arsenic

Summary

Summary: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)

Top Publications

  1. ncbi RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
    Michael H Tatham
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Nat Cell Biol 10:538-46. 2008
  2. pmc Rice consumption contributes to arsenic exposure in US women
    Diane Gilbert-Diamond
    Children s Environmental Health and Disease Prevention Center at Dartmouth, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 108:20656-60. 2011
  3. ncbi Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway
    Valérie Lallemand-Breitenbach
    Université de Paris 7 CNRS UMR 7151, Equipe Labellisée N11 Ligue Nationale Contre le Cancer, Hopital St Louis, 1, Av C Vellefaux 75475 Paris CEDEX 10 France
    Nat Cell Biol 10:547-55. 2008
  4. ncbi Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML
    Xiao Wei Zhang
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road II, Shanghai 200025, China
    Science 328:240-3. 2010
  5. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003
  6. pmc Evaluation of the association between arsenic and diabetes: a National Toxicology Program workshop review
    Elizabeth A Maull
    Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:1658-70. 2012
  7. ncbi In utero arsenic exposure is associated with impaired thymic function in newborns possibly via oxidative stress and apoptosis
    Sultan Ahmed
    Institute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden
    Toxicol Sci 129:305-14. 2012
  8. pmc Long-distance transport, vacuolar sequestration, tolerance, and transcriptional responses induced by cadmium and arsenic
    David G Mendoza-Cózatl
    Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093 0116, USA
    Curr Opin Plant Biol 14:554-62. 2011
  9. pmc Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
    Konstantin Salnikow
    National Cancer Institute, Frederick, MD 21702, USA
    Chem Res Toxicol 21:28-44. 2008
  10. pmc Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    BMJ 342:d2431. 2011

Detail Information

Publications385 found, 100 shown here

  1. ncbi RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
    Michael H Tatham
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Nat Cell Biol 10:538-46. 2008
    ..This disease can be treated effectively with arsenic, which induces PML modification by small ubiquitin-like modifiers (SUMO) and proteasomal degradation...
  2. pmc Rice consumption contributes to arsenic exposure in US women
    Diane Gilbert-Diamond
    Children s Environmental Health and Disease Prevention Center at Dartmouth, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 108:20656-60. 2011
    Emerging data indicate that rice consumption may lead to potentially harmful arsenic exposure. However, few human data are available, and virtually none exist for vulnerable periods such as pregnancy...
  3. ncbi Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway
    Valérie Lallemand-Breitenbach
    Université de Paris 7 CNRS UMR 7151, Equipe Labellisée N11 Ligue Nationale Contre le Cancer, Hopital St Louis, 1, Av C Vellefaux 75475 Paris CEDEX 10 France
    Nat Cell Biol 10:547-55. 2008
    In acute promyelocytic leukaemia (APL), arsenic trioxide induces degradation of the fusion protein encoded by the PML-RARA oncogene, differentiation of leukaemic cells and produces clinical remissions...
  4. ncbi Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML
    Xiao Wei Zhang
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road II, Shanghai 200025, China
    Science 328:240-3. 2010
    b>Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide interest because it shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL)...
  5. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003
    The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. These metals have been extensively studied and their effects on human health regularly reviewed by international ..
  6. pmc Evaluation of the association between arsenic and diabetes: a National Toxicology Program workshop review
    Elizabeth A Maull
    Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:1658-70. 2012
    ..a workshop to assess the literature for evidence of associations between certain chemicals, including inorganic arsenic, and diabetes and/or obesity to help develop a focused research agenda...
  7. ncbi In utero arsenic exposure is associated with impaired thymic function in newborns possibly via oxidative stress and apoptosis
    Sultan Ahmed
    Institute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden
    Toxicol Sci 129:305-14. 2012
    Prenatal arsenic exposure is associated with increased infant morbidity and reduced thymus size, indicating arsenic-related developmental immunotoxicity...
  8. pmc Long-distance transport, vacuolar sequestration, tolerance, and transcriptional responses induced by cadmium and arsenic
    David G Mendoza-Cózatl
    Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093 0116, USA
    Curr Opin Plant Biol 14:554-62. 2011
    ..copper and manganese are essential metals for cellular enzyme functions while cadmium, mercury and the metalloid arsenic lack any biological function...
  9. pmc Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
    Konstantin Salnikow
    National Cancer Institute, Frederick, MD 21702, USA
    Chem Res Toxicol 21:28-44. 2008
    Chronic exposure to nickel(II), chromium(VI), or inorganic arsenic (iAs) has long been known to increase cancer incidence among affected individuals...
