Summary: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.

Top Publications

  1. pmc Zinc in human health: effect of zinc on immune cells
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, Michigan 48201, United States of America
    Mol Med 14:353-7. 2008
  2. ncbi A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat
    Cristobal Uauy
    Department of Plant Sciences, University of California, One Shields Avenue, Davis, CA 95616, USA
    Science 314:1298-301. 2006
  3. ncbi Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis
    C E Outten
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Science 292:2488-92. 2001
  4. pmc miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells
    Brittany L Mihelich
    Department of Pathology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:44503-11. 2011
  5. pmc Nutritional immunity beyond iron: a role for manganese and zinc
    Thomas E Kehl-Fie
    Vanderbilt University Medical Center, Department of Microbiology and Immunology, USA
    Curr Opin Chem Biol 14:218-24. 2010
  6. ncbi Metal chelation and inhibition of bacterial growth in tissue abscesses
    Brian D Corbin
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 319:962-5. 2008
  7. pmc Zinc and the modulation of redox homeostasis
    Patricia I Oteiza
    Department of Nutrition and Department of Environmental Toxicology, University of California at Davis, Davis, CA 95616, USA
    Free Radic Biol Med 53:1748-59. 2012
  8. pmc Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration
    M Indriati Hood
    Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS Pathog 8:e1003068. 2012
  9. pmc Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages
    Hélène Botella
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    Cell Host Microbe 10:248-59. 2011
  10. ncbi Zinc finger proteins: new insights into structural and functional diversity
    J H Laity
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 11:39-46. 2001

Detail Information

Publications383 found, 100 shown here

  1. pmc Zinc in human health: effect of zinc on immune cells
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, Michigan 48201, United States of America
    Mol Med 14:353-7. 2008
    Although the essentiality of zinc for plants and animals has been known for many decades, the essentiality of zinc for humans was recognized only 40 years ago in the Middle East...
  2. ncbi A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat
    Cristobal Uauy
    Department of Plant Sciences, University of California, One Shields Avenue, Davis, CA 95616, USA
    Science 314:1298-301. 2006
    ..here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content...
  3. ncbi Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis
    C E Outten
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Science 292:2488-92. 2001
    Intracellular zinc is thought to be available in a cytosolic pool of free or loosely bound Zn(II) ions in the micromolar to picomolar range...
  4. pmc miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells
    Brittany L Mihelich
    Department of Pathology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:44503-11. 2011
    Decreased zinc levels are a hallmark of prostate cancer tumors as zinc uniquely concentrates in healthy prostate tissue...
  5. pmc Nutritional immunity beyond iron: a role for manganese and zinc
    Thomas E Kehl-Fie
    Vanderbilt University Medical Center, Department of Microbiology and Immunology, USA
    Curr Opin Chem Biol 14:218-24. 2010
    ..Recent work has demonstrated that in addition to iron, vertebrates sequester zinc and manganese both intracellularly and extracellularly to protect against infection...
  6. ncbi Metal chelation and inhibition of bacterial growth in tissue abscesses
    Brian D Corbin
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 319:962-5. 2008
    ..These results demonstrate that calprotectin is a critical factor in the innate immune response to infection and define metal chelation as a strategy for inhibiting microbial growth inside abscessed tissue...
  7. pmc Zinc and the modulation of redox homeostasis
    Patricia I Oteiza
    Department of Nutrition and Department of Environmental Toxicology, University of California at Davis, Davis, CA 95616, USA
    Free Radic Biol Med 53:1748-59. 2012
    b>Zinc, a redox-inactive metal, has been long viewed as a component of the antioxidant network, and growing evidence points to its involvement in redox-regulated signaling...
  8. pmc Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration
    M Indriati Hood
    Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS Pathog 8:e1003068. 2012
    ..Toward this end, the role for calprotectin- (CP)-mediated chelation of manganese (Mn) and zinc (Zn) in defense against A. baumannii was investigated. These experiments revealed that CP inhibits A...
  9. pmc Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages
    Hélène Botella
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    Cell Host Microbe 10:248-59. 2011
    ..genes encoding heavy metal efflux P-type ATPases CtpC, CtpG, and CtpV, and host cell metallothioneins and zinc exporter ZnT1, were induced during infection...
  10. ncbi Zinc finger proteins: new insights into structural and functional diversity
    J H Laity
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 11:39-46. 2001
    b>Zinc finger proteins are among the most abundant proteins in eukaryotic genomes...
  11. ncbi Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
    Neuron 59:43-55. 2008
    ..The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD...
  12. pmc Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations
    Taiho Kambe
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
    Mol Cell Biol 29:129-39. 2009
    The zinc transporter ZIP4 (SLC39A4) is mutated in humans with the rare, autosomal recessive genetic disease acrodermatitis enteropathica. In mice, this gene is essential during early embryonic development...
  13. pmc A voltage-gated proton-selective channel lacking the pore domain
    I Scott Ramsey
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 440:1213-6. 2006
    ..The data presented here identify H(v)1 as a long-sought voltage-gated H+ channel and establish H(v)1 as the founding member of a family of mammalian VSD proteins...
  14. pmc The neurophysiology and pathology of brain zinc
    Stefano L Sensi
    Department of Neuroscience and Imaging, Molecular Neurology Unit, CeSI Center for Excellence on Aging, University G D Annunzio, Chieti 66013, Italy
    J Neurosci 31:16076-85. 2011
    Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding...
  15. pmc Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation
    Michal Sheffer
    Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
    Oncotarget 2:1191-202. 2011
    ..b>Zinc supplementation has been shown to counteract the hypoxic phenotype in cancer cells, in vitro and in vivo, hence, ..
  16. ncbi Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily
    Carine Bebrone
    Center for Protein Engineering Biological Macromolecules, University of Liege, Allée du 6 Août B6, Sart Tilman 4000 Liège, Belgium
    Biochem Pharmacol 74:1686-701. 2007
    ..In the last few years, many new zinc beta-lactamases have been described and several pathogens are now known to synthesize members of this class...
  17. pmc Zinc homeostasis and signaling in health and diseases: Zinc signaling
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, 230 0045, Japan
    J Biol Inorg Chem 16:1123-34. 2011
    The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems that include growth retardation, immunodeficiency, hypogonadism, and neuronal and sensory ..
  18. ncbi Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs
    Rosa Puca
    National Cancer Institute Regina Elena, Rome, Italy
    Cell Cycle 10:1679-89. 2011
    ..inhibition of DNA binding and transcriptional activities that correlate with increased chemoresistance, and that zinc rescues wild-type p53 activity...
  19. ncbi Metallothionein: the multipurpose protein
    P Coyle
    Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, Adelaide, SA
    Cell Mol Life Sci 59:627-47. 2002
    ..Use of mice with altered gene expression has enhance our understanding of the multifaceted role of MT, emphasised in this review...
