tungsten

Summary

Summary: Tungsten. A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. It is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.

Top Publications

  1. ncbi Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Free Radic Biol Med 41:1353-60. 2006
  2. ncbi In vivo corrosion, tumor outcome, and microarray gene expression for two types of muscle-implanted tungsten alloys
    B E Schuster
    U S Army Research Laboratory, Weapons and Materials Research Directorate, B434 Mulberry Road, Aberdeen Proving Ground, MD 21005 5609, USA
    Toxicol Appl Pharmacol 265:128-38. 2012
  3. ncbi Metals and health: a clinical toxicological perspective on tungsten and review of the literature
    Gijsbert B van der Voet
    Division of Biophysical Toxicology, Department of Environmental and Infectious Disease Sciences, Armed Forces Institute of Pathology, 6825 16th NW, Washington, DC 20306 6000, USA
    Mil Med 172:1002-5. 2007
  4. pmc Multi-walled carbon nanotube-doped tungsten oxide thin films for hydrogen gas sensing
    Chatchawal Wongchoosuk
    Department of Physics and Center of Nanoscience and Nanotechnology, Faculty of Science, Mahidol University, Ratchathewee, Bangkok 10400, Thailand
    Sensors (Basel) 10:7705-15. 2010
  5. ncbi A role for tungsten in the biology of Campylobacter jejuni: tungstate stimulates formate dehydrogenase activity and is transported via an ultra-high affinity ABC system distinct from the molybdate transporter
    Jonathan P Smart
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Mol Microbiol 74:742-57. 2009
  6. ncbi Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten-nickel-cobalt alloys in vitro
    R M Harris
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Toxicol Appl Pharmacol 250:19-28. 2011
  7. ncbi Pulmonary toxicity after exposure to military-relevant heavy metal tungsten alloy particles
    Erik Q Roedel
    Department of General Surgery, Tripler Army Medical Center, Honolulu, HI 96859, USA
    Toxicol Appl Pharmacol 259:74-86. 2012
  8. ncbi Use of the Oak Ridge National Laboratory tungsten-188/rhenium-188 generator for preparation of the rhenium-188 HDD/lipiodol complex for trans-arterial liver cancer therapy
    Jae Min Jeong
    Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea
    Semin Nucl Med 38:S19-29. 2008
  9. ncbi Diversity and community structure of culturable arsenic-resistant bacteria across a soil arsenic gradient at an abandoned tungsten-tin mining area
    Angel Valverde
    Instituto de Recursos Naturales y Agrobiología de Salamanca CSIC, Apartado 257, 37071 Salamanca, Spain
    Chemosphere 85:129-34. 2011
  10. ncbi Comprehensive characterization and failure modes of tungsten microwire arrays in chronic neural implants
    Abhishek Prasad
    Department of Biomedical Engineering, University of Miami, FL, USA
    J Neural Eng 9:056015. 2012

Detail Information

Publications302 found, 100 shown here

  1. ncbi Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Free Radic Biol Med 41:1353-60. 2006
    ..ApoE(-/-) mice were fed a Western-type (WD) or control diet. In subgroups, tungsten (700 mg/L) was administered to inhibit XO...
  2. ncbi In vivo corrosion, tumor outcome, and microarray gene expression for two types of muscle-implanted tungsten alloys
    B E Schuster
    U S Army Research Laboratory, Weapons and Materials Research Directorate, B434 Mulberry Road, Aberdeen Proving Ground, MD 21005 5609, USA
    Toxicol Appl Pharmacol 265:128-38. 2012
    b>Tungsten alloys are composed of tungsten microparticles embedded in a solid matrix of transition metals such as nickel, cobalt, or iron...
  3. ncbi Metals and health: a clinical toxicological perspective on tungsten and review of the literature
    Gijsbert B van der Voet
    Division of Biophysical Toxicology, Department of Environmental and Infectious Disease Sciences, Armed Forces Institute of Pathology, 6825 16th NW, Washington, DC 20306 6000, USA
    Mil Med 172:1002-5. 2007
    b>Tungsten and tungsten compounds are considered toxicologically relatively safe...
  4. pmc Multi-walled carbon nanotube-doped tungsten oxide thin films for hydrogen gas sensing
    Chatchawal Wongchoosuk
    Department of Physics and Center of Nanoscience and Nanotechnology, Faculty of Science, Mahidol University, Ratchathewee, Bangkok 10400, Thailand
    Sensors (Basel) 10:7705-15. 2010
    ..we have fabricated hydrogen gas sensors based on undoped and 1 wt% multi-walled carbon nanotube (MWCNT)-doped tungsten oxide (WO(3)) thin films by means of the powder mixing and electron beam (E-beam) evaporation technique...
  5. ncbi A role for tungsten in the biology of Campylobacter jejuni: tungstate stimulates formate dehydrogenase activity and is transported via an ultra-high affinity ABC system distinct from the molybdate transporter
    Jonathan P Smart
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Mol Microbiol 74:742-57. 2009
    ..of single and double mutants showed that this large difference in affinity is reflected in a lower cellular tungsten content in a cj1540 (tupA) mutant compared with a cj0303c (modA) mutant...
  6. ncbi Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten-nickel-cobalt alloys in vitro
    R M Harris
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Toxicol Appl Pharmacol 250:19-28. 2011
    b>Tungsten alloys (WA) have been introduced in an attempt to find safer alternatives to depleted uranium and lead munitions...
  7. ncbi Pulmonary toxicity after exposure to military-relevant heavy metal tungsten alloy particles
    Erik Q Roedel
    Department of General Surgery, Tripler Army Medical Center, Honolulu, HI 96859, USA
    Toxicol Appl Pharmacol 259:74-86. 2012
    ..War and the war in the Balkans has prompted the investigation and use of other materials including heavy metal tungsten alloys (HMTAs) as nontoxic alternatives...
  8. ncbi Use of the Oak Ridge National Laboratory tungsten-188/rhenium-188 generator for preparation of the rhenium-188 HDD/lipiodol complex for trans-arterial liver cancer therapy
    Jae Min Jeong
    Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea
    Semin Nucl Med 38:S19-29. 2008
    This work describes the installation, use, and quality control (QC) of the alumina-based tungsten-188 ((188)W)/rhenium-188 ((188)Re) generators provided by the Oak Ridge National Laboratory (ORNL)...
  9. ncbi Diversity and community structure of culturable arsenic-resistant bacteria across a soil arsenic gradient at an abandoned tungsten-tin mining area
    Angel Valverde
    Instituto de Recursos Naturales y Agrobiología de Salamanca CSIC, Apartado 257, 37071 Salamanca, Spain
    Chemosphere 85:129-34. 2011
    ..It was also shown that, under aerobic conditions, strains with relatively enhanced tolerance to As(III) predominated over the most As(V)-tolerant ones...
  10. ncbi Comprehensive characterization and failure modes of tungsten microwire arrays in chronic neural implants
    Abhishek Prasad
    Department of Biomedical Engineering, University of Miami, FL, USA
    J Neural Eng 9:056015. 2012
    For nearly 55 years, tungsten microwires have been widely used in neurophysiological experiments in animal models to chronically record neuronal activity...
  11. ncbi Molybdenum and tungsten in Campylobacter jejuni: their physiological role and identification of separate transporters regulated by a single ModE-like protein
    Michael E Taveirne
    Department of Microbiology, North Carolina State University, Raleigh, NC 27695, USA
    Mol Microbiol 74:758-71. 2009
    ..least four enzymes predicted to contain a metal binding pterin (MPT), with the metal being either molybdenum or tungsten. Also predicted are two separate transport systems, one for molybdenum encoded by modABC and a second for ..