  10. pmc Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    BMJ 342:d2431. 2011
    To evaluate the association between arsenic exposure and mortality from cardiovascular disease and to assess whether cigarette smoking influences the association.
  11. pmc An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:11-9. 2011
    Exposure to arsenic, an established human carcinogen, through consumption of highly contaminated drinking water is a worldwide public health concern...
  12. pmc Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism
    Karin Engström
    Department of Laboratory Medicine, Section of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 119:182-8. 2011
    b>Arsenic (As) occurs as monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in humans, and the methylation pattern demonstrates large interindividual differences...
  13. pmc Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh
    Brandon L Pierce
    Department of Health Studies, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 8:e1002522. 2012
    b>Arsenic contamination of drinking water is a major public health issue in many countries, increasing risk for a wide array of diseases, including cancer...
  14. pmc Inorganic arsenic and basal cell carcinoma in areas of Hungary, Romania, and Slovakia: a case-control study
    Giovanni Leonardi
    Centre for Radiation, Chemical and Environmental Hazards, Health Protection Agency, Chilton, United Kingdom
    Environ Health Perspect 120:721-6. 2012
    Inorganic arsenic (iAs) is a potent carcinogen, but there is a lack of information about cancer risk for concentrations < 100 μg/L in drinking water.
  15. pmc Rice consumption and urinary arsenic concentrations in U.S. children
    Matthew A Davis
    Institute for Quantitative Biomedical Sciences, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03756, USA
    Environ Health Perspect 120:1418-24. 2012
    In adult populations, emerging evidence indicates that humans are exposed to arsenic by ingestion of contaminated foods such as rice, grains, and juice; yet little is known about arsenic exposure among children.
  16. pmc A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the Health Effects of Arsenic Longitudinal Study (HEALS)
    Faruque Parvez
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Thorax 65:528-33. 2010
    A prospective cohort study was conducted to evaluate the effect of arsenic (As) exposure from drinking water on respiratory symptoms using data from the Health Effects of Arsenic Exposure Longitudinal Study (HEALS), a large prospective ..
  17. pmc Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA
    J Richard Pilsner
    Division of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS ONE 7:e37147. 2012
    An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown.
  18. pmc Long-term low-level arsenic exposure is associated with poorer neuropsychological functioning: a Project FRONTIER study
    Sid E O'Bryant
    F Marie Hall Institute for Rural and Community Health, Texas Tech University Health Sciences Center, 3601 4th St, STOP 6323, Lubbock, TX 79430, USA
    Int J Environ Res Public Health 8:861-74. 2011
    ..Inorganic arsenic is a known neurotoxin that has both neurodevelopmental and neurocognitive consequences...
  19. pmc Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters
    Won Yong Song
    Department of Integrative Bioscience and Biotechnology, University of Zurich Cooperative Laboratory, World Class University Program, Pohang University of Science and Technology, Pohang 790 784, Korea
    Proc Natl Acad Sci U S A 107:21187-92. 2010
    b>Arsenic is an extremely toxic metalloid causing serious health problems. In Southeast Asia, aquifers providing drinking and agricultural water for tens of millions of people are contaminated with arsenic...
  20. ncbi Arsenic exposure and prevalence of type 2 diabetes in US adults
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W7033B, Baltimore, MD 21205, USA
    JAMA 300:814-22. 2008
    High chronic exposure to inorganic arsenic in drinking water has been related to diabetes development, but the effect of exposure to low to moderate levels of inorganic arsenic on diabetes risk is unknown...
  21. ncbi Fifty-year study of lung and bladder cancer mortality in Chile related to arsenic in drinking water
    Guillermo Marshall
    Departamento de Salud Publica, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Natl Cancer Inst 99:920-8. 2007
    Region II of Chile (the second most northerly administrative region) experienced dramatic increases in average arsenic water concentrations beginning in 1958, followed by marked declines in the 1970s when water treatment plants were ..
  22. ncbi Arsenic-induced oxidative stress and its reversibility
    Swaran J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Free Radic Biol Med 51:257-81. 2011
    This review summarizes the literature describing the molecular mechanisms of arsenic-induced oxidative stress, its relevant biomarkers, and its relation to various diseases, including preventive and therapeutic strategies...