  20. ncbi Zinc in the physiology and pathology of the CNS
    Stefano L Sensi
    Department of Basic and Applied Medical Science, Molecular Neurology Unit, CeSI Center for Excellence on Aging, University G dAnnunzio, Chieti, 66013, Italy
    Nat Rev Neurosci 10:780-91. 2009
    The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology...
  21. ncbi Transition metal speciation in the cell: insights from the chemistry of metal ion receptors
    Lydia A Finney
    Department of Chemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Il 60208 3113, USA
    Science 300:931-6. 2003
    ..The different coordination numbers, types of coordinating residues, and solvent accessibilities of these sites are providing insight into the inorganic chemistry of the cytoplasm...
  22. pmc Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
    James A Duce
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria 3052, Australia
    Cell 142:857-67. 2010
    ..Abnormal exchange of cortical zinc may link amyloid pathology with neuronal iron accumulation in AD.
  23. pmc A molecular mechanism for bacterial susceptibility to zinc
    Christopher A McDevitt
    Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia
    PLoS Pathog 7:e1002357. 2011
    Transition row metal ions are both essential and toxic to microorganisms. Zinc in excess has significant toxicity to bacteria, and host release of Zn(II) at mucosal surfaces is an important innate defence mechanism...
  24. pmc A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity
    Jim Geiser
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS Genet 8:e1002766. 2012
    ..loss-of-function of this gene rapidly leads to wasting and death unless mice are nursed or provided excess dietary zinc. An initial effect of the knockout was the reprogramming of Paneth cells, which contribute to the intestinal stem ..
  25. ncbi Molecular mechanisms of metal hyperaccumulation in plants
    Nathalie Verbruggen
    Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    New Phytol 181:759-76. 2009
    ..This review presents key aspects of our current understanding of plant metal – in particular cadmium (Cd),nickel (Ni) and zinc (Zn) – hyperaccumulation.
  26. ncbi Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells
    Weidong Wu
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:28258-63. 2003
    ..Pretreatment of the cells with a proteasome inhibitor significantly blocked zinc-induced reduction of PTEN protein as well as the increase in Akt phosphorylation, implicating the involvement of ..
  27. ncbi Counting the zinc-proteins encoded in the human genome
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019 Sesto Fiorentino, Italy
    J Proteome Res 5:196-201. 2006
    ..proposes a strategy to answer the question of how many and which proteins encoded in the human genome may require zinc for their physiological function...
  28. ncbi Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials
    Kenneth H Brown
    Program in International Nutrition and the Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 75:1062-71. 2002
    Multiple studies have been carried out to assess the effect of zinc supplementation on children's growth. The results of these studies are inconsistent, and the factors responsible for these varied outcomes are unknown.
  29. ncbi Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets
    Bingkun Zhang
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, People s Republic of China
    Br J Nutr 102:687-93. 2009
    ..diet supplemented with 2000 mg Zn/kg from ZnO; (3) control diet supplemented with 2000 mg Zn/kg from tetrabasic zinc chloride (TBZC)...
  30. pmc Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans
    John T Murphy
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 7:e1002013. 2011
    b>Zinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity...
  31. ncbi Impact of the discovery of human zinc deficiency on health
    Ananda S Prasad
    Wayne State University School of Medicine, 1122 Elliman Bldg, 421 East Canfield, Detroit, MI 48201, USA
    J Am Coll Nutr 28:257-65. 2009
    The essentiality of zinc was recognized 46 years ago. Zinc deficiency resulting in growth retardation, hypogonadism, immune dysfunction and cognitive impairment affects nearly 2 billion subjects in the developing world...
  32. ncbi Mammalian zinc transporters
    Juan P Liuzzi
    Nutrition Genomics Laboratory and Center for Nutritional Sciences, University of Florida, Gainesville, Florida, 32611 0370, USA
    Annu Rev Nutr 24:151-72. 2004
    New insights into mammalian zinc metabolism have been acquired through the identification and characterization of zinc transporters...
  33. pmc Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes
    J Miller
    EMBO J 4:1609-14. 1985
    ..The native particle is shown to contain 7-11 zinc atoms. These data suggest that the protein contains repetitive zinc-binding domains...
  34. ncbi Discovery of human zinc deficiency: 50 years later
    Ananda S Prasad
    Wayne State University School of Medicine, Department of Oncology and Barbara Ann Karmanos Cancer Center, Detroit, MI 48201, USA
    J Trace Elem Med Biol 26:66-9. 2012
    Essentiality of zinc for humans and its deficiency was recognized in 1963. During the past 50 years, it has become apparent that deficiency of zinc in humans is prevalent...
  35. ncbi Insight to physiology and pathology of zinc(II) ions and their actions in breast and prostate carcinoma
    J Gumulec
    Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, CZ 62500 Brno, Czech Republic European Union
    Curr Med Chem 18:5041-51. 2011
    b>Zinc(II) ions contribute to a number of biological processes e.g. DNA synthesis, gene expression, enzymatic catalysis, neurotransmission, and apoptosis...
  36. pmc ZntR-mediated transcription of zntA responds to nanomolar intracellular free zinc
    Da Wang
    Program in Chemical Biology and Department of Chemistry, The University of Michigan, 930 N University Ave, Ann Arbor, MI 48109, USA
    J Inorg Biochem 111:173-81. 2012
    In E. coli, ZitB and ZntA are important metal exporters that enhance cell viability under high environmental zinc. To understand their functions in maintaining zinc homeostasis, we applied a novel genetically-encoded fluorescent zinc ..
  37. ncbi Indicators of zinc status at the population level: a review of the evidence
    Rosalind S Gibson
    Department of Hunan Nutrition, University of Otago, Union Street, PO Box 56, Dunedin 9015, New Zealand
    Br J Nutr 99:S14-23. 2008
    The role of zinc deficiency as an important cause of morbidity and impaired linear growth has prompted the need to identify indicators of population zinc status...
  38. ncbi Bacterial zinc uptake and regulators
    Klaus Hantke
    Mikrobiologie Membranphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Curr Opin Microbiol 8:196-202. 2005
    Many bacteria use an ABC transporter for high-affinity uptake of zinc with a cluster 9 solute-binding protein. Other members of this protein family transport manganese...
  39. pmc The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e3642. 2008
    b>Zinc (Zn) is an essential trace element and it is abundant in connective tissues, however biological roles of Zn and its transporters in those tissues and cells remain unknown.
  40. pmc Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA, USA
    Prog Neurobiol 94:296-306. 2011
    ..Although questioned by some, brain copper, zinc, and particularly iron overload are widely accepted features of AD which have led to the hypothesis that oxidative ..
  41. ncbi The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5
    Jodi Dufner-Beattie
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
    J Biol Chem 279:49082-90. 2004
    The ZIP5 gene encodes a protein closely related to ZIP4, a zinc transporter mutated in the human genetic disorder acrodermatitis enteropathica...
  42. pmc Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus
    Thomas E Kehl-Fie
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell Host Microbe 10:158-64. 2011
    By sequestering manganese and zinc, the neutrophil protein calprotectin plays a crucial role in host defense against bacterial and fungal pathogens. However, the essential processes disrupted by calprotectin remain unknown...
