Genomes and Genes
Summary: A polyhedral CARBON structure composed of around 60-80 carbon atoms in pentagon and hexagon configuration. They are named after Buckminster Fuller because of structural resemblance to geodesic domes. Fullerenes can be made in high temperature such as arc discharge in an inert atmosphere.
Publications312 found, 100 shown here
- Carbon fullerenes (C60s) can induce inflammatory responses in the lung of miceEun Jung Park
College of Pharmacy, Dongduk Women s University, 23 1, Wolgok dong, Seongbuk gu, Seoul 136 714, Korea
Toxicol Appl Pharmacol 244:226-33. 2010b>Fullerenes (C60s) occur in the environment due to natural and anthropogenic sources such as volcanic eruptions, forest fires, and the combustion of carbon-based materials...
- Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's diseaseXiaoqing Cai
Laboratory of Nanobiology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
J Neurosci Res 86:3622-34. 2008..These data suggest that C(60)(OH)(24) is a mitochondrial protective antioxidant with direct radical scavenging activity and indirect antioxidant inducing activity...
- Modeled environmental concentrations of engineered nanomaterials (TiO(2), ZnO, Ag, CNT, Fullerenes) for different regionsFadri Gottschalk
Empa, Swiss Federal Laboratories for Materials Testing and Research, Technology and Society Laboratory, CH 9014 St Gallen, Switzerland
Environ Sci Technol 43:9216-22. 2009..We modeled nano-TiO(2), nano-ZnO, nano-Ag, carbon nanotubes (CNT), and fullerenes for the U.S., Europe and Switzerland...
- Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cellsAlexey V Tkach
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
Small 9:1686-90. 2013Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells...
- Fullerene C₆₀ as a multifunctional system for drug and gene deliveryAlejandro Montellano
Center of Excellence for Nanostructured Materials CENMAT, Department of Chemical and Pharmaceutical Sciences, and INSTM, Unit of Trieste University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy
Nanoscale 3:4035-41. 2011..Several biomedical uses have been explored using water-soluble C(60)-derivatives. However, the employment of fullerenes for drug delivery is still at an early stage of development...
- Innovative cationic fullerenes as broad-spectrum light-activated antimicrobialsLiyi Huang
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114 2696, USA
Nanomedicine 6:442-52. 2010..are more water-soluble and can mediate photodynamic therapy efficiently upon illumination; moreover, cationic fullerenes can selectively bind to microbial cells...
- Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenesLiang Yan
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences CAS, National Center for Nanosciences and Technology of China, Beijing, 100049, China
Nanoscale 3:362-82. 2011..to improve biocompatibility, regulate ADME, and reduce the toxicity of carbon nanomaterials (carbon nanotubes, fullerenes, metallofullerenes, and graphenes)...
- Cytotoxicity of water-soluble fullerene in vascular endothelial cellsHideyuki Yamawaki
Dept of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
Am J Physiol Cell Physiol 290:C1495-502. 2006..In the present study, we have examined, for the first time, the toxicity of water-soluble fullerenes to ECs...
- Simulation of nanoparticle permeation through a lipid membraneSteven L Fiedler
Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA
Biophys J 99:144-52. 2010..The use of C(60) to represent similarly sized carbonaceous nanoparticles for assessments of toxicity is questioned...
- Effect of fullerenol C(60)(OH) (24) on lipid peroxidation of kidneys, testes and lungs in rats treated with doxorubicineIvana Vapa
Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Republic of Serbia
Eur J Drug Metab Pharmacokinet 37:301-7. 2012..A dose of 100 mg/kg i.p. exhibited a better protective effect. When fullerenol was applied alone, at a dose of 100 mg/kg i.p, it did not significantly affect the intensity of lipid peroxidation in all tested organs...
- Fullerene inhibits beta-amyloid peptide aggregationJeong Eun Kim
Fluorescence Nanoscopy Laboratory, Department of Chemistry, Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, South Korea
Biochem Biophys Res Commun 303:576-9. 2003..This work shows that fullerene can be a promising candidate in search of AD therapeutics because it has the very high IC(50) value for A beta aggregation...
- Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunctionYoshio Nakagawa
Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1 Hyakunin cho, Shinjuku ku, Tokyo, Japan
Arch Toxicol 85:1429-40. 2011The cytotoxic effects of hydroxylated fullerenes, also termed fullerenols or fullerols [C(60)(OH)( n )], which are known nanomaterials and water-soluble fullerene derivatives, were ..
- Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cellHongjian Liu
Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Virginia School of Medicine, Hospital Drive, Charlottesville, Virginia, USA
J Orthop Res 30:1051-7. 2012..The results indicated that fullerol can potentially be used for prevention and treatment of corticosteroid-induced osteonecrosis...
- Concentration-dependent effects of fullerenol on cultured hippocampal neuron viabilityYing Ying Zha
CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, Hefei, People s Republic of China
Int J Nanomedicine 7:3099-109. 2012..This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons...
- Performance of an organic photodiode as an optical detector and its application to fluorometric flow-immunoassay for IgAMayo Miyake
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi ku, Fukuoka 819 0395, Japan
Talanta 96:132-9. 2012..The detection limits for resorufin and IgA were 5.0μM and 16ng/mL, respectively. The photosensitivity of the OPD remained relatively constant for a minimum of one year...
- Fullerenes for applications in biology and medicineP Anilkumar
Department of Chemistry and Laboratory for Emerging Materials and Technology, Clemson University, Clemson, South Carolina 29634 0973, USA
Curr Med Chem 18:2045-59. 2011b>Fullerenes as a unique class of carbon allotropes have been studied extensively for their distinctive material properties and potential technological applications, including those in biology and medicine...
