iron

Summary

Summary: A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It has the atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia. (From Dorland, 27th ed)

Top Publications

  1. pmc Hepcidin and iron homeostasis
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1823:1434-43. 2012
  2. ncbi Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Science 306:2090-3. 2004
  3. doi The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism
    Roland Lill
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat Marburg, Robert Koch Str 6, 35033 Marburg, Germany
    Biochim Biophys Acta 1823:1491-508. 2012
  4. doi Two to tango: regulation of Mammalian iron metabolism
    Matthias W Hentze
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 142:24-38. 2010
  5. pmc Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    Paul B Yu
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 4:33-41. 2008
  6. doi Iron uptake, translocation, and regulation in higher plants
    Takanori Kobayashi
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan
    Annu Rev Plant Biol 63:131-52. 2012
  7. pmc Hepcidin and iron regulation, 10 years later
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Blood 117:4425-33. 2011
  8. pmc Iron in infection and immunity
    James E Cassat
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37237, USA
    Cell Host Microbe 13:509-19. 2013
  9. ncbi A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    C Pigeon
    INSERM U522, CHRU Pontchaillou, Rennes, France
    J Biol Chem 276:7811-9. 2001
  10. pmc Mechanisms of mammalian iron homeostasis
    Kostas Pantopoulos
    Lady Davis Institute for Medical Research, Jewish General Hospital and Department of Medicine, McGill University, Montreal, QC, Canada
    Biochemistry 51:5705-24. 2012

Detail Information

Publications317 found, 100 shown here

  1. pmc Hepcidin and iron homeostasis
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1823:1434-43. 2012
    Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the plasma iron concentrations in humans remain stable at 10-30 μM...
  2. ncbi Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Science 306:2090-3. 2004
    Hepcidin is a peptide hormone secreted by the liver in response to iron loading and inflammation. Decreased hepcidin leads to tissue iron overload, whereas hepcidin overproduction leads to hypoferremia and the anemia of inflammation...
  3. doi The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism
    Roland Lill
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat Marburg, Robert Koch Str 6, 35033 Marburg, Germany
    Biochim Biophys Acta 1823:1491-508. 2012
    Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron-sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter two topics and their intimate connection...
  4. doi Two to tango: regulation of Mammalian iron metabolism
    Matthias W Hentze
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 142:24-38. 2010
    Disruptions in iron homeostasis from both iron deficiency and overload account for some of the most common human diseases...
  5. pmc Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    Paul B Yu
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 4:33-41. 2008
    ..Using dorsomorphin, we examined the role of BMP signaling in iron homeostasis...
  6. doi Iron uptake, translocation, and regulation in higher plants
    Takanori Kobayashi
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan
    Annu Rev Plant Biol 63:131-52. 2012
    b>Iron is essential for the survival and proliferation of all plants...
  7. pmc Hepcidin and iron regulation, 10 years later
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Blood 117:4425-33. 2011
    Under evolutionary pressure to counter the toxicity of iron and to maintain adequate iron supply for hemoglobin synthesis and essential metabolic functions, humans and other vertebrates have effective mechanisms to conserve iron and to ..
  8. pmc Iron in infection and immunity
    James E Cassat
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37237, USA
    Cell Host Microbe 13:509-19. 2013
    b>Iron is an essential nutrient for both humans and pathogenic microbes...
  9. ncbi A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    C Pigeon
    INSERM U522, CHRU Pontchaillou, Rennes, France
    J Biol Chem 276:7811-9. 2001
    Considering that the development of hepatic lesions related to iron overload diseases might be a result of abnormally expressed hepatic genes, we searched for new genes up-regulated under the condition of iron excess...
  10. pmc Mechanisms of mammalian iron homeostasis
    Kostas Pantopoulos
    Lady Davis Institute for Medical Research, Jewish General Hospital and Department of Medicine, McGill University, Montreal, QC, Canada
    Biochemistry 51:5705-24. 2012
    b>Iron is vital for almost all organisms because of its ability to donate and accept electrons with relative ease...
  11. doi Iron sensing and signalling
    Rayko Evstatiev
    Department of Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria
    Gut 61:933-52. 2012
    b>Iron deficiency is a common condition increasingly diagnosed and treated by gastroenterologists...
  12. doi Maternal and child undernutrition: global and regional exposures and health consequences
    Robert E Black
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Lancet 371:243-60. 2008
  13. ncbi A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    A T McKie
    Department of Molecular Medicine, King s College London, Guy s, King s, St Thomas School of Medicine, United Kingdom
    Mol Cell 5:299-309. 2000
    b>Iron absorption by the duodenal mucosa is initiated by uptake of ferrous Fe(II) iron across the brush border membrane and culminates in transfer of the metal across the basolateral membrane to the portal vein circulation by an unknown ..
  14. pmc Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
    James A Duce
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria 3052, Australia
    Cell 142:857-67. 2010
    ..Ablation of APP in HEK293T cells and primary neurons induces marked iron retention, whereas increasing APP695 promotes iron export...
  15. pmc Nutritional immunity beyond iron: a role for manganese and zinc
    Thomas E Kehl-Fie
    Vanderbilt University Medical Center, Department of Microbiology and Immunology, USA
    Curr Opin Chem Biol 14:218-24. 2010
    Vertebrates sequester iron from invading pathogens, and conversely, pathogens express a variety of factors to steal iron from the host...
  16. ncbi Iron metabolism in pathogenic bacteria
    C Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX
    Annu Rev Microbiol 54:881-941. 2000
    The ability of pathogens to obtain iron from transferrins, ferritin, hemoglobin, and other iron-containing proteins of their host is central to whether they live or die...
  17. pmc Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli
    Eric Massé
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 17:2374-83. 2003
    ..Thus, this large class of regulatory RNAs share an unexpected intrinsic mechanism for shutting off their action...
  18. ncbi Balancing acts: molecular control of mammalian iron metabolism
    Matthias W Hentze
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Cell 117:285-97. 2004
    b>Iron is ubiquitous in the environment and in biology...
  19. pmc A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat
    Cristobal Uauy
    Department of Plant Sciences, University of California, One Shields Avenue, Davis, CA 95616, USA
    Science 314:1298-301. 2006
    ..positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content...
