fullerenes

Summary

Summary: A polyhedral CARBON structure composed of around 60-80 carbon atoms in pentagon and hexagon configuration. They are named after Buckminster Fuller because of structural resemblance to geodesic domes. Fullerenes can be made in high temperature such as arc discharge in an inert atmosphere.

Top Publications

  1. ncbi Carbon fullerenes (C60s) can induce inflammatory responses in the lung of mice
    Eun Jung Park
    College of Pharmacy, Dongduk Women s University, 23 1, Wolgok dong, Seongbuk gu, Seoul 136 714, Korea
    Toxicol Appl Pharmacol 244:226-33. 2010
  2. ncbi Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease
    Xiaoqing Cai
    Laboratory of Nanobiology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    J Neurosci Res 86:3622-34. 2008
  3. ncbi Modeled environmental concentrations of engineered nanomaterials (TiO(2), ZnO, Ag, CNT, Fullerenes) for different regions
    Fadri Gottschalk
    Empa, Swiss Federal Laboratories for Materials Testing and Research, Technology and Society Laboratory, CH 9014 St Gallen, Switzerland
    Environ Sci Technol 43:9216-22. 2009
  4. pmc Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells
    Alexey V Tkach
    Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Small 9:1686-90. 2013
  5. ncbi Fullerene C₆₀ as a multifunctional system for drug and gene delivery
    Alejandro Montellano
    Center of Excellence for Nanostructured Materials CENMAT, Department of Chemical and Pharmaceutical Sciences, and INSTM, Unit of Trieste University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy
    Nanoscale 3:4035-41. 2011
  6. pmc Innovative cationic fullerenes as broad-spectrum light-activated antimicrobials
    Liyi Huang
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114 2696, USA
    Nanomedicine 6:442-52. 2010
  7. ncbi Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes
    Liang Yan
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences CAS, National Center for Nanosciences and Technology of China, Beijing, 100049, China
    Nanoscale 3:362-82. 2011
  8. ncbi Cytotoxicity of water-soluble fullerene in vascular endothelial cells
    Hideyuki Yamawaki
    Dept of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Am J Physiol Cell Physiol 290:C1495-502. 2006
  9. pmc Simulation of nanoparticle permeation through a lipid membrane
    Steven L Fiedler
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    Biophys J 99:144-52. 2010
  10. ncbi Effect of fullerenol C(60)(OH) (24) on lipid peroxidation of kidneys, testes and lungs in rats treated with doxorubicine
    Ivana Vapa
    Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Republic of Serbia
    Eur J Drug Metab Pharmacokinet 37:301-7. 2012

Detail Information

Publications312 found, 100 shown here

  1. ncbi Carbon fullerenes (C60s) can induce inflammatory responses in the lung of mice
    Eun Jung Park
    College of Pharmacy, Dongduk Women s University, 23 1, Wolgok dong, Seongbuk gu, Seoul 136 714, Korea
    Toxicol Appl Pharmacol 244:226-33. 2010
    b>Fullerenes (C60s) occur in the environment due to natural and anthropogenic sources such as volcanic eruptions, forest fires, and the combustion of carbon-based materials...
  2. ncbi Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease
    Xiaoqing Cai
    Laboratory of Nanobiology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    J Neurosci Res 86:3622-34. 2008
    ..These data suggest that C(60)(OH)(24) is a mitochondrial protective antioxidant with direct radical scavenging activity and indirect antioxidant inducing activity...
  3. ncbi Modeled environmental concentrations of engineered nanomaterials (TiO(2), ZnO, Ag, CNT, Fullerenes) for different regions
    Fadri Gottschalk
    Empa, Swiss Federal Laboratories for Materials Testing and Research, Technology and Society Laboratory, CH 9014 St Gallen, Switzerland
    Environ Sci Technol 43:9216-22. 2009
    ..We modeled nano-TiO(2), nano-ZnO, nano-Ag, carbon nanotubes (CNT), and fullerenes for the U.S., Europe and Switzerland...
  4. pmc Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells
    Alexey V Tkach
    Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Small 9:1686-90. 2013
    Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells...
  5. ncbi Fullerene C₆₀ as a multifunctional system for drug and gene delivery
    Alejandro Montellano
    Center of Excellence for Nanostructured Materials CENMAT, Department of Chemical and Pharmaceutical Sciences, and INSTM, Unit of Trieste University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy
    Nanoscale 3:4035-41. 2011
    ..Several biomedical uses have been explored using water-soluble C(60)-derivatives. However, the employment of fullerenes for drug delivery is still at an early stage of development...
  6. pmc Innovative cationic fullerenes as broad-spectrum light-activated antimicrobials
    Liyi Huang
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114 2696, USA
    Nanomedicine 6:442-52. 2010
    ..are more water-soluble and can mediate photodynamic therapy efficiently upon illumination; moreover, cationic fullerenes can selectively bind to microbial cells...
  7. ncbi Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes
    Liang Yan
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences CAS, National Center for Nanosciences and Technology of China, Beijing, 100049, China
    Nanoscale 3:362-82. 2011
    ..to improve biocompatibility, regulate ADME, and reduce the toxicity of carbon nanomaterials (carbon nanotubes, fullerenes, metallofullerenes, and graphenes)...
  8. ncbi Cytotoxicity of water-soluble fullerene in vascular endothelial cells
    Hideyuki Yamawaki
    Dept of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Am J Physiol Cell Physiol 290:C1495-502. 2006
    ..In the present study, we have examined, for the first time, the toxicity of water-soluble fullerenes to ECs...
  9. pmc Simulation of nanoparticle permeation through a lipid membrane
    Steven L Fiedler
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    Biophys J 99:144-52. 2010
    ..The use of C(60) to represent similarly sized carbonaceous nanoparticles for assessments of toxicity is questioned...
  10. ncbi Effect of fullerenol C(60)(OH) (24) on lipid peroxidation of kidneys, testes and lungs in rats treated with doxorubicine
    Ivana Vapa
    Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Republic of Serbia
    Eur J Drug Metab Pharmacokinet 37:301-7. 2012
    ..A dose of 100 mg/kg i.p. exhibited a better protective effect. When fullerenol was applied alone, at a dose of 100 mg/kg i.p, it did not significantly affect the intensity of lipid peroxidation in all tested organs...
  11. ncbi Fullerene inhibits beta-amyloid peptide aggregation
    Jeong Eun Kim
    Fluorescence Nanoscopy Laboratory, Department of Chemistry, Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, South Korea
    Biochem Biophys Res Commun 303:576-9. 2003
    ..This work shows that fullerene can be a promising candidate in search of AD therapeutics because it has the very high IC(50) value for A beta aggregation...