- Modulating activity of fullerol C60(OH)22 on doxorubicin-induced cytotoxicityGordana Bogdanovic
Institute of Oncology Sremska Kamenica, Institutski put 4, 21204 Sremska Kamenica, Serbia and Montenegro
Toxicol In Vitro 18:629-37. 2004..5 microg/ml of fullerol. The obtained results suggest that antiproliferative effect of the fullerol and its protective effect on DOX-induced cytotoxicity might be mediated through hydroxyl-radical scavenger activity of C60(OH)22...
- Nitric oxide-scavenging activity of polyhydroxylated fullerenol, C60(OH)24Snezana M Mirkov
Department of Medicine, The University of Chicago, 5841 South Maryland Ave MC 2115, Chicago, IL 60637, USA
Nitric Oxide 11:201-7. 2004....
- Fullerenol C60(OH)24 prevents doxorubicin-induced acute cardiotoxicity in ratsVukosava Milic Torres
Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av da Republica, Estação Agronómica Nacional, 2780 157 Oeiras, Portugal
Pharmacol Rep 62:707-18. 2010..Our results suggest that fullerenol might be a potential cardioprotective agent in DOX-treated individuals...
- Computer simulation study of fullerene translocation through lipid membranesJirasak Wong-Ekkabut
Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
Nat Nanotechnol 3:363-8. 2008..However, the mechanisms by which fullerenes penetrate and disrupt cell membranes are still poorly understood...
- Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosisAlexandre S Basso
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 118:1532-43. 2008..Our data demonstrate the neuroprotective effect of treatment with a fullerene compound combined with a NMDA receptor antagonist, which may be useful in the treatment of progressive MS and other neurodegenerative diseases...
- Uptake and translocation mechanisms of cationic amino derivatives functionalized on pristine C60 by lipid membranes: a molecular dynamics simulation studySebastian Kraszewski
Laboratoire de Nanomédecine, Imagerie et Thérapeuthique, Universite de Franche Comte, Centre Hospitalier Universitaire de Besancon, 25000 Besancon, France
ACS Nano 5:8571-8. 2011..Finally, the fullerenes bearing too many cationic groups display mostly a hydrophilic character; thus, the lipophilic fullerene core is ..
- Review of fullerene toxicity and exposure--appraisal of a human health risk assessment, based on open literatureKarin Aschberger
Nanobiosciences Unit, European Commission, DG Joint Research Centre JRC, Institute for Health and Consumer Protection IHCP, Via E Fermi, 2749, I 21027 Ispra, Italy
Regul Toxicol Pharmacol 58:455-73. 2010b>Fullerenes have gained considerable attention due to their anti-oxidant and radical scavenging properties. Their current applications include targeted drug delivery, energy application, polymer modifications and cosmetic products...
- Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivativesTadahiko Mashino
Kyoritsu University of Pharmacy, Shibakoen 1 5 30, Minato ku, Tokyo 105 8512, Japan
Bioorg Med Chem Lett 15:1107-9. 2005..Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition...
- The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicityHelinor J Johnston
Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Edinburgh EH10 5DT, UK
Toxicol Sci 114:162-82. 2010..provides a comprehensive critical review of the available literature purporting to assess the toxicity of carbon fullerenes. This is required as prior to the widespread utilization and production of fullerenes, it is necessary to ..
- Potent angiogenesis inhibition by the particulate form of fullerene derivativesHuan Meng
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
ACS Nano 4:2773-83. 2010..We propose that using nanoscale "particulate" itself as a new form of medicine (particulate medicine) may be superior to the traditional "molecular" form of medicine (molecular medicine) in cancer treatment...
- Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubesJanne K Folkmann
Institute of Public Health, Department of Environmental Health, University of Copenhagen, Copenhagen, Denmark
Environ Health Perspect 117:703-8. 2009C60 fullerenes and single-walled carbon nanotubes (SWCNT) are projected to be used in medicine and consumer products with potential human exposure...
- Integrated thin-film polymer/fullerene photodetectors for on-chip microfluidic chemiluminescence detectionXuhua Wang
Experimental Solid State Physics Group, Blackett Laboratory, Imperial College London, UK
Lab Chip 7:58-63. 2007....
- Aqueous fullerene aggregates (nC60) generate minimal reactive oxygen species and are of low toxicity in fish: a revision of previous reportsTheodore B Henry
School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, Devon, United Kingdom
Curr Opin Biotechnol 22:533-7. 2011This review aims to clarify inconsistencies in previous reports regarding the potential for aqueous aggregates of fullerenes (nC60) to generate reactive oxygen species (ROS) and cause toxicity in fish...
- Comparison of electrokinetic properties of colloidal fullerenes (n-C60) formed using two proceduresJonathan Brant
Department of Civil and Environmental Engineering, Rice University, Mail Stop 317, Houston, Texas 77251 1892, USA
Environ Sci Technol 39:6343-51. 2005..in water without the aid of organic solvents, a pathway that may be important in determining the mobility of fullerenes in natural systems...
- Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C60)Zoran Markovic
Vinca Institute of Nuclear Sciences, Laboratory for Atomic Physics, P O Box 522, 11000 Belgrade, Serbia
Biomaterials 29:3561-73. 2008..Therefore, the dual property of fullerenes to either quench or generate cell-damaging ROS could be potentially exploited for their development as ..
- Multihydroxylated [Gd@C82(OH)22]n nanoparticles: antineoplastic activity of high efficiency and low toxicityChunying Chen
Lab for Bio Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
Nano Lett 5:2050-7. 2005..05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity...
- Effect of preparation methods on toxicity of fullerene water suspensions to Japanese medaka embryosKi Tae Kim
Department of Environmental Science and Engineering, Gwangju Institute of Science and Technology GIST, 261 Cheom dan Gwagi ro, Buk Gu, Gwangju 500 712, Republic of Korea
Sci Total Environ 408:5606-12. 2010..To summarize, these findings clearly illustrated the need to consider the effect of preparation method on the physicochemical properties when assessing nC(60) toxicity...
