silver

Summary

Summary: Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.

Top Publications

  1. ncbi Nanosilver: a nanoproduct in medical application
    X Chen
    Institute of Brain Research, University of Tuebingen Calwer Str 3, D 72076 Tuebingen, Germany
    Toxicol Lett 176:1-12. 2008
  2. ncbi Cytotoxicity and genotoxicity of silver nanoparticles in human cells
    P V AshaRani
    Department of Chemistry, Faculty of Science, National University of Singapore, Singapore 117543, Singapore 117597
    ACS Nano 3:279-90. 2009
  3. ncbi Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria
    Ivan Sondi
    Center for Marine and Environmental Research, Ruder Boskovic Institute, Zagreb, Croatia
    J Colloid Interface Sci 275:177-82. 2004
  4. ncbi Silver nanoparticles as a new generation of antimicrobials
    Mahendra Rai
    Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India
    Biotechnol Adv 27:76-83. 2009
  5. ncbi Negligible particle-specific antibacterial activity of silver nanoparticles
    Zong Ming Xiu
    Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, USA
    Nano Lett 12:4271-5. 2012
  6. ncbi Antimicrobial effects of silver nanoparticles
    Jun Sung Kim
    Laboratory of Toxicology, Seoul National University, Seoul, Korea
    Nanomedicine 3:95-101. 2007
  7. ncbi Silver nanoparticle applications and human health
    Maqusood Ahamed
    King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
    Clin Chim Acta 411:1841-8. 2010
  8. ncbi Antifungal effect of silver nanoparticles on dermatophytes
    Keuk Jun Kim
    Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702 701, Korea
    J Microbiol Biotechnol 18:1482-4. 2008
  9. ncbi Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549
    Rasmus Foldbjerg
    Nanoparticle Safety Group, Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Aarhus, Denmark
    Arch Toxicol 85:743-50. 2011
  10. ncbi PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes
    Rasmus Foldbjerg
    Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Bartholins Alle 2, Bygn 1260, 8000 Aarhus, Denmark
    Toxicol Lett 190:156-62. 2009

Detail Information

Publications374 found, 100 shown here

  1. ncbi Nanosilver: a nanoproduct in medical application
    X Chen
    Institute of Brain Research, University of Tuebingen Calwer Str 3, D 72076 Tuebingen, Germany
    Toxicol Lett 176:1-12. 2008
    ..Nanosilver particles are generally smaller than 100nm and contain 20-15,000 silver atoms. At nanoscale, silver exhibits remarkably unusual physical, chemical and biological properties...
  2. ncbi Cytotoxicity and genotoxicity of silver nanoparticles in human cells
    P V AshaRani
    Department of Chemistry, Faculty of Science, National University of Singapore, Singapore 117543, Singapore 117597
    ACS Nano 3:279-90. 2009
    b>Silver nanoparticles (Ag-np) are being used increasingly in wound dressings, catheters, and various household products due to their antimicrobial activity...
  3. ncbi Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria
    Ivan Sondi
    Center for Marine and Environmental Research, Ruder Boskovic Institute, Zagreb, Croatia
    J Colloid Interface Sci 275:177-82. 2004
    The antimicrobial activity of silver nanoparticles against E. coli was investigated as a model for Gram-negative bacteria...
  4. ncbi Silver nanoparticles as a new generation of antimicrobials
    Mahendra Rai
    Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India
    Biotechnol Adv 27:76-83. 2009
    b>Silver has been in use since time immemorial in the form of metallic silver, silver nitrate, silver sulfadiazine for the treatment of burns, wounds and several bacterial infections...
  5. ncbi Negligible particle-specific antibacterial activity of silver nanoparticles
    Zong Ming Xiu
    Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, USA
    Nano Lett 12:4271-5. 2012
    ..whether the AgNPs exert direct "particle-specific" effects beyond the known antimicrobial activity of released silver ions (Ag(+)). Here, we infer that Ag(+) is the definitive molecular toxicant...
  6. ncbi Antimicrobial effects of silver nanoparticles
    Jun Sung Kim
    Laboratory of Toxicology, Seoul National University, Seoul, Korea
    Nanomedicine 3:95-101. 2007
    The antimicrobial effects of silver (Ag) ion or salts are well known, but the effects of Ag nanoparticles on microorganisms and antimicrobial mechanism have not been revealed clearly...
  7. ncbi Silver nanoparticle applications and human health
    Maqusood Ahamed
    King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
    Clin Chim Acta 411:1841-8. 2010
    ..For example, silver nanoparticles (Ag NP) are used in electronics, bio-sensing, clothing, food industry, paints, sunscreens, cosmetics ..
  8. ncbi Antifungal effect of silver nanoparticles on dermatophytes
    Keuk Jun Kim
    Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702 701, Korea
    J Microbiol Biotechnol 18:1482-4. 2008
    Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated...
  9. ncbi Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549
    Rasmus Foldbjerg
    Nanoparticle Safety Group, Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Aarhus, Denmark
    Arch Toxicol 85:743-50. 2011
    Nanomaterials, especially silver nanoparticles (Ag NPs), are used in a rapidly increasing number of commercial products...
  10. ncbi PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes
    Rasmus Foldbjerg
    Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Bartholins Alle 2, Bygn 1260, 8000 Aarhus, Denmark
    Toxicol Lett 190:156-62. 2009
    The objective of the present study was to investigate the toxicity of silver nanoparticles (Ag NPs) in vitro...
  11. pmc Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli
    Sukdeb Pal
    Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Appl Environ Microbiol 73:1712-20. 2007
    In this work we investigated the antibacterial properties of differently shaped silver nanoparticles against the gram-negative bacterium Escherichia coli, both in liquid systems and on agar plates...
  12. ncbi Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species
    C Carlson
    Applied Biotechnology Branch, Human Effectiveness Directorate, Wright Patterson Air Force Base, Dayton, Ohio 45433, USA
    J Phys Chem B 112:13608-19. 2008
    ..The present study was designed to evaluate size-dependent cellular interactions of known biologically active silver nanoparticles (NPs, Ag-15 nm, Ag-30 nm, and Ag-55 nm)...
  13. ncbi The inhibitory effects of silver nanoparticles, silver ions, and silver chloride colloids on microbial growth
    Okkyoung Choi
    Department of Civil and Environmental Engineering, University of Missouri, E2509 Lafferre Hall, Columbia, MO 65211, USA
    Water Res 42:3066-74. 2008
    ..The inhibitory effects of silver nanoparticles (Ag NPs) and other important Ag species on microbial growth were evaluated using extant respirometry ..
  14. ncbi Toxicity of silver nanoparticles to Chlamydomonas reinhardtii
    Enrique Navarro
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Environ Sci Technol 42:8959-64. 2008
    b>Silver nanoparticles (AgNP) are likely to enter the aquatic environment because of their multiple uses...
  15. ncbi Nanoparticle silver released into water from commercially available sock fabrics
    Troy M Benn
    Civil and Environmental Engineering, Arizona State University, Box 5306, Tempe, Arizona 85287 5306, USA
    Environ Sci Technol 42:4133-9. 2008
    ..This paper investigates silver released from commercial clothing (socks) into water, and its fate in wastewater treatment plants (WWTPs)...
  16. ncbi A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity
    Helinor J Johnston
    Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Edinburgh, UK
    Crit Rev Toxicol 40:328-46. 2010
    This review is concerned with evaluating the toxicity associated with human exposure to silver and gold nanoparticles (NPs), due to the relative abundance of toxicity data available for these particles, when compared to other metal ..
  17. ncbi Silver nanoparticles: behaviour and effects in the aquatic environment
    Julia Fabrega
    School of Biosciences, Hatherly Laboratories, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, United Kingdom
    Environ Int 37:517-31. 2011
    ..and evaluates the present knowledge on the behaviour, the biological effects and the routes of uptake of silver nanoparticles (Ag NPs) to organisms, with considerations on the nanoparticle physicochemistry in the ecotoxicity ..