  43. ncbi Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus
    K M Call
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Cell 60:509-20. 1990
    ..These include the presence of four zinc finger domains and a region rich in proline and glutamine...
  44. ncbi Concurrent micronutrient deficiencies in lactating mothers and their infants in Indonesia
    M A Dijkhuizen
    Division of Human Nutrition and Epidemiology, Wageningen University, Netherlands
    Am J Clin Nutr 73:786-91. 2001
    BACKGROUND: Deficiencies of vitamin A, iron, and zinc are prevalent worldwide, affecting vulnerable groups such as lactating women and infants. However, the existence of concurrent deficiencies has received little attention...
  45. pmc An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter
    C Thelwell
    Department of Biochemistry and Genetics, The Medical School, University of Newcastle, NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 95:10728-33. 1998
    ..Metal coordination to His-imidazole and Cys-thiolate ligands at these residues of ZiaR is thus implicated in Zn2+-perception by Synechocystis PCC 6803...
  46. ncbi Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR
    Anita Changela
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205Tech Drive, Evanston, IL 60208, USA
    Science 301:1383-7. 2003
    ..This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch...
  47. pmc Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response
    Juan P Liuzzi
    Nutritional Genomics Laboratory, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611, USA
    Proc Natl Acad Sci U S A 102:6843-8. 2005
    ..The latter involves regulation of the iron transporter ferroportin 1 by hepcidin. The mechanism of reduced plasma zinc is not known...
  48. pmc The essential toxin: impact of zinc on human health
    Laura M Plum
    Institute of Immunology, Medical Faculty, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany
    Int J Environ Res Public Health 7:1342-65. 2010
    Compared to several other metal ions with similar chemical properties, zinc is relatively harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a rare event...
  49. ncbi Mammalian zinc transport, trafficking, and signals
    Robert J Cousins
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, Florida 32611 0370, USA
    J Biol Chem 281:24085-9. 2006
  50. ncbi Mechanisms of nutrient modulation of the immune response
    Susanna Cunningham-Rundles
    Host Defenses Program, Department of Pediatrics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY, USA
    J Allergy Clin Immunol 115:1119-28; quiz 1129. 2005
    Lack of adequate macronutrients or selected micronutrients, especially zinc, selenium, iron, and the antioxidant vitamins, can lead to clinically significant immune deficiency and infections in children...
  51. ncbi Zinc and cognitive development
    S Bhatnagar
    All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Br J Nutr 85:S139-45. 2001
    ..b>Zinc deficiency may affect cognitive development by alterations in attention, activity, neuropsychological behavior and ..
  52. ncbi The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice
    Jodi Dufner-Beattie
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
    J Biol Chem 278:33474-81. 2003
    The human ZIP4 gene (SLC39A4) is a candidate for the genetic disorder of zinc metabolism acrodermatitis enteropathica. To understand its role in zinc homeostasis, we examined the function and expression of mouse ZIP4...
  53. ncbi Mammalian zinc transporters: nutritional and physiologic regulation
    Louis A Lichten
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department and Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 2710, USA
    Annu Rev Nutr 29:153-76. 2009
    Research advances defining how zinc is transported into and out of cells and organelles have increased exponentially within the past five years...
  54. pmc Znu is the predominant zinc importer in Yersinia pestis during in vitro growth but is not essential for virulence
    Daniel C Desrosiers
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Infect Immun 78:5163-77. 2010
    ..The Znu ABC transporter is essential for zinc (Zn) uptake and virulence in a number of bacterial pathogens...
  55. pmc A fungal family of transcriptional regulators: the zinc cluster proteins
    Sarah MacPherson
    Department of Microbiology and Immunology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A
    Microbiol Mol Biol Rev 70:583-604. 2006
    The trace element zinc is required for proper functioning of a large number of proteins, including various enzymes. However, most zinc-containing proteins are transcription factors capable of binding DNA and are named zinc finger proteins...
  56. pmc Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut
    Janet Z Liu
    Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697, USA
    Cell Host Microbe 11:227-39. 2012
    ..Calprotectin sequesters essential micronutrient metals such as zinc, thereby limiting their availability to microbes, a process termed nutritional immunity...
  57. ncbi The missing zinc: p53 misfolding and cancer
    Stewart N Loh
    Department of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Metallomics 2:442-9. 2010
    The p53 tumor suppressor is a transcription factor that contains a single zinc ion near its DNA binding interface. Zn(2+) is required for site-specific DNA binding and proper transcriptional activation...
  58. ncbi The ZIP family of metal transporters
    M L Guerinot
    Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
    Biochim Biophys Acta 1465:190-8. 2000
    ..identified in plants, are capable of transporting a variety of cations, including cadmium, iron, manganese and zinc. Information on where in the plant each of the ZIP transporters functions and how each is controlled in response to ..
  59. ncbi The Arabidopsis metal tolerance protein AtMTP3 maintains metal homeostasis by mediating Zn exclusion from the shoot under Fe deficiency and Zn oversupply
    Stéphanie Arrivault
    Max Planck Institute of Molecular Plant Physiology, D 14424 Potsdam, Germany
    Plant J 46:861-79. 2006
    b>Zinc ions are required to maintain the biological activity of numerous proteins...
  60. pmc Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
    Michael McMahon
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland
    Proc Natl Acad Sci U S A 107:18838-43. 2010
  61. ncbi Zinc and human health: an update
    Christos T Chasapis
    Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece
    Arch Toxicol 86:521-34. 2012
    The importance of micronutrients in health and nutrition is undisputable, and among them, zinc is an essential element whose significance to health is increasingly appreciated and whose deficiency may play an important role in the ..
  62. ncbi Zinc coordination sphere in biochemical zinc sites
    D S Auld
    Center for Biochemical and Biophysical Sciences and Medicine and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biometals 14:271-313. 2001
    b>Zinc is known to be indispensable to growth and development and transmission of the genetic message. It does this through a remarkable mosaic of zinc binding motifs that orchestrate all aspects of metabolism...
  63. pmc Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322
    Zhong Ying Mo
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 284:34648-57. 2009
    ..There is considerable evidence showing that zinc, as an essential element that is highly concentrated in brain, is linked to the development or progression of these ..
  64. ncbi Role of nutritional zinc in the prevention of osteoporosis
    Masayoshi Yamaguchi
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322 0001, USA
    Mol Cell Biochem 338:241-54. 2010
    b>Zinc is known as an essential nutritional factor in the growth of the human and animals. Bone growth retardation is a common finding in various conditions associated with dietary zinc deficiency...
  65. pmc Prion protein facilitates uptake of zinc into neuronal cells
    Nicole T Watt
    Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    Nat Commun 3:1134. 2012
    b>Zinc is released into the synaptic cleft upon exocytotic stimuli, although the mechanism for its reuptake into neurons is unresolved. Here we show that the cellular prion protein enhances the uptake of zinc into neuronal cells...
