sulfur

Summary

Summary: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight 32.066. It is found in the amino acids cysteine and methionine.

Top Publications

  1. ncbi Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated bacterial phyla
    Kelly C Wrighton
    Department of Earth and Planetary Science, University of California, Berkeley, Berkeley, CA 94720, USA
    Science 337:1661-5. 2012
  2. ncbi Sulfur-doped graphene as an efficient metal-free cathode catalyst for oxygen reduction
    Zhi Yang
    Nanomaterials and Chemistry Key Laboratory, Wenzhou University, Wenzhou, 325027, China
    ACS Nano 6:205-11. 2012
  3. ncbi Elucidation of gene-to-gene and metabolite-to-gene networks in arabidopsis by integration of metabolomics and transcriptomics
    Masami Yokota Hirai
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    J Biol Chem 280:25590-5. 2005
  4. ncbi Biochemistry and molecular biology of lithotrophic sulfur oxidation by taxonomically and ecologically diverse bacteria and archaea
    Wriddhiman Ghosh
    Department of Microbiology, University of Burdwan, West Bengal, India
    FEMS Microbiol Rev 33:999-1043. 2009
  5. pmc The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity
    Lee Macomber
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 106:8344-9. 2009
  6. ncbi 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain
    Norihiro Shibuya
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Kiyose, Tokyo, Japan
    Antioxid Redox Signal 11:703-14. 2009
  7. pmc Cultivation of autotrophic ammonia-oxidizing archaea from marine sediments in coculture with sulfur-oxidizing bacteria
    Byoung Joon Park
    Department of Microbiology, Chungbuk National University, Heungduk gu, Cheongju 361 763, South Korea
    Appl Environ Microbiol 76:7575-87. 2010
  8. ncbi Graphene-wrapped sulfur particles as a rechargeable lithium-sulfur battery cathode material with high capacity and cycling stability
    Hailiang Wang
    Department of Chemistry, Stanford University, Stanford, California 94305, United States
    Nano Lett 11:2644-7. 2011
  9. pmc Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway
    R Scott McIsaac
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 23:2993-3007. 2012
  10. ncbi Control of sulfur partitioning between primary and secondary metabolism
    Sarah G Mugford
    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, UK
    Plant J 65:96-105. 2011

Detail Information

Publications361 found, 100 shown here

  1. ncbi Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated bacterial phyla
    Kelly C Wrighton
    Department of Earth and Planetary Science, University of California, Berkeley, Berkeley, CA 94720, USA
    Science 337:1661-5. 2012
    ..Members of OD1 reduce sulfur and may pump protons using archaeal-type hydrogenases...
  2. ncbi Sulfur-doped graphene as an efficient metal-free cathode catalyst for oxygen reduction
    Zhi Yang
    Nanomaterials and Chemistry Key Laboratory, Wenzhou University, Wenzhou, 325027, China
    ACS Nano 6:205-11. 2012
    ..we find that the graphenes doped with the elements, which have the similar electronegativity with carbon such as sulfur and selenium, can also exhibit better catalytic activity than the commercial Pt/C in alkaline media, indicating ..
  3. ncbi Elucidation of gene-to-gene and metabolite-to-gene networks in arabidopsis by integration of metabolomics and transcriptomics
    Masami Yokota Hirai
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    J Biol Chem 280:25590-5. 2005
    ..Metabolomics and transcriptomics data of Arabidopsis grown under sulfur deficiency were combined and analyzed by batch-learning self-organizing mapping...
  4. ncbi Biochemistry and molecular biology of lithotrophic sulfur oxidation by taxonomically and ecologically diverse bacteria and archaea
    Wriddhiman Ghosh
    Department of Microbiology, University of Burdwan, West Bengal, India
    FEMS Microbiol Rev 33:999-1043. 2009
    Lithotrophic sulfur oxidation is an ancient metabolic process. Ecologically and taxonomically diverged prokaryotes have differential abilities to utilize different reduced sulfur compounds as lithotrophic substrates...
  5. pmc The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity
    Lee Macomber
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 106:8344-9. 2009
    ..Indeed, copper treatment rapidly inactivated isopropylmalate dehydratase, an iron-sulfur cluster enzyme in this pathway. Other enzymes in this iron-sulfur dehydratase family were similarly affected...
  6. ncbi 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain
    Norihiro Shibuya
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Kiyose, Tokyo, Japan
    Antioxid Redox Signal 11:703-14. 2009
    ..In addition, 3MST is localized to neurons, and the levels of bound sulfane sulfur, the precursor of H(2)S, are greatly increased in the cells expressing 3MST and CAT but not increased in cells ..
  7. pmc Cultivation of autotrophic ammonia-oxidizing archaea from marine sediments in coculture with sulfur-oxidizing bacteria
    Byoung Joon Park
    Department of Microbiology, Chungbuk National University, Heungduk gu, Cheongju 361 763, South Korea
    Appl Environ Microbiol 76:7575-87. 2010
    ..rRNA and amoA gene sequence identities to the latter, respectively) were substantially enriched by coculture with sulfur-oxidizing bacteria (SOB)...
  8. ncbi Graphene-wrapped sulfur particles as a rechargeable lithium-sulfur battery cathode material with high capacity and cycling stability
    Hailiang Wang
    Department of Chemistry, Stanford University, Stanford, California 94305, United States
    Nano Lett 11:2644-7. 2011
    We report the synthesis of a graphene-sulfur composite material by wrapping poly(ethylene glycol) (PEG) coated submicrometer sulfur particles with mildly oxidized graphene oxide sheets decorated by carbon black nanoparticles...
  9. pmc Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway
    R Scott McIsaac
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 23:2993-3007. 2012
    In yeast, the pathways of sulfur assimilation are combinatorially controlled by five transcriptional regulators (three DNA-binding proteins [Met31p, Met32p, and Cbf1p], an activator [Met4p], and a cofactor [Met28p]) and a ubiquitin ligase ..
  10. ncbi Control of sulfur partitioning between primary and secondary metabolism
    Sarah G Mugford
    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, UK
    Plant J 65:96-105. 2011
    b>Sulfur is an essential nutrient for all organisms. Plants take up most sulfur as inorganic sulfate, reduce it and incorporate it into cysteine during primary sulfate assimilation...
  11. pmc Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes
    Daili J A Netz
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat Marburg, Marburg, Germany
    Nat Chem Biol 8:125-32. 2012
    ..Together, our findings show that the function of eukaryotic replicative DNA polymerases crucially depends on different metallocenters for accessory subunit recruitment and replisome stability...
  12. ncbi Inorganic sulfur oxidizing system in green sulfur bacteria
    Hidehiro Sakurai
    Research Institute for Photosynthetic Hydrogen Production, Kanagawa University, Hiratsuka, Kanagawa, Japan
    Photosynth Res 104:163-76. 2010
    Green sulfur bacteria use various reduced sulfur compounds such as sulfide, elemental sulfur, and thiosulfate as electron donors for photoautotrophic growth...
  13. ncbi A cryptic sulfur cycle in oxygen-minimum-zone waters off the Chilean coast
    Don E Canfield
    Institute of Biology and Nordic Center for Earth Evolution, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Science 330:1375-8. 2010
    ..This cryptic sulfur cycle is linked to anammox and other nitrogen cycling processes, suggesting that it may influence biogeochemical ..
  14. ncbi The versatile epsilon-proteobacteria: key players in sulphidic habitats
    Barbara J Campbell
    College of Marine Studies, University of Delaware, Lewes, Delaware 19958, USA
    Nat Rev Microbiol 4:458-68. 2006
    ..These integrated perspectives provide a framework for future culture- and genomic-based studies...
  15. ncbi Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions
    Yoshiho Ikeuchi
    Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Mol Cell 21:97-108. 2006
    ..The desulfurase activity of IscS is stimulated by TusA binding. IscS transfers the persulfide sulfur to TusA. TusE binds TusBCD complex and stimulates sulfur transfer from TusA to TusD...
