cobalt

Summary

Summary: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.

Top Publications

  1. ncbi Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha
    Yong Yuan
    Genome Research Institute, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0505, USA
    J Biol Chem 278:15911-6. 2003
  2. ncbi CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2
    Jean Pascal Piret
    Laboratoire de Biologie et Biochimie Cellulaire, FUNDP, 5000 Namur, Belgium
    Ann N Y Acad Sci 973:443-7. 2002
  3. ncbi Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model
    Shuichi Ohtomo
    Institute of Medical Sciences and Division of Nephrology, Hypertension and Metabolism, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Nephrol Dial Transplant 23:1166-72. 2008
  4. ncbi Six-year results of a prospective study of metal ion levels in young patients with metal-on-metal hip resurfacings
    J Daniel
    The McMinn Centre, 25 Highfield Road, Birmingham B15 3DP, UK
    J Bone Joint Surg Br 91:176-9. 2009
  5. ncbi HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    M Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 292:464-8. 2001
  6. ncbi Sensitivity and specificity of blood cobalt and chromium metal ions for predicting failure of metal-on-metal hip replacement
    A J Hart
    Imperial College London, Department of Musculoskeletal Surgery, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
    J Bone Joint Surg Br 93:1308-13. 2011
  7. ncbi Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism
    K Salnikow
    Nelson Institute of Environmental Medicine and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016, USA
    Cancer Res 60:3375-8. 2000
  8. ncbi Predictive toxicology of cobalt nanoparticles and ions: comparative in vitro study of different cellular models using methods of knowledge discovery from data
    Limor Horev-Azaria
    Department of Physiology and Pharmacology, Faculty of Medicine, and the Marian Gertner Institute for Medical Nanosystems, Tel Aviv University, Tel Aviv 69978, Israel
    Toxicol Sci 122:489-501. 2011
  9. ncbi Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering
    Chengtie Wu
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People s Republic of China
    Biomaterials 33:2076-85. 2012
  10. pmc Hypoxic preconditioning with cobalt of bone marrow mesenchymal stem cells improves cell migration and enhances therapy for treatment of ischemic acute kidney injury
    Xiaofang Yu
    Department of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 8:e62703. 2013

Detail Information

Publications383 found, 100 shown here

  1. ncbi Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha
    Yong Yuan
    Genome Research Institute, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0505, USA
    J Biol Chem 278:15911-6. 2003
    ..It has previously been established that cobalt mimics hypoxia and causes accumulation of HIF-1alpha and HIF-2alpha...
  2. ncbi CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2
    Jean Pascal Piret
    Laboratoire de Biologie et Biochimie Cellulaire, FUNDP, 5000 Namur, Belgium
    Ann N Y Acad Sci 973:443-7. 2002
    ..In order to study how HIF-1 can modulate apoptosis, we studied whether hypoxia or cobalt chloride, a chemical inducer of HIF-1, could influence apoptosis induced by tert-butyl hydroperoxide (t-BHP), ..
  3. ncbi Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model
    Shuichi Ohtomo
    Institute of Medical Sciences and Division of Nephrology, Hypertension and Metabolism, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Nephrol Dial Transplant 23:1166-72. 2008
    Chronic renal hypoxia is suspected to play a pathogenic role in the genesis of diabetic nephropathy (DN). Cobalt enhances the activity of the hypoxia-inducible factor (HIF), a key factor in the defence against hypoxia...
  4. ncbi Six-year results of a prospective study of metal ion levels in young patients with metal-on-metal hip resurfacings
    J Daniel
    The McMinn Centre, 25 Highfield Road, Birmingham B15 3DP, UK
    J Bone Joint Surg Br 91:176-9. 2009
    ..previously shown an early increase in the 24-hour urinary excretion of metal ions, reaching a peak at six months (cobalt) and one year (chromium) after operation...
  5. ncbi HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    M Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 292:464-8. 2001
    ..Because proline hydroxylation requires molecular oxygen and Fe(2+), this protein modification may play a key role in mammalian oxygen sensing...
  6. ncbi Sensitivity and specificity of blood cobalt and chromium metal ions for predicting failure of metal-on-metal hip replacement
    A J Hart
    Imperial College London, Department of Musculoskeletal Surgery, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
    J Bone Joint Surg Br 93:1308-13. 2011
    ..We investigated the 7 ppb cut-off level for the maximum of cobalt or chromium and determined optimal mathematical cut-off levels from receiver-operating characteristic curves...
  7. ncbi Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism
    K Salnikow
    Nelson Institute of Environmental Medicine and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016, USA
    Cancer Res 60:3375-8. 2000
    Nickel (Ni2+) and cobalt (Co2+) mimic hypoxia and were used as a tool to study the role of oxygen sensing and signaling cascades in the regulation of hypoxia-inducible gene expression...
  8. ncbi Predictive toxicology of cobalt nanoparticles and ions: comparative in vitro study of different cellular models using methods of knowledge discovery from data
    Limor Horev-Azaria
    Department of Physiology and Pharmacology, Faculty of Medicine, and the Marian Gertner Institute for Medical Nanosystems, Tel Aviv University, Tel Aviv 69978, Israel
    Toxicol Sci 122:489-501. 2011
    The toxicological effects of cobalt nanoparticles (Co-NPs) aggregates were examined and compared with those of cobalt ions (Co-ions) using six different cell lines representing lung, liver, kidney, intestine, and the immune system...
  9. ncbi Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering
    Chengtie Wu
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People s Republic of China
    Biomaterials 33:2076-85. 2012
    ..Ionic cobalt (Co) is established as a chemical inducer of hypoxia-inducible factor (HIF)-1α, which induces hypoxia-like ..
  10. pmc Hypoxic preconditioning with cobalt of bone marrow mesenchymal stem cells improves cell migration and enhances therapy for treatment of ischemic acute kidney injury
    Xiaofang Yu
    Department of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 8:e62703. 2013
    ..b>Cobalt was used as hypoxia mimetic preconditioning (HMP)...
  11. pmc A cobalt complex redox shuttle for dye-sensitized solar cells with high open-circuit potentials
    Jun Ho Yum
    Laboratory for Photonics and Interfaces, Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Nat Commun 3:631. 2012
    ..voltage of over 1,000 mV in mesoscopic dye-sensitized solar cells incorporating a molecularly engineered cobalt complex as redox mediator...
  12. ncbi 3D graphene-cobalt oxide electrode for high-performance supercapacitor and enzymeless glucose detection
    Xiao Chen Dong
    Key Laboratory for Organic Electronics and Information Displays KLOEID, Institute of Advanced Materials IAM, Nanjing University of Posts and Telecommunications NUPT, 9 Wenyuan Road, Nanjing, 210046, China
    ACS Nano 6:3206-13. 2012
    Using a simple hydrothermal procedure, cobalt oxide (Co(3)O(4)) nanowires were in situ synthesized on three-dimensional (3D) graphene foam grown by chemical vapor deposition...
  13. ncbi Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 68:2714-25. 2005
    ..We have also shown that pretreatment of cobalt confers renoprotection in the ischemia/reperfusion (I/R) injury, in association with the up-regulation of hypoxia-..
  14. ncbi Effects of polyamines on the DNA-reactive properties of dimeric mithramycin complexed with cobalt(II): implications for anticancer therapy
    Ming Hon Hou
    Biotechnology Center, National Chung Hsing University, Taichung, 402 Taiwan
    Biochemistry 48:4691-8. 2009
    ..Our study suggests a novel method for enhancing the anticancer activity of DNA-binding metalloantibiotics through polyamine depletion...