- Highly hydroxylated fullerene localizes at the cytoskeleton and inhibits oxidative stress in adipocytes and a subcutaneous adipose-tissue equivalentLi Xiao
Laboratory of Cell Death Control BioTechnology, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shobara, Hiroshima, Japan
Free Radic Biol Med 51:1376-89. 2011..In conclusion, HHF is able to inhibit oxidative stress in adipocytes and adipogenesis-related macrophage activation in adipose tissues through its antioxidation...
- Protective effect of C(60) -methionine derivate on lead-exposed human SH-SY5Y neuroblastoma cellsTian Chen
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
J Appl Toxicol 31:255-61. 2011..These observations suggest that FMD may serve as a potential antioxidative and neuroprotective agent in the prevention of lead intoxication...
- Recent progresses in application of fullerenes in cosmeticsMarko Lens
King s College, St Thomas s Hospital, Westminster Bridge Road, London SE1 7EH, UK
Recent Pat Biotechnol 5:67-73. 2011..Fullerene C(60) and its derivates have been subject of intensive research in the last few years. Fullerenes display a wide range of different biological activities...
- Water-soluble fullerene (C60) inhibits the development of arthritis in the rat model of arthritisKazuo Yudoh
Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan
Int J Nanomedicine 4:217-25. 2009..These findings indicate that C60 is a potential therapeutic agent for inhibition of arthritis...
- A molecular dynamics simulation study of C60 fullerenes inside a dimyristoylphosphatidylcholine lipid bilayerLiwei Li
Department of Materials Science and Engineering, University of Utah, Salt Lake City, Utah 84112, USA
J Phys Chem B 111:4067-72. 2007We have carried out atomistic molecular dynamics simulations of C60 fullerenes inside a dimyristoylphosphatidylcholine lipid bilayer and an alkane melt...
- Conjugation of functionalized gadolinium metallofullerenes with IL-13 peptides for targeting and imaging glial tumorsHelen L Fillmore
Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA
Nanomedicine (Lond) 6:449-58. 2011....
- In vivo gene delivery by cationic tetraamino fullereneRui Maeda-Mamiya
Department of Chemistry and Exploratory Research for Advanced Technology Japan Science and Technology Agency, University of Tokyo, 7 3 1 Hongo Bunkyo, Tokyo 113 0033, Japan
Proc Natl Acad Sci U S A 107:5339-44. 2010Application of nanotechnology to medical biology has brought remarkable success. Water-soluble fullerenes are molecules with great potential for biological use because they can endow unique characteristics of amphipathic property and form ..
- Toxicity of an engineered nanoparticle (fullerene, C60) in two aquatic species, Daphnia and fathead minnowShiqian Zhu
Environmental Toxicology Research Program, National Center for Natural Products Research, Department of Pharmacology, School of Pharmacy, The University of Mississippi, 347 Faser, University, MS 38677 1848, USA
Mar Environ Res 62:S5-9. 2006..2004. Manufactured nanomaterials (fullerenes, c60) induce oxidative stress in brain of juvenile largemouth bass. Environ. Health Persp...
- Antioxidant properties of fullerenol C60(OH)24 in rat kidneys, testes, and lungs treated with doxorubicinBranislava Srdjenovic
Medical Faculty, Department of Pharmacy, University of Novi Sad, Hajduk Veljkova 3, Novi Sad, Serbia
Toxicol Mech Methods 20:298-305. 2010..Results of this study support the hypothesis of testicular, pulmo-, and nephroprotective efficacy of fullerenol in preventing oxidative stress induced by doxorubicin...
- Antibacterial activity of fullerene water suspensions: effects of preparation method and particle sizeDelina Y Lyon
Department of Civil and Environmental Engineering and Department of Chemistry, Rice University, Houston, Texas 77005, USA
Environ Sci Technol 40:4360-6. 2006..This suggests the need for improved understanding of the behavior of FWS towards organisms and in the environment to determine how C60 can be safely used and disposed...
- Carboxyfullerenes localize within mitochondria and prevent the UVB-induced intrinsic apoptotic pathwayFilomena Chirico
Institute of Dermatology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
Exp Dermatol 16:429-36. 2007..Taken together, these results indicate that CF penetrate human keratinocytes, localize within mitochondria where they act both by scavenging free radicals and by protecting cells from apoptosis...
- Cationic fullerenes are effective and selective antimicrobial photosensitizersGeorge P Tegos
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, USA
Chem Biol 12:1127-35. 2005b>Fullerenes are soccer ball-shaped molecules composed of carbon atoms, and, when derivatized with functional groups, they become soluble and can act as photosensitizers...
- Effect of buckminsterfullerenes on cells of the innate and adaptive immune system: an in vitro study with human peripheral blood mononuclear cellsHanno Bunz
Department of Internal Medicine II, University of Tubingen, Germany
Int J Nanomedicine 7:4571-80. 2012..Both fullerenes did not influence T cell reactivity, with no enhanced expression of CD69 and production of T cell cytokines ..
- A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic propertiesSameh S Ali
Center for the Study of Nervous System Injury CSNSI, Department of Neurology, Washington University, St Louis, MO 63130, USA
Free Radic Biol Med 37:1191-202. 2004..These data, coupled with evidence that C3 localizes to mitochondria, suggest that C3 functionally replaces MnSOD, acting as a biologically effective SOD mimetic...
- Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of nanomedicineSeung gu Kang
Computational Biology Center, IBM Thomas J Watson Research Center, Yorktown Heights, NY 10598, USA
Proc Natl Acad Sci U S A 109:15431-6. 2012..Our findings provide insights for de novo design of nanomedicines for fatal diseases such as pancreatic cancer...
- The prolongation of the lifespan of rats by repeated oral administration of fullereneTarek Baati
UMR CNRS 8612, Universite Paris Sud XI, Rue J B Clément F92296, Chatenay Malabry, France
Biomaterials 33:4936-46. 2012..These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C(60) including cancer therapy, neurodegenerative disorders, and ageing...
