gold

Summary

Summary: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.

Top Publications

  1. doi Biological applications of gold nanoparticles
    Ralph A Sperling
    Fachbereich Physik, Philipps Universitat Marburg, Renthof 7, 35037 Marburg, Germany
    Chem Soc Rev 37:1896-908. 2008
  2. ncbi Size-dependent cytotoxicity of gold nanoparticles
    Yu Pan
    Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Small 3:1941-9. 2007
  3. ncbi Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity
    Ellen E Connor
    Department of Basic Pharmaceutical Sciences, University of South Carolina, Columbia, SC 29208, USA
    Small 1:325-7. 2005
  4. ncbi Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods
    Xiaohua Huang
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Am Chem Soc 128:2115-20. 2006
  5. ncbi Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
    Marie Christine Daniel
    Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
    Chem Rev 104:293-346. 2004
  6. pmc Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
    L R Hirsch
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
    Proc Natl Acad Sci U S A 100:13549-54. 2003
  7. ncbi Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th Floor, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 7:1542-50. 2007
  8. doi Surface charge of gold nanoparticles mediates mechanism of toxicity
    Nicole M Schaeublin
    Applied Biotechnology Branch, Human Effectiveness Directorate, 711 Human Performance Wing, Air Force Research Laboratory, Area B, R Street, Bldg 837, Wright Patterson AFB, OH 45433 5707, USA
    Nanoscale 3:410-20. 2011
  9. doi The golden age: gold nanoparticles for biomedicine
    Erik C Dreaden
    Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
    Chem Soc Rev 41:2740-79. 2012
  10. ncbi Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine
    Prashant K Jain
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia, Institute of Technology, Atlanta, Georgia 30332 0400, USA
    J Phys Chem B 110:7238-48. 2006

Detail Information

Publications378 found, 100 shown here

  1. doi Biological applications of gold nanoparticles
    Ralph A Sperling
    Fachbereich Physik, Philipps Universitat Marburg, Renthof 7, 35037 Marburg, Germany
    Chem Soc Rev 37:1896-908. 2008
    This critical review gives a short overview of the widespread use of gold nanoparticles in biology...
  2. ncbi Size-dependent cytotoxicity of gold nanoparticles
    Yu Pan
    Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Small 3:1941-9. 2007
    b>Gold nanoparticles are widely used in biomedical imaging and diagnostic tests. Based on their established use in the laboratory and the chemical stability of Au(0), gold nanoparticles were expected to be safe...
  3. ncbi Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity
    Ellen E Connor
    Department of Basic Pharmaceutical Sciences, University of South Carolina, Columbia, SC 29208, USA
    Small 1:325-7. 2005
  4. ncbi Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods
    Xiaohua Huang
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Am Chem Soc 128:2115-20. 2006
    ..b>Gold nanorods with suitable aspect ratios (length divided by width) can absorb and scatter strongly in the NIR region (..
  5. ncbi Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
    Marie Christine Daniel
    Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
    Chem Rev 104:293-346. 2004
  6. pmc Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
    L R Hirsch
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
    Proc Natl Acad Sci U S A 100:13549-54. 2003
    ..Tissues heated above the thermal damage threshold displayed coagulation, cell shrinkage, and loss of nuclear staining, which are indicators of irreversible thermal damage. Control tissues appeared undamaged...
  7. ncbi Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th Floor, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 7:1542-50. 2007
    We investigated the mechanism by which transferrin-coated gold nanoparticles (Au NP) of different sizes and shapes entered mammalian cells...
  8. doi Surface charge of gold nanoparticles mediates mechanism of toxicity
    Nicole M Schaeublin
    Applied Biotechnology Branch, Human Effectiveness Directorate, 711 Human Performance Wing, Air Force Research Laboratory, Area B, R Street, Bldg 837, Wright Patterson AFB, OH 45433 5707, USA
    Nanoscale 3:410-20. 2011
    Recently gold nanoparticles (Au NPs) have shown promising biological and military applications due to their unique electronic and optical properties...
  9. doi The golden age: gold nanoparticles for biomedicine
    Erik C Dreaden
    Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
    Chem Soc Rev 41:2740-79. 2012
    b>Gold nanoparticles have been used in biomedical applications since their first colloidal syntheses more than three centuries ago...
  10. ncbi Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine
    Prashant K Jain
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia, Institute of Technology, Atlanta, Georgia 30332 0400, USA
    J Phys Chem B 110:7238-48. 2006
    ..and scattering efficiencies and optical resonance wavelengths for three commonly used classes of nanoparticles: gold nanospheres, silica-gold nanoshells, and gold nanorods...
  11. doi Potential oxidative stress of gold nanoparticles by induced-NO releasing in serum
    Hong Ying Jia
    State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P R China
    J Am Chem Soc 131:40-1. 2009
    Nitric oxide (NO)-release in blood serum initiated by gold nanoparticles has been prove to be a reaction between RSNO and the gold nanoparitcles...
  12. ncbi Modification of gold nanorods using phosphatidylcholine to reduce cytotoxicity
    Hironobu Takahashi
    Department of Materials Physics and Chemistry, Graduate School of Engineering, Kyushu University, Hakozaki, Fukuoka 812 8581, Japan
    Langmuir 22:2-5. 2006
    Hexadecyltrimethylammonium bromide (CTAB), which is necessary for the preparation of gold nanorods (NRs), was extracted from a NR solution into a chloroform phase containing phosphatidylcholine (PC)...
  13. ncbi Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins
    Jwa Min Nam
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201, USA
    Science 301:1884-6. 2003
    ..Comparable clinically accepted conventional assays for detecting the same target have sensitivity limits of approximately 3 picomdar, six orders of magnitude less sensitive than what is observed with this method...
  14. ncbi Oligonucleotide-modified gold nanoparticles for intracellular gene regulation
    Nathaniel L Rosi
    Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3113 USA
    Science 312:1027-30. 2006
    We describe the use of gold nanoparticle-oligonucleotide complexes as intracellular gene regulation agents for the control of protein expression in cells...
  15. pmc Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy
    Jing Lin
    Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA
    ACS Nano 7:5320-9. 2013
    A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment...
  16. pmc Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release
    Jian You
    Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    ACS Nano 4:1033-41. 2010
    We report dual-functional hollow gold nanospheres (HAuNS, approximately 40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation...
  17. doi Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies
    Nikolai Khlebtsov
    Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 13 Pr Entuziastov, Saratov 410049, Russian Federation
    Chem Soc Rev 40:1647-71. 2011
    Recent advances in wet chemical synthesis and biomolecular functionalization of gold nanoparticles have led to a dramatic expansion of their potential biomedical applications, including biosensorics, bioimaging, photothermal therapy, and ..
  18. doi PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography
    Chen Peng
    State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, People s Republic of China
    Biomaterials 33:1107-19. 2012
    We report the synthesis and characterization of dendrimer-entrapped gold nanoparticles (Au DENPs) modified by polyethylene glycol (PEG) with enhanced biocompatibility for computed tomography (CT) imaging applications...
