gallium

Summary

Summary: A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.

Top Publications

  1. ncbi Single gallium nitride nanowire lasers
    Justin C Johnson
    Department of Chemistry, University of California, Berkeley, California 94720 1460, USA
    Nat Mater 1:106-10. 2002
  2. ncbi Second harmonic generation in gallium phosphide photonic crystal nanocavities with ultralow continuous wave pump power
    Kelley Rivoire
    E L Ginzton Laboratory, Stanford University, Stanford, CA 94305 4085, USA
    Opt Express 17:22609-15. 2009
  3. ncbi Gallium poisoning: a rare case report
    Chris S Ivanoff
    College of Dentistry, The University of Tennessee Health Science Center, 875 Union Avenue, Memphis, TN 38163, USA
    Food Chem Toxicol 50:212-5. 2012
  4. ncbi Effect of gallium arsenide diode laser on human periodontal disease: a microbiological and clinical study
    Selcuk Yilmaz
    Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul, Turkey
    Lasers Surg Med 30:60-6. 2002
  5. ncbi Surfactant-free, large-scale, solution-liquid-solid growth of gallium phosphide nanowires and their use for visible-light-driven hydrogen production from water reduction
    Jianwei Sun
    Joint Center for Artificial Photosynthesis JCAP, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Am Chem Soc 133:19306-9. 2011
  6. ncbi Combined administration of oxalic acid, succimer and its analogue for the reversal of gallium arsenide-induced oxidative stress in rats
    Swaran J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Arch Toxicol 76:269-76. 2002
  7. pmc The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent
    Ehud Banin
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:16761-6. 2008
  8. ncbi Comparison of 18F-FDG and 68Ga PET imaging in the assessment of experimental osteomyelitis due to Staphylococcus aureus
    Tatu J Makinen
    Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, University of Turku, Turku, Finland
    Eur J Nucl Med Mol Imaging 32:1259-68. 2005
  9. ncbi Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium
    Jakub Simeček
    Department of Inorganic Chemistry, Univerzita Karlova Charles University, Hlavova 2030, 12843 Prague 2, Czech Republic
    Inorg Chem 51:577-90. 2012
  10. ncbi FDG-PET is superior to gallium scintigraphy in staging and more sensitive in the follow-up of patients with de novo Hodgkin lymphoma: a blinded comparison
    Jonathan W Friedberg
    James P Wilmot Cancer Center, University of Rochester, Rochester, New York 14642, USA
    Leuk Lymphoma 45:85-92. 2004

Detail Information

Publications313 found, 100 shown here

  1. ncbi Single gallium nitride nanowire lasers
    Justin C Johnson
    Department of Chemistry, University of California, Berkeley, California 94720 1460, USA
    Nat Mater 1:106-10. 2002
    ..b>Gallium nitride (GaN) is a wide-bandgap semiconductor of much practical interest, because it is widely used in ..
  2. ncbi Second harmonic generation in gallium phosphide photonic crystal nanocavities with ultralow continuous wave pump power
    Kelley Rivoire
    E L Ginzton Laboratory, Stanford University, Stanford, CA 94305 4085, USA
    Opt Express 17:22609-15. 2009
    We demonstrate second harmonic generation in photonic crystal nanocavities fabricated in the semiconductor gallium phosphide...
  3. ncbi Gallium poisoning: a rare case report
    Chris S Ivanoff
    College of Dentistry, The University of Tennessee Health Science Center, 875 Union Avenue, Memphis, TN 38163, USA
    Food Chem Toxicol 50:212-5. 2012
    The authors present a case of a college student who suffered acute gallium poisoning as a result of accidental exposure to gallium halide complexes. This is extremely rare and has never been reported in the literature...
  4. ncbi Effect of gallium arsenide diode laser on human periodontal disease: a microbiological and clinical study
    Selcuk Yilmaz
    Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul, Turkey
    Lasers Surg Med 30:60-6. 2002
    ....
  5. ncbi Surfactant-free, large-scale, solution-liquid-solid growth of gallium phosphide nanowires and their use for visible-light-driven hydrogen production from water reduction
    Jianwei Sun
    Joint Center for Artificial Photosynthesis JCAP, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Am Chem Soc 133:19306-9. 2011
    ..The results indicate that colloidal surfactant-free GaP NWs combined with potent surface electrocatalysts could serve as promising photocathodes for artificial photosynthesis...
  6. ncbi Combined administration of oxalic acid, succimer and its analogue for the reversal of gallium arsenide-induced oxidative stress in rats
    Swaran J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Arch Toxicol 76:269-76. 2002
    b>Gallium arsenide (GaAs), a group III-VA intermetallic semiconductor, possesses superior electronic and optical properties and has a wide application in the electronics industry...
  7. pmc The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent
    Ehud Banin
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:16761-6. 2008
    ..Here we report the novel use of a metallo-complex, desferrioxamine-gallium (DFO-Ga) that targets P. aeruginosa iron metabolism...
  8. ncbi Comparison of 18F-FDG and 68Ga PET imaging in the assessment of experimental osteomyelitis due to Staphylococcus aureus
    Tatu J Makinen
    Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, University of Turku, Turku, Finland
    Eur J Nucl Med Mol Imaging 32:1259-68. 2005
    ..This experimental study compared 18F-FDG and 68Ga in PET imaging of osteomyelitis and normal bone healing...
  9. ncbi Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium
    Jakub Simeček
    Department of Inorganic Chemistry, Univerzita Karlova Charles University, Hlavova 2030, 12843 Prague 2, Czech Republic
    Inorg Chem 51:577-90. 2012
    ..The discussed TRAP ligands are suitable alternatives for the development of (68)Ga radiopharmaceuticals...
  10. ncbi FDG-PET is superior to gallium scintigraphy in staging and more sensitive in the follow-up of patients with de novo Hodgkin lymphoma: a blinded comparison
    Jonathan W Friedberg
    James P Wilmot Cancer Center, University of Rochester, Rochester, New York 14642, USA
    Leuk Lymphoma 45:85-92. 2004
    ..The present study prospectively compares FDG-PET with gallium/SPECT scintigraphy at time of diagnosis and in follow-up of 36 patients with HD...
  11. ncbi Soft tissue reactions evoked by implanted gallium phosphide
    Cecilia E Linsmeier
    Neuronano Research Center, BMC F10, Lund University, SE 221 84 Lund, Sweden
    Biomaterials 29:4598-604. 2008
    ..Nanostructured surfaces may improve electrical properties and lower evoked tissue responses. Vertical gallium phosphide (GaP) nanowires epitaxially grown from a GaP surface is one way of creating nanostructured electrodes...
  12. ncbi Study of the structural role of gallium and aluminum in 45S5 bioactive glasses by molecular dynamics simulations
    Gianluca Malavasi
    Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via G Campi 183, 41125 Modena, Italy
    J Phys Chem B 117:4142-50. 2013
    The structural properties of phosphosilicate glasses based on the 45S5 Bioglass doped with gallium and aluminum (46.2 SiO2·24.3Na2O·26.9CaO·2.6P2O5·1...