  66. pmc The zinc-responsive regulon of Neisseria meningitidis comprises 17 genes under control of a Zur element
    Marie Christin Pawlik
    University of Wurzburg, Institute for Hygiene and Microbiology, Wurzburg, Germany
    J Bacteriol 194:6594-603. 2012
    b>Zinc is a bivalent cation essential for bacterial growth and metabolism...
  67. ncbi FieF (YiiP) from Escherichia coli mediates decreased cellular accumulation of iron and relieves iron stress
    Gregor Grass
    Institut fur Mikrobiologie, Martin Luther Universität Halle, Kurt Mothes Str 3, Halle 06120, Germany
    Arch Microbiol 183:9-18. 2005
    ..This suggests that FieF is an iron and zinc efflux system, which would be the first example of iron detoxification by efflux in any organism.
  68. pmc The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction
    Wei Zhong
    China Agricultural University, Beijing, China
    Am J Physiol Gastrointest Liver Physiol 298:G625-33. 2010
    ..This study was undertaken to determine whether zinc deficiency is related to the deleterious effects of alcohol on the intestinal barrier...
  69. ncbi Zinc uptake by Streptococcus pneumoniae depends on both AdcA and AdcAII and is essential for normal bacterial morphology and virulence
    Lucie Bayle
    CEA, Institut de Biologie Structurale Jean Pierre Ebel, Grenoble, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    Mol Microbiol 82:904-16. 2011
    b>Zinc is an essential trace metal for living cells. The ABC transporter AdcABC was previously shown to be required for zinc uptake by Streptococcus pneumoniae...
  70. pmc Zinc: an essential but elusive nutrient
    Janet C King
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Am J Clin Nutr 94:679S-84S. 2011
    b>Zinc is essential for multiple aspects of metabolism...
  71. pmc A Campylobacter jejuni znuA orthologue is essential for growth in low-zinc environments and chick colonization
    Lindsay M Davis
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Bacteriol 191:1631-40. 2009
    ..ZnuA (Cj0143c) is the periplasmic component of a putative zinc ABC transport system and is encoded on a zinc-dependent operon with Cj0142c and Cj0141c, which encode the other two ..
  72. ncbi Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis
    Miriam M Cortese
    Institute of Molecular Medicine, Research Group Immunobiology, Medical Faculty of the Heinrich Heine University Düsseldorf, Universitatsstrasse 1, D 40225 Dusseldorf, Germany
    Free Radic Biol Med 44:2002-12. 2008
    ..This study aims to investigate the antioxidant activity exerted by zinc in primary rat endothelial cells (EC)...
  73. pmc Role of ZnuABC and ZinT in Escherichia coli O157:H7 zinc acquisition and interaction with epithelial cells
    Roberta Gabbianelli
    Biotechnology Service of Service for Biotechnology and Animal Welfare, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    BMC Microbiol 11:36. 2011
    b>Zinc is an essential element for all living cells...
  74. pmc The SLC39 family of zinc transporters
    Jeeyon Jeong
    Department of Nutritional Sciences, University of Wisconsin Madison, 1415 Linden Drive, Madison, WI 53706, USA
    Mol Aspects Med 34:612-9. 2013
    b>Zinc is a trace element nutrient that is essential for life. This mineral serves as a cofactor for enzymes that are involved in critical biochemical processes and it plays many structural roles as well...
  75. pmc Antenatal supplementation with folic acid + iron + zinc improves linear growth and reduces peripheral adiposity in school-age children in rural Nepal
    Christine P Stewart
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Clin Nutr 90:132-40. 2009
    ..We previously reported that a randomized controlled trial of antenatal micronutrient supplements in rural Nepal decreased the risk of low birth weight by approximately 15%...
  76. pmc Dietary intakes of zinc and heme iron from red meat, but not from other sources, are associated with greater risk of metabolic syndrome and cardiovascular disease
    Marcia C de Oliveira Otto
    Division of Epidemiology, Human Genetics and EnvFemental Sciences, The University of Texas Health Sciences Center Houston, USA
    J Nutr 142:526-33. 2012
    ..Data provided little support for the associations between specific micronutrients and MetS, T2D, or CVD. However, nutrients consumed in red meat, or red meat as a whole, may increase risk of MetS and CVD...
  77. ncbi The zinc homeostasis network of land plants
    Scott Aleksander Sinclair
    Ruhr University Bochum, Germany
    Biochim Biophys Acta 1823:1553-67. 2012
    The use of the essential element zinc (Zn) in the biochemistry of land plants is widespread, and thus comparable to that in other eukaryotes...
  78. pmc ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration
    R D Palmiter
    Howard Hughes Medical Institute, University of Washington, Seattle 98195 7370, USA
    EMBO J 15:1784-91. 1996
    A cDNA encoding a second zinc transporter (ZnT-2) was isolated from a rat kidney cDNA expression library by complementation of a zinc-sensitive BHK cell line...
  79. ncbi Identification of SLC39A4, a gene involved in acrodermatitis enteropathica
    Sebastien Kury
    Laboratoire d Etude du Polymorphisme de l ADN, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France
    Nat Genet 31:239-40. 2002
    We have characterized the human gene SLC39A4, which encodes a protein with features characteristic of a ZIP zinc transporter...
  80. ncbi Cu/Zn ratios are associated with nutritional status, oxidative stress, inflammation, and immune abnormalities in patients on peritoneal dialysis
    Chih Hung Guo
    Institute of Biomedical Nutrition, Hung Kuang University, Taichung 433, Taiwan, ROC
    Clin Biochem 44:275-80. 2011
    We evaluated the relationship of the plasma copper/zinc (Cu/Zn) ratio with nutritional status, inflammation, oxidative stress, and immune function in peritoneal dialysis patients.
  81. ncbi Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
    Marc Hanikenne
    Max Planck Institute of Molecular Plant Physiology, D 14476 Potsdam, Germany
    Nature 453:391-5. 2008
    ..A. halleri naturally accumulates and tolerates leaf concentrations as high as 2.2% zinc and 0.28% cadmium in dry biomass. On the basis of transcriptomics studies, metal hyperaccumulation in A...
  82. ncbi Think zinc: New roles for zinc in the control of insulin secretion
    Guy A Rutter
    Department of Cell Biology, Imperial College London, UK
    Islets 2:49-50. 2010
    Genome wide association studies have identified the islet-restricted zinc transporter ZnT8 (SLC30A8) as a likely player in the control of insulin secretion and the risk of developing type 2 diabetes...
  83. ncbi Molecular and genetic features of zinc transporters in physiology and pathogenesis
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Metallomics 3:662-74. 2011
    b>Zinc (Zn) is a vital element...
  84. pmc Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury
    C L Lin
    Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Death Differ 18:1651-63. 2011
    ..Thus, acute upstream Zn(2+)(i) chelation at the start of reperfusion and the use of natural products, that is, flavonoids, may be beneficial in the treatment of cardiac I/R injury...
