manganese

Summary

Summary: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)

Top Publications

  1. pmc Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens
    Steven M Damo
    Department of Biochemistry, and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232 8725, USA
    Proc Natl Acad Sci U S A 110:3841-6. 2013
  2. ncbi Metal chelation and inhibition of bacterial growth in tissue abscesses
    Brian D Corbin
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 319:962-5. 2008
  3. pmc Nutritional immunity beyond iron: a role for manganese and zinc
    Thomas E Kehl-Fie
    Vanderbilt University Medical Center, Department of Microbiology and Immunology, USA
    Curr Opin Chem Biol 14:218-24. 2010
  4. pmc Role of manganese in neurodegenerative diseases
    Aaron B Bowman
    Department of Neurology, Vanderbilt Kennedy Center, Center for Molecular Toxicology, Vanderbilt University Medical Center, Nashville, TN 37232 8552, United States
    J Trace Elem Med Biol 25:191-203. 2011
  5. pmc A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and Neisseria meningitidis virulence
    Frédéric J Veyrier
    Institut Pasteur, Infection Bactériennes Invasives, Dept Infection et Epidémiologie, Paris, France
    PLoS Pathog 7:e1002261. 2011
  6. pmc Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
    Aaron D Gitler
    Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute, Cambridge, Massachusetts 02142, USA
    Nat Genet 41:308-15. 2009
  7. ncbi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
  8. pmc Nramp5 is a major transporter responsible for manganese and cadmium uptake in rice
    Akimasa Sasaki
    Institute of Plant Science and Resources, Okayama University, Kurashiki, Japan
    Plant Cell 24:2155-67. 2012
  9. pmc Manganese and Parkinson's disease: a critical review and new findings
    Tomas R Guilarte
    Neurotoxicology and Molecular Imaging Laboratory, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 118:1071-80. 2010
  10. pmc The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis
    Lauren S Waters
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    J Bacteriol 193:5887-97. 2011

Detail Information

Publications392 found, 100 shown here

  1. pmc Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens
    Steven M Damo
    Department of Biochemistry, and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232 8725, USA
    Proc Natl Acad Sci U S A 110:3841-6. 2013
    ....
  2. ncbi Metal chelation and inhibition of bacterial growth in tissue abscesses
    Brian D Corbin
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 319:962-5. 2008
    ..These results demonstrate that calprotectin is a critical factor in the innate immune response to infection and define metal chelation as a strategy for inhibiting microbial growth inside abscessed tissue...
  3. pmc Nutritional immunity beyond iron: a role for manganese and zinc
    Thomas E Kehl-Fie
    Vanderbilt University Medical Center, Department of Microbiology and Immunology, USA
    Curr Opin Chem Biol 14:218-24. 2010
    ..Recent work has demonstrated that in addition to iron, vertebrates sequester zinc and manganese both intracellularly and extracellularly to protect against infection...
  4. pmc Role of manganese in neurodegenerative diseases
    Aaron B Bowman
    Department of Neurology, Vanderbilt Kennedy Center, Center for Molecular Toxicology, Vanderbilt University Medical Center, Nashville, TN 37232 8552, United States
    J Trace Elem Med Biol 25:191-203. 2011
    b>Manganese (Mn) is an essential ubiquitous trace element that is required for normal growth, development and cellular homeostasis...
  5. pmc A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and Neisseria meningitidis virulence
    Frédéric J Veyrier
    Institut Pasteur, Infection Bactériennes Invasives, Dept Infection et Epidémiologie, Paris, France
    PLoS Pathog 7:e1002261. 2011
    ..fully understood, previous studies (including our own data) have reported that, unlike Ng, Nm tolerates high manganese concentrations...
  6. pmc Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
    Aaron D Gitler
    Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute, Cambridge, Massachusetts 02142, USA
    Nat Genet 41:308-15. 2009
    ..These data provide a direct functional connection between alpha-syn and another PD susceptibility locus. Manganese exposure is an environmental risk factor linked to PD and PD-like syndromes...
  7. ncbi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
    ..common metal of the second type is iron, which is prevalent in the catalysis of redox reactions, followed by manganese, cobalt, molybdenum, copper and nickel...
  8. pmc Nramp5 is a major transporter responsible for manganese and cadmium uptake in rice
    Akimasa Sasaki
    Institute of Plant Science and Resources, Okayama University, Kurashiki, Japan
    Plant Cell 24:2155-67. 2012
    ..Taken together, Nramp5 is a major transporter of Mn and Cd and is responsible for the transport of Mn and Cd from the external solution to root cells...
  9. pmc Manganese and Parkinson's disease: a critical review and new findings
    Tomas R Guilarte
    Neurotoxicology and Molecular Imaging Laboratory, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 118:1071-80. 2010
    Excess accumulation of manganese (Mn) in the brain results in a neurological syndrome with cognitive, psychiatric, and movement abnormalities...
  10. pmc The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis
    Lauren S Waters
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    J Bacteriol 193:5887-97. 2011
    b>Manganese is a critical micronutrient for cells, serving as an enzyme cofactor and protecting against oxidative stress. Yet, manganese is toxic in excess and little is known about its distribution in cells...
  11. pmc Manganese exposure from drinking water and children's academic achievement
    Khalid Khan
    Columbia University Mailman School of Public Health, Department of Environmental Health Sciences, United States
    Neurotoxicology 33:91-7. 2012
    Drinking water manganese (WMn) is a potential threat to children's health due to its associations with a wide range of outcomes including cognitive, behavioral and neuropsychological effects...
  12. pmc OsYSL6 is involved in the detoxification of excess manganese in rice
    Akimasa Sasaki
    Institute of Plant Science and Resources, Okayama University, Kurashiki 710 0046, Japan
    Plant Physiol 157:1832-40. 2011
    ..Knockout of OsYSL6 resulted in decreased growth of both roots and shoots only in the high-manganese (Mn) condition...
  13. ncbi Accumulation of Mn(II) in Deinococcus radiodurans facilitates gamma-radiation resistance
    M J Daly
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Science 306:1025-8. 2004
    ..We show that D. radiodurans accumulates very high intracellular manganese and low iron levels compared with radiation-sensitive bacteria and that resistance exhibits a concentration-..
  14. pmc Manganese transporters Yfe and MntH are Fur-regulated and important for the virulence of Yersinia pestis
    Robert D Perry
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    Microbiology 158:804-15. 2012
    ..Bubonic and pneumonic plague are quite different diseases that result from different routes of infection. Manganese (Mn) acquisition is critical for the growth and pathogenesis of a number of bacteria...
  15. pmc Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus
    Thomas E Kehl-Fie
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell Host Microbe 10:158-64. 2011
    By sequestering manganese and zinc, the neutrophil protein calprotectin plays a crucial role in host defense against bacterial and fungal pathogens. However, the essential processes disrupted by calprotectin remain unknown...
  16. ncbi Rice metal-nicotianamine transporter, OsYSL2, is required for the long-distance transport of iron and manganese
    Yasuhiro Ishimaru
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Plant J 62:379-90. 2010
    ..We previously isolated OsYSL2, a functional iron [Fe(II)]- and manganese [Mn(II)]-nicotianamine complex transporter that is expressed in phloem cells and developing seeds...
