morphology and microarchitecture of porous aluminum foams, human trabecular bone specimens, and a variety of excised bone and tooth specimens from different animals (..
  53. Ultrasensitive Bispecific Antibody Assay for SARS Virus
    Mavanur Suresh; Fiscal Year: 2009
    ..The immunoswab assay will be optimized using the commercially available nasopharyngeal swab with a flexible aluminum shaft for direct detection of SARS virus or its shed antigen using bsMAbs...
  54. Selective Decorporation Agents for NIAID
    Benjamin P Warner; Fiscal Year: 2013
    ..Current GI absorption blocking agents, such as aluminum phosphate, are of low effectiveness, although they are recommended for clinical use...
  55. Adjuvant Development Program
    Nikolai Petrovsky; Fiscal Year: 2012
    ..Currently, aluminum hydroxide/aluminum phosphate (alum) is the only licensed adjuvant for general human use in the United States...
  56. Adjuvant Development Program
    Nikolai Petrovsky; Fiscal Year: 2009
    ..Currently, aluminum hydroxide/aluminum phosphate (alum) is the only licensed adjuvant for general human use in the United States...
  57. Adjuvant Development Program
    Nikolai Petrovsky; Fiscal Year: 2011
    ..Currently, aluminum hydroxide/aluminum phosphate (alum) is the only licensed adjuvant for general human use in the United States...
  58. Adjuvant Development Program
    BRADFORD SEAMON; Fiscal Year: 2011
    ..Currently, aluminum hydroxide/aluminum phosphate (alum) is the only licensed adjuvant for general human use in the United States...
  59. VESTIBULOOCULAR FUNCTION IN NEUROOTOLOGICAL DISORDERS
    Joseph Furman; Fiscal Year: 1992
    ..This unit will be surrounded by a cylindrical aluminum enclosure which will serve as a projection screen for visual targets during visual-vestibular interaction and ..
  60. EMBRYONIC BONE FORMATION DURING ALUMINUM TOXICITY
    CONRAD FIRLING; Fiscal Year: 1990
    The long term objective of this project is to gain information concerning the mechanism(s) by which aluminum causes bone pathology...
  61. Adjuvant Development Program
    LAURA LANGE; Fiscal Year: 2012
    ..Currently, aluminum hydroxide/aluminum phosphate (alum) is the only licensed adjuvant for general human use in the United States...