  18. ncbi Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats
    Yong Soon Kim
    Korea Environment and Merchandise Testing Institute, Incheon, Korea
    Inhal Toxicol 20:575-83. 2008
    The antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, and home products...
  19. pmc Synthesis of silver nanoparticles using Dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents
    Sougata Ghosh
    Institute of Bioinformatics and Biotechnology, University of Pune, Pune, India
    Int J Nanomedicine 7:483-96. 2012
    Development of an environmentally benign process for the synthesis of silver nanomaterials is an important aspect of current nanotechnology research...
  20. pmc Effects of silver nanoparticles on primary mixed neural cell cultures: uptake, oxidative stress and acute calcium responses
    Andrea Haase
    Department of Product Safety, German Federal Institute for Risk Assessment BfR, 10589 Berlin, Germany
    Toxicol Sci 126:457-68. 2012
    ..astrocytes and a minor proportion of oligodendrocytes to analyze the effects of well-characterized 20 and 40 nm silver nanoparticles (SNP). Similar gold nanoparticles served as control and proved inert for all endpoints tested...
  21. ncbi Silver nanoparticles: the powerful nanoweapon against multidrug-resistant bacteria
    M K Rai
    Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India
    J Appl Microbiol 112:841-52. 2012
    ..b>Silver in the form of various compounds and bhasmas have been used in Ayurveda to treat several bacterial infections ..
  22. ncbi Silver nanoparticles: green synthesis and their antimicrobial activities
    Virender K Sharma
    Chemistry Department, Florida Institute of Technology, 150 West University Boulevard, Melbourne, Florida 32901, USA
    Adv Colloid Interface Sci 145:83-96. 2009
    This review presents an overview of silver nanoparticles (Ag NPs) preparation by green synthesis approaches that have advantages over conventional methods involving chemical agents associated with environmental toxicity...
  23. ncbi Silver nanoparticles: evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cells
    Stephan Hackenberg
    Department of Oto Rhino Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    Toxicol Lett 201:27-33. 2011
    b>Silver nanoparticles (Ag-NPs) are the most frequent commercialized nanomaterial currently...
  24. ncbi In vitro toxicity of nanoparticles in BRL 3A rat liver cells
    S M Hussain
    Applied Biotechnology, Air Force Research Laboratory HEPB, Wright Patterson AFB, OH, USA
    Toxicol In Vitro 19:975-83. 2005
    ..Different sizes of nanoparticles such as silver (Ag; 15, 100 nm), molybdenum (MoO(3); 30, 150 nm), aluminum (Al; 30, 103 nm), iron oxide (Fe(3)O(4); 30, 47 nm), ..
  25. ncbi Susceptibility constants of Escherichia coli and Bacillus subtilis to silver and copper nanoparticles
    Ki Young Yoon
    Department of Mechanical Engineering, Yonsei University, 120 749 Seoul, Republic of Korea
    Sci Total Environ 373:572-5. 2007
    Nanoparticle susceptibility constants were defined and used to evaluate the antimicrobial characteristics of silver and copper nanoparticles against Escherichia coli and Bacillus subtilis. Reaction of copper nanoparticles of 100 nm with B...
  26. ncbi Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish
    Ji Eun Choi
    College of Veterinary Medicine, Seoul National University, 599 Gwanak, Gwanak, Seoul, 151 742, Republic of Korea
    Aquat Toxicol 100:151-9. 2010
    b>Silver nanoparticles (AgNPs) may induce deleterious effects in aquatic life on environmental release...
  27. ncbi Mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans
    Xinyu Yang
    Nicholas School of the Environment and Center for the Environmental Implications of NanoTechnology, Duke University, Durham, North Carolina 27708 0328, United States
    Environ Sci Technol 46:1119-27. 2012
    The rapidly increasing use of silver nanoparticles (Ag NPs) in consumer products and medical applications has raised ecological and human health concerns...
  28. ncbi Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure
    Meike Van Der Zande
    RIKILT Wageningen University and Research Centre, 6700 AE Wageningen, The Netherlands
    ACS Nano 6:7427-42. 2012
    ..the results of a 28-day oral exposure study in rats, exposed to <20 nm noncoated, or <15 nm PVP-coated silver nanoparticles ([Ag] = 90 mg/kg body weight (bw)), or AgNO(3) ([Ag] = 9 mg/kg bw), or carrier solution only...
  29. ncbi Size-dependent cellular toxicity of silver nanoparticles
    Tae Hyun Kim
    Institute of Tissue Regeneration Engineering ITREN, Dankook University, South Korea
    J Biomed Mater Res A 100:1033-43. 2012
    b>Silver nanoparticles (AgNPs) have found a variety of uses including biomedical materials; however, studies of the cytotoxicity of AgNPs by size effects are only in the beginning stage...
  30. ncbi Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: a study against gram-positive and gram-negative bacteria
    Amanulla Mohammed Fayaz
    CAS in Botany, University of Madras, Guindy Campus, Chennai, India
    Nanomedicine 6:103-9. 2010
    ..b>Silver nanoparticles (AgNPs) have been known for their inhibitory and bactericidal effect...
  31. ncbi Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster
    Maqusood Ahamed
    Department of Biology, Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH 45469, USA
    Toxicol Appl Pharmacol 242:263-9. 2010
    Due to the intensive commercial application of silver nanoparticles (Ag NPs), risk assessment of this nanoparticle is of great importance...
  32. ncbi Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles
    Jianyong Wang
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079 9502, USA
    Neurotoxicology 30:926-33. 2009
    ..This study was conducted to investigate the potential neurotoxicity of manganese (Mn), silver (Ag), and copper (Cu) nanoparticles using the dopaminergic neuronal cell line, PC12...
  33. ncbi Cellular responses induced by silver nanoparticles: In vitro studies
    S Arora
    Centre for Nanobioscience, Agharkar Research Institute, G G Agarkar Road, Pune 411004, India
    Toxicol Lett 179:93-100. 2008
    A systematic study on the in vitro interactions of 7-20 nm spherical silver nanoparticles (SNP) with HT-1080 and A431 cells was undertaken as a part of an on-going program in our laboratory to develop a topical antimicrobial agent for the ..
  34. ncbi Nanosilver as a new generation of nanoproduct in biomedical applications
    Karla Chaloupka
    Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, London, UK
    Trends Biotechnol 28:580-8. 2010
    Nanosilver (NS), comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity...
  35. ncbi The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles
    Margriet V D Z Park
    Department of Toxicogenomics, Maastricht University, 6200 MD Maastricht, The Netherlands
    Biomaterials 32:9810-7. 2011
    b>Silver nanoparticles are of interest to be used as antimicrobial agents in wound dressings and coatings in medical devices, but potential adverse effects have been reported in the literature...
  36. pmc Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats
    S Takenaka
    Institute for Inhalation Biology, GSF National Research Center for Environment and Health, Neuherberg Munich, Germany
    Environ Health Perspect 109:547-51. 2001
    ..In the first approach, pulmonary and systemic distribution of inhaled ultrafine elemental silver (EAg) particles was investigated on the basis of morphology and inductively coupled plasma mass spectrometry (ICP-..
  37. ncbi Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism
    Eun Jung Park
    College of Pharmacy, Dongduk Women s University, 23 1 Wolgok Dong, Seongbuk gu, Seoul 136 714, Republic of Korea
    Toxicol In Vitro 24:872-8. 2010
    b>Silver nanoparticles (AgNPs) are widely applied in many household products and medical uses. However, studies on the effects of AgNPs on human health and environmental implications are in the beginning stage...
  38. ncbi Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells
    Soohee Kim
    College of Veterinary Medicine, Seoul National University, Seoul 151 742, Republic of Korea
    Toxicol In Vitro 23:1076-84. 2009
    Cytotoxicity induced by silver nanoparticles (AgNPs) and the role that oxidative stress plays in this process were demonstrated in human hepatoma cells...