  15. ncbi Structural analysis of DNA interactions with biogenic polyamines and cobalt(III)hexamine studied by Fourier transform infrared and capillary electrophoresis
    Amin Ahmed Ouameur
    Department of Chemistry Biology, University of Quebec at Trois Rivieres, C P 500, Trois Rivieres, Quebec G9A 5H7, Canada
    J Biol Chem 279:42041-54. 2004
    ..It has been shown that biogenic polyamines cause DNA condensation and aggregation similar to that of inorganic cobalt(III)hexamine cation, which has the ability to induce DNA conformational changes...
  16. ncbi Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line
    X H Liu
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Clin Exp Metastasis 17:687-94. 1999
    ..We examined the relationship between COX-2 expression and VEGF induction in response to cobalt chloride (CoCl2)-simulated hypoxia in three human prostate cancer cell lines with differing biological phenotypes...
  17. ncbi Engineered cobalt oxide nanoparticles readily enter cells
    Elena Papis
    Department of Biotechnology and Molecular Science, Insubria University, Varese, Italy
    Toxicol Lett 189:253-9. 2009
    ..The same characteristics that make cobalt-based NPs so attractive raise serious questions about their safety. In this context, we investigated Co3O4-NPs...
  18. ncbi Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast
    Sayomi Ryuko
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kusunoki cho 7 5 1, Chuo Ku, Kobe 650 0017, Japan
    Mol Genet Genomics 287:651-62. 2012
    b>Cobalt is an essential micronutrient but is toxic when present in excess. To study cobalt homeostasis we performed a genome-wide screen for deletion strains that show sensitivity or resistance to CoCl(2)...
  19. pmc Nickel, cobalt, chromium, palladium and gold induce a mixed Th1- and Th2-type cytokine response in vitro in subjects with contact allergy to the respective metals
    J T Minang
    Department of Immunology, Stockholm University, Stockholm, Sweden
    Clin Exp Immunol 146:417-26. 2006
    ..to other metals involved in contact allergy has been limited, we investigated the cytokine profile induced by Ni, cobalt (Co), chromium (Cr), palladium (Pd) and gold (Au) in PBMC from patients with patch test reactivity to the ..
  20. ncbi Resistive switching multistate nonvolatile memory effects in a single cobalt oxide nanowire
    Kazuki Nagashima
    Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan
    Nano Lett 10:1359-63. 2010
    ..These findings would open up opportunities to explore not only for the intrinsic nanoscale RS mechanisms with the ultimate size limit but also for next generation multistate three-dimensional ReRAM...
  21. ncbi Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein
    M A Goldberg
    Howard Hughes Medical Institute, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
    Science 242:1412-5. 1988
    ..The human hepatoma cell line Hep3B regulates its production of Epo in a physiologic manner. Either hypoxia or cobalt chloride markedly increases expression of Epo mRNA as well as production of biologically active and ..
  22. pmc Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells
    Zhi jun Dai
    Department of Oncology, The Second Affiliated Hospital, Medical School of Xi an Jiaotong University, Xi an, China
    J Exp Clin Cancer Res 31:28. 2012
    ..This study investigated the variation of hypoxia-inducible factor-1α(HIF-1α) expression and the apoptosis effect of hypoxia stimulated by cobalt chloride (CoCl(2)) in pancreatic cancer PC-2 cells.
  23. ncbi Severe cobalt poisoning with loss of sight after ceramic-metal pairing in a hip--a case report
    Wolfram Steens
    Franziskus Hospital Münster, Orthopädie, Germany
    Acta Orthop 77:830-2. 2006
  24. ncbi Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats
    Makiko Matsumoto
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 14:1825-32. 2003
    ..This study evaluated the efficacy of cobalt, which inhibits HIF-1 degradation and increases the expression level of hypoxia-related genes, in an acute ..
  25. ncbi Serum metal ion levels after second-generation metal-on-metal total hip arthroplasty
    Takao Imanishi
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Arch Orthop Trauma Surg 130:1447-50. 2010
    ..We investigated serum levels of cobalt and chromium ions in patients with successfully implanted second-generation metal-on-metal total hip arthroplasty (..
  26. pmc The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis
    Joe Morrissey
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Plant Cell 21:3326-38. 2009
    ..Ferroportins also play a role in cobalt homeostasis; a survey of Arabidopsis accessions for ionomic phenotypes showed that truncation of FPN2 results in ..
  27. ncbi A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells
    Kyoung S Kim
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 177:7211-24. 2006
    ..Pharmacological agents, which inhibit HIF-1alpha, may possibly ameliorate inflammation associated with hypoxia in pathological diseases...
  28. ncbi Hypoxia inducible factor-1 alpha, endothelial progenitor cells, monocytes, cardiovascular risk, wound healing, cobalt and hydralazine: a unifying hypothesis
    Michel R Hoenig
    Clinical Sciences, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Curr Drug Targets 9:422-35. 2008
    ..of all cardiovascular risk factors and discusses the manipulation of this system with existing drugs such as cobalt or hydralazine...
  29. pmc Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization
    Yan Zhang
    Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588 0664, USA
    BMC Genomics 10:78. 2009
    Nickel (Ni) and cobalt (Co) are trace elements required for a variety of biological processes. Ni is directly coordinated by proteins, whereas Co is mainly used as a component of vitamin B12...
  30. ncbi Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane
    John R Forbes
    Department of Biochemistry, McGill University, 3655 Sir William Osler Promenade, Montreal, QC, Canada, H3G1Y6
    Blood 102:1884-92. 2003
    ..These results clarify the mechanism by which Nramp1 contributes to phagocyte defenses against infections...
  31. ncbi Induction of protein oxidation by cobalt and chromium ions in human U937 macrophages
    Alain Petit
    Division of Orthopaedic Surgery, Lady Davis Institute for Medical Research, McGill University, The SMBD Jewish General Hospital, 3755 Ch Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Biomaterials 26:4416-22. 2005
    ..cellular effect of metal ions from metal-on-metal prostheses, the aim of this study was to examine the effect of cobalt (Co2+) and chromium (Cr3+) ions on protein oxidation in human U937 macrophages...
  32. ncbi Lymphocyte proliferation responses in patients with pseudotumors following metal-on-metal hip resurfacing arthroplasty
    Young Min Kwon
    Nuffield Department of Orthopaedic Surgery, University of Oxford, Windmill Road, Oxford OX3 7LD, United Kingdom
    J Orthop Res 28:444-50. 2010
    ..A delayed hypersensitivity reaction type IV to nickel (Ni), chromium (Cr), or cobalt (Co) has been suggested to play a role in its aetiology...
  33. ncbi Induction of hypoxia-inducible factor-1alpha overexpression by cobalt chloride enhances cellular resistance to photodynamic therapy
    Zhenyu Ji
    Department of Pathology, The National Hospital The Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    Cancer Lett 244:182-9. 2006
    ..High-expression of HIF-1alpha induced in vitro by cobalt chloride (CoCl(2))-mediated chemical hypoxia mimic was clearly seen in the Het-1A cell line...
  34. ncbi Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non-smoking, Norwegian women in the HUNT 2 study
    Helle Margrete Meltzer
    Division of Environmental Medicine, Department of Food Safety and Nutrition, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N 0403 Oslo, Norway
    Environ Res 110:497-504. 2010
    ..To obtain more knowledge about such associations, the divalent metal ions cadmium (Cd), manganese (Mn), cobalt (Co), copper (Cu), zinc (Zn) and lead (Pb) and parameters of Fe metabolism (serum ferritin, haemoglobin (Hb) and ..