  23. ncbi Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh
    Anisur Rahman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka, Bangladesh
    Am J Epidemiol 169:304-12. 2009
    The authors evaluated the association of prenatal arsenic exposure with size at birth (birth weight, birth length, head and chest circumferences)...
  24. ncbi Arsenic in drinking-water and reproductive health outcomes: a study of participants in the Bangladesh Integrated Nutrition Programme
    Richard K Kwok
    RTI International, Research Triangle Park, PO Box 12194, 3040 Cornwallis Road, NC 27709, USA
    J Health Popul Nutr 24:190-205. 2006
    This study examined 2,006 pregnant women chronically exposed to a range of naturally-occurring concentrations of arsenic in drinking-water in three upazilas in Bangladesh to find out relationships between arsenic exposure and selected ..
  25. pmc Arsenic promotes ubiquitinylation and lysosomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels in human airway epithelial cells
    Jennifer M Bomberger
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 287:17130-9. 2012
    b>Arsenic exposure significantly increases respiratory bacterial infections and reduces the ability of the innate immune system to eliminate bacterial infections...
  26. pmc Prenatal arsenic exposure and DNA methylation in maternal and umbilical cord blood leukocytes
    Molly L Kile
    Oregon State University, College of Public Health and Human Sciences, Corvallis, Oregon 97331, USA
    Environ Health Perspect 120:1061-6. 2012
    b>Arsenic is an epigenetic toxicant and could influence fetal developmental programming.
  27. pmc Association between type 2 diabetes and chronic arsenic exposure in drinking water: a cross sectional study in Bangladesh
    Rafiqul Islam
    Centre for Clinical Epidemiology and Biostatistics CCEB, The University of Newcastle, Lot 1 Kookaburra Circuit, New Lambton Heights, NSW 2305, Australia
    Environ Health 11:38. 2012
    Chronic exposure to high level of inorganic arsenic in drinking water has been associated with Type 2 Diabetes (T2D)...
  28. pmc JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure
    Jia Liu
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
    Toxicol Sci 129:363-71. 2012
    Environmental exposure to arsenic, especially the trivalent inorganic form (As(3+)), has been linked to human cancers in addition to a number of other diseases including skin lesions, cardiovascular disorders, neuropathy, and internal ..
  29. pmc Identification of catalytic residues in the As(III) S-adenosylmethionine methyltransferase
    Kavitha Marapakala
    Department of Cellular Biology and Pharmacology, Florida International University, Herbert Wertheim College of Medicine, Miami, Florida 33199, United States
    Biochemistry 51:944-51. 2012
    ..The rate-limiting step was identified as the conversion of DMAs(III) to trimethylarsine, and DMAs(III) accumulates as the principal product...
  30. pmc The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies
    Hugues De The
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 944, Equipe Labellisée par la Ligue Nationale Contre le Cancer, 2 University Paris Diderot, Sorbonne Paris Cité, Paris, France
    J Cell Biol 198:11-21. 2012
    ..APL is remarkable because of the fortuitous identification of two clinically effective therapies, RA and arsenic, both of which degrade PML/RARA oncoprotein and, together, cure APL...
  31. pmc Towards prenatal biomonitoring in North Carolina: assessing arsenic, cadmium, mercury, and lead levels in pregnant women
    Alison P Sanders
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e31354. 2012
    ..The aim of this study was to assess maternal exposure to four toxic metals (arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb)) in a cohort of pregnant women in North Carolina...
  32. ncbi Acute myocardial infarction mortality in comparison with lung and bladder cancer mortality in arsenic-exposed region II of Chile from 1950 to 2000
    Yan Yuan
    Arsenic Health Effects Research Program, University of California, Berkeley, CA 94720 7360, USA
    Am J Epidemiol 166:1381-91. 2007
    b>Arsenic in drinking water is known to be a cause of lung, bladder, and skin cancer, and some studies report cardiovascular disease effects...
  33. ncbi Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes
    Zuzana Drobna
    Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 201:166-77. 2004
    Liver is a prime site for conversion of inorganic arsenic (iAs) to methylated metabolites, including methylarsenicals (MAs) and dimethylarsenicals (DMAs)...
  34. pmc Arsenic-associated oxidative stress, inflammation, and immune disruption in human placenta and cord blood
    Sultan Ahmed
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Environ Health Perspect 119:258-64. 2011
    b>Arsenic (As) exposure during pregnancy induces oxidative stress and increases the risk of fetal loss and low birth weight.