  39. pmc Antitumor activity of silver nanoparticles in Dalton's lymphoma ascites tumor model
    Muthu Irulappan Sriram
    Department of Biotechnology, Division of Molecular and Cellular Biology, Kalasalingam University, Tamilnadu, India
    Int J Nanomedicine 5:753-62. 2010
    ..The present study demonstrates the efficacy of biologically synthesized silver nanoparticles (AgNPs) as an antitumor agent using Dalton's lymphoma ascites (DLA) cell lines in vitro and in vivo...
  40. ncbi Ion release kinetics and particle persistence in aqueous nano-silver colloids
    Jingyu Liu
    Department of Chemistry, Division of Engineering, Institute for Molecular and Nanoscale Innovation, Brown University, Providence, Rhode Island, USA
    Environ Sci Technol 44:2169-75. 2010
    ..nanosilver (nAg) colloids as model systems, and measures their time-dependent release of dissolved silver using centrifugal ultrafiltration and atomic absorption spectroscopy...
  41. ncbi Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis
    Mei Jing Piao
    School of Medicine and Applied Radiological Science Research Institute, Jeju National University, Jeju 690 756, Republic of Korea
    Toxicol Lett 201:92-100. 2011
    b>Silver nanoparticles (AgNPs), which have well-known antimicrobial properties, are extensively used in various medical and general applications...
  42. pmc Green biosynthesis of silver nanoparticles using Curcuma longa tuber powder
    Kamyar Shameli
    Department of Chemistry, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Int J Nanomedicine 7:5603-10. 2012
    ..In this study, silver nanoparticles were biosynthesized from aqueous silver nitrate through a simple and eco-friendly route using ..
  43. ncbi Release of silver nanoparticles from outdoor facades
    Ralf Kaegi
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Environ Pollut 158:2900-5. 2010
    In this study we investigate the release of metallic silver nanoparticles (Ag-NP) from paints used for outdoor applications. A facade panel mounted on a model house was exposed to ambient weather conditions over a period of one year...
  44. ncbi Impact of silver nanoparticles on human cells: effect of particle size
    Wei Liu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
    Nanotoxicology 4:319-30. 2010
    This work investigated the cytotoxicities of three silver nanoparticles (SNPs) SNP-5, SNP-20 and SNP-50 with different sizes ( approximately 5 nm, approximately 20 nm and approximately 50 nm) using four human cell models (A549, SGC-7901, ..
  45. pmc Synthesis of silver nanoparticles by using tea leaf extract from Camellia sinensis
    Yuet Ying Loo
    Centre of Excellent for Food Safety Research, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Int J Nanomedicine 7:4263-7. 2012
    ..In this study, the synthesis of silver nanoparticles using the leaves extract of Chinese tea from Camellia sinensis is reported...
  46. ncbi Antibacterial activity of glutathione-coated silver nanoparticles against Gram positive and Gram negative bacteria
    Angelo Taglietti
    Dipartimento di Chimica, Sezione di Chimica Generale, Universita di Pavia, Pavia, Italy
    Langmuir 28:8140-8. 2012
    In the present paper, we study the mechanism of antibacterial activity of glutathione (GSH) coated silver nanoparticles (Ag NPs) on model Gram negative and Gram positive bacterial strains...
  47. ncbi Oxidative stress-related PMK-1 P38 MAPK activation as a mechanism for toxicity of silver nanoparticles to reproduction in the nematode Caenorhabditis elegans
    Dongyoung Lim
    School of Environmental Engineering, Graduate School of Energy and Environment Systems Engineering, University of Seoul, Seoul, Korea
    Environ Toxicol Chem 31:585-92. 2012
    In the present study, a toxic mechanism of silver nanoparticles (AgNPs) was investigated in the nematode, Caenorhabditis elegans, focusing on the involvement of oxidative stress in reproduction toxicity...
  48. pmc In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos
    Kerry J Lee
    Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia 23529, USA
    ACS Nano 1:133-43. 2007
    ..In this study, we directly characterized the transport of single silver nanoparticles into an in vivo model system (zebrafish embryos) and investigated their effects on early embryonic ..
  49. ncbi Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles
    Birgit K Gaiser
    Edinburgh Napier University, Edinburgh, UK
    Environ Toxicol Chem 31:144-54. 2012
    ..We compared the potential biological effects of silver (Ag; nominally 35 and 600-1,600 nm) and cerium dioxide (CeO(2;) nominally <25 nm and 1-5 µm) particles ..
  50. ncbi The progress of silver nanoparticles in the antibacterial mechanism, clinical application and cytotoxicity
    Chuangang You
    Department of Burns, 2nd Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou 310009, China
    Mol Biol Rep 39:9193-201. 2012
    ..b>Silver nanoparticles (AgNPs) has been widely used in clothing, electronics, bio-sensing, the food industry, paints, ..
  51. ncbi Antibacterial nano-structured titania coating incorporated with silver nanoparticles
    Lingzhou Zhao
    School of Stomatology, The Fourth Military Medical University, No 145 West ChangLe Road, Xi an 710032, China
    Biomaterials 32:5706-16. 2011
    ..In this study, titania nanotubes (TiO(2)-NTs) incorporated with silver (Ag) nanoparticles are fabricated on Ti implants to achieve this purpose...
  52. ncbi Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles
    Raman Preet Singh
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S A S Nagar, Punjab 160 062, India
    Toxicol Lett 213:249-59. 2012
    b>Silver nanoparticles (Ag NPs) are used in consumer products and wound dressings due to their antimicrobial properties...
  53. ncbi Characterization of translocation of silver nanoparticles and effects on whole-genome gene expression using an in vitro intestinal epithelium coculture model
    Hans Bouwmeester
    RIKILT, Institute of Food Safety, Wageningen University and Research Center, Akkermaalsbos 2, P O Box 230, 6700 AE Wageningen, The Netherlands
    ACS Nano 5:4091-103. 2011
    Applications of nanoparticles in the food sector are eminent. Silver nanoparticles are among the most frequently used, making consumer exposure to silver nanoparticles inevitable...
  54. ncbi Antifungal activity of silver nanoparticles against Candida spp
    Ales Panacek
    Department of Physical Chemistry, Faculty of Science, Palacky University, Olomouc 771 46, Czech Republic
    Biomaterials 30:6333-40. 2009
    The antifungal activity of the silver nanoparticles (NPs) prepared by the modified Tollens process was evaluated for pathogenic Candida spp...
  55. ncbi 120 years of nanosilver history: implications for policy makers
    Bernd Nowack
    Empa Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, CH 9014 St Gallen, Switzerland
    Environ Sci Technol 45:1177-83. 2011
    ..not been seen until recently and that the advances in nanotechnology opened completely new application areas for silver. However, we show in this analysis that nanosilver in the form of colloidal silver has been used for more than 100 ..
  56. ncbi In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells
    Koji Kawata
    Department of Urban and Environmental Engineering, Graduate School of Engineering, Hokkaido University, North 13, West 8, Kita ku, Sapporo 060 8628, Japan
    Environ Sci Technol 43:6046-51. 2009
    Although it has been reported that silver nanoparticles (Ag-NPs) have strong acute toxic effects to various cultured cells, the toxic effects at noncytotoxic doses are still unknown...
  57. ncbi Environmental transformations of silver nanoparticles: impact on stability and toxicity
    Clément Levard
    Surface and Aqueous Geochemistry Group, Department of Geological and Environmental Sciences, Stanford University, Stanford, California 94305 2115, United States
    Environ Sci Technol 46:6900-14. 2012
    b>Silver nanoparticles (Ag-NPs) readily transform in the environment, which modifies their properties and alters their transport, fate, and toxicity...
  58. ncbi Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activity
    Ales Panacek
    Department of Physical Chemistry, Palacky University, Svobody 26, 771 46 Olomouc, Czech Republic
    J Phys Chem B 110:16248-53. 2006
    A one-step simple synthesis of silver colloid nanoparticles with controllable sizes is presented. In this synthesis, reduction of [Ag(NH(3))(2)](+) complex cation by four saccharides was performed...