  19. doi Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions
    Alaaldin M Alkilany
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Adv Drug Deliv Rev 64:190-9. 2012
    b>Gold nanorods have promising applications in the fields of drug delivery and photothermal therapy...
  20. doi Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice
    C Lasagna-Reeves
    Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    Biochem Biophys Res Commun 393:649-55. 2010
    b>Gold nanoparticles (GNPs) offer a great promise in biomedicine. Currently, there is no data available regarding the accumulation of nanoparticles in vivo after repeated administration...
  21. doi Cytotoxic effects of gold nanoparticles: a multiparametric study
    Stefaan J Soenen
    Lab of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, B 9000 Ghent, Belgium
    ACS Nano 6:5767-83. 2012
    ....
  22. pmc Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
    Xiao Dong Zhang
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, People s Republic of China
    Int J Nanomedicine 6:2071-81. 2011
    b>Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity...
  23. doi Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant
    Eun Chul Cho
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nano Lett 9:1080-4. 2009
    ..In addition, by fitting the uptake data with a kinetic model, we were able to derive the overall and internalization rate constants for Au nanospheres and both of them were found to be governed by the surface charges on Au nanospheres...
  24. pmc Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin
    Sarah D Brown
    Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, Thomas Graham Building, University of Strathclyde, 295 Cathedral Street, G1 1XL Glasgow, United Kingdom
    J Am Chem Soc 132:4678-84. 2010
    ..In this study, we have tethered the active component of the anticancer drug oxaliplatin to a gold nanoparticle for improved drug delivery...
  25. doi Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
    ..was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...
  26. doi DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
    Anton Kuzyk
    Physik Department and ZNN WSI, Technische Universitat Munchen, Am Coulombwall 4a, 85748 Garching, Germany
    Nature 483:311-4. 2012
    ..In contrast, the optical response of our nanoparticle assemblies is rationally designed and tunable in handedness, colour and intensity-in accordance with our theoretical model...
  27. doi Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats
    Suresh K Balasubramanian
    Division of Environmental Science and Engineering, Department of Anatomy, National University of Singapore, Singapore
    Biomaterials 31:2034-42. 2010
    Biodistribution of gold nanoparticles (AuNPs) in more than 25 organs were examined on 1 day, 1 week, 1 month and 2 months after a single intravenous (i.v.) injection in rats. Au was rapidly and consistently accumulated in liver (49.4+/-50...
  28. doi Effects of cell culture media on the dynamic formation of protein-nanoparticle complexes and influence on the cellular response
    Gabriele Maiorano
    Italian Institute of Technology, Center for Bio Molecular Nanotechnology, Via Barsanti 73010 Arnesano, Lecce, Italy
    ACS Nano 4:7481-91. 2010
    ..In this work, by using citrate-capped gold nanoparticles (AuNPs) of different sizes as a model, we show, by several spectroscopic techniques (dynamic light ..
  29. doi Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods
    Yang Qiu
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, China
    Biomaterials 31:7606-19. 2010
    b>Gold nanorods (Au NRs) have been recognized as promising materials for biomedical applications, like sensing, imaging, gene and drug delivery and therapy, but their toxicological issues are still controversial, especially for the Au NRs ..
  30. doi Gold-catalyzed cycloisomerizations of enynes: a mechanistic perspective
    Eloísa Jiménez-Núñez
    Institute of Chemical Research of Catalonia ICIQ, Av Paisos Catalans 16, 43007 Tarragona, Spain
    Chem Rev 108:3326-50. 2008
  31. ncbi Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 6:662-8. 2006
    We investigated the intracellular uptake of different sized and shaped colloidal gold nanoparticles. We showed that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles (e.g...
  32. ncbi Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview
    Ravi Shukla
    Tissue Engineering and Banking Laboratory, National Centre for Cell Science, Ganeshkhind, Pune, India
    Langmuir 21:10644-54. 2005
    ..In this study, we address the issue of cytotoxicity and immunogenic effects of gold nanoparticles on RAW264.7 macrophage cells...
  33. doi Gold nanoparticles in delivery applications
    Partha Ghosh
    Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA
    Adv Drug Deliv Rev 60:1307-15. 2008
    b>Gold nanoparticles (AuNPs) provide non-toxic carriers for drug and gene delivery applications...
  34. ncbi Gold nanoparticles: a new X-ray contrast agent
    J F Hainfeld
    Nanoprobes, Inc, 95 Horse Block Road, Yaphank, NY 11980, USA
    Br J Radiol 79:248-53. 2006
    ..This report is the first demonstration that gold nanoparticles may overcome these limitations...
  35. doi Uptake and intracellular fate of surface-modified gold nanoparticles
    Paola Nativo
    Department of Chemistry, University of Liverpool, Liverpool, United Kingdom
    ACS Nano 2:1639-44. 2008
    ..Here we report a detailed transmission electron microscopy (TEM) study of the uptake of ca. 16 nm surface-modified gold nanoparticles by human fibroblast cells (HeLa cells)...
  36. pmc Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles
    Partha S Ghosh
    Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA
    ACS Nano 2:2213-8. 2008
    b>Gold colloids functionalized with amino acids provide a scaffold for effective DNA binding with subsequent condensation...
  37. doi In vivo renal clearance, biodistribution, toxicity of gold nanoclusters
    Xiao Dong Zhang
    Institute of Radiation Medicine and Tianjin Key Laboratory of Molecular Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300072, China
    Biomaterials 33:4628-38. 2012
    b>Gold nanoparticles have shown great prospective in cancer diagnosis and therapy, but they can not be metabolized and prefer to accumulate in liver and spleen due to their large size...
  38. pmc Gold nanorods based platforms for light-mediated theranostics
    Zhenjiang Zhang
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
    Theranostics 3:223-38. 2013
    Due to their tunable surface plasmon and photothermal effects, gold nanorods (AuNRs) have proved to be promising in a wide range of biomedical applications such as imaging, hyperthermia therapy and drug delivery...
  39. doi Mediating tumor targeting efficiency of nanoparticles through design
    Steven D Perrault
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, M5S 3E1, Canada
    Nano Lett 9:1909-15. 2009
    ..Our results provide design parameters for engineering nanoparticles for optimized tumor targeting of contrast agents and therapeutics...
  40. doi Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy
    Xiao Dong Zhang
    Institute of Radiation Medicine and Tianjin Key Laboratory of Molecular Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, People s Republic of China
    Biomaterials 33:6408-19. 2012
    b>Gold nanoparticles have been conceived as a radiosensitizer in cancer radiation therapy, but one of the important questions for primary drug screening is what size of gold nanoparticles can optimally enhance radiation effects...
  41. ncbi Plasmonic photothermal therapy (PPTT) using gold nanoparticles
    Xiaohua Huang
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
    Lasers Med Sci 23:217-28. 2008
    ..The synthetic tunability of the optothermal properties and the bio-targeting abilities of the plasmonic gold nanostructures make the PPTT method furthermore promising...
  42. pmc Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages
    - Arnida
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84108, USA
    Eur J Pharm Biopharm 77:417-23. 2011
    Spherical and rod-shaped gold nanoparticles with surface poly(ethylene glycol) (PEG) chains were characterized for size, shape, charge, poly dispersity and surface plasmon resonance...