  16. ncbi Sulfonate-sulfur metabolism and its regulation in Escherichia coli
    J R van der Ploeg
    Institut fur Mikrobiologie, Swiss Federal Institute of Technology, ETH Zentrum, 8092 Zurich, Switzerland
    Arch Microbiol 176:1-8. 2001
    In the absence of sulfate and cysteine, Escherichia coli can use aliphatic sulfonates as a source of sulfur for growth. Starvation for sulfate leads to the expression of the tauABCD and ssuEADCB genes...
  17. pmc E1- and ubiquitin-like proteins provide a direct link between protein conjugation and sulfur transfer in archaea
    Hugo V Miranda
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611 0700, USA
    Proc Natl Acad Sci U S A 108:4417-22. 2011
    ..required for the formation of these Ubl-protein conjugates (SAMPylation) and whether this system is linked to sulfur transfer. Markerless in-frame deletions were generated in H. volcanii target genes...
  18. ncbi Anaerobic sulfur oxidation in the absence of nitrate dominates microbial chemoautotrophy beneath the pelagic chemocline of the eastern Gotland Basin, Baltic Sea
    Günter Jost
    Department of Biological Oceanography, Leibniz Institute for Baltic Sea Research, Rostock Warnemünde, Germany
    FEMS Microbiol Ecol 71:226-36. 2010
    ..harbor significant numbers and activity of chemolithoautotrophic microorganisms, known to oxidize reduced sulfur or nitrogen species...
  19. ncbi Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease
    Paul G Winyard
    Peninsula Medical School, University of Exeter, St Luke s Campus, Exeter EX1 2LU, UK
    Biochem Soc Trans 39:1226-32. 2011
    Reactive species of oxygen, nitrogen and sulfur play cell signalling roles in human health, e.g...
  20. pmc Furfural inhibits growth by limiting sulfur assimilation in ethanologenic Escherichia coli strain LY180
    Elliot N Miller
    Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida 3261, USA
    Appl Environ Microbiol 75:6132-41. 2009
    ..Supplementation with other reduced sulfur sources such as d-cysteine and thiosulfate also increased furfural tolerance...
  21. ncbi Iron-sulfur cluster sensor-regulators
    Jason C Crack
    Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Curr Opin Chem Biol 16:35-44. 2012
    Regulatory proteins that contain an iron-sulfur cluster cofactor constitute a group that is growing both in number and importance, with a range of functions that include sensing of molecular oxygen, stress response, and iron regulation...
  22. ncbi Metaproteogenomic analysis of a dominant green sulfur bacterium from Ace Lake, Antarctica
    Charmaine Ng
    School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia
    ISME J 4:1002-19. 2010
    Green sulfur bacteria (GSB) (Chlorobiaceae) are primary producers that are important in global carbon and sulfur cycling in natural environments...
  23. pmc Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions
    Akiko Noma
    Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Bldg 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Nucleic Acids Res 37:1335-52. 2009
    ..An in vitro sulfur transfer experiment revealed that Tum1p stimulated the cysteine desulfurase of Nfs1p, and accepted persulfide ..
  24. ncbi Enzymatic activation of sulfur for incorporation into biomolecules in prokaryotes
    Dorothea Kessler
    Biochemiezentrum Heidelberg, Universitat Heidelberg, Heidelberg, Germany
    FEMS Microbiol Rev 30:825-40. 2006
    b>Sulfur is a functionally important element of living matter. Incorporation into biomolecules occurs by two basic strategies...
  25. ncbi Sulfur assimilation in photosynthetic organisms: molecular functions and regulations of transporters and assimilatory enzymes
    Hideki Takahashi
    RIKEN Plant Science Center, Yokohama 230 0045, Japan
    Annu Rev Plant Biol 62:157-84. 2011
    b>Sulfur is required for growth of all organisms and is present in a wide variety of metabolites having distinctive biological functions...
  26. pmc Comparative metagenomics of microbial communities inhabiting deep-sea hydrothermal vent chimneys with contrasting chemistries
    Wei Xie
    China UK HUST RRes Genetic Engineering and Genomics Joint Laboratory, Huazhong University of Science and Technology, Wuhan, PR China
    ISME J 5:414-26. 2011
    ..of the metabolic pathways revealed that the microbial community in the wall of chimney 4143-1 was mainly fueled by sulfur oxidation, putatively coupled to nitrate reduction to perform inorganic carbon fixation through the Calvin-Benson-..
  27. pmc Combinatorial control of diverse metabolic and physiological functions by transcriptional regulators of the yeast sulfur assimilation pathway
    Allegra A Petti
    The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 23:3008-24. 2012
    ..bioinformatic methods, we found that these regulators control genes involved in biological processes downstream of sulfur assimilation; many of these processes had not previously been documented as methionine dependent...
  28. pmc Fe-S cluster assembly pathways in bacteria
    Carla Ayala-Castro
    Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA
    Microbiol Mol Biol Rev 72:110-25, table of contents. 2008
    Iron-sulfur (Fe-S) clusters are required for critical biochemical pathways, including respiration, photosynthesis, and nitrogen fixation...
  29. pmc Coral-associated bacteria and their role in the biogeochemical cycling of sulfur
    Jean Baptiste Raina
    Australian Institute of Marine Science, Townsville MC, Queensland, Australia
    Appl Environ Microbiol 75:3492-501. 2009
    ..coral tissues although, to date, there have been no investigations into the influence of these organic sulfur compounds on coral-associated bacteria...
  30. pmc Isolation, characterization, and ecology of sulfur-respiring crenarchaea inhabiting acid-sulfate-chloride-containing geothermal springs in Yellowstone National Park
    Eric S Boyd
    Department of Microbiology, Montana State University, 109 Lewis Hall, Bozeman, MT 59717, USA
    Appl Environ Microbiol 73:6669-77. 2007
    Elemental sulfur (S(0)) is associated with many geochemically diverse hot springs, yet little is known about the phylogeny, physiology, and ecology of the organisms involved in its cycling...
  31. ncbi Cadmium at high dose perturbs growth, photosynthesis and nitrogen metabolism while at low dose it up regulates sulfur assimilation and antioxidant machinery in garden cress (Lepidium sativum L.)
    Sarvajeet Singh Gill
    Plant Physiology and Biochemistry Division, Department of Botany, Aligarh Muslim University, Aligarh 202 002, India
    Plant Sci 182:112-20. 2012
    ..6.1) activity and nitrogen (N) content was also observed. However, ATP-sulfurylase (ATP-S; EC. 2.7.7.4) activity, sulfur (S) content and activities of antioxidant enzymes such as superoxide dismutase (SOD; E.C. 1.15.1...
  32. ncbi Large sulfur isotope fractionation does not require disproportionation
    Min Sub Sim
    Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 333:74-7. 2011
    The composition of sulfur isotopes in sedimentary sulfides and sulfates traces the sulfur cycle throughout Earth's history...
  33. pmc Evidence for hydrogen oxidation and metabolic plasticity in widespread deep-sea sulfur-oxidizing bacteria
    Karthik Anantharaman
    Department of Earth and Environmental Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 110:330-5. 2013
    ..Ammonia and sulfur have been identified as potential electron donors for this chemosynthesis, but they do not fully account for ..
  34. pmc The regulation of sulfur metabolism in Mycobacterium tuberculosis
    Stavroula K Hatzios
    Department of Chemistry, University of California, Berkeley, Berkeley, California, United States of America
    PLoS Pathog 7:e1002036. 2011
    ..The sulfate assimilation pathway of Mtb produces a number of sulfur-containing metabolites with important contributions to pathogenesis and survival...