  59. ncbi Evaluation of the toxic impact of silver nanoparticles on Japanese medaka (Oryzias latipes)
    Yun Ju Chae
    College of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    Aquat Toxicol 94:320-7. 2009
    ..In this study, therefore, we investigated the health and environmental impact of silver nanoparticles (Ag-NPs) on Japanese Medaka by studying changes in the expression of stress-related genes using real ..
  60. ncbi Genotoxicity of silver nanoparticles in Allium cepa
    Mamta Kumari
    Nanobio Medicine Group, School of Bio Sciences and Technology, VIT University, Vellore 632014, India
    Sci Total Environ 407:5243-6. 2009
    ..This study aims to investigate cytotoxic and genotoxic impacts of silver nanoparticles using root tip cells of Allium cepa as an indicator organism. A...
  61. pmc Bactericidal actions of a silver ion solution on Escherichia coli, studied by energy-filtering transmission electron microscopy and proteomic analysis
    Mikihiro Yamanaka
    Research Dept 8, Devices Technology Research Laboratories, Corporate Research and Development Group, SHARP Corporation, 2613 1, Ichinomoto cho, Tenri, Nara, Japan
    Appl Environ Microbiol 71:7589-93. 2005
    Bactericidal actions of the silver ion on Escherichia coli as a model microorganism were studied using energy-filtering transmission electron microscopy (EFTEM), two-dimensional electrophoresis (2-DE), and matrix-assisted laser desorption ..
  62. ncbi Modeled environmental concentrations of engineered nanomaterials (TiO(2), ZnO, Ag, CNT, Fullerenes) for different regions
    Fadri Gottschalk
    Empa, Swiss Federal Laboratories for Materials Testing and Research, Technology and Society Laboratory, CH 9014 St Gallen, Switzerland
    Environ Sci Technol 43:9216-22. 2009
    ..For the other environmental compartments for which ecotoxicological data were available, no risks to organisms are presently expected...
  63. ncbi Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes
    Hung Jen Yen
    Department of Chemical Engineering, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 402, Taiwan, R O C
    Small 5:1553-61. 2009
    ....
  64. ncbi Surface charge-dependent toxicity of silver nanoparticles
    Amro M El Badawy
    Department of Civil and Environmental Engineering, University of Cincinnati, Cincinnati, Ohio, USA
    Environ Sci Technol 45:283-7. 2011
    As a result of the extensive number of applications of silver nanoparticles (AgNPs), their potential impacts, once released into the environment, are of concern...
  65. pmc Memecylon edule leaf extract mediated green synthesis of silver and gold nanoparticles
    Tamizhamudu Elavazhagan
    Centre for Interdisciplinary Research, Directorate of Research, SRM University, Kattankulathur, Tamilnadu, India
    Int J Nanomedicine 6:1265-78. 2011
    We used an aqueous leaf extract of Memecylon edule (Melastomataceae) to synthesize silver and gold nanoparticles. To our knowledge, this is the first report where M...
  66. pmc Shape matters: effects of silver nanospheres and wires on human alveolar epithelial cells
    Linda C Stoehr
    Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria
    Part Fibre Toxicol 8:36. 2011
    ..We investigated the toxic and immunotoxic effects of silver wires (length: 1...
  67. ncbi Antibacterial effect of silver nanoparticles on Staphylococcus aureus
    Wen Ru Li
    Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China
    Biometals 24:135-41. 2011
    The antibacterial activity and mechanism of silver nanoparticles (Ag-NPs) on Staphylococcus aureus ATCC 6538P were investigated in this study. The experiment results showed the minimum bactericidal concentration (MBC) of Ag-NPs to S...
  68. ncbi Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells
    Ha Ryong Kim
    School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, South Korea
    Mutat Res 726:129-35. 2011
    Many classes of silver nanoparticles (Ag-NPs) have been synthesized and widely applied, but the genotoxicity of Ag-NPs and the factors leading to genotoxicity remain unknown...
  69. pmc Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli
    Woo Kyung Jung
    Department of Microbiology, KRF Zoonotic Disease Priority Research Institute, College of Veterinary Medicine, Seoul National University, Sillim dong, Gwanak Gu, Seoul 151 742, Korea
    Appl Environ Microbiol 74:2171-8. 2008
    The antibacterial effect and mechanism of action of a silver ion solution that was electrically generated were investigated for Staphylococcus aureus and Escherichia coli by analyzing the growth, morphology, and ultrastructure of the ..
  70. ncbi Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells
    Nana Asare
    Division of Environmental Medicine, Norwegian Institute of Public Health, P O Box 4404 Nydalen, N 0403 Oslo, Norway
    Toxicology 291:65-72. 2012
    ..In this study, we examined effects of silver particles of nano- (20nm) and submicron- (200nm) size, and titanium dioxide nanoparticles (TiO(2)-NPs; 21nm), with ..
  71. ncbi Ecotoxicity of silver nanoparticles on the soil nematode Caenorhabditis elegans using functional ecotoxicogenomics
    Ji Yeon Roh
    Faculty of Environmental Engineering, College of Urban Science, University of Seoul, 90 Jeonnong dong, Dongdaemun Gu, Seoul 130 743, Korea
    Environ Sci Technol 43:3933-40. 2009
    In the present study, the ecotoxicity of silver nanoparticles (AgNPs) was investigated in Caenorhabditis elegans using survival, growth, and reproduction, as the ecotoxicological endpoints, as well as stress response gene expression...
  72. ncbi Silver nanospheres are cytotoxic and genotoxic to fish cells
    John Pierce Wise
    Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, 96 Falmouth St, P O Box 9300, Portland, ME 04104, USA
    Aquat Toxicol 97:34-41. 2010
    ..For example, silver nanoparticles are used in commercial products for their antibacterial and antifungal properties...
  73. ncbi Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos
    P V AshaRani
    Department of Chemistry, National University of Singapore, Singapore
    Nanotoxicology 5:43-54. 2011
    ..Toxicity assays of silver, gold, and platinum nanoparticles, using zebrafish embryos to study their developmental effects were carried out...
  74. pmc Antimicrobial activity and the mechanism of silver nanoparticle thermosensitive gel
    Meiwan Chen
    Research and Development Center of Pharmaceutical Engineering, School of Pharmaceutical Sciences, Sun Yatsen University, Guangzhou, China
    Int J Nanomedicine 6:2873-7. 2011
    The purpose of the present study was to elucidate the antimicrobial activity and mechanism of silver nanoparticles incorporated into thermosensitive gel (S-T-Gel) on Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
  75. ncbi Uptake and intracellular distribution of silver nanoparticles in human mesenchymal stem cells
    C Greulich
    Bergmannsheil University Hospital Surgical Research, Ruhr University Bochum, Germany
    Acta Biomater 7:347-54. 2011
    b>Silver nanoparticles (Ag-NP) are widely used due to their well-known antibacterial effects. In medicine Ag-NP have found applications as wound dressings, surgical instruments and bone substitute biomaterials, e.g...
  76. ncbi The effect of agglomeration state of silver and titanium dioxide nanoparticles on cellular response of HepG2, A549 and THP-1 cells
    Anna Lankoff
    Center for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, 16 Dorodna Str, 03 195 Warsaw, Poland
    Toxicol Lett 208:197-213. 2012
    ..The motivation of this study was to examine how the agglomeration/aggregation state of silver (20nm and 200nm) and titanium dioxide (21nm) nanoparticles may affect the kinetics of cellular binding/uptake and ..
  77. pmc Green synthesis of silver/montmorillonite/chitosan bionanocomposites using the UV irradiation method and evaluation of antibacterial activity
    Kamyar Shameli
    Department of Chemistry, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Int J Nanomedicine 5:875-87. 2010
    In this study, silver nanoparticles (Ag-NPs) were synthesized using a green physical synthetic route into the lamellar space of montmorillonite (MMT)/chitosan (Cts) utilizing the ultraviolet (UV) irradiation reduction method in the ..