  12. ncbi Dissolution of tungsten coils does not produce systemic toxicity, but leads to elevated levels of tungsten in the serum and recanalization of the previously occluded vessel
    Matthias Peuster
    Department of Pediatric Cardiology and Pediatric Intensive Care, Georg August University, Robert Koch Str 40, D 37075 Goettingen, Germany
    Cardiol Young 12:229-35. 2002
    To evaluate the failure of mechanically detachable spirals produced from tungsten (MDS, Balt, Montmorency, France) and the toxicity of elevated levels of tungsten in the serum subsequent to their implantation.
  13. ncbi Tungsten toxicity
    Mark L Witten
    Odyssey Research Institute, 7032 East Rosewood Street, Tucson, AZ 85710 1236, United States
    Chem Biol Interact 196:87-8. 2012
    There is emerging evidence that tungsten has toxic health effects. We summarize the recent tungsten toxicity research in this short review...
  14. ncbi Tungsten effects on phosphate-dependent biochemical pathways are species and liver cell line dependent
    David R Johnson
    Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, Mississippi 39180, USA
    Toxicol Sci 116:523-32. 2010
    b>Tungsten, in the form of tungstate, polymerizes with phosphate, and as extensive polymerization occurs, cellular phosphorylation and dephosphorylation reactions may be disrupted, resulting in negative effects on cellular functions...
  15. ncbi Dissolution of copper, tin, and iron from sintered tungsten-bronze spheres in a simulated avian gizzard, and an assessment of their potential toxicity to birds
    Vernon G Thomas
    Department of Integrative Biology, College of Biological Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Sci Total Environ 394:283-9. 2008
    The rates of dissolution of copper, tin, and iron from sintered tungsten-bronze spheres (51.1%W, 44.4%Cu, 3.9%Sn, 0.6%Fe, by mass) were measured in an in vitro simulated avian gizzard at pH 2.0, and 42C...
  16. ncbi Bio-availability of tungsten in the vicinity of an abandoned mine in the English Lake District and some potential health implications
    Bob Wilson
    Interdisciplinary Biomedical Research Centre, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK
    Sci Total Environ 370:401-8. 2006
    This research addresses the occurrence, detection and possible fate of tungsten in the vicinity of an abandoned mine in the English Lake District...
  17. ncbi Improvement of gaseous pollutant photocatalysis with WO3/TiO2 heterojunctional-electrical layered system
    Yuan Liu
    State Key Laboratory of Material Processing and Die and Mould Technology, Nanomaterials and Smart Sensors Laboratory, Department of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China
    J Hazard Mater 196:52-8. 2011
    ..2V. Furthermore, the results also showed that the remarkable improvement could not be obtained when either the WO(3) layer or the low external bias was absent...
  18. ncbi Nanoporous TiO2 and WO3 films by anodization of titanium and tungsten substrates: influence of process variables on morphology and photoelectrochemical response
    N R de Tacconi
    Center for Renewable Energy Science and Technology, The University of Texas at Arlington, Arlington, Texas 76019 0065, USA
    J Phys Chem B 110:25347-55. 2006
    ..The best photoactive films were obtained from poly(ethylene glycol) (PEG 400) containing NH4F for TiO2 and from aqueous NaF for WO3...
  19. ncbi Tungsten effects on survival, growth, and reproduction in the earthworm, Eisenia fetida
    Laura S Inouye
    U S Army Engineer Research and Development Center, Vicksburg, Mississippi 39180, USA
    Environ Toxicol Chem 25:763-8. 2006
    To provide basic toxicity data for formulating risk characterization benchmarks, the effects of tungsten on survival, growth, and reproduction were investigated in the earthworm Eisenia fetida...
  20. ncbi Illuminating tungsten's life cycle in the United States: 1975-2000
    E M Harper
    Center for Industrial Ecology, School of Forestry and Environmental Studies, 205 Prospect Street, Yale University, New Haven, Connecticut 06511, USA
    Environ Sci Technol 42:3835-42. 2008
    b>Tungsten's unique properties, such as its high density and melting point, are manifest in a variety of technological applications, and attention has recently centered upon the health and environmental effects of tungsten...
  21. ncbi Solid-state synthesis of molybdenum and tungsten porphyrins and aerial oxidation of coordinated benzenethiolate to benzenesulfonate
    Goutam Nandi
    Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India
    Inorg Chem 51:6412-20. 2012
    A new route is developed for the synthesis of molybdenum and tungsten porphyrins using [M(NO)(2)py(2)Cl(2)] (M = Mo, W) as the metal source and TPP (dianion of 5,10,15,20-meso-tetraphenylporphyrin) in the benzoic acid melt...
  22. ncbi SpekCalc: a program to calculate photon spectra from tungsten anode x-ray tubes
    G Poludniowski
    Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK
    Phys Med Biol 54:N433-8. 2009
    A software program, SpekCalc, is presented for the calculation of x-ray spectra from tungsten anode x-ray tubes...
  23. ncbi Direct imaging of the structure, relaxation, and sterically constrained motion of encapsulated tungsten polyoxometalate lindqvist ions within carbon nanotubes
    Jeremy Sloan
    Queen Mary, University of London, Department of Engineering and Materials, Mile End Road, London, UK
    ACS Nano 2:966-76. 2008
    The imaging properties and observation of the sterically regulated translational motion of discrete tungsten polyoxometalate Linqvist ions (i.e., [W(6)O(19)](2-)) within carbon nanotubes of specific internal diameter are reported...
  24. ncbi Characterization of a tungsten-substituted nitrogenase isolated from Rhodobacter capsulatus
    Stefan Siemann
    Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
    Biochemistry 42:3846-57. 2003
    ..On the basis of such conditions, a tungsten-substituted nitrogenase was isolated from R...
  25. ncbi Tungsten toxicity, bioaccumulation, and compartmentalization into organisms representing two trophic levels
    Alan J Kennedy
    US Army Engineer Research and Development Center, Vicksburg, Mississippi 39180, United States
    Environ Sci Technol 46:9646-52. 2012
    Metallic tungsten has civil and military applications and was considered a green alternative to lead. Recent reports of contamination in drinking water and soil have raised scrutiny and suspended some applications...
  26. ncbi Porous tungsten oxide nanoflakes for highly alcohol sensitive performance
    J Xiao
    State Key Laboratory of Optoelectronic Materials and Technologies, Institute of Optoelectronic and Functional Composite Materials, Nanotechnology Research Center, School of Physics and Engineering, Sun Yat Sen University, Guangzhou 510275, Guangdong, PR China
    Nanoscale 4:7078-83. 2012
    Porous tungsten oxide (WO(3)) nanoflakes have been synthesized by a simple and green approach in an ambient environment...
  27. ncbi Effects of tungsten on environmental systems
    Nikolay Strigul
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08540, USA
    Chemosphere 61:248-58. 2005
    b>Tungsten is a metal with many industrial and military applications, including manufacturing of commercial and military ammunition. Despite its widespread use, the potential environmental effects of tungsten are essentially unknown...
  28. ncbi A minimally invasive method for induction of myocardial infarction in an animal model using tungsten spirals
    Daniel Peukert
    Department of Radiology, Institut fur Radiologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, Germany
    Int J Cardiovasc Imaging 25:529-35. 2009
    ..catheter was advanced into the left circumflex artery (LCX) under electrocardiographic monitoring and small tungsten spirals were deployed in the vessel. LCX occlusion was verified by coronary angiography...
  29. pmc Unraveling metal-insulator transition mechanism of VO₂ triggered by tungsten doping
    Xiaogang Tan
    Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230026, China
    Sci Rep 2:466. 2012
    ....