  85. pmc Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
    Tamara J Nicolson
    Section of Cell Biology, Division of Medicine, Imperial College London, London, U K
    Diabetes 58:2070-83. 2009
    b>Zinc ions are essential for the formation of hexameric insulin and hormone crystallization...
  86. ncbi Study on clinical and biochemical toxicity biomarkers in a zinc-lead mine workers
    Ali Akbar Malekirad
    Science and Research Branch, Islamic Azad University IAU, Tehran, Iran
    Toxicol Ind Health 26:331-7. 2010
    The aim of this study was to determine oxidative stress status as well as blood lead (Pb) and zinc (Zn) levels and clinical markers in workers of a Zn-Pb mine...
  87. ncbi A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses
    Atul Deshpande
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 29:4004-15. 2009
    ..The zinc-binding 8-OH-quinoline clioquinol markedly reduced AbetaO synaptic targeting, which was also reduced in brain ..
  88. pmc HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
    Lavinia Nardinocchi
    Department of Experimental Oncology, Molecular Oncogenesis Laboratory, National Cancer Institute Regina Elena, Rome, Italy
    Aging (Albany NY) 3:33-43. 2011
    ..Inhibition of HIF-1α by siRNA, HIF-1α-dominant negative or by zinc re-established the HIPK2 levels and the p53-mediated chemosensitivity in tumor cells...
  89. ncbi Zinc: role in immunity, oxidative stress and chronic inflammation
    Ananda S Prasad
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University, School of Medicine, Detroit, Michigan, USA
    Curr Opin Clin Nutr Metab Care 12:646-52. 2009
    b>Zinc is essential for multiple cellular functions including immunity. Many investigators have used zinc supplementation in an attempt to affect the outcome of various diseases...
  90. ncbi The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency
    Jodi Dufner-Beattie
    Department of Biochemistry and Molecular Biology, University of Virginia School of Medicine, PO Box 800734, Charlottesville, VA 22908, USA
    Hum Mol Genet 16:1391-9. 2007
    The human Zip4 gene (Slc39a4) is mutated in the rare recessive genetic disorder of zinc metabolism acrodermatitis enteropathica, but the physiological functions of Zip4 are not well understood...
  91. ncbi Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
    N Wijesekara
    Department of Physiology, University of Toronto, 1 King s College Circle Room 3352, Toronto, ON, Canada M5S 1A8
    Diabetologia 53:1656-68. 2010
    b>Zinc is highly concentrated in pancreatic beta cells, is critical for normal insulin storage and may regulate glucagon secretion from alpha cells...
  92. ncbi International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control
    Kenneth H Brown
    Program in International Nutrition, University of California, Davis, USA
    Food Nutr Bull 25:S99-203. 2004
  93. ncbi Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule
    Toshio Hirano
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Adv Immunol 97:149-76. 2008
    b>Zinc (Zn) is an essential nutrient required for cell growth, differentiation, and survival, and its deficiency causes growth retardation, immunodeficiency, and other health problems...
  94. pmc Contributions of Zur-controlled ribosomal proteins to growth under zinc starvation conditions
    Scott E Gabriel
    Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
    J Bacteriol 191:6116-22. 2009
    Maintaining intracellular zinc levels is critical, because zinc serves as a cofactor for many required enzymes and is toxic in excess...
  95. ncbi Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence
    Jian Dong
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Biochemistry 42:2768-73. 2003
    ..The results also reveal a direct chemical basis for oxidative damage caused by amyloid-beta protein in AD...
  96. ncbi Preventive zinc supplementation among infants, preschoolers, and older prepubertal children
    Kenneth H Brown
    Department of Nutrition, University of California, Davis, California 95616, USA
    Food Nutr Bull 30:S12-40. 2009
    b>Zinc supplementation trials carried out among children have produced variable results, depending on the specific outcomes considered and the initial characteristics of the children who were enrolled...
  97. ncbi Zinc in plants
    Martin R Broadley
    Plant Sciences Division, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    New Phytol 173:677-702. 2007
    b>Zinc (Zn) is an essential component of thousands of proteins in plants, although it is toxic in excess...
  98. ncbi A comparison of the Thlaspi caerulescens and Thlaspi arvense shoot transcriptomes
    John P Hammond
    Warwick HRI, University of Warwick, Wellesbourne, Warwick CV35 9EF, UK
    New Phytol 170:239-60. 2006
    ..of a robust method to profile and compare the transcriptomes of two nonmodel plant species, Thlaspi caerulescens, a zinc (Zn) hyperaccumulator, and Thlaspi arvense, a nonhyperaccumulator, using Affymetrix Arabidopsis thaliana ATH1-..
  99. pmc Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus
    Limor Besser
    Department of Morphology, Ben Gurion University, Beer Sheva 84105, Israel
    J Neurosci 29:2890-901. 2009
    ..Our results describe a unique role for synaptic Zn(2+) acting as the physiological ligand of a metabotropic receptor and provide a novel pathway by which synaptic Zn(2+) can regulate neuronal function...
  100. ncbi The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli
    S I Patzer
    Mikrobiologie Membranphysiologie, Universitat Tubingen, Germany
    Mol Microbiol 28:1199-210. 1998
    ..This high-affinity transport was energized by ATP. The genes were named znuACB (for zinc uptake; former name yebLMI) and localized at 42 min on the genetic map of E. coli...
  101. pmc Zinc availability regulates exit from meiosis in maturing mammalian oocytes
    Alison M Kim
    Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Chem Biol 6:674-81. 2010
    ..Here we describe major changes in the zinc physiology of the mammalian oocyte as it matures and initiates embryonic development...

Research Grants82

    Bharati Mitra; Fiscal Year: 2010
    ..These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
  2. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..activation and hypercoagulability is the primary cause of the development of pulmonary hypertension, and 6) Zinc supplementation can improve bone health as measured by bone mineral density, bone strength, and markers of bone ..
  3. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..related by sequence comparisons and share significant sequence similarity especially within the two conserved zinc-finger DNA/protein binding domains...
    Paul R Odgren; Fiscal Year: 2012
    ..We will investigate the C-1 domain to determine if it is regulated by diacylglycerol and requires zinc ions for its activity...
  5. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..Abnormal levels of bio-essential metals (iron, copper, and zinc) as well as toxic trace elements (mercury, lead, cadmium, and arsenic) are known to be associated with many health ..
  6. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..Activation of the ARE is mediated by the nuclear transcription factor Nrf2, a zinc-finger protein that turns on a genetic program that stimulates the production of multiple anti-oxidants including ..
  7. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
    ..synthase (NOS) mediated signaling pathways and to determine the roles of nitric oxide (NO)/peroxynitrite (ONOO) and zinc (Zn2+) in UV-induced translation regulation and apoptosis...
  8. BMP signaling in vertebrate development
    Ken W Y Cho; Fiscal Year: 2013
    ..We have identified a critical phylogenetically-conserved transcription factor (Schnurri- related zinc finger protein) mediating BMP signaling through the BRE We propose to address the following specific aims: 1...