  78. ncbi DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells
    Maqusood Ahamed
    Department of Biology, Centre for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH 45469, USA
    Toxicol Appl Pharmacol 233:404-10. 2008
    b>Silver nanoparticles (Ag NPs) have recently received much attention for their possible applications in biotechnology and life sciences...
  79. ncbi Topical delivery of silver nanoparticles promotes wound healing
    Jun Tian
    Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    ChemMedChem 2:129-36. 2007
    ..The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds...
  80. ncbi Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus aureus and Escherichia coli
    Ahmad R Shahverdi
    Department of Pharmaceutical Biotechnology and Medical Nanotechnology Research Center, Faculty of Pharmacy, Medical Sciences University of Tehran, Tehran, Iran
    Nanomedicine 3:168-71. 2007
    b>Silver nanoparticles (Ag-NPs) have been known to have inhibitory and bactericidal effects. Resistance to antimicrobial agents by pathogenic bacteria has emerged in recent years and is a major health problem...
  81. ncbi Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract
    S Prathap Chandran
    Nanoscience Group, Materials Chemistry Division, Biochemical Sciences Division, National Chemical Laboratory, Pune 411008, India
    Biotechnol Prog 22:577-83. 2006
    Biogenic gold nanotriangles and spherical silver nanoparticles were synthesized by a simple procedure using Aloe vera leaf extract as the reducing agent...
  82. ncbi Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos
    Ofek Bar-Ilan
    Division of Pharmaceutical Sciences, University of Wisconsin Madison, 777 Highland Ave, Madison, WI 53705 2222, USA
    Small 5:1897-910. 2009
    ..Using colloidal silver (cAg) and gold nanoparticles (cAu) in a panoply of sizes (3, 10, 50, and 100 nm) and a semiquantitative scoring ..
  83. ncbi Antibacterial properties of Ag nanoparticle loaded multilayers and formation of magnetically directed antibacterial microparticles
    Daeyeon Lee
    Department of Chemical Engineering and the Center for Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Langmuir 21:9651-9. 2005
    ..e., the square of the zone of inhibition (ZoI) depended linearly on the logarithm of the thickness of the silver-loaded films)...
  84. ncbi Comparison of automated silver enhanced in situ hybridisation (SISH) and fluorescence ISH (FISH) for the validation of HER2 gene status in breast carcinoma according to the guidelines of the American Society of Clinical Oncology and the College of America
    M Dietel
    Institute of Pathology, Charite University Medicine Berlin, Berlin, Germany
    Virchows Arch 451:19-25. 2007
    ..gene amplification in invasive breast cancer determined by fluorescence in situ hybridisation (FISH) and a new silver enhanced in situ hybridisation (SISH) technique...
  85. ncbi Biological properties of "naked" metal nanoparticles
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Adv Drug Deliv Rev 60:1289-306. 2008
    ..demonstrated that the electromagnetic, optical and catalytic properties of noble-metal nanoparticles such as gold, silver and platinum, are strongly influenced by shape and size...
  86. ncbi Silver nanoparticles: partial oxidation and antibacterial activities
    Chun Nam Lok
    The Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    J Biol Inorg Chem 12:527-34. 2007
    The physical and chemical properties of silver nanoparticles that are responsible for their antimicrobial activities have been studied with spherical silver nanoparticles (average diameter approximately 9 nm) synthesized by the ..
  87. ncbi The kinetics of the tissue distribution of silver nanoparticles of different sizes
    D P K Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 31:8350-61. 2010
    Blood kinetics and tissue distribution of 20, 80 and 110 nm silver nanoparticles were investigated in rats up to 16 days after intravenous administration once daily for 5 consecutive days...
  88. ncbi Self-assembly of large-scale and ultrathin silver nanoplate films with tunable plasmon resonance properties
    Xiao Yang Zhang
    School of Electronic Science and Engineering, Southeast University, and Key Laboratory of Micro Inertial Instrument and Advanced Navigation Technology, Ministry of Education, Nanjing, 210096, China
    ACS Nano 5:9082-92. 2011
    ..the production of large-scale metallic thin films with tunable plasmonic properties assembled from size-selected silver nanoplates (SNPs)...
  89. ncbi Acute and chronic toxicity effects of silver nanoparticles (NPs) on Drosophila melanogaster
    Ales Panacek
    Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University, 17 listopadu 12, 77146 Olomouc, Czech Republic
    Environ Sci Technol 45:4974-9. 2011
    ..the first complex study focused on in vivo evaluation of the acute and chronic toxic effects and toxic limits of silver nanoparticles (NPs) on the eukaryotic organism Drosophila melanogaster...
  90. pmc Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
    Sunhyae Jang
    Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Medical School, Daesadong, Daejeon, South Korea
    Int J Nanomedicine 7:1329-43. 2012
    The anti-inflammatory action of silver nanoparticles (NPs) has been reported in a murine model of asthma in a previous study...
  91. ncbi Silver nanoparticles in therapeutics: development of an antimicrobial gel formulation for topical use
    Jaya Jain
    Centre for Nanobioscience, Agharkar Research Institute, G G Agarkar Road, Pune 411 004, India
    Mol Pharm 6:1388-401. 2009
    b>Silver is an effective antimicrobial agent with low toxicity, which is important especially in the treatment of burn wounds where transient bacteremia is prevalent and its fast control is essential...
  92. ncbi Cytotoxic effect and apoptosis induction by silver nanoparticles in HeLa cells
    Nobuhiko Miura
    Division of Health Effects Research, National Institute of Occupational Safety and Health JNIOSH, Kawasaki 214 8585, Japan
    Biochem Biophys Res Commun 390:733-7. 2009
    ..In comparison with silver ion, there is serious lacking of information concerning the biological effects of nanoAg...
  93. ncbi Rapid biological synthesis of silver nanoparticles using plant leaf extracts
    Jae Yong Song
    Department of Chemical Engineering, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
    Bioprocess Biosyst Eng 32:79-84. 2009
    ..Persimmon, Ginkgo, Magnolia and Platanus) were used and compared for their extracellular synthesis of metallic silver nanoparticles...
  94. ncbi The disruption of bacterial membrane integrity through ROS generation induced by nanohybrids of silver and clay
    Hong Lin Su
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan
    Biomaterials 30:5979-87. 2009
    Nanohybrids, synthesized via silver nitrate reduction in the presence of silicate clay, exhibit a high potency against bacterial growth...
  95. ncbi Strain specificity in antimicrobial activity of silver and copper nanoparticles
    Jayesh P Ruparelia
    Centre for Environmental Science and Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India
    Acta Biomater 4:707-16. 2008
    The antimicrobial properties of silver and copper nanoparticles were investigated using Escherichia coli (four strains), Bacillus subtilis and Staphylococcus aureus (three strains)...
  96. ncbi Proteomic analysis of the mode of antibacterial action of silver nanoparticles
    Chun Nam Lok
    Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Proteome Res 5:916-24. 2006
    b>Silver nanoparticles (nano-Ag) are potent and broad-spectrum antimicrobial agents. In this study, spherical nano-Ag (average diameter = 9...
  97. pmc Mode of bactericidal action of silver zeolite and its comparison with that of silver nitrate
    Yoshinobu Matsumura
    Department of Biotechnology, Kansai University, 3 3 35 Yamate cho, Suita 564 8680, Japan
    Appl Environ Microbiol 69:4278-81. 2003
    The properties of the bactericidal action of silver zeolite as affected by inorganic salts and ion chelators were similar to those of silver nitrate...
  98. ncbi Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans
    Joel N Meyer
    Nicholas School of the Environment and Center for the Environmental Implications of NanoTechnology, Duke University, Durham, NC 27708 0328, United States
    Aquat Toxicol 100:140-50. 2010
    b>Silver nanoparticles (AgNPs) are frequently used as antimicrobials...
  99. pmc Subchronic oral toxicity of silver nanoparticles
    Yong Soon Kim
    Korea Environment and Merchandise Testing Institute, Incheon, Korea
    Part Fibre Toxicol 7:20. 2010
    The antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, consumer, medicinal, pesticide, and home products; however, silver nanoparticles remain a controversial area of research ..