  35. ncbi One-year prospective comparative study of three large-diameter metal-on-metal total hip prostheses: serum metal ion levels and clinical outcomes
    J F Lardanchet
    Department of Orthopaedic Surgery, North Amiens Teaching Hospital Center, 1, Place Victor Pauchet, 80000 Amiens, France
    Orthop Traumatol Surg Res 98:265-74. 2012
    ..are related to the geometry and metal composition of the prosthesis components, we conducted a prospective study of clinical outcomes and serum chromium and cobalt levels 1 year after implantation of three different acetabular cups.
  36. ncbi Circulating levels of cobalt and chromium from metal-on-metal hip replacement are associated with CD8+ T-cell lymphopenia
    A J Hart
    Department of Musculoskeletal Surgery Charing Cross, Imperial College, London, England
    J Bone Joint Surg Br 91:835-42. 2009
    ..Our aim was to evaluate the relationship between metal-on-metal replacements, the levels of cobalt and chromium ions in whole blood and the absolute numbers of circulating lymphocytes...
  37. ncbi The effect of component size and orientation on the concentrations of metal ions after resurfacing arthroplasty of the hip
    D J Langton
    Joint Replacement Unit, University Hospital of North Tees, Hardwick, Stockton on Tees TS19 8PE, UK
    J Bone Joint Surg Br 90:1143-51. 2008
    ..Chromium and cobalt ion concentrations in the whole blood of patients with smaller (<or= 51 mm) femoral components were ..
  38. ncbi Whole blood metal ion concentrations in correlation with activity level in three different metal-on-metal bearings
    Christophe A Pattyn
    Department of Orthopedic Surgery and Traumatology, Ghent University Hospital, Ghent, Belgium
    J Arthroplasty 26:58-64. 2011
    ..Whole blood cobalt and chromium levels were analyzed preoperatively, at 3 months, 6 months, 1 year, and 2 years...
  39. pmc Update on the genotoxicity and carcinogenicity of cobalt compounds
    D Lison
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Clos Chapelle aux Champs 3054, 1200 Bruxelles, Belgium
    Occup Environ Med 58:619-25. 2001
    To integrate recent understandings of the mechanisms of genotoxicity and carcinogenicity of the different cobalt compounds.
  40. pmc Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α
    Sankarathi Balaiya
    University of Florida College of Medicine, Department of Ophthalmology Jacksonville, FL, USA
    Mol Vis 18:114-20. 2012
    ..In this study, we investigated the role of hypoxia induced SIRT1 in choroidal neovascularization in relation to age-related macular degeneration...
  41. ncbi Serum levels of cobalt and chromium in patients with Sikomet metal-metal total hip replacements
    Ingrid Milosev
    Jozef Stefan Institute, Department of Physical and Organic Chemistry, Ljubljana, Slovenia
    J Orthop Res 23:526-35. 2005
    ..retrospective group of 25 patients sampled at average 60 +/- 20 months postoperatively showed a 3-fold increase in cobalt and a 4.4-fold increase in chromium compared with the control group...
  42. ncbi Oxygen reduction electrocatalyst based on strongly coupled cobalt oxide nanocrystals and carbon nanotubes
    Yongye Liang
    Department of Chemistry, Stanford University, Stanford, California 94305, United States
    J Am Chem Soc 134:15849-57. 2012
    ..Here, we used a simple two-step method to synthesize cobalt oxide/carbon nanotube (CNT) strongly coupled hybrid as efficient ORR catalyst by directly growing nanocrystals on ..
  43. ncbi Cellular distribution and degradation of cobalt ferrite nanoparticles in Balb/3T3 mouse fibroblasts
    Patrick Marmorato
    European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Ispra Va, Italy
    Toxicol Lett 207:128-36. 2011
    The effect of the concentration of cobalt ferrite (CoFe(2)O(4)) nanoparticles (NPs) on their intracellular location and distribution has been explored by synchrotron radiation X-ray and fluorescence microscopy (SR-XRF) monitoring the ..
  44. pmc Metal ion levels and functional results after either resurfacing hip arthroplasty or conventional metal-on-metal hip arthroplasty
    José M H Smolders
    Department of Orthopaedics, Hospital Rijnstate, Arnhem, The Netherlands
    Acta Orthop 82:559-66. 2011
    ....
  45. pmc The John Charnley Award: Metal-on-metal hip resurfacing versus large-diameter head metal-on-metal total hip arthroplasty: a randomized clinical trial
    Donald S Garbuz
    Division of Lower Limb Reconstruction and Oncology, Department of Orthopaedics, University of British Columbia, Room 3114, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, Canada
    Clin Orthop Relat Res 468:318-25. 2010
    ..There was no difference in quality of life between the two arms in the study. Serum levels of cobalt and chromium were measured in a subset of 30 patients...
  46. pmc Elevation of circulating HLA DR(+) CD8(+) T-cells and correlation with chromium and cobalt concentrations 6 years after metal-on-metal hip arthroplasty
    Nils P Hailer
    Department of Orthopedics, Institute of Surgical Sciences, Uppsala University Hospital, Sweden
    Acta Orthop 82:6-12. 2011
    ..We hypothesized that changes in lymphocyte subpopulations would be associated with elevated metal ion concentrations...
  47. ncbi Characteristics of an Albumin Cobalt Binding Test for assessment of acute coronary syndrome patients: a multicenter study
    R H Christenson
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Chem 47:464-70. 2001
    The ability of the N-terminal region of human albumin to bind cobalt is diminished by myocardial ischemia...
  48. ncbi A novel family of ubiquitous heavy metal ion transport proteins
    I T Paulsen
    Department of Biology, University of California at San Diego, La Jolla, CA 92093 0116, USA
    J Membr Biol 156:99-103. 1997
    ..sequenced protein members of the CDF family have been identified, several of which have been shown to transport cobalt, cadmium and/or zinc...
  49. ncbi pVHL-independent ubiquitination of HIF1alpha and its stabilization by cobalt ion
    Koichi Kanaya
    Institute of Molecular Medicine, The University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Biochem Biophys Res Commun 306:750-5. 2003
    ..We also demonstrated that Co(2+) binds to both PAS domains in the N-terminal region of HIF1alpha. These observations imply that the stability of HIF1alpha is regulated by an additional pathway through the cobalt binding of PAS domains.
  50. ncbi Serum cobalt and chromium elevations following hip resurfacing with the Cormet 2000 device
    D Gordon Allan
    Southern Illinois University, School of Medicine, Division of Orthopedics and Rehabilitation, Springfield, IL 62794 9679, USA
    J Surg Orthop Adv 16:12-8. 2007
    This study was designed to monitor serum cobalt (Co) and chromium (Cr) levels at multiple time points following hip resurfacing with the Cormet 2000 device...
  51. ncbi Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress
    Kalpana Shrivastava
    Defense Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, India
    Neurochem Int 52:368-75. 2008
    ..Administration of cobalt appreciably attenuated the RONS generation, oxidation of lipids and proteins and maintained GSH/GSSH ratio similar ..
  52. ncbi Coordination modes of a schiff base pentadentate derivative of 4-aminoantipyrine with cobalt(II), nickel(II) and copper(II) metal ions: synthesis, spectroscopic and antimicrobial studies
    Sulekh Chandra
    Department of Chemistry, Zakir Husain College, University of Delhi, New Delhi, India
    Molecules 14:174-90. 2009
    ..The nickel(II) complexes were found to have octahedral geometry, whereas cobalt(II) and copper(II) complexes were of tetragonal geometry...
  53. ncbi Correlation between inclination of the acetabular component and metal ion levels in metal-on-metal hip resurfacing replacement
    R de Haan
    University Hospital Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium
    J Bone Joint Surg Br 90:1291-7. 2008
    We examined the relationships between the serum levels of chromium and cobalt ions and the inclination angle of the acetabular component and the level of activity in 214 patients implanted with a metal-on-metal resurfacing hip replacement...