  20. pmc Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence
    Markus Schrettl
    Dept of Molecular Biology, Medical University Innsbruck, Peter Mayr Str 4b III, A 6020 Innsbruck, Austria
    J Exp Med 200:1213-9. 2004
    The ability to acquire iron in vivo is essential for most microbial pathogens. Here we show that Aspergillus fumigatus does not have specific mechanisms for the utilization of host iron sources...
  21. doi Ferric carboxymaltose in patients with heart failure and iron deficiency
    Stefan D Anker
    Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    N Engl J Med 361:2436-48. 2009
    b>Iron deficiency may impair aerobic performance...
  22. pmc Mammalian iron metabolism and its control by iron regulatory proteins
    Cole P Anderson
    Department of Oncological Sciences, University of Utah, 15 N 2030 E, Salt Lake City, UT 84112, USA
    Biochim Biophys Acta 1823:1468-83. 2012
    Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2)...
  23. pmc Iron storage proteins are essential for the survival and pathogenesis of Mycobacterium tuberculosis in THP-1 macrophages and the guinea pig model of infection
    P Vineel Reddy
    Department of Biochemistry, University of Delhi South Campus, New Delhi, India
    J Bacteriol 194:567-75. 2012
    b>Iron is one of the crucial elements required for the growth of Mycobacterium tuberculosis. However, excess free iron becomes toxic for the cells because it catalyzes the production of reactive oxygen radicals, leading to oxidative damage...
  24. doi Hepcidin and the iron-infection axis
    Hal Drakesmith
    Molecular Immunology Group and Medical Research Council MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Science 338:768-72. 2012
    b>Iron lies at the center of a battle for nutritional resource between higher organisms and their microbial pathogens...
  25. ncbi Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial
    Sunil Sazawal
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Lancet 367:133-43. 2006
    Anaemia caused by iron deficiency is common in children younger than age 5 years in eastern Africa...
  26. ncbi The evolution of iron chelators for the treatment of iron overload disease and cancer
    Danuta S Kalinowski
    The Iron Metabolism and Chelation Program, Children s Cancer Institute Australia for Medical Research, Sydney, New South Wales, Australia
    Pharmacol Rev 57:547-83. 2005
    The evolution of iron chelators from a range of primordial siderophores and aromatic heterocyclic ligands has lead to the formation of a new generation of potent and efficient iron chelators...
  27. pmc TonB-dependent transporters: regulation, structure, and function
    Nicholas Noinaj
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 64:43-60. 2010
    ..Because iron uptake is vital for almost all bacteria, expression of TBDTs is regulated in a number of ways that include metal-..
  28. ncbi Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease
    A R Curtis
    Institute of Human Genetics, 19 20 Claremont Place, Newcastle upon Tyne, NE2 4AA, UK
    Nat Genet 28:350-4. 2001
    ..Brain histochemistry disclosed abnormal aggregates of ferritin and iron. Low serum ferritin levels also characterized patients...
  29. pmc Heme oxygenase 1 is required for mammalian iron reutilization
    K D Poss
    Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:10919-24. 1997
    The majority of iron for essential mammalian biological activities such as erythropoiesis is thought to be reutilized from cellular hemoproteins. Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99...
  30. ncbi Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
    Trude H Flo
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Nature 432:917-21. 2004
    Although iron is required to sustain life, its free concentration and metabolism have to be tightly regulated. This is achieved through a variety of iron-binding proteins including transferrin and ferritin...
  31. ncbi Iron, brain ageing and neurodegenerative disorders
    Luigi Zecca
    Institute of Biomedical Technologies Italian National Research Council, 20090 Segrate, Milano, Italy
    Nat Rev Neurosci 5:863-73. 2004
    There is increasing evidence that iron is involved in the mechanisms that underlie many neurodegenerative diseases...
  32. pmc ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response
    G Marcela Rodriguez
    TB Center, The Public Health Research Institute, Newark, New Jersey 07103, USA
    Infect Immun 70:3371-81. 2002
    ..In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their ..
  33. doi Iron availability and infection
    Eugene D Weinberg
    Department of Biology and Program in Medical Sciences Indiana University, Bloomington, Indiana, IN 47405 USA
    Biochim Biophys Acta 1790:600-5. 2009
    To successfully sustain an infection, nearly all bacteria, fungi and protozoa require a continuous supply of host iron.
  34. ncbi Cloning and characterization of a mammalian proton-coupled metal-ion transporter
    H Gunshin
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 388:482-8. 1997
    ..DCT1 is upregulated by dietary iron deficiency, and may represent a key mediator of intestinal iron absorption...
  35. pmc The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
    Mirco Castoldi
    Department of Pediatric Hematology, Oncology, and Immunology, University of Heidelberg, Heidelberg, Germany
    J Clin Invest 121:1386-96. 2011
    Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release...
  36. pmc Discovery and characterization of a unique mycobacterial heme acquisition system
    Michael V Tullius
    Departments of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:5051-6. 2011
    Mycobacterium tuberculosis must import iron from its host for survival, and its siderophore-dependent iron acquisition pathways are well established. Here we demonstrate a newly characterized pathway, whereby M...
  37. ncbi The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
    Adriana Donovan
    Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Cell Metab 1:191-200. 2005
    Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release. Hepcidin, a regulatory peptide, binds to ferroportin and causes it to be internalized and degraded...
  38. doi Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses
    Zhuzhen Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Blood 118:1912-22. 2011
    Systemic iron requirements are met predominantly through the recycling of iron from senescent erythrocytes by macrophages, a process in which the iron exporter ferroportin (Fpn1) is considered to be essential...
  39. ncbi Nutritional iron deficiency
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Lancet 370:511-20. 2007
    b>Iron deficiency is one of the leading risk factors for disability and death worldwide, affecting an estimated 2 billion people. Nutritional iron deficiency arises when physiological requirements cannot be met by iron absorption from diet...
  40. pmc MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity
    Oliver Stehling
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat Marburg, Robert Koch Str 6, 35033 Marburg, Germany
    Science 337:195-9. 2012
    ..Here, we identify MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery...
  41. pmc Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice
    Jennifer A Gaddy
    Department of Microbiology, Miami University, Oxford, Ohio, USA
    Infect Immun 80:1015-24. 2012
    Acinetobacter baumannii, which causes serious infections in immunocompromised patients, expresses high-affinity iron acquisition functions needed for growth under iron-limiting laboratory conditions...