- Non-destructive inhibition of metallofullerenol Gd@C(82)(OH)(22) on WW domain: implication on signal transduction pathwaySeung gu Kang
Computational Biology Center, IBM Thomas J Watson Research Center Yorktown Heights, NY 10598, USA
Sci Rep 2:957. 2012..Further analyses with binding free energy landscapes reveal that Gd@C(82)(OH)(22) can not only directly block the binding site of the WW domain, but also effectively distract the PRM from its native binding pocket...
- Characterization of surface hydrophobicity of engineered nanoparticlesYao Xiao
Department of Civil and Environmental Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA
J Hazard Mater 215:146-51. 2012..Fullerol was shown to be the least hydrophobic of seven NPs tested. The advantages and limitations of each method were also discussed...
- Modification of antioxidative and antiapoptotic genes expression in irradiated K562 cells upon fullerenol C60(OH)24 nanoparticle treatmentKarmen Stankov
Medical Faculty Novi Sad, Clinical Center of Vojvodina, University of Novi Sad, Hajduk Veljkova 1, 21000 Novi Sad, Serbia
J Nanosci Nanotechnol 13:105-13. 2013....
- Toxicity of pristine versus functionalized fullerenes: mechanisms of cell damage and the role of oxidative stressAndreja Trpkovic
Vinca Institute of Nuclear Sciences, University of Belgrade, POB 522, Belgrade, 11000, Serbia
Arch Toxicol 86:1809-27. 2012..Moreover, the widespread industrial utilization of fullerenes may also have implications for human health...
- Changes in chemiluminescence of whole blood of COPD patients treated with Hypoxen and effects of C₆₀ fullerenes on blood chemiluminescenceKirill N Novikov
Faculty of Biology, M V Lomonosov Moscow State University, Moscow, Russia
Med Sci Monit 18:BR76-83. 2012..The aim of this study was to evaluate the effect of Hypoxen treatment and the effect of HyFnC₆₀ on ROS production in patients' blood...
- Synthesis and characterization of a lithium-doped fullerane (Li(x)-C60-H(y)) for reversible hydrogen storageJoseph A Teprovich
Clean Energy Directorate, Savannah River National Lab, P O Box A, Aiken, South Carolina 29808, USA
Nano Lett 12:582-9. 2012..an onset temperature of ~270 °C, which is significantly less than the desorption temperature of hydrogenated fullerenes (C(60)H(x)) and pure lithium hydride (decomposition temperature 500-600 and 670 °C respectively)...
- Epoxyeicosatrienoic acids are involved in the C(70) fullerene derivative-induced control of allergic asthmaSarah K Norton
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA
J Allergy Clin Immunol 130:761-769.e2. 2012b>Fullerenes are molecules being investigated for a wide range of therapeutic applications...
- In vitro toxicity assessment of three hydroxylated fullerenes in human skin cellsJ G Saathoff
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27607, USA
Toxicol In Vitro 25:2105-12. 2011Carbon fullerenes possess unique properties and their interactions with biomolecules have widespread applications...
- Impacts of fullerene derivatives on regulating the structure and assembly of collagen moleculesXiaohui Yin
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences CAS, Beijing 100049, China
Nanoscale 5:7341-8. 2013..Compared to C60(OH)24, the interaction of Gd@C82(OH)22 with collagen is stronger, resulting in particular biomedical effects for regulating the biophysical properties of collagen fibrils. ..
- Uraninite and fullerene in atmospheric particulatesSatoshi Utsunomiya
Department of Nuclear Engineering and Radiological Sciences, Geological Sciences, University of Michigan, Ann Arbor, Michigan 48109 2104, USA
Environ Sci Technol 36:4943-7. 2002..We have also identified, for the first time, closely associated fullerenes, C60...
- Computational design of novel fullerene analogues as potential HIV-1 PR inhibitors: Analysis of the binding interactions between fullerene inhibitors and HIV-1 PR residues using 3D QSAR, molecular docking and molecular dynamics simulationsSerdar Durdagi
Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, 11635 Athens, Greece
Bioorg Med Chem 16:9957-74. 2008..Such structures may trigger the interest of medicinal chemists for novel HIV-1 PR inhibitors possessing higher bioactivity...
- In vitro and in vivo imaging studies of a new endohedral metallofullerene nanoparticlePanos P Fatouros
Department of Radiology, Virginia Commonwealth University, Sanger Hall, B3 021, 1101 E Marshall St, PO Box 980072, Richmond, VA 23298 0072, USA
Radiology 240:756-64. 2006....
- The effect of fullerenes and functionalized fullerenes on Daphnia magna phototaxis and swimming behaviorKathryn A Brausch
The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas, USA
Environ Toxicol Chem 30:878-84. 2011The effects of carbon fullerenes (C(60) ) on the environment is a growing concern as the use of nanotechnology continues to increase...
- Facile preparation of a new gadofullerene-based magnetic resonance imaging contrast agent with high 1H relaxivityChunying Shu
Chemistry Department, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
Bioconjug Chem 20:1186-93. 2009..The reactive carboxyl functionality present on this highly efficient contrast agent may also serve as a precursor for biomarker tissue-targeting purposes...
- Detection of a family of gadolinium-containing endohedral fullerenes and the isolation and crystallographic characterization of one member as a metal-carbide encapsulated inside a large fullerene cageHua Yang
Zhejiang California International Nanosystems Institute, Department of Chemistry, Zhejiang University, Hangzhou 310027, China
J Am Chem Soc 130:17296-300. 2008..Endohedral fullerenes of the type M(2)C(2n) can exist as the conventional endohedral, M(2)@C(2n), or as the carbide-containing ..
- Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing miceJiangxue Wang
Lab for Bio Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, P O Box 918, Beijing 100049, PR China
Biochem Pharmacol 71:872-81. 2006..The results suggest that [Gd@C82(OH)22]n nanoparticle treatment could regulate ROS production in vivo...