  35. pmc Sulphur flux through the sulphate assimilation pathway is differently controlled by adenosine 5'-phosphosulphate reductase under stress and in transgenic poplar plants overexpressing gamma-ECS, SO, or APR
    Ursula Scheerer
    Albert Ludwigs University Freiburg, Institute of Forest Botany and Tree Physiology, Chair of Tree Physiology, Georges Köhler Allee 053 054, Freiburg, Germany
    J Exp Bot 61:609-22. 2010
    ..A possible loss of control under certain conditions, that is Cd treatment, Acetochlor treatment, and in APR overexpressing poplar, is discussed...
  36. pmc Cytosolic iron-sulfur cluster assembly (CIA) system: factors, mechanism, and relevance to cellular iron regulation
    Anil K Sharma
    Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 285:26745-51. 2010
    ..This minireview summarizes the present understanding of the cytosolic iron-sulfur cluster assembly (CIA) system in eukaryotes, with a focus on information gained from studies in budding yeast and ..
  37. ncbi Antioxidant and anticancer properties and mechanisms of inorganic selenium, oxo-sulfur, and oxo-selenium compounds
    Ria R Ramoutar
    Chemistry Department, Clemson University, Clemson, SC 29634, USA
    Cell Biochem Biophys 58:1-23. 2010
    Inorganic selenium and oxo-sulfur compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer properties...
  38. ncbi Additional role of O-acetylserine as a sulfur status-independent regulator during plant growth
    Hans Michael Hubberten
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, Potsdam Golm, Germany
    Plant J 70:666-77. 2012
    O-acetylserine (OAS) is one of the most prominent metabolites whose levels are altered upon sulfur starvation. However, its putative role as a signaling molecule in higher plants is controversial...
  39. pmc Effect of mineral sulphur availability on nitrogen and sulphur uptake and remobilization during the vegetative growth of Brassica napus L
    M Abdallah
    UMR INRA UCBN 950 Ecophysiologie Végétale, Agronomie et Nutritions N, C, S EVA, Institut National de la Recherche Agronomique, University of Caen, Caen, France
    J Exp Bot 61:2635-46. 2010
    ..During S limitation, oilseed rape is able to recycle endogenous S compounds (mostly sulphate) from leaves to roots. However, this physiological adaptation may be effective only over a short time scale (i.e. vegetative growth)...
  40. pmc Key role of cysteine residues in catalysis and subcellular localization of sulfur oxygenase-reductase of Acidianus tengchongensis
    Zhi Wei Chen
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    Appl Environ Microbiol 71:621-8. 2005
    Analysis of known sulfur oxygenase-reductases (SORs) and the SOR-like sequences identified from public databases indicated that they all possess three cysteine residues within two conserved motifs (V-G-P-K-V-C(31) and C(101)-X-X-C(104); ..
  41. ncbi Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster
    Ulrich Muhlenhoff
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat Marburg, 35032 Marburg, Germany
    Cell Metab 12:373-85. 2010
    ..Collectively, our study uncovers an important role of monothiol glutaredoxins in cellular iron metabolism, with a surprising connection to cellular redox and sulfur metabolisms.
  42. ncbi Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex
    Chi Lin Tsai
    Department of Chemistry, Texas A and M University, College Station, TX 77842, USA
    Biochemistry 49:9132-9. 2010
    ..Together, these results indicate human frataxin functions with Fe(2+) as an allosteric activator that triggers sulfur delivery and Fe-S cluster assembly...
  43. ncbi Riding the sulfur cycle--metabolism of sulfonates and sulfate esters in gram-negative bacteria
    M A Kertesz
    Institute of Microbiology, Swiss Federal Institute of Technology, ETH Zentrum, CH 8092, Zurich, Switzerland
    FEMS Microbiol Rev 24:135-75. 2000
    Sulfonates and sulfate esters are widespread in nature, and make up over 95% of the sulfur content of most aerobic soils...
  44. pmc Characterization of an autotrophic sulfide-oxidizing marine Arcobacter sp. that produces filamentous sulfur
    C O Wirsen
    Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    Appl Environ Microbiol 68:316-25. 2002
    A coastal marine sulfide-oxidizing autotrophic bacterium produces hydrophilic filamentous sulfur as a novel metabolic end product...
  45. pmc Drug targets in mycobacterial sulfur metabolism
    Devayani P Bhave
    Chemical Biology Ph D Program, University of Michigan, Ann Arbor, Michigan, 48109 2216, USA
    Infect Disord Drug Targets 7:140-58. 2007
    ..b>Sulfur metabolic pathways are essential for survival and the expression of virulence in many pathogenic bacteria, ..
  46. pmc A heteromeric complex containing the centromere binding factor 1 and two basic leucine zipper factors, Met4 and Met28, mediates the transcription activation of yeast sulfur metabolism
    L Kuras
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, France
    EMBO J 15:2519-29. 1996
    Transcription activation of sulfur metabolism in yeast is dependent on two DNA binding factors, the centromere binding factor 1 (Cbf1) and Met4...
  47. ncbi Repair of oxidized iron-sulfur clusters in Escherichia coli
    Ouliana Djaman
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 279:44590-9. 2004
    ..Because sulfur mobilization should be required only if clusters degrade beyond the [3Fe-4S]1+ state, we used whole cell EPR to ..
  48. pmc Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola
    Barbara J Campbell
    University of Delaware, Lewes, Delaware, USA
    PLoS Genet 5:e1000362. 2009
    ..for life in the extreme conditions widely believed to reflect those in the Archaean biosphere--anaerobic, sulfur, H2- and CO2-rich, with fluctuating redox potentials and temperatures...
  49. pmc A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella
    Tiegang Xu
    Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China
    Nucleic Acids Res 38:7133-41. 2010
    ..As in the case of methylation-specific restriction systems, targeted inactivation of this gene cluster should facilitate genetic manipulation of these bacteria, as we demonstrate in Salmonella...
  50. pmc Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast
    Mark J Hickman
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 22:4192-204. 2011
    A yeast strain lacking Met4p, the primary transcriptional regulator of the sulfur assimilation pathway, cannot synthesize methionine...
  51. ncbi Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA
    Sebastian Leidel
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Nature 458:228-32. 2009
    ..Finally, functional analysis reveals that the thiolation function of Urm1p is critical to regulate cellular responses to nutrient starvation and oxidative stress conditions, most likely by increasing translation fidelity...
  52. pmc H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
    Taurai Chiku
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 284:11601-12. 2009
    ..Excessive H(2)S production in hyperhomocysteinemia may contribute to the associated cardiovascular pathology...
  53. pmc Community genomic analysis of an extremely acidophilic sulfur-oxidizing biofilm
    Daniel S Jones
    Department of Geosciences, The Pennsylvania State University, University Park, PA, USA
    ISME J 6:158-70. 2012
    ..population is autotrophic (ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), carboxysomes) and oxidizes sulfur by the sulfide-quinone reductase and sox pathways...
  54. ncbi Sulfur assimilation and glutathione metabolism under cadmium stress in yeast, protists and plants
    David Mendoza-Cozatl
    Departamento de Bioquimica, Instituto Nacional de Cardiologia, Juan Badiano 1, Col Seccion XVI Tlalpan, Mexico
    FEMS Microbiol Rev 29:653-71. 2005
    ..is usually present at high concentrations in most living cells, being the major reservoir of non-protein reduced sulfur. Because of its unique redox and nucleophilic properties, GSH serves in bio-reductive reactions as an important ..
  55. pmc Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions
    Rong Shi
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    PLoS Biol 8:e1000354. 2010
    The cysteine desulfurase IscS is a highly conserved master enzyme initiating sulfur transfer via persulfide to a range of acceptor proteins involved in Fe-S cluster assembly, tRNA modifications, and sulfur-containing cofactor biosynthesis...
  56. ncbi Prokaryotic sulfur oxidation
    Cornelius G Friedrich
    Department of Biochemical and Chemical Engineering, University of Dortmund, D 44221 Dortmund, Germany
    Curr Opin Microbiol 8:253-9. 2005
    Recent biochemical and genomic data differentiate the sulfur oxidation pathway of Archaea from those of Bacteria...