  42. pmc The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus
    Radhika Jain
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, D 07745 Jena, Germany
    Mol Microbiol 82:39-53. 2011
    ..Consistently, northern and western blot analyses indicated that iron starvation triggers phosphorylation and thus activation of MpkA...
  43. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
    Aspergillus fumigatus, the most common airborne fungal pathogen of humans, employs two high-affinity iron uptake systems: iron uptake mediated by the extracellular siderophore triacetylfusarinine C and reductive iron assimilation...
  44. ncbi A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake
    Laxminarayana R Devireddy
    Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 123:1293-305. 2005
    ..been implicated in diverse physiological processes, including apoptosis due to interleukin-3 (IL-3) deprivation and iron transport. Here we report cloning of the 24p3 cell-surface receptor (24p3R)...
  45. pmc Control of iron homeostasis by an iron-regulated ubiquitin ligase
    Ajay A Vashisht
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 326:718-21. 2009
    Eukaryotic cells require iron for survival and have developed regulatory mechanisms for maintaining appropriate intracellular iron concentrations...
  46. ncbi A novel mammalian iron-regulated protein involved in intracellular iron metabolism
    S Abboud
    Department of Pathology and the Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 275:19906-12. 2000
    We have isolated and characterized a novel iron-regulated gene that is homologous to the divalent metal transporter 1 family of metal transporters...
  47. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
    Superparamagnetic iron oxide particles (SPIO and USPIO) have a variety of applications in molecular and cellular imaging. Most of the recent research has concerned cellular imaging with imaging of in vivo macrophage activity...
  48. ncbi Susceptibility weighted imaging (SWI)
    E Mark Haacke
    Department of Radiology, Wayne State University, Detroit, MI, USA
    Magn Reson Med 52:612-8. 2004
    ..the phase images themselves can provide excellent contrast between gray matter (GM) and white matter (WM), iron-laden tissues, venous blood vessels, and other tissues with susceptibilities that are different from the background ..
  49. pmc Transcriptome response of high- and low-light-adapted Prochlorococcus strains to changing iron availability
    Anne W Thompson
    MIT Department of Civil and Environmental Engineering, Cambridge, MA02139, USA
    ISME J 5:1580-94. 2011
    Prochlorococcus contributes significantly to ocean primary productivity. The link between primary productivity and iron in specific ocean regions is well established and iron limitation of Prochlorococcus cell division rates in these ..
  50. pmc Characterization of Prochlorococcus clades from iron-depleted oceanic regions
    Douglas B Rusch
    J Craig Venter Institute, Rockville, MD 20855, USA
    Proc Natl Acad Sci U S A 107:16184-9. 2010
    ..clades consistently cooccur and dominate the surface waters of high-temperature, macronutrient-replete, and low-iron regions of the Eastern Equatorial Pacific upwelling and the tropical Indian Ocean...
  51. doi Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis
    Tanja Werner
    Biofunctionality, Technische Universitat Munchen, Freising Weihenstephan, Germany
    Gut 60:325-33. 2011
    b>Iron replacement therapy is a common treatment in patients with anaemia and Crohn's disease, but oral iron supplements are less tolerated...
  52. ncbi Iron and microbial infection
    Ulrich E Schaible
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117, Berlin, Germany
    Nat Rev Microbiol 2:946-53. 2004
    The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts...
  53. pmc IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, California, USA
    J Clin Invest 113:1271-6. 2004
    ..In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin are largely ..
  54. pmc The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots
    Terri A Long
    Department of Biology and Institute for Genome Science and Policy Center for Systems Biology, Duke University, Durham, North Carolina 27708, USA
    Plant Cell 22:2219-36. 2010
    ..and climate change underscore the need for better comprehension of how plants acquire and process nutrients such as iron. Using cell type-specific transcriptional profiling, we identified a pericycle-specific iron deficiency response ..
  55. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe). This complex converts renal progenitors into epithelial tubules...
  56. ncbi A ferric-chelate reductase for iron uptake from soils
    N J Robinson
    Department of Biochemistry and Genetics, The Medical School, University of Newcastle, UK
    Nature 397:694-7. 1999
    b>Iron deficiency afflicts more than three billion people worldwide, and plants are the principal source of iron in most diets...
  57. ncbi A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
    B Zhou
    Howard Hughes Medical Institute and Departments of Medicine and Pediatrics, University of California, Parnassus and Third Avenues, U 426, San Francisco, California 94143, USA
    Nat Genet 28:345-9. 2001
    Hallervorden-Spatz syndrome (HSS) is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain...
  58. pmc An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis
    Changbin Chen
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco, USA
    Cell Host Microbe 10:118-35. 2011
    ..tract and bloodstream are highly disparate biological niches that differ in concentrations of nutrients such as iron. However, some commensal-pathogenic microorganisms, such as the yeast Candida albicans, thrive in both environments...
  59. doi The role of iron and reactive oxygen species in cell death
    Scott J Dixon
    1 Department of Biological Sciences, Columbia University, New York, New York, USA 2 Department of Biology, Stanford University, Stanford, California, USA
    Nat Chem Biol 10:9-17. 2014
    The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive oxygen species (ROS) are unavoidable in an oxygen-rich environment...
  60. pmc Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples
    Douglas B Kell
    School of Chemistry and The Manchester Interdisciplinary Biocentre, The University of Manchester, Manchester M1 7DN, UK
    Arch Toxicol 84:825-89. 2010
    ..based on positive feedback mechanisms) of hydroxyl radicals via Fenton chemistry involving poorly liganded iron, leading to cell death via apoptosis (probably including via pathways induced by changes in the NF-κB system)...
  61. ncbi Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload
    L J Anderson
    Cardiovascular MR Unit, Royal Brompton Hospital, London, UK
    Eur Heart J 22:2171-9. 2001
    AIMS: To develop and validate a non-invasive method for measuring myocardial iron in order to allow diagnosis and treatment before overt cardiomyopathy and failure develops...
  62. pmc Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles
    Jeremiah J Faith
    Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America
    PLoS Biol 5:e8. 2007
    ..CLR also identified a regulatory link providing central metabolic control of iron transport, which we confirmed with real-time quantitative PCR...