  54. ncbi A prospective metal ion study of large-head metal-on-metal bearing: a matched-pair analysis of hip resurfacing versus total hip replacement
    Paul E Beaule
    The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
    Orthop Clin North Am 42:251-7, ix. 2011
    ..Compared with HR patients, THR patients had higher median serum cobalt ion levels at 6 months (3.26 vs 1.12 μg/L, P = .002) 1 year (4.51 vs 1.02, P = .002), and 2 years (3.77 vs 1...
  55. ncbi Neuroprotection against cobalt chloride-induced cell apoptosis of primary cultured cortical neurons by salidroside
    Shuqiang Zhang
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu, People s Republic of China
    Mol Cell Biochem 354:161-70. 2011
    ..of rats as a cell model to examine whether salidroside was able to prevent against cell damage after exposure to cobalt chloride (CoCl(2)), a hypoxia-inducing agent...
  56. ncbi Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty
    Wolf Christoph Witzleb
    Department of Orthopaedic Surgery, Universty Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Acta Orthop 77:697-705. 2006
    All metal implants--and metal-on-metal bearings in particular--corrode and cause a release of metal ions. Because cobalt and chromium have been shown to be carcinogenic and mutagenic in human and animal models, systemic toxicity and ..
  57. ncbi Prevalence of pseudotumor in asymptomatic patients after metal-on-metal hip arthroplasty
    Daniel H Williams
    Division of Lower Limb Reconstruction and Oncology, Department of Orthopaedics, University of British Columbia, 910 West 10th Avenue, Vancouver, BC, Canada
    J Bone Joint Surg Am 93:2164-71. 2011
    ..A secondary purpose was to assess whether a correlation exists between elevated serum metal ion levels and pseudotumor formation...
  58. pmc Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage
    Rajkumar Tulsawani
    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68 198, USA
    BMC Neurosci 11:125. 2010
    ..The protein peroxiredoxin 6 (PRDX6) plays a pleiotropic role in negatively regulating death signaling in response to stressors, and thereby stabilizes cellular homeostasis...
  59. ncbi Metal oxide hollow nanostructures for lithium-ion batteries
    Zhiyu Wang
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore
    Adv Mater 24:1903-11. 2012
    ..It is thus anticipated that this article will shed some light on the development of advanced electrode materials for next-generation LIBs...
  60. ncbi Quantitative evaluation of susceptibility and shielding effects of nitinol, platinum, cobalt-alloy, and stainless steel stents
    Yi Wang
    Department of Radiology, Weill Medical College of Cornell University, New York, New York, USA
    Magn Reson Med 49:972-6. 2003
    ..Susceptibility induced signal loss was negligible (<1%) for nonstainless-steel (nitinol, platinum, and cobalt-alloy) stents and totally destructive (100%) for the stainless steel stent...
  61. ncbi Adverse reaction to metal debris following hip resurfacing: the influence of component type, orientation and volumetric wear
    D J Langton
    Northern Deanery, Goldcrest Way, Newcastle upon Tyne, NE15 8NY, UK
    J Bone Joint Surg Br 93:164-71. 2011
    ..There were 58 failures associated with ARMD. The median chromium and cobalt concentrations in the failed group were significantly higher than in the control group (p < 0.001)...
  62. pmc Identification of rcnA (yohM), a nickel and cobalt resistance gene in Escherichia coli
    Agnes Rodrigue
    Unité de Microbiologie et Génétique, Unité Mixte de Recherche 5122, Centre National de la Recherche Scientifique, Institut National des Sciences, Applquée de Lyon I, Villeurbanne, France
    J Bacteriol 187:2912-6. 2005
    ..We show that yohM encodes a membrane-bound polypeptide conferring increased nickel and cobalt resistance in E. coli. yohM was specifically induced by nickel or cobalt but not by cadmium, zinc, or copper...
  63. pmc A retrospective comparative study of mortality and causes of death among patients with metal-on-metal and metal-on-polyethylene total hip prostheses in primary osteoarthritis after a long-term follow-up
    Tuomo Visuri
    Research Institute of Military Medicine, Helsinki, Finland
    BMC Musculoskelet Disord 11:78. 2010
    ..We analyzed the causes of total and site-specific mortality among a cohort of patients with MM and with metal-on-polyethylene (MP) THA after a long follow-up time...
  64. ncbi Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha
    Olga Karovic
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochem Pharmacol 73:694-708. 2007
    b>Cobalt is suspected to cause memory deficit in humans and was reported to induce neurotoxicity in animal models. We have studied the effects of cobalt in primary cultures of mouse astrocytes. CoCl(2) (0.2-0...
  65. pmc Functional activity and role of cation-efflux family members in Ni hyperaccumulation in Thlaspi goesingense
    M W Persans
    Department of Chemistry, Northern Arizona University, Flagstaff 86011, USA
    Proc Natl Acad Sci U S A 98:9995-10000. 2001
    ..We propose that the high-level expression of TgMTP1 in T. goesingense accounts for the enhanced ability of this hyperaccumulator to accumulate metal ions within shoot vacuoles...
  66. ncbi Blood and urine metal ion levels in young and active patients after Birmingham hip resurfacing arthroplasty: four-year results of a prospective longitudinal study
    J Daniel
    The McMinn Centre, 25 Highfield Road, Edgbaston, Birmingham B15 3DP, UK
    J Bone Joint Surg Br 89:169-73. 2007
    This is a longitudinal study of the daily urinary output and the concentrations in whole blood of cobalt and chromium in patients with metal-on-metal resurfacings over a period of four years...
  67. ncbi Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Lab Invest 85:1292-307. 2005
    ..At 5-9 weeks after subtotal nephrectomy, cobalt was administered to rats to activate HIF...
  68. ncbi Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation
    W Zou
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Neurosci Res 64:646-53. 2001
    ..There are many reports showing that cobalt chloride (CoCl(2)) could mimic the hypoxic responses in some aspects including production of ROS in cultured cells...
  69. ncbi Cobalamin (coenzyme B12): synthesis and biological significance
    J R Roth
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Annu Rev Microbiol 50:137-81. 1996
    ..denitrificans) and an anaerobic pathway (in P. shermanii and S. typhimurium)-that differ in the point of cobalt insertion. Analysis of B12 transport in E...
  70. ncbi FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents
    Won Seok Seo
    Department of Chemistry and Laboratory for Advanced Materials, Stanford University, Stanford, California 94305, USA
    Nat Mater 5:971-6. 2006
    ..These results point to the potential of using these nanocrystals for integrated diagnosis and therapeutic (photothermal-ablation) applications...
  71. pmc A novel class of modular transporters for vitamins in prokaryotes
    Dmitry A Rodionov
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 191:42-51. 2009
    ..The shared use of energy-coupling modules was experimentally confirmed for folate, thiamine, and riboflavin transporters. We propose the name energy-coupling factor transporters for the new class of membrane transporters...
  72. ncbi Colloidal nanocrystal shape and size control: the case of cobalt
    V F Puntes
    Department of Chemistry, University of California at Berkeley, Berkeley, CA 94720, USA
    Science 291:2115-7. 2001
    ..anisotropic cadmium selenide semiconductor nanorods can be extended to the size-controlled preparation of magnetic cobalt nanorods as well as spherically shaped nanocrystals...
  73. ncbi Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1alpha and AP-1 and iNOS signaling
    Lei Xi
    Division of Cardiology, Box 980281, Virginia Commonwealth Univ, Richmond, VA 23298 0281, USA
    Am J Physiol Heart Circ Physiol 287:H2369-75. 2004
    ..The delayed protective effect of CoCl2 is achieved through a distinctive signaling mechanism involving HIF-1alpha, AP-1, and iNOS but independent of NF-kappaB activation...