- Fullerene antioxidants decrease organophosphate-induced acetylcholinesterase inhibition in vitroMarion Ehrich
Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
Toxicol In Vitro 25:301-7. 2011..b>Fullerenes are carbon spheres with antioxidant activity...
- Distinct cytotoxic mechanisms of pristine versus hydroxylated fullereneAleksandra Isakovic
Institute of Biochemistry, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia and Montenegro
Toxicol Sci 91:173-83. 2006....
- Baiting proteins with C60Matteo Calvaresi
Dipartimento di Chimica G Ciamician, Universita di Bologna, V F Selmi 2, 40126 Bologna, Italy
ACS Nano 4:2283-99. 2010..A closer exam of the 10 top scorers is discussed in detail. New proteins that can interact with C60 are identified and discussed for possible future applications as drug targets and fullerene derivatives bioconjugate materials...
- Optical heating and rapid transformation of functionalized fullerenesVijay Krishna
Particle Engineering Research Center, University of Florida, Gainesville, FL 32611, USA
Nat Nanotechnol 5:330-4. 2010..Here, we show that certain functionalized fullerenes, including polyhydroxy fullerenes (which are known to be environmentally safe and to have therapeutic properties)..
- C60 binds to and deforms nucleotidesXiongce Zhao
Nanomaterials Theory Institute, Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
Biophys J 89:3856-62. 2005..Despite the hydrophobic nature of C60, our results show that fullerenes strongly bind to nucleotides...
- A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of miceKevin L Quick
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, United States
Neurobiol Aging 29:117-28. 2008..SOD mimetics with such characteristics may provide unique complements to genetic strategies to study the contribution of oxidative processes to nervous system aging...
- Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunctionDenise N Johnson-Lyles
Nanotechnology Characterization Lab NCL, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Toxicol Appl Pharmacol 248:249-58. 2010Water soluble fullerenes, such as the hydroxylated fullerene, fullerenol (C₆₀OHx), are currently under development for diagnostic and therapeutic biomedical applications in the field of nanotechnology...
- Phototoxicity and cytotoxicity of fullerol in human lens epithelial cellsJoan E Roberts
Department of Natural Sciences, Fordham University, 113 West 60th Street, New York City, NY 10023, USA
Toxicol Appl Pharmacol 228:49-58. 2008..Before fullerols are used to deliver drugs to the eye, they should be tested for photo- and cytotoxicity in vivo...
- Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticlesSarah B Lovern
University of Wisconsin Milwaukee, Great Lakes WATER Institute, 600 E Greenfield Avenue, Milwaukee, Wisconsin 53204, USA
Environ Toxicol Chem 25:1132-7. 2006..to filtered C60 and filtered TiO2 caused an increase in mortality with an increase in concentration, whereas fullerenes show higher levels of toxicity at lower concentrations...
- Toxicity studies of fullerenes and derivativesJelena Kolosnjaj
UMR CNRS 8612, Faculte de Pharmacie, Universite Paris Sud 11, Chatenay Malabry, France
Adv Exp Med Biol 620:168-80. 2007Due to their unique properties, fullerenes, a model of carbon-based nanoparticles, have attracted considerable interest in many fields of research including material science and biomedical applications...
- Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullereneGuang Jia
Department of Occupational and Environmental Health, School of Public Health, Peking University, Beijing 100083, China
Environ Sci Technol 39:1378-83. 2005..Carbon nanomaterials with different geometric structures exhibit quite different cytotoxicity and bioactivity in vitro, although they may not be accurately reflected in the comparative toxicity in vivo...
- Nano-C60 cytotoxicity is due to lipid peroxidationChristie M Sayes
Department of Chemistry, 6100 Main St MS 60, Rice University, Houston, TX 77005, USA
Biomaterials 26:7587-95. 2005..With the addition of an antioxidant, L-ascorbic acid, the oxidative damage and resultant toxicity of nano-C60 was completely prevented...
- Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bassEva Oberdörster
Duke University Marine Laboratory, Beaufort, North Carolina, USA
Environ Health Perspect 112:1058-62. 2004..It is likely that nanomaterials can affect wildlife if they are accidentally released into the environment. The fullerenes are one type of manufactured nanoparticle that is being produced by tons each year, and initially uncoated ..
- High relaxivity trimetallic nitride (Gd3N) metallofullerene MRI contrast agents with optimized functionalityJianfei Zhang
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, USA
Bioconjug Chem 21:610-5. 2010....
- Visualizing the uptake of C60 to the cytoplasm and nucleus of human monocyte-derived macrophage cells using energy-filtered transmission electron microscopy and electron tomographyAlexandra E Porter
The Nanoscience Centre, University of Cambridge, 11 JJ Thompson Avenue, Cambridge CB3 OFF, UK
Environ Sci Technol 41:3012-7. 2007..We confirm that C60 is taken up by HMMs in vitro and is sequestered at several sites within the cell. These sites include the cytoplasm, lysosomes, and most significantly the cell nuclei...
- Sonodynamically-induced anticancer effects by functionalized fullerenesNagahiko Yumita
Yokohama College of Pharmacy, 601, Matano cho, Totsuka ku, Yokohama, Kanagawa 245 0066, Japan
Anticancer Res 33:3145-51. 2013Functionalized fullerenes, such as polyhydroxy fullerenes (PHF), have attracted particular attention due to their water solubility and their potential application in tumor imaging and therapy as carbon nanomaterials...
- Photo-induced reactive oxygen species generation by different water-soluble fullerenes (C) and their cytotoxicity in human keratinocytesBaozhong Zhao
Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
Photochem Photobiol 84:1215-23. 2008..In vitro tests with HaCaT keratinocytes provided evidence that (gamma-CyD)(2)/C(60) phototoxicity is mainly mediated by (1)O(2) (Type II mechanism) with only a minor contribution from free radicals (Type I mechanism)...