  30. ncbi The tungsten-containing formate dehydrogenase from Methylobacterium extorquens AM1: purification and properties
    Markus Laukel
    Max Planck Institut fur terrestrische Mikrobiologie, Marburg, Germany
    Eur J Biochem 270:325-33. 2003
    ..6 mol noncovalently bound FMN, and approximately 1.8 mol tungsten. The genes encoding the two subunits of FDH1 were identified on the M...
  31. ncbi Bioavailability of tungsten and associated metals in calcareous soils in the vicinity of an ancient metalliferous mine in the Corbières area, southwestern France
    Bob Wilson
    Environmental Toxicology Health and Geochemistry Laboratory, Interdisciplinary Biomedical Research Centre School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom
    J Toxicol Environ Health A 72:807-16. 2009
    The mobility and bioavailability of tungsten and associated metals are examined in calcareous soils and subsequent bioaccumulation by four species of plants is determined...
  32. ncbi The fatal effect of tungsten on Pisum sativum L. root cells: indications for endoplasmic reticulum stress-induced programmed cell death
    Ioannis Dimosthenis S Adamakis
    Department of Botany, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Macedonia, Greece
    Planta 234:21-34. 2011
    ..b>Tungsten (W) is increasingly considered toxic for plants since it irreversibly affects their growth...
  33. ncbi Potential late health effects of depleted uranium and tungsten used in armor-piercing munitions: comparison of neoplastic transformation and genotoxicity with the known carcinogen nickel
    Alexandra C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Mil Med 167:120-2. 2002
    ..For comparison, we also examined tungsten alloys used in military projectiles and the known carcinogen nickel...
  34. pmc Pyranopterin conformation defines the function of molybdenum and tungsten enzymes
    Richard A Rothery
    Department of Biochemistry, University of Alberta, Edmonton, AB, Canada T6G 2H7
    Proc Natl Acad Sci U S A 109:14773-8. 2012
    We have analyzed the conformations of 319 pyranopterins in 102 protein structures of mononuclear molybdenum and tungsten enzymes...
  35. ncbi Tungsten-containing enzymes
    N P L'vov
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 117071 Russia
    Biochemistry (Mosc) 67:196-200. 2002
    The biological importance of tungsten has been fully proved in the last decade due to isolation of a number of tungsten-containing enzymes (W-enzymes) from hyperthermophilic archaea...
  36. ncbi Arsenic contamination and potential health risk implications at an abandoned tungsten mine, southern China
    Chuan ping Liu
    Guangdong Public Laboratory of Environmental Science and Technology, Guangdong Institute of Eco Environmental and Soil Sciences, Guangzhou 510650, China
    Environ Pollut 158:820-6. 2010
    ..field samples, including soil, water, rice, vegetable, fish, human hair and urine, were collected at an abandoned tungsten mine in Shantou City, southern China...
  37. ncbi Synthesis of polyethylene glycol (PEG) assisted tungsten oxide (WO3) nanoparticles for L-dopa bio-sensing applications
    V Hariharan
    Centre for Nanoscience and Technology, Department of Physics, Periyar University, Salem 636 011, Tamilnadu, India
    Talanta 85:2166-74. 2011
    Nanocrystalline tungsten oxides (WO(3-δ)) are currently receiving a lot of attention because of their interesting electrical, magnetic, optical and mechanical properties...
  38. ncbi Release of copper from sintered tungsten-bronze shot under different pH conditions and its potential toxicity to aquatic organisms
    Vernon G Thomas
    Department of Integrative Biology, College of Biological Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Sci Total Environ 374:71-9. 2007
    Sintered tungsten-bronze is a new substitute for lead shot, and is about to be deposited in and around the wetlands of North America. This material contains copper in the alloyed form of bronze...
  39. ncbi Urinary and serum metal levels as indicators of embedded tungsten alloy fragments
    John F Kalinich
    Armed Forces Radiobiology Research Institute, Uniformed Services University, Bethesda, MD 20889 5603, USA
    Mil Med 173:754-8. 2008
    ..In this report, we show that laboratory rats implanted with weapons-grade tungsten alloy (tungsten, nickel, and cobalt) pellets demonstrate significant increases in both urinary and serum levels ..
  40. ncbi Efficient heterogeneous and environmentally friendly degradation of nerve agents on a tungsten-based POM
    Dana M Mizrahi
    Department of Organic Chemistry, Israel Institute for Biological Research, P O Box 19, Ness Ziona 74100, Israel
    J Hazard Mater 179:495-9. 2010
    ..Mustard gas (HD), whose degradation is highly dependent on oxidation, was not decontaminated by this POM. Solid state MAS NMR ((31)P and (13)C) was utilized both for POM characterization and for decontamination studies monitoring...
  41. ncbi Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line
    Nina N Sun
    Southwest Environmental Science Center and Department of Pediatrics, University of Arizona College of Medicine, Tucson, USA
    Toxicol Ind Health 19:157-63. 2003
    ..Twenty-eight metals of both ores were quantified and their presence may be associated with the cell growth rate and dose-dependent activation of transcriptomes in immature T-cells...
  42. pmc Biomimetic chemistry of iron, nickel, molybdenum, and tungsten in sulfur-ligated protein sites
    Stanislav Groysman
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Biochemistry 48:2310-20. 2009
    ..This account describes the current status of the synthetic analogue approach as applied to the mononuclear sites in certain molybdoenzymes and the polynuclear sites in hydrogenases, nitrogenase, and carbon monoxide dehydrogenases...
  43. ncbi Novel bacterial molybdenum and tungsten enzymes: three-dimensional structure, spectroscopy, and reaction mechanism
    Matthias Boll
    Institut fur Biologie II, Universitat Freiburg, Schänzlestr 1, D 79104 Freiburg, Germany
    Biol Chem 386:999-1006. 2005
    The molybdenum enzymes 4-hydroxybenzoyl-CoA reductase and pyrogallol-phloroglucinol transhydroxylase and the tungsten enzyme acetylene hydratase catalyze reductive dehydroxylation reactions, i.e...
  44. ncbi A review of tungsten: from environmental obscurity to scrutiny
    A Koutsospyros
    Department of Mechanical, Civil, and Environmental Engineering, University of New Haven, West Haven, CT 06516, USA
    J Hazard Mater 136:1-19. 2006
    Since its discovery, tungsten, a transition element of Group VIb of the Periodic Table of Elements, and its compounds have been considered environmentally benign...
  45. pmc Corrosion of tungsten microelectrodes used in neural recording applications
    Erin Patrick
    Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA
    J Neurosci Methods 198:158-71. 2011
    ..The corrosion of tungsten microwire electrodes used for intracortical recording applications was analyzed in a controlled bench-top study ..
  46. ncbi The tungsten formylmethanofuran dehydrogenase from Methanobacterium thermoautotrophicum contains sequence motifs characteristic for enzymes containing molybdopterin dinucleotide
    A Hochheimer
    Max Planck Institut fur terrestrische Mikrobiologie, Philipps Universitat, Marburg, Germany
    Eur J Biochem 234:910-20. 1995
    Formylmethanofuran dehydrogenases are molybdenum or tungsten iron-sulfur proteins containing a pterin dinucleotide cofactor...
  47. ncbi The active sites of molybdenum- and tungsten-containing enzymes
    J McMaster
    Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA
    Curr Opin Chem Biol 2:201-7. 1998
    Protein X-ray crystallography has revealed the structures of the active sites of several molybdenum- and tungsten-containing enzymes that catalyze formal hydroxylation and oxygen atom transfer reactions...
  48. ncbi Molybdenum, rhodium, and tungsten anode spectral models using interpolating polynomials with application to mammography
    J M Boone
    Department of Radiology, University of California, Davis, UC Davis Medical Center, Sacramento 95817, USA
    Med Phys 24:1863-74. 1997
    ..Using x-ray spectra measured for molybdenum, rhodium, and tungsten anode x-ray tubes at 13 different kV's (18, 20, 22, .....