  13. ncbi Comparison of (11)C-acetate positron emission tomography and (67)Gallium citrate scintigraphy in patients with hepatocellular carcinoma
    Shuren Li
    Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
    Liver Int 26:920-7. 2006
    ..The aim of this study was to compare prospectively the Gallium-67 citrate ((67)Ga) scintigraphy results with those obtained by positron emission tomography (PET) using (11)C-..
  14. ncbi Vapor-solid growth of one-dimensional layer-structured gallium sulfide nanostructures
    Guozhen Shen
    Wuhan National Laboratory for Optoelectronics and College of Optoelectronic Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China
    ACS Nano 3:1115-20. 2009
    b>Gallium sulfide (GaS) is a wide direct bandgap semiconductor with uniform layered structure used in photoelectric devices, electrical sensors, and nonlinear optical applications...
  15. ncbi Metalloprobes: synthesis, characterization, and potency of a novel gallium(III) complex in human epidermal carcinoma cells
    Scott E Harpstrite
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University Medical School, Box 8225, 510 S Kingshighway Blvd, St Louis, MO 63110, United States
    J Inorg Biochem 101:1347-53. 2007
    ..Herein, we synthesized and structurally characterized a gallium(III) complex (5) of the naphthol-Schiff base ligand...
  16. ncbi In vivo and in vitro modulation of carp (Cyprinus carpio L.) phagocyte oxidative burst activity by gallium
    Stéphane Betoulle
    Laboratory of Eco Toxicology and International Institute for Metal Ions Research, Reims Champagne Ardenne University, Reims, France
    J Toxicol Environ Health A 65:603-15. 2002
    Since gallium is a metal ion used in semiconductor industry, the toxicological effects were previously evaluated in mammals but the ecotoxicological impacts remain unknown...
  17. ncbi Deep-ultraviolet solar-blind photoconductivity of individual gallium oxide nanobelts
    Liang Li
    International Center for Materials Nanoarchitectonics MANA, National Institute for Materials Science NIMS, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    Nanoscale 3:1120-6. 2011
    ..Present Ga2O3 nanobelts can be exploited for future applications in photo sensing, light-emitting diodes, and optical switches...
  18. ncbi A printable form of single-crystalline gallium nitride for flexible optoelectronic systems
    Keon Jae Lee
    Department of Materials Science and Engineering, University of Illinois at Urbana Champaign, 104 S Goodwin Avenue, Urbana, IL 61801, USA
    Small 1:1164-8. 2005
  19. ncbi GaN@ZIF-8: selective formation of gallium nitride quantum dots inside a zinc methylimidazolate framework
    Daniel Esken
    Department of Inorganic Chemistry II, Ruhr University Bochum, 44801 Bochum, Germany
    J Am Chem Soc 133:16370-3. 2011
    ..The data give evidence for the presence of GaN nanoparticles (1-3 nm) embedded in the cavities of ZIF-8, including a blue-shift of the PL emission band caused by the quantum size effect...
  20. ncbi Directing substrate morphology via self-assembly: ligand-mediated scission of gallium-indium microspheres to the nanoscale
    J Nathan Hohman
    California NanoSystems Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States
    Nano Lett 11:5104-10. 2011
    We have developed a facile method for the construction of liquid-phase eutectic gallium-indium (EGaIn) alloy nanoparticles. Particle formation is directed by molecular self-assembly and assisted by sonication...
  21. ncbi Nanosuspensions of alendronate with gallium or gadolinium attenuate neointimal hyperplasia in rats
    Hila Epstein
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
    J Control Release 117:322-32. 2007
    ..with a minimum amount of expients, could be formulated by complexing the negatively charged alendronate with gallium or gadolinium...
  22. ncbi [Evaluation of motor and sensory neuroconduction of the median nerve in patients with carpal tunnel syndrome treated with non-coherent light emitted by gallium arsenic diodes]
    C Viera Alemán
    Depart de Fisiología Aplicada, Hospital Clinico Quirurgico Hermanos Ameijeiras, La Habana, 10300, Cuba
    Rev Neurol 32:717-20. 2001
    ..A good alternative without undesired reactions is irradiation of the carpal tunnel with not coherent light between 920 and 940 nm emitted by gallium arsenide diodes, resembling the physic and therapeutic laser effects.
  23. ncbi 18F-FDG-PET, gallium-67 and somatostatin receptor scintigraphy, in ocular MALT lymphoma
    Vahid Reza Dabbagh Kakhki
    Hell J Nucl Med 11:49; author reply 50. 2008
  24. ncbi [Fever of unknown origin (FUO), scintigraphy with Gallium 67 citrate scintigraphy and malignant lymphoma of soft tissues]
    F Salinas
    Servicios de Medicina Interna y Medicina Nuclear, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia
    Rev Esp Med Nucl 23:427-8. 2004
  25. ncbi The SAM, not the electrodes, dominates charge transport in metal-monolayer//Ga2O3/gallium-indium eutectic junctions
    William F Reus
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    ACS Nano 6:4806-22. 2012
    The liquid-metal eutectic of gallium and indium (EGaIn) is a useful electrode for making soft electrical contacts to self-assembled monolayers (SAMs)...
  26. ncbi Gallium(III), cobalt(III) and copper(II) protoporphyrin IX exhibit antimicrobial activity against Porphyromonas gingivalis by reducing planktonic and biofilm growth and invasion of host epithelial cells
    Teresa Olczak
    Laboratory of Biochemistry, University of Wroclaw, Tamka 2, 50 137 Wroclaw, Poland
    Arch Microbiol 194:719-24. 2012
    ..In contrast, cobalt(III), gallium(III) and copper(II) protoporphyrin IX exhibited antimicrobial activity against P...
  27. ncbi Optically rewritable patterns of nuclear magnetization in gallium arsenide
    Jonathan P King
    Department of Chemical Engineering, University of California, 201 Gilman Hall, Berkeley, California 94720, USA
    Nat Commun 3:918. 2012
    ....
  28. ncbi Mechanism of gallium 67 accumulation in inflammatory tissue
    A Ando
    School of Allied Medical Professions, Kanazawa University, Japan
    Eur J Nucl Med 17:21-7. 1990
    The present study was undertaken to elucidate the accumulation mechanism of gallium 67 in inflammatory tissue. 67Ga accumulation in inflammatory tissue was observed by macro- and microautoradiogram...
  29. ncbi Novel semiconductor materials for the development of chemical sensors and biosensors: a review
    Nikos Chaniotakis
    Laboratory of Analytical Chemistry, Department of Chemistry, University of Crete, Voutes 71003 Iraklion, Crete, Greece
    Anal Chim Acta 615:1-9. 2008
    ..is given to the selective interaction of novel semiconductor surfaces, including doped conductive diamond, gallium nitride, and indium nitride, with the analyte, and how this interaction can be properly transduced using ..