  57. ncbi Raman microspectrometry sulfur detection and characterization in the marine ectosymbiotic nematode Eubostrichus dianae (Desmodoridae, Stilbonematidae)
    David Himmel
    GTSI Université des Antilles et de la Guyane, UFR des Sciences Exactes et Naturelles, Département de Physique B P 592 97159 Pointe à Pitre Cedex, Guadeloupe, France
    Biol Cell 101:43-54. 2009
    ..belonging to the Stilbonematidae (Desmodoridae) family are described as living in obligatory association with sulfur-oxidizing chemoautotrophic ectosymbionts...
  58. pmc An iron-sulfur cluster is essential for the binding of broken DNA by AddAB-type helicase-nucleases
    Joseph T P Yeeles
    DNA Protein Interactions Unit, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 284:7746-55. 2009
    ..we show that the AddB subunit contains a novel class of nuclease domain distinguished by the presence of an iron-sulfur cluster...
  59. ncbi The Aspergillus nidulans metR gene encodes a bZIP protein which activates transcription of sulphur metabolism genes
    Renata Natorff
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5A Pawińskiego Str, 02 106 Warszawa, Poland
    Mol Microbiol 49:1081-94. 2003
    ....
  60. pmc A role for iron-sulfur clusters in the regulation of transcription factor Yap5-dependent high iron transcriptional responses in yeast
    Liangtao Li
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 287:35709-21. 2012
    ..Yap5 iron sensing, we discovered that a mutation in SSQ1, which encodes a mitochondrial chaperone involved in iron-sulfur cluster synthesis, prevented expression of Yap5 target genes...
  61. ncbi Phylogenetic relationships of Thiomicrospira species and their identification in deep-sea hydrothermal vent samples by denaturing gradient gel electrophoresis of 16S rDNA fragments
    G Muyzer
    Molecular Ecology Unit, Max Planck Institute for Marine Microbiology, Fahrenheitstrasse 1, D 28359 Bremen, Germany
    Arch Microbiol 164:165-72. 1995
    ..the genetic diversity of hydrothermal vent microbial communities, specifically to determine the importance of sulfur-oxidizing bacteria therein...
  62. ncbi Bacterial sulfur cycling shapes microbial communities in surface sediments of an ultramafic hydrothermal vent field
    Regina Schauer
    Max Planck Institute for Marine Microbiology, Celsiusstr 1, D 28359 Bremen, Germany
    Environ Microbiol 13:2633-48. 2011
    ..Temperature profiling at two mat-covered sites showed a conductive heating of the sediments. Elemental sulfur was detected in the overlying mat and metal-sulfides in the upper sediment layer...
  63. pmc Lessons from Escherichia coli genes similarly regulated in response to nitrogen and sulfur limitation
    Prasad Gyaneshwar
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:3453-8. 2005
    ..characterized nutrient-specific transcriptional changes in Escherichia coli upon limitation of nitrogen (N) or sulfur (S). These global homeostatic responses presumably minimize the slowing of growth under a particular condition...
  64. ncbi Regulation of sulfate uptake and assimilation--the same or not the same?
    Jean Claude Davidian
    Unite Mixte de Recherche, Biochimie et Physiologie Moleculaire des Plantes, Montpellier SupAgro CNRS INRA UM2, 2 Place Pierre Viala, 34060 Montpellier Cedex 2, France
    Mol Plant 3:314-25. 2010
    Plant take up the essential nutrient sulfur as sulfate from the soil, reduce it, and assimilate into bioorganic compounds, with cysteine being the first product...
  65. pmc Acidithiobacillus caldus sulfur oxidation model based on transcriptome analysis between the wild type and sulfur oxygenase reductase defective mutant
    Linxu Chen
    State Key Lab of Microbial Technology, Shandong University, Jinan, China
    PLoS ONE 7:e39470. 2012
    ..caldus) is widely used in bio-leaching. It gains energy and electrons from oxidation of elemental sulfur and reduced inorganic sulfur compounds (RISCs) for carbon dioxide fixation and growth...
  66. ncbi Sulfur-driven autotrophic denitrification: diversity, biochemistry, and engineering applications
    Ming Fei Shao
    Department of Civil Engineering, The University of Hong Kong, SAR, China
    Appl Microbiol Biotechnol 88:1027-42. 2010
    b>Sulfur-driven autotrophic denitrification refers to the chemolithotrophic process coupling denitrification with the oxidation of reduced inorganic sulfur compounds...
  67. ncbi Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydA(DeltaEFG)
    David W Mulder
    Astrobiology Biogeocatalysis Research Center, Montana State University, Bozeman, Montana 59717, USA
    Nature 465:248-51. 2010
    ....
  68. pmc Cadmium stress tolerance in crop plants: probing the role of sulfur
    Sarvajeet Singh Gill
    Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology ICGEB, Aruna Asaf Ali Marg, New Delhi, India
    Plant Signal Behav 6:215-22. 2011
    ..b>Sulfur (S) uptake and assimilation are crucial for determining crop yield and resistance to Cd stress...
  69. pmc S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum
    Gaelle André
    Genetics of Bacterial Genomes, Pasteur Institute, CNRS URA2171, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 36:5955-69. 2008
    ..The abundance of sense and antisense transcripts was inversely correlated with the sulfur source availability...
  70. ncbi Novel groups of Gammaproteobacteria catalyse sulfur oxidation and carbon fixation in a coastal, intertidal sediment
    Sabine Lenk
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    Environ Microbiol 13:758-74. 2011
    The oxidation of hydrogen sulfide is essential to sulfur cycling in marine habitats...
  71. pmc Whole-genome shotgun sequencing of the sulfur-oxidizing chemoautotroph Tetrathiobacter kashmirensis
    Wriddhiman Ghosh
    Department of Microbiology, Bose Institute, P 1 12 CIT Scheme VIIM, Kolkata 700054, India
    J Bacteriol 193:5553-4. 2011
    ..While a complete inorganic sulfur oxidation gene cluster, soxCDYZAXWB, is present in its genome, pathogenicity islands or genes associated with ..
  72. ncbi An intestinal parasitic protist, Entamoeba histolytica, possesses a non-redundant nitrogen fixation-like system for iron-sulfur cluster assembly under anaerobic conditions
    Vahab Ali
    Department of Parasitology, National Institute of Infectious Diseases, Tokyo 162 8640
    J Biol Chem 279:16863-74. 2004
    We have characterized the iron-sulfur (Fe-S) cluster formation in an anaerobic amitochondrial protozoan parasite, Entamoeba histolytica, in which Fe-S proteins play an important role in energy metabolism and electron transfer...
  73. ncbi Bacterial cysteine desulfurases: versatile key players in biosynthetic pathways of sulfur-containing biofactors
    Ryota Hidese
    Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan
    Appl Microbiol Biotechnol 91:47-61. 2011
    ..5'-phosphate-dependent homodimeric enzymes that catalyze the conversion of L-cysteine to L-alanine and sulfane sulfur via the formation of a protein-bound cysteine persulfide intermediate on a conserved cysteine residue...
  74. ncbi Proteomic and transcriptomic analysis of Arabidopsis seeds: molecular evidence for successive processing of seed proteins and its implication in the stress response to sulfur nutrition
    Yasuhiro Higashi
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Inage Ku, Chiba 263 8522, Japan
    Plant J 48:557-71. 2006
    Seed storage proteins are synthesized as sources of carbon, nitrogen and sulfur for the next generation of plants. Their composition changes according to nutritional conditions...