  49. ncbi Multiple environmental monitoring techniques for assessing spatial patterns of airborne tungsten
    Paul R Sheppard
    Laboratory of Tree Ring Research and Department of Pediatrics, University of Arizona, Tucson, Arizona 85721, USA
    Environ Sci Technol 41:406-10. 2007
    ..of total suspended particulates, lichens/mosses, and surface dust for assessing spatial patterns of airborne tungsten and other metals...
  50. pmc Mechanism of tungsten-dependent acetylene hydratase from quantum chemical calculations
    Rong Zhen Liao
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE 10691 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:22523-7. 2010
    Acetylene hydratase is a tungsten-dependent enzyme that catalyzes the nonredox hydration of acetylene to acetaldehyde...
  51. pmc Conical tungsten tips as substrates for the preparation of ultramicroelectrodes
    Andre Hermans
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    Langmuir 22:10348-53. 2006
    Here we describe a simple method to prepare voltammetric microelectrodes using tungsten wires as a substrate...
  52. ncbi In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components
    Ranjana Verma
    Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Toxicol Appl Pharmacol 253:178-87. 2011
    b>Tungsten-alloy has carcinogenic potential as demonstrated by cancer development in rats with intramuscular implanted tungsten-alloy pellets...
  53. ncbi Gene sequence and the 1.8 A crystal structure of the tungsten-containing formate dehydrogenase from Desulfovibrio gigas
    Hans Raaijmakers
    REQUIMTE CQFB, Departamento de Quimica, FCT, Universidade Nova de Lisboa, 2829 516 Caparica, Portugal
    Structure 10:1261-72. 2002
    Desulfovibrio gigas formate dehydrogenase is the first representative of a tungsten-containing enzyme from a mesophile that has been structurally characterized. It is a heterodimer of 110 and 24 kDa subunits...
  54. pmc Precipitation of a monoclonal antibody by soluble tungsten
    Jared S Bee
    Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80309, USA
    J Pharm Sci 98:3290-301. 2009
    b>Tungsten microparticles may be introduced into some pre-filled syringes during the creation of the needle hole. In turn, these microcontaminants may interact with protein therapeutics to produce visible particles...
  55. ncbi Spatial patterns of tungsten and cobalt in surface dust of Fallon, Nevada
    Paul R Sheppard
    Laboratory of Tree Ring Research, University of Arizona, Tucson, AZ 85721, USA
    Environ Geochem Health 29:405-12. 2007
    Spatial patterns of tungsten and cobalt are described for surface dust of Fallon, Nevada, where a cluster of childhood leukemia has been ongoing since 1997...
  56. ncbi Tungsten-induced protein aggregation: solution behavior
    Yijia Jiang
    Formulation and Analytical Resources, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    J Pharm Sci 98:4695-710. 2009
    b>Tungsten has been associated with protein aggregation in prefilled syringes (PFSs). This study probed the relationship between PFSs, tungsten, visible particles, and protein aggregates...
  57. ncbi Using lichen chemistry to assess airborne tungsten and cobalt in Fallon, Nevada
    Paul R Sheppard
    Laboratory of Tree Ring Research, University of Arizona, Tucson, AZ 85721, USA
    Environ Monit Assess 130:511-8. 2007
    This paper describes the use of lichen chemistry to assess airborne tungsten and cobalt in Fallon, Nevada, where a cluster of childhood leukemia has been on going since 1997...
  58. ncbi Availability of rhenium-188 from the alumina-based tungsten-188/rhenium-188 generator for preparation of rhenium-188-labeled radiopharmaceuticals for cancer treatment
    F F Knapp
    Nuclear Medicine Program, Oak Ridge National Laboratory ORNL, TN, USA
    Anticancer Res 17:1783-95. 1997
    ..9 hours) is an attractive therapeutic radioisotope which is produced from decay of the reactor-produced tungsten-188 parent (T1/2 69 days) and thus conveniently obtained on demand by elution from the alumina-based tungsten-188 ..
  59. ncbi Risk of silicosis in cohorts of Chinese tin and tungsten miners, and pottery workers (I): an epidemiological study
    W Chen
    Department of Labor Health and Occupational Diseases, Tongji Medical College, School of Public Health, Hang Kong Lu, Wuhan, Hubei, People s Republic of China
    Am J Ind Med 48:1-9. 2005
    ..aim of this study is to compare the risk of silicosis among cohorts of silica dust-exposed Chinese tin miners, tungsten miners, and pottery workers and to assess whether gravimetric measurements of respirable silica dust sufficiently ..
  60. ncbi Comparison of quartz-tungsten-halogen, light-emitting diode, and plasma arc curing lights
    Richard B T Price
    Department of Dental Clinical Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
    J Adhes Dent 5:193-207. 2003
    ..The hypothesis was that there would be no difference in the hardness of the composites when irradiated by any of the lights...
  61. ncbi Tungsten, the surprisingly positively acting heavy metal element for prokaryotes
    Jan R Andreesen
    Institute of Biology Microbiology, Martin Luther University Halle Wittenberg, Halle, Germany
    Ann N Y Acad Sci 1125:215-29. 2008
    The history and changing function of tungsten as the heaviest element in biological systems is given...
  62. ncbi A quantitative analysis of aerosols inside an armored vehicle perforated by a kinetic energy penetrator containing tungsten, nickel, and cobalt
    Kenneth Gold
    U S Army Research, Development and Engineering Command, Armament Research, Development and Engineering Center, Armaments Engineering and Technology Center, Environmental Technology Division, Picatinny Arsenal, NJ 07806 5000, USA
    Mil Med 172:393-8. 2007
    ..Quantitative data are reported for aerosols produced by kinetic energy penetrators containing tungsten, nickel, and cobalt...
  63. ncbi Molecular and biochemical characterization of two tungsten- and selenium-containing formate dehydrogenases from Eubacterium acidaminophilum that are associated with components of an iron-only hydrogenase
    Andrea Graentzdoerffer
    Institut für MikrobiologieMartin Luther Universität Halle Wittenberg, Kurt Mothes Strasse 3, 06099, Halle, Germany
    Arch Microbiol 179:116-30. 2003
    ..The purified formate dehydrogenase fraction contained iron, tungsten, a pterin cofactor, and zinc, but no molybdenum. FDH-II had a two-fold higher K(m) for formate (0...
  64. pmc Characterization and cytotoxic assessment of ballistic aerosol particulates for tungsten alloy penetrators into steel target plates
    Brenda I Machado
    Department of Metallurgical and Materials Engineering, The University of Texas at El Paso, El Paso, TX 79968, USA
    Int J Environ Res Public Health 7:3313-31. 2010
    The nature and constituents of ballistic aerosol created by kinetic energy penetrator rods of tungsten heavy alloys (W-Fe-Ni and W-Fe-Co) perforating steel target plates was characterized by scanning and transmission electron microscopy...
  65. ncbi Effects of particulates, heavy metals and acid gas on the removals of NO and PAHs by V2O5-WO3 catalysts in waste incineration system
    Feng Yim Chang
    Department of Environmental Engineering, National Chung Hsing University, Taichung 402, Taiwan, ROC
    J Hazard Mater 170:239-46. 2009
    ..The results of ESCA analysis reveal that the presence of these pollutants on the surface of catalysts did not change the chemical state of V and W...