  30. ncbi Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses
    Shruti Shruti
    Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Acta Biomater 9:4836-44. 2013
    ..Cerium, gallium and zinc trace elements were selected because of their inherent beneficial biological properties...
  31. ncbi A 3-year clinical evaluation of a gallium restorative alloy
    A Kiremitci
    Department of Restorative Dentistry, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Oral Rehabil 30:664-7. 2003
    ..One such material is gallium-based alloy restoratives...
  32. ncbi The Porphyromonas gingivalis HmuY haemophore binds gallium(iii), zinc(ii), cobalt(iii), manganese(iii), nickel(ii), and copper(ii) protoporphyrin IX but in a manner different to iron(iii) protoporphyrin IX
    Halina Wojtowicz
    University of Wrocław, Faculty of Biotechnology, Laboratory of Biochemistry, Tamka St 2, 50 137 Wrocław, Poland
    Metallomics 5:343-51. 2013
    ..HmuY binds gallium(iii), zinc(ii), cobalt(iii), manganese(iii), nickel(ii), and copper(ii) protoporphyrin IX but in a manner ..
  33. ncbi The effect of gallium-aluminum-arsenide 808-nm low-level laser therapy on healing of skin incisions made using a diode laser
    Metin Gungormus
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ataturk University, Erzurum, Turkey
    Photomed Laser Surg 27:895-9. 2009
    ..To investigate the effect of low-level laser therapy (LLLT) on healing of skin incisions made using a diode laser in rats...
  34. ncbi X-ray absorption spectroscopy of an investigational anticancer gallium(III) drug: interaction with serum proteins, elemental distribution pattern, and coordination of the compound in tissue
    Alfred A Hummer
    Institut für Biophysikalische Chemie, Universitat Wien, Althanstraße 14, 1090 Wien, Austria
    J Med Chem 55:5601-13. 2012
    Tris(8-quinolinolato)gallium(III) (1, KP46) is a very promising investigational anticancer drug...
  35. ncbi Sonodynamically induced apoptosis and active oxygen generation by gallium-porphyrin complex, ATX-70
    Nagahiko Yumita
    Yokohama College of Pharmacy, 601, Matano cho, Totsuka ku, Yokohama, Kanagawa 245 0066, Japan
    Cancer Chemother Pharmacol 66:1071-8. 2010
    ..study, we investigated the induction of apoptosis by ultrasound in the presence of the photochemically active gallium-porphyrin complex, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17-tetramethyl-porphyrin 2,18-dipropionyl diaspartic ..
  36. pmc Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response
    S D House
    Department of Biology, Seton Hall University, South Orange, NJ 07079, USA
    Cell Stress Chaperones 6:164-71. 2001
    ..In this study, male Wistar rats were stress conditioned with either stannous chloride or gallium nitrate, which have immunosuppressive effects in vivo and in vitro, or heat shock, the most intensively studied ..
  37. ncbi Setup of a scanning near field infrared microscope (SNIM): imaging of sub-surface nano-structures in gallium-doped silicon
    Jean Sebastien Samson
    Physical Chemistry II, Ruhr University Bochum, Germany
    Phys Chem Chem Phys 8:753-8. 2006
    ..Using this "chemical nanoscope" we could image a sub-surface structure of implanted gallium ions in a topographically flat silicon wafer giving evidence for a near-field contrast...
  38. pmc Clinical value of gallium-67 scintigraphy in assessment of disease activity in Wegener's granulomatosis
    R H J A Slart
    Department of Nuclear Medicine, Groningen University Medical Centre, The Netherlands
    Ann Rheum Dis 62:659-62. 2003
    Diagnosis of active pulmonary and paranasal involvement in patients with Wegener's granulomatosis (WG) can be difficult. The diagnostic value of gallium-67 scintigraphy in WG is unclear.
  39. ncbi Photochemical functionalization of gallium nitride thin films with molecular and biomolecular layers
    Heesuk Kim
    Department of Chemistry, University of Wisconsin Madison, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Langmuir 22:8121-6. 2006
    We demonstrate that photochemical functionalization can be used to functionalize and photopattern the surface of gallium nitride crystalline thin films with well-defined molecular and biomolecular layers...
  40. ncbi Arsenic moiety in gallium arsenide is responsible for neuronal apoptosis and behavioral alterations in rats
    Swaran J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 001, India
    Toxicol Appl Pharmacol 240:236-44. 2009
    b>Gallium arsenide (GaAs), an intermetallic semiconductor finds widespread applications in high frequency microwave and millimeter wave, and ultra fast supercomputers...
  41. ncbi Water-soluble cationic gallium(III) and indium(III) phthalocyanines for photodynamic therapy
    Mahmut Durmus
    Gebze Institute of Technology, Department of Chemistry, PO Box 141, Gebze 41400, Kocaeli, Turkey
    J Inorg Biochem 104:297-309. 2010
    The new tetra-non-peripheral and peripheral 2-mercaptopyridine substituted gallium(III) and indium(III) phthalocyanine complexes (np-GaPc, p-GaPc, np-InPc and p-InPc) and their quaternized derivatives (Qnp-GaPc, Qp-GaPc, Qnp-InPc and Qp-..
  42. ncbi Gallium and other main group metal compounds as antitumor agents
    Michael A Jakupec
    Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, A 1090 Vienna, Austria
    Met Ions Biol Syst 42:425-62. 2004
    b>Gallium has been the second metal to show activity against malignant tumors in humans soon after the establishment of platinum drugs in routine clinical practice...
  43. ncbi Gallium uptake by transferrin and interaction with receptor 1
    Zohra Chikh
    ITODYS Interfaces, Traitements, Organisation et Dynamique des Systemes, Université Paris 7 CNRS UMR 7086, 1 rue Guy de la Brosse, 75005, Paris, France
    J Biol Inorg Chem 12:90-100. 2007
    The kinetics and thermodynamics of Ga(III) exchange between gallium mononitrilotriacetate and human serum transferrin as well as those of the interaction between gallium-loaded transferrin and the transferrin receptor 1 were investigated ..
  44. ncbi Measurement of glomerular filtration rate with chromium-51 ethylene diamino tetraacetic acid in the presence of gallium-67 citrate: a novel method for the solution of the problem
    Georgios Arsos
    Department of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, Hippokration Hospital, Greece
    Nucl Med Commun 32:221-6. 2011
    ..This type of correction is problematic in the case of gallium-67 (⁶⁷Ga) mainly because of the close vicinity of its 300 keV photopeak with that of the 320 keV photopeak of ..
  45. ncbi Morphology control of layer-structured gallium selenide nanowires
    Hailin Peng
    Department of Materials Science and Engineering, Stanford University, Stanford, California 94305, USA
    Nano Lett 7:199-203. 2007
    ..The participation of Ga in the VLS catalyst is important for achieving different morphologies of GaSe. In addition, GaSe nanotubes are also prepared by a slow growth process...