  9. Brain Delivery of Nanoformulated Superoxide Dismutase
    Erin G Rosenbaugh; Fiscal Year: 2013
    ..Previous studies have shown that adenoviral-mediated overexpression of the O2O- scavenging enzyme copper/zinc superoxide dismutase (CuZnSOD) attenuates central AngII-dependent cardiovascular dysfunction...
  10. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..events nationwide attributed to 8 trace elements and heavy metals such as copper, sulfur, lead, arsenic, zinc, selenium and 9 phosphorus...
    Juanita L Merchant; Fiscal Year: 2013
    ..During the prior funding cycle, we found that the zinc finger transcription factor ZBP-89 interacts directly with the tumor suppressor protein ataxia telangiectasia ..
  12. Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
    Jakub Tolar; Fiscal Year: 2013
    ..avoid the complications of allogeneic transplants, we are proposing to generate iPSC from EBS-DM patients, and use zinc-finger nuclease (ZFN)-mediated genome editing to inactivate the mutant keratin 14 (KRT14) allele, which is ..
    Vincent W Yang; Fiscal Year: 2013
    ..Our group previously identified a zinc finger- containing transcription factor called Kr[unreadable]ppel-like factor 4 (KLF4;also named gut-enriched Kr[..
  14. Deriving hepatocytes from disease specific iPS to treat metabolic liver disorders
    Namita Roy-Chowdhury; Fiscal Year: 2013
    ..and CN1 patients, (b) correcting the genetic defect by homologous recombination at a genomic "safe harbor", using zinc-finger nuclease or TALE-nuclease technology, and (c) differentiating the genetically corrected iPSCs into ..
  15. Excessive Copper Levels Disrupt Hepatic Nuclear Receptor Function
    Clavia Ruth Wooton-Kee; Fiscal Year: 2011
    ..Wilson's disease is a chronic and severe liver disorder that is fatal if not treated. Chelation and/or zinc therapy started before the onset of severe liver dysfunction has been shown to manage the symptoms of Wilson's ..
  16. Fast accurate ultrasensitive in vitro assay to determine BoNT potency &stability
    ARMIN H REITMAIR; Fiscal Year: 2012
    ..BoNTs are zinc metalloproteases that cleave and inactivate proteins involved in synaptic vesicle fusion and acetylcholine release...
  17. Arsenic co-carcinogenesis with UVR: nitrosation and oxidation of target proteins
    Ke Jian Liu; Fiscal Year: 2013
    ..will test the hypothesis that arsenic-generated reactive oxygen and nitrogen species inhibits the activity of zinc finger DNA repair proteins through reaction with redox-sensitive cysteine residues of the zinc finger domains...
    David J Stillman; Fiscal Year: 2010
    ..The yeast transcription factors Swi5 and Ace2 have nearly identical zinc finger DNA-binding domains, and both factors show similar pattern of cell cycle regulation, being present in the ..
  19. Molecular regulation of GM-CSF expression in alveolar epithelial cells
    Robert Paine; Fiscal Year: 2013
    ..We also have evidence that a zinc finger protein, ZFP36 or tristetraprolin (TTP), may contribute to GM-CSF mRNA degradation...
  20. Transcriptional regulation of proteinuria
    SUMANT SINGH CHUGH; Fiscal Year: 2011
    ..The goal of this proposal is to understand the role of transcriptional factor Zinc Fingers and Homeoboxes 3 (ZHX3) in the pathogenesis of glomerular disease...
  21. Understand and Improve Iron Distribution and Erythropoiesis in Beta-Thalassemia
    Yelena Ginzburg; Fiscal Year: 2013
    ..cells in culture;2) evaluate expression levels and regulators of heme and globin production, measure levels of zinc protoporphyrin and free heme in the cytosol, and characterize the effect on FLVCR and FPN-1B, heme and iron ..
  22. Thrombospondin 4 A1
    JOHN W LAWLER; Fiscal Year: 2010
    ..the adjacent to MIDAS motif will be mutated to alanines to establish the importance of these sites in collagen and zinc binding, and matrix assembly. In addition, the specificity of the MIDAS will be explored using peptide libraries...
  23. Transcriptional Control by the Global Regulator Spx
    PETER A ZUBER; Fiscal Year: 2013
    ..Efficient proteolysis requires YjbH, a zinc-binding protein that interacts with Spx and accelerates ClpXP-catalyzed Spx proteolysis...
  24. Prostate cancer prevention by selenium supplementation
    Rayudu Gopalakrishna; Fiscal Year: 2012
    ..exert their cancer-preventive actions, at least in part, through oxidation of unique cysteine- rich regions and zinc fingers present in protein kinase C (PKC), a known target for a variety of tumor promoters...
  25. Mitochondrial Metabolism and ROS Regulate Lung Cancer
    Navdeep S Chandel; Fiscal Year: 2013
    ..in the cytosol is hydrogen peroxide (H2O2), which is generated by its conversion from superoxide (O2-) by copper-zinc superoxide dismutase (SOD1) in the cytosol...
  26. Alcohol &Antiretrovirals in HIV Infection, Oxidative Stress and Liver Disease
    Marianna K Baum; Fiscal Year: 2012
    ..Plasma antioxidants (glutathione, vitamins A and E, 1 and 2-carotenes, zinc and selenium) will also be determined...
  27. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..cryptoxanthin, cysteine, folate, lutein, lycopene, oleic acid, pro-vitamin A, vitamins C and E, zinc) or promote it (iron, saturated fat);2) methyl group metabolism - betaine, choline, folate, methionine, riboflavin, ..
  28. High-throughput multiplex microsphere screening for toxin protease inhibitors
    Steven W Graves; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The zinc metalloproteases from Botulinum neurotoxin (BoNT) and the Lethal Toxin (LT) of B. anthracis are critical for the toxicity of their host organisms and are excellent pharmaceutical targets...
  29. Cardiac dysfunction in StrepTSS: interplay of SLO and MMPs
    Dennis L Stevens; Fiscal Year: 2013
    ..Matrix metalloproteinases (MMP) are a family of zinc-requiring enzymes that break down structural proteins such as collagen in various types of tissue including the ..
  30. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..In this application, we propose to study the efficacy of zinc or multiple micronutrient supplementation in reducing the risk of infectious diseases and growth faltering among ..
  31. Cardiomyocyte Zinc and its Regulation of Contraction-Relaxation Function
    Bradley M Palmer; Fiscal Year: 2012
    We have made the novel observation that an elevation in intracellular zinc ion concentration ([Zn2+]int) in the isolated cardiomyocyte leads to improved relaxation dynamics...
  32. Role of POZ-zinc finger proteins in tumorigenesis.
    Pier Paolo Pandolfi; Fiscal Year: 2013
    ..In view of the critical role exerted by this protein in tumorigenesis and embryonic development the further elucidation of POKEMON/LRF function and role in human cancer is of great relevance to biomedical research. ..