  66. ncbi Risk of silicosis in cohorts of Chinese tin and tungsten miners and pottery workers (II): Workplace-specific silica particle surface composition
    J Harrison
    Health Effects Laboratory Division, US National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Am J Ind Med 48:10-5. 2005
    ..In conjunction with an epidemiological investigation of silicosis disease risk in Chinese tin and tungsten mine and pottery workplaces, we analyzed respirable silica dusts using a multiple-voltage scanning electron ..
  67. pmc Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase
    Grazyna B Seiffert
    Fachbereich Biologie, Universitat Konstanz, 78457 Konstanz, Germany
    Proc Natl Acad Sci U S A 104:3073-7. 2007
    The tungsten-iron-sulfur enzyme acetylene hydratase stands out from its class because it catalyzes a nonredox reaction, the hydration of acetylene to acetaldehyde...
  68. ncbi Biological monitoring of tungsten (and cobalt) in workers of a hard metal alloy industry
    Giuseppe De Palma
    Department of Experimental and Applied Medicine, University of Brescia, Italy
    Int Arch Occup Environ Health 83:173-81. 2010
    To evaluate a combined biomonitoring approach based on both cobalt and tungsten determination in workers of the hard metal alloy sector.
  69. ncbi Effect of tungsten and molybdenum on growth of a syntrophic coculture of Syntrophobacter fumaroxidans and Methanospirillum hungatei
    Caroline M Plugge
    Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB, Wageningen, The Netherlands
    Arch Microbiol 191:55-61. 2009
    The effect of tungsten (W) and molybdenum (Mo) on the growth of Syntrophobacter fumaroxidans and Methanospirillum hungatei was studied in syntrophic cultures and the pure cultures of both the organisms...
  70. ncbi Nitrogen-doped tungsten oxide nanowires: low-temperature synthesis on Si, and electrical, optical, and field-emission properties
    Mu Tung Chang
    Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan 300, R O C
    Small 3:658-64. 2007
    Very dense and uniformly distributed nitrogen-doped tungsten oxide (WO(3)) nanowires were synthesized successfully on a 4-inch Si(100) wafer at low temperature...
  71. ncbi Catechol siderophores control tungsten uptake and toxicity in the nitrogen-fixing bacterium Azotobacter vinelandii
    Thomas Wichard
    Department of Geosciences, Princeton Environmental Institute, Guyot Hall, Princeton University, Princeton, New Jersey 08544, USA
    Environ Sci Technol 42:2408-13. 2008
    Molybdenum (Mo) and tungsten (W), which have similar chemistry, are present at roughly the same concentration in the earth's continental crust, and both are present in oxic systems as oxoanions, molybdate and tungstate...
  72. ncbi Estimating historical respirable crystalline silica exposures for Chinese pottery workers and iron/copper, tin, and tungsten miners
    Z Zhuang
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US Department of Health and Human Services, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Ann Occup Hyg 45:631-42. 2001
    ..0143 for iron/copper, 0.0355 for pottery factories, 0.0429 for tin mines, and 0.0861 for tungsten mines. Conversion factors for individual facilities within each industry were also calculated...
  73. ncbi Electroanalytical determination of tungsten and molybdenum in proteins
    P L Hagedoorn
    Kluyver Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Anal Biochem 297:71-8. 2001
    Recent crystal structure determinations accelerated the progress in the biochemistry of tungsten-containing enzymes...
  74. ncbi Vanadium and tungsten derivatives as antidiabetic agents: a review of their toxic effects
    Jose L Domingo
    Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, Reus, Spain
    Biol Trace Elem Res 88:97-112. 2002
    ..because of the tissue accumulation and potential toxicity derived from chronic administration of vanadium and tungsten compounds, the pharmacological use of vanadate or tungstate in the treatment of diabetes is not necessarily ..
  75. ncbi Molybdenum and tungsten enzymes: the xanthine oxidase family
    Carlos D Brondino
    Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Campus Universitario, 3000 Santa Fe, Argentina
    Curr Opin Chem Biol 10:109-14. 2006
    Mononuclear molybdenum and tungsten are found in the active site of a diverse group of enzymes that, in general, catalyze oxygen atom transfer reactions...
  76. ncbi Implantation mechanics of tungsten microneedles into peripheral nerve trunks
    Ken Yoshida
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, D3, 9220, Aalborg, Denmark
    Med Biol Eng Comput 45:413-20. 2007
    50 microm tungsten microneedles have been used as a means to introduce longitudinal intra-fascicular electrodes (LIFE) into small peripheral nerve fascicles...
  77. ncbi Acetylene hydratase of Pelobacter acetylenicus. Molecular and spectroscopic properties of the tungsten iron-sulfur enzyme
    R U Meckenstock
    Fakultat fur Biologie, Universitat Konstanz, Germany
    Eur J Biochem 264:176-82. 1999
    Acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate...
  78. ncbi Easy-to-prepare assembly array of Tungsten microelectrodes
    Hirokazu Takahashi
    Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    IEEE Trans Biomed Eng 52:952-6. 2005
    This paper provides a detailed process flow for fabricating an easy-to-prepare, inexpensive, dense array of tungsten microelectrodes...
  79. ncbi Tungsten coil devices in atomic spectrometry: absorption, fluorescence, and emission
    X Hou
    Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA
    Anal Sci 17:175-80. 2001
    In this work, tungsten coil (W-Coil) devices are used as atomizers for electrothermal atomization atomic absorption spectrometry (ETAAS), electrothermal atomization laser excited atomic fluorescence spectrometry (ETA-LEAFS), and ..
  80. ncbi Flexible polymer substrate and tungsten microelectrode array for an implantable neural recording system
    Erin Patrick
    Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:3158-61. 2008
    This paper describes the process flow and testing of a substrate for a fully implantable neural recording system. Tungsten microwires are hybrid-packaged on a micromachined flexible polymer substrate forming an intracortical ..
  81. pmc Sulfur K-edge XAS of WVO vs. MoVO bis(dithiolene) complexes: contributions of relativistic effects to electronic structure and reactivity of tungsten enzymes
    Adam L Tenderholt
    Department of Chemistry, Stanford University, USA
    J Inorg Biochem 101:1594-600. 2007
    Molybdenum- or tungsten-containing enzymes catalyze oxygen atom transfer reactions involved in carbon, sulfur, or nitrogen metabolism...
  82. ncbi Synthesis of structural analogues of the oxidized sites in the xanthine oxidoreductase enzyme family
    Jun Jieh Wang
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 129:7512-3. 2007
  83. ncbi Dioxotungsten 1,2-benzenedithiolate complex stabilized by NH...S hydrogen bonds
    Koji Baba
    Chemical Analysis Research Center, National Institute for Agro Environmental Sciences, Tsukuba, Ibaraki 305 8604, Japan
    Inorg Chem 45:8365-71. 2006
    Novel dioxo-tungsten(VI) bis(1,2-benzenedithiolate) complexes with neighboring amide groups, as models for tungsten enzymes, (NEt4)2[W(VI)O2{1,2-S(2)-3,6-(RCONH)2C6H2}2] (R = CH3, t-Bu), were designed and synthesized...
  84. pmc Temporal variability of tungsten and cobalt in Fallon, Nevada
    Paul R Sheppard
    Laboratory of Tree Ring Research, University of Arizona, Tucson, Arizona 85721, USA
    Environ Health Perspect 115:715-9. 2007
    ..Multiple environmental studies have shown airborne tungsten and cobalt to be elevated within Fallon, but the question remains: Have these metals changed through time in ..
  85. ncbi Redox chemistry of tungsten and iron-sulfur prosthetic groups in Pyrococcus furiosus formaldehyde ferredoxin oxidoreductase
    Emile Bol
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
    J Biol Inorg Chem 11:999-1006. 2006
    ..In dye-mediated equilibrium redox titrations, the tungsten in active P. furiosus FOR is a two-electron acceptor, W(VI/IV)...