  46. pmc In vitro and in vivo antimicrobial activities of gallium nitrate against multidrug-resistant Acinetobacter baumannii
    Luísa C S Antunes
    Department of Biology, University Roma Tre, Rome, Italy
    Antimicrob Agents Chemother 56:5961-70. 2012
    ..baumannii chemotherapy using gallium as an iron mimetic...
  47. ncbi Gallium nitride nanowire based nanogenerators and light-emitting diodes
    Chih Yen Chen
    School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
    ACS Nano 6:5687-92. 2012
    ..Moreover, the GaN nanowire LED can be lighted up by the power provided by a ZnO nanowire based nanogenerator, demonstrating a self-powered LED using wurtzite-structured nanomaterials...
  48. ncbi Co-encapsulation of gallium with gentamicin in liposomes enhances antimicrobial activity of gentamicin against Pseudomonas aeruginosa
    M Halwani
    The Novel Drug and Vaccine Delivery Systems Facility, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada P3E 2C6
    J Antimicrob Chemother 62:1291-7. 2008
    The aim of this study was to enhance the antimicrobial efficacy of a liposomal gentamicin formulation with gallium metal (Lipo-Ga-GEN) against clinical isolates of Pseudomonas aeruginosa.
  49. ncbi Dental post-operative sensitivity associated with a gallium-based restorative material
    S M Dunne
    Department of Conservative Dentistry, GKT Dental Institute, King s College London
    Br Dent J 189:310-3. 2000
    This study forms part of a 2-year longitudinal clinical trial to compare the performance of a gallium-based restorative material (Galloy) with a high copper, mercury based (Dispersalloy) control material.
  50. ncbi Synthesis, pH-dependent structural characterization, and solution behavior of aqueous aluminum and gallium citrate complexes
    M Matzapetakis
    Department of Chemistry, University of Crete, Heraklion 71409, Greece
    Inorg Chem 40:1734-44. 2001
    ..The properties of 1-6 may provide clues relevant to their biological association with humans...
  51. pmc Nanoscale footprints of self-running gallium droplets on GaAs surface
    Jiang Wu
    Arkansas Institute for Nanoscale Material Science and Engineering, University of Arkansas, Fayetteville, Arkansas, United States of America
    PLoS ONE 6:e20765. 2011
    In this work, the nanoscale footprints of self-driven liquid gallium droplet movement on a GaAs (001) surface will be presented and analyzed...
  52. pmc Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study
    Eva A Enyedy
    Department of Inorganic and Analytical Chemistry, University of Szeged, P O Box 440, H 6701, Szeged, Hungary
    Dalton Trans 40:5895-905. 2011
    ..In addition the fluorescence properties of the ligands in aqueous solution and their changes caused by Ga(III) were studied...
  53. ncbi Controlled delivery of antimicrobial gallium ions from phosphate-based glasses
    S P Valappil
    Division of Biomaterials and Tissue Engineering, University College London, Eastman Dental Institute, 256 Gray s Inn Road, London, UK
    Acta Biomater 5:1198-210. 2009
    b>Gallium-doped phosphate-based glasses (PBGs) have been recently shown to have antibacterial activity...
  54. ncbi Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase
    Christian R Kowol
    Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Med Chem 50:1254-65. 2007
    A series of gallium(III) and iron(III) complexes with five different 4N-substituted alpha-N-heterocyclic thiosemicarbazones, viz...
  55. ncbi A hypothesis for anti-nanobacteria effects of gallium with observations from treating kidney disease
    George A Eby
    George Eby Research, 14909 C Fitzhugh Road, Austin, TX 78736, United States
    Med Hypotheses 71:584-90. 2008
    ..b>Gallium has antibiotic properties to iron-dependent bacteria and has potent anti-inflammatory, anticancer and anti-..
  56. pmc Gallium modulates osteoclastic bone resorption in vitro without affecting osteoblasts
    Elise Verron
    INSERM U, LIOAD, France
    Br J Pharmacol 159:1681-92. 2010
    b>Gallium (Ga) has been shown to be effective in the treatment of disorders associated with accelerated bone loss, including cancer-related hypercalcemia and Paget's disease...
  57. ncbi The overexpression of NADPH-producing enzymes counters the oxidative stress evoked by gallium, an iron mimetic
    R Beriault
    Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON, P3E 2C6, Canada
    Biometals 20:165-76. 2007
    b>Gallium (Ga), an iron (Fe) mimetic promoted an oxidative environment and elicited an antioxidative response in Pseudomonas fluorescens. Ga-stressed P...
  58. ncbi Gallium(III) complexes of DOTA and DOTA-monoamide: kinetic and thermodynamic studies
    Vojtěch Kubíček
    Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 128 40 Prague, Czech Republic
    Inorg Chem 49:10960-9. 2010
    Given the practical advantages of the (68)Ga isotope in positron emission tomography applications, gallium complexes are gaining increasing importance in biomedical imaging...
  59. pmc The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity
    Yukihiro Kaneko
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195 7242, USA
    J Clin Invest 117:877-88. 2007
    ..Here we investigate a "Trojan horse" strategy that uses the transition metal gallium to disrupt bacterial Fe metabolism and exploit the Fe stress of in vivo environments...
  60. ncbi Port-A catheter-associated Nocardia bacteremia detected by gallium inflammation scan: a case report and literature review
    Chung Hsu Lai
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Scand J Infect Dis 36:775-7. 2004
    ..Nocardia bacteremia was diagnosed on the basis of the clinical response to removal of the catheter and the finding of increased gallium uptake, along with the Port-A catheter presented in the gallium inflammation scan.
  61. pmc Involvement of fumarase C and NADH oxidase in metabolic adaptation of Pseudomonas fluorescens cells evoked by aluminum and gallium toxicity
    Daniel Chenier
    Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada P3E 2C6
    Appl Environ Microbiol 74:3977-84. 2008
    ..In this study, aluminum (Al) and gallium (Ga), two Fe mimetics, severely impeded the ability of the soil microbe Pseudomonas fluorescens to perform ..
  62. ncbi Synthesis, structure, and molecular dynamics of gallium complexes of schizokinen and the amphiphilic siderophore acinetoferrin
    Evgeny A Fadeev
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    J Am Chem Soc 126:12065-75. 2004
    ..The molecular structure of gallium schizokinen, GaSz, was determined by combined (1)H NMR, Hartree-Fock ab initio calculations, DFT, and empirical ..
  63. ncbi Effects of different protocol doses of low power gallium-aluminum-arsenate (Ga-Al-As) laser radiation (650 nm) on carrageenan induced rat paw ooedema
    R Albertini
    Research Group of Fluorescence, IP and D UNIVAP R, Shishima Hifumi, 2911, 12244 000 Sao Jose dos Campos, SP, Brazil
    J Photochem Photobiol B 74:101-7. 2004
    ..Our results suggest that low power laser irradiation possibly exerts its anti-inflammatory effects by stimulating the release of adrenal corticosteroid hormones...