  33. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..increased sensitivity to modulation by a variety of endogenous agents, including protons, polyamines and zinc. While recent studies have shed light on the roles of KA2-containing kainate receptors in physiological conditions, ..
  34. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..success, we will look for non-carbohydrate hits from three sources: HTS of in-house library, virtual screening of Zinc database, and "binding-site directed lipophilic mining" approach...
  35. Role of the zinc finger transcription factor ZBP89 in blood &vascular developmen
    M Amin Arnaout; Fiscal Year: 2013
    ..In preliminary studies, we have identified the Kruppel-like zinc finger transcription factor ZBP-89 as a master regulator of early development of FLK1+ mesoderm into blood and ..
  36. Computational Design of Small Molecule Drugs Inhibiting the Zinc Finger Transcrip
    David Sherris; Fiscal Year: 2010
    ..of this project is to design small molecules which will inhibit the interaction between VEZF1 (vascular endothelial zinc finger 1) and DNA...
  37. Function of the Zinc Finger Protein ZPR1 in neurodegeneration
    LAXMAN DASS GANGWANI; Fiscal Year: 2013
    ..provided by applicant): The long-term goal of proposed research is to understand the physiological role of zinc finger protein ZPR1 in the pathogenesis of spinal muscular atrophy (SMA) caused by mutation of the survival motor ..
  38. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2013
    ..The long-term goal of this research is to devise molecular sensors for binding, visualizing, and quantifying mobile zinc in neurobiological systems...
  39. Novel endonuclease-targeted approaches to nephroprotection
    Alexei G Basnakian; Fiscal Year: 2013
    ..Specific Aim 1. Determining the efficiency of broad spectrum ROS/endonuclease- targeted kidney protection by zinc-aminothiol chelates. (1A) Testing antioxidant Zn- aminothiol chelates in vitro...
  40. Malaria and the safety of iron interventions: absorption and NTBI
    Gary M Brittenham; Fiscal Year: 2012
    ..ferritin, haptoglobin, and concentrations of pro-(Th-1) and anti-(Th-2) inflammatory cytokines, erythrocyte zinc protoporphyrin, and the complete blood count with absolute reticulocyte count and reticulocyte hemoglobin content (..
  41. Peroxynitrite, nitrotyrosine and HSP90 in neuronal death
    ALVARO G ESTEVEZ; Fiscal Year: 2013
    ..A common phenotype among the ALS-SOD mutations so far investigated is to decrease the affinity for zinc. We have shown that zinc-deficient SOD is both less efficient at scavenging superoxide and a better catalyst of ..
  42. Targeted epigenetic silencing of oncogenic Transcription Factors (PQ18)
    Pilar Blancafort; Fiscal Year: 2013
    ..To direct specific DNAme, we will fuse engineered DNA-binding proteins made of sequence-specific Zinc Finger (ZF) domains with a catalytically active DNA-methyltransferase domain (Dnmt3a)...
  43. Role of p62 in Protein Aggregation and Neurodegeneration in ALS
    Haining Zhu; Fiscal Year: 2009
    ..Protein aggregates containing mutant copper-zinc superoxide dismutase (SOD1) are a hallmark of familial amyotrophic lateral sclerosis (ALS, Lou Gehrig's ..
  44. Causes of rotavirus vaccine failure in Zambian children
    Roma Chilengi; Fiscal Year: 2013
    ..Contributions of HIV infection both in mothers and infants, vitamin A and zinc deficiency, weight for age Z-scores as well as mid upper arm circumference will also be assessed...
    Julian H Lombard; Fiscal Year: 2012
    ..to an increase in vascular oxidative stress resulting from down regulation of antioxidant enzymes such as copper/zinc superoxide dismutase (Cu/Zn SOD), and possibly upregulation of pro- oxidant enzymes...
  46. Genetic Interactions and Synthetic Population Biology
    Michael B Elowitz; Fiscal Year: 2013
    ..This system will be based on zinc finger transcriptional regulation modules in S...
  47. Elucidating the A. baumannii response to calprotectin-mediated zinc starvation
    BRITTANY MORTENSEN; Fiscal Year: 2013
    ..CP also exhibits antimicrobial activity through sequestration of the essential metals zinc (Zn) and manganese (Mn). CP- mediated Zn chelation inhibits A. baumannii growth, and during A...
  48. Structure and Specificity in Metal Ion Homeostasis
    Amy C Rosenzweig; Fiscal Year: 2013
    ..Aberrant handling of metal ions such as copper, zinc, iron, and manganese is linked to numerous human diseases...
  49. Genetic Regulation of Rhombomere Formation
    CHARLES G SAGERSTROM; Fiscal Year: 2013
    ..We will use loss of function approaches (morpholino-mediated knock-down, zinc-finger nuclease-mediated targeted deletions), as well as misexpression approaches (mRNA injections, GAL4:UAS ..
  50. Translating Dosage Compensation to Trisomy
    Jeanne Bentley Lawrence; Fiscal Year: 2010
    ..RNA in chromosome regulation and in technological innovations for induced-pluripotent stem cell (iPSC) programming, zinc finger nuclease (ZFN) genome editing, and non-viral delivery of DNA to cells...
  51. Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilis
    CYNTHIA SEARS; Fiscal Year: 2012
    ..The primary virulence factor of ETBF is a 20 kDa zinc-dependent metalloprotease toxin termed B. fragilis toxin (BFT)...
  52. Low Cost Diagnosis of Disease using Synthetic DNA Reactions
    William L Hughes; Fiscal Year: 2013
    ..A systematic transition will occur from the synthesis, discovery, and characterization of zinc oxide nanostructures for piezoelectric applications towards DNA-based nanotechnology for medical benefit...
  53. Genes Mediating Innate Immune Suppression by Hypercapnia in Mammals and Flies
    PETER H SPORN; Fiscal Year: 2013
    ..The 5 most potent of these candidate CO2-mediators encode the zinc finger homeodomain transcription factor, Zfh2;a histone deactylase;a histone methyltransferase;a chromatin-..
  54. Regulation of tubulogenesis in the Drosophila ovary
    Celeste A Berg; Fiscal Year: 2012
    ..A genetic screen for DA mutants identified the female sterile mutation twin peaks (twk), which disrupts the zinc-finger transcription factor Tramtrack69 (TTK69;French et al. 2003). twk mutants produce short nubs of DAs...
  55. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
    ..4 [KLF4;also called gut-enriched Kr[unreadable]ppel-like factor (GKLF)] was previously identified by our group as a zinc finger-containing transcription factor expressed in the epithelial cells of the gastrointestinal tract...
  56. Soft Metal, Disulfide, and Cysteine Stresses in Escherichia coli
    James A Imlay; Fiscal Year: 2013
    ..Preliminary data demonstrate that silver, mercury, cadmium, and zinc have this effect in vitro, too...
  57. Mechanisms of Perchlorate-Induced Disruption of Sexual Differentiation
    FRANK ARTHUR VON HIPPEL; Fiscal Year: 2013
    ..down expression of NIS and NIS-paralogs with morpholino anti-sense oligonucleotides and induced mutations using zinc finger nucleases (Aim 2b), and gain-of-function experiments by over- expressing the NIS and NIS-paralogs (Aim 2c)...