  17. pmc Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane
    N Jabado
    Department of Biochemistry, McGill University, Montreal H3G 1Y6, Quebec, Canada
    J Exp Med 192:1237-48. 2000
    ..Such cations are likely essential for microbial function and their removal from the phagosomal microenvironment impairs pathogenesis, resulting in enhanced bacteriostasis or bactericidal activity...
  18. ncbi Nutritional aspects of manganese homeostasis
    Judy L Aschner
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Aspects Med 26:353-62. 2005
    b>Manganese (Mn) is an essential mineral. It is present in virtually all diets at low concentrations...
  19. pmc Manganese exposure and cognitive deficits: a growing concern for manganese neurotoxicity
    H A Roels
    Louvain Centre for Toxicology and applied Pharmacology, Universite Catholique de Louvain Brussels, Avenue Mounier 53 02, B 1200, Belgium
    Neurotoxicology 33:872-80. 2012
    ....
  20. pmc Battles with iron: manganese in oxidative stress protection
    J Dafhne Aguirre
    Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 287:13541-8. 2012
    The redox-active metal manganese plays a key role in cellular adaptation to oxidative stress...
  21. ncbi Manganese-induced parkinsonism and Parkinson's disease
    C W Olanow
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1012:209-23. 2004
    It has long been appreciated that manganese exposure can cause neurotoxicity and a neurologic syndrome that resembles Parkinson's disease (PD)...
  22. pmc In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese
    Ulrike Dydak
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Environ Health Perspect 119:219-24. 2011
    Exposure to excessive levels of manganese (Mn) is known to induce psychiatric and motor disorders, including parkinsonian symptoms. Therefore, finding a reliable means for early detection of Mn neurotoxicity is desirable.
  23. ncbi Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity
    H J Tseng
    Department of Microbiology and Parasitology, The University of Queensland, Brisbane, QLD 4072, Australia
    Mol Microbiol 40:1175-86. 2001
    ..Taken together, these data show that N. gonorrhoeae possesses a Mn(II) uptake system that is critical for resistance to oxidative stress...
  24. ncbi Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles
    Jianyong Wang
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079 9502, USA
    Neurotoxicology 30:926-33. 2009
    ..This study was conducted to investigate the potential neurotoxicity of manganese (Mn), silver (Ag), and copper (Cu) nanoparticles using the dopaminergic neuronal cell line, PC12...
  25. ncbi MicroRNA expression profile in common bean (Phaseolus vulgaris) under nutrient deficiency stresses and manganese toxicity
    Oswaldo Valdés-López
    Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico, Cuernavaca, Mexico
    New Phytol 187:805-18. 2010
    ..roots and nodules of control and nutrient-stressed (phosphorus, nitrogen, or iron deficiency; acidic pH; and manganese toxicity) common bean plants...
  26. pmc Manganese toxicity upon overexposure
    Janelle Crossgrove
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    NMR Biomed 17:544-53. 2004
    b>Manganese (Mn) is a required element and a metabolic byproduct of the contrast agent mangafodipir trisodium (MnDPDP)...
  27. pmc MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese
    Thomas E Kehl-Fie
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Infect Immun 81:3395-405. 2013
    During infection, vertebrates limit access to manganese and zinc, starving invading pathogens, such as Staphylococcus aureus, of these essential metals in a process termed "nutritional immunity...
  28. ncbi Protein-folding location can regulate manganese-binding versus copper- or zinc-binding
    Steve Tottey
    Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle NE2 4HH, UK
    Nature 455:1138-42. 2008
    ..They explain why the cytoplasm must contain only tightly bound and buffered copper and Zn(2+)...
  29. pmc Manganese-induced trafficking and turnover of the cis-Golgi glycoprotein GPP130
    Somshuvra Mukhopadhyay
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Mol Biol Cell 21:1282-92. 2010
    b>Manganese is an essential element that is also neurotoxic at elevated exposure. However, mechanisms regulating Mn homeostasis in mammalian cells are largely unknown...
  30. pmc Associations of early childhood manganese and lead coexposure with neurodevelopment
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA
    Environ Health Perspect 120:126-31. 2012
    ..Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals...
  31. ncbi Nramp1 phagocyte intracellular metal withdrawal defense
    Mathieu F Cellier
    INRS Institut Armand Frappier, 531, Bd des prairies, Laval, Quebec H7V 1B7, Canada
    Microbes Infect 9:1662-70. 2007
    ..Nramp1 restricts microbial access to essential micro-nutrients such as iron and manganese within professional phagosomes...
  32. ncbi Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations
    Afonso C Silva
    Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, Bethesda, MD 20892 1065, USA
    NMR Biomed 17:532-43. 2004
    b>Manganese-enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T1 contrast that is sensitive to a number of biological processes...
  33. ncbi Oxalate decarboxylase requires manganese and dioxygen for activity. Overexpression and characterization of Bacillus subtilis YvrK and YoaN
    A Tanner
    Biological Chemistry Department, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom
    J Biol Chem 276:43627-34. 2001
    ..YoaN were found to be soluble enzymes with oxalate decarboxylase activity only when expressed in the presence of manganese salts...
  34. pmc Role of the node in controlling traffic of cadmium, zinc, and manganese in rice
    Noriko Yamaguchi
    National Institute for Agro Environmental Sciences, Tsukuba, 305 8604, Japan
    J Exp Bot 63:2729-37. 2012
    ..To find a mechanism for restricting cadmium (Cd) transport into grains, the distribution of Cd, zinc (Zn), manganese (Mn), and sulphur (S) around the vascular bundles in node I (the node beneath the panicle) of Oryza sativa '..
  35. pmc World Health Organization discontinues its drinking-water guideline for manganese
    Seth H Frisbie
    Department of Chemistry and Biochemistry, Norwich University, Northfield, Vermont, USA
    Environ Health Perspect 120:775-8. 2012
    ..In this edition, the 400-µg/L drinking-water guideline for manganese (Mn) was discontinued with the assertion that because "this health-based value is well above concentrations of ..
  36. pmc Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR
    Cheryl Lynn Y Ong
    School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia
    Infect Immun 81:421-9. 2013
    ..In this study, we investigated the effect of iron and manganese ion availability on the growth of a ritR mutant...
  37. pmc Ribonucleotides and manganese ions improve non-homologous end joining by human Polμ
    María José Martín
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, 28049 Madrid, Spain
    Nucleic Acids Res 41:2428-36. 2013
    ....
  38. pmc Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis
    Katja M Kanninen
    Department of Pathology, The University of Melbourne, Victoria, Australia
    PLoS ONE 8:e58644. 2013
    ..Analyses revealed increased zinc and manganese concentrations in affected sheep brain in those regions where neuroinflammation and neurodegeneration first ..
  39. pmc Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase
    M Fahad Khalid
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Nucleic Acids Res 33:6349-60. 2005
    ..Dbr1 sediments as a monomer and requires manganese as the metal cofactor for debranching.
  40. pmc Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh
    Gail A Wasserman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 115:285-9. 2007
    ..We recently reported results of a cross-sectional investigation of intellectual function in 10-year-olds in Bangladesh, who had been exposed to arsenic from drinking water in their home wells...