  43. pmc Gold nanoparticles: a revival in precious metal administration to patients
    A S Thakor
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, California 94305 5427, United States
    Nano Lett 11:4029-36. 2011
    b>Gold has been used as a therapeutic agent to treat a wide variety of rheumatic diseases including psoriatic arthritis, juvenile arthritis, and discoid lupus erythematosus...
  44. doi Effect of gold nanoparticle aggregation on cell uptake and toxicity
    Alexandre Albanese
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, Materials Science and Engineering, University of Toronto, 160 College Street, Toronto, Ontario, Canada
    ACS Nano 5:5478-89. 2011
    ..Here we developed a simple technique to produce transferrin-coated gold nanoparticle aggregates of different sizes and characterized their uptake and toxicity in three different cell ..
  45. pmc The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
    Eun Chul Cho
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nat Nanotechnol 6:385-91. 2011
    ..Here, we use upright and inverted cell culture configurations to show that cellular uptake of gold nanoparticles depends on the sedimentation and diffusion velocities of the nanoparticles and is independent of size,..
  46. pmc Function of mesenchymal stem cells following loading of gold nanotracers
    Laura M Ricles
    Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, Austin, TX, USA
    Int J Nanomedicine 6:407-16. 2011
    ..after delivery via a polyethylene glycol modified fibrin matrix (PEGylated fibrin matrix) using MSCs loaded with gold nanoparticles as nanotracers...
  47. doi Folic acid-conjugated silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy
    Peng Huang
    National Key Laboratory of Nano Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Biomaterials 32:9796-809. 2011
    ..Herein, silica was applied to replace cetyltrimethylammonium bromide (CTAB) molecules on the surface of gold nanorods (GNRs) by the classic Stöber method, thus eliminating their cytotoxicity and improving their ..
  48. ncbi Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles
    Ivan H El-Sayed
    Otolaryngology Head and Neck Surgery, Comprehensive Cancer Center, University of California at San Francisco, CA 94143, USA
    Cancer Lett 239:129-35. 2006
    Efficient conversion of strongly absorbed light by plasmonic gold nanoparticles to heat energy and their easy bioconjugation suggest their use as selective photothermal agents in molecular cancer cell targeting...
  49. pmc Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles
    Ayush Verma
    Department of Materials Science and Engineering, MIT, Massachusetts 02139, USA
    Nat Mater 7:588-95. 2008
    ..Our results offer a paradigm for analysing the fundamental problem of cell-membrane-penetrating bio- and macro-molecules...
  50. doi RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy
    Zhiming Li
    Institute for Laser Medicine and Biophotonics, School of Life Sciences and Biotechnology, and National Key Laboratory of Nano Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
    Mol Pharm 7:94-104. 2010
    ..Although gold nanorods(GNRs) have the potential to perform such a role, the toxicity of surfactant cetyltrimethylammonium ..
  51. ncbi Genetic and functional properties of uncultivated thermophilic crenarchaeotes from a subsurface gold mine as revealed by analysis of genome fragments
    Takuro Nunoura
    Subground Animalcule Retrieval SUGAR Program, Extremebiosphere Research Center, Japan Agency for Marine Earth Science and Technology JAMSTEC, 2 15 Natsushima cho, Jokosuka, Japan
    Environ Microbiol 7:1967-84. 2005
    ..constructed a metagenomic library from a microbial mat formation in a subsurface hot water stream of the Hishikari gold mine, Japan, and sequenced genome fragments of two different phylogroups of uncultivated thermophilic Crenarchaeota:..
  52. ncbi Enhancement of tumor thermal therapy using gold nanoparticle-assisted tumor necrosis factor-alpha delivery
    Rachana K Visaria
    Department of Mechanical Engineering, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Mol Cancer Ther 5:1014-20. 2006
    ..We used a newly developed nanoparticle delivery system consisting of 33-nm polyethylene glycol-coated colloidal gold nanoparticles (PT-cAu-TNF-alpha) with incorporated TNF-alpha payload (several hundred TNF-alpha molecules per ..
  53. doi Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity
    Elodie Boisselier
    Institut des Sciences Moleculaires, UMR CNRS No 5255, Universite Bordeaux I, 33405 Talence Cedex, France
    Chem Soc Rev 38:1759-82. 2009
    ..an overall survey of the basic concepts and up-to-date literature results concerning the very promising use of gold nanoparticles (AuNPs) for medicinal applications...
  54. pmc Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future
    Rochelle R Arvizo
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Chem Soc Rev 41:2943-70. 2012
    ..Noble metal nanoparticles such as gold, silver and platinum are particularly interesting due to their size and shape dependent unique optoelectronic ..
  55. pmc Memecylon edule leaf extract mediated green synthesis of silver and gold nanoparticles
    Tamizhamudu Elavazhagan
    Centre for Interdisciplinary Research, Directorate of Research, SRM University, Kattankulathur, Tamilnadu, India
    Int J Nanomedicine 6:1265-78. 2011
    We used an aqueous leaf extract of Memecylon edule (Melastomataceae) to synthesize silver and gold nanoparticles. To our knowledge, this is the first report where M...
  56. doi Structure-activity relationships in gold nanoparticle dimers and trimers for surface-enhanced Raman spectroscopy
    Kristin L Wustholz
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    J Am Chem Soc 132:10903-10. 2010
    ..This study demonstrates that the creation of hot spots, where two particles are in subnanometer proximity or have coalesced to form crevices, is paramount to achieving maximum SERS enhancements...
  57. pmc Gold nanocages: from synthesis to theranostic applications
    Younan Xia
    Department of Biomedical Engineering, Washington University, Saint Louis, Missouri 63130, USA
    Acc Chem Res 44:914-24. 2011
    b>Gold nanostructures have garnered considerable attention in recent years for their potential to facilitate both the diagnosis and treatment of cancer through their advantageous chemical and physical properties...
  58. ncbi Molecular mechanisms and proposed targets for selected anticancer gold compounds
    Angela Casini
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Curr Top Med Chem 11:2647-60. 2011
    Nowadays, gold compounds constitute a family of very promising experimental agents for cancer treatment...
  59. pmc Multifunctional gold nanostar conjugates for tumor imaging and combined photothermal and chemo-therapy
    Haiyan Chen
    1 Department of Biomedical Engineering, State Key Laboratory of Natural Medicines and School of Life Science and Technology, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China
    Theranostics 3:633-49. 2013
    Uniform gold nanostars (Au NS) were conjugated with cyclic RGD (cRGD) and near infrared (NIR) fluorescence probe (MPA) or anti-cancer drug (DOX) to obtain multi-functional nanoconstructs, Au-cRGD-MPA and Au-cRGD-DOX respectively...
  60. doi Gold nanoparticles in biomedical applications: recent advances and perspectives
    Lev Dykman
    Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 13 Pr Entuziastov, Saratov 410049, Russian Federation
    Chem Soc Rev 41:2256-82. 2012
    b>Gold nanoparticles (GNPs) with controlled geometrical, optical, and surface chemical properties are the subject of intensive studies and applications in biology and medicine...