  63. ncbi Importance of iron chelation in free radical-induced oxidative stress and human disease
    Klaudia Jomova
    Department of Chemistry, Faculty of Natural Sciences, Constantine the Philosopher University, Nitra, Slovakia
    Curr Pharm Des 17:3460-73. 2011
    b>Iron is a redox active metal involved in the oxidation-reduction reactions and regulation of cell growth and differentiation. Iron is an integral part of many proteins and enzymes that maintains various physiological functions...
  64. ncbi Iron and metal regulation in bacteria
    K Hantke
    Mikrobiologie Membranphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, D 72076, Tubingen, Germany
    Curr Opin Microbiol 4:172-7. 2001
    In Escherichia coli, the iron regulator Fur is regulated by two oxidative-stress response regulators. The generation of dangerous radicals by oxygen and iron is the basis for this dual regulation, which is also found in eukaryotes...
  65. doi Lack of the bone morphogenetic protein BMP6 induces massive iron overload
    Delphine Meynard
    INSERM, U563, Toulouse, France
    Nat Genet 41:478-81. 2009
    Expression of hepcidin, a key regulator of intestinal iron absorption, can be induced in vitro by several bone morphogenetic proteins (BMPs), including BMP2, BMP4 and BMP9 (refs. 1,2)...
  66. pmc Microarray analysis of the nitrate response in Arabidopsis roots and shoots reveals over 1,000 rapidly responding genes and new linkages to glucose, trehalose-6-phosphate, iron, and sulfate metabolism
    Rongchen Wang
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla 92093 0116, USA
    Plant Physiol 132:556-67. 2003
    ..phosphoglycerate mutase), in trehalose-6-P metabolism (trehalose-6-P synthase and trehalose-6-P phosphatase), in iron transport/metabolism (nicotianamine synthase), and in sulfate uptake/reduction...
  67. pmc An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
    Anca Sindrilaru
    Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany
    J Clin Invest 121:985-97. 2011
    ..Here, we have shown that iron overloading of macrophages--as was found to occur in human chronic venous leg ulcers and the mouse model--induced a ..
  68. pmc On T2* magnetic resonance and cardiac iron
    John Paul Carpenter
    Royal Brompton and Harefield NHS Trust, London, SW3 6NP, UK
    Circulation 123:1519-28. 2011
    Measurement of myocardial iron is key to the clinical management of patients at risk of siderotic cardiomyopathy...
  69. ncbi Regulation of ferritin genes and protein
    Frank M Torti
    Department of Cancer Biology and Biochemistry and the Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Blood 99:3505-16. 2002
  70. doi High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption
    Thomas Sonnweber
    Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria
    J Nutr Biochem 23:1600-8. 2012
    Obesity is often associated with disorders of iron homeostasis; however, the underlying mechanisms are not fully understood. Hepcidin is a key regulator of iron metabolism and may be responsible for obesity-driven iron deficiency...
  71. pmc A non-heme iron-mediated chemical demethylation in DNA and RNA
    Chengqi Yi
    Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Acc Chem Res 42:519-29. 2009
    ..AlkB uses a non-heme mononuclear iron(II) and the cofactors 2-ketoglutarate (2KG) and dioxygen to effect oxidative demethylation of the DNA base lesions ..
  72. pmc Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis
    Shashi Chillappagari
    Department of Chemistry Biochemistry, Philipps University Marburg, Hans Meerwein Str, D 35032 Marburg, Germany
    J Bacteriol 192:2512-24. 2010
    Copper and iron are essential elements for cellular growth. Although bacteria have to overcome limitations of these metals by affine and selective uptake, excessive amounts of both metals are toxic for the cells...
  73. pmc Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis
    Batool A Haider
    Departments of Epidemiology and Nutrition, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMJ 346:f3443. 2013
    To summarise evidence on the associations of maternal anaemia and prenatal iron use with maternal haematological and adverse pregnancy outcomes; and to evaluate potential exposure-response relations of dose of iron, duration of use, and ..
  74. pmc Iron and neurodegeneration in the multiple sclerosis brain
    Simon Hametner
    Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Ann Neurol 74:848-61. 2013
    b>Iron may contribute to the pathogenesis and progression of multiple sclerosis (MS) due to its accumulation in the human brain with age...
  75. ncbi Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity
    Des R Richardson
    Iron Metabolism and Chelation Program, Department of Pathology, University of Sydney, Sydney, New South Wales 2006, Australia
    J Med Chem 49:6510-21. 2006
    There has been much interest in the development of iron (Fe) chelators for the treatment of cancer...
  76. doi Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo
    Sorina Radulescu
    Beatson Institute of Cancer Research, Glasgow, UK
    Cell Rep 2:270-82. 2012
    It is clear from epidemiological studies that excess iron is associated with increased risk of colorectal cancer; however, questions regarding the mechanism of how iron increases cancer risk, the source of the excess iron (circulating or ..
  77. pmc The PICALM protein plays a key role in iron homeostasis and cell proliferation
    Paula B Scotland
    Division of Pediatric Hematology Oncology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS ONE 7:e44252. 2012
    ..Inactivating and hypomorphic Picalm mutations in mice cause different degrees of severity of anemia, abnormal iron metabolism, growth retardation and shortened lifespan...
  78. ncbi Bacterial iron homeostasis
    Simon C Andrews
    School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    FEMS Microbiol Rev 27:215-37. 2003
    b>Iron is essential to virtually all organisms, but poses problems of toxicity and poor solubility...
  79. ncbi Biofortification: a new tool to reduce micronutrient malnutrition
    Howarth E Bouis
    International Food Policy Research Institute, 2033 K Street NW, Washington, DC 20006, USA
    Food Nutr Bull 32:S31-40. 2011
    ..The density of minerals and vitamins in food staples eaten widely by the poor may be increased either through conventional plant breeding or through the use of transgenic techniques, a process known as biofortification...
  80. doi The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre
    Johannes Fritsch
    Mikrobiologie, Institut fur Biologie, Humboldt Universitat zu Berlin, Chausseestraße 117, 10115 Berlin, Germany
    Nature 479:249-52. 2011
    ..centre in the H(2)-reduced state and a small subunit containing an electron relay consisting of three different iron-sulphur clusters...