  75. ncbi Reactive oxygen species production induced by ethanol in Saccharomyces cerevisiae increases because of a dysfunctional mitochondrial iron-sulfur cluster assembly system
    Rocio V Pérez-Gallardo
    Lab de Biotecnología Microbiana, Instituto de Investigaciones Quimico Biologicas, Morelia, Michoacan, Mexico
    FEMS Yeast Res 13:804-19. 2013
    ..The iron-sulfur (Fe-S) cluster biogenesis is encoded by the ISC genes...
  76. ncbi Molecular analysis of the distribution and phylogeny of the soxB gene among sulfur-oxidizing bacteria - evolution of the Sox sulfur oxidation enzyme system
    Birte Meyer
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, D 28359 Bremen, Germany
    Environ Microbiol 9:2957-77. 2007
    ..Sox enzyme complex, which has been proposed to be widespread among the various phylogenetic groups of sulfur-oxidizing bacteria (SOB) that convert thiosulfate to sulfate with and without the formation of sulfur globules as ..
  77. pmc Survey of archaeal diversity reveals an abundance of halophilic Archaea in a low-salt, sulfide- and sulfur-rich spring
    Mostafa S Elshahed
    Department of Botany and Microbiology and Institute for Energy and the Environment, University of Oklahoma, Norman, Oklahoma 73019, USA
    Appl Environ Microbiol 70:2230-9. 2004
    The archaeal community in a sulfide- and sulfur-rich spring with a stream water salinity of 0.7 to 1.0% in southwestern Oklahoma was studied by cloning and sequencing of 16S rRNA genes...
  78. ncbi Niche differentiation among sulfur-oxidizing bacterial populations in cave waters
    Jennifer L Macalady
    Department of Geosciences, Pennsylvania State University, Pennsylvania, PA 16802, USA
    ISME J 2:590-601. 2008
    The sulfidic Frasassi cave system affords a unique opportunity to investigate niche relationships among sulfur-oxidizing bacteria, including epsilonproteobacterial clades with no cultivated representatives...
  79. pmc Sulfur amino acid metabolism and its control in Lactococcus lactis IL1403
    Brice Sperandio
    Génétique Microbienne, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France
    J Bacteriol 187:3762-78. 2005
    ..O-Acetyl serine increases FhuR binding affinity to its binding boxes. The overall view of sulfur amino acid metabolism and its regulation in L...
  80. ncbi Sulfur-metabolizing bacterial populations in microbial mats of the Nakabusa hot spring, Japan
    Kyoko Kubo
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    Syst Appl Microbiol 34:293-302. 2011
    ..analyzed by focusing on the diversity, as well as the in situ distribution and function of bacteria involved in sulfur cycling...
  81. pmc Origin and function of ubiquitin-like proteins
    Mark Hochstrasser
    Yale University, Department of Molecular Biophysics and Biochemistry, 266 Whitney Avenue, PO Box 208114, New Haven, Connecticut 06520, USA
    Nature 458:422-9. 2009
    ....
  82. ncbi Cloning of a cDNA encoded by a member of the Arabidopsis thaliana ATP sulfurylase multigene family. Expression studies in yeast and in relation to plant sulfur nutrition
    H M Logan
    Ecole Nationale Supérieure Agronomique de Montpellier, Institut National de la Recherche Agronomique, CNRS URA 573, France
    J Biol Chem 271:12227-33. 1996
    ..Absence of sulfate from culture media transiently increased B. napus transcript abundance, indicating that initially, the response to sulfate deprivation is transcriptionally regulated...
  83. pmc Deletion strains reveal metabolic roles for key elemental sulfur-responsive proteins in Pyrococcus furiosus
    Stephanie L Bridger
    Department of Biochemistry and Molecular Biology, Life Sciences Bldg, University of Georgia, Athens, GA 30602 7229, USA
    J Bacteriol 193:6498-504. 2011
    ..of Pyrococcus furiosus previously indicated that three proteins play key roles in the metabolism of elemental sulfur (S(0)): a membrane-bound oxidoreductase complex (MBX), a cytoplasmic coenzyme A-dependent NADPH sulfur ..
  84. pmc Gene expression patterns of sulfur starvation in Synechocystis sp. PCC 6803
    Zhigang Zhang
    Biotechnology Institute, 1479 Gortner Avenue, University of Minnesota, St, Paul, MN 55108, USA
    BMC Genomics 9:344. 2008
    ....
  85. pmc Overexpression of serine acetlytransferase produced large increases in O-acetylserine and free cysteine in developing seeds of a grain legume
    Linda Tabe
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT, 2601 Australia
    J Exp Bot 61:721-33. 2010
    ..OAS and free methionine, but not free cysteine, were implicated as signalling metabolites controlling expression of a gene for a cysteine-rich seed storage protein...
  86. pmc Isolation and characterization of a sulfur-oxidizing chemolithotroph growing on crude oil under anaerobic conditions
    Yumiko Kodama
    Marine Biotechnology Institute, Kamaishi Laboratories, Heita, Kamaishi City, Iwate 026 0001, Japan
    Appl Environ Microbiol 69:107-12. 2003
    ..Growth experiments under anaerobic conditions showed that strain YK-1 was a sulfur-oxidizing obligate chemolithotroph utilizing sulfide, elemental sulfur, thiosulfate, and hydrogen as electron ..
  87. pmc SurR regulates hydrogen production in Pyrococcus furiosus by a sulfur-dependent redox switch
    Hua Yang
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Mol Microbiol 77:1111-22. 2010
    ..P. furiosus produces H(2) during fermentation, but undergoes a metabolic shift to produce H(2) S when elemental sulfur (S(0) ) becomes available...
  88. ncbi X-ray Structure of a self-compartmentalizing sulfur cycle metalloenzyme
    Tim Urich
    Darmstadt University of Technology, Institute of Microbiology and Genetics, Schnittspahnstrasse 10, 64287 Darmstadt, Germany
    Science 311:996-1000. 2006
    Numerous microorganisms oxidize sulfur for energy conservation and contribute to the global biogeochemical sulfur cycle. We have determined the 1...
  89. pmc Allochromatium vinosum DsrC: solution-state NMR structure, redox properties, and interaction with DsrEFH, a protein essential for purple sulfur bacterial sulfur oxidation
    John R Cort
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    J Mol Biol 382:692-707. 2008
    Sequenced genomes of dissimilatory sulfur-oxidizing and sulfate-reducing bacteria containing genes coding for DsrAB, the enzyme dissimilatory sulfite reductase, inevitably also contain the gene coding for the 12-kDa DsrC protein...
  90. pmc Novel genes of the dsr gene cluster and evidence for close interaction of Dsr proteins during sulfur oxidation in the phototrophic sulfur bacterium Allochromatium vinosum
    Christiane Dahl
    Institut für Mikrobiologie and Biotechnologie, Rheinische Friedrich Wilhelms Universitat Bonn, Meckenheimer Allee 168, D 53115 Bonn, Germany
    J Bacteriol 187:1392-404. 2005
    ..were identified immediately downstream of dsrABEFHCMK, completing the dsr gene cluster of the phototrophic sulfur bacterium Allochromatium vinosum D (DSM 180(T))...
  91. pmc Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival
    Amit Singh
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11562-7. 2007
    ..Here we show that Mtb WhiB3 responds to the dormancy signals NO and O2 through its iron-sulfur (Fe-S) cluster...
  92. ncbi Functional genes as markers for sulfur cycling and CO2 fixation in microbial communities of hydrothermal vents of the Logatchev field
    Michael Hügler
    Leibniz Institut fur Meereswissenschaften, IFM GEOMAR, Kiel, Germany
    FEMS Microbiol Ecol 73:526-37. 2010
    ..the analysis of 16S rRNA gene sequences with studies of functional key genes involved in biochemical pathways of sulfur oxidation-reduction (soxB, aprA) and autotrophic carbon fixation (aclB, cbbM, cbbL)...