  61. ncbi PEG-modified gold nanorods with a stealth character for in vivo applications
    Takuro Niidome
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi ku, Fukuoka 819 0395, Japan
    J Control Release 114:343-7. 2006
    b>Gold nanorods prepared in hexadecyltrimethylammonium bromide (CTAB) solution are expected to provide novel materials for photothermal therapy and photo-controlled drug delivery systems...
  62. doi Size-dependent toxicity and cell interaction mechanisms of gold nanoparticles on mouse fibroblasts
    Rosella Coradeghini
    Nanobiosciences Unit, Joint Research Centre, Institute for Health and Consumer Protection, European Commission, Via E Fermi 2749, 21027 Ispra, VA, Italy
    Toxicol Lett 217:205-16. 2013
    b>Gold nanoparticles (AuNPs) are currently used in several fields including biomedical applications, although no conclusive information on their cytotoxicity is available...
  63. pmc Analytical and theranostic applications of gold nanoparticles and multifunctional nanocomposites
    Nikolai Khlebtsov
    Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences IBPPM RAS, Russian Federation
    Theranostics 3:167-80. 2013
    b>Gold nanoparticles (GNPs) and GNP-based multifunctional nanocomposites are the subject of intensive studies and biomedical applications...
  64. doi A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity
    Helinor J Johnston
    Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Edinburgh, UK
    Crit Rev Toxicol 40:328-46. 2010
    This review is concerned with evaluating the toxicity associated with human exposure to silver and gold nanoparticles (NPs), due to the relative abundance of toxicity data available for these particles, when compared to other metal ..
  65. doi Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of pro-inflammatory mediators
    Qin Zhang
    Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA
    Nanotoxicology 5:284-95. 2011
    ..The localization of Au NPs in intracellular vacuoles suggests endosomal containment and an uptake mechanism involving endocytosis...
  66. pmc Photoacoustic imaging of mesenchymal stem cells in living mice via silica-coated gold nanorods
    Jesse V Jokerst
    Molecular Imaging Program at Stanford, Department of Radiology, 318 Campus Drive, Stanford University, Stanford, California 94305 5427, United States
    ACS Nano 6:5920-30. 2012
    ..Here, we report the use of silica-coated gold nanorods as a contrast agent for photoacoustic imaging and quantitation of mesenchymal stem cells in rodent muscle ..
  67. doi Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos
    Ofek Bar-Ilan
    Division of Pharmaceutical Sciences, University of Wisconsin Madison, 777 Highland Ave, Madison, WI 53705 2222, USA
    Small 5:1897-910. 2009
    ..Using colloidal silver (cAg) and gold nanoparticles (cAu) in a panoply of sizes (3, 10, 50, and 100 nm) and a semiquantitative scoring system, it is ..
  68. doi Plasmonic gold nanocrystals coupled with photonic crystal seamlessly on TiO2 nanotube photoelectrodes for efficient visible light photoelectrochemical water splitting
    Zhonghai Zhang
    Water Desalination and Reuse Center, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955 6900, Saudi Arabia
    Nano Lett 13:14-20. 2013
    ..This work contributes to the rational design of the visible light responsive plasmonic photocatalytic composite material based on wide band gap metal oxides for photoelectrochemical applications...
  69. doi Aptamer-based colorimetric biosensing of Ochratoxin A using unmodified gold nanoparticles indicator
    Cheng Yang
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China
    Biosens Bioelectron 26:2724-7. 2011
    This work presents an aptasensor for Ochratoxin A (OTA) using unmodified gold nanoparticles (AuNPs) indicator...
  70. doi Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats
    Daniëlle Pk Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Nanomedicine (Lond) 6:339-49. 2011
    To develop and determine the safety of gold nanorods, whose aspect ratios can be tuned to obtain plasmon peaks between 650 and 850 nm, as contrast enhancing agents for diagnostic and therapeutic applications.
  71. doi pH-Induced aggregation of gold nanoparticles for photothermal cancer therapy
    Jutaek Nam
    Department of Chemistry, Pohang University of Science and Technology, San 31, Hyojadong, Namgu, Pohang 790 784, South Korea
    J Am Chem Soc 131:13639-45. 2009
    We report a "smart" gold nanoparticle that is designed to aggregate in mild acidic intracellular environments by its hydrolysis-susceptible citraconic amide surface...
  72. doi A new era for cancer treatment: gold-nanoparticle-mediated thermal therapies
    Laura C Kennedy
    William Marsh Rice University, Dept of Bioengineering MS 142, 6100 Main St, Houston, TX 77005 1892, USA
    Small 7:169-83. 2011
    ..b>Gold-nanoparticle-mediated hyperthermia shows particular promise in animal studies, and early clinical testing is ..
  73. pmc Gold nanoparticles as novel agents for cancer therapy
    S Jain
    Northern Ireland Cancer Centre, Queens University Belfast, Belfast, UK
    Br J Radiol 85:101-13. 2012
    b>Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers...
  74. doi Disposable biosensor based on graphene oxide conjugated with tyrosinase assembled gold nanoparticles
    Wei Song
    Shanghai Key Laboratory of Functional Materials Chemistry and Department of Chemistry, East China University of Science and Technology, Shanghai, China
    Biosens Bioelectron 26:3181-6. 2011
    ..acid, succinimidyl ester (PASE) adsorbing on the graphene oxide (GO) sheets and amines of tyrosinase-protected gold nanoparticles (Tyr-Au). Herein, the bi-functional molecule PASE was assembled onto GO sheets...
  75. ncbi Nanoshell-enabled photonics-based imaging and therapy of cancer
    Christopher Loo
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77030, USA
    Technol Cancer Res Treat 3:33-40. 2004
    ..spherical nanoparticle consisting of a dielectric core covered by a thin metallic shell which is typically gold. Nanoshells possess highly favorable optical and chemical properties for biomedical imaging and therapeutic ..
  76. doi Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects
    Alaaldin M Alkilany
    Department of Chemistry and Biochemistry University of South Carolina Columbia, SC 29208, USA
    Small 5:701-8. 2009
    b>Gold nanorods of different aspect ratios are prepared using the growth-directing surfactant, cetyltrimethylammonium bromide (CTAB), which forms a bilayer on the gold nanorod surface...
  77. ncbi Single-mismatch detection using gold-quenched fluorescent oligonucleotides
    B Dubertret
    Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Nat Biotechnol 19:365-70. 2001
    Here we describe a hybrid material composed of a single-stranded DNA (ssDNA) molecule, a 1.4 nm diameter gold nanoparticle, and a fluorophore that is highly quenched by the nanoparticle through a distance-dependent process...
  78. pmc Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles
    Chung Hang J Choi
    Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:1235-40. 2010
    PEGylated gold nanoparticles are decorated with various amounts of human transferrin (Tf) to give a series of Tf-targeted particles with near-constant size and electrokinetic potential...
  79. doi Autophagy and oxidative stress associated with gold nanoparticles
    Jasmine J Li
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Biomaterials 31:5996-6003. 2010
    ..Yet for gold nanoparticles (AuNPs), it is not well established whether these particles are biologically toxic...