  81. pmc Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice
    Emily G Farrow
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 108:E1146-55. 2011
    ..This onset may occur in physiological states associated with iron deficiency, including puberty and pregnancy...
  82. pmc Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans
    Daniel Ackerman
    Institute of Healthy Aging and Department of Genetics Evolution and Environment, University College London, London, United Kingdom
    PLoS Genet 8:e1002498. 2012
    b>Iron plays an essential role in many biological processes, but also catalyzes the formation of reactive oxygen species (ROS), which can cause molecular damage. Iron homeostasis is therefore a critical determinant of fitness...
  83. doi Iron dysregulation in movement disorders
    Petr Dusek
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Neurobiol Dis 46:1-18. 2012
    b>Iron is an essential element necessary for energy production, DNA and neurotransmitter synthesis, myelination and phospholipid metabolism...
  84. pmc Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression
    Timothy J Brickman
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Bacteriol 193:4798-812. 2011
    ..pertussis perceives an iron starvation cue and expresses multiple iron source utilization systems in its natural human host environment...
  85. pmc Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA, USA
    Prog Neurobiol 94:296-306. 2011
    ..Although questioned by some, brain copper, zinc, and particularly iron overload are widely accepted features of AD which have led to the hypothesis that oxidative stress generated from ..
  86. pmc Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes
    Daili J A Netz
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat Marburg, Marburg, Germany
    Nat Chem Biol 8:125-32. 2012
    ..Together, our findings show that the function of eukaryotic replicative DNA polymerases crucially depends on different metallocenters for accessory subunit recruitment and replisome stability...
  87. pmc IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth
    Grégory Vert
    Biochimie et Physiologie Moleculaire des Plantes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5004, Universite Montpellier II, 2 place Viala, F 34060 Montpellier Cedex 1, France
    Plant Cell 14:1223-33. 2002
    Plants are the principal source of iron in most diets, yet iron availability often limits plant growth. In response to iron deficiency, Arabidopsis roots induce the expression of the divalent cation transporter IRT1...
  88. ncbi The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism
    E Virginia Armbrust
    School of Oceanography, University of Washington, Seattle, WA 98195, USA
    Science 306:79-86. 2004
    ..We identified novel genes for silicic acid transport and formation of silica-based cell walls, high-affinity iron uptake, biosynthetic enzymes for several types of polyunsaturated fatty acids, use of a range of nitrogenous ..
  89. ncbi Anemia of chronic disease
    Guenter Weiss
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria
    N Engl J Med 352:1011-23. 2005
  90. doi Iron homeostasis and management of oxidative stress response in bacteria
    Pierre Cornelis
    Microbial Interactions, Department of Molecular and Cellular Interactions, VIB and Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
    Metallomics 3:540-9. 2011
    b>Iron is both an essential nutrient for the growth of microorganisms, as well as a dangerous metal due to its capacity to generate reactive oxygen species (ROS) via the Fenton reaction...
  91. pmc Frataxin and mitochondrial FeS cluster biogenesis
    Timothy L Stemmler
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 285:26737-43. 2010
    ..Frataxin interacts with Isu, iron, and the cysteine desulfurase Nfs1, which supplies sulfide, thus placing it at the center of mitochondrial FeS ..
  92. pmc Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis
    Masako Kohyama
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 457:318-21. 2009
    ..Red pulp macrophages highly express genes involved in capturing circulating haemoglobin and in iron regulation...
  93. ncbi Superparamagnetic iron oxide nanoparticle probes for molecular imaging
    Daniel L J Thorek
    Cellular and Molecular Imaging Group, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Ann Biomed Eng 34:23-38. 2006
    ..In particular, superparamagnetic iron oxide nanoparticles (SPIO) have demonstrated their utility as an important tool for enhancing magnetic resonance ..
  94. pmc Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD
    Jodie L Babitt
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Kidney Dis 55:726-41. 2010
    ..in patients with CKD currently revolves around the use of erythropoiesis-stimulating agents and supplemental iron. However, many patients do not respond adequately and/or require high doses of these medications...
  95. ncbi The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer
    Tracy R Daniels
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Clin Immunol 121:144-58. 2006
    The transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and in the regulation of cell growth...
  96. pmc The mechanism of iron homeostasis in the unicellular cyanobacterium synechocystis sp. PCC 6803 and its relationship to oxidative stress
    Sigal Shcolnick
    Alexander Silberman Institute of Life Sciences, Department of Plant and Environmental Sciences, Hebrew University of Jerusalem, Edmond Safra Campus Givat Ram, Jerusalem 91904, Israel
    Plant Physiol 150:2045-56. 2009
    In this article, we demonstrate the connection between intracellular iron storage and oxidative stress response in cyanobacteria. Iron is essential for the survival of all organisms...
  97. ncbi Imaging iron stores in the brain using magnetic resonance imaging
    E Mark Haacke
    The MRI Institute for Biomedical Research, 440 East Ferry Street, Detroit, MI 48202, USA
    Magn Reson Imaging 23:1-25. 2005
    For the last century, there has been great physiological interest in brain iron and its role in brain function and disease...
  98. pmc Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells
    Jörg Linde
    Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Jena, Germany
    BMC Syst Biol 4:148. 2010
    ..During the infection process, this fungus is able to adapt to conditions of very low iron availability. Such adaptation is an important virulence attribute of virtually all pathogenic microbes...
  99. pmc Iron in innate immunity: starve the invaders
    Tomas Ganz
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, United States
    Curr Opin Immunol 21:63-7. 2009
    b>Iron is essential for nearly all living organisms. Innate immunity effectively restricts iron availability to microbial invaders. Some microbes have evolved effective countermeasures that blunt the effect of iron restriction...
  100. doi The relevance of iron in the pathogenesis of Parkinson's disease
    Jeswinder Sian-Hülsmann
    Clinical Neurochemistry, National Parkinson Foundation Centre of Excellence Laboratories, Clinic and Polyclinic for Psychiatry, Psychosomatic and Psychotherapy, Medical School, University of Wurzburg, Wurzburg, Germany
    J Neurochem 118:939-57. 2011
    Alterations of iron levels in the brain has been observed and documented in a number of neurodegenerative disorders including Parkinson's disease (PD)...