  74. ncbi The association between metal ions from hip resurfacing and reduced T-cell counts
    A J Hart
    Royal National Orthopaedic Hospital, Stanmore, UK
    J Bone Joint Surg Br 88:449-54. 2006
    ..Peripheral blood samples were analysed for lymphocyte subtypes and whole blood cobalt and chromium ion levels in 68 patients (34 with metal-on-metal hip resurfacings and 34 with standard metal-on-..
  75. pmc Ni(II) and Co(II) sensing by Escherichia coli RcnR
    Jeffrey S Iwig
    Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics, Saint Louis, Missouri 63110, USA
    J Am Chem Soc 130:7592-606. 2008
    ....
  76. ncbi Metal-on-metal hip resurfacing arthroplasty: a review of periprosthetic biological reactions
    Guillaume Mabilleau
    Nuffield Department of Orthopaedic Surgery, Institute of Musculoskeletal Science, Botnar Research Centre, University of Oxford, Oxford, UK
    Acta Orthop 79:734-47. 2008
    ..The purpose of this review is to provide an overview of the current literature on the adverse periprosthetic biological reactions associated with metal-on-metal hip resurfacing arthroplasty...
  77. ncbi Cup inclination angle of greater than 50 degrees increases whole blood concentrations of cobalt and chromium ions after metal-on-metal hip resurfacing
    A J Hart
    Department of Musculoskeletal Surgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK
    Hip Int 18:212-9. 2008
    ..We identified a threshold level of 50 degrees cup inclination. Below this threshold, the mean whole blood cobalt and chromium were 1.6 ppb and 1...
  78. ncbi How do serum cobalt and chromium levels change after metal-on-metal hip resurfacing?
    Diane L Back
    Melbourne Orthopaedic Group, Melbourne, Australia
    Clin Orthop Relat Res 438:177-81. 2005
    We prospectively monitored changes in serum cobalt and chromium levels after a new generation metal-on-metal hip resurfacing and the affect on renal function...
  79. ncbi A nickel-cobalt-sensing ArsR-SmtB family repressor. Contributions of cytosol and effector binding sites to metal selectivity
    Jennifer S Cavet
    Biosciences, Medical School, University of Newcastle, Newcastle NE2 4HH, United Kingdom
    J Biol Chem 277:38441-8. 2002
    ..type ATPase (NmtA), repressing transcription in vivo except in medium supplemented with nickel or, to some extent, cobalt. In a cyanobacterial host, Synechococcus PCC 7942 strain R2-PIM8(smt), NmtR-mediated repression is alleviated by ..
  80. pmc Characterization of protein contributions to cobalt-carbon bond cleavage catalysis in adenosylcobalamin-dependent ethanolamine ammonia-lyase by using photolysis in the ternary complex
    Wesley D Robertson
    Department of Physics, Emory University, Atlanta, Georgia 30322, USA
    J Am Chem Soc 133:6968-77. 2011
    Protein contributions to the substrate-triggered cleavage of the cobalt-carbon (Co-C) bond and formation of the cob(II)alamin-5'-deoxyadenosyl radical pair in the adenosylcobalamin (AdoCbl)-dependent ethanolamine ammonia-lyase (EAL) from ..
  81. pmc Do ion levels in hip resurfacing differ from metal-on-metal THA at midterm?
    A Moroni
    Department II of Orthopaedics and Traumatology, Bologna University, Rizzoli Orthopaedic Institute, Via G C Pupilli 1, 40136 Bologna, Italy
    Clin Orthop Relat Res 469:180-7. 2011
    ..Metal-on-metal Birmingham hip resurfacing (MOM-BHR) is an alternative to metal-on-metal total hip arthroplasty (MOM-THA), especially for young and/or active patients. However, wear resulting in increased serum ion levels is a concern...
  82. ncbi Paraventricular nucleus modulates autonomic and neuroendocrine responses to acute restraint stress in rats
    Cristiane Busnardo
    Department of Pharmacology of the School of Medicine of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Auton Neurosci 158:51-7. 2010
    ..The present results show that a local PVN neurotransmission is involved in the neural pathway that controls autonomic and neuroendocrine responses, which are associated with the exposure to acute restraint stress...
  83. ncbi Structure and valency of a cobalt-phosphate water oxidation catalyst determined by in situ X-ray spectroscopy
    Matthew W Kanan
    Department of Chemistry, 6 335, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 132:13692-701. 2010
    ..Whereas cobaltates contain extended planes of CoO(6) octahedra, the Co-Pi clusters are of molecular dimensions...
  84. ncbi The effect of the diameter of metal-on-metal bearings on systemic exposure to cobalt and chromium
    J Daniel
    The McMinn Centre, 25 Highfield Road, Edgbaston, Birmingham B15 3DP, UK
    J Bone Joint Surg Br 88:443-8. 2006
    ..order to establish if bearing diameter influences the release of metal ions, we compared the whole blood levels of cobalt and chromium (at one year) and the urinary cobalt and chromium output (at one to three and four to six years) ..
  85. ncbi Changes in cobalt and chromium levels after metal-on-metal hip resurfacing in young, active Chinese patients
    Jing Yang
    Orthopedic Department, West China Hospital, Sichuan University, Chengdu, China
    J Arthroplasty 26:65-70, 70.e1. 2011
    ..The aim of our prospective study was to evaluate the serum and urine levels of cobalt (Co) and chromium (Cr) in young (age, ≤50 years), active Chinese patients who had undergone metal-on-metal ..
  86. ncbi Synthesis and coating of cobalt ferrite nanoparticles: a first step toward the obtainment of new magnetic nanocarriers
    Giovanni Baldi
    CERICOL, Colorobbia, Via Pietramarina 123, 50053 Sovigliana Vinci, Firenze, Italy
    Langmuir 23:4026-8. 2007
    Monodisperse and stable cobalt ferrite (CoFe2O4) nanoparticles (5...
  87. ncbi Online monitoring of cell metabolism to assess the toxicity of nanoparticles: the case of cobalt ferrite
    Valentina Mariani
    European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Nanobiosciences Unit, Ispra Va, Italy
    Nanotoxicology 6:272-87. 2012
    ..We focused our work on response changes of fibroblast cultures linked to exposure by cobalt ferrite NPs and compared the results to conventional in vitro assays...
  88. pmc Selective transport of zinc, manganese, nickel, cobalt and cadmium in the root system and transfer to the leaves in young wheat plants
    Valerie Page
    Institute of Plant Sciences, University of Bern, Altenbergrain 21, CH 3013 Bern, Switzerland
    Ann Bot 96:425-34. 2005
    The uptake, translocation and redistribution of the heavy metals zinc, manganese, nickel, cobalt and cadmium are relevant for plant nutrition as well as for the quality of harvested plant products...
  89. pmc AnhE, a metallochaperone involved in the maturation of a cobalt-dependent nitrile hydratase
    Sachi Okamoto
    Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver V6T 1Z3, Canada
    J Biol Chem 285:25126-33. 2010
    Acetonitrile hydratase (ANHase) of Rhodococcus jostii RHA1 is a cobalt-containing enzyme with no significant sequence identity with characterized nitrile hydratases...
  90. ncbi The biological occurrence and trafficking of cobalt
    Sachi Okamoto
    University of British Columbia Microbiology and Immunology, Vancouver, British Columbia, Canada
    Metallomics 3:963-70. 2011
    b>Cobalt is an essential trace element in both prokaryotes and eukaryotes. Nevertheless, it occurs less frequently in metalloproteins than other transition metals...