  80. pmc Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells
    Jingyi Chen
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Nano Lett 7:1318-22. 2007
    b>Gold nanocages with a relatively small size (e.g...
  81. doi Gold nanorod-photosensitizer complex for near-infrared fluorescence imaging and photodynamic/photothermal therapy in vivo
    Boseung Jang
    Molecular Imaging and Therapy Branch, National Cancer Center, 111 Jungbalsan ro, Ilsandong gu, Goyang, Gyeonggi do 410 769, South Korea
    ACS Nano 5:1086-94. 2011
    A gold nanorod (GNR)-photosensitizer complex was developed for noninvasive near-infrared fluorescence imaging and cancer therapy...
  82. doi Gold and platinum catalysis--a convenient tool for generating molecular complexity
    Alois Fürstner
    Max Planck Institut fur Kohlenforschung, D 45470 Mulheim Ruhr, Germany
    Chem Soc Rev 38:3208-21. 2009
    ..the reader with the essence of pi-acid catalysis, in particular with reactions or reaction cascades effected by gold and platinum complexes...
  83. doi Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage
    Yu Pan
    Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University, Aachen, Germany
    Small 5:2067-76. 2009
    b>Gold nanoparticles (AuNPs) are generally considered nontoxic, similar to bulk gold, which is inert and biocompatible. AuNPs of diameter 1.4 nm capped with triphenylphosphine monosulfonate (TPPMS), Au1...
  84. pmc Tuning payload delivery in tumour cylindroids using gold nanoparticles
    Byoungjin Kim
    Department of Chemical Engineering, University of Massachusetts, Amherst, Massachusetts 01003 9303, USA
    Nat Nanotechnol 5:465-72. 2010
    ..Here, we show that gold nanoparticles carrying either fluorescein or doxorubicin molecules move and localize differently in an in vitro ..
  85. pmc Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects
    Ling Tong
    Department of Chemistry, Purdue University, West Lafayette, IN, USA
    Photochem Photobiol 85:21-32. 2009
    b>Gold nanorods (NRs) have plasmon-resonant absorption and scattering in the near-infrared (NIR) region, making them attractive probes for in vitro and in vivo imaging...
  86. ncbi Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
    D Patrick O'Neal
    Nanospectra Biosciences, Inc, 8285 El Rio Suite 130, Houston, TX 77054, USA
    Cancer Lett 209:171-6. 2004
    ..This technique takes advantage of the strong near infrared (NIR) absorption of nanoshells, a new class of gold nanoparticles with tunable optical absorptivities that can undergo passive extravasation from the abnormal tumor ..
  87. doi Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos
    P V AshaRani
    Department of Chemistry, National University of Singapore, Singapore
    Nanotoxicology 5:43-54. 2011
    ..Toxicity assays of silver, gold, and platinum nanoparticles, using zebrafish embryos to study their developmental effects were carried out...
  88. ncbi Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy
    Xiaohua Huang
    Georgia Institute of Technology, Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA
    Nanomedicine (Lond) 2:681-93. 2007
    ..In this review, we outline the surface-plasmon resonance-enhanced optical properties of colloidal gold nanoparticles directed towards recent biomedical applications with an emphasis on cancer diagnostics and ..
  89. pmc Ligand effects in homogeneous Au catalysis
    David J Gorin
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Chem Rev 108:3351-78. 2008
  90. ncbi Selective laser nano-thermolysis of human leukemia cells with microbubbles generated around clusters of gold nanoparticles
    Dmitri O Lapotko
    Luikov Heat and Mass Transfer Institute, Minsk, 220072, Belarus
    Lasers Surg Med 38:631-42. 2006
    ..The objective of this study was two-fold: to optimize NP targeting to real tumor (human) cells and to better understand physical mechanisms of cell damage for improved control of the laser ablation...
  91. pmc A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands
    Xiaohua Huang
    Department of Biomedical Engineering, Emory University, 101 Woodruff Circle Suite 2007, Atlanta, Georgia 30322, United States
    ACS Nano 4:5887-96. 2010
    ..Here we report quantitative tumor uptake studies for a class of elongated gold nanocrystals (called nanorods) that are covalently conjugated to tumor-targeting peptides...
  92. pmc Archaeal diversity in waters from deep South African gold mines
    K Takai
    Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Appl Environ Microbiol 67:5750-60. 2001
    A culture-independent molecular analysis of archaeal communities in waters collected from deep South African gold mines was performed by performing a PCR-mediated terminal restriction fragment length polymorphism (T-RFLP) analysis of rRNA ..
  93. ncbi Synergistic enhancement of selective nanophotothermolysis with gold nanoclusters: potential for cancer therapy
    Vladimir P Zharov
    Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Lasers Surg Med 37:219-26. 2005
    ..We developed a new approach that enhances selective photothermolysis of tumor through laser activation of synergistic phenomena around nanoclusters, which are self-assembled into cancer cells...
  94. ncbi Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract
    S Prathap Chandran
    Nanoscience Group, Materials Chemistry Division, Biochemical Sciences Division, National Chemical Laboratory, Pune 411008, India
    Biotechnol Prog 22:577-83. 2006
    Biogenic gold nanotriangles and spherical silver nanoparticles were synthesized by a simple procedure using Aloe vera leaf extract as the reducing agent...
  95. doi Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold miners
    Jill Murray
    National Institute for Occupational Health, PO Box 4788, Johannesburg2000, South Africa
    AIDS 21:S97-S104. 2007
    ..To describe causes of death and respiratory infections in HIV-infected miners in the pre-antiretroviral era, by duration of HIV infection...
  96. pmc On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases
    Fulvio Saccoccia
    Department of Biochemical Sciences A Rossi Fanelli, Sapienza University of Rome, Rome, Italy
    J Inorg Biochem 108:105-11. 2012
    ..Auranofin (AF), a gold-containing compound, is classified by the World Health Organization as an antirheumatic agent and it is indicated ..
  97. doi Enhanced photocurrent generation by photosynthetic bacterial reaction centers through molecular relays, light-harvesting complexes, and direct protein-gold interactions
    Mart Jan den Hollander
    Biophysics, Faculty of Mathematics and Natural Sciences, Leiden University, P O Box 9502, 2300RA Leiden, The Netherlands
    Langmuir 27:10282-94. 2011
    ..The possibility of adhering RCs to a bare gold electrode was investigated with a view to minimizing the distance for electron tunneling between the protein-..
  98. doi Applications of vectorized gold nanoparticles to the diagnosis and therapy of cancer
    Audrey Llevot
    ENSCPB, Universite Bordeaux 1, 33607 Pessac, France
    Chem Soc Rev 41:242-57. 2012
    This critical review focuses on the anti-cancer fight using gold nanoparticles (AuNPs) functionalized with chemotherapeutic drugs in so-called "complexes" (supramolecular assemblies) and "conjugates" (covalent assemblies) as vectors...