- Fullerene nanomaterials inhibit phorbol myristate acetate-induced inflammationAnthony Dellinger
Luna nanoWorks, Danville, VA, USA
Exp Dermatol 18:1079-81. 2009..Oxidative stress, the generation of reactive oxygen species, is thought to be one component of this response. Fullerenes can counteract reactive oxygen species due to their potent antioxidant capabilities...
- Fullerenes: from carbon to nanomedicinePooja Chawla
Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Lucknow 227105, India
Mini Rev Med Chem 10:662-77. 2010b>Fullerenes, the third carbon allotrope, have emerged as agents which could revolutionize the treatment of many diseases...
- Passive transport of C60 fullerenes through a lipid membrane: a molecular dynamics simulation studyDmitry Bedrov
Department of Materials Science and Engineering, 122 South Central Campus Drive Room 304, University of Utah, Salt Lake City, Utah 84112, USA
J Phys Chem B 112:2078-84. 2008To investigate the implications of the unique properties of fullerenes on their interaction with and passive transport into lipid membranes, atomistic molecular dynamics simulations of a C60 fullerene in a fully hydrated di-myristoyl-..
- Structural analysis of lead fullerene-based inhibitor bound to human immunodeficiency virus type 1 protease in solution from molecular dynamics simulationsVannajan S Lee
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
J Mol Graph Model 26:558-70. 2007..The simulated results lead to the conclusion that the active site of the HIVP complexed with the diphenyl C60 alcohol is the diprotonation states on Asp25 and Asp25'...
- Use of fullerenes in cosmeticsMarko Lens
King s College, Genetic Epidemiology Unit, St Thomas s Hospital, Lambeth Palace Road, London, UK
Recent Pat Biotechnol 3:118-23. 2009..b>Fullerenes display a wide range of biological activities...
- Theoretical study on the ground state structure of uranofullerene U@C82Xin Liu
School of Chemistry, Dalian University of Technology, Dalian 116024, China
J Phys Chem A 116:11651-5. 2012..The proposed geometry and electronic structure of U(3+)@(#9)C(82)(3-) are in good agreement with the experimental observation...
- Fullerene nanomaterials inhibit the allergic responseJohn J Ryan
Department of Biology, Virginia Commonwealth University Health Systems, Richmond, VA 23294, USA
J Immunol 179:665-72. 2007b>Fullerenes are a class of novel carbon allotropes that may have practical applications in biotechnology and medicine...
- Structural and electronic properties of new fullerene derivatives and their possible application as HIV-1 protease inhibitorsMedhat Ibrahim
Spectroscopy Department, National Research Centre, Dokki, Cairo, Egyp
Spectrochim Acta A Mol Biomol Spectrosc 75:702-9. 2010..Results show that some of the investigated fullerene-based derivatives can be considered promising as HIV-1 protease inhibitors...
- Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complexMustafa Raoof
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
Biomaterials 33:2952-60. 2012....
- Gene expression of zebrafish embryos exposed to titanium dioxide nanoparticles and hydroxylated fullerenesBoris Jovanović
The College of Veterinary Medicine, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA
Ecotoxicol Environ Saf 74:1518-25. 2011..in the otic vesicle with a sublethal dose of engineered nanoparticles (titanium dioxide/TiO(2) and hydroxylated fullerenes/C(60)(OH)(24))...
- Liposomal formulation of amphiphilic fullerene antioxidantsZhiguo Zhou
Luna nanoWorks, a division of Luna Innovations Incorporated, 521 Bridge Street, Danville, VA 24541, USA
Bioconjug Chem 21:1656-61. 2010..The antioxidant property of fullerenes is retained in the bipolarly functionalized C(70) derivative, amphiphilic liposomal malonylfullerene (ALM), ..
- The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH--towards novel bacterial antiadhesivesMaxime Durka
University of Namur FUNDP, Departement de Chimie, Laboratoire de Chimie Bio Organique, Rue de Bruxelles 61, B 5000 Namur, Belgium
Chem Commun (Camb) 47:1321-3. 2011....
- Bioaccumulation of 14C60 by the earthworm Eisenia fetidaDong Li
Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, United States
Environ Sci Technol 44:9170-5. 2010Carbon fullerenes, including buckminsterfullerene (C(60)), are increasingly available for numerous applications, thus increasing the likelihood of environmental release...
- Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skinJillian G Rouse
Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Sciences, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
Nano Lett 7:155-60. 2007..TEM analysis revealed fullerene-peptide localization within the intercellular spaces of the stratum granulosum...
- Biosafety assessment of Gd@C82(OH)22 nanoparticles on Caenorhabditis elegansWendi Zhang
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
Nanoscale 3:2636-41. 2011..Our work lays the foundations for further developments of this anti-neoplastic agent for clinical applications...
- Curved pi-conjugation, aromaticity, and the related chemistry of small fullerenes (< C60) and single-walled carbon nanotubesXin Lu
State Key Laboratory of Physical Chemistry of Solid Surfaces and Center for Theoretical Chemistry, Department of Chemistry, Xiamen University, Xiamen 361005, China
Chem Rev 105:3643-96. 2005
- Enhancement of titanium dioxide photocatalysis by water-soluble fullerenesVijay Krishna
Particle Engineering Research Center, 205 Particle Science and Technology Building, PO Box 116135, University of Florida, Gainesville, FL 32611, USA
J Colloid Interface Sci 304:166-71. 2006b>Fullerenes are known for their unique electronic properties including high electron affinity...
- Comparative photoactivity and antibacterial properties of C60 fullerenes and titanium dioxide nanoparticlesLena Brunet
Department of Civil and Environmental Engineering, Rice University, Houston, Texas, USA
Environ Sci Technol 43:4355-60. 2009The production of reactive oxygen species (ROS) by aqueous suspensions of fullerenes and nano-TiO2 (Degussa P25) was measured both in ultrapure water and in minimal Davis (MD) microbial growth medium...