  91. ncbi Serum metal ion concentrations after unilateral vs bilateral large-head metal-on-metal primary total hip arthroplasty
    Christopher E Pelt
    University of Utah Department of Orthopaedics, Utah, USA
    J Arthroplasty 26:1494-500. 2011
    ..Elevated levels (chromium, 17 μg/L; cobalt, 19 μg/L) have been associated with poorly functioning MOM THA with metallosis...
  92. ncbi Formation of cationic peptide radicals by gas-phase redox reactions with trivalent chromium, manganese, iron, and cobalt complexes
    Christopher K Barlow
    School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, Victoria 3010, Australia
    J Am Chem Soc 127:6109-15. 2005
    ....
  93. ncbi Hypoxia-induced up-regulation of aquaporin-1 protein in prostate cancer cells in a p38-dependent manner
    Lu Tie
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences and Institute of System Biomedicine, Peking University, Beijing, China
    Cell Physiol Biochem 29:269-80. 2012
    ..We hypothesized that hypoxia might play an important role in AQP1 induction during tumorigenesis and at the late stages of tumor development...
  94. ncbi Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat
    Dhananjay Shukla
    Defence Institute of Physiology and Allied Sciences DIPAS, Lucknow Road, Timarpur, Delhi 110054, India
    Eur J Pharmacol 656:101-9. 2011
    ..high altitude injuries is hypoxic preconditioning which has potential clinical usefulness and can be mimicked by cobalt chloride...
  95. ncbi Metal Ion release with large-diameter metal-on-metal hip arthroplasty
    Pascal André Vendittoli
    Surgery Department of Maisonneuve Rosemont Hospital, University of Montreal, Montreal, Quebec, Canada
    J Arthroplasty 26:282-8. 2011
    ..Mean chromium, cobalt (Co), and titanium levels from LDH-THA were 1.3, 2.2, and 2.7 μg/L at 12 months...
  96. ncbi Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B12 anaerobic pathway
    Patricio J Santander
    Center for Biological NMR, Department of Chemistry, Texas A and M University, PO Box 3255, College Station, TX 77843 3255, USA
    Bioorg Med Chem 14:724-31. 2006
    ..a substrate for the enzymes of the anaerobic pathway to vitamin B12 led to the synthesis of three pairs of novel cobalt corrinoids...
  97. ncbi Cobalt toxicity: chemical and radiological combined effects on HaCaT keratinocyte cell line
    N Gault
    CEA Fontenay aux Roses, DSV IRCM SCSR LRTS, Fontenay aux Rose, France
    Toxicol In Vitro 24:92-8. 2010
    b>Cobalt (Co) is an essential trace element well known as a constituent of vitamin B(12), but different compounds of Co are also described as highly toxic and/or radiotoxic for individuals or the environment...
  98. ncbi High human exposure to cobalt and other metals in Katanga, a mining area of the Democratic Republic of Congo
    Célestin Lubaba Nkulu Banza
    Unité de Toxicologie et Environnement, Ecole de Santé Publique, Université de Lubumbashi, Democratic Republic of Congo
    Environ Res 109:745-52. 2009
    ..This study assessed the exposure to metals in the population of Katanga, in the south east of the Democratic Republic of Congo, using biomonitoring...
  99. ncbi Magnetic nanovectors for drug delivery
    Jim Klostergaard
    University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nanomedicine 8:S37-50. 2012
    ..are composed of one or more of the three elements that are ferromagnetic at physiological temperature: nickel, cobalt and iron...
  100. ncbi Metal ion levels following resurfacing arthroplasty of the hip: serial results over a ten-year period
    R M deSouza
    University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, UK
    J Bone Joint Surg Br 92:1642-7. 2010
    ..In these patients there is an increase in both cobalt and chromium levels above the accepted reference ranges during the first 18 months after operation...
  101. ncbi Unique biogenesis of high-molecular mass multimeric metalloenzyme nitrile hydratase: intermediates and a proposed mechanism for self-subunit swapping maturation
    Zhemin Zhou
    Institute of Applied Biochemistry and Graduate School of Life and Environmental Sciences, The University of Tsukuba, Ibaraki, Japan
    Biochemistry 49:9638-48. 2010
    ..The incorporation of cobalt into L-NHase has been found to depend on the α-subunit exchange between cobalt-free L-NHase (apo-L-NHase) and its ..

Research Grants63

  1. Orthopaedic Wear Debris, Vitamin D, and Innate Immunity
    John S Adams; Fiscal Year: 2010
    Clinical failure of total hip replacements involving polyethylene cups and cobalt-chrome femoral components will affect more than a million individuals in the coming 20-year period...
  2. Crystalline hydroxocobalamin and methemoglobin as a treatment of H2S intoxication
    PHILIPPE A HAOUZI; Fiscal Year: 2013
    ..of low dose of methemoglobin (as a source of ferric Iron) and high dose of Vitamin B12 (as a source of oxidized Cobalt)...
  3. DNA - DNA interactions with atomic detail
    Lois Pollack; Fiscal Year: 2013
    ..multivalent ions with distinctly different physical properties, ranging from the spherical trivalen inorganic ion, cobalt hexa-amine, through the more rod-like, less charge-dense polyamines found in living cell;e.g...
  4. Environmental exposure to metal mixtures and kidney disease
    Mary Fox; Fiscal Year: 2009
    ..The metals are barium, cadmium, cobalt, lead, mercury, molybdenum, and uranium...
  5. Fabrication and validation of implantable MRI markers for prostate cancer treatme
    Andrew Bright; Fiscal Year: 2010
    ..We recently invented MRI marker comprised of a cobalt chloride complex (C4) that allows accurate visualization on MRI of the implanted titanium seeds used in PB...
  6. Spinal TNF elicits AMPAr trafficking and hyperalgesia
    Linda S Sorkin; Fiscal Year: 2013
    ..I will use a combination of Western blots, subcellular fractionation, kainite induced cobalt loading and confocal microscopy...
  7. Selection, Characterization &Application of Paramagnetic Metal-specific DNAzymes
    Yi Lu; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Paramagnetic metal ions such as cobalt, copper and iron are beneficial to human health when low in concentration, but are toxic when high in ..
  8. 2011 Cell Biology of Metals Gordon Research Conference
    David P Giedroc; Fiscal Year: 2011
    ..will present recent advances in our understanding of transition metal (iron, copper, zinc, manganese and cobalt) homeostasis in cells, between cells and within organisms...
  9. Anti-fibrotic Coatings for Rapidly Exchangeable Bioprosthetic Heart Valve
    Ivan Vesely; Fiscal Year: 2010
    ..We will fabricate 8 valves each from bare cobalt-chrome, cobalt-chrome treated with a stearate coating, and from pyrolitic carbon...
  10. Biotribological Layers in Metal-on-Metal Hip Replacement
    Joshua J Jacobs; Fiscal Year: 2010
    ..and in-vitro samples and demonstrate the effect of embedded organic constituents;and 3) to demonstrate that the presence of a mechanically mixed zone will beneficially effect the (tribo-)corrosion behavior of the cobalt-chromium alloy
  11. Feasibility of Supercritical Carbon Dioxide Sterilization for Absorbable Suture M
    JANET L HUIE; Fiscal Year: 2013
    ..Gamma-irradiation requires cobalt-60 and these facilities are generally housed in large industrial or research institutions that have high operating ..
  12. ENZYMOLOGY OF THE REDUCTIVE ACETYL-COA PATHWAY
    STEPHEN WILEY RAGSDALE; Fiscal Year: 2013
    ..structures of macromolecular channels, previously unknown metal clusters, unusual roles of low-valent nickel and cobalt ions as nucleophiles, novel biochemical roles of Coenzyme A, organometallic complexes as intermediates in ..