  99. doi Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment
    Zhenjiang Zhang
    CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Adv Mater 24:1418-23. 2012
    Mesoporous silica-coated gold nanorods (Au@SiO(2)) are developed as a promising and versatile theranostic platform for cancer treatment. Intracellular localization of Au@SiO(2) is visualized through two-photon imaging...
  100. doi Gold nanoparticles in biology: beyond toxicity to cellular imaging
    Catherine J Murphy
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA
    Acc Chem Res 41:1721-30. 2008
    b>Gold, enigmatically represented by the target-like design of its ancient alchemical symbol, has been considered a mystical material of great value for centuries...
  101. pmc Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas
    Geoffrey von Maltzahn
    Division of Health Sciences and Technology, Harvard Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 69:3892-900. 2009
    ..We synthesized polyethylene glycol (PEG)-protected gold nanorods (NR) that exhibit superior spectral bandwidth, photothermal heat generation per gram of gold, and ..

Research Grants81

  1. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..We did not have any success generating transgenic lines directly in the C57Black6 strain. C57Black6 mice are the gold-standard for the types of metabolic experiments proposed. Cold-exposure...
  2. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..In addition, the insulin tolerance test (ITT), which is generally considered the gold standard test for both GHD and sAI, requires intensive medical supervision and is contraindicated in cases of head ..
  3. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..These MagMOONs are micron sized tracer particles with one hemisphere coated by gold creating an orientation-dependent scattering and fluorescence signal...
  4. Improving TB Diagnosis in Children with and without HIV in Kenya
    Rinn Song; Fiscal Year: 2013
    ..Pediatric TB has no sensitive and specific "gold standard" diagnostic method...
  5. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..CRC is the only cancer for which the diagnostic test colonoscopy, considered to be the gold standard, is recommended as a screening test (14.15)...
  6. Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic Acids
    TIMOTHY L SITA; Fiscal Year: 2013
    ..We will utilize small interfering RNA (siRNA) duplexes densely conjugated to the surface of gold nanoparticles (MGMTi-Spherical Nucleic Acids (SNAs))...
  7. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..Surgical endoscopy has remained the gold standard in the diagnosis of SGS...
  8. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..Many of these conditions have been linked to dysfunctional 5HT neurochemistry. L-DOPA is the gold-standard pharmacotherapy for PD...
  9. Dual-Receptor Targeted Nanoparticles for Photodynamic Therapy of Brain Cancer
    Ann Marie Broome; Fiscal Year: 2013
    ..The objective of the proposed research is to develop Pc 4 loaded gold nanoparticle (Au NP-Pc 4) conjugates with a thiolated PEG coating for targeted imaging-guided therapy of glioma ..
  10. SYSTEM FOR AUTOMATED NONINVASIVE MONITORING OF MOUSE SLEEP AND BEHAVIOR
    Sridhar Sunderam; Fiscal Year: 2013
    ..The current gold standard for sleep analysis in mammals is electroencephalography (EEG) with electromyography (EMG)...
  11. Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT
    Jun Zhang; Fiscal Year: 2013
    ..The current gold standard diagnostic modality, overnight polysomnography is inconvenient, unable to provide information on upper ..
  12. Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..units, pulmonary capillary wedge pressure [PCWP] <18 mm Hg) due to chronic obstructive pulmonary disease (COPD) GOLD stage II or higher, FEV1/FVC <70 and FEV1 <79% of predicted)...
  13. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..by a reduction in the mean arthritic score that is equivalent or superior to the treatment effect elicited by the gold-standard clinically-approved agent etanercept...
  14. Long-Acting G-CSF Analog for Treating ARS
    GEORGE NORBERT COX; Fiscal Year: 2013
    ..we will determine whether the protein improves survival of lethally-irradiated non-human primates, which is the gold standard ARS model adopted by the FDA...
  15. Masked Hypertension in Chronic Kidney Disease
    Rajiv Agarwal; Fiscal Year: 2013
    ..Body composition will be measured by the gold-standard measurement of air-displacement plethysmography (Bod Pod)...
  16. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    Sharon E Murphy; Fiscal Year: 2010
    ..Dried blood spots have been called a "gold mine" for assessing toxic exposures...
  17. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..They also have known toxicities post degradation. Gold nanoparticles (AuNPs), on the other hand, have three advantages: potential lymph drainage due to their small size, ..
  18. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..peptides can be used for cell specific diagnostic imaging using molecular nanoplatforms with phage-nanogold or nano-gold peptide devices. Specific Aim 1 will define endothelial cell ligand/receptor pairs associated with SPH...
  19. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly J Henrickson; Fiscal Year: 2010
    ..the clinical sensitivity and specificity of the newly developed assays, compared to non-molecular methods and our "gold standard" not integrated molecular assays (PCR-EHA) on 1200 previously collected samples...
  20. Gross Hall Animal Resource Center
    Susan V Bryant; Fiscal Year: 2010
    ..is a leader in constructing and operating green buildings, with three recent campus building projects already LEED "Gold" certified, including the first gold certification in Orange County...
  21. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..It has become the gold standard for characterizing reproductive aging, as the Tanner Stages characterize puberty...
  22. Human hepatocytes for drug toxicity screening from Cardiac Death Donor livers
    Mark G Clemens; Fiscal Year: 2012
    ..many species differences between humans and commonly used animal models, testing on human hepatocytes remains the gold standard for drug screening...
  23. Planning Grant for the Efficacy of Auranofin for the Treatment of Amebiasis
    Sharon L Reed; Fiscal Year: 2012
    ..By screening all FDA approved drugs against E. histolytica trophozoites, we found one drug, auranofin, an oral gold-containing compound approved in 1985 to treat rheumatoid arthritis, had an IC50 of 0...
  24. Assessment of Dehydration in Children with Diarrhea in Resource-Limited Settings
    ADAM CARL LEVINE; Fiscal Year: 2013
    ..for determining the severity of dehydration in children, this scale has never been validated against a physiologic gold standard (such as the accepted standard of percent weight change with rehydration)...
  25. Autophagy and human islet amyloid polypeptide in animal models of type 2 diabetes
    Jacqueline Rivera; Fiscal Year: 2013
    ..e. LC3II, p62, and Atg7) and use of the gold standard in the field, electron microscopy...
  26. NOVEL HIGH THROUGHPUT PLATFORM FOR SCREENING CYTOCHROME P450 INDUCTION
    MARIA INES MORANO; Fiscal Year: 2013
    ..Enzymatic activity in freshly isolated hepatocytes is the "Gold Standard" for studying P450 induction;however, its application is hindered by variation among donors and limited ..
  27. Foot Bone Motion in End Stage Ankle Arthritis Patients
    William R Ledoux; Fiscal Year: 2012
    ..Until fairly recently, the "gold standard" for treatment ESAA has been an ankle arthrodesis (i.e., a fusion)...
  28. Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic Test
    CHRISTOPHER GERARD COONEY; Fiscal Year: 2012
    ..Because of its sensitivity and specificity, molecular testing are beginning to supplant conventional culture as the gold standard...