  100. ncbi Size dependent and reactive oxygen species related nanosilver toxicity to nitrifying bacteria
    Okkyoung Choi
    Department of Civil and Environmental Engineering, University of Missouri, Columbia, Missouri 65211, USA
    Environ Sci Technol 42:4583-8. 2008
    ..Furthermore, inhibition by Ag nanoparticles as well as other forms of silver (AgCl colloid and Ag+ ion) correlated well with the intracellular ROS concentrations, but not with the ..
  101. ncbi Fractionating nanosilver: importance for determining toxicity to aquatic test organisms
    Alan J Kennedy
    US Army Engineer Research and Development Center, Vicksburg, Mississippi 39180, United States
    Environ Sci Technol 44:9571-7. 2010
    ..When 48-h lethal median concentrations (LC50) were expressed as total silver, both D. magna and P. promelas were significantly more sensitive to ionic silver (Ag(+)) as AgNO(3) (mean LC50 = 1...

Research Grants81

  1. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    ..Amalgam is an alloy of mercury with another metal (silver) used traditionally by dentists to fill cavities in teeth...
  2. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..The proposed device can be processed and assembled in the US at almost half the cost of current silver coated Foley catheters', and could potentially prevent ten thousand deaths per year due to CAUTIs...
  3. Dual-Receptor Targeted Nanoparticles for Photodynamic Therapy of Brain Cancer
    Ann Marie Broome; Fiscal Year: 2013
    ..We will examine the uptake and localization of targeted NPs using various experimental techniques, including silver enhancement immunohistochemistry, real time confocal laser scanning microscopy, and transmission electron ..
  4. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
    ..Rawson,N.E. (2000). Human olfaction. In The neurobiology of taste and smell, T.E. Finger, W.L. Silver, and D. Restrepo, eds. (New York: Wiley-Liss), pp. 257-284. Turetsky,B.I., Moberg,P.J., Owzar,K., Johnson,S.C...
  5. Inhibition of S14 by Conjugated Linoleic Acid in Advanced Solid Tumor Patients
    Raymond P Perez; Fiscal Year: 2010
    ..Pharmacokinetic sampling and biopsies are performed on days 1 and 15, with quantification of plasma CLA levels by silver- ion HPLC. Molecular pharmacodynamic (PD) endpoints are assayed by RT-PCR and/or immuno- histochemistry...
  6. Expression signatures of TB-specific memory responses within the human lung
    Richard F Silver; Fiscal Year: 2013
    ..collaboration of investigators with experience in bronchoscopy-based studies of human immunity to Mtb (Richard Silver, Case Western Reserve University) assessment of immune responses to experimental TB vaccination (Daniel Hoft, ..
  7. Rabies virus maintenance in bat populations
    APRIL DAWN DAVIS; Fiscal Year: 2013
    ..of bats will be included in this proposal: big brown bats (Eptesicus fuscus), little brown bats (Myotis spp), and silver hair bats (Lasionycteris noctivagans)...
  8. Soft Metal, Disulfide, and Cysteine Stresses in Escherichia coli
    James A Imlay; Fiscal Year: 2013
    ..Some of these metals- notably silver and mercury-have a long history of being used as antibiotics...
  9. Effects of Bisphenol A Exposure on Genomic Imprinting in the Mouse
    Martha Susiarjo; Fiscal Year: 2012
    ..a number of human diseases, including Beckwith-Wiedemann Syndrome, Prader-Willi Syndrome, Angelman Syndrome and Silver-Russell Syndrome...
  10. Reducing wound bioburden and biofilm formation using a nanoscale wound surface en
    Jonathan F McAnulty; Fiscal Year: 2013
    ..loaded with antibiofilm agents in a nanoscopic thin film, manufactured of polyelectrolyte multilayers containing silver nanoparticles, that is used to re-engineer the wound surface to increase its resistance to microbial colonization ..
  11. Immunotherapy against tauopathy in a transgenic mouse model
    David Morgan; Fiscal Year: 2013
    ..tau-5, mid domain epitope IgG1, not phosphorylation specific) can reduce histologically identified tau and reduce silver stained deposits identified by Gallyas. We wish to pursue this initial observation to address 4 specific aims...
  12. College of Medicine Phoenix Campus Vivarium Phase I Construction
    William M Crist; Fiscal Year: 2010
    ..the Initiative on Climate Change, signed by the participating University Presidents, this project will pursue LEED Silver certification with sustainability concepts, including recycling, energy efficiency, reduced water use and ..
  13. Interconnectivity between genome packagaing and other viral functions
    A L Rao; Fiscal Year: 2010
    ..and virus assembly sites at the sub-cellular level will be investigated by electron microscopy using a novel Silver Enhancement-Controlled Sequential Immunogold technique (SECSI)...
  14. NIR Light-Activated Nanoparticles for Drug and Gene Delivery
    JOSEPH ANTHONY ZASADZINSKI; Fiscal Year: 2013
    ..New silver nanoshells and gold and silver nanorods will be synthesized to probe other regions of the NIR spectrum and provide ..
  15. Immunopathology of the Pneumocystis Life Cycle Stages
    Melanie T Cushion; Fiscal Year: 2013
    ..comprised mostly of B-1,3 glucan;is larger (5-8um vs 1-4um);and stains with the fungal wall stain, methenamine silver. Cyst formation is thought to result from mating of trophs, but the interplay between the asexual and sexual ..
  16. Epigenetic Regulation of Imprinting in Mouse Embryo
    Marisa S Bartolomei; Fiscal Year: 2012
    ..mutations observed in various imprinting syndromes including Beckwith-Wiedemann, Prader-Willi, Angelman and Silver-Russell Syndromes...
  17. Development of a repetitive concussion traumatic brain injury model
    Michael J Whalen; Fiscal Year: 2013
    ..37 J) assessed in Aim 1: Acute cellular injury and death (Fluoro Jade B, TUNEL, in vivo propidium iodide, and silver staining), axonal injury (APP histochemistry, electron microscopy, and silver staining), and neuroinflammation (..
  18. SEQUENCES CONTROLLING H19 GENE IMPRINTING
    Marisa S Bartolomei; Fiscal Year: 2013
    ..plays a role in the transmission of a number of human disorders, including Beckwith-Wiedemann Syndrome (BWS), Silver-Russell Syndrome (SRS), Prader-Willi Syndrome and Angelman Syndrome, in that the sex of the parent that transmits ..
  19. Alcohol and Development of the Prefrontal Cortex
    LEON GARLAND COLEMAN; Fiscal Year: 2011
    ..days (PND) 7 and 14 as well as through adolescence (PND28-38) on cell death markers (activated caspase 3 and silver stain) just after treatment;and to examine adult frontal cortical structure following prenatal treatment using ..
  20. Delayed Onset of Biofilm Formation and CAUTI with Superhydrophobic Catheters
    Sanjiv Lalwani; Fiscal Year: 2011
    ..than intraluminally, have been directed at developing antimicrobial action on the catheter surface: (i) silver alloy urinary catheters are prone to antimicrobial resistance development;(ii) antimicrobial- impregnated ..
  21. Novel Polymer Coatings to Prevent Biofilms on Urinary Stents and Catheters
    JEFFREY LAWRENCE DALSIN; Fiscal Year: 2011
    ..Various surface modifications to urinary devices have been developed to prevent bacterial adhesion, such as silver-coated surfaces, control-release antibiotics, and surface modification to change hydrophobicity...
  22. Reduction of Tunneled Dialysis Catheter Dysfunction Via Long Term Nitric Oxide Re
    Prabir Roy-Chaudhury; Fiscal Year: 2013
    ..47,000 to the cost of care and a 14.6 d increase in length of stay. Current heparin, silver impregnated, or antibiotic coated TDCs are either expensive, non-effective, or suffer from mechanical breakdown ..