  93. ncbi Sulfur metabolism: a versatile platform for launching defence operations
    Thomas Rausch
    Heidelberg Institute of Plant Sciences HIP, INF 360, D 69120 Heidelberg, Germany
    Trends Plant Sci 10:503-9. 2005
    b>Sulfur-containing defence compounds (SDCs) are crucial for the survival of plants under biotic and abiotic stress...
  94. pmc Hydrogen production in Chlamydomonas: photosystem II-dependent and -independent pathways differ in their requirement for starch metabolism
    Vincent Chochois
    Commissariat a l Energie Atomique, Direction des Sciences du Vivant, Institut de Biologie Environnementale et de Biotechnologie, Laboratoire de Bioénergétique et Biotechnologie des Bactéries et Microalgues, Commissariat à l Energie Atomique Cadarache, F 13108 Saint Paul lez Durance, France
    Plant Physiol 151:631-40. 2009
    Under sulfur deprivation conditions, the green alga Chlamydomonas reinhardtii produces hydrogen in the light in a sustainable manner thanks to the contribution of two pathways, direct and indirect...
  95. pmc RNA-seq analysis of sulfur-deprived Chlamydomonas cells reveals aspects of acclimation critical for cell survival
    David Gonzalez-Ballester
    Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA
    Plant Cell 22:2058-84. 2010
    The Chlamydomonas reinhardtii transcriptome was characterized from nutrient-replete and sulfur-depleted wild-type and snrk2.1 mutant cells. This mutant is null for the regulatory Ser-Thr kinase SNRK2...
  96. pmc Phylogenetic diversity and spatial distribution of the microbial community associated with the Caribbean deep-water sponge Polymastia cf. corticata by 16S rRNA, aprA, and amoA gene analysis
    Birte Meyer
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, 28359, Bremen, Germany
    Microb Ecol 56:306-21. 2008
    ..Consistently, the aprA and amoA gene-based analyses indicated the presence of environmentally derived sulfur- and ammonia-oxidizers besides putative sponge-specific sulfur-oxidizing Gammaproteobacteria and ..
  97. pmc Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse
    Eric O Uthus
    US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, ND 58202 9034, USA
    Mech Ageing Dev 127:444-50. 2006
    ....
  98. ncbi A functional transsulfuration pathway in the brain links to glutathione homeostasis
    Victor Vitvitsky
    Redox Biology Center, University of Nebraska Lincoln, Lincoln, Nebraska 68588, USA
    J Biol Chem 281:35785-93. 2006
    ..This study establishes the presence of an intact transsulfuration pathway and demonstrates its contribution to glutathione-dependent redox-buffering capacity under ex vivo conditions in brain cells and slices...
  99. ncbi Towards the phylogeny of APS reductases and sirohaem sulfite reductases in sulfate-reducing and sulfur-oxidizing prokaryotes
    W M Hipp
    Institut für Mikrobiologie and Biotechnologie, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Microbiology 143:2891-902. 1997
    The genes for adenosine-5'-phosphosulfate (APS) reductase, aprBA, and sirohaem sulfite reductase, dsrAB, from the sulfur-oxidizing phototrophic bacterium Chromatium vinosum strain D (DSMZ 180(T)) were cloned and sequenced...
  100. ncbi Sulfur in human nutrition and applications in medicine
    Stephen Parcell
    American Institute for Biosocial and Medical Research AIBMR, Tacoma, WA, USA
    Altern Med Rev 7:22-44. 2002
    Because the role of elemental sulfur in human nutrition has not been studied extensively, it is the purpose of this article to emphasize the importance of this element in humans and discuss the therapeutic applications of sulfur compounds ..
  101. ncbi Trichothiodystrophy: update on the sulfur-deficient brittle hair syndromes
    P H Itin
    Department of Dermatology, University of Basel and Kantonsspital Aarau, Switzerland
    J Am Acad Dermatol 44:891-920; quiz 921-4. 2001
    ..of autosomal recessive disorders that share the distinctive features of short, brittle hair and an abnormally low sulfur content. Within the spectrum of the TTD syndromes are numerous interrelated neuroectodermal disorders...

Research Grants70

  1. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..CBS is a metabolic enzyme involved in the metabolism of sulfur containing amino acid such as methionine (Met)...
  2. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..5, PM10, ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide), matched to the exact locations of participants'homes...
  3. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Respirable dust, elemental carbon, black carbon, nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), aldehydes, and polycyclic aromatic hydrocarbons (PAHs) will be sampled from ..
  4. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2013
    ..Its putative normal function is the biogenesis of iron- sulfur (Fe-S) clusters conveying iron homeostasis to the entire cell...
  5. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..revealed over 50 contamination events nationwide attributed to 8 trace elements and heavy metals such as copper, sulfur, lead, arsenic, zinc, selenium and 9 phosphorus...
  6. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2013
    ..cellular processes such as the synthesis of nucleotides and glutathione, metabolism of most amino acids, including sulfur amino acids, methylation processes, and gluconeogenesis...
  7. Safety signal learning in Rhesus monkeys following early life stressChallenge Ar
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..Thus the sound of a car back firing or the smell of sulfur can lead to an intense fear reaction in Viet Nam veterans many years after combat, even in the safety of their own ..
  8. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN JD O'KEEFE; Fiscal Year: 2012
    ..the explanation may lie in the high dietary intake of red meat by AAs which increases microbiota populations of sulfur-reducing bacteria (SRBs), which produce cytotoxic and genotoxic hydrogen sulfide as a terminal product...
  9. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010
    ..In addition, affected subjects have a low intake in sulfur amino acids (SAA) needed to detoxify endogenously produced cyanide (CN)...
  10. Mitochondrial function and antifungal photodynamic therapy
    Constantine G Haidaris; Fiscal Year: 2011
    ..The sulfur containing amino acids cysteine and methionine are primary targets of oxidative damage in proteins...
  11. Air Pollution, Inflammation and Preterm Birth: A Mechanistic Study in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2012
    ..5, PM10, ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide), matched to locations of participants'homes...
  12. Novel therapeutics for vesicants and toxic inhaled chemicals (U54)
    Carl W White; Fiscal Year: 2013
    PROJECT SUMMARY (See instructions): Denver's CounterACT program was formed to develop models of sulfur mustard (SM) toxicity to lung and skin, understand injury pathogenesis, and evaluate novel antioxidants to rescue SM-mediated ..
  13. EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUS
    Richard C Deth; Fiscal Year: 2012
    ..The proposed project will carry out a detailed study of how morphine, methamphetamine, alcohol each affect sulfur metabolism and antioxidant status in cultured human neuroblastoma cells and primary cultured neurons...
  14. Redox regulation in aging and failing heart
    Junichi Sadoshima; Fiscal Year: 2013
    ..O2- inactivates iron-sulfur cluster containing enzymes, thereby liberating free iron, which in turn generates the highly reactive hydroxyl ..
  15. Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity
    Sven Eric Jordt; Fiscal Year: 2013
    ..antagonist increased survival rates of phosgene-exposed mice, and also inhibited vesicant injury induced by the sulfur mustard analog, CEES...
  16. Detoxification of Electrophilic Chemical Threat Agents by Nucleophilic Scavengers
    Michael C MacLeod; Fiscal Year: 2010
    One class of chemical threat agents for which medical countermeasures must be developed, the sulfur and nitrogen mustards (SNMs), exert their toxic effects through chemical reactions that involve an electrophilic intermediate...
  17. Regulation of Streptomyces differentiation and antibiotic production by SoxR
    Monica Chander; Fiscal Year: 2010
    ..Together, these experiments will provide further insight into redox-sensing and transduction mechanisms by iron-sulfur regulatory proteins...
  18. A Comparative Approach to Globin Regulation/Thalassemia
    LEONARD IRA ZON; Fiscal Year: 2012
    ..These factors fall into four categories: the production of heme, iron utilization, globin expression, and iron sulfur cluster production...