  13. Bioengineering Research Partnership in Total Joint Replacements
    Yogesh K Vohra; Fiscal Year: 2012
    ..Specific Aim 4: Evaluate cellular response to diamond wear debris particles, as compared to polyethylene and cobalt chrome debris particles...
  14. COBALT: Comorbid Affective Disorders, AIDS/HIV, and Long Term Health
    Graham Thornicroft; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Long term objective. The objective of the COBALT (Comorbid Affective Disorders, AIDS/HIV, and Long Term Health) study is to address an important gap in research evidence for cost-effective, scalable ..
  15. WC-Co nanoparticles in initiating angiogenesis by reactive oxygen species
    Bing Hua Jiang; Fiscal Year: 2010
    ..Our preliminary results show that exposure of epithelial cells to tungsten carbide cobalt (WC-Co) nanoparticles produced high levels of reactive oxygen species (ROS)...
  16. ELECTROSTATIC SURFACE OPTIMIZATION FOR OSSEOINTEGRATION
    Michele Marcolongo; Fiscal Year: 2000
    ..In contrast, the more commonly used bone implant materials, titanium alloy (Ti6A14V) and cobalt chromium alloy, will not support osteoblast adhesion and direct bone bonding in vivo, instead the resulting ..
  17. Anti-Cancer RNA Nanoconjugates
    Adam Wanekaya; Fiscal Year: 2013
    ..novel next generation nanoparticles of manganese or magnesium oxide or doped or composites of these with cobalt and zinc...
  18. Self-contained X-ray Blood Irradiator
    BABU CHALAMALA; Fiscal Year: 2010
    ..Most blood irradiators in existence today are based on radioactive isotopes, mainly Cesium-137 and in some cases Cobalt- 60. These two isotopes constitute the most dangerous and most prevalent of all radioisotopes in the NRC inventory...
  19. New Catalytic Systems for Stereoselective C-H Amination
    X Peter Zhang; Fiscal Year: 2013
    ..For this particular proposal, we will focus on the utilization of cobalt(II) chiral porphyrin complexes [Co(II)(Por*)] as a class of new chiral catalyts to advance the enantioselective C-..
  20. REGULATION OF HEPATIC HEME METABOLISM
    HERBERT BONKOVSKY; Fiscal Year: 2009
    ..mechanism(s) that are responsible for the up-regulation of the HO-1 gene by heme (iron protoporphyrin) and cobalt protoporphyrin (CoPP). A.2...
  21. High-throughput screening and identification of scFv antibodies against glycosyla
    Margaret Macris Kiss; Fiscal Year: 2010
    ..The infected bacterium is then compartmentalized along with a cobalt-chelate "capture-bead" in a water-in-oil (W/O) emulsion...
  22. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2010
    ..These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
  23. Coboglobins-Cobalt-Substituted Hemoglobins and Myoglobin
    Brian M Hoffman; Fiscal Year: 2013
    ..abstract_text> ..
  24. ADVANCED EPR STUDIES OF B12 DEPENDENT ENZYMES
    GARY GERFEN; Fiscal Year: 2005
    ..Model cobalt(ll) compounds, including cob(ll)alamin and Co(ll)-bis(dimethylglyoximes) will also be studied to provide insight ..
  25. STUDIES TO EVALUATE THE TOXIC AND CARCINOGENIC POTENTIAL
    Jeffrey Dill; Fiscal Year: 2009
    ..This contract involves the prechronic and chronic studies of 4 chemicals by the inhalation route: 1-bromopropane, cobalt metal, diethylamine and triethylamine...
  26. STATISTICAL METHOD TO CONTROL THE HEALTHY WORKER EFFECT
    James Robins; Fiscal Year: 1990
    ..of arsenic-exposed copper smelter workers, solvent-exposed rubber workers, formaldehyde- exposed chemical workers, cobalt-exposed hard metal workers. Canadian asbestos miners, U.S...
  27. INTRINSIC NERVES AND REGULATION OF SMALL BOWEL MOTILITY
    Constantine Frantzides; Fiscal Year: 1990
    ..degeneration of the intrinsic nerves of the small intestine by local intra-arterial perfusion of a neurotoxin (cobalt chloride); 2) to study the effects of intrinsic denervation on the myoelectric and motor activity in the fasted ..
  28. RADIOASSAY OF ERYTHROPOIETIN
    GISELA CLEMONS; Fiscal Year: 1991
    ..increased hormone levels associated with stimuli known to increase erythropoiesis, such as bleeding, hypoxia or cobalt administration. This radioimmunoassay shows a significant correlation with the in vivo bioassay for erythropoietin...
  29. REGULATION OF GLUT1 GENE EXPRESSION BY HYPOXIA
    Faramarz Ismail Beigi; Fiscal Year: 2001
    ..have made the novel observation that GLUT1 expression in a number of cell lines is markedly augmented by cobalt(II) chloride [Co(II)], an agent which stimulates the expression of hypoxia-responsive genes; members of this gene ..
  30. REDUCTION OF POLYETHYLENE WEAR IN SURGICAL IMPLANTS
    Piran Sioshansi; Fiscal Year: 1990
    The cobalt-chromium-molybdenum alloy designated standard specification F- 75 by the American Society for Testing and Materials (ASTM) is the most commonly used alloy in orthopedic prostheses for total and partial joint replacement...
  31. Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
    VY M DONG; Fiscal Year: 2013
    ..this project will provide fundamental insights into the use of various catalysts, including rhodium, ruthenium, cobalt, and nickel, for the activation and functionalization of carbon-hydrogen bonds-a long standing challenge in modern ..
  32. MECHANISTIC STUDIES ON A CO2+ DEPENDENT MAP FROM E COLI
    RICHARD HOLZ; Fiscal Year: 2002
    Thee long range goals of this research are to define the reaction mechanism and substrate specificity of the cobalt(II)-dependent methionine aminopeptidase from Escherichia coli (MAP)...
  33. TIME RESOLVED STUDIES OF B12 ENZYMES AN COENZYMES
    ROSEANNE SENSION; Fiscal Year: 2000
    ..The key catalytic element in B12 is a unique carbon-cobalt bond...
  34. STATOCYST-OCULOMOTOR SYSTEM/ADVANCED MARINE INVERTEBRATE
    BERND BUDELMANN; Fiscal Year: 1993
    ..and neuronal and synaptic organization of the receptor epithelia (light and electron microscopy, silver and cobalt staining), (b) to determine the functional characteristics of the receptor cells and afferent units (intra- and ..
  35. CARCINOGENESIS TESTING OF SINTERED POROUS COCRMP IMPLANT
    BENDICHT PAULI; Fiscal Year: 1991
    ..Our preliminary studies suggested that the risk of such tumor development might be attributed to (1) high nickel, cobalt, or chromium contents in the implants; and (2) large implant surface areas, typical of cementless porous sintered ..
  36. Micromachined Fluid Transfer Devices for Molecular Screening
    ROBERT HAUSHALTER; Fiscal Year: 2006
    ..in a micromolding process: the silicon FTDs are used to prepare a positive silicon master mold onto which a nickel-cobalt alloy is electrodeposited (i.e...
  37. NMR OF HIV REVERSE TRANSCRIPTASE PRIMERS
    DARRELL DAVIS; Fiscal Year: 2004
    ..coli and human tRNALYS3. Paramagnetic manganese relaxation studies and NOE measurements of cobalt hexanimine complexed with the tRNA hairpins will be used as analogs of the magnesium ions that we have shown bind ..
  38. Toxicant-Induced Nuclear Translocation of Thioredoxin
    WALTER WATSON; Fiscal Year: 2005
    ..to known inducers of Trx translocation (cytokines, phorbol esters, ultraviolet light and ionizing radiation, cobalt chloride, and hypoxia)...