  12. ncbi Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1 Hyakunin cho, Shinjuku ku, Tokyo, Japan
    Arch Toxicol 85:1429-40. 2011
    The cytotoxic effects of hydroxylated fullerenes, also termed fullerenols or fullerols [C(60)(OH)( n )], which are known nanomaterials and water-soluble fullerene derivatives, were ..
  13. ncbi Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cell
    Hongjian Liu
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Virginia School of Medicine, Hospital Drive, Charlottesville, Virginia, USA
    J Orthop Res 30:1051-7. 2012
    ..The results indicated that fullerol can potentially be used for prevention and treatment of corticosteroid-induced osteonecrosis...
  14. pmc Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability
    Ying Ying Zha
    CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, Hefei, People s Republic of China
    Int J Nanomedicine 7:3099-109. 2012
    ..This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons...
  15. ncbi Performance of an organic photodiode as an optical detector and its application to fluorometric flow-immunoassay for IgA
    Mayo Miyake
    Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi ku, Fukuoka 819 0395, Japan
    Talanta 96:132-9. 2012
    ..The detection limits for resorufin and IgA were 5.0μM and 16ng/mL, respectively. The photosensitivity of the OPD remained relatively constant for a minimum of one year...
  16. ncbi Fullerenes for applications in biology and medicine
    P Anilkumar
    Department of Chemistry and Laboratory for Emerging Materials and Technology, Clemson University, Clemson, South Carolina 29634 0973, USA
    Curr Med Chem 18:2045-59. 2011
    b>Fullerenes as a unique class of carbon allotropes have been studied extensively for their distinctive material properties and potential technological applications, including those in biology and medicine...
  17. ncbi Modulating activity of fullerol C60(OH)22 on doxorubicin-induced cytotoxicity
    Gordana Bogdanovic
    Institute of Oncology Sremska Kamenica, Institutski put 4, 21204 Sremska Kamenica, Serbia and Montenegro
    Toxicol In Vitro 18:629-37. 2004
    ..5 microg/ml of fullerol. The obtained results suggest that antiproliferative effect of the fullerol and its protective effect on DOX-induced cytotoxicity might be mediated through hydroxyl-radical scavenger activity of C60(OH)22...
  18. ncbi Nitric oxide-scavenging activity of polyhydroxylated fullerenol, C60(OH)24
    Snezana M Mirkov
    Department of Medicine, The University of Chicago, 5841 South Maryland Ave MC 2115, Chicago, IL 60637, USA
    Nitric Oxide 11:201-7. 2004
    ....
  19. ncbi Fullerenol C60(OH)24 prevents doxorubicin-induced acute cardiotoxicity in rats
    Vukosava Milic Torres
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av da Republica, Estação Agronómica Nacional, 2780 157 Oeiras, Portugal
    Pharmacol Rep 62:707-18. 2010
    ..Our results suggest that fullerenol might be a potential cardioprotective agent in DOX-treated individuals...
  20. ncbi Computer simulation study of fullerene translocation through lipid membranes
    Jirasak Wong-Ekkabut
    Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
    Nat Nanotechnol 3:363-8. 2008
    ..However, the mechanisms by which fullerenes penetrate and disrupt cell membranes are still poorly understood...
  21. pmc Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis
    Alexandre S Basso
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1532-43. 2008
    ..Our data demonstrate the neuroprotective effect of treatment with a fullerene compound combined with a NMDA receptor antagonist, which may be useful in the treatment of progressive MS and other neurodegenerative diseases...
  22. ncbi Uptake and translocation mechanisms of cationic amino derivatives functionalized on pristine C60 by lipid membranes: a molecular dynamics simulation study
    Sebastian Kraszewski
    Laboratoire de Nanomédecine, Imagerie et Thérapeuthique, Universite de Franche Comte, Centre Hospitalier Universitaire de Besancon, 25000 Besancon, France
    ACS Nano 5:8571-8. 2011
    ..Finally, the fullerenes bearing too many cationic groups display mostly a hydrophilic character; thus, the lipophilic fullerene core is ..
  23. ncbi Review of fullerene toxicity and exposure--appraisal of a human health risk assessment, based on open literature
    Karin Aschberger
    Nanobiosciences Unit, European Commission, DG Joint Research Centre JRC, Institute for Health and Consumer Protection IHCP, Via E Fermi, 2749, I 21027 Ispra, Italy
    Regul Toxicol Pharmacol 58:455-73. 2010
    b>Fullerenes have gained considerable attention due to their anti-oxidant and radical scavenging properties. Their current applications include targeted drug delivery, energy application, polymer modifications and cosmetic products...
  24. ncbi Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives
    Tadahiko Mashino
    Kyoritsu University of Pharmacy, Shibakoen 1 5 30, Minato ku, Tokyo 105 8512, Japan
    Bioorg Med Chem Lett 15:1107-9. 2005
    ..Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition...
  25. ncbi The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity
    Helinor J Johnston
    Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Edinburgh EH10 5DT, UK
    Toxicol Sci 114:162-82. 2010
    ..provides a comprehensive critical review of the available literature purporting to assess the toxicity of carbon fullerenes. This is required as prior to the widespread utilization and production of fullerenes, it is necessary to ..
  26. ncbi Potent angiogenesis inhibition by the particulate form of fullerene derivatives
    Huan Meng
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    ACS Nano 4:2773-83. 2010
    ..We propose that using nanoscale "particulate" itself as a new form of medicine (particulate medicine) may be superior to the traditional "molecular" form of medicine (molecular medicine) in cancer treatment...
  27. pmc Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes
    Janne K Folkmann
    Institute of Public Health, Department of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 117:703-8. 2009
    C60 fullerenes and single-walled carbon nanotubes (SWCNT) are projected to be used in medicine and consumer products with potential human exposure...
  28. ncbi Integrated thin-film polymer/fullerene photodetectors for on-chip microfluidic chemiluminescence detection
    Xuhua Wang
    Experimental Solid State Physics Group, Blackett Laboratory, Imperial College London, UK
    Lab Chip 7:58-63. 2007
    ....
  29. ncbi Aqueous fullerene aggregates (nC60) generate minimal reactive oxygen species and are of low toxicity in fish: a revision of previous reports
    Theodore B Henry
    School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, Devon, United Kingdom
    Curr Opin Biotechnol 22:533-7. 2011
    This review aims to clarify inconsistencies in previous reports regarding the potential for aqueous aggregates of fullerenes (nC60) to generate reactive oxygen species (ROS) and cause toxicity in fish...