  41. ncbi Manganese dosimetry: species differences and implications for neurotoxicity
    Michael Aschner
    Vanderbilt University, Nashville, Tennessee, USA
    Crit Rev Toxicol 35:1-32. 2005
    b>Manganese (Mn) is an essential mineral that is found at low levels in food, water, and the air. Under certain high-dose exposure conditions, elevations in tissue manganese levels can occur...
  42. pmc Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes
    Eun Sook Y Lee
    Department of Neurology, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Neurochem 110:530-44. 2009
    Chronic exposure to manganese (Mn) can cause manganism, a neurodegenerative disorder similar to Parkinson's disease. The toxicity of Mn includes impairment of astrocytic glutamate transporters...
  43. pmc Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 protein
    Jieqiong Tan
    State Key Laboratory of Medical Genetics, Xiangya Medical School, Central South University, Changsha, Hunan, China
    J Biol Chem 286:29654-62. 2011
    ..In addition, wild-type ATP13A2 reduced intracellular manganese concentrations and prevented cytochrome c release from mitochondria compared with the pathogenic mutants...
  44. pmc Intellectual impairment in school-age children exposed to manganese from drinking water
    Maryse F Bouchard
    Centre for Interdisciplinary Studies in Biology, Health, Society and Environment, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Environ Health Perspect 119:138-43. 2011
    b>Manganese is an essential nutrient, but in excess it can be a potent neurotoxicant. Despite the common occurrence of manganese in groundwater, the risks associated with this source of exposure are largely unknown.
  45. pmc Same-session functional assessment of rat retina and brain with manganese-enhanced MRI
    David Bissig
    Department of Anatomy and Cell Biology, Wayne State University, Detroit, MI 48201, USA
    Neuroimage 58:749-60. 2011
    b>Manganese-enhanced MRI (MEMRI) is a powerful non-invasive approach for objectively measuring either retina or binocular visual brain activity in vivo...
  46. pmc Maternal blood manganese levels and infant birth weight
    Ami R Zota
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 20:367-73. 2009
    b>Manganese is both an essential element and a known neurotoxicant to children...
  47. pmc Intellectual function in Mexican children living in a mining area and environmentally exposed to manganese
    Horacio Riojas-Rodriguez
    Dirección de Salud Ambiental, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Environ Health Perspect 118:1465-70. 2010
    Excessive exposure to manganese (Mn), an essential trace element, has been shown to be neurotoxic, especially when inhaled. Few studies have examined potential effects of Mn on cognitive functions of environmentally exposed children.
  48. pmc Early postnatal blood manganese levels and children's neurodevelopment
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:433-9. 2010
    Recent evidence suggests that low-level environmental exposure to manganese adversely affects child growth and neurodevelopment...
  49. ncbi A role for the AtMTP11 gene of Arabidopsis in manganese transport and tolerance
    Emmanuel Delhaize
    CSIRO Plant Industry, Canberra, ACT, Australia
    Plant J 51:198-210. 2007
    ..These findings provide evidence for Mn(2+)-specific transport activity by AtMTP11, and implicate the pre-vacuolar compartments in both Mn(2+) tolerance and Mn(2+) homeostasis mechanisms of Arabidopsis...
  50. ncbi Brain energy metabolism in a sub-acute rat model of manganese neurotoxicity: an ex vivo nuclear magnetic resonance study using [1-13C]glucose
    Claudia Zwingmann
    Department of Organic Chemistry, University of Bremen, Bremen, Germany
    Neurotoxicology 25:573-87. 2004
    ..vivo injection of [1-13C]glucose was applied to gain insight into the mechanism(s) leading to energy failure in manganese neurotoxicity. In rats treated for 4 days with 50mg/kg MnCl(2) (intraperitoneally, i.p...
  51. ncbi Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues
    L A MacMillan-Crow
    Department of Surgery, University of Alabama at Birmingham 35294, USA
    Biochemistry 37:1613-22. 1998
    Previous studies from our laboratory have demonstrated that the mitochondrial protein manganese superoxide dismutase is inactivated, tyrosine nitrated, and present as higher molecular mass species during human renal allograft rejection...
  52. pmc Genes encoding proteins of the cation diffusion facilitator family that confer manganese tolerance
    Emmanuel Delhaize
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Canberra ACT 2601, Australia
    Plant Cell 15:1131-42. 2003
    ..We suggest that the ShMTP1 proteins are members of the CDF family involved in conferring Mn(2+) tolerance and that at least one of these proteins (ShMTP1) confers tolerance by sequestering Mn(2+) into internal organelles...
  53. pmc ECA3, a Golgi-localized P2A-type ATPase, plays a crucial role in manganese nutrition in Arabidopsis
    Rebecca F Mills
    School of Biological Sciences, University of Southampton, Southampton, UK
    Plant Physiol 146:116-28. 2008
    Calcium (Ca) and manganese (Mn) are essential nutrients required for normal plant growth and development, and transport processes play a key role in regulating their cellular levels...
  54. pmc Expression of arabidopsis CAX2 in tobacco. Altered metal accumulation and increased manganese tolerance
    K D Hirschi
    Baylor College of Medicine, Plant Physiology Group, United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Houston, Texas 77030, USA
    Plant Physiol 124:125-33. 2000
    ..These results suggest that CAX2 has a broad substrate range and modulation of this transporter may be an important component of future strategies to improve plant ion tolerance...
  55. pmc Export of vacuolar manganese by AtNRAMP3 and AtNRAMP4 is required for optimal photosynthesis and growth under manganese deficiency
    Viviane Lanquar
    Institut des Sciences du Vegetal, CNRS, 91198 Gif sur Yvette, France
    Plant Physiol 152:1986-99. 2010
    b>Manganese (Mn) is an essential element, acting as cofactor in numerous enzymes. In particular, a Mn cluster is indispensable for the function of the oxygen-evolving complex of photosystem II...
  56. pmc Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli
    Adil Anjem
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Mol Microbiol 72:844-58. 2009
    Very little manganese is imported into Escherichia coli under routine growth conditions: the import system is weakly expressed, the manganese content is low, and a manganese-dependent enzyme is not correctly metallated...
  57. pmc Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents
    Peter Caravan
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 149 Thirteenth St, Charlestown, MA 02129, USA
    Contrast Media Mol Imaging 4:89-100. 2009
    ..The field-dependent relaxivities of a panel of gadolinium and manganese complexes with different molecular parameters, water exchange rates, rotational correlation times, hydration ..
  58. ncbi Manganese- and iron-dependent marine methane oxidation
    Emily J Beal
    Department of Geosciences and Penn State Astrobiology Research Center, Pennsylvania State University, University Park, PA 16802, USA
    Science 325:184-7. 2009
    ..that microorganisms from marine methane-seep sediment in the Eel River Basin in California are capable of using manganese (birnessite) and iron (ferrihydrite) to oxidize methane, revealing that marine AOM is coupled, either directly ..
  59. ncbi Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane
    John R Forbes
    Department of Biochemistry, McGill University, 3655 Sir William Osler Promenade, Montreal, QC, Canada, H3G1Y6
    Blood 102:1884-92. 2003
    ..These results clarify the mechanism by which Nramp1 contributes to phagocyte defenses against infections...