  64. ncbi Antimicrobial activity of gallium against virulent Rhodococcus equiin vitro and in vivo
    J R Harrington
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    J Vet Pharmacol Ther 29:121-7. 2006
    ..This study evaluated the antimicrobial activity of gallium against R. equi, as a potential chemoprophylactic and therapeutic agent...
  65. ncbi Phenylthiyl radical complexes of gallium(III), iron(III), and cobalt(III) and comparison with their phenoxyl analogues
    S Kimura
    , , Germany
    J Am Chem Soc 123:6025-39. 2001
    ..complexes [M(III)L(1)] (M = Ga, Fe, Co), [M(III)L(2)] (M = Ga, Fe, Co), and [M(III)L(3)] (M = Ga, Co) where the gallium and cobalt complexes possess an S = 0 and the iron complexes an S = (5)/(2) ground state. Complexes [CoL(1)]...
  66. ncbi Gallium nitrate in the treatment of lymphoma
    David J Straus
    Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Oncol 30:25-33. 2003
    b>Gallium nitrate is effective and well tolerated for the treatment of cancer-related hypercalcemia. At somewhat higher doses, gallium nitrate also has cytotoxic activity against a variety of cancers...
  67. ncbi The serum protein binding of pharmacologically active gallium(III) compounds assessed by hyphenated CE-MS techniques
    Michael Groessl
    University of Vienna, Institute of Inorganic Chemistry, Vienna, Austria
    Electrophoresis 30:2720-7. 2009
    ..Herein, the utilization of CE-MS methods for studying the binding behavior of a therapeutic gallium nitrate formulation and the anticancer drug candidate Tris(8-oxyquinolinato)gallium(III) to Tf and HSA under ..
  68. ncbi Gallium uptake in pericardial fat necrosis
    Hidemasa Takao
    Department of Radiology, Showa General Hospital, Kodaira, Tokyo, Japan
    Clin Nucl Med 29:378-9. 2004
  69. ncbi Effects of gallium on common carp (Cyprinus carpio): acute test, serum biochemistry, and erythrocyte morphology
    Jen Lee Yang
    Institute of Zoology, National Taiwan University, Taipei 106, Taiwan, ROC
    Chemosphere 53:877-82. 2003
    b>Gallium (Ga) is one of the intermetallic elements that are increasingly being used in making high-speed semiconductors such as gallium arsenide...
  70. ncbi Tamoxifen flare hypercalcemia: an additional support for gallium nitrate usage
    Govinda Pillai Arumugam
    Department of Medical Biochemistry, Dr A L M Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India
    J Bone Miner Metab 24:243-7. 2006
    ..We evaluated the effect of such a drug, gallium nitrate, on flare hypercalcemia...
  71. ncbi Crystallographic alignment of high-density gallium nitride nanowire arrays
    Tevye Kuykendall
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Mater 3:524-8. 2004
    ..and appropriate substrate selection to control the crystallographic growth directions of high-density arrays of gallium nitride nanowires with distinct geometric and physical properties...
  72. ncbi The three-dimensional structure of the gallium complex of azoverdin, a siderophore of Azomonas macrocytogenes ATCC 12334, determined by NMR using residual dipolar coupling constants
    Emeric Wasielewski
    Laboratoire de Biologie et de Génomique Structurales, Groupe de RMN, UMR 7104 CNRS, ESBS, Bd Sébastien Brant, 67400 Illkirch, France
    Biochemistry 41:12488-97. 2002
    ..the N(delta)-acetyl-N(delta)-hydroxyornithine side chains adopting extended conformations in order to chelate the gallium ion. This conformation leaves a large open space permitting access to the gallium ion...
  73. pmc Gallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection model
    Oyebode Olakanmi
    Medical Service, VA Medical Center Cincinnati, Cincinnati, Ohio 45220, USA
    Antimicrob Agents Chemother 54:244-53. 2010
    ..Fe acquisition is a potential target for novel therapies. Gallium (Ga) is a transition metal that interferes with cellular Fe metabolism by competing with Fe for uptake/..
  74. ncbi FDG PET and gallium scintigraphy for diagnosis of an advanced jejunal adenocarcinoma with distant metastases
    Gengo Yamaura
    Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University Hospital, Sendai, Japan
    Clin Nucl Med 29:825-7. 2004
  75. ncbi Toxicity of indium arsenide, gallium arsenide, and aluminium gallium arsenide
    Akiyo Tanaka
    Department of Hygiene, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Toxicol Appl Pharmacol 198:405-11. 2004
    b>Gallium arsenide (GaAs), indium arsenide (InAs), and aluminium gallium arsenide (AlGaAs) are semiconductor applications...
  76. ncbi Pre-Irradiation of blood by gallium aluminum arsenide (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi Yufu City Oita 879 5593, Japan
    Anesth Analg 107:1058-63. 2008
    ..We investigated whether pre-irradiation of blood by LLLT enhances peripheral endogenous opioid analgesia...
  77. pmc Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells
    Meiying Yang
    Division of Neoplastic Diseases, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Free Radic Biol Med 45:763-72. 2008
    The mechanisms of action of gallium nitrate, an antineoplastic drug, are only partly understood...
  78. ncbi Biological monitoring of exposures to aluminium, gallium, indium, arsenic, and antimony in optoelectronic industry workers
    Y H Liao
    Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Occup Environ Med 46:931-6. 2004
    The main objective of this study was to investigate aluminum, gallium, indium, arsenic, and antimony exposures on blood and urine levels in the optoelectronic workers. One hundred seventy subjects were enrolled in this cohort study...
  79. ncbi Gallium phosphide nanowires as a substrate for cultured neurons
    Waldemar Hällström
    Division of Solid State Physics and The Nanometer Structure Consortium, Lund University, P O Box 118, 221 00 Lund, Sweden
    Nano Lett 7:2960-5. 2007
    Dissociated sensory neurons were cultured on epitaxial gallium phosphide (GaP) nanowires grown vertically from a gallium phosphide surface. Substrates covered by 2...
  80. ncbi Anticancer activity of dinuclear gallium(III) carboxylate complexes
    Milena R Kaluderović
    Department of Oral, Maxillofacial and Facial Plastic Surgery, University of Leipzig, Nürnberger Str 57, D 04103 Leipzig, Germany
    Eur J Med Chem 45:519-25. 2010
    ..The molecular structure of 5 was determined by X-ray diffraction studies. The cytotoxic activity of the gallium(III) complexes (1-5) was tested against human tumor cell lines 8505C anaplastic thyroid cancer, A253 head and ..
  81. ncbi Resistance to the antineoplastic agent gallium nitrate results in marked alterations in intracellular iron and gallium trafficking: identification of novel intermediates
    Neil P Davies
    Children s Cancer Institute Australia for Medical Research, The Iron Metabolism and Chelation Program, Randwick, Sydney, New South Wales
    J Pharmacol Exp Ther 317:153-62. 2006
    b>Gallium (Ga) shows significant antitumor activity by markedly interfering with iron (Fe) metabolism, and (67)Ga is used as a radio-imaging agent for cancer detection...