  30. ncbi Comparison of electrokinetic properties of colloidal fullerenes (n-C60) formed using two procedures
    Jonathan Brant
    Department of Civil and Environmental Engineering, Rice University, Mail Stop 317, Houston, Texas 77251 1892, USA
    Environ Sci Technol 39:6343-51. 2005
    ..in water without the aid of organic solvents, a pathway that may be important in determining the mobility of fullerenes in natural systems...
  31. ncbi Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C60)
    Zoran Markovic
    Vinca Institute of Nuclear Sciences, Laboratory for Atomic Physics, P O Box 522, 11000 Belgrade, Serbia
    Biomaterials 29:3561-73. 2008
    ..Therefore, the dual property of fullerenes to either quench or generate cell-damaging ROS could be potentially exploited for their development as ..
  32. ncbi Multihydroxylated [Gd@C82(OH)22]n nanoparticles: antineoplastic activity of high efficiency and low toxicity
    Chunying Chen
    Lab for Bio Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Nano Lett 5:2050-7. 2005
    ..05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity...
  33. ncbi Effect of preparation methods on toxicity of fullerene water suspensions to Japanese medaka embryos
    Ki Tae Kim
    Department of Environmental Science and Engineering, Gwangju Institute of Science and Technology GIST, 261 Cheom dan Gwagi ro, Buk Gu, Gwangju 500 712, Republic of Korea
    Sci Total Environ 408:5606-12. 2010
    ..To summarize, these findings clearly illustrated the need to consider the effect of preparation method on the physicochemical properties when assessing nC(60) toxicity...
  34. ncbi Highly hydroxylated fullerene localizes at the cytoskeleton and inhibits oxidative stress in adipocytes and a subcutaneous adipose-tissue equivalent
    Li Xiao
    Laboratory of Cell Death Control BioTechnology, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shobara, Hiroshima, Japan
    Free Radic Biol Med 51:1376-89. 2011
    ..In conclusion, HHF is able to inhibit oxidative stress in adipocytes and adipogenesis-related macrophage activation in adipose tissues through its antioxidation...
  35. ncbi Protective effect of C(60) -methionine derivate on lead-exposed human SH-SY5Y neuroblastoma cells
    Tian Chen
    School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    J Appl Toxicol 31:255-61. 2011
    ..These observations suggest that FMD may serve as a potential antioxidative and neuroprotective agent in the prevention of lead intoxication...
  36. ncbi Recent progresses in application of fullerenes in cosmetics
    Marko Lens
    King s College, St Thomas s Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Recent Pat Biotechnol 5:67-73. 2011
    ..Fullerene C(60) and its derivates have been subject of intensive research in the last few years. Fullerenes display a wide range of different biological activities...
  37. pmc Water-soluble fullerene (C60) inhibits the development of arthritis in the rat model of arthritis
    Kazuo Yudoh
    Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan
    Int J Nanomedicine 4:217-25. 2009
    ..These findings indicate that C60 is a potential therapeutic agent for inhibition of arthritis...
  38. ncbi A molecular dynamics simulation study of C60 fullerenes inside a dimyristoylphosphatidylcholine lipid bilayer
    Liwei Li
    Department of Materials Science and Engineering, University of Utah, Salt Lake City, Utah 84112, USA
    J Phys Chem B 111:4067-72. 2007
    We have carried out atomistic molecular dynamics simulations of C60 fullerenes inside a dimyristoylphosphatidylcholine lipid bilayer and an alkane melt...
  39. ncbi Conjugation of functionalized gadolinium metallofullerenes with IL-13 peptides for targeting and imaging glial tumors
    Helen L Fillmore
    Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA
    Nanomedicine (Lond) 6:449-58. 2011
    ....
  40. pmc In vivo gene delivery by cationic tetraamino fullerene
    Rui Maeda-Mamiya
    Department of Chemistry and Exploratory Research for Advanced Technology Japan Science and Technology Agency, University of Tokyo, 7 3 1 Hongo Bunkyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 107:5339-44. 2010
    Application of nanotechnology to medical biology has brought remarkable success. Water-soluble fullerenes are molecules with great potential for biological use because they can endow unique characteristics of amphipathic property and form ..
  41. ncbi Toxicity of an engineered nanoparticle (fullerene, C60) in two aquatic species, Daphnia and fathead minnow
    Shiqian Zhu
    Environmental Toxicology Research Program, National Center for Natural Products Research, Department of Pharmacology, School of Pharmacy, The University of Mississippi, 347 Faser, University, MS 38677 1848, USA
    Mar Environ Res 62:S5-9. 2006
    ..2004. Manufactured nanomaterials (fullerenes, c60) induce oxidative stress in brain of juvenile largemouth bass. Environ. Health Persp...
  42. ncbi Antioxidant properties of fullerenol C60(OH)24 in rat kidneys, testes, and lungs treated with doxorubicin
    Branislava Srdjenovic
    Medical Faculty, Department of Pharmacy, University of Novi Sad, Hajduk Veljkova 3, Novi Sad, Serbia
    Toxicol Mech Methods 20:298-305. 2010
    ..Results of this study support the hypothesis of testicular, pulmo-, and nephroprotective efficacy of fullerenol in preventing oxidative stress induced by doxorubicin...
  43. ncbi Antibacterial activity of fullerene water suspensions: effects of preparation method and particle size
    Delina Y Lyon
    Department of Civil and Environmental Engineering and Department of Chemistry, Rice University, Houston, Texas 77005, USA
    Environ Sci Technol 40:4360-6. 2006
    ..This suggests the need for improved understanding of the behavior of FWS towards organisms and in the environment to determine how C60 can be safely used and disposed...
  44. ncbi Carboxyfullerenes localize within mitochondria and prevent the UVB-induced intrinsic apoptotic pathway
    Filomena Chirico
    Institute of Dermatology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Exp Dermatol 16:429-36. 2007
    ..Taken together, these results indicate that CF penetrate human keratinocytes, localize within mitochondria where they act both by scavenging free radicals and by protecting cells from apoptosis...
  45. pmc Cationic fullerenes are effective and selective antimicrobial photosensitizers
    George P Tegos
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, USA
    Chem Biol 12:1127-35. 2005
    b>Fullerenes are soccer ball-shaped molecules composed of carbon atoms, and, when derivatized with functional groups, they become soluble and can act as photosensitizers...