  58. The amelioration of peroxisomal disorders due to defects in Pex10
    Lee A Niswander; Fiscal Year: 2013
    ..Moreover, we will determine whether the point mutation in the PEX10 zinc RING finger disrupts ubiquitination activity, which could alter recycling of the peroxisomal receptor...
  59. The Role of PcpA in the Mechanism of Virulence and Protective Immunity.
    MELISSA MARIE WALKER; Fiscal Year: 2013
    ..PspA in most strains is regulated through the relative concentrations of both zinc and manganese with the result that it is expressed in invasive disease in the lung, blood and organs;but is not ..
  60. Structure and Function of the Human Beta-Globin Locus Control Region
    JORG BUNGERT; Fiscal Year: 2013
    ..identify cis-regulatory DNA elements that mediate interactions between the LCR and the globin genes we will express zinc finger DNA binding domains that neutralize transcription factor binding sites and examine the effect of these ..
  61. Elevated Zinc in Ischemia and reperfusion
    Yang V Li; Fiscal Year: 2013
    ..Accumulating evidence suggests that another divalent ion zinc (Zn2+) is also involved in excitotoxic neuronal death after head trauma, epilepsy, cerebral ischemia and ..
  62. Development of A Novel Anti-Hyperglycemic Agent
    Zhaoping Li; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): We have demonstrated that a cyclic dipeptide Cyclo (his-pro) plus zinc (Cyclo-Z) treatment improved clinical conditions of diabetes in various animal models and a phase 1 clinical trial...
  63. Pharmaconutrients as Therapies for Critical Illness: Zinc in Severe Sepsis
    Renee D Stapleton; Fiscal Year: 2013
    ..of this proposal is to investigate the pharmacologic behavior and to perform a phase I dose-finding study of zinc in patients with severe sepsis. The biologic rationale for zinc in sepsis is strong...
  64. Dietary Factors Affecting Calcium and Zinc Absorption
    Steven Abrams; Fiscal Year: 2006
    ..We use stable isotope methods that are safe and applicable globally to assess mineral metabolism (calcium, zinc, magnesium, iron, copper)...
  65. Enhancing Dietary Iron and Zinc Bioavailability in Indian Children
    Steven A Abrams; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Background: Iron and zinc deficiencies frequently occur together because the dietary factors that impair iron absorption also affect zinc absorption...
  66. Zinc-Based Early Detection of Prostate Cancer
    Christopher J Frederickson; Fiscal Year: 2010
    In Phase I we showed that our measurement of free zinc in expressed prostatic fluid is a promising clinical indicator of prostate cancer...
    Jennifer Morris; Fiscal Year: 1999
    ..are characterized by a t(11;17) translocation which fuses the retinoic acid receptor-alpha (RARa) to a novel zinc finger gene, promyelocytic leukemia zinc finger gene (PLZF)...
    William Konigsberg; Fiscal Year: 1999
    The objectives are to elucidate the structural and functional roles of Zn(II) in 1) zinc metalloenzymes, 2) the eukaryotic transcription factors originally termed zinc fingers, and 3) several proteins involved in nucleic acid replication ..
  69. Zinc inhibition of endotoxemia in alcoholic liver injury
    Zhanxiang Zhou; Fiscal Year: 2010
    b>Zinc inhibition of endotoxemia in alcoholic liver injury Abstract Alcoholic liver disease (ALD) is an important health problem, but an FDA-approved effective therapy is not available...
  70. Evaluation of zinc homeostasis mechanisms in Streptococcus pneumoniae
    FAITH ELLEN JACOBSEN; Fiscal Year: 2010
    ..In addition, S. pneumoniae experiences a wide variety of metal concentrations in its host organism. Zinc is an essential metal for S. pneumonaie growth and potentially for virulence...
    J Bentley; Fiscal Year: 1990
    ..this research is to determine the distribution, metabolism and physiological roles of the essential trace element zinc in the crystalline lens, especially with respect to the maintenance of its transparency and the prevention of ..
  72. New Strategies and Screening Methods for Metalloproteinase Inhibition
    Seth M Cohen; Fiscal Year: 2010
    The major objectives of this proposal are: a) to prepare a variety of bidentate sulfonamide inhibitors of zinc(II) metalloproteins, and b) develop a cell-based screening method for examining the effect of these inhibitors on several ..
  73. Development of ZnTe Powder Phosphor for Protein Crystallographic X-ray Detectors
    CHRISTOPHER SUMMERS; Fiscal Year: 2009
    ..provided by applicant): We propose to continue development of a new, high-performance X-ray phosphor, based on zinc telluride (ZnTe), doped with oxygen...
    John White; Fiscal Year: 2000
    The hippocampal formation, important for the process of laying down new memories, contains large amounts of zinc, located in synaptic vesicles and released with high-frequency stimulation...
  75. Genomic analysis of pediatric SIRS and septic shock
    Hector Wong; Fiscal Year: 2009
    ..The competitive revision seeks to develop a point-of-care platform for measuring serum zinc concentrations in children with septic shock, the "zinc chip...
  76. Structural Investigation of Allosteric Regulation in Bacterial Carbonic Anhydrase
    JEFF CRONK; Fiscal Year: 2007
    ..and physiological importance, the interconversion of carbon dioxide and bicarbonate ion CO2 + H2O - All CAs are zinc-dependent enzymes and a well-established mechanistic paradigm requires the coordination of substrate to the ..
  77. Human Zinc Transporter Zip 13 and Cellular Zinc Homeostasis
    Joel Walker; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Zinc is an essential nutrient needed for many cellular processes, however, excess zinc leads to cell death...
  78. Towards tuberculosis control: pyrazinamide susceptibility and resistant mechanism
    Patricia Sheen; Fiscal Year: 2007
    ..site, will revert its PZase activity, turning to a PZA-sensitive phenotype, under high concentrations of zinc ions, the probable cofactor...
  79. Modulation of DNA methylation status by dietary zinc: role in cancer prevention
    LOUISE FONG; Fiscal Year: 2009
    ..In particular, zinc deficiency (ZD) reduces the utilization of methyl groups from S-adenosylmethionine (SAM) in rat liver, resulting in ..
    Sinisa Dovat; Fiscal Year: 2003
    ..Ikaros encodes a zinc finger protein whose expression is restricted to hematopoietic cells...
    Pamela Fraker; Fiscal Year: 2007
    The zinc deficient mouse (ZD) is a valuable model for elucidating the molecular and biochemical changes made by the immune system to provide a core of host defense in the face of suboptimal nutriture...
    Michael Summers; Fiscal Year: 1993
    ..and their proteolytic nucleic acid binding protein (NABP) products contain, without exception, conserved "zinc finger" amino acid sequences: -Cys-X2-Cys-X3-Gly- His-X4-Cys- (X = variable amino acid)...