  35. ncbi A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19
    Toru Hayakawa
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
    Arch Toxicol 79:183-91. 2005
    The metabolism of arsenic is generally accepted to proceed by repetitive reduction and oxidative methylation; the latter is mediated by arsenic methyltransferase (Cyt19)...
  36. ncbi Effects of in utero arsenic exposure on child immunity and morbidity in rural Bangladesh
    Rubhana Raqib
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Toxicol Lett 185:197-202. 2009
    Chronic exposure to arsenic, a potent carcinogen and toxicant, via drinking water is a worldwide public health problem...
  37. pmc Contamination of drinking-water by arsenic in Bangladesh: a public health emergency
    A H Smith
    School of Public Health, University of California, Berkeley 94720 7360, USA
    Bull World Health Organ 78:1093-103. 2000
    The contamination of groundwater by arsenic in Bangladesh is the largest poisoning of a population in history, with millions of people exposed...
  38. pmc Low-dose arsenic compromises the immune response to influenza A infection in vivo
    Courtney D Kozul
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Environ Health Perspect 117:1441-7. 2009
    b>Arsenic exposure is a significant worldwide environmental health concern...
  39. ncbi The ecology of arsenic
    Ronald S Oremland
    U S Geological Survey, Mailstop 480, 345 Middlefield Road, Menlo Park, CA 94025, USA
    Science 300:939-44. 2003
    b>Arsenic is a metalloid whose name conjures up images of murder. Nonetheless, certain prokaryotes use arsenic oxyanions for energy generation, either by oxidizing arsenite or by respiring arsenate...
  40. ncbi Arsenic: toxicity, oxidative stress and human disease
    K Jomova
    Department of Chemistry, Faculty of Natural Sciences, Constantine the Philosopher University, Nitra, Slovakia
    J Appl Toxicol 31:95-107. 2011
    b>Arsenic (As) is a toxic metalloid element that is present in air, water and soil. Inorganic arsenic tends to be more toxic than organic arsenic...
  41. ncbi Urinary arsenic concentration adjustment factors and malnutrition
    Barbro Nermell
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Res 106:212-8. 2008
    This study aims at evaluating the suitability of adjusting urinary concentrations of arsenic, or any other urinary biomarker, for variations in urine dilution by creatinine and specific gravity in a malnourished population...
  42. pmc Arsenate reductases in prokaryotes and eukaryotes
    Rita Mukhopadhyay
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Environ Health Perspect 110:745-8. 2002
    The ubiquity of arsenic in the environment has led to the evolution of enzymes for arsenic detoxification. An initial step in arsenic metabolism is the enzymatic reduction of arsenate [As(V)] to arsenite [As(III)]...
  43. ncbi Public health. Worldwide occurrences of arsenic in ground water
    D Kirk Nordstrom
    Water Resources Division, U S Geological Survey, Boulder, CO 80303, USA
    Science 296:2143-5. 2002
  44. ncbi Gene polymorphisms of glutathione S-transferase omega 1 and 2, urinary arsenic methylation profile and urothelial carcinoma
    Chi Jung Chung
    School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan
    Sci Total Environ 409:465-70. 2011
    Genetic polymorphisms in arsenic-metabolizing enzymes may be involved in the biotransformation of inorganic arsenic and may increase the risk of developing urothelial carcinoma (UC)...
  45. ncbi ArxA, a new clade of arsenite oxidase within the DMSO reductase family of molybdenum oxidoreductases
    Kamrun Zargar
    Departments of Microbiology and Environmental Toxicology Biomolecular Engineering, University of California Santa Cruz, CA 95064, USA
    Environ Microbiol 14:1635-45. 2012
    ..led to the identification of additional arxA-like sequences in Mono Lake and Hot Creek sediments, both arsenic-rich environments in California...
  46. pmc Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression
    Wensheng Yan
    Comparative Oncology Laboratory, University of California, Davis, California 95616, USA
    J Biol Chem 286:17478-86. 2011
    ..b>Arsenic trioxide, a drug for patients with acute promyelocytic leukemia, is found to target and degrade a class of ..
  47. ncbi Low-level arsenic exposure, AS3MT gene polymorphism and cardiovascular diseases in rural Texas counties
    Gordon Gong
    F Marie Hall Institute for Rural and Community Health, Texas Tech University Health Science Center, 3601 4th Street, STOP 6232, Lubbock, TX 79430 6232, USA
    Environ Res 113:52-7. 2012
    ..Exposure to low-level (around the current U.S. standard 10 μg/L) arsenic in drinking water is associated with increased mortality of cardiovascular diseases...