  46. pmc Effect of buckminsterfullerenes on cells of the innate and adaptive immune system: an in vitro study with human peripheral blood mononuclear cells
    Hanno Bunz
    Department of Internal Medicine II, University of Tubingen, Germany
    Int J Nanomedicine 7:4571-80. 2012
    ..Both fullerenes did not influence T cell reactivity, with no enhanced expression of CD69 and production of T cell cytokines ..
  47. ncbi A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties
    Sameh S Ali
    Center for the Study of Nervous System Injury CSNSI, Department of Neurology, Washington University, St Louis, MO 63130, USA
    Free Radic Biol Med 37:1191-202. 2004
    ..These data, coupled with evidence that C3 localizes to mitochondria, suggest that C3 functionally replaces MnSOD, acting as a biologically effective SOD mimetic...
  48. pmc Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of nanomedicine
    Seung gu Kang
    Computational Biology Center, IBM Thomas J Watson Research Center, Yorktown Heights, NY 10598, USA
    Proc Natl Acad Sci U S A 109:15431-6. 2012
    ..Our findings provide insights for de novo design of nanomedicines for fatal diseases such as pancreatic cancer...
  49. ncbi The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene
    Tarek Baati
    UMR CNRS 8612, Universite Paris Sud XI, Rue J B Clément F92296, Chatenay Malabry, France
    Biomaterials 33:4936-46. 2012
    ..These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C(60) including cancer therapy, neurodegenerative disorders, and ageing...
  50. pmc Non-destructive inhibition of metallofullerenol Gd@C(82)(OH)(22) on WW domain: implication on signal transduction pathway
    Seung gu Kang
    Computational Biology Center, IBM Thomas J Watson Research Center Yorktown Heights, NY 10598, USA
    Sci Rep 2:957. 2012
    ..Further analyses with binding free energy landscapes reveal that Gd@C(82)(OH)(22) can not only directly block the binding site of the WW domain, but also effectively distract the PRM from its native binding pocket...
  51. ncbi Characterization of surface hydrophobicity of engineered nanoparticles
    Yao Xiao
    Department of Civil and Environmental Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA
    J Hazard Mater 215:146-51. 2012
    ..Fullerol was shown to be the least hydrophobic of seven NPs tested. The advantages and limitations of each method were also discussed...
  52. ncbi Modification of antioxidative and antiapoptotic genes expression in irradiated K562 cells upon fullerenol C60(OH)24 nanoparticle treatment
    Karmen Stankov
    Medical Faculty Novi Sad, Clinical Center of Vojvodina, University of Novi Sad, Hajduk Veljkova 1, 21000 Novi Sad, Serbia
    J Nanosci Nanotechnol 13:105-13. 2013
    ....
  53. ncbi Toxicity of pristine versus functionalized fullerenes: mechanisms of cell damage and the role of oxidative stress
    Andreja Trpkovic
    Vinca Institute of Nuclear Sciences, University of Belgrade, POB 522, Belgrade, 11000, Serbia
    Arch Toxicol 86:1809-27. 2012
    ..Moreover, the widespread industrial utilization of fullerenes may also have implications for human health...
  54. pmc Changes in chemiluminescence of whole blood of COPD patients treated with Hypoxen and effects of C₆₀ fullerenes on blood chemiluminescence
    Kirill N Novikov
    Faculty of Biology, M V Lomonosov Moscow State University, Moscow, Russia
    Med Sci Monit 18:BR76-83. 2012
    ..The aim of this study was to evaluate the effect of Hypoxen treatment and the effect of HyFnC₆₀ on ROS production in patients' blood...
  55. ncbi Synthesis and characterization of a lithium-doped fullerane (Li(x)-C60-H(y)) for reversible hydrogen storage
    Joseph A Teprovich
    Clean Energy Directorate, Savannah River National Lab, P O Box A, Aiken, South Carolina 29808, USA
    Nano Lett 12:582-9. 2012
    ..an onset temperature of ~270 °C, which is significantly less than the desorption temperature of hydrogenated fullerenes (C(60)H(x)) and pure lithium hydride (decomposition temperature 500-600 and 670 °C respectively)...
  56. pmc Epoxyeicosatrienoic acids are involved in the C(70) fullerene derivative-induced control of allergic asthma
    Sarah K Norton
    Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA
    J Allergy Clin Immunol 130:761-769.e2. 2012
    b>Fullerenes are molecules being investigated for a wide range of therapeutic applications...
  57. pmc In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells
    J G Saathoff
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27607, USA
    Toxicol In Vitro 25:2105-12. 2011
    Carbon fullerenes possess unique properties and their interactions with biomolecules have widespread applications...
  58. ncbi Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules
    Xiaohui Yin
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences CAS, Beijing 100049, China
    Nanoscale 5:7341-8. 2013
    ..Compared to C60(OH)24, the interaction of Gd@C82(OH)22 with collagen is stronger, resulting in particular biomedical effects for regulating the biophysical properties of collagen fibrils. ..
  59. ncbi Uraninite and fullerene in atmospheric particulates
    Satoshi Utsunomiya
    Department of Nuclear Engineering and Radiological Sciences, Geological Sciences, University of Michigan, Ann Arbor, Michigan 48109 2104, USA
    Environ Sci Technol 36:4943-7. 2002
    ..We have also identified, for the first time, closely associated fullerenes, C60...
  60. ncbi Computational design of novel fullerene analogues as potential HIV-1 PR inhibitors: Analysis of the binding interactions between fullerene inhibitors and HIV-1 PR residues using 3D QSAR, molecular docking and molecular dynamics simulations
    Serdar Durdagi
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, 11635 Athens, Greece
    Bioorg Med Chem 16:9957-74. 2008
    ..Such structures may trigger the interest of medicinal chemists for novel HIV-1 PR inhibitors possessing higher bioactivity...
  61. ncbi In vitro and in vivo imaging studies of a new endohedral metallofullerene nanoparticle
    Panos P Fatouros
    Department of Radiology, Virginia Commonwealth University, Sanger Hall, B3 021, 1101 E Marshall St, PO Box 980072, Richmond, VA 23298 0072, USA
    Radiology 240:756-64. 2006
    ....
  62. ncbi The effect of fullerenes and functionalized fullerenes on Daphnia magna phototaxis and swimming behavior
    Kathryn A Brausch
    The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas, USA
    Environ Toxicol Chem 30:878-84. 2011
    The effects of carbon fullerenes (C(60) ) on the environment is a growing concern as the use of nanotechnology continues to increase...