  60. pmc Interplay between manganese and zinc homeostasis in the human pathogen Streptococcus pneumoniae
    Faith E Jacobsen
    Department of Chemistry, Indiana University, Bloomington, IN 47405 7102, USA
    Metallomics 3:38-41. 2011
    ..We conclude that Zn(II) toxicity results in a cytoplasmic Mn(II) deficiency, possibly caused by competition at the Mn(II) uptake transporter protein PsaA...
  61. pmc Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man
    Karin Tuschl
    Clinical and Molecular Genetics Unit, University College London Institute of Child Health, UK
    Am J Hum Genet 90:457-66. 2012
    Environmental manganese (Mn) toxicity causes an extrapyramidal, parkinsonian-type movement disorder with characteristic magnetic resonance images of Mn accumulation in the basal ganglia...
  62. ncbi A mechanism for initiating RNA-dependent RNA polymerization
    S J Butcher
    Institute of Biotechnology and Department of Biosciences, Viikki Biocenter, PO Box 56 (Viikinkaari 5, 00014 University of Helsinki, Finland
    Nature 410:235-40. 2001
    ..Our results provide a working model for the initiation of replication and transcription...
  63. ncbi Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga toxicosis
    Somshuvra Mukhopadhyay
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Science 335:332-5. 2012
    ..We found that the widely available metal manganese (Mn(2+)) blocked endosome-to-Golgi trafficking of STx and caused its degradation in lysosomes...
  64. pmc Arsenic and manganese exposure and children's intellectual function
    Gail A Wasserman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York City, NY 10032, USA
    Neurotoxicology 32:450-7. 2011
    ..demonstrated independent associations between neurobehavioral function and exposure to both arsenic (As) and manganese (Mn) in school-aged children...
  65. pmc Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release
    Marcin Nowotny
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 25:1924-33. 2006
    ..Lastly, product release probably requires dissociation of metal ion A, which is inhibited by either high concentrations of divalent cations or mutation of an assisting protein residue...
  66. pmc Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
    Cong Zhao
    Laboratory of Structural Biology, Room 201, New Life Sciences Building, Tsinghua University, Beijing 100084, China
    J Virol 83:9024-30. 2009
    ..The identification of this binding pocket opens a new avenue for anti-influenza drug discovery, targeting the cap-dependent endonuclease, in response to the worldwide threat of influenza...
  67. ncbi Co-exposure to environmental lead and manganese affects the intelligence of school-aged children
    Yeni Kim
    Division of Child and Adolescent Psychiatry, Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, 28 YeonGun Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Neurotoxicology 30:564-71. 2009
    Exposure to environmental levels of lead (Pb) and manganese (Mn) has been associated with detrimental effects to neurodevelopment...
  68. pmc Initial steps of photosystem II de novo assembly and preloading with manganese take place in biogenesis centers in Synechocystis
    Anna Stengel
    Molekulare Pflanzenwissenschaften, Biozentrum Ludwig Maximilians Universität München, 82152 Planegg Martinsried, Germany
    Plant Cell 24:660-75. 2012
    ..We propose an extended model for the spatial organization of Mn(2+) transport to PSII, which is suggested to take place concomitantly with early steps of PSII assembly in biogenesis centers at the cell periphery...
  69. pmc Pathophysiology of manganese-associated neurotoxicity
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63131, USA
    Neurotoxicology 33:881-6. 2012
    b>Manganese (Mn) is a well established neurotoxin associated with specific damage to the basal ganglia in humans...
  70. ncbi Neurologic manifestations in welders with pallidal MRI T1 hyperintensity
    K A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 64:2033-9. 2005
    Neurologic symptoms have been attributed to manganese fumes generated during welding. Increased T1 MRI signal in the basal ganglia is a biologic marker of manganese accumulation...
  71. ncbi Identifying the structure of the active sites of human recombinant prolidase
    Roberta Besio
    Dipartimento di Biochimica, Sezione Medicina e Farmacia, Universita di Pavia, Pavia, Italy
    Eur Biophys J 39:935-45. 2010
    ..In both dinuclear units a histidine residue is bound to a Zn ion...
  72. ncbi Three-dimensional structure and biophysical characterization of Staphylococcus aureus cell surface antigen-manganese transporter MntC
    Alexey Gribenko
    Pfizer Vaccine Research, 401 North Middletown Road, Pearl River, NY 10965, USA
    J Mol Biol 425:3429-45. 2013
    ..Therefore, it is unlikely that antibody binding to this antigen will be affected by the occupancy of the metal-binding site by Mn²⁺...
  73. pmc A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi
    J Dafhne Aguirre
    Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 288:8468-78. 2013
    ..burgdorferi has the capacity to accumulate remarkably high levels of manganese. This high manganese is necessary to activate the SodA superoxide dismutase (SOD) essential for virulence...
  74. pmc Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury
    Marcelo Farina
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, 88040 900 Florianopolis, SC, Brazil
    Neurochem Int 62:575-94. 2013
    ..Among the 23 elements that have known physiological functions in humans, 12 are metals, including iron (Fe) and manganese (Mn)...
  75. pmc Transformation of industrial dyes by manganese peroxidases from Bjerkandera adusta and Pleurotus eryngii in a manganese-independent reaction
    A Heinfling
    FG Microbial Ecology, Technical University of Berlin, D 10587 Berlin, Germany
    Appl Environ Microbiol 64:2788-93. 1998
    ..The dyes were not oxidized or were oxidized very little by Phanerochaete chrysosporium manganese peroxidase (MnP) or by a chemically generated Mn3+-lactate complex. Lignin peroxidase (LiP) from B...
  76. pmc The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast
    Alessandra Chesi
    Department of Genetics, Stanford University School of Medicine, Stanford University, Stanford, California, United States of America
    PLoS ONE 7:e34178. 2012
    ..Ypk9 and another Parkinson's disease (PD) protein α-synuclein in multiple model systems, and a role for Ypk9 in manganese detoxification in yeast...
  77. ncbi Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non-smoking, Norwegian women in the HUNT 2 study
    Helle Margrete Meltzer
    Division of Environmental Medicine, Department of Food Safety and Nutrition, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N 0403 Oslo, Norway
    Environ Res 110:497-504. 2010
    ..To obtain more knowledge about such associations, the divalent metal ions cadmium (Cd), manganese (Mn), cobalt (Co), copper (Cu), zinc (Zn) and lead (Pb) and parameters of Fe metabolism (serum ferritin, ..
  78. pmc Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia
    Gregg D Stanwood
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37620, USA
    J Neurochem 110:378-89. 2009
    b>Manganese is an essential nutrient, integral to proper metabolism of amino acids, proteins and lipids...
  79. ncbi Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging
    Owais B Chaudhri
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Biochem Biophys Res Commun 350:298-306. 2006
    ..Using manganese-enhanced magnetic resonance imaging, we have shown distinct patterns of neuronal activation in the hypothalamus ..