  101. pmc Saccharides enhance iron bioavailability to Southern Ocean phytoplankton
    Christel S Hassler
    Centre for Australian Weather and Climate Research, a partnership between Commonwealth Scientific and Industrial Research Organisation and Bureau of Meteorology, Hobart, Tasmania 7000, Australia
    Proc Natl Acad Sci U S A 108:1076-81. 2011
    b>Iron limits primary productivity in vast regions of the ocean...

Research Grants76

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Pathogens are transmitted by blood transfusion, and altered host immunity from hypersplenism and iron overload contribute to the morbidity...
  2. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..Prolonged exposure to iron of the heart, liver, endocrine glands and other tissues results in severe oxidant damage, organ failure, malignant ..
  3. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Improved iron chelators are required with the lifelong transfusion treatment of the genetic anemias, Sickle Cell Disease (SCD) and the Thalassemias (THL), because the regular blood transfusions, lead ..
  4. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): High iron levels in blood and tissues are a risk factor for diabetes mellitus...
  5. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..This disorder typically manifests itself as a hypoproliferative anemia accompanied by a low serum iron concentration despite adequate reticuloendothelial iron stores...
  6. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
    ..The proposal involves the application of a novel assay for the iron metabolism hormone hepcidin in the approach to prevent, diagnose, and treat iron deficiency in infants...
  7. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Iron is an essential co-factor for many enzymes that play a vital role in cellular processes...
  8. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2013
    ..Its putative normal function is the biogenesis of iron- sulfur (Fe-S) clusters conveying iron homeostasis to the entire cell...
  9. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..Abnormal levels of bio-essential metals (iron, copper, and zinc) as well as toxic trace elements (mercury, lead, cadmium, and arsenic) are known to be associated ..
  10. Tissue-specific delivery of probes by control of membrane trafficking of endoprot
    Blake Peterson; Fiscal Year: 2010
    ..The way that Nature solves this problem is through membrane trafficking;cell impermeable ligands such as the iron-carrying transferrin protein bind cognate receptors, in this case the transferrin receptor, that reside in dynamic ..
  11. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..The most reactive and toxic ROS is the hydroxyl radical (OH7) formed by the iron- catalyzed Fenton reaction...
  12. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012
    Mitochondria are critical in iron metabolism and play a role in alcohol-induced liver injury. Alcohol alters mitochondrial function and leads to oxidative stress...
  13. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ..heme transport and utilization at the cellular level, and the impact of heme cellular pathways on nutritional iron metabolism. Heme is essential for virtually all organisms...
  14. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    ..aging, I will perform dual energy absorptiometry (DXA) to determine muscle mass;analyze fiber types, fat content, iron content, antioxidant enzymes and oxidative damage levels of muscle to determine muscle quality;analyze ..
  15. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Iron is essential for cell growth and proliferation due to its role as prosthetic group in proteins required for DNA synthesis and energy metabolism...
  16. The Mucolipin TRP Ion Channels
    Haoxing Xu; Fiscal Year: 2013
    ..ML4 patients exhibit motor defects, mental retardation, retinal degeneration, and iron-deficiency anemia...
  17. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
    ..with HFE (a hereditary hemochromatosis associated gene)-TFRC (Transferrin Receptor)-TF (Transferrin) complex and iron transport, thus provokes downstream redox signaling changes with microRNAs (miRNAs) serving as regulators for a ..
  18. Mechanistic Characterization and Genetic Analysis of Systemic Iron Homeostasis
    Xin Du; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): As a component of heme and a constituent of many iron-dependent enzymes, iron is essential for oxidative phosphorylation, erythropoiesis, and many other chemical reactions that are vital for survival ..
  19. METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIA
    DOUGLAS CORBETT HEIMBURGER; Fiscal Year: 2010
    ..analytes (sodium, chloride, bicarbonate, urea nitrogen, and creatinine), selected micronutrients (ferritin for iron status, folic acid, vitamins A, B12, and E, and selenium), and inflammatory markers (C-reactive protein and 1-1-..
  20. Modifiers of hepcidin expression as new therapies for iron overload
    PAULA GOODMAN FRAENKEL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Iron overload syndromes remain important causes of heart and liver failure in patients with thalassemia or hereditary hemochromatosis, which are common genetic diseases worldwide...
  21. Iron, NO, and Lipid Peroxide in Photodynamic Therapy
    ALBERT GIROTTI; Fiscal Year: 2013
    ..radicals or by signaling for heme oxygenase-1 and ferritin induction, leading to depletion of prooxidant iron. We recently discovered that NO is overproduced by ALA/light-stressed breast tumor cells due to rapid and prolonged ..
  22. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..Research conducted under NIAID AI52747 studied the molecular biology of heme-iron scavenging in staphylococci and identified the molecular properties of iron-regulated surface determinants (IsdA-I)...
  23. Regulation of insulator function and globin gene expression by USF and associated
    Suming Huang; Fiscal Year: 2013
    ..exchange oxygen, depends on hemoglobin, a heterotetramer composed of two a and two -globin chains and associated iron-binding heme groups...
  24. Electron Transfer in Iron and Copper Proteins
    Jay R Winkler; Fiscal Year: 2013
    ..Efforts will focus on oxidative generation of Compounds I and II in cytochromes P450 (Aim 3) and a bacterial enzyme that exhibits NOS-like reactivity (Aim 4). ..
  25. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    ..Past pathophysiological studies have associated RLS to the disorder of the central dopaminergic system and iron metabolism. Family and twin studies strongly support a genetic contribution to the pathogenesis of RLS...
  26. Biological Functions of Iron Responsive Elements
    Richard S Eisenstein; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Disorders of iron metabolism, whether caused by inborn genetic errors, maladaptive responses to disease or diet are major public health issues in the U.S. and throughout the world...
  27. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    ..worldwide, is the liver scarring response to chronic injury from viral hepatitis B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress to liver cirrhosis, liver failure and death...
  28. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE (provided by applicant): Free radicals play a major role in human diseases such as iron sulfate poisoning, ionizing radiation, oxygen toxicity in premature infants treated with hyperbaric oxygen, ..