  29. The Unfolded Protein Response in Human Airway and Alveolar Epithelial Cells
    Salim Merali; Fiscal Year: 2010
    ..Cells will be harvested from ex-- smokers without COPD (n=10) and ex-smokers with COPD in GOLD stages II (n=10) and IV (n=10) using the technique of laser capture microscopy applied to HOPE fixed, inflated lung ..
  30. Tb-FISH (Fluorescent in Situ Hybridization) Assay for Direct Detection of M. tube
    JYOTSNA S SHAH; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Culture is the gold standard. Unfortunately it can take anywhere from one week to 2 months...
  31. RCT of US versus CT for Patients in the ED with Suspected Renal Colic
    Rebecca Smith Bindman; Fiscal Year: 2010
    ..introduced as an alternative to ultrasonography in 1995, and in the United States has been rapidly embraced as the gold standard for diagnostic imaging in patients with suspected urolithiasis...
  32. Homing of Stem Cells in Stroke Therapeutics
    EVAN YALE contact SNYDER; Fiscal Year: 2010
    ..Neuroectoderm-derived stem cells ("neural stem cells [NSCs]") have been the "gold-standard" for such therapeutics against which any alternative stem cell type must be compared...
  33. Genetic and Cellular Basis of Resistance/Sensitivity to Myocardial Ischemia
    Howard J Jacob; Fiscal Year: 2012
    ..3. Functional validation of the gene(s) responsible for the resistance to ischemia. The gold standard for proving that a gene is causal requires some form of rescue experiment...
  34. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine A Curcio; Fiscal Year: 2012
    ..We will exploit a unique resource of human donor eyes at different stages of ARM to produce gold standards for retinal image interpretation...
  35. Molecular mechanism of antiangiogenic properties of gold nanoparticle
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..g. gold nanoparticles (AuNPs) have wine red color, whereas metallic gold is golden yellow and this wine red color can be ..
  36. Calcium wave propagation along microvascular endothelial tubes
    MATTHEW JOHN SOCHA; Fiscal Year: 2012
    ..When delivered to a discrete site on an arteriole or FA, acetylcholine (ACh;the "gold standard" endothelium-dependent vasodilator) initiates a Ca+2 wave that travels from EC to EC for hundreds of ..
  37. Intra-operative confocal imaging to guide Mohs surgery
    Milind Rajadhyaksha; Fiscal Year: 2012
    ..Sensitivity and specificity will be determined, against the gold standard of Mohs frozen pathology, to validate the feasibility of the technology...
  38. Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cells
    Paul R Knight; Fiscal Year: 2010
    ..e., Gold Nanorods, GNR) and anionic genetic material (i.e., cDNA or siRNA)...
  39. Prevalence of DSM-IV Disorders in an Multi-Center HIV+ Women's Cohort
    Judith A Cook; Fiscal Year: 2013
    ..The purpose of this study is to administer to the WIHS cohort the gold standard in structured diagnostic interviews for behavioral health epidemiology, the World Mental Health-Composite ..
  40. Skeletal muscle function and mitochondrial metabolism in non-diabetic CKD
    Baback Roshanravan; Fiscal Year: 2012
    ..between skeletal muscle dysfunction and insulin resistance among persons with chronic kidney disease using gold-standard euglycemic clamp testing...
  41. Phenotypes of diabetic kidney disease and the relationship to retinal pathology
    Amy Mottl; Fiscal Year: 2013
    ..component of the proposed research consists of a preliminary study to determine the feasibility of performing the gold standards of kidney biopsy, iohexol GFR measurement and retinal photography on type 2 diabetic participants...
  42. Neurotoxicity of Magnetic Nanoparticles
    Veronica Shubayev; Fiscal Year: 2010
    ..Emphasis will be made on studying the role of surface chemistry (DMSA, dextran and gold) on activating oxidative stress signaling and biodistribution in vitro and in vivo...
  43. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..The "gold standard" test for the assessment of allograft rejection is renal allograft biopsy, which is an invasive, expensive ..
  44. Rapid Heart Attack Detection using an AC Electrokinetic Device
    Rajaram Krishnan; Fiscal Year: 2011
    ..2 - Use prototype ACE device to characterize performance for MI plasma and compare against gold standards (QIAamp kit for CFC-DNA, FACS for EMPs)...
  45. Orexin Receptor Agonists for the Treatment of Excessive Daytime Sleepiness and Ca
    PAUL STUART HUMPHRIES; Fiscal Year: 2013
    ..Because of this, Reset anticipates that orexin receptor agonists could become the gold standard in narcolepsy treatment, due to the accepted cause of the disorder in humans...
  46. Treatment Implications of Trauma Memory Modulation for PTSD & Alcohol Dependence
    Michael E Saladin; Fiscal Year: 2010
    ..define the optimal parameters under which propranolol could be used in prolonged exposure therapy (PTSD treatment gold standard) to enhance reduction of both PTSD-related anxiety and drinking...
  47. Low Cost Diagnosis of Disease using Synthetic DNA Reactions
    William L Hughes; Fiscal Year: 2013
    ..Based on relative miRNA concentrations, gold nanoparticle aggregation will signify a positive/negative signal for disease, analogous to the results of a ..
  48. International Training and Research in Environmental and Occupational Health
    NELSON K STEENLAND; Fiscal Year: 2012
    ..Two other Peruvian Fogarty studies funded via Emory showed a similar situation with informal gold miners using mercury and nurses using cytostatic drugs...
  49. Insulin Resistance in Chronic Kidney Disease
    Ian H De Boer; Fiscal Year: 2013
    ..of the pancreatic beta cell, and net effects on glucose tolerance, which are currently poorly understood, using gold standard methods (hyperinsulinemic euglycemic clamp, intravenous glucose tolerance test, oral glucose tolerance ..
  50. Placental shape features, gestational timing and maternal and infant health
    Carolyn M Salafia; Fiscal Year: 2011
    ..g. fetoplacental weight ratio) and have not reported consistent findings. The current "gold standard" measures of placental shape include dichotomous descriptions of placenta shape (as "round"/oval" and "..
  51. TERPENE CONDENSATION REACTIONS
    CHARLES POULTER; Fiscal Year: 2009
    ..We are developing reagents and protocols for regio- and chemoselective attachment of proteins to silica and gold surfaces that permit us to attach natively folded proteins in a manner that preserves their function...
  52. A new experimental model of knee joint trauma
    TAMMY L HAUTDONAHUE; Fiscal Year: 2012
    ..revolutionize the understanding of traumatic joint injury that leads to a post-traumatic OA by greatly altering the gold standard model used to study the pathology of knee OA...
  53. Biomarkers of Kidney Pathology
    Sushrut S Waikar; Fiscal Year: 2013
    ..prospective cohort study involving biological sample collection from patients undergoing native kidney biopsy, the gold standard determination for identifying the cause(s) of CKD...
  54. Advanced Immunocytochemistry, In Situ Hybridization and Live Cell Imaging Course
    TERRI I GRODZICKER; Fiscal Year: 2013
    ..performing experiments using different antigen-antibody systems (fluorescence, enzymatic, colloidal gold), and employing GFP-fusion proteins to localize, quantify, and analyze proteins in living cells using standard ..