  39. BINUCLEAR MIXED-METAL DERIVATIVES OF TYROSINASE
    KENNETH STROTHKAMP; Fiscal Year: 1991
    ..A method of preparing unique mixed-metal derivatives containing one copper ion and either a cobalt or zinc ion in the binuclear site has been developed...
  40. HOW DO ENZYMES GENERATE AND CONTROL FREE RADICALS
    E Marsh; Fiscal Year: 1999
    ..catalyzed? Adenosylcobalamin serves as a source of adenosyl radical that is unmasked by homolysis of its weak cobalt-carbon bond...
  41. Catalytic Asymmetric Synthesis of Vinyl Chromans Using Palladium(II) Catalysts
    ANGELA CHRISTINE OLSON; Fiscal Year: 2010
    ..substitution chemistry of trichloroacetimidates using a tethered phenol nucleophile will be examined using chiral cobalt oxazoline palladium(ll) catalysts...
  42. SPECTROSCOPIC STUDIES OF ENZYME/SUBSTRATE COMPLEXES
    George Reed; Fiscal Year: 2007
    ..These enzymes use AdoCbl to initiate the radical-mediated rearrangement through homolysis of the cobalt-carbon bond of AdoCbl to give cob(ll)alamin and the reactive 5'-deoxyadenosyl radical...
  43. B12 Biosysthesis and Anaerobic Metabolism in Salmonella
    JORGE ESCALANTE; Fiscal Year: 2009
    ..conversion of the vitamin to the coenzymic form requires the formation of a unique organometallic bond between the cobalt atom of B12 and the adenosyl group from ATP...
  44. Supraspinal Modulation of Neuropathic Pain
    Bradley Taylor; Fiscal Year: 2007
    ..activity in the LC with the microinjection of either a local anesthetic (lidocaine) or a synaptic inhibitor (cobalt) will decrease the tactile and cold hypersensitivity that develops following transection of the tibial and common ..
  45. BIOCONJUGATE DERIVATIVES OF COENZYMES B-12
    CHARLES GRISSOM; Fiscal Year: 2000
    ..Drug-B12 bioconjugates are synthesized by attaching various cytotoxic warheads to the cobalt atom of cobalamin or a structurally-related corrinoid...
  46. H-Tunneling in Methylmalonyl-CoA Mutase
    Ruma Banerjee; Fiscal Year: 2004
    ..A few years ago, we bad reported a novel and anomalously large kinetic isotope effect on the cleavage of the cobalt carbon bond of the cofactor when an isotopic substitution from protium to deuterium was made in the substrate...
  47. Ultra Low Profile Coronary Stent Delivery Catheter
    ALAN ZAMORE; Fiscal Year: 2006
    ..We will mount a commercially available stent, such as the Medtronic "Racer" cobalt-chromium stent in order to test our catheter device...
  48. INTERACTION OF A AND B CHAINS OF HEMOGLOBIN
    Enrico Bucci; Fiscal Year: 1993
    ..The influence of the metal atom will be investigated using mangano-, zinc-, and cobalt- hemoglobins...
  49. CHEMISTRY OF COBALT-DIENE AND ACETYLENE COMPLEXES
    KENNETH NICHOLAS; Fiscal Year: 1992
    Our broad objectives are to explore new reaction chemistry of three classes of cobalt complexes (propargylium)Co2(CO)6-nLn+BF4-(1), (propargylium)Co4(CO)10BF4(2), and (diene)Co(CO)3-nLn(3) in order to establish their patterns of ..
  50. STRUCTURE-FUNCTION STUDIES ON NITRILE HYDRATASE MODELS
    PRADIP MASCHARAK; Fiscal Year: 2003
    ..Although the donor groups around iron (and cobalt) at the active site of the NHases have been identified by spectroscopic techniques and in one case by ..
  51. Graphene-FeCo Nanocrystals for Highly Sensitive MRI, Cancer Imaging and Therapy
    Hongjie Dai; Fiscal Year: 2009
    ..Crystalline iron-cobalt (FeCo) alloy exhibits the highest saturation magnetization among all materials, but has not been used for ..
  52. PARAMAGNETIC IONS USE IN NMR STRUCTURE DETERMINATION
    Miriam Gochin; Fiscal Year: 1999
    ..1) DNA oligomer complexed with cobalt and chromomycin will be investigated...
  53. Molecular Mechanisms of the Hypoxic Response
    Frank Lee; Fiscal Year: 2006
    ..Under conditions such as hypoxia or cobalt (a hypoxia mimic), this unusual modification is inhibited, allowing HIF-1 alpha to escape VHL-mediated degradation...
  54. MECHANISMS OF BIOLOGICAL REDOX REACTIONS OF COPPER
    James Hurst; Fiscal Year: 1980
    ..Am. Chem. Soc., 95, 1703 (1973); ibid., 97, 2654 (1975) on the spectra and electron transfer reactions of cobalt (III)-copper (I) dimers containing copper pi-coordinated to cobalt alkenoate ligands...
  55. STRUCTURAL AND REACTIVITY OF IRON AND COBALT COMPLEXES
    VIRGIL GOEDKEN; Fiscal Year: 1980
    ..is the synthesis, characterization and study of the reactivity of a broad class of metal complexes of iron and cobalt (and their congeners ruthenium and rhodium) which may serve as models for their naturally occurring biological ..
  56. OXYGEN SENSING IN EUKARYOTIC CELLS
    Mark Goldberg; Fiscal Year: 2000
    ..and the glucose transporters GLUT1 and GLUT3, has also been shown to be upregulated by the transition metals cobalt, nickel, and manganese. Little is known about the oxygen (02) sensing pathway(s) which mediate this regulation...
  57. ENZYMES INVOLVED IN COENZYME B12 SYNTHESIS
    Ivan Rayment; Fiscal Year: 2002
    ..It contains a corrin ring system with a central cobalt ion octahedrally coordinated by the four pyrrole nitrogens of the corrin and two axial ligands...
  58. PROTEIN FOLDING USING PARAMAGNETIC DERIVED RESTRAINTS
    PAUL ROSEVEAR; Fiscal Year: 2004
    ..Initially, the zinc finger domain of the retroviral gag protein will be used. This peptide binds both zinc and cobalt with high affinity. The zinc finger domain is fused to either the or C- terminus of the target protein...
  59. MULTI-ROD VARIABLE COLLIMATOR FOR RADIATION THERAPY
    GABE BLOSSER; Fiscal Year: 1991
    ..of a new type of shaped field collimator system to mount on existing oncology therapy linear accelerators and cobalt units...
  60. CONFORMATIONAL KINETICS OF BIOLOGICAL MOLECULES
    Frank Ferrone; Fiscal Year: 1992
    ..The use of cobalt-iron hybrids will reveal how metal substitution affects the quaternary structure change kinetics...
  61. Bioreactivity Markers in Total Hip Replacments
    Nadim Hallab; Fiscal Year: 2004
    ..Additionally, variable immunologic responses induced by implant degradation products (i.e. lymphocyte response to metal ions and monocyte/macrophage response to particulate debris) will be correlated with the development of osteolysis ..
  62. MECHANISM OF ENZYME MEDIATED ACTIVATION OF COENZYME B12
    Kenneth Brown; Fiscal Year: 2005
    ..enzyme requiring 5'-deoxy-adenosylcobalamin (AdoCbl, coenzyme B12) accelerates the rate of homolysis of the carbon-cobalt bond of AdoCbl by 9 to 12 orders of magnitude...
  63. Biomaterials as Decorporation Agents for Radionuclides
    TATIANA LEVITSKAIA; Fiscal Year: 2008
    ..abstract_text> ..