  63. pmc Facile preparation of a new gadofullerene-based magnetic resonance imaging contrast agent with high 1H relaxivity
    Chunying Shu
    Chemistry Department, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Bioconjug Chem 20:1186-93. 2009
    ..The reactive carboxyl functionality present on this highly efficient contrast agent may also serve as a precursor for biomarker tissue-targeting purposes...
  64. ncbi Detection of a family of gadolinium-containing endohedral fullerenes and the isolation and crystallographic characterization of one member as a metal-carbide encapsulated inside a large fullerene cage
    Hua Yang
    Zhejiang California International Nanosystems Institute, Department of Chemistry, Zhejiang University, Hangzhou 310027, China
    J Am Chem Soc 130:17296-300. 2008
    ..Endohedral fullerenes of the type M(2)C(2n) can exist as the conventional endohedral, M(2)@C(2n), or as the carbide-containing ..
  65. ncbi Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice
    Jiangxue Wang
    Lab for Bio Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, P O Box 918, Beijing 100049, PR China
    Biochem Pharmacol 71:872-81. 2006
    ..The results suggest that [Gd@C82(OH)22]n nanoparticle treatment could regulate ROS production in vivo...
  66. ncbi Fullerene antioxidants decrease organophosphate-induced acetylcholinesterase inhibition in vitro
    Marion Ehrich
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
    Toxicol In Vitro 25:301-7. 2011
    ..b>Fullerenes are carbon spheres with antioxidant activity...
  67. ncbi Distinct cytotoxic mechanisms of pristine versus hydroxylated fullerene
    Aleksandra Isakovic
    Institute of Biochemistry, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia and Montenegro
    Toxicol Sci 91:173-83. 2006
    ....
  68. ncbi Baiting proteins with C60
    Matteo Calvaresi
    Dipartimento di Chimica G Ciamician, Universita di Bologna, V F Selmi 2, 40126 Bologna, Italy
    ACS Nano 4:2283-99. 2010
    ..A closer exam of the 10 top scorers is discussed in detail. New proteins that can interact with C60 are identified and discussed for possible future applications as drug targets and fullerene derivatives bioconjugate materials...
  69. ncbi Optical heating and rapid transformation of functionalized fullerenes
    Vijay Krishna
    Particle Engineering Research Center, University of Florida, Gainesville, FL 32611, USA
    Nat Nanotechnol 5:330-4. 2010
    ..Here, we show that certain functionalized fullerenes, including polyhydroxy fullerenes (which are known to be environmentally safe and to have therapeutic properties)..
  70. pmc C60 binds to and deforms nucleotides
    Xiongce Zhao
    Nanomaterials Theory Institute, Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
    Biophys J 89:3856-62. 2005
    ..Despite the hydrophobic nature of C60, our results show that fullerenes strongly bind to nucleotides...
  71. ncbi A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice
    Kevin L Quick
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, United States
    Neurobiol Aging 29:117-28. 2008
    ..SOD mimetics with such characteristics may provide unique complements to genetic strategies to study the contribution of oxidative processes to nervous system aging...
  72. pmc Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction
    Denise N Johnson-Lyles
    Nanotechnology Characterization Lab NCL, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Toxicol Appl Pharmacol 248:249-58. 2010
    Water soluble fullerenes, such as the hydroxylated fullerene, fullerenol (C₆₀OHx), are currently under development for diagnostic and therapeutic biomedical applications in the field of nanotechnology...
  73. pmc Phototoxicity and cytotoxicity of fullerol in human lens epithelial cells
    Joan E Roberts
    Department of Natural Sciences, Fordham University, 113 West 60th Street, New York City, NY 10023, USA
    Toxicol Appl Pharmacol 228:49-58. 2008
    ..Before fullerols are used to deliver drugs to the eye, they should be tested for photo- and cytotoxicity in vivo...
  74. ncbi Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles
    Sarah B Lovern
    University of Wisconsin Milwaukee, Great Lakes WATER Institute, 600 E Greenfield Avenue, Milwaukee, Wisconsin 53204, USA
    Environ Toxicol Chem 25:1132-7. 2006
    ..to filtered C60 and filtered TiO2 caused an increase in mortality with an increase in concentration, whereas fullerenes show higher levels of toxicity at lower concentrations...
  75. ncbi Toxicity studies of fullerenes and derivatives
    Jelena Kolosnjaj
    UMR CNRS 8612, Faculte de Pharmacie, Universite Paris Sud 11, Chatenay Malabry, France
    Adv Exp Med Biol 620:168-80. 2007
    Due to their unique properties, fullerenes, a model of carbon-based nanoparticles, have attracted considerable interest in many fields of research including material science and biomedical applications...
  76. ncbi Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene
    Guang Jia
    Department of Occupational and Environmental Health, School of Public Health, Peking University, Beijing 100083, China
    Environ Sci Technol 39:1378-83. 2005
    ..Carbon nanomaterials with different geometric structures exhibit quite different cytotoxicity and bioactivity in vitro, although they may not be accurately reflected in the comparative toxicity in vivo...
  77. ncbi Nano-C60 cytotoxicity is due to lipid peroxidation
    Christie M Sayes
    Department of Chemistry, 6100 Main St MS 60, Rice University, Houston, TX 77005, USA
    Biomaterials 26:7587-95. 2005
    ..With the addition of an antioxidant, L-ascorbic acid, the oxidative damage and resultant toxicity of nano-C60 was completely prevented...
  78. pmc Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass
    Eva Oberdörster
    Duke University Marine Laboratory, Beaufort, North Carolina, USA
    Environ Health Perspect 112:1058-62. 2004
    ..It is likely that nanomaterials can affect wildlife if they are accidentally released into the environment. The fullerenes are one type of manufactured nanoparticle that is being produced by tons each year, and initially uncoated ..
  79. pmc High relaxivity trimetallic nitride (Gd3N) metallofullerene MRI contrast agents with optimized functionality
    Jianfei Zhang
    Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, USA
    Bioconjug Chem 21:610-5. 2010
    ....
  80. ncbi Visualizing the uptake of C60 to the cytoplasm and nucleus of human monocyte-derived macrophage cells using energy-filtered transmission electron microscopy and electron tomography
    Alexandra E Porter
    The Nanoscience Centre, University of Cambridge, 11 JJ Thompson Avenue, Cambridge CB3 OFF, UK
    Environ Sci Technol 41:3012-7. 2007
    ..We confirm that C60 is taken up by HMMs in vitro and is sequestered at several sites within the cell. These sites include the cytoplasm, lysosomes, and most significantly the cell nuclei...