  55. Dual Modality System for Imaging Colon Cancer in Mice
    Jennifer Kehlet Barton; Fiscal Year: 2013
    ..We will continue to develop targeted contrast agents, focusing on the targets VEGFR and EGFR. Gold nanoparticles will be used as OCT reporters...
  56. Measurement of Renal Viscoelastic Properties with Ultrasound
    MATTHEW WILLIAM URBAN; Fiscal Year: 2013
    ..Renal biopsy is the gold standard for diagnosis of kidney health, but is an invasive procedure, can not be used frequently, and can cause ..
  57. Polyvalent siRNA-Gold Nanoparticle Constructs to Eradicate Glioma
    Emily S Day; Fiscal Year: 2012
    ..The proposed work seeks to overcome these limitations by densely loading siRNA onto gold nanoparticles, thereby protecting it from RNase degradation and enabling it to cross the blood-brain barrier and ..
  58. Targeted delivery of osteoinductive molecules to biologic HA in bone grafts
    Jennifer L Bain; Fiscal Year: 2012
    ..Autogenous bone is widely used as the gold standard in craniofacial regenerative medicine, but comes with increased morbidity to the patient (3)...
  59. Rapid, Low-Cost Cell-Sorting System for Diagnosis of Candidemia
    Scott Irwin; Fiscal Year: 2010
    ..Existing fungal detection methods are slow. Culture is the gold-standard, but this often takes up to 72 hours...
  60. Towards Measures of Lupus Nephritis Activity &Damage for Children
    Hermine I Brunner; Fiscal Year: 2012
    ..Despite remaining the "gold standard" for diagnosing LN, kidney biopsies are impractical to assess the course of LN given their invasiveness ..
  61. Improved Source Localization for Pediatric Epilepsy
    Damon Hyde; Fiscal Year: 2013
    ..near term, I seek to demonstrate that these techniques can offer a non- invasive approach to the current clinical gold standard of electrocorticography...
  62. The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
    ROBERT STANLEY SHERWIN; Fiscal Year: 2012
    ..Human work will both validate the [11C]MRB PET strategy against the current gold standard of [18F]FDG labeling, using both room temperature and mild cold exposure, as well as provide a preliminary ..
  63. Preventing Burn Wound Infection Using a Novel Free Radical Sterilization System
    BENJAMIN DAVID SADOWITZ; Fiscal Year: 2011
    ..SuperPulse PPT free radical system is equally efficacious at preventing burn wound infection in this model as the "gold standard" topical antimicrobial Silvadene...
  64. Anti-fibrotic Coatings for Rapidly Exchangeable Bioprosthetic Heart Valve
    Ivan Vesely; Fiscal Year: 2010
    ..A control group will make use of the gold standard Edwards pericardial valve...
  65. Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
    Scott E Fraser; Fiscal Year: 2010
    ..provided by applicant): Since its first use in the retina in 1961, fluorescein angiography (FA) has been the gold standard for objective characterization of retinovascular disease (e.g...
  66. Integrated Multifunctional Imaging of Deep Vein Thrombosis
    Walter Scott; Fiscal Year: 2009
    ..However, there are no reliable, clinically available methods to stage DVT. Even the gold standard diagnostic technique, duplex venous ultrasound, can only detect but not age these clots...
  67. Translating COPD Guidelines inot Primary Care Practice
    Donna Parker; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): This project will evaluate the translation of the Gold (the Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease) COPD guidelines into primary care ..
  68. Rapid Point-of-Care Test Kit for the Detection of Bacteriuria Calibrated for Imme
    MARK GEISBERG; Fiscal Year: 2010
    ..While bacteriuria at a level of 105 CFU/ml is the gold standard for UTI diagnosis, in practice the required urine culture is unfeasible due to the typical 2-day delay in ..
  69. Evaluating BMY-14802 as an anti-dyskinesia treatment in the 6-OHDA rat model of P
    MELANIE PAQUETTE; Fiscal Year: 2009
    ..L-DOPA is the gold standard of treatment for Parkinson's, but unfortunately, the majority of people who take L-DOPA eventually ..
  70. Controlled Release Vascular Grafts
    ANTONIO WEBB; Fiscal Year: 2009
    ..Although native vessels remain the gold standard conduit for bypass grafting, they are not available in approximately one-third of patients due to ..
  71. Decoy receptor 3 and liver cirrhosis
    Sunghee Kim; Fiscal Year: 2006
    ..Currently, liver biopsy is the gold standard in determining the presence of liver cirrhosis...
  72. Placental Pathology: Digital Assessment and Validation
    Carolyn Salafia; Fiscal Year: 2009
    ..Unfortunately, current diagnostic pathology "gold standards" are neither reliable nor have they been validated against measures other than "group consensus", a poor ..
  73. Hybrid Nanoparticles in Imaging and Therapy of Prostate*
    Kattesh Katti; Fiscal Year: 2009
    ..Our CNP's overarching goal focuses on developing hybrid gold nanoparticle-based molecular imaging agents and targeted therapeutic agents that are effective in the diagnosis and ..
  74. 2/3 CBT for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
    Eric A Storch; Fiscal Year: 2010
    ..While cognitive-behavioral therapy (CBT) has been established as the gold standard treatment for anxiety disorders among typically developing youth, and innovative work by the investigative ..
  75. 3/3 CBT for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
    JILL EHRENREICH MAY; Fiscal Year: 2010
    ..While cognitive-behavioral therapy (CBT) has been established as the gold standard treatment for anxiety disorders among typically developing youth, and innovative work by the investigative ..
  76. Depth Maps From Stereo Images of the Optic Disc-Phase II
    GILBERTO ZAMORA; Fiscal Year: 2006
    ..The current gold standard for measuring these changes is through clinical stereoscopic observation of the ONH...
  77. A Video DVD Program to Assist with Informed Consent
    Neil Love; Fiscal Year: 2004
    Randomized controlled clinical trials are universally viewed as the gold standard for evidence-based medicine and the most powerful tool available to evaluate interventions for possible incorporation into clinical practice...
  78. GLUTATHIONE PEROXIDASE ACTION AND INHIBITION
    PETER GETTINS; Fiscal Year: 1990
    ..There is evidence to link some of the most effective drugs used in treatment of rheumatoid arthritis, including the gold drugs, with potent inhibition of glutathione peroxidase...
  79. Detection of Category A Pathogens by Gold Nanoparticles
    Steven Wolinsky; Fiscal Year: 2007
    ..anthracis by exploiting the unique properties of DNA-gold nanoparticle conjugates...
  80. Colon Polyp Surveillance with DNA Analysis of Stool
    Philip Schoenfeld; Fiscal Year: 2003
    ..If this non-invasive test truly mimics the accuracy of the gold-standard test, surveillance colonoscopy, then fecal MTAP may offer a safer and more economical approach to colon ..
  81. Bioactive Peptide Coatings for Synthetic Bone Grafts in Dental Applications
    HANNE GRON; Fiscal Year: 2007
    ..Autograft bone is considered the gold standard because of its osteogenic cells, osteoinductive factors, and osteoconductive properties...