  23. Polysaccharide Ecocomposite Materials: Recyclable Synthesis and Applications
    Chieu D Tran; Fiscal Year: 2012
    ..e., HemCon bandage (a bandage based on CS), Iodoflex pad (a bandage with iodine) and Silvasorb sheet (bandage with silver)...
  24. Role of Neuroinflammation in Behavioral Deficits Resulting from Chronic Alcohol
    Clare J Wilhelm; Fiscal Year: 2013
    ..immune cells, gene expression profiling to determine changes in neuronal integrity, and hematoxylin and eosin and silver staining to examine neurotoxicity...
  25. Pharmacogenomics of Preterm Birth Prevention and Treatment
    TRACY ANN MANUCK; Fiscal Year: 2013
    ..These goals will be achieved through a combination of regular meetings with mentors (Drs. Michael Varner, Robert Silver, and Lynn Jorde), completion of several research certificates and courses, collaboration with SPTB experts ..
  26. Use of Silver Nanostructures on Microtransponders in Ultra-sensitive Assay
    Wlodek Mandecki; Fiscal Year: 2011
    ..is to increase the sensitivity of microtransponder-based multiplexed bioassays by (1) introducing a coating with silver nanostructures onto the microtransponders (MTPs) to enhance fluorescence emission, and (2) improving the ..
  27. Center for Biophysical Assessment and Risk Management Following Irradiation
    Paul Okunieff; Fiscal Year: 2009
    ..carbonate of tooth enamel (or bone) and in sulfate of hair and nails, much in the same way as film dosimetry uses silver nitrate...
  28. Risk Stratification in Older Persons with Acute Myocardial Infarction: SILVER-AMI
    Sarwat I Chaudhry; Fiscal Year: 2013
    ..mixed- methods study (combining both quantitative and qualitative methodology) of the older AMI population, SILVER- AMI...
  29. Biosensing Devices for Cytotoxic and Genotoxic Assessment of Nanomaterials
    Chenzhong Li; Fiscal Year: 2012
    ..as they show results only at a final time point The toxicity of several engineered nanomaterials such as gold, silver, graphene, etc...
  30. Engineering the Corneal Wound Bed to Promote Healing
    SARA MICHELLE THOMASY; Fiscal Year: 2013
    ..Antimicrobial factors such as silver and human b-defensin-3, a naturally occurring host peptide, will be used to test the novel proposition that their ..
  31. The Role of the Maternal and Developmental Environments in Adult Phenotype
    JENNIFER GRINDSTAFF; Fiscal Year: 2010
    ..The second hypothesis, the silver spoon effect, instead proposes that individuals from high quality developmental environments always have higher ..
  32. Cancer Genome Characterization Center at Johns Hopkins
    Stephen Baylin; Fiscal Year: 2009
    ..and use machine learning to derive systems biology correlates among available TCGA data, all designed for CaBIG silver or better compliance...
  33. Sub-Wavelength Imaging of Intracellular Metal Ions
    Joseph R Lakowicz; Fiscal Year: 2010
    ..Depending upon the intended wavelength range the structures will be made out of gold, silver or aluminum, which will extend the wavelength range from the UV to the NIR...
  34. The Libby Community Childhood Health Investigation and Exposure Follow-Up Study (
    Grace LeMasters; Fiscal Year: 2012
    ..LA is attractive to children because of its silver sparkles and ability to pop when heated...
  35. A Melamine Field Sensor for Surety Control of Dairy Products
    Kevin M Spencer; Fiscal Year: 2010
    ..The SERS sensors, vapor deposited silver films with subsequent electrochemical roughening, are inexpensive to make and can be used in complex matrices like ..
  36. Antibacterial Molecular Coatings Pre-Fabricated for Biologic Wound Dressings
    Ankit Agarwal; Fiscal Year: 2012
    ..wound care is the fabrication of biologic dressings that incorporate broad-spectrum antibacterial agents such as silver. Silver formulations are widely used in hospitals for treatment of wound infections...
  37. ADHESIN-BASED NANOTHERAPEUTICS IN URINARY TRACT INFECTION
    DAVID ALAN HUNSTAD; Fiscal Year: 2013
    ..Third, we will optimize the loading of silver cation and structurally modifiable silver carbene antimicrobials into the NPs...
  38. Institute of RNA Science and Technology (IRNAST)
    Edelgard Wulfert; Fiscal Year: 2010
    ..25 jobs on-site, and the finished Institute will surpass the Leadership in Energy and Environmental Design Systems silver level of sustainable green building and development practices...
  39. ATF2 in melanoma development and progression
    ZE apos EV A RONAI; Fiscal Year: 2012
    ..Initial analysis of melanocytes identified a set of pigmentation genes, including MITF, MC1R, Silver, DCT and TYRP1, whose expression is altered in the absence of functional ATF2...
  40. SEQUENCES CONTROLLING H19 GENE IMPRINTING
    Marisa S Bartolomei; Fiscal Year: 2010
    ..genetic diseases Beckwith-Wiedemann Syndrome, Prader-Willi Syndrome and Angelman Syndrome, a number of cases of Silver-Russell Syndrome and for cancers such as Wilms'tumor...
  41. Infection resistant surface for ventricular assist device (VAD) transcutaneous dr
    PATRICK THOMAS CAHALAN; Fiscal Year: 2013
    ..innovation of the surface lies in going beyond the partial solution of acute antimicrobial release (such as the silver-impregnated gauze typically used in VAD transcutaneous driveline applications) to an engineered surface that also ..
  42. Texas A&M University Interdisciplinary Life Sciences Building Build-Out
    JEFFREY RANDALL SEEMANN; Fiscal Year: 2010
    ..state-of-the-art facility was designed using green and sustainable principles and was constructed to meet LEED "Silver" Certification standards...
  43. Metal ion export in bacteria
    Edward W Yu; Fiscal Year: 2013
    ..The primary target of this proposal is the E. coli CusABC efflux system that recognizes and extrudes silver and copper ions out of the bacterial cell. CusA consists of 1,047 amino acid residues...
  44. Improved Batteries for Implantable Cardiac Defibrillators
    Kenneth J Takeuchi; Fiscal Year: 2012
    ..The current benchmark power source technology is lithium/silver vanadium oxide (Li/SVO) developed >20 years ago...
  45. Scientific Basis of Iodine-Fluoride Varnish in Preventing Dental Caries
    R MIKE SHIRTCLIFF; Fiscal Year: 2013
    ..The research will be conducted by the small business firm ADP Silver Dental Arrest, LLC, in collaboration with experienced researchers at the University of Washington Northwest Center ..
  46. FUNCTIONAL MORPHOLOGY OF TASTE BUDS
    John C Kinnamon; Fiscal Year: 2012
    ..in taste buds by using immunofluorescence and immunoelectron microscopy with colloidal gold labeling or silver-intensified nanogold immunoelectron microscopy to elucidate the nature of functional contacts in taste buds of the ..
  47. Prefrontal Modulation of Cognitive Deficits
    MEGAN MARIE MARTIN ST PETERS; Fiscal Year: 2010
    ..1994;Silver and Feldman, 2005)...
  48. Physicians'Health Study II: Prevention Trial of Vitamins
    J Michael Gaziano; Fiscal Year: 2011
    ..DSMB), this application seeks funding to extend randomized treatment and follow-up for the multivitamin (Centrum Silver) component of the Physicians Health Study II, an ongoing randomized, double-blind, placebo- controlled trial of ..
  49. Cytoxic and Genotoxic Effects of Manufactured Nanoparticles on Stem Cells
    Yiling Hong; Fiscal Year: 2011
    ..are, or will be, prominently used in commercially available products: carbon NPs (car wax, fuel lines, cosmetics), silver NPs (antimicrobial wound dressings, odor-reducing socks), titanium dioxide NPs (sunscreens, paints), and zinc ..
  50. Long-Term Broad-Spectrum Prevention of Implant-Related Infections
    Kyumin Whang; Fiscal Year: 2012
    ..As an antimicrobial agent, silver has been extensively researched because of its exceptional safety and efficacy...