  86. ncbi Characteristics of dusts encountered during the production of cemented tungsten carbides
    Aleksandr B Stefaniak
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Ind Health 45:793-803. 2007
    Inhalation of cobalt (Co) and tungsten carbide (WC) particles, but not Co or WC alone, may cause hard metal disease, risk of which does not appear to be uniform across cemented tungsten carbide (CTC) production processes...
  87. pmc Exhaled breath condensate as a suitable matrix to assess lung dose and effects in workers exposed to cobalt and tungsten
    Matteo Goldoni
    National Institute of Occupational Safety and Prevention, Research Centre at the University of Parma, Parma, Italy
    Environ Health Perspect 112:1293-8. 2004
    ..exhaled air, can be used as a suitable matrix to assess target tissue dose and effects of inhaled cobalt and tungsten, using EBC malondialdehyde (MDA) as a biomarker of pulmonary oxidative stress...
  88. ncbi Presence of airborne fibers in tungsten refining and manufacturing processes: preliminary characterization
    John L McKernan
    Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    J Occup Environ Hyg 5:463-74. 2008
    In tungsten refining and manufacturing processes, a series of tungsten oxides (WO(X)) are typically formed as intermediates in the production of tungsten powder...
  89. ncbi Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: beneficial action of melatonin and N-acetylcysteine
    A Kiersztan
    Department of Metabolic Regulation, Institute of Biochemistry, Warsaw University, Warszawa, Poland
    Mol Cell Biochem 261:9-21. 2004
    ..As serum glucose levels were also significantly diminished by vanadium+melatonin treatment of diabetic animals, the combination therapy of vanadium compounds and melatonin needs a careful evaluation...
  90. ncbi Analogue reaction systems of selenate reductase
    Jun Jieh Wang
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Inorg Chem 45:2979-88. 2006
    ..Carboxylate binding has been crystallographically demonstrated for one nitrate reductase, but not for the other two enzymes...
  91. pmc Presence of tungsten-containing fibers in tungsten refining and manufacturing processes
    John L McKernan
    Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    Ann Occup Hyg 53:215-24. 2009
    In tungsten refining and manufacturing processes, a series of tungsten oxides are typically formed as intermediates in the production of tungsten powder...
  92. ncbi Uncertainty of inductively coupled plasma mass spectrometry based measurements: an application to the analysis of urinary barium, cesium, antimony and tungsten
    A Alimonti
    Department of Environment and Primary Prevention, Italian National Institute of Health, Rome, Italy
    Rapid Commun Mass Spectrom 19:3131-8. 2005
    The wide use of barium (Ba), cesium (Cs), antimony (Sb) and tungsten (W) in many industrial and agricultural fields causes the increased release of these metals into the environment, laying the basis for health risk...
  93. ncbi Arsenic, As((III)), and tungsten in Nevada County's private water supplies
    Mark Walker
    Department of Natural Resources and Environmental Sciences, University of Nevada, Reno, NV 89557 0013, USA
    J Water Health 7:293-301. 2009
    ..In a rural county in Nevada, USA, we measured concentrations of arsenic and tungsten and the proportion of arsenic occurring in trivalent form (As((III))) in tap water samples from private domestic ..
  94. ncbi Enzymatic and physiological properties of the tungsten-substituted molybdenum TMAO reductase from Escherichia coli
    J Buc
    Laboratoire de Chimie Bacterienne, CNRS, Marseille, France
    Mol Microbiol 32:159-68. 1999
    ..We have successfully substituted the molybdenum with tungsten and obtained an active tungsto-TMAO reductase...
  95. ncbi Characterization of a novel tungsten-containing formaldehyde ferredoxin oxidoreductase from the hyperthermophilic archaeon, Thermococcus litoralis. A role for tungsten in peptide catabolism
    S Mukund
    Department of Biochemistry, University of Georgia, Athens 30602
    J Biol Chem 268:13592-600. 1993
    ..Its growth is stimulated by tungsten, and a tungsten-containing iron-sulfur protein that has formaldehyde ferredoxin oxidoreductase (FOR) activity has ..
  96. pmc Purification and molecular characterization of the tungsten-containing formaldehyde ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus: the third of a putative five-member tungstoenzyme family
    R Roy
    Department of Biochemistry and Molecular Biology and Center for Metalloenzyme Studies, University of Georgia, Athens, Georgia 30602, USA
    J Bacteriol 181:1171-80. 1999
    ..Its growth requires tungsten, and two different tungsten-containing enzymes, aldehyde ferredoxin oxidoreductase (AOR) and glyceraldehyde-3-..
  97. ncbi Comparative evaluation of the in vitro micronucleus test and the alkaline single cell gel electrophoresis assay for the detection of DNA damaging agents: genotoxic effects of cobalt powder, tungsten carbide and cobalt-tungsten carbide
    F van Goethem
    Laboratory of Antropogenetics, Faculty of Science, Free University Brussels VUB, Belgium
    Mutat Res 392:31-43. 1997
    ..We therefore compared the genotoxic potential of pure cobalt powder (Co) and a cobalt-containing alloy, cobalt-tungsten carbide (WC-Co), involved in specific lung disorders, in parallel with the alkaline single cell gel ..
  98. pmc Identification and characterization of the tungsten-containing class of benzoyl-coenzyme A reductases
    Johannes W Kung
    Institute of Biochemistry, University of Leipzig, 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 106:17687-92. 2009
    ..BamBC represents the prototype of a previously undescribed class of dearomatizing BCRs that differ completely from the ATP-dependent enzymes from facultative anaerobes...
  99. ncbi Substitution and oxidation reactions of bis(dithiolene)tungsten complexes of potential relevance to enzyme sites
    K M Sung
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Inorg Chem 40:4518-25. 2001
    Structurally characterized tungstoenzymes contain mononuclear active sites in which tungsten is coordinated by two pterin-dithiolene ligands and one or two additional ligands that have not been identified...
  100. ncbi Molybdenum and tungsten in biology
    Russ Hille
    Dept of Molecular and Cellular Biochemistry and The Protein Research Group, The Ohio State University, Columbus, OH 43210 1218, USA
    Trends Biochem Sci 27:360-7. 2002
    ..metal that is required by most living organisms, and the few species that do not require molybdenum use tungsten, which lies immediately below molybdenum in the periodic table...
  101. ncbi Photoelectron spectroscopy of the doubly-charged anions [MIVO(mnt)2]2- (M = Mo, W; mnt = S2C2(CN)2(2-): access to the ground and excited states of the [MVO(mnt)2]- anion
    Tom Waters
    School of Chemistry, University of Melbourne, Victoria, Australia, 3010
    J Am Chem Soc 126:5119-29. 2004
    ..models for the active sites of the dimethyl sulfoxide reductase family of molybdenum enzymes and of related tungsten enzymes...

Research Grants62

  1. Molybdenum Pterin-Dithiolene Complexes for Model Studies of the Catalytic Site of
    SHARON BURGMAYER; Fiscal Year: 2007
    ..Not only humans, but nearly every organism on this planet relies on one or more molybdenum or tungsten enzymes...
  2. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALS
    Jacob McDonald; Fiscal Year: 2011
    ..Dimethylethanolamine;2',2'''-Dithiobisbenzanilide, 2-Hydroxy-4-methoxybenzophenone, Chromium, Tungsten. The goal of this contract is to provide support of National Toxicology Program (NTP) hazard assessment ..
  3. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALS
    Jacob McDonald; Fiscal Year: 2009
    ..2-Hydroxy-4-methoxybenzophenone, Chromium, Tungsten. The goal of this contract is to provide support of National Toxicology Program (NTP) hazard assessment ..