  82. ncbi Gallium in cancer treatment
    Michael A Jakupec
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    Curr Top Med Chem 4:1575-83. 2004
    The trivalent gallium cation is capable of inhibiting tumor growth, mainly because of its resemblance to ferric iron...
  83. ncbi Randomized, double-blind, phase II trial of gallium nitrate compared with pamidronate for acute control of cancer-related hypercalcemia
    Frédérique Cvitkovic
    Centre Rene Huguenin, Saint Cloud, France
    Cancer J 12:47-53. 2006
    Both gallium nitrate and pamidronate are highly effective for acute control of cancer-related hypercalcemia. However, the proportion of patients who actually achieve normocalcemia has varied in published reports...
  84. ncbi Exposure and health risk of gallium, indium, and arsenic from semiconductor manufacturing industry workers
    H W Chen
    Department of Environmental Engineering and Health, Yuanpei University of Science and Technology, 306 Yuanpei Street, Hsinchu 300, Taiwan, Republic of China
    Bull Environ Contam Toxicol 78:123-7. 2007
  85. ncbi Size and density control of In droplets at near room temperatures
    J H Lee
    Department of Electrical Engineering, Kwangwoon University, Nowon Gu, Seoul, Korea
    Nanotechnology 20:285602. 2009
    ..This study provides an aid to understanding the formation of In droplets at near room temperatures and can find applications in the formation of quantum structures and/or nanostructures based on droplet epitaxy...
  86. ncbi Development of gallium compounds for treatment of lymphoma: gallium maltolate, a novel hydroxypyrone gallium compound, induces apoptosis and circumvents lymphoma cell resistance to gallium nitrate
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 322:1228-36. 2007
    Clinical studies have shown gallium nitrate to have significant antitumor activity against non-Hodgkin's lymphoma and bladder cancer, thus indicating that gallium-based drugs have potential for further development as antineoplastic ..
  87. ncbi Gallium, indium, and arsenic pollution of groundwater from a semiconductor manufacturing area of Taiwan
    H W Chen
    Department of Environmental Engineering and Health, Yuanpei University of Science and Technology, 306 Yuanpei Street, Hsinchu 300, Taiwan, Republic of China
    Bull Environ Contam Toxicol 77:289-96. 2006
  88. ncbi Inhibition of the proteasome activity by gallium(III) complexes contributes to their anti prostate tumor effects
    Di Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 67:9258-65. 2007
    ..b>Gallium(III) and subsequently developed gallium(III)-containing complexes have shown promising antineoplastic effects ..
  89. pmc Gallium maltolate treatment eradicates Pseudomonas aeruginosa infection in thermally injured mice
    Katrina DeLeon
    Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Antimicrob Agents Chemother 53:1331-7. 2009
    b>Gallium (Ga) is a semimetallic element that has demonstrated therapeutic and diagnostic-imaging potential in a number of disease settings, including cancer and infectious diseases...
  90. ncbi Lipid peroxidation in workers exposed to aluminium, gallium, indium, arsenic, and antimony in the optoelectronic industry
    Yen Hsiung Liao
    Kent Institute of Medicine and Health Sciences, University of Kent, and School of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan corrected
    J Occup Environ Med 48:789-93. 2006
    The objective of this study was to investigate whether exposure to aluminum, gallium, indium, arsenic, and antimony induces lipid peroxidation in humans.
  91. ncbi Synthesis, structure, and anticancer activity of gallium(III) complexes with asymmetric tridentate ligands: growth inhibition and apoptosis induction of cisplatin-resistant neuroblastoma cells
    Rajendra Shakya
    Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA
    Inorg Chem 45:6263-8. 2006
    Five gallium(III) complexes described as [Ga(III)(LX)2]ClO4, where (LX)- is the deprotonated form of a series of asymmetric ligands containing pyridine and 4,6-substituted phenol moieties, were synthesized and characterized by ..
  92. ncbi Gallium-induced cell death in lymphoma: role of transferrin receptor cycling, involvement of Bax and the mitochondria, and effects of proteasome inhibition
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226
    Mol Cancer Ther 5:2834-43. 2006
    b>Gallium nitrate is a metallodrug with clinical efficacy in non-Hodgkin's lymphoma. Its mechanisms of antineoplastic action are not fully understood...
  93. ncbi Gallium(III) complexes of 2-pyridineformamide thiosemicarbazones: cytotoxic activity against malignant glioblastoma
    Isolda C Mendes
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Eur J Med Chem 44:1870-7. 2009
    The gallium(III) complexes [Ga(2Am4DH)(2)]NO(3) (1), [Ga(2Am4Me)(2)]NO(3) (2) and [Ga(2Am4Et)(2)]NO(3) (3) were prepared with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me) and N(4)-ethyl (H2Am4Et) ..
  94. ncbi Gallium maltolate is a promising chemotherapeutic agent for the treatment of hepatocellular carcinoma
    Mei Sze Chua
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5655, USA
    Anticancer Res 26:1739-43. 2006
    Hepatocellular carcinoma (HCC) is a particularly lethal cancer with few treatment options. Since gallium is known to accumulate specifically in HCC tumors but not in non-tumor liver, we investigated two gallium compounds, gallium nitrate ..
  95. pmc The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines
    Seied Mojtaba Valiahdi
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Melanoma Res 19:283-93. 2009
    The antineoplastic properties of gallium are well documented. Owing to their robust accumulation of gallium, melanoma cells should be amenable to gallium-based anticancer drugs...
  96. ncbi Pseudolymphoma syndrome: findings on a gallium-67 citrate scan
    Girolamo Moschilla
    Department of Nuclear Medicine, Division of Medical Imaging, Royal Perth Hospital, Perth, Australia
    Clin Nucl Med 31:16-7. 2006
  97. ncbi Activity of gallium nitrate in refractory peripheral T-cell lymphoma
    ZuoMing Huang
    Department of Hematology Oncology, Tufts New England Medical Center, Boston, MA, USA
    Clin Lymphoma 6:43-5. 2005
    ..The authors report significant clinical activity of infusional gallium nitrate in a patient with stage IV PTCL disease refractory to chemotherapy.
  98. ncbi Gallium compounds as antineoplastic agents
    Christopher R Chitambar
    Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Curr Opin Oncol 16:547-52. 2004
    The purpose of this review is to provide an outline of the basic and clinical information on gallium nitrate as an antineoplastic agent...
  99. ncbi Gene expression analysis of gallium-resistant and gallium-sensitive lymphoma cells reveals a role for metal-responsive transcription factor-1, metallothionein-2A, and zinc transporter-1 in modulating the antineoplastic activity of gallium nitrate
    Meiying Yang
    Division of Neoplastic Diseases, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Mol Cancer Ther 6:633-43. 2007
    Several clinical trials have shown gallium nitrate to be an active agent in the treatment of lymphoma. Whereas gallium is known to target cellular iron homeostasis, the basis for lymphoma cell resistance to gallium is not known...