  19. Re-Wiring Cellular Metabolism to Control Biofilm Formation and Virulence BY...
    Thomas K Wood; Fiscal Year: 2011
    ..we will use a simple model system (pathogenic and non-pathogenic Escherichia coli along with pseudomonads and sulfur-reducing bacteria) that allows us to investigate biofilm formation and virulence in a realistic environment (i.e...
  20. ROLE OF B.FRAGILIS OXYGEN STRESS RESPONSE IN INFECTION
    Charles J Smith; Fiscal Year: 2013
    ..We will determine if the iron storage proteins can contribute to the repair of iron sulfur proteins and the in vivo expression of their cognate genes will be measured to gain insight into their role during ..
  21. Utilization of calcite for the reduction of coal mine dust toxicity
    Xi Huang; Fiscal Year: 2010
    ..CaCO3) is widely used to prevent explosions, treat acid mine drainage, and absorb acid rain components such as sulfur dioxide released during combustion...
  22. Pilot-Scale Heterocyclic and Carbocyclic Libraries for High Throughout Screening
    RICHARD LAROCK; Fiscal Year: 2009
    ..2) The cyclization of readily available, functionally-substituted alkynes by halogen, sulfur, selenium and organopalladium electrophiles will be utilized to prepare libraries of medicinally interesting ..
  23. Soft Metal, Disulfide, and Cysteine Stresses in Escherichia coli
    James A Imlay; Fiscal Year: 2013
    ..It does so by binding the cysteine residues that coordinate the catalytic iron-sulfur clusters of these enzymes, thereby displacing the iron atoms...
  24. Fluorescein for Sentinel Lymph Node Detection
    James M McGreevy; Fiscal Year: 2012
    ..receive a SLN biopsy procedure that employs a non-fluorescent blue dye, Lymphazurin(R) and a Tc-99m-radioactive sulfur colloid preparation...
  25. Molecular Genetics of Sideroblastic Anemia
    Mark D Fleming; Fiscal Year: 2013
    ..Mitochondria are instrumental in the biosynthesis of heme and iron sulfur clusters, which contain iron, and are employed as cofactors in numerous proteins, including hemoglobin, the ..
  26. Study of an iron-responsive E3 ligase regulating mammalian iron homeostasis
    Richard K Bruick; Fiscal Year: 2013
    ..When cellular free iron availability is high, IRP1 assembles an iron-sulfur cluster, causing the protein to lose its affinity for IREs, while IRP2 is preferentially ubiquitinated and ..
  27. Mechanisms of Sulfur Mustard Toxicology
    YIHUA JAN; Fiscal Year: 2010
    ..of our proposed studies is to reveal the molecular mechanisms of cytotoxicity induced by mustard agents such as sulfur mustard (2, 2'-dichlorodiethyl sulfide). Sulfur mustard is a potent vesicant known to damage lung tissue...
  28. Mitochondrial Iron-Sulfur cluster mechanisms and therapy in Friedreich's ataxia
    Gino A Cortopassi; Fiscal Year: 2013
    ..Of those drugs, some increase frataxin expression, whereas others are likely to support iron-sulfur cluster biogenesis...
  29. Studies of Isoprenoid Biosynthesis
    CHARLES DALE POULTER; Fiscal Year: 2013
    ..and thiol-containing analogues of methylerythritol phosphate and hydroxydimethylallyl diphosphate will be synthesized and examined as mechanism-based inhibitors of the iron-sulfur cluster enzymes the methylerythritol phosphate pathway.
  30. Strategies for Heavy Metal Detoxification
    Gerard Parkin; Fiscal Year: 2013
    ..to the cysteine residues of proteins, specific emphasis will be given to the application of ligands that feature sulfur donors...
  31. Novel components of iron sulfur cluster biosynthesis pathways
    Gareth P Butland; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Iron-sulfur (FeS) clusters are ancient ubiquitous metalloprotein cofactors whose origins are thought to lay in the reducing environment of the early anaerobic biosphere...
  32. 2012 Iron Sulfur Enzymes Gordon Research Conference
    Markus W Ribbe; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): This application requests partial support for a meeting on Iron Sulfur Enzymes as part of a the Gordon Research Conference series to be held in Mount Holyoke College (South Hadley, MA) on June 10-15, ..
  33. BIOINORGANIC COPPER COORDINATION CHEMISTRY
    Kenneth D Karlin; Fiscal Year: 2013
    ..In addition, we will explore the possibility that copper active-site chemistry involves methionine sulfur radical cation formation during O2-actvation and enzyme turnover, a new paradigm in the field, (4) direct in-depth ..
  34. The Biological and Chemical Function of Selenium in Enzymes
    Robert J Hondal; Fiscal Year: 2013
    ..of "super-Cys" residue that can "speed reactions" due to selenium's superior chemical reactivity relative to sulfur. If this were true, then we might expect to find the use of Sec widely spread throughout nature instead of its ..
  35. Role of WhiB3 in M. tuberculosis virulence
    ADRIE JC STEYN; Fiscal Year: 2013
    ..the mechanism of this physiological event, we will identify the WhiB3 amino acids necessary for effective iron-sulfur (Fe-S) reconstitution, and use electron paramagnetic resonance spectroscopy (EPR) to characterize these mutated ..
  36. MECHANISM OF MYCOBACTERIUM TUBERCULOSIS PERSISTENCE
    ADRIE JC STEYN; Fiscal Year: 2012
    ..the mechanism of this physiological event, we will identify the WhiB3 amino acids necessary for effective iron-sulfur (Fe-S) reconstitution, and use electron paramagnetic resonance spectroscopy (EPR) to characterize these mutated ..
  37. Parenteral Methionine Requirements in Septic Children
    Leticia Castillo; Fiscal Year: 2013
    ..Morbidity and mortality is higher in these patients. The sulfur amino acids methionine and cysteine are important in critical illness due to methionine role as a methyl group ..
  38. NUTRITIONAL REGULATION OF CYSTEINE DIOXYGENASE
    Martha H Stipanuk; Fiscal Year: 2013
    ..by restricted cysteine, supplemental taurine, or supplemental sulfate, or amplified by diets containing excess sulfur amino acids, low taurine, or low sulfate);(5) to assess the functional contribution of CDO expressed in specific ..
  39. Structure/Function of Complex II Oxidoreductase
    Gary Cecchini; Fiscal Year: 2012
    ..These include a covalently-bound FAD cofactor, three distinct iron- sulfur clusters, a membrane-bound quinone, and a b heme cofactor...
  40. Functions of the Hypoxia-Induced MicroRNA-210 in Pulmonary Vascular Endothelium
    Stephen Y Chan; Fiscal Year: 2013
    ..metabolism and cellular respiration in hypoxic pulmonary arterial endothelial cells, via repression of the iron-sulfur cluster assembly proteins ISCU1/2...
  41. Mitochondrial aconitase: Fe-S cluster biogenesis and interaction with mtDNA
    Debkumar Pain; Fiscal Year: 2012
    ..Saccharomyces cerevisiae mitochondria contain a nucleotide (GTP, NAD(P)H and ATP)- dependent machinery for iron-sulfur cluster (ISC) biogenesis of aconitase (Aco1p)...
  42. Metabolic Engineering Studies of Extreme Thermoacidophily
    Robert M Kelly; Fiscal Year: 2010
    ..or mixotrophically by using both modes, bioenergetics based on dissimilatory oxidation of reduced metal and sulfur species, unique membranes and S-Iayers, and growth stimulation by molecular H2 By strategically integrating some ..
  43. Catalytic Approach to Treatment of Cyanide Poisoning
    SIGRIDUR G SUMAN; Fiscal Year: 2010
    ..Thiosulfate's limited solubility in the liver leads to a slow reaction while facilitating sulfane sulfur transfer to rhodanese...