  4. HXe Hyperpolarised Xenon Production Technology Optimization
    F WILLIAM HERSMAN; Fiscal Year: 2012
    ..To prevent partial (or total) losses of xenon snow being blown from the freeze-out, we will introduce a fine tungsten wire coil into the helixes to anchor the snow while thawing...
  5. STRUCTURAL MODELS FOR MOLYBDOENZYMES
    John H Enemark; Fiscal Year: 2011
    Molybdenum and tungsten are the only second and third row transition elements that have known biological functions...
  6. Biomimetic stimulation of the sacral DRG to control continence and micturition
    ANDRE ELLIOTT SNELLINGS; Fiscal Year: 2010
    ..Recording electrodes, initially single tungsten wires and subsequently multi-electrode arrays will be used to record single unit activity from sacral afferent ..
  7. Preclinical cardiac imaging package for clinical SPECT systems
    Stephen C Moore; Fiscal Year: 2013
    ..The proposed collimator tube will be fabricated from tungsten-polymer using rapid-prototyping and casting techniques~ the initial version of this tube will contain a large ..
  8. Design Studies and Optimization of Phase-Contrast Mammography
    Mark A Anastasio; Fiscal Year: 2013
    ..We will investigate the use of a tungsten anode with relatively high kVp values for low-dose phase- contrast mammography...
  9. Novel tungsten and bismuth nanoparticle contrast agents for MicroCT.
    Vishwas N Joshi; Fiscal Year: 2012
    ..We now propose to develop heavy metal nanoparticle contrast agents based on tungsten and bismuth that are lot cheaper than our gold-based contrast agents and more absorptive than iodine...
  10. Brain "Imaging" with Polytrodes: Precise 3D Neuron Localization and Classificatio
    Timothy Blanche; Fiscal Year: 2010
    ..Single tungsten electrodes have been the principal technology for in vivo electrophysiological studies for decades, yet they have ..
  11. WC-Co nanoparticles in initiating angiogenesis by reactive oxygen species
    Bing Hua Jiang; Fiscal Year: 2010
    ..Our preliminary results show that exposure of epithelial cells to tungsten carbide cobalt (WC-Co) nanoparticles produced high levels of reactive oxygen species (ROS)...
  12. PATHOPHYSIOLOGY OF ISCHEMIA-REPERFUSION LUNG INJURY
    AUBREY TAYLOR; Fiscal Year: 1992
    ..versus hypoxia-reoxygenation, determination of the effect of blocking xanthine oxidase (allopurinol, or a tungsten- enriched diet) and removing neutrophils from the perfusate...
  13. Electrodeposited Noble Metal Oxide Neural Electrodes
    Stuart Cogan; Fiscal Year: 2002
    ..processes suitable for coating a broad range of metal substrates such as platinum, gold, PtIr-alloys, titanium, tungsten, and stainless steel, relevant to most neural recording and stimulating electrodes...
  14. Complementary Injectable Tungsten Contrast for Dual Contrast Dual Energy CT
    Benjamin M Yeh; Fiscal Year: 2013
    ..We propose to synthesize and test a carefully designed tungsten contrast material with a distinctly different biodistribution and X-ray absorption than those of conventional ..
  15. Method for In-Vivo Assessment of Neuronal Dysfunction
    Miguel A L Nicolelis; Fiscal Year: 2010
    ..We implant arrays of isonel-coated tungsten microwires (35 or 5Q\an, up to 48 per mouse) in multiple brain areas of the same animal...
  16. Catalytic Stereoselective Olefin Metathesis Reactions
    Richard R Schrock; Fiscal Year: 2013
    ..Research in this program is focused on the design, synthesis and development of a range of molybdenum- and tungsten-based catalysts that can be used for one of the most powerful and efficient methods for olefin synthesis: ..
  17. High resolution functional MRI of columnar structures
    Ravi Menon; Fiscal Year: 2007
    ..Electrical activity will be measured using both local field potentials and unit activity using tungsten electrodes...
  18. A Freeze-Fracture & Etching System for Northwestern Univ
    Mark Johnson; Fiscal Year: 2002
    ..CFE Freeze- Fracture Replication System outfitted with low and 45 degree angle platinum/carbon and tantalum/tungsten shadowing sources, two 90 degree carbon backing evaporation guns, two microtome holders, two Heuser mount ..
  19. Novel Titanium Material for Orthopaedic Lumbar Implants
    STANLEY ABKOWITZ; Fiscal Year: 2004
    Dynamet Technology will extend the NSF Phase I development of an innovative titanium-tungsten material to solve a critical need in orthopaedic surgery - a replacement lumbar disc with imaging capability...
  20. One Dimensional Hand Held Gamma Ray Scanner
    FARHAD DAGHIGHIAN; Fiscal Year: 2009
    ..we envision is a one-dimensional array of solid-state photomultipliers (SSPM) coupled to a scintillator slab and tungsten septa, forming a one-dimension gamma ray scanner...
  21. JSM-7001 FTTLS Scanning Electron Microscope
    Jeffrey T Corwin; Fiscal Year: 2012
    ..2 nm at 30 kV and 2.0 nm at 1 kV on the requested SEM, compared to 3.5 nm at 35 kV achievable with the existing tungsten filament SEM...
  22. CHIRAL PHOSPHORUS LIGANDS AND ANTISENSE OLIGONUCLEOTIDES
    William Hersh; Fiscal Year: 1999
    ..will allow for the facile synthesis of C2-symmetric phosphorus compounds that may be excellent ligands for chiral tungsten nitrosyl Lewis acids that give asymmetric catalysis of the Diels-Alder reaction...
  23. IMPROVED MODEL COMPLEXES FOR MOLYBDOENZYME ACTIVE SITES
    SHARON BURGMAYER; Fiscal Year: 2000
    ..structural benchmarks to aid in interpretation of analogous results from the enzymes and d) provide examples of fundamental chemistry needed to make progress in understanding the active site chemistry of molybdenum and tungsten enzymes.
  24. MULTITASK ASSESSMENT OF MOTOR UNIT FATIGUE
    ANDREW FUGLEVAND; Fiscal Year: 1999
    ..and variability will be determined from long trains of motor unit action potentials recorded with intramuscular tungsten microelectrodes. A third aim is to determine how the pattern of neural activity influences motor unit fatigue...
  25. Method for In-Vivo Assessment of Neuronal Dysfunction
    Miguel Nicolelis; Fiscal Year: 2007
    ..We implant arrays of isonel-coated tungsten microwires (35 or 5Q\an, up to 48 per mouse) in multiple brain areas of the same animal...
  26. STRUCTURE AND FUNCTION OF ENZYMES--ROLE OF METALS
    K Rajagopalan; Fiscal Year: 2007
    Molybdopterin is the essential, invariant component of the cofactors of all mononuclear molybdenum and tungsten-containing enzymes. Most prokaryotic enzymes contain dinucleotide forms of molybdopterin complexed with GMP, AMP, CMP or IMP...
  27. International Conference on Biological Inorganic Chemistry
    Dimitri Coucouvanis; Fiscal Year: 2005
    ..Folding Structural Dynamics, Bioorganometallic, Electron Transfer, Theoretical Calculations, Molybdenum and Tungsten, Zinc, Vanadium, Nitrogenase, Metalloenzyme Radical Catalysts, Hemes, Environmental Bioinorganic, Biomaterials, ..
  28. ON-CHIP DNA PURIFICATION/PCR FOR CANCER DIAGNOSTICS
    James Landers; Fiscal Year: 2000
    ..Using a tungsten lamp as an infrared heat source, noncontact temperature cycling will be executed on focused areas of the chip ..