- Incomplete exciton harvesting from fullerenes in bulk heterojunction solar cellsGeorge F Burkhard
Department of Applied Physics, Stanford University, Stanford, California 94305, USA
Nano Lett 9:4037-41. 2009..This result has implications for most state of the art organic solar cells, since all of the most efficient devices use fullerenes as electron acceptors.
- Detection of engineered nanomaterials in drinking water, food, commercial productPaul K Westerhoff; Fiscal Year: 2010..and mass concentration of the currently most widely used inorganic NMs (Ag, TiO2, Au) and carbonaceous NMs (fullerenes and functionalized fullerenes)...
- Studies to Evaluate the Toxic Carcinogenic Potential of Test AgentsJEFFERY DILL; Fiscal Year: 2009..Keywords lung burden, fibrosis, toxicity and carcinogenicity, metal working fluids, abrasive blasting agents, fullerenes, nanomaterials, artificial butter flavorings, antimony trioxide, ortho-phthalaldehyde
- Treatment of glucocorticoid-induced osteonecrosis with nano-fullerenesQuanjun Cui; Fiscal Year: 2013..therapeutic approach toward glucocorticoid-induced osteonecrosis of the femoral head (ONFH), using nano-fullerenes which function as outstanding reactive oxygen species (ROS) scavengers...
- ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALSJacob McDonald; Fiscal Year: 2011..fiscal year (2009), studies involving the fate (in vitro and/or in vivo) of cumene, dimethylethanolamine (DMAE), fullerenes, 2',2'''-dithiobisbenzanilide (DTBBA), and 2-hydroxy-4-methoxybenzophenone (HMB), have been ..
- ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALSJacob McDonald; Fiscal Year: 2009..fiscal year (2009), studies involving the fate (in vitro and/or in vivo) of cumene, dimethylethanolamine (DMAE), fullerenes, 2[unreadable],2[unreadable][unreadable][unreadable]-dithiobisbenzanilide (DTBBA), and 2-hydroxy-4-..
- Interactions of engineered nanomaterials with lung alveolar epitheliumEDWARD DAVID CRANDALL; Fiscal Year: 2010..reports on health effects of inhaled ultrafine air pollutant particulates and other nanomaterials (especially fullerenes and their derivatives), we hypothesize that interactions between various forms of ENM (e.g., negative vs...
- Fullerenes Counteracting Organophosphorus ThreatsMarion F Ehrich; Fiscal Year: 2010..Our preliminary data show water soluble hydroxylated C60 fullerenes (C60-OH) have ability to decrease AChE inhibition in neuronal cells...
- New Stereoregular Functionalized Fullerenes as Nanomedicines for PDTLong Y Chiang; Fiscal Year: 2012..We have established some of the molecular structural features of fullerenes that mediate broad-spectrum photokilling of microbial cells and cancer cells...
- Nanoparticle Effects on Epithelial Cell Protein Expression and FunctionFrank A Witzmann; Fiscal Year: 2012DESCRIPTION (provided by applicant) Our hypothesis contends that manufactured carbon nanoparticles (fullerenes, single-walled nanotubes, and multi-walled nanotubes), when exposed to barrier epithelial (bronchiolar, intestinal, and kidney) ..
- Using Nanomaterials to Inhibit Mast Cell/Basophil-Associated DiseaseChris L Kepley; Fiscal Year: 2012..One form of nanomaterials, fullerenes, is soccer-ball-shaped carbon cages that can be functionalized and derivatized with a wide array of molecules...
- Prevention of Allergic Disease Using NanomaterialsChristopher L Kepley; Fiscal Year: 2010..One form of nanomaterials, fullerenes, is soccer-ball-shaped carbon cages that can be functionalized and derivatized with a wide array of molecules...
- Treatment of disc degeneration by nano-fullerenesXUDONG JOSHUA LI; Fiscal Year: 2012....
- Development of New Atomic-Based EPR Spin ProbesJohn M Alford; Fiscal Year: 2012..probes, we propose to investigate new types of spin probes based upon paramagnetic atoms encapsulated in C60 fullerenes that will have higher sensitivity in their ability to detect reactive oxygen species...
- Improved Spin Probes for Magnetic Resonance Imaging of Oxygen and Reactive OxygenLAURA DUGAN; Fiscal Year: 2009..probes, we propose to investigate spin probes based upon single paramagnetic nitrogen atoms encapsulated in C60 fullerenes, N@C60...
- Trimetallic Nitride Templated Endohedral Metallofullerenes as Dual Imaging and MuMARISSA RYLANDER; Fiscal Year: 2009The project objective is to investigate a novel class of fullerenes called trimetallic nitride templated endohedral metallofullerenes (TNT EMFs) as dual imaging and multimodal therapeutic agents for laser cancer therapy...
- Photodynamic Therapy of Disseminated Peritoneal Tumor Using New PhotosensitizersJ Wharton; Fiscal Year: 2009..One major advantage of our PS is that laser light is not needed. In addition, because fullerenes do not absorb red light, phototoxicity related to deep tissue penetrating light is minimized...
- INTRACELLULAR MOLECULAR ANALYSIS REQUIRED ENHANCED ION MOBILITY OTOFMS DATA ACQUJ Albert Schultz; Fiscal Year: 2009..for MALDI-IM-oTOFMS is proposed through the use of internal mass (and mobility) standards comprising giant fullerenes. Realtime calibration of Ion mobility drift times and m/z with ppm mass accuracy can be achieved using specially ..
- Free radicals detection in aging brain by fullerenesVLADIMIR DIDENKO; Fiscal Year: 2003..b>Fullerenes were discovered by a Nobel laureate Richard Smalley in1985 and are physiologically inert...
- GADOLINIUM CONTAINING FULLERENES AS MRI CONTRAST AGENTSJOHN ALFORD; Fiscal Year: 2000Endohedral fullerenes containing Gd atoms are a promising new class of compounds with the potential to be superior MRI contrast agents...