  80. ncbi Mineral factors controlling essential hypertension--a study in the Chandigarh, India population
    Satish Kumar Taneja
    Department of Zoology, Panjab University, Chandigarh, 160014, India
    Biol Trace Elem Res 120:61-73. 2007
    ..9 to 45.80% in the year 1968 and 2002). Zinc (Zn), copper (Cu), magnesium (Mg), and manganese (Mn) in the serum are considered important in maintaining the human hypertension...
  81. pmc Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets
    Dipanjan Pan
    C TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, Missouri 63108, USA
    J Am Chem Soc 130:9186-7. 2008
    ..We have developed a self-assembled, manganese(III)-labeled nanobialys (1), a toroidal-shaped MR theranostic nanoparticle...
  82. ncbi Macronutrient, mineral and trace element composition of breast milk from Japanese women
    Namiko Yamawaki
    Nutrition Research Institute, Meiji Dairies Corporation, 540 Naruda, Odawara, Kanagawa 250 0862, Japan
    J Trace Elem Med Biol 19:171-81. 2005
    ..8 mg/100 mL; potassium, 47.0+/-12.1 mg/100 mL; calcium, 25.0+/-7.1 mg/100 mL; chromium, 5.9+/-4.7 microg/100 mL; manganese, 1.1+/-2...
  83. pmc Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI
    Joseph J Gallagher
    Biological Imaging Center, Beckman Institute, m c 139 74, California Institute of Technology, Pasadena, California 91125, USA
    Neuroimage 60:1856-66. 2012
    ..b>Manganese-enhanced MRI (MEMRI) detects axonal transport dynamics in preclinical studies...
  84. ncbi Altered white matter microstructural integrity revealed by voxel-wise analysis of diffusion tensor imaging in welders with manganese exposure
    Yangho Kim
    Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea
    Neurotoxicology 32:100-9. 2011
    Chronic exposure to manganese (Mn), which can be an occupational hazard or can result from liver failure, is associated with adverse motor and cognitive outcomes...
  85. ncbi Biochemistry. Water photolysis in biology
    A W Rutherford
    Service of Bioenergetics, CNRS URA 2096, Departement de Biologie Joliot Curie, CEA Saclay, 91191 Gif sur Yvette, France
    Science 303:1782-4. 2004
  86. ncbi Impaired apparent ion demand in experimental diabetic retinopathy: correction by lipoic Acid
    Bruce A Berkowitz
    Department of Anatomy and Cell Biology, Wayne State University, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 48:4753-8. 2007
    ..To test the hypothesis that early in the course of diabetes, apparent ion demand within the retina is impaired and may be corrected by alpha-lipoic acid (LPA), a drug that inhibits vascular histopathology...
  87. ncbi Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases
    Annemarie Wehenkel
    Unité de Biochimie Structurale and CNRS URA 2185, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Mol Biol 374:890-8. 2007
    ..The absence of metal correlates with a partially unstructured flap segment, indicating that the third manganese ion contributes to reposition the flap, but is dispensable for catalysis...
  88. pmc NrdH-redoxin protein mediates high enzyme activity in manganese-reconstituted ribonucleotide reductase from Bacillus anthracis
    Mikael Crona
    Department of Molecular Biology and Functional Genomics, Arrhenius Laboratories for Natural Sciences, Stockholm University SE 10691 Stockholm, Sweden
    J Biol Chem 286:33053-60. 2011
    ..anthracis. Whether the Fe-NrdF form only exists in vitro or whether the NrdF protein in B. anthracis is a true cambialistic enzyme that can work with either manganese or iron remains to be established.
  89. pmc Noncatalytic ions direct the RNA-dependent RNA polymerase of bacterial double-stranded RNA virus ϕ6 from de novo initiation to elongation
    Sam Wright
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Virol 86:2837-49. 2012
    ....
  90. ncbi Directed evolution of a temperature-, peroxide- and alkaline pH-tolerant versatile peroxidase
    Eva García-Ruiz
    Department of Biocatalysis, Institute of Catalysis, CSIC, Cantoblanco, 28049 Madrid, Spain
    Biochem J 441:487-98. 2012
    ..Overall, the directed evolution approach described provides a set of strategies for selecting VPs with improvements in secretion, activity and stability...
  91. ncbi Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Neurotoxicology 30:915-25. 2009
    ..regarding a possible causal association between neurological effects in welders and the presence of manganese (Mn) in welding fume...
  92. ncbi A new direction for manganese homeostasis in bacteria: identification of a novel efflux system in Streptococcus pneumoniae
    Nicholas S Jakubovics
    Oral Biology, School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK
    Mol Microbiol 72:1-4. 2009
    ..Thus, MntE represents a new lead for the development of antimicrobials specifically aimed at disrupting microbial metal ion homeostasis...
  93. ncbi Enhanced Cd2+ -selective root-tonoplast-transport in tobaccos expressing Arabidopsis cation exchangers
    V Koren'kov
    Department of Plant and Soil Sciences, Plant Biology Program, University of Kentucky, Lexington, KY 40546, USA
    Planta 225:403-11. 2007
    ..Results support a model in which certain CAX antiporters are somewhat more selective for particular divalent cations...
  94. pmc Correspondence between altered functional and structural connectivity in the contralesional sensorimotor cortex after unilateral stroke in rats: a combined resting-state functional MRI and manganese-enhanced MRI study
    Maurits P A van Meer
    Image Sciences Institute, University Medical Center Utrecht, The Netherlands
    J Cereb Blood Flow Metab 30:1707-11. 2010
    ..resting-state functional magnetic resonance imaging (MRI), and neuroanatomical connectivity, as measured with manganese-enhanced MRI, in rats at 10 weeks after unilateral stroke and in age-matched controls...
  95. ncbi Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese
    M E Andersen
    K S Crump Group, Inc, Research Triangle Park, NC 27709, USA
    Neurotoxicology 20:161-71. 1999
    b>Manganese (Mn)-deficiency or Mn-excess can lead to adverse biological consequences...
  96. ncbi Role and regulation of the superoxide dismutases of Staphylococcus aureus
    Michail H Karavolos
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Microbiology 149:2749-58. 2003
    ..Under standard growth conditions, manganese (Mn), a mineral superoxide scavenger, elevated total SOD activity but had no effect on the transcription of ..
  97. ncbi Crystal structure of manganese catalase from Lactobacillus plantarum
    V V Barynin
    The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, S10 2TN, Sheffield, United Kingdom
    Structure 9:725-38. 2001
    ..are known, one having a heme cofactor, and the other, a structurally distinct family containing nonheme manganese. We have solved the structure of the mesophilic manganese catalase from Lactobacillus plantarum and its azide-..
  98. pmc Copper and manganese induce yeast apoptosis via different pathways
    Qiuli Liang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Mol Biol Cell 18:4741-9. 2007
    ..Here, for the first time we studied two essential nutritional elements, copper and manganese, for their apoptotic effects in yeast Saccharomyces cerevisiae...
  99. pmc Bacillus subtilis polynucleotide phosphorylase 3'-to-5' DNase activity is involved in DNA repair
    Paula P Cardenas
    Department of Microbial Biotechnology, Centro Nacional de Biotecnologia, CSIC, C Darwin 3, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Nucleic Acids Res 37:4157-69. 2009
    ..Our data suggest that PNPase is involved in various nucleic acid metabolic pathways, and its limited ssDNA exonuclease activity plays an important role in RecA-dependent and RecA-independent repair pathways...