  51. AIDS Clinical Trials Group Network
    Daniel R Kuritzkes; Fiscal Year: 2010
    ..The ACTG Operations Center, located in Silver Spring, MD, provides key operational, administrative, and fiscal support...
  52. AIDS Clinical Trials Group Network
    Daniel R Kuritzkes; Fiscal Year: 2013
    ..The ACTG Operations Center, located in Silver Spring, MD, provides key operational, administrative, and fiscal support...
  53. Construction Grant 8th Floor BRB
    E Albert Reece; Fiscal Year: 2010
    ..The UMB SOM anticipates this project will be certified as a LEEDS silver project by incorporating sustainable methods in the design and construction of this renovation...
  54. A Clonable High-Density for 3-D Electron Microscopy of Cellular Structures
    Andreas Hoenger; Fiscal Year: 2010
    ..Metallothionein-tagged cellular components in vitrified sections of intact cells, liklely with the use of silver-enhancement will also be tested...
  55. Antimicrobial effect of a new class of light resistant silver(I) complexes Adhesi
    MARIANNA PATRAUCHAN; Fiscal Year: 2013
    ..Our central hypothesis is that non-antibiotic, UV and visible light resistant silver(I) complexes with strong antimicrobial effect offer such benefits when used either as an adjunct or alternative ..
  56. Oxarane-Acrylate System to Double the Clinical Service Life of Restorative Resins
    H Ralph Rawls; Fiscal Year: 2013
    ..one-step (primer-less), "smart," antimicrobial bonding resin with in situ-generated, colorless and color stable, silver nanoparticles (AgNPs)...
  57. Ventana Medical Systems Discovery XT
    Luis Chiriboga; Fiscal Year: 2013
    ..and dual color immunohistochemistry (IHC), immunoflorescence (IF), chromogenic (CISH), fluorescent (FISH) and silver (SISH) in situ hybridization (ISH) as well as dual IHC/ISH and IHC/SISH applications...
  58. Low cost custom synthesis microarray
    Erdogan Gulari; Fiscal Year: 2011
    ..We also showed that using silver staining amplification it was possible to make microarrays which could be read by the eye and provide simple "yes" ..
  59. Treatment of Wound Infection with Novel Uncharged Silver Carbene Complexes
    David J Vachon; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Three novel uncharged silver carbene microbicides that have been shown to be effective against a wide variety of pathogens will be formulated into two different ointment formulations and tested in an ..
  60. Translational Research at PENN: Advancing Cures through Interdisciplinary Science
    Glen N Gaulton; Fiscal Year: 2010
    ..In support of the ARRA, construction on this LEED Silver certified project could initiate immediately upon award issue and design approval...
  61. Genetic architecture of the mammalian (canid) skeleton: The silver fox (V. vulpes
    Lyudmila N Trut; Fiscal Year: 2010
    ..This is a continuation of a pilot project to identify genetic loci that regulate behavior and morphology in the Silver Fox, V. Vulves...
  62. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2001
    ..details of muscle structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor endplate types, and ..
  63. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2003
    ..details of muscle structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor endplate types, and ..
  64. Developing and Evaluating Online Education to Improve Older Adults'Health Inform
    Arlene Fink; Fiscal Year: 2011
    ..The program will be designed for current internet users who are 55 years of age and older in order to capture the "silver tsunami" of boomers whose internet use resembles that of people in their 30's...
  65. IN SITU ANALYSIS OF HUMAN PLAQUE FORMATION
    Greg Germaine; Fiscal Year: 1991
    ..by (i) tagging with transition elements via chelate conjugates and (ii) labeling with sized colloidal gold, silver and metal oxides...
  66. REDOX GLYCOSIDATION
    ANTHONY BARRETT; Fiscal Year: 1992
    ..Reductive methylation and silver mediated cyclization of these species will be used to prepare di- and higher oligosaccharides...
  67. FLUORESCENT AND LARGE METAL CLUSTER COMBINATION PROBES
    Richard Powell; Fiscal Year: 1999
    ..initial phase, anti-IgG antibody-conjugated probes would be evaluated by immunoblotting serially diluted IgG (with silver enhancement) and as secondary reagents for immunofluorescence labeling of surface red blood cell antigens...
  68. Integrated EEG/NIR Sensor System for Infants
    Catherine Poulsen; Fiscal Year: 2009
    ..In addition to housing silver-silver chloride electrodes for EEG acquisition, each source opto-electrode will contain miniature dual-wavelength ..
  69. Neurons in the subcallosal sling
    Linda Richards; Fiscal Year: 2005
    The glial sling was first described by Silver and colleagues in the early 1980's as a population of glioblast cells that arise in the medial aspect of the lateral ventricles...
  70. DEVELOPMENTAL CHANGES IN HEART AND MUSCLE PFK ISOZYMES
    George Dunaway; Fiscal Year: 1991
    ..are present in the native PFK isozyme pools employing SDS-polyacrylamide gel electrophoresis, immunoblotting or silver staining and quantitative gel scanning...
  71. Targeted Ceramic Nanovectors for Simultaneous Therapy and Imaging of Cancer
    SANDWIP DEY; Fiscal Year: 2009
    ..The core will consist of fluorescent semiconductor quantum dots and silver nanorods for fluorescent and near-infra red (NIR) imaging, respectively...
  72. ELECTRICALLY MODULATED SKIN DELIVERY OF BETA-BLOCKERS
    Ajay Banga; Fiscal Year: 2000
    ..Beta-blockers will be delivered under anode using silver/silver chloride electrodes and analyzed by stereoselective HPLC assay...
  73. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2010
    ..metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver. Soft metals have highly distinct chemistry, which gives rise to unique challenges faced by soft metal ..
  74. Anti-Infective Central Venous Catheter
    MICHAEL VIOLANTE; Fiscal Year: 2002
    ..Another coated device on the market, using an active agent combination of silver sulfadiazine and chlorhexidine, has shown limited efficacy in clinical studies and was associated with ..
  75. PHOSPHORIMAGER
    Allan Brasier; Fiscal Year: 1993
    ..and relies on, and is limited by, the physics of energy transfer between incident radioactive particles and silver halide crystals embedded in a film emulsion...
  76. EVALUATION OF MERCURY RELEASE FROM DENTAL AMALGAMS
    Toru Okabe; Fiscal Year: 2003
    ..A series of alloys will be prepared to test specific hypotheses about the effect of palladium (Pd) additions, silver (Ag) and tin (Sn) ratio, and copper (Cu) content...
  77. SUBCELLULAR EFFECTS OF METABOLIC HORMONES ON RAT LIVER
    ROBERT CARDELL; Fiscal Year: 1991
    ..synthesized glycogen to smooth endoplasmic reticulum (SER) and other organelles by identifying the location of silver grains in light and electron microscopy autoradiographs after a pulse label of 3H-galactose...
  78. Topical negative pressure dressings for the prevention of chronic wound biofilm
    GUY ORGAMBIDE; Fiscal Year: 2009
    ..Technologies like antimicrobial silver, topical growth factors and ultrasound have all contributed to the current state of care...
  79. DISSOLUTION OF MERCURY FROM DENTAL AMALGAMS
    Miroslav Marek; Fiscal Year: 2001
    ..In this project period the research is focused on the role of the oxide on the surface of the silver-mercury (gamma1) matrix phase of dental amalgam, which is the main source of released mercury, as a barrier to ..
  80. LOCALIZATION OF PROCOLLAGENS IN DENTAL TISSUES
    CHARLES LEBLOND; Fiscal Year: 1990
    ..Thus, at various times after in injection of 3H-proline, radioautographic silver grains (which are spherical and about 50 nm wide) and immunogold particles (15 nm) can be counted separately over ..
  81. DENTAL AMALGAMS AND NEUROPSYCHOLOGICAL FUNCTION
    Pam Factor Litvak; Fiscal Year: 1999
    DESCRIPTION: There is considerable evidence that some mercury from "silver fillings" distributes to body tissues, particularly the brain...