  100. ncbi Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters
    M Omura
    Department of Hygiene, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Toxicol Lett 89:123-9. 1996
    The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As2O3 (1...
  101. ncbi Gallium in cancer treatment
    Philippe Collery
    Service de cancérologie, Polyclinique Maymard, rue Marcel Paul, Bastia, France
    Crit Rev Oncol Hematol 42:283-96. 2002
    b>Gallium (Ga) is the second metal ion, after platinum, to be used in cancer treatment. Its activities are numerous and various...

Research Grants62

  1. NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
    Vijay Sharma; Fiscal Year: 2013
    ..we have identified a lead cationic and moderately hydrophobic radiopharmaceutical 1A based on generator-produced gallium-68 that demonstrates high extraction into the myocardium of normal mice and rats, including efficient clearance ..
  2. Iron Acquisition by Mycobacterium tuberculosis Within Phagocytes
    Bradley E Britigan; Fiscal Year: 2013
    ..This application will explore one potential mechanism of doing this using gallium. Thus, increased understanding of how M...
  3. Inhalable Gallium Nitrate Anti-Infective Powder for CF
    Vu L Truong; Fiscal Year: 2010
    ..The long term goal of this project (which is outside the scope of this application) is to investigate the use of gallium nitrate as an anti-infective to treat chronic P. aeruginosa lung infections in CF patients...
  4. Short Wavelength UV Sources for Treatment of Psoriasis
    JOSEPH SMART; Fiscal Year: 2006
    ..This proposal concentrates on the development of LEDs based on aluminum gallium nitride (AlGaN) alloys that can cover a large and useful portion of the UV spectrum...
  5. Development of a kit based PET molecular imaging agent: edotreotide Ga 68 for so
    James F Kronauge; Fiscal Year: 2010
    ..centers outside the US have been performing PET imaging with edotreotide Ga-68 and recently a high-quality gallium-68 generator has become available...
  6. Studies on bacterial populations and new therapeutics for CF lung infections
    Pradeep K Singh; Fiscal Year: 2013
    ..In Project 1, we examine a novel anti-infective approach that uses the metal gallium (Ga) to disrupt bacterial iron (Fe) metabolism...
  7. A kit based PET agent: edotreotide Ga 68 for clinical imaging of somatostatin rec
    James F Kronauge; Fiscal Year: 2012
    ..academic centers outside the US have been performing PET imaging with edotreotide Ga-68 and two commercial gallium-68 generators have become available...
  8. Image-guided Diagnosis and Therapy of Neuroendocrine Tumors
    M SUE O'DORISIO; Fiscal Year: 2013
    ..Our strong preliminary data generated with GMP DOTATOC (MIP) and a gallium generator (EZ), demonstrate that [68Ga]DOTATOC can now be reliably prepared using disposable GMP compliant ..
  9. Proof of Principle Evaluation of IV Gallium Nitrate in Patients with CF
    CHRISTOPHER HOOPER GOSS; Fiscal Year: 2013
    ..We have shown that a strategy that uses the metal gallium (Ga) to disrupt bacterial Fe, metabolism holds promise as an antimicrobial approach...
  10. Phase 2 Study of Intravenous Gallium Nitrate in the Treatment of Cystic Fibrosis
    CHRISTOPHER HOOPER GOSS; Fiscal Year: 2013
    ..We have shown that a strategy that uses the metal gallium (Ga) to disrupt bacterial Fe metabolism holds promise as an antimicrobial approach...
  11. HIV ASSOCIATED NEPHROPATHY IN CHILDREN
    JOSE STRAUSS; Fiscal Year: 1993
    ..persistent abnormal proteinuria or hematuria, increased kidney size or echogenicity, or decreased GFR will have a Gallium scan and a renal biopsy...
  12. CELLULAR UPTAKE AND INTERACTION OF IRON AND GALLIUM
    Christopher Chitambar; Fiscal Year: 1992
    Iron is an essential requirement for cellular proliferation. The metal gallium appears to inhibit cell growth by interfering with iron uptake and with iron-dependent steps in DNA synthesis...
  13. Gallium, a potential new therapeutic for CF airway infections
    Pradeep K Singh; Fiscal Year: 2010
    Here we investigate a novel antimicrobial approach using the metal gallium (Ga) as a "Trojan horse" to disrupt bacterial Fe metabolism...
  14. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2001
    Metal radionuclides are widely used in diagnostic imaging. Radioisotopes of gallium, indium, technetium and copper are used in nuclear medicine studies while gadolinium chelates act as paramagnetic contrast agents in conjunction with ..
  15. VCSEL technology for ultrahigh speed OCT retinal and anterior eye imaging
    VIJAYSEKHAR JAYARAMAN; Fiscal Year: 2013
    ..These advances are made feasible by lower power requirements for ophthalmic OCT and mature Gallium Arsenide materials...
  16. Ultra-soft atomic force microscope (USAFM) technology using nano-cantilevers for
    MEHDI YAZDANPANAH; Fiscal Year: 2009
    ..Metallic silver-gallium (Ag2Ga) nano- cantilevers produced by NaugaNeedles are Ideal candidates for ultra-sensitive cantilevers since (a) ..
  17. PRE-TARGETED GALLIUM-68 POSITRON EMISSION TOMOGRAPHY
    Gary Griffiths; Fiscal Year: 1999
    ..targeting with the sensitivity of positron emission tomography, and with the practical convenience of the gallium-68 generator...
  18. IRON REGULATION OF HUMAN TRANSFERRIN SYNTHESIS
    David Haile; Fiscal Year: 1999
    ..to design more effective therapies for cancer, in which transferrin is used as a carrier of toxic agents such as gallium or covalently linked ligand such as doxorubicin to target these agents to rapidly growing tumor cells which ..
  19. GALLIUM ARSENIDE SUPPRESSION OF ANTIGEN PROCESSING
    KATHLEEN MCCOY; Fiscal Year: 2003
    DESCRIPTION: (Adapted from the Investigator's Abstract) Gallium arsenide (GaAs) is a semiconductor used in the electronics industry. GaAs exposure of animals induces profound immunosuppression...
  20. AN IONIC GA-68 GENERATOR FOR USE IN NUCLEAR MEDICINE
    Michael Davis; Fiscal Year: 1980
    The proposed research is aimed at (1) the development of a radionuclide generator system for ionic gallium-68 using column chromatography (ion exchange or adsorption chromatography), and (2) the labeling of biologically active proteins ..
  21. Shared Instrument: Focus microPET
    Steven Larson; Fiscal Year: 2005
    ..19/9 Ebco cyclotron, producing a broad array of positron-emitting radionuclides (eg carbon-11, fluorine-18, gallium-66, yttium-86, iodine-124 etc) and radiotracers (e.g...
  22. PET Radiotracers to Evaluate Tumor Multidrug Resistance
    Mark Green; Fiscal Year: 2006
    The objective of this project is the development of novel gallium radiopharmaceuticals for non-invasive assessment of tumor multidrug resistance using positron emission tomography (PET)...