  100. ncbi A study of the relationships between Parkinson's disease and markers of traffic-derived and environmental manganese air pollution in two Canadian cities
    Murray M Finkelstein
    McMaster University and University of Toronto, Canada
    Environ Res 104:420-32. 2007
    There is concern that industrial emissions of manganese (Mn) and the use of Mn-containing compounds as fuel additives might increase the population risk of Parkinson's disease (PD)-like disorders...
  101. pmc Role of the manganese efflux system mntE for signalling and pathogenesis in Streptococcus pneumoniae
    Jason W Rosch
    Department of Infectious Diseases, St Jude s Children s Research Hospital, Memphis, TN 38105, USA
    Mol Microbiol 72:12-25. 2009
    ..The acquisition of manganese is vital for the virulence of several bacterial species...

Research Grants74

  1. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ..The involvement of the mtNOS, eNOS and iNOS isoforms, NOX enzymes and manganese superoxide dismutase in nitration and the role of hypoxia and hypoxia/reoxygenation on protein nitration and the ..
  2. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..The expression of manganese superoxide dismutase (MnSOD) is also decreased in PPHN...
  3. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..Both migrations are significantly reduced by intrapulmonary manganese superoxide dismutase-plasmid liposome (MnSOD-PL) gene therapy...
  4. Novel pathways for fat burning that protects from high fat diet-induced metabolic
    Sihem Boudina; Fiscal Year: 2013
    ..To address this, we generated mice with increased superoxide production in adipocytes through deletion of manganese superoxide dismutase (MnSOD), the sole enzyme responsible for detoxifying superoxide to hydrogen peroxide in the ..
  5. Human developmental toxicity of metal mixture exposure from e-waste recycling
    Aimin Chen; Fiscal Year: 2010
    ..E-waste contains high levels of several metals (lead [Pb], mercury [Hg], cadmium [Cd], chromium [Cr], manganese [Mn], etc...
  6. Reperfusion and Neurovascular Injury in Stroke
    Pak H Chan; Fiscal Year: 2013
    ..that signal transducer and activator of transcription 3 (STAT3) is a transcription activator of the promoter of manganese-superoxide dismutase (SOD2)...
  7. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..the neurotoxicities and dose-effect relationships associated with other heavy metals, such as arsenic (As) and manganese (Mn), are poorly understood...
  8. Investigating the pathogenesis of CoQ10 deficiencies
    Catarina M Quinzii; Fiscal Year: 2013
    ..Aim 3: To test ROS scavenging as a potential therapeutic strategy, she will overexpress the enzyme superoxide manganese dismutase (MnSOD) in COQ2 mutant fibroblasts and will assess level of ROS, oxidative stress, and apoptosis...
  9. Epidemiological Research on Autism in Jamaica - Phase II
    Mohammad H Rahbar; Fiscal Year: 2013
    ..the role of the glutathione-S-transferase (GST) genes and five heavy metals (lead, mercury, arsenic, cadmium, manganese) in relation to ASD...
  10. Bangladesh Centre for Global Environmental and Occupational Health
    Dewan Shamsul Alam; Fiscal Year: 2013
    ..millions of Bangladeshis may also be exposed to unsafe levels of other toxic metals including lead, nickel, manganese, uranium and chromium...
  11. Development of New Molecular Probes for Diagnostic Imaging of Atherosclerosis
    KAREN CATHERIN BRILEY SAEBO; Fiscal Year: 2010
    ..Since the FDA has already approved the use manganese (Mn(II)) chelates and iron oxide particles for MR liver indications, we hypothesize that oxLDL targeted Mn(II) ..
  12. Rev-ERBa Regulates Mitochondrial Biogenesis, Adiposity, and Insulin Action
    Thomas H Reynolds; Fiscal Year: 2010
    ..By treating obese mice with the manganese tetrakis benzoic acid (MnTBA) porphyrin, we have identified heme's nuclear receptor, Rev-ERBa, as a novel ..
  13. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2013
    ..Phosphorescent sensors are based on cyclometalated iridium(III) complexes. MRI constructs utilize manganese(III) porphyrins...
  14. Structure and Specificity in Metal Ion Homeostasis
    Amy C Rosenzweig; Fiscal Year: 2013
    ..Aberrant handling of metal ions such as copper, zinc, iron, and manganese is linked to numerous human diseases...
  15. Regulation of caspase-1 by Sod2 in the heart
    Kumuda C Das; Fiscal Year: 2010
    ..b>Manganese superoxide dismutase (MnSOD) is an antioxidant enzyme located in the mitochondria that provides critical ..
  16. Elucidating the A. baumannii response to calprotectin-mediated zinc starvation
    BRITTANY MORTENSEN; Fiscal Year: 2013
    ..CP also exhibits antimicrobial activity through sequestration of the essential metals zinc (Zn) and manganese (Mn). CP- mediated Zn chelation inhibits A. baumannii growth, and during A...
  17. Manganese Enhanced Multi-MRI for Murine HIV-1 Associated Neurocognitive Disorders
    Yutong Liu; Fiscal Year: 2013
    ..The objective of this proposal is to develop in-vivo manganese enhanced 3D multispectral magnetic resonance microscopy (MRM) that will serve as a biomarker for HAND...
  18. Reactive Oxygen Species Signaling in the Hippocampus
    Eric Klann; Fiscal Year: 2012
    ..In addition, these AD model mice exhibited diminished axon transport in vivo, as measured by manganese enhanced magnetic resonance imaging, long-term potentiation (LTP), and impaired hippocampus-dependent memory...
  19. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace A Spatafora; Fiscal Year: 2013
    ..to the availability and transport of essential metal ions in the plaque environment, particularly iron and manganese, metal ion uptake mechanisms represent attractive targets for drug design aimed at combating cavities...
  20. The Role of PcpA in the Mechanism of Virulence and Protective Immunity.
    MELISSA MARIE WALKER; Fiscal Year: 2013
    ..PspA in most strains is regulated through the relative concentrations of both zinc and manganese with the result that it is expressed in invasive disease in the lung, blood and organs;but is not expressed ..
  21. Role of Parkin in Regulating Manganese Toxicity
    JEROME ALLAN ROTH; Fiscal Year: 2010
    ..modeling to examine a genetic mutation which may be responsible for increasing susceptibility to develop manganese (Mn) toxicity...
  22. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace Spatafora; Fiscal Year: 2009
    ..to the availability and transport of essential metal ions in the plaque environment, particularly iron and manganese, metal ion uptake mechanisms represent attractive targets for drug design aimed at combating cavities...
  23. Mechanism of Type I and II Caused Diabetic Bladder Dysfunction
    Firouz Daneshgari; Fiscal Year: 2013
    ..sensory function of the bladder, and transgenic mice with conditional, smooth muscle-selective deletion of the manganese superoxide dismutase (MnSOD) gene], we will test our hypotheses in two Specific Aims: SA#1- To distinguish the ..