  29. Delivery issues in lung cancer CNS metastases
    Edward A Neuwelt; Fiscal Year: 2013
    ..Dynamic susceptibility-weighted MRI with the iron oxide nanoparticle blood pool agent ferumoxytol provides a measure of tumor blood volume while dynamic contrast-..
  30. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE (provided by applicant): Free radicals play a major role in human diseases such as iron sulfate poisoning, ionizing radiation, oxygen toxicity in premature infants treated with hyperbaric oxygen, ..
  31. Understand and Improve Iron Distribution and Erythropoiesis in Beta-Thalassemia
    Yelena Ginzburg; Fiscal Year: 2013
    ..Beta-thalassemia in humans is a disease associated with anemia, splenomegaly, and ineffective erythropoiesis;iron overload in this disease results from transfusion and increased iron absorption from hepcidin deficiency...
  32. NEWBORN IRON DEFICIENCY
    Michael K Georgieff; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Iron deficiency (ID) is one of the most common nutrient deficiencies worldwide, affecting two billion people and up to 30% of all pregnant women and their offspring...
  33. Biosynthetic Protein Models of Heme-copper Oxidases and Nitric Oxide Reductases
    Yi Lu; Fiscal Year: 2013
    ..center as in heme-copper oxidases (HCO), and is effective at N-N bond formation when using a heme-non-heme iron center, as in nitric oxide reductase (NOR)...
  34. New Investigation Initiatives for the Prevention of Complications of Thalassemia
    Ellis J Neufeld; Fiscal Year: 2011
    ..In addition, with transfusions comes obligatory iron overload, and iron-related heart disease, liver disease, and endocrinopathies are major causes of morbidity and ..
  35. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..focusing on genetic variations in 4 pathways chosen to reflect metal metabolism or synaptic plasticity: iron metabolism (HFE, transferrin, DMT-1), cholesterol metabolism (apolipoprotein E), neurotransmitter metabolism (..
  36. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    ..Can maternal preconception iron status modify the associations between exposure to DDT/DDE and the reproductive outcomes outlined in Aim 1? Aim 4...
  37. Haemophilus influenzae iron/heme regulon
    Terrence L Stull; Fiscal Year: 2012
    ..We have characterized several of the heme and iron acquisition systems of H...
  38. DNA Repair of Endogenous Lesions in Carcinogenesis
    Rabindra Roy; Fiscal Year: 2010
    ..if any, of DNA glycosylase(s) and/or other rate-limiting BER enzymes by assessing the effects of metals (copper and iron), hydrogen peroxide, and enals in hepatocytes of LEA and LEG rats and comparing the effects with that observed in ..
  39. High-Tc susceptometer to monitor transfusional iron overload (NSR device)
    Gary M Brittenham; Fiscal Year: 2012
    ..by liquid nitrogen) superconducting magnetic susceptometer as the most clinically effective means for monitoring iron overload in patients who require chronic red blood cell transfusion...
  40. Tyrosinase Model Complexes using Imidazole Ligands
    JOHN BRANNON GARY; Fiscal Year: 2013
    ..Such findings of the biological relevance of Cu(III) would provide a complete paradigm shift in copper biochemistry (e.g. Fe(IV)-oxo intermediates for non-heme iron sites).
  41. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..cysteine, folate, lutein, lycopene, oleic acid, pro-vitamin A, vitamins C and E, zinc) or promote it (iron, saturated fat);2) methyl group metabolism - betaine, choline, folate, methionine, riboflavin, vitamin B6, vitamin ..
  42. Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular Risk
    Sheila Gahagan; Fiscal Year: 2012
    ..and 10 years as part of a NIH-supported cohort study of the behavioral and developmental effects of preventing iron deficiency anemia in infancy (n = 1645)...
  43. Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and Prosta
    Iona Cheng; Fiscal Year: 2012
    ..environmental factors related to mitochondrial activity (smoking, BMI, fat, carotenoids, vitamin C, vitamin E, iron, lycopene and selenium) and susceptibility loci for breast, colorectal and/or prostate cancer identified by genome-..
  44. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
    ..Susceptibility factors include hepatitis C, alcohol use, smoking, iron overload, HIV, estrogens and an inherited partial deficiency of UROD...
  45. Biological Functions of Iron Responsive Elements
    Richard S Eisenstein; Fiscal Year: 2013
    Project Summary: Disorders of iron metabolism, whether caused by inborn genetic errors, maladaptive responses to disease, or diet are major public health issues in the U.S. and throughout the world...
  46. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Iron overload is common in patients undergoing hematopoietic cell transplantation (HCT) and recent reports show increased non-relapse mortality in patients with iron overload as determined by ..
  47. Environment, Novel Aging Outcomes, and Genetics
    Sung Kyun Park; Fiscal Year: 2013
    ..examine independent effects of lead and traffic-related particles, but focus on genes involved in the pathway of iron regulation metabolism which may modify the lead and particle responses...
  48. Mechanisms of Cell Death after Photodynamic Therapy
    Anna Liisa Nieminen; Fiscal Year: 2010
    ..We hypothesize that damage to these organelles by PC 4 and PC 181 leads to additional perturbations, such as Ca2+, iron and protease release that ultimately promote MPT-dependent cell killing after PDT...
  49. Malaria and the safety of iron interventions: absorption and NTBI
    Gary M Brittenham; Fiscal Year: 2012
    ..the effects of acute infection with Plasmodium falciparum on the absorption, pharmacokinetics and metabolism of iron from iron supplements and other Iron preparations in women of childbearing age...
  50. Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    ANDRE ELIAS NEL; Fiscal Year: 2010
    ..which have been designed to (i) adjust the toxic effects of ZnO nanoparticles by changing Zn++ release through iron doping, (ii) adjust the cytotoxicity of cationic mesoporous silica nanoparticles (MSNP) by scaling back the surface ..
  51. Development of New Molecular Probes for Diagnostic Imaging of Atherosclerosis
    KAREN CATHERIN BRILEY SAEBO; Fiscal Year: 2010
    ..Since the FDA has already approved the use manganese (Mn(II)) chelates and iron oxide particles for MR liver indications, we hypothesize that oxLDL targeted Mn(II) micelles and oxLDL targeted ..