- Development of Improved Spin Probes for Aging ResearchJOHN ALFORD; Fiscal Year: 2007..we propose to investigate spin probes based upon single paramagnetic nitrogen atoms encapsulated in C60 fullerenes, N@C60...
- DEVELOPMENT OF CARBOXYFULLERENE DRUGS TO TREAT ALSJOHN ALFORD; Fiscal Year: 2003..pharmaceuticals are one of the most unique, yet important and commercially viable applications of fullerenes to date...
- RESCUE FROM NIGROSTRIATAL INJURYJoel Perlmutter; Fiscal Year: 2003..If this strategy works, these results will provide the preliminary data for a proper trial of these promising drugs in humans. ..
- Comparative In Vivo Biodistribution of Characterized Manufactured NanomaterialsNancy A Monteiro Riviere; Fiscal Year: 2010..the physicochemical interactions between MNM and biological systems by conducting in vivo ADME studies of fullerenes and single walled carbon nanotubes (SWNT) in rats and pigs, along with intensive physicochemical ..
- Improved Manufacturing Processes for Advanced Imaging AgROBERT BOLSKAR; Fiscal Year: 2005..These can help improve MRI scans used for detecting diseases and are also potentially useful for other medical treatments and applications. ..
- Cut Nanotube Capsules for MR Imaging (RMI)ROBERT BOLSKAR; Fiscal Year: 2006..unreadable] [unreadable]..
- Fullerene Immunoconjugates for Cancer Imaging and TreatmentROBERT BOLSKAR; Fiscal Year: 2008..b>Fullerenes are non-toxic carbon cage molecules with a rich derivatization chemistry useful for conjugating drug molecules, ..
- New MR Angiography Agents Using Gd@C60 NanotechnologyROBERT BOLSKAR; Fiscal Year: 2004..The new Gd-C60 compounds created in this study will fill a unique niche in angiographic MR imaging applications, for example the non-invasive detection of vascular abnormalities, while exceeding the safety levels of current Gd chelates. ..
- Superior Coatings for Semiconductor Quantum DotsROBERT BOLSKAR; Fiscal Year: 2007..Public health benefits resulting from this project will include safer, more potent means for diagnosis and treatment of disease, both in laboratory tests and for patients. [unreadable] [unreadable] [unreadable]..
- Improved Safe Alternative to Semiconductor Quantum DotsROBERT BOLSKAR; Fiscal Year: 2005..The platform for new QD agents created in this project will offer superior fluorophores for biological and medial imaging. ..
- Developing a CEST Reporter Gene (RMI)JEFF BULTE; Fiscal Year: 2008..To achieve this goal, our aim is to synthesize novel, more efficient CEST reporter genes, and to detect double-labeled LRP/ARP transfected glioma cells and neural stem cells individually in live animals. [unreadable] [unreadable]..
- A Computational Docking Resource for Cancer ResearchArthur Olson; Fiscal Year: 2006..Formal training workshops will provide training on the most popular modeling and simulation methods to the wider NCI community. This Resource will both accelerate and extend research in Cancer Biology for the NCI community. ..
- Carbon Antioxidants to Prevent Diabetic ComplicationsMICHAEL DIENER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- IRON PORPHYRIN ACTIVATION OF DIOXYGEN/SMALL MOLECULESALAN BALCH; Fiscal Year: 2004....
- Carbon Antioxidants To Prevent AtherosclerosisMICHAEL DIENER; Fiscal Year: 2003..This project will study whether carbon-based antioxidants can extend their success to LDL protection and confer their benefits in vivo for retarding atherosclerosis. ..
- Metallofullerene Nanoplatform for Imaging & TreatmentPanos Fatouros; Fiscal Year: 2009..D. WILSON, PhD, radiobiologist and Director Animal Imaging, VCU Molecular Imaging Center;H. L. FILLMORE, PhD, molecular neurobiologist, expert in tumor targeting strategies. ..
- ASN Workshop "In Vivo MR Tracking of Stem Cells in the CNS" (R13)JEFF BULTE; Fiscal Year: 2005..The outcome of the workshop will be published in Experimental Neurology and available for the scientific community at large. ..
- Molecular Cages for Alpha Particle RadioimmunotherapyMICHAEL DIENER; Fiscal Year: 2002..The development of such a therapy has a potential market of approximately 300,000 Americans/yr. ..
- Radiopharmaceuticals for Tumor Imaging and Photodynamic TherapyRavindra Pandey; Fiscal Year: 2007..unreadable] [unreadable]..
- MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet CellsJEFF BULTE; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Development/Bifunctional MR Agents/Diagnosis and TherapyRavindra Pandey; Fiscal Year: 2007..abstract_text> ..
- Drug Design Cycle Targeting HIV Protease Drug ResistanceArthur Olson; Fiscal Year: 2007..abstract_text> ..
- MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet CellsJEFF BULTE; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- TANDEM TIME-OF-FLIGHT FOR PROTEOMICS ANALYSISRobert Cotter; Fiscal Year: 2005..This technology is expected to bring high performance and tandem capabilities to a simple, compact instrument that can be utilized in proteomics research. ..
- Metabolomics: Markers of Drug-Induced Liver Injury(RMI)Susan Sumner; Fiscal Year: 2008..The signals defining these patterns will be identified using GC-MS, NMR, and LC-MS/MS methods and then assigned to biochemical pathways for defining the relevancy of the marker profiles to mode of action. ..
- Purchase of a Linear Ion Trap/Fourier Transform Mass SpectrometerRobert Cotter; Fiscal Year: 2007..The instrument will be housed in and managed by the Middle Atlantic Mass Spectrometry Laboratory and operated by four individuals representing the Major Users and collaborators. [unreadable] [unreadable] [unreadable]..
- Quantitating Absorption of Complex Chemical MixturesJim Riviere; Fiscal Year: 2009..abstract_text> ..