  81. ncbi Sonodynamically-induced anticancer effects by functionalized fullerenes
    Nagahiko Yumita
    Yokohama College of Pharmacy, 601, Matano cho, Totsuka ku, Yokohama, Kanagawa 245 0066, Japan
    Anticancer Res 33:3145-51. 2013
    Functionalized fullerenes, such as polyhydroxy fullerenes (PHF), have attracted particular attention due to their water solubility and their potential application in tumor imaging and therapy as carbon nanomaterials...
  82. ncbi Photo-induced reactive oxygen species generation by different water-soluble fullerenes (C) and their cytotoxicity in human keratinocytes
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 84:1215-23. 2008
    ..In vitro tests with HaCaT keratinocytes provided evidence that (gamma-CyD)(2)/C(60) phototoxicity is mainly mediated by (1)O(2) (Type II mechanism) with only a minor contribution from free radicals (Type I mechanism)...
  83. pmc Fullerene nanomaterials inhibit phorbol myristate acetate-induced inflammation
    Anthony Dellinger
    Luna nanoWorks, Danville, VA, USA
    Exp Dermatol 18:1079-81. 2009
    ..Oxidative stress, the generation of reactive oxygen species, is thought to be one component of this response. Fullerenes can counteract reactive oxygen species due to their potent antioxidant capabilities...
  84. ncbi Fullerenes: from carbon to nanomedicine
    Pooja Chawla
    Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Lucknow 227105, India
    Mini Rev Med Chem 10:662-77. 2010
    b>Fullerenes, the third carbon allotrope, have emerged as agents which could revolutionize the treatment of many diseases...
  85. ncbi Passive transport of C60 fullerenes through a lipid membrane: a molecular dynamics simulation study
    Dmitry Bedrov
    Department of Materials Science and Engineering, 122 South Central Campus Drive Room 304, University of Utah, Salt Lake City, Utah 84112, USA
    J Phys Chem B 112:2078-84. 2008
    To investigate the implications of the unique properties of fullerenes on their interaction with and passive transport into lipid membranes, atomistic molecular dynamics simulations of a C60 fullerene in a fully hydrated di-myristoyl-..
  86. ncbi Structural analysis of lead fullerene-based inhibitor bound to human immunodeficiency virus type 1 protease in solution from molecular dynamics simulations
    Vannajan S Lee
    Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
    J Mol Graph Model 26:558-70. 2007
    ..The simulated results lead to the conclusion that the active site of the HIVP complexed with the diphenyl C60 alcohol is the diprotonation states on Asp25 and Asp25'...
  87. ncbi Use of fullerenes in cosmetics
    Marko Lens
    King s College, Genetic Epidemiology Unit, St Thomas s Hospital, Lambeth Palace Road, London, UK
    Recent Pat Biotechnol 3:118-23. 2009
    ..b>Fullerenes display a wide range of biological activities...
  88. ncbi Theoretical study on the ground state structure of uranofullerene U@C82
    Xin Liu
    School of Chemistry, Dalian University of Technology, Dalian 116024, China
    J Phys Chem A 116:11651-5. 2012
    ..The proposed geometry and electronic structure of U(3+)@(#9)C(82)(3-) are in good agreement with the experimental observation...
  89. ncbi Fullerene nanomaterials inhibit the allergic response
    John J Ryan
    Department of Biology, Virginia Commonwealth University Health Systems, Richmond, VA 23294, USA
    J Immunol 179:665-72. 2007
    b>Fullerenes are a class of novel carbon allotropes that may have practical applications in biotechnology and medicine...
  90. ncbi Structural and electronic properties of new fullerene derivatives and their possible application as HIV-1 protease inhibitors
    Medhat Ibrahim
    Spectroscopy Department, National Research Centre, Dokki, Cairo, Egyp
    Spectrochim Acta A Mol Biomol Spectrosc 75:702-9. 2010
    ..Results show that some of the investigated fullerene-based derivatives can be considered promising as HIV-1 protease inhibitors...
  91. pmc Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex
    Mustafa Raoof
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
    Biomaterials 33:2952-60. 2012
    ....
  92. ncbi Gene expression of zebrafish embryos exposed to titanium dioxide nanoparticles and hydroxylated fullerenes
    Boris Jovanović
    The College of Veterinary Medicine, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA
    Ecotoxicol Environ Saf 74:1518-25. 2011
    ..in the otic vesicle with a sublethal dose of engineered nanoparticles (titanium dioxide/TiO(2) and hydroxylated fullerenes/C(60)(OH)(24))...
  93. pmc Liposomal formulation of amphiphilic fullerene antioxidants
    Zhiguo Zhou
    Luna nanoWorks, a division of Luna Innovations Incorporated, 521 Bridge Street, Danville, VA 24541, USA
    Bioconjug Chem 21:1656-61. 2010
    ..The antioxidant property of fullerenes is retained in the bipolarly functionalized C(70) derivative, amphiphilic liposomal malonylfullerene[70] (ALM), ..
  94. ncbi The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH--towards novel bacterial antiadhesives
    Maxime Durka
    University of Namur FUNDP, Departement de Chimie, Laboratoire de Chimie Bio Organique, Rue de Bruxelles 61, B 5000 Namur, Belgium
    Chem Commun (Camb) 47:1321-3. 2011
    ....
  95. ncbi Bioaccumulation of 14C60 by the earthworm Eisenia fetida
    Dong Li
    Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, United States
    Environ Sci Technol 44:9170-5. 2010
    Carbon fullerenes, including buckminsterfullerene (C(60)), are increasingly available for numerous applications, thus increasing the likelihood of environmental release...
  96. ncbi Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin
    Jillian G Rouse
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Sciences, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Nano Lett 7:155-60. 2007
    ..TEM analysis revealed fullerene-peptide localization within the intercellular spaces of the stratum granulosum...
  97. ncbi Biosafety assessment of Gd@C82(OH)22 nanoparticles on Caenorhabditis elegans
    Wendi Zhang
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Nanoscale 3:2636-41. 2011
    ..Our work lays the foundations for further developments of this anti-neoplastic agent for clinical applications...
  98. ncbi Curved pi-conjugation, aromaticity, and the related chemistry of small fullerenes (< C60) and single-walled carbon nanotubes
    Xin Lu
    State Key Laboratory of Physical Chemistry of Solid Surfaces and Center for Theoretical Chemistry, Department of Chemistry, Xiamen University, Xiamen 361005, China
    Chem Rev 105:3643-96. 2005
  99. ncbi Enhancement of titanium dioxide photocatalysis by water-soluble fullerenes
    Vijay Krishna
    Particle Engineering Research Center, 205 Particle Science and Technology Building, PO Box 116135, University of Florida, Gainesville, FL 32611, USA
    J Colloid Interface Sci 304:166-71. 2006
    b>Fullerenes are known for their unique electronic properties including high electron affinity...