  23. ISOPRENE, INDIUM PHOSPHIDE, GALLIUM ARSENIDE
    Billy Chou; Fiscal Year: 2000
    ..of this project is to determine the potential toxicity and carcinogenicity of isoprene, indium phosphide, gallium arsenide, and optionally glutaraldehyde, by inhalation to Fischer 344 rats and B6C3Fl mice...
  24. RADIOPHARMACEUTICALS LABELED WITH METAL RADIONUCLIDES
    Mark Green; Fiscal Year: 1993
    ..the development of blood flow tracers labeled with generator-produced positron-emitting nuclides (copper-62 and gallium-68)...
  25. Use of Gallium to Prevent Pseudomonas Biofilm Formation
    Bradley Britigan; Fiscal Year: 2005
    ..aeruginosa biofilm formation and enhances its susceptibility to tobramycin. Gallium (Ca), a group IliA transition metal disrupts the Fe metabolism of many cell types...
  26. Short Wavelength UV LEDs Based on Bulk Nitride Substrates
    LEO SCHOWALTER; Fiscal Year: 2005
    ..The proposed approach is based on the fabrication of UV LEDs in the aluminum gallium nitride (AIGaN) material system on a recently-developed bulk single-crystal aluminum nitride (AIM) substrate...
  27. STUDY OF GALLIUM ACCUMULATION IN INFLAMMATORY LESIONS
    Min Fu Tsan; Fiscal Year: 1980
    The purpose of this project is to study the mechanism of gallium-67 accumulation in inflammatory lesions. We have demonstrated that gallium-67 is taken up by human polymorphonuclear leukocytes (PMN) and a variety of microorganisms...
  28. ANTI-REFLUX SURGERY FOR LONG-TERM URINARY DIVERSION
    Jerome Richie; Fiscal Year: 1980
    ..b>Gallium-67 citrate scans and antibody-coated bacteria will be correlated with histologic evidence (biopsy) of ..
  29. Molecular Modeling in Metal Based Imaging Agent Design
    DAVID REICHERT; Fiscal Year: 2001
    ..new force fields for metals of interest in imaging modalities such as SPECT, PET and MRI, these include copper, gallium, indium, technetium, and gadolinium...
  30. GALLIUM THERAPY FOR MYCOBACTERIAL INFECTIONS
    Larry Schlesinger; Fiscal Year: 1999
    ..b>Gallium (Ga), a group IIIA transition metal, particularly in the form of Ga nitrate [Ga(NO3)3], has been used clinically ..
  31. Tumor uptake of Ga-67 by photodegraded nifedipine
    Kathryn Morton; Fiscal Year: 2004
    ..by Applicant): This proposal is the first competing renewal of a 3-year RO1 grant to improve the uptake of gallium-67 for tumor imaging...
  32. CULTURED EPIDERMAL GRAFTS FOR BURN PATIENTS
    Meena Katdare; Fiscal Year: 2005
    ..Preliminary studies have also shown that gallium nitrate (GN), a group III transitional element, induces dermal fibroblasts to upregulate integrin expression and ..
  33. ROLE OF MMPS IN ALLOGRAFT REJECTION AND ACCEPTANCE
    Robert Fairchild; Fiscal Year: 2001
    ..In Specific Aim 3 we will test mechanisms regulating CD4+ T cell production of MMP-9 in gallium nitrate and m anti-CD4 mAb treated recipients of allogeneic cardiac grafts...
  34. Molecular Imaging by Affinity Enhancement PET
    Gary Griffiths; Fiscal Year: 2003
    ..This secondary recognition hapten will be radiolabeled with gallium-68, a positron-emitting radionuclide, and will be molecularly designed to rapidly flush from the living system if ..
  35. EFFECT OF GALLIUM ON BONE
    Richard Bockman; Fiscal Year: 1992
    Title; Effect of Gallium on Bone The major objective of this continuation application is to study the effects of gallium, a group IIIa meal, on bone metabolism...
  36. EASTERN PEDIATRIC ONCOLOGY CONSORTIUM
    STEVEN ARKIN; Fiscal Year: 2000
    ..Specific pilot studies will include a phase I study of Gallium Nitrate, a phase I Study of 9-cis retinoic acid and novel cell cycle based therapeutic approaches to ..
  37. Cellular Targets for Gallium Compounds in Lymphoma
    Christopher Chitambar; Fiscal Year: 2008
    ..In early clinical trials, gallium nitrate (NSC15200) demonstrated significant clinical activity in lymphoma but its use in lymphoma was never ..
  38. Novel Ternary Ligand 99m Tc-Nitrido Complexes as Heart Imaging Agents
    Shuang Liu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. Novel Cationic 99mTc Complexes for Heart Imaging
    Shuang Liu; Fiscal Year: 2006
    ..Successful development of new 99mTc perfusion imaging agents will have a profound impact on diagnostic evaluation, risk stratification, and therapeutic decision-making in patients with CAD. ..
  40. Utility of [F-18] fluoroDOPA for neonatal hyperinsulism: A Phase II
    Chaitanya Divgi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. Model for the Prevention of Post-Transplant Skin Cancer
    Anne Vanbuskirk; Fiscal Year: 2005
    ..This model will provide the pre-clinical basis for new clinical trials in immunosuppressed patients, who are at extremely high risk for developing life-threatening, UV-induced SCC. ..
  42. Pre-Conditioning Pancreatic Islets for Transplantation
    Ginny Bumgardner; Fiscal Year: 2006
    ..The effect of oxygen pre-conditioning on islet viability and function in vivo will be determined using fluorescence microscopy and the marginal mass model of islet transplantation. ..
  43. Lung tumor detection using biomagnetic imaging
    LAUREL SILLERUD; Fiscal Year: 2004
    ..abstract_text> ..
  44. In vivo testing of the role of TGFb in PTLD
    Anne Vanbuskirk; Fiscal Year: 2003
    ..The results from this pilot study will indicate whether TGFb is crucial to tumor formation in the SCID-Hu PBL mouse model. ..
  45. PET IMAGING OF THE 5HT TRANSPORTER IN ALCOHOLISM
    Zsolt Szabo; Fiscal Year: 2003
    ..The results of this project will lead to better understanding of the role of serotonin in the biological vulnerability for alcoholism and may lead to improved approaches to prevent and treat alcoholism. ..
  46. RESEARCH TRAINING IN IMAGING METHODS FOR CANCER
    Stephen Moore; Fiscal Year: 2002
    ..Some didactic course work is offered at Harvard Medical School, Harvard School of Public Health, and Massachusetts Institute of Technology. The patient population includes those treated at Dana-Farber-Partners Cancer Care. ..
  47. PTLD: cytokine production and gene polymorphisms
    Robert Baiocchi; Fiscal Year: 2005
    ..Our overall goal is to use this data as a springboard for R01 proposals to study the molecular epidemiology of PTLD and to perform prospective therapeutic clinical trials in PTLD patients. ..