  24. Rel B mediated-redox regulation of radiation therapy
    William H St Clair; Fiscal Year: 2013
    ..that: 1) aggressive prostate cancers have high nuclear RelB, a member of the alternative pathway of NF-:B and manganese superoxide dismutase (MnSOD), a critical antioxidant enzyme levels;2) suppression of RelB in androgen ..
  25. Occupational exposure to manganese and noise potentiate hearing loss
    Richard J Salvi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Manganese (Mn) toxicity is characterized by a collection of neurological symptoms similar to the extrapyramidal dysfunction associated with Parkinson's disease...
  26. Mitochondria, Superoxide &MnSOD in a fetal hypoxic cerebral palsy model
    Matthew Derrick; Fiscal Year: 2012
    ..One of the primary enzymes that removes superoxide one of the major sources of oxidative stress, is manganese superoxide dismutase which is found in the mitochondria The hypothesis is the level of mitochondrial dysfunction ..
  27. Live imaging of brain circuitry in mouse models of PTSD
    Elaine L Bearer; Fiscal Year: 2013
    ..We will measure the neural activity and circuitry changes before and after fear with time-lapse, quantitative manganese-enhanced MRI of living mice at 11...
  28. Redox Control of Apoptosis Signaling
    MARGARET BRIEHL; Fiscal Year: 2009
    ..3) To use immunohistochemistry and PCR-based assays to test whether decreased expression of manganese superoxide dismutase occurs in different types of lymphoma and is associated with polymorphisms that alter the ..
  29. Effect of Manganese Exposure on GABA and Glutamate in Human Brains by MRS
    Ulrike Dydak; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): While manganese (Mn) is an essential trace metal, excess exposure due to occupational settings can cause damage to the nervous system...
  30. Interleukin-6 and Retinal Ganglion Cell Degeneration in Glaucoma
    Rebecca M Sappington; Fiscal Year: 2013
    ..quantify anterograde and retrograde axonal transport using active-uptake tracers and ionic activity using and manganese-enhanced magnetic resonance imaging...
  31. Role of Mechanisms of Efflux in Manganese Homeostasis and Detoxification
    Somshuvra Mukhopadhyay; Fiscal Year: 2013
    ..Thus, the K99/R00 award will act directly aid my transition from post-doctoral trainee to junior faculty. ..
  32. Neuroimaging for Early Diagnosis of Manganese Toxicity in Humans and Rodents
    Ulrike Dydak; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Excess exposure to manganese (Mn) due to occupational settings can cause damage to the nervous system...
  33. PKM2 inhibition and redox regulation in chemoprevention
    Yunfeng Zhao; Fiscal Year: 2013
    ..the JB6 mouse skin epidermal cell line, promotable JB6 (P+) and non-promotable (P-) cells with varying levels of manganese superoxide dismutase (MnSOD) expression, to determine a relationship between oxidative stress and PKM2 ..
  34. Field-Deployable Monitor to Assess Personal Exposure to Multiple Heavy Metals
    BADAWI M DWEIK; Fiscal Year: 2010
    ..a portable, self-contained, easy-to-use monitor for simultaneous on-site measurement of arsenic, cadmium, manganese and lead metals from a single urine sample, in near real time, to assess personal exposure...
  35. Influence of HFE on metal pharmacokinetics and neurotoxicity
    Jonghan Kim; Fiscal Year: 2013
    ..the training and results obtained during the mentored phase, the hypothesis that HFE-deficiency enhances manganese neurotoxicity will be tested...
  36. Biochemical Studies of Oxalate Decarboxylase
    NIGEL GORDON RICHARDS; Fiscal Year: 2013
    ..Moreover, the manganese-dependent chemical mechanism employed by the enzyme has little precedent in known chemistry, and so its ..
  37. Role of Prion Protein in Manganese Neurotoxicity
    ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2013
    ..proteins are metal binding proteins that can efficiently bind to certain divalent cations including copper and manganese at the octapeptide repeat regions of the protein...
  38. Using Transport to Map the Brain
    Elaine L Bearer; Fiscal Year: 2010
    ..e. circuitry, over an animal's lifetime can now be studied with manganese-enhance MRI (MEMRI)...
  39. Preclinical Efficacy And Safety Evaluation Of Graphene Nanoparticle-based Magneti
    Balaji Sitharaman; Fiscal Year: 2013
    ..inserted and trapped in the voids between two graphene sheets), and coordinated with graphene trace amounts of manganese (0...
  40. Features of chronic tinnitus in an animal model as indicated by MEMRI and MRS
    BORIS M ODINTSOV; Fiscal Year: 2012
    ..The proposed experiments will test these hypotheses by combining a functional imaging technique, manganese enhanced magnetic resonance imaging (MEMRI), with volume-localized proton magnetic resonance spectroscopy (1H-..
  41. Mechanisms of Manganese Neurotoxicity
    ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic exposure to high concentrations of manganese (Mn) results in adverse neurological health effects commonly referred to as manganism...
  42. Phenotypic characterization of nitric oxide regulation of cardiac function by MRI
    Xin Yu; Fiscal Year: 2013
    ..Therefore, the objectives of the proposed research are 1) to develop manganese-enhanced magnetic resonance imaging (MEMRI) methods for in vivo characterization of Ca2+ uptake in myocardium, ..
  43. Mitochondrial Redox Systems in Neurogenic Hypertension
    Matthew C Zimmerman; Fiscal Year: 2013
    ..via adenoviral-mediated overexpression of manganese superoxide dismutase (MnSOD), the O2...
  44. Novel up-regulators of NF-kB activity: effect on MnSOD and TBI in vitro models
    Maurizio Grimaldi; Fiscal Year: 2012
    ..Increased oxidant generation is counteracted by the activity of cellular enzymes such manganese superoxide dismutase (MnSOD)...
  45. Manganese Superoxide Dismutase and Renal Ischemia/Reperfusion
    LEE A MACMILLAN-CROW; Fiscal Year: 2013
    ..Our laboratory has demonstrated that the major antioxidant in the mitochondria, manganese superoxide dismutase (MnSOD), is inactivated during renal transplantation (human and rodent) and renal I/R...
  46. The novel family of superoxide dismutase enzymes in Candida albicans
    Valeria C Culotta; Fiscal Year: 2013
    ..growth conditions, the intracellular SOD1 protein is inactive and the yeast instead uses an unusual cytosolic manganese-SOD3 to remove superoxide...
  47. REDOX REGULATION OF TUMOR SUPPRESSION BY MNSOD
    Daret K St Clair; Fiscal Year: 2012
    The overall goal of this research is to elucidate the mechanisms by which the mitochondrial antioxidant enzyme, manganese containing superoxide dismutase (MnSOD), modulates the carcinogenesis action of tumor promoters and UV radiation...
  48. MANGANESE REDOX BIOCHEMISTRY
    James W Whittaker; Fiscal Year: 2012
    b>Manganese redox chemistry is fundamental to biological processes at molecular, cellular and environmental scales, from antioxidant defense to oxygenic photosynthesis...
  49. Epigenetic regulation of SOD2 and CFH gene expression in the aging RPE
    Zeljka Smit-McBride; Fiscal Year: 2013
    ..In this application, we propose to study the age-related epigenetic regulation of wild type alleles of manganese superoxide dismutase (SOD2) and complement factor H (CFH), two genes whose variant alleles are associated with ..