  44. Coupled Transfers of Electrons and Protons
    James M Mayer; Fiscal Year: 2013
    ..The systems to be examined include phenols, iron porphyrins, ruthenium complexes, and models for iron/sulfur cluster cofactors...
  45. Ubiquitin-like Small Archaeal Protein Modification (SAMPylation)
    Julie A Maupin-Furlow; Fiscal Year: 2013
    ..to have assembled from various prokaryotic pathways that function in related, yet distinct, chemistry such as sulfur activation...
  46. Air Pollution and Children's Cognitive and Health Outcomes
    Ashlesha Datar; Fiscal Year: 2013
    ..of literature has linked exposure to criteria pollutants (particulate matter, ground-level ozone, carbon monoxide, sulfur oxides, nitrogen oxides, and lead) with adverse health outcomes in children, however, much of this literature is ..
  47. Structures &Redox Chemistry in Sulfinic Acid Reduction
    W Todd Lowther; Fiscal Year: 2013
    ..We have shown that Srx utilizes a novel nucleotide binding motif and sulfur chemistry to reduce the Prx molecule and were able to identify critical kinetic intermediates in the repair of ..
  48. ROLE OF B.FRAGILIS OXYGEN STRESS RESPONSE IN INFECTION
    Charles Smith; Fiscal Year: 2009
    ..We will determine if the iron storage proteins can contribute to the repair of iron sulfur proteins and the in vivo expression of their cognate genes will be measured to gain insight into their role during ..
  49. Role of WhiB3 in M. tuberculosis virulence
    ADRIE STEYN; Fiscal Year: 2009
    ..the mechanism of this physiological event, we will identify the WhiB3 amino acids necessary for effective iron-sulfur (Fe-S) reconstitution, and use electron paramagnetic resonance spectroscopy (EPR) to characterize these mutated ..
  50. Antibiotic pressure and selection of TCA cycle mutants in Staphylococcus epidermi
    Paul D Fey; Fiscal Year: 2010
    ..Superoxide damages iron-sulfur clusters;the released ferrous ion is thus available for the Fenton reaction generating hydroxyl radicals...
  51. Crystallographic Studies of Electron Tranfer Proteins
    DOUGLAS CHARLES REES; Fiscal Year: 2012
    ..Nitrogenase is a prototypic example of an enzyme with multiple and varied iron-sulfur clusters that participate in electron transfer and substrate reduction, as well as providing an excellent model ..
  52. MOLECULAR REMEDY OF MITOCHONDRIAL DEFECTS
    Takao Yagi; Fiscal Year: 2013
    ..subunits (of these, 7 subunits are mitochondrially encoded (designated ND1-6 and 4L)), one FMN and eight iron- sulfur clusters as cofactors. Complex I defects are involved in many human mitochondrial diseases...
  53. NMR SPECTROSCOPY OF IRON-SULFUR PROTEINS
    John L Markley; Fiscal Year: 2010
    Iron-sulfur proteins are ubiquitous in nature and essential to life. Members of this class of metalloprotein play critical roles in biochemical processes ranging from respiration and detoxification to gene regulation and chemical sensing...
  54. Recruitment of a Bioinorganic Chemistry Faculty Member
    Michael K Johnson; Fiscal Year: 2010
    ..cofactors in fundamental life processes such as respiration, photosynthesis, and carbon, hydrogen, nitrogen and sulfur metabolism and the number and diversity of metalloproteins and the biological roles for metal centers continue to ..
  55. Novel Thioderivatives as Neuroprotective Anticonvulsants
    DOUGLAS ERIC BRENNEMAN; Fiscal Year: 2010
    ..The proposed compounds will contain one or more of the following domains: sulfamide or a sulfur-containing heterocycle...
  56. Natural engineering of multi-electron biological oxidation &reduction
    PETER LESLIE DUTTON; Fiscal Year: 2013
    ..Many key members align cofactors such as chlorins, hemes, iron-sulfur clusters, flavins, quinones and metals to form single-electron-transfer chains through protein over multi-..
  57. Structural Insights into the Function of Frataxin
    TIMOTHY LOUIS STEMMLER; Fiscal Year: 2013
    ..the functional role proteins play in regulating cellular iron homeostasis, with special interest regarding iron-sulfur cluster (ISC) bioassembly...
  58. Role of Hypoxia-Induced miR-210 in Tumor Metabolism
    Mircea Ivan; Fiscal Year: 2013
    ..in normoxia and hypoxia identified targets with functions in the mitochondrial electron transport: ISCU (Iron Sulfur Cluster Scaffold Homolog), SDHD (succinate dehydrogenase subunit D) and NDUFA4 (subunit of the NADH-ubiquinone ..
  59. Novel Therapeutic Approaches to Pathogen Inactivation
    James A Cowan; Fiscal Year: 2010
    ..include identification of inhibitor peptides that block the function of the essential protein IscU in iron-sulfur cluster biosynthesis. Such peptides will be lead candidates for drug development...
  60. ELEXSYS E500 CW EPR SPECTROMETER
    Jack H Freed; Fiscal Year: 2010
    ..structural and biochemical evidence that the first step of diphthamide biosynthesis in archaea uses a novel iron-sulfur cluster enzyme, DPH2...
  61. REGULATION OF IRON METABOLISM GENES IN EUKARYOTES
    William E Walden; Fiscal Year: 2010
    ..Organisms utilize iron in a variety of chemical forms, including as elemental iron, heme, and combined with sulfur in iron-sulfur (FeS) clusters...
  62. Structural Contexts and Functional Consequences of Protein S-nitrosylation
    Eric R Schreiter; Fiscal Year: 2010
    Protein S-nitrosylation, or the attachment of an NO group to the sulfur of a cysteine side chain (SNO) within a protein, is now recognized as an important mechanism for the post-translational regulation of protein function...
  63. REACTION MECHANISM OF MYOCARDIAC UBIQUINONE-PROTEINS
    Chang An Yu; Fiscal Year: 2009
    ..QCR is a functional dimer and that the catalytic cycle of the complex involves movement of the head domain of iron-sulfur protein (ISP)...
  64. MITOCHONDRIAL IRON-SULFUR PROTEINS
    Michael Johnson; Fiscal Year: 1991
    ..Iron- sulfur clusters are ubiquitous in mitochondrial electron transport and intimate knowledge of their type and function is a ..
  65. SULFUR OXIDES EFFECTS ON LUNG FUNCTION IN ASTHMATICS
    Jane Koenig; Fiscal Year: 1991
    ..The investigation of the pulmonary effects of sulfur oxide pollutants also will be extended to other age groups...
  66. NITROGEN OXIDE (NOX) REDOX CHEMISTRY WITH COPPER ION
    KENNETH KARLIN; Fiscal Year: 1993
    Chemical transformations involving the oxides of nitrogen (NOx) and sulfur (SOx) are of considerable environmental and biological importance. Industrial and other combustion (e.g...
  67. Fluorescence Imaging for Sentinel Lymph Node Mapping
    Eva Sevick Muraca; Fiscal Year: 2003
    ..of the sentinel or "closest" lymph node to the primary tumor involves nuclear imaging with technetium 99m sulfur colloid and enables minimal surgery and subsequent biopsy...
  68. ANIMAL MODEL OF DRUG-INDUCED SLE
    David Aucoin; Fiscal Year: 1990
    ..The induction of this disease is dose-dependent and requires a free sulfur group on PTU...
  69. STRUCTURAL STUDIES ON EUKARYOTIC MOCO CONTAINING ENZYMES
    Caroline Kisker; Fiscal Year: 2003
    Enzymes containing the molybdenum cofactor catalyze important reactions in the global sulfur, nitrogen and carbon cycles and are currently classified into four different families...
  70. ELECTRONIC STRUCTURE OF IRON-SULFUR AND RELATED PROTEINS
    Louis Noodleman; Fiscal Year: 2010
    A wide variety of iron-sulfur clusters and mixed-metal species are active sites in metalloenzymes...