  52. Redox regulation in aging and failing heart
    Junichi Sadoshima; Fiscal Year: 2013
    ..O2- inactivates iron-sulfur cluster containing enzymes, thereby liberating free iron, which in turn generates the highly reactive ..
  53. An internet based prospective study of time to pregnancy
    Elizabeth E Hatch; Fiscal Year: 2013
    ..research, we will collect exposure data on dietary factors, such as fatty acids, folic acid, dairy foods, and iron intake, using a validated food frequency questionnaire...
  54. Nonheme Diiron Centers and the Biological Oxidation of Hydrocarbons
    Stephen J Lippard; Fiscal Year: 2013
    ..methane-utilizing and related bacteria selectively oxidize hydrocarbons for energy and food by activating oxygen at iron centers housed in their hydroxylase enzymes...
  55. Transferrin Conjugates for Oral Protein Drug Delivery
    Wei Chiang Shen; Fiscal Year: 2013
    ..The objective of this application is to develop recombinant proteins by fusing protein drugs with an iron-carrying protein, transferrin, to promote oral absorption...
  56. Iron Acquisition by Mycobacterium tuberculosis Within Phagocytes
    Bradley E Britigan; Fiscal Year: 2013
    ..tb during lung infection. M.tb metabolism in macrophages and dendritic cells may differ. Iron (Fe) acquisition is critical for M.tb growth...
  57. Mechanisms that Regulate Neonatal Lung Heme Oxygenase in Hyperoxia
    Phyllis A Dennery; Fiscal Year: 2013
    ..reaction catalyzed by HO, heme is degraded to generate equimolar quantities of biologically active products such as iron, biliverdin, and carbon monoxide (CO) possibly accounting for the cytoprotective effects attributed to HO-1...
  58. Heme trafficking and its impact on systemic iron homeostasis
    Janis L Abkowitz; Fiscal Year: 2010
    The goal of this project is to study how heme trafficking might impact systemic iron homeostasis...
  59. Mechanisms of Asbestos-Induced Alveolar Epithelial Cell Injury
    David W Kamp; Fiscal Year: 2013
    ..We have shown that iron-derived reactive oxygen species (ROS) from the mitochondria electron transport chain (ETC) mediate asbestos-induced ..
  60. Regulation of Streptomyces differentiation and antibiotic production by SoxR
    Monica Chander; Fiscal Year: 2010
    ..Together, these experiments will provide further insight into redox-sensing and transduction mechanisms by iron-sulfur regulatory proteins...
  61. A Comparative Approach to Globin Regulation/Thalassemia
    LEONARD IRA ZON; Fiscal Year: 2012
    ..These factors fall into four categories: the production of heme, iron utilization, globin expression, and iron sulfur cluster production...
  62. Heme trafficking and its impact on systemic iron homeostasis
    Janis L Abkowitz; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): The goal of this project is to study how heme trafficking might impact systemic iron homeostasis...
  63. CYTOSKELETAL REGULATION OF VESICLE TRANSPORT IN LIVER
    MARK A MC NIVEN; Fiscal Year: 2013
    ..These processes are essential for normal iron homeostasis, growth factor receptor signaling, and cell survival...
  64. REGULATORS OF IRON ABSORPTION
    MARCEL CONRAD; Fiscal Year: 2000
    A hypothetical model for iron absorption was developed from discovery of three 'new' iron binding proteins in rat and human duodenal mucosa...
  65. Iron Delivery Via hemodialysate in ESRD
    Ajay Gupta; Fiscal Year: 2005
    ..EPO stimulated iron utilization, coupled with small but unavoidable loss of extra corporeal blood with hemodialysis, leads to iron ..
  66. Cardiac Function and Cardiac iron (T2*) in Thalassemia
    John Wood; Fiscal Year: 2007
    ..Each transfusion contributes more than a year's dietary iron intake, producing toxic iron overload in many organ systems including the heart...
  67. Enhancing Dietary Iron and Zinc Bioavailability in Indian Children
    Steven A Abrams; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Background: Iron and zinc deficiencies frequently occur together because the dietary factors that impair iron absorption also affect zinc absorption...
  68. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2005
    Alternatives to current management strategies for managing dietary iron deficiency can help compensate for the relative expense of food supplementation, for noncompliance with specific therapies and for interactions between supplements ..
  69. Low-Cost, Noninvasive Liver Iron Measurements in African American Iron Overload
    William F Avrin; Fiscal Year: 2010
    ..provided by applicant): This STTR program will test the utility of a low-cost device for noninvasive liver iron measurements, by using the device to determine the prevalence of iron overload in African Americans...
  70. Intestinal Iron Transport in Iron Deficiency/Anemia
    James Collins; Fiscal Year: 2005
    Intestinal iron absorption is mediated by several proteins that have only recently been identified...
  71. REGULATORS OF IRON ABSORPTION
    MARCEL CONRAD; Fiscal Year: 1992
    Consistent discrepancies in the regulation of iron absorption in the proximal small intestine result in either iron deficiency or iron overloading. Regulation is not adequately explained by mucosal transferrin and ferritin...
  72. CHELATION THERAPY OF IRON OVERLOAD WITH PIH
    Gary Brittenham; Fiscal Year: 1993
    ..and effectiveness of orally administered pyridoxal isonicotinoyl hydrazone (PIH) for the chronic treatment of iron overload...
  73. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004
    ..While a limited number of GBS virulence determinants have been identified, the contribution of iron and iron acquisition to the pathogenesis of GBS infection is unknown...
  74. 2012 Iron Sulfur Enzymes Gordon Research Conference
    Markus W Ribbe; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): This application requests partial support for a meeting on Iron Sulfur Enzymes as part of a the Gordon Research Conference series to be held in Mount Holyoke College (South Hadley, MA) on June 10-15, ..
  75. Modulation of Iron Deposition in SCD and Other Hemoglobinopathies
    ELLIOTT P contact VICHINSKY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In thalassemia major (TM), the complications of transfusional iron (Fe) overload and the benefits of chelation therapy are well defined...
  76. BLOOD TISSUE IRON DEPLETION BY EXTRACORPOREAL CHELATOR
    CLARA AMBRUS; Fiscal Year: 1991
    ..Phase I application is to develop a device with immobilized chelator of clinical capacity, for removal of excess iron from patients with iron overload. Dr...