  29. Image Reconstruction with Solid Srate SPECR
    LAWRENCE ZENG; Fiscal Year: 2005
    ..The strip gamma camera consists of a CdZnTe detector and a tungsten slat collimator...
  30. Development of diamond film technology electrodes
    ALFRED BONDS; Fiscal Year: 2004
    ..We will design and fabricate both single electrodes with full diamond coating on a tungsten core and multiple electrode arrays with eight sensitive regions, each consisting of an array of 16 microtips...
  31. INFRARED FUNDUS VIDEOANGIOGRAPHY SYSTEM
    JOSEPH CANTER; Fiscal Year: 1991
    ..shown to significantly reduce the irradiance required to obtain ICG angiograms as compared to a normal filtered tungsten source, A series of test in animals will be used in Phase II to assess the utility of the prototype device by ..
  32. COLORANT FORMULATION OF POLYMERIC PROSTHETIC MATERIALS
    William Johnston; Fiscal Year: 1992
    ..tissue displays unique optical characteristics which make an exact appearance match impossible for all daylight, tungsten, and fluorescent lighting conditions using currently available stable pigments...
  33. Breast Cancer Imaging Using a Solid-State SPECT Camera
    G Zeng; Fiscal Year: 2005
    ..The gamma camera consists of a CdZnTe detector and a tungsten or lead slat collimator; therefore this solid-state detector does not use photomultiplier-tubes...
  34. ENDOR of Tungsten Enzymes
    REBECCA MCNAUGHTON; Fiscal Year: 2005
    In the last decade, tungsten-containing enzymes have been isolated from a number of microorganisms including hyperthermophilic archaea, mesophilic archaea, and bacteria...
  35. NEW CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING
    MARIUSZ KOZIK; Fiscal Year: 1991
    ..the application) It is proposed to introduce paramagnetic transition metal-substituted heteropoly complexes of tungsten and molybdenum as contrast agents for Magnetic Resonance Imaging...
  36. MULTI-ROD VARIABLE COLLIMATOR FOR RADIATION THERAPY
    GABE BLOSSER; Fiscal Year: 1991
    ..The shaping of the radiation field is by an array of movable but permanently mounted tungsten rods, the position of the rods being set automatically by easy-to- fabricate styrofoam patterns...
  37. NOVEL X-RAY MAMMOGRAPHY SYSTEM DEVELOPMENT
    LOUIS KOPPEL; Fiscal Year: 1991
    ..Since the new system will use robust high-voltage tungsten-target x-ray tubes, rather than the conventional molybdenum tubes, an increase in tube life and a reduction in ..
  38. CHEMISTRY OF NH NR PREPARED FROM TRANSITION METALS
    GREGORY HILLHOUSE; Fiscal Year: 1992
    ..5 oC) displacement (by using bromide ions) of the coordinated cis-diazene ligands from easily prepared cationic tungsten complexes, which in turn are prepared by an insertion reaction of aryldiazonium ions into a tungsten hydride bond...
  39. Improved Scatter Reduction Grids for Mammography
    MICHAEL APPLEBY; Fiscal Year: 2005
    ..I, MSI proved technical feasibility by designing and fabricating cellular anti-scatter grids made of a dense tungsten powder / polymer composite material...
  40. Low-Cost Collimators for Nuclear Medicine Imaging
    MICHAEL APPLEBY; Fiscal Year: 2003
    ..technology will be used to produce advanced high-resolution collimators made from an improved material (tungsten powder composite)...
  41. Novel multi-spectral illumination for microscopy
    DAVID ZAHNISER; Fiscal Year: 2005
    ..the large discrete LEDs known in everyday uses) on a single substrate in a group about the size of a standard tungsten halogen bulb filament...
  42. HIGH ENERGY PHOTOELECTRONIC -DIGITAL MAMMOGRAPHY
    MILTON STOLLER; Fiscal Year: 1991
    ..23 keV). In general, the R&D is concerned with imaging of calcifications and soft tissue tumors using a tungsten tube operating in the range of 50-150 kVp, and demonstrating that preliminary theoretical analysis predicting ..
  43. Bi-Plane Correlation Imaging: Detection of Lung Cancer
    Ehsan Samei; Fiscal Year: 2007
    ..The findings will be used to substantiate the capability of BCI for improving the early detection of lung nodules and to optimize its performance on actual clinical cases. ..
  44. Early Detection of Lung Cancer via Bi Plane Correlation
    Ehsan Samei; Fiscal Year: 2002
    ..The findings will be used to demonstrate the capability of the approach for improving the detection of lung nodules, and thus the prognosis of lung cancer. ..
  45. Controlled Catalytic Reduction of Dinitrogen at a Transition Metal Center
    Richard R Schrock; Fiscal Year: 2010
    ..abstract_text> ..
  46. Monochromatic Phase-Contrast Breast Cancer Radiography
    Edwin Donnelly; Fiscal Year: 2005
    ..Image quality of all images will be judged by an experienced mammographer. ..
  47. Phase Contrast Computed Tomography Scanner
    Edwin Donnelly; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  48. Resolution requirements for mammographic displays
    Ehsan Samei; Fiscal Year: 2004
    ..The results will be used to formulate recommendations to the breast imaging community concerning display resolution criteria for safe and optimized soft-copy display of digital mammograms. ..
  49. SYNTHESIS OF NATURAL PRODUCTS WITH OXAZOLE MOIETIES
    Peter Wipf; Fiscal Year: 2005
    ..The proposed program represents a multi-dimensional effort to increase the basic knowledge of the function of marine natural products, establish new methods in heterocyclic chemistry, and identify novel pharmacophores. ..
  50. Mercury, Arsenic, and Carotid Atherosclerosis
    Eliseo Guallar; Fiscal Year: 2007
    ..Relevance: Confirmation of the role of mercury or arsenic on atherogenesis could impact current environmental and dietary public health recommendations. [unreadable] [unreadable]..
  51. Heavy Metals, Obesity and Cardiovascular Risk
    Eliseo Guallar; Fiscal Year: 2005
    ....
  52. In Vivo Study of Synapses in Alzheimer's Disease Models
    Wenbiao Gan; Fiscal Year: 2004
    ....
  53. Thalamocortical Circuits and Auditory Neocortical Maps
    DAVID VELENOVSKY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. Development and Evaluation of a VRX CT Scanner
    Frank DiBianca; Fiscal Year: 2006
    ..abstract_text> ..
  55. Hybrid Nuclear/X-ray Projection System for Mouse Imaging
    John Boone; Fiscal Year: 2005
    ..abstract_text> ..
  56. Auto-calibrating portable low-cost micro-SPECT/CT
    FRANK DIFILIPPO; Fiscal Year: 2008
    ..Many laboratories could then benefit from this device for micro-SPECT and micro-SPECT/CT. [unreadable] [unreadable] [unreadable]..
  57. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2009
    ..Molecular modeling will allow the design of candidates for more active drugs. Candidates will be evaluated in the squalene synthase assay. Collaborations for the medicinal chemistry components of the project have been arranged. ..
  58. PLASTICITY IN THE AUDITORY SYSTEM
    Russell Snyder; Fiscal Year: 2003
    ..They also provide insight into the time course and nature of the topographic spread of ( herpes viruses within the auditory system, the major cause of congenital deafness in humans. ..
  59. Novel Responses to Oxygen by Anaerobic Microorganisms
    Michael Adams; Fiscal Year: 2008
    ..abstract_text> ..
  60. Two-Photon Microscopy System
    Wenbiao Gan; Fiscal Year: 2002
    ..This device will have long-term institutional support to cover up the service contracts as well as part of a technician's salary. ..
  61. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..The information obtained in this study will be relevant to millions of children in the US and abroad who are chronically exposed to lead, cadmium, and arsenic in the environment. ..