  48. pmc Structure of an As(III) S-adenosylmethionine methyltransferase: insights into the mechanism of arsenic biotransformation
    A Abdul Ajees
    Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, 33199, United States
    Biochemistry 51:5476-85. 2012
    Enzymatic methylation of arsenic is a detoxification process in microorganisms but in humans may activate the metalloid to more carcinogenic species...
  49. ncbi Water-dispersible magnetite-reduced graphene oxide composites for arsenic removal
    Vimlesh Chandra
    Center for Superfunctional Materials, Department of Chemistry, Pohang University of Science and Technology, Pohang 790 784, Korea
    ACS Nano 4:3979-86. 2010
    ..Since the composites show near complete (over 99.9%) arsenic removal within 1 ppb, they are practically usable for arsenic separation from water.
  50. ncbi Microbial responses to environmental arsenic
    David Páez-Espino
    Centro Nacional de Biotecnologia CSIC, Campus de Cantoblanco, Madrid, Spain
    Biometals 22:117-30. 2009
    Microorganisms have evolved dynamic mechanisms for facing the toxicity of arsenic in the environment...
  51. pmc Arsenic exposure and hypertension: a systematic review
    Lalita N Abhyankar
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Health Perspect 120:494-500. 2012
    Environmental exposure to arsenic has been linked to hypertension in persons living in arsenic-endemic areas.
  52. ncbi What is the best biomarker to assess arsenic exposure via drinking water?
    Nathalie Marchiset-Ferlay
    Universite d Auvergne, Faculte de Pharmacie, Laboratoire Santé Publique et Environnement, 28 Place Henri Dunant, BP 38, F 63001 Clermont Ferrand Cedex, France
    Environ Int 39:150-71. 2012
    b>Arsenic (As) is a ubiquitous element. The current WHO guideline for As in drinking water is 10 μg/L. Furthermore, about 130 million people have only access to drinking water containing more than 10 g As/L...
  53. pmc Effects of arsenic exposure on DNA methylation and epigenetic gene regulation
    John F Reichard
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, 3223 Eden Avenue, Cincinnati, OH 45267 0056, USA
    Epigenomics 2:87-104. 2010
    b>Arsenic is a nonmutagenic human carcinogen that induces tumors through unknown mechanisms. A growing body of evidence suggests that its carcinogenicity results from epigenetic changes, particularly in DNA methylation...
  54. ncbi Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Expo Sci Environ Epidemiol 16:191-205. 2006
    Health Effects of Arsenic Longitudinal Study (HEALS), a multidisciplinary and large prospective cohort study in Araihazar, Bangladesh, was established to evaluate the effects of full-dose range arsenic (As) exposure on various health ..
  55. ncbi Inorganic arsenic exposure and its relation to metabolic syndrome in an industrial area of Taiwan
    Shu Li Wang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taiwan, ROC
    Environ Int 33:805-11. 2007
    Past arsenic exposure was found associated with increased incidence of type 2 diabetes. However, the mechanisms remain unclear. Metabolic syndrome has been shown as a strong predictor for diabetes occurrence...
  56. ncbi Arsenic induces pancreatic β-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways
    Tien Hui Lu
    Graduate Institute of Drug Safety, College of Pharmacy, China Medical University, Taichung 404, Taiwan
    Toxicol Lett 201:15-26. 2011
    b>Arsenic (As), a ubiquitous toxic metal, is an important environmental and industrial pollutant throughout the world. Inorganic As (iAs) is usually more harmful than organic ones and with a high risk of diabetes incidence by exposure...
  57. pmc Arsenic, organic foods, and brown rice syrup
    Brian P Jackson
    Trace Element Analysis Core Laboratory, Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Environ Health Perspect 120:623-6. 2012
    Rice can be a major source of inorganic arsenic (Asi) for many sub-populations. Rice products are also used as ingredients in prepared foods, some of which may not be obviously rice based...
  58. ncbi Arsenic methylation efficiency increases during the first trimester of pregnancy independent of folate status
    Renee M Gardner
    Institute of Environmental Medicine, Karolinska Institute, P O Box 210, 17177 Stockholm, Sweden
    Reprod Toxicol 31:210-8. 2011
    Exposure to inorganic arsenic during pregnancy may negatively influence the offspring, though efficient metabolism of arsenic to dimethylarsinic acid (DMA) likely reduces the health risks...