  100. ncbi Comparative photoactivity and antibacterial properties of C60 fullerenes and titanium dioxide nanoparticles
    Lena Brunet
    Department of Civil and Environmental Engineering, Rice University, Houston, Texas, USA
    Environ Sci Technol 43:4355-60. 2009
    The production of reactive oxygen species (ROS) by aqueous suspensions of fullerenes and nano-TiO2 (Degussa P25) was measured both in ultrapure water and in minimal Davis (MD) microbial growth medium...
  101. ncbi Incomplete exciton harvesting from fullerenes in bulk heterojunction solar cells
    George F Burkhard
    Department of Applied Physics, Stanford University, Stanford, California 94305, USA
    Nano Lett 9:4037-41. 2009
    ..This result has implications for most state of the art organic solar cells, since all of the most efficient devices use fullerenes as electron acceptors.

Research Grants48

  1. Detection of engineered nanomaterials in drinking water, food, commercial product
    Paul K Westerhoff; Fiscal Year: 2010
    ..and mass concentration of the currently most widely used inorganic NMs (Ag, TiO2, Au) and carbonaceous NMs (fullerenes and functionalized fullerenes)...
  2. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2009
    ..Keywords lung burden, fibrosis, toxicity and carcinogenicity, metal working fluids, abrasive blasting agents, fullerenes, nanomaterials, artificial butter flavorings, antimony trioxide, ortho-phthalaldehyde
  3. Treatment of glucocorticoid-induced osteonecrosis with nano-fullerenes
    Quanjun Cui; Fiscal Year: 2013
    ..therapeutic approach toward glucocorticoid-induced osteonecrosis of the femoral head (ONFH), using nano-fullerenes which function as outstanding reactive oxygen species (ROS) scavengers...
  4. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALS
    Jacob McDonald; Fiscal Year: 2011
    ..fiscal year (2009), studies involving the fate (in vitro and/or in vivo) of cumene, dimethylethanolamine (DMAE), fullerenes, 2',2'''-dithiobisbenzanilide (DTBBA), and 2-hydroxy-4-methoxybenzophenone (HMB), have been ..
  5. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALS
    Jacob McDonald; Fiscal Year: 2009
    ..fiscal year (2009), studies involving the fate (in vitro and/or in vivo) of cumene, dimethylethanolamine (DMAE), fullerenes, 2[unreadable],2[unreadable][unreadable][unreadable]-dithiobisbenzanilide (DTBBA), and 2-hydroxy-4-..
  6. Interactions of engineered nanomaterials with lung alveolar epithelium
    EDWARD DAVID CRANDALL; Fiscal Year: 2010
    ..reports on health effects of inhaled ultrafine air pollutant particulates and other nanomaterials (especially fullerenes and their derivatives), we hypothesize that interactions between various forms of ENM (e.g., negative vs...
  7. Fullerenes Counteracting Organophosphorus Threats
    Marion F Ehrich; Fiscal Year: 2010
    ..Our preliminary data show water soluble hydroxylated C60 fullerenes (C60-OH) have ability to decrease AChE inhibition in neuronal cells...
  8. New Stereoregular Functionalized Fullerenes as Nanomedicines for PDT
    Long Y Chiang; Fiscal Year: 2012
    ..We have established some of the molecular structural features of fullerenes that mediate broad-spectrum photokilling of microbial cells and cancer cells...
  9. Nanoparticle Effects on Epithelial Cell Protein Expression and Function
    Frank A Witzmann; Fiscal Year: 2012
    DESCRIPTION (provided by applicant) Our hypothesis contends that manufactured carbon nanoparticles (fullerenes, single-walled nanotubes, and multi-walled nanotubes), when exposed to barrier epithelial (bronchiolar, intestinal, and kidney) ..
  10. Using Nanomaterials to Inhibit Mast Cell/Basophil-Associated Disease
    Chris L Kepley; Fiscal Year: 2012
    ..One form of nanomaterials, fullerenes, is soccer-ball-shaped carbon cages that can be functionalized and derivatized with a wide array of molecules...
  11. Prevention of Allergic Disease Using Nanomaterials
    Christopher L Kepley; Fiscal Year: 2010
    ..One form of nanomaterials, fullerenes, is soccer-ball-shaped carbon cages that can be functionalized and derivatized with a wide array of molecules...
  12. Treatment of disc degeneration by nano-fullerenes
    XUDONG JOSHUA LI; Fiscal Year: 2012
    ....
  13. Development of New Atomic-Based EPR Spin Probes
    John M Alford; Fiscal Year: 2012
    ..probes, we propose to investigate new types of spin probes based upon paramagnetic atoms encapsulated in C60 fullerenes that will have higher sensitivity in their ability to detect reactive oxygen species...
  14. Improved Spin Probes for Magnetic Resonance Imaging of Oxygen and Reactive Oxygen
    LAURA DUGAN; Fiscal Year: 2009
    ..probes, we propose to investigate spin probes based upon single paramagnetic nitrogen atoms encapsulated in C60 fullerenes, N@C60...
  15. Trimetallic Nitride Templated Endohedral Metallofullerenes as Dual Imaging and Mu
    MARISSA RYLANDER; Fiscal Year: 2009
    The project objective is to investigate a novel class of fullerenes called trimetallic nitride templated endohedral metallofullerenes (TNT EMFs) as dual imaging and multimodal therapeutic agents for laser cancer therapy...
  16. Photodynamic Therapy of Disseminated Peritoneal Tumor Using New Photosensitizers
    J Wharton; Fiscal Year: 2009
    ..One major advantage of our PS is that laser light is not needed. In addition, because fullerenes do not absorb red light, phototoxicity related to deep tissue penetrating light is minimized...
  17. INTRACELLULAR MOLECULAR ANALYSIS REQUIRED ENHANCED ION MOBILITY OTOFMS DATA ACQU
    J Albert Schultz; Fiscal Year: 2009
    ..for MALDI-IM-oTOFMS is proposed through the use of internal mass (and mobility) standards comprising giant fullerenes. Realtime calibration of Ion mobility drift times and m/z with ppm mass accuracy can be achieved using specially ..