  50. Manganese-Enhanced MRI Studies of Vision Loss with Aging
    DAVID PHILIP BISSIG; Fiscal Year: 2013
    ..Ion regulation will be assessed using an innovative functional MRI method;manganese enhanced MRI (MEMRI), to non-invasively measure brain and retinal uptake of manganese ion (Mn2+) in adult rats...
  51. Role of Oxidative Stress and Protein Transporters in Glyphosate and Mancozeb Neur
    Vanessa A Fitsanakis; Fiscal Year: 2012
    ..Other data indicate that exposure to manganese (Mn) also may be linked to disease onset...
  52. RESTING STATE FUNCTIONAL CONNECTIVITY MRI IN MANGANESE EXPOSED WELDERS
    Susan Criswell; Fiscal Year: 2013
    ..The process of welding produces concentrated particulate fumes and gases including manganese. Concerns have arisen about exposure to manganese and the subsequent development of Parkinsonism and cognitive ..
  53. Regulation of mammalian iron homeostasis by iron and transferrin
    THOMAS BENEDICT BARTNIKAS; Fiscal Year: 2010
    ..expression, my current work has implicated transferrin (TF), the abundant serum metal-binding protein, and manganese (Mn), an essential TF-bound metal, in the regulation of hepcidin expression...
  54. Regulation of Tumor Cell Migration by Mitochondrial Superoxide Dismutase
    Nadine Hempel; Fiscal Year: 2010
    ..An important regulatory enzyme of Redox balance is the mitochondrially expressed manganese superoxide dismutase (Sod2), which catalyzes the conversion of superoxide anion to hydrogen peroxide (H2O2)...
  55. Neuroinflammation and developmental vulnerability to manganese toxicity
    Ronald B Tjalkens; Fiscal Year: 2013
    ..Exposure to elevated levels of the essential element manganese (Mn) causes a spectrum of neurochemical and neuropathologic changes that can culminate in irreversible neuronal ..
  56. Structure and Mechanism of Metalloregulatory Proteins
    David P Giedroc; Fiscal Year: 2013
    ..of metal homeostasis and cross-talk in the respiratory pathogen Streptococcus pneumoniae, focusing on zinc, manganese and copper, three metals whose concentrations change dramatically during the course of invasive disease...
  57. Regional Brain Manganese Accumulation and Functional Consequences in Welders
    Xuemei Huang; Fiscal Year: 2013
    ..Exposure to manganese (Mn), a well-known neurotoxicant, is widespread in the general population from gasoline additives, fossil fuel ..
  58. Gene-environment interactions between manganese exposure and Huntington disease
    Aaron B Bowman; Fiscal Year: 2012
    ..The work contained within this proposal focuses on the influence of manganese (Mn) exposure on the pathophysiology of Huntington's disease (HD)...
  59. Mitochondrial Target for Radiation Mitigation
    Joel S Greenberger; Fiscal Year: 2013
    ..Project 4 seeks to identify agents that stabilize mitochondrial manganese superoxide dismutase by preventing nitration...
  60. NEUROPATHOLOGY OF CHRONIC MANGANESE EXPOSURE
    Brad A Racette; Fiscal Year: 2010
    ..The primary goal of this grant is to compare brains of South African manganese (Mn) miners to the brains of South African gold (Au) miners to investigate the hypothesis that workers with ..
  61. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    Joan Selverstone Valentine; Fiscal Year: 2010
    ..In addition, we address the question of why the matrix enzyme manganese superoxide dismutase (MnSOD) does not fully protect the mitochondrial matrix under conditions of high superoxide ..
  62. Mitochondrial SOD & Breast Cancer Risk-Mechanism
    JAMES YAGER; Fiscal Year: 2003
    ..by applicant)The Val-9Ala polymorphism affects the secondary structure of the import sequence in mitochondrial manganese superoxide dismutase (MnSOD)...
  63. POSTTRANSCRIPTIONAL REGULATION OF ANTIOXIDANT ENZYMES
    LINDA CLERCH; Fiscal Year: 2002
    ..The experiments will test the hypothesis that catalase and manganese superoxide dismutase (MnSOD) RNA 3' and 5' untranslated regions (UTRs) and their corresponding binding proteins ..
  64. Mechanism and Treatment of Manganese Toxicity
    JEROME ALLAN ROTH; Fiscal Year: 2010
    b>Manganese (Mn) intoxication, a syndrome known as manganism, is most often associated with prolonged occupational exposure, although individuals with cirrhosis of the liver and related hepatic dysfunction display many of the behavioral ..
  65. MANGANESE (III) BASED OXIDATIVE FREE RADICAL CYCLIZATION
    BARRY SNIDER; Fiscal Year: 2000
    ....
  66. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2002
    ..g. oxidized manganese or iron) for anaerobic respiration...
  67. GLIAL ACTIVATION IN AGED MEMORY IMPAIRED RATS
    Kiminobu Sugaya; Fiscal Year: 1999
    ..proposal is related to my previous study , the levels of gene expression for b-amyloid protein precursor (APP), manganese super oxide dismutase (Mn-SOD) and glial fibrillary acidic protein (GFAP) in aged Long-Evans rats...
  68. CASE CONTROL/STUDY OF PARKINSONS DISEASE IN THE ELDERLY
    Richard Mayeux; Fiscal Year: 1999
    ..In support of an environmental cause, are the observations that MPTP and occupational manganese exposures both induce PD...
  69. 5ASA REGULATION OF MNSOD IN INTESTINAL CELLS
    John Valentine; Fiscal Year: 2002
    ..mechanism of action of 5-ASA remains unclear, however, we have found that 5-ASA induces a cytoprotective enzyme, manganese superoxide dismutase (MnSOD), at concentrations obtained in the colon of patients taking sulfasalazine orally...
  70. OXYGEN SENSING IN EUKARYOTIC CELLS
    Mark Goldberg; Fiscal Year: 2000
    ..transporters GLUT1 and GLUT3, has also been shown to be upregulated by the transition metals cobalt, nickel, and manganese. Little is known about the oxygen (02) sensing pathway(s) which mediate this regulation...
  71. SUPEROXIDE REGULATION OF FIBROSARCOMA CELL GROWTH
    JUAN MELENDEZ; Fiscal Year: 2001
    ..Preliminary studies conducted by the applicant demonstrate that manganese superoxide dismutase (MnSOD) overexpression, an enzyme which catalyzes the removal of superoxide from the ..
  72. EPIDEMIOLOGICAL RISK FACTORS FOR PARKINSONS DISEASE
    Jay Gorell; Fiscal Year: 2001
    ..The focus of that work was the assessment of occupational exposure to six metals (iron, manganese, copper, lead, mercury, and zinc) and the risk of PD...
  73. REGULATION OF THE MANGANESE SUPEROXIDE DISMUTASE GENE
    Susan Church; Fiscal Year: 1991
    ..against O2- is provided by the family of metalloenzymes called superoxide dismutases (SOD), including the manganese (Mn) SOD vhich is located predominantly in mitothondria...