  18. Free radicals detection in aging brain by fullerenes
    VLADIMIR DIDENKO; Fiscal Year: 2003
    ..b>Fullerenes were discovered by a Nobel laureate Richard Smalley in1985 and are physiologically inert...
  19. GADOLINIUM CONTAINING FULLERENES AS MRI CONTRAST AGENTS
    JOHN ALFORD; Fiscal Year: 2000
    Endohedral fullerenes containing Gd atoms are a promising new class of compounds with the potential to be superior MRI contrast agents...
  20. Development of Improved Spin Probes for Aging Research
    JOHN ALFORD; Fiscal Year: 2007
    ..we propose to investigate spin probes based upon single paramagnetic nitrogen atoms encapsulated in C60 fullerenes, N@C60...
  21. DEVELOPMENT OF CARBOXYFULLERENE DRUGS TO TREAT ALS
    JOHN ALFORD; Fiscal Year: 2003
    ..pharmaceuticals are one of the most unique, yet important and commercially viable applications of fullerenes to date...
  22. RESCUE FROM NIGROSTRIATAL INJURY
    Joel Perlmutter; Fiscal Year: 2003
    ..If this strategy works, these results will provide the preliminary data for a proper trial of these promising drugs in humans. ..
  23. Comparative In Vivo Biodistribution of Characterized Manufactured Nanomaterials
    Nancy A Monteiro Riviere; Fiscal Year: 2010
    ..the physicochemical interactions between MNM and biological systems by conducting in vivo ADME studies of fullerenes and single walled carbon nanotubes (SWNT) in rats and pigs, along with intensive physicochemical ..
  24. Improved Manufacturing Processes for Advanced Imaging Ag
    ROBERT BOLSKAR; Fiscal Year: 2005
    ..These can help improve MRI scans used for detecting diseases and are also potentially useful for other medical treatments and applications. ..
  25. Cut Nanotube Capsules for MR Imaging (RMI)
    ROBERT BOLSKAR; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  26. Fullerene Immunoconjugates for Cancer Imaging and Treatment
    ROBERT BOLSKAR; Fiscal Year: 2008
    ..b>Fullerenes are non-toxic carbon cage molecules with a rich derivatization chemistry useful for conjugating drug molecules, ..
  27. New MR Angiography Agents Using Gd@C60 Nanotechnology
    ROBERT BOLSKAR; Fiscal Year: 2004
    ..The new Gd-C60 compounds created in this study will fill a unique niche in angiographic MR imaging applications, for example the non-invasive detection of vascular abnormalities, while exceeding the safety levels of current Gd chelates. ..
  28. Superior Coatings for Semiconductor Quantum Dots
    ROBERT BOLSKAR; Fiscal Year: 2007
    ..Public health benefits resulting from this project will include safer, more potent means for diagnosis and treatment of disease, both in laboratory tests and for patients. [unreadable] [unreadable] [unreadable]..
  29. Improved Safe Alternative to Semiconductor Quantum Dots
    ROBERT BOLSKAR; Fiscal Year: 2005
    ..The platform for new QD agents created in this project will offer superior fluorophores for biological and medial imaging. ..
  30. Developing a CEST Reporter Gene (RMI)
    JEFF BULTE; Fiscal Year: 2008
    ..To achieve this goal, our aim is to synthesize novel, more efficient CEST reporter genes, and to detect double-labeled LRP/ARP transfected glioma cells and neural stem cells individually in live animals. [unreadable] [unreadable]..
  31. A Computational Docking Resource for Cancer Research
    Arthur Olson; Fiscal Year: 2006
    ..Formal training workshops will provide training on the most popular modeling and simulation methods to the wider NCI community. This Resource will both accelerate and extend research in Cancer Biology for the NCI community. ..
  32. Carbon Antioxidants to Prevent Diabetic Complications
    MICHAEL DIENER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. IRON PORPHYRIN ACTIVATION OF DIOXYGEN/SMALL MOLECULES
    ALAN BALCH; Fiscal Year: 2004
    ....
  34. Carbon Antioxidants To Prevent Atherosclerosis
    MICHAEL DIENER; Fiscal Year: 2003
    ..This project will study whether carbon-based antioxidants can extend their success to LDL protection and confer their benefits in vivo for retarding atherosclerosis. ..
  35. Metallofullerene Nanoplatform for Imaging & Treatment
    Panos Fatouros; Fiscal Year: 2009
    ..D. WILSON, PhD, radiobiologist and Director Animal Imaging, VCU Molecular Imaging Center;H. L. FILLMORE, PhD, molecular neurobiologist, expert in tumor targeting strategies. ..
  36. ASN Workshop "In Vivo MR Tracking of Stem Cells in the CNS" (R13)
    JEFF BULTE; Fiscal Year: 2005
    ..The outcome of the workshop will be published in Experimental Neurology and available for the scientific community at large. ..
  37. Molecular Cages for Alpha Particle Radioimmunotherapy
    MICHAEL DIENER; Fiscal Year: 2002
    ..The development of such a therapy has a potential market of approximately 300,000 Americans/yr. ..
  38. Radiopharmaceuticals for Tumor Imaging and Photodynamic Therapy
    Ravindra Pandey; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  39. MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet Cells
    JEFF BULTE; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  40. Development/Bifunctional MR Agents/Diagnosis and Therapy
    Ravindra Pandey; Fiscal Year: 2007
    ..abstract_text> ..
  41. Drug Design Cycle Targeting HIV Protease Drug Resistance
    Arthur Olson; Fiscal Year: 2007
    ..abstract_text> ..
  42. MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet Cells
    JEFF BULTE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. TANDEM TIME-OF-FLIGHT FOR PROTEOMICS ANALYSIS
    Robert Cotter; Fiscal Year: 2005
    ..This technology is expected to bring high performance and tandem capabilities to a simple, compact instrument that can be utilized in proteomics research. ..
  44. Metabolomics: Markers of Drug-Induced Liver Injury(RMI)
    Susan Sumner; Fiscal Year: 2008
    ..The signals defining these patterns will be identified using GC-MS, NMR, and LC-MS/MS methods and then assigned to biochemical pathways for defining the relevancy of the marker profiles to mode of action. ..
  45. Purchase of a Linear Ion Trap/Fourier Transform Mass Spectrometer
    Robert Cotter; Fiscal Year: 2007
    ..The instrument will be housed in and managed by the Middle Atlantic Mass Spectrometry Laboratory and operated by four individuals representing the Major Users and collaborators. [unreadable] [unreadable] [unreadable]..
  46. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2009
    ..abstract_text> ..