  59. pmc Maternal arsenic exposure and impaired glucose tolerance during pregnancy
    Adrienne S Ettinger
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:1059-64. 2009
    Accumulating evidence has shown an increased risk of type 2 diabetes in general populations exposed to arsenic, but little is known about exposures during pregnancy and the association with gestational diabetes (GD).
  60. pmc Role and mechanism of arsenic in regulating angiogenesis
    Ling Zhi Liu
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e20858. 2011
    b>Arsenic is a wide spread carcinogen associated with several kinds of cancers including skin, lung, bladder, and liver cancers. Lung is one of the major targets of arsenic exposure...
  61. ncbi Critical windows of exposure for arsenic-associated impairment of cognitive function in pre-school girls and boys: a population-based cohort study
    J D Hamadani
    International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Int J Epidemiol 40:1593-604. 2011
    Exposure to arsenic through drinking water has been associated with impaired cognitive function in school-aged children in a few cross-sectional studies; however, there is little information on critical windows of exposure.
  62. ncbi Association between urinary arsenic and diabetes mellitus in the Korean general population according to KNHANES 2008
    Yangho Kim
    Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea
    Sci Total Environ 409:4054-62. 2011
    We present data from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008 on the associations between urinary arsenic and diabetes mellitus in a representative sample of the adult Korean population.
  63. ncbi Mechanisms to cope with arsenic or cadmium excess in plants
    Nathalie Verbruggen
    Laboratoire de Physiologie et de Génétique Moléculaire des Plantes, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium
    Curr Opin Plant Biol 12:364-72. 2009
    The metalloid arsenic and the heavy metal cadmium have no demonstrated biological function in plants. Both elements are highly toxic and of major concern with respect to their accumulation in soils, in the food-chain or in drinking water...
  64. pmc Effects of arsenic exposure on DNA methylation in cord blood samples from newborn babies and in a human lymphoblast cell line
    Ponpat Intarasunanont
    Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Bangkok, 10210, Thailand
    Environ Health 11:31. 2012
    Accumulating evidence indicates that in utero exposure to arsenic is associated with congenital defects and long-term disease consequences including cancers...
  65. pmc Persistent exposure to arsenic via drinking water in rural Bangladesh despite major mitigation efforts
    Renee Gardner
    Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Am J Public Health 101:S333-8. 2011
    Elevated arsenic levels in tube-well water in Bangladesh have prompted extensive mitigation projects...
  66. pmc Arsenic metabolism by human gut microbiota upon in vitro digestion of contaminated soils
    Tom Van de Wiele
    Ghent University, Belgium
    Environ Health Perspect 118:1004-9. 2010
    Speciation analysis is essential when evaluating risks from arsenic (As) exposure...
  67. pmc Effect of arsenic exposure during pregnancy on infant development at 7 months in rural Matlab, Bangladesh
    Fahmida Tofail
    Child Development Unit, Clinical Sciences Division and Public Health Sciences Division, International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Environ Health Perspect 117:288-93. 2009
    Exposure to arsenic-contaminated drinking water during pregnancy is associated with low birth weight and fetal loss, and there is concern that the infants' development may be affected.
  68. ncbi Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions
    Karin Schläwicke Engström
    Department of Laboratory Medicine, Section of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Mutat Res 667:4-14. 2009
    The susceptibility to arsenic (As)-induced diseases differs greatly between individuals, probably to a large extent due to genetic differences in arsenic metabolism...
  69. pmc Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress
    Jingqi Fu
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:864-70. 2010
    Chronic exposure of humans to inorganic arsenic, a potent environmental oxidative stressor, is associated with incidence of type 2 diabetes (T2D)...
  70. pmc Requirement of arsenic biomethylation for oxidative DNA damage
    Chikara Kojima
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 101:1670-81. 2009
    Inorganic arsenic is an environmental carcinogen that may act through multiple mechanisms including formation of methylated derivatives in vivo. Sodium arsenite (up to 5...
  71. pmc Impact of smoking and chewing tobacco on arsenic-induced skin lesions
    Anna Lena Lindberg
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 118:533-8. 2010
    We recently reported that the main reason for the documented higher prevalence of arsenic-related skin lesions among men than among women is the result of less efficient arsenic metabolism.
  72. pmc Health effects of arsenic and chromium in drinking water: recent human findings
    Allan H Smith
    School of Public Health, University of California, Berkeley, California 94720, USA
    Annu Rev Public Health 30:107-22. 2009
    Even at high concentrations, arsenic-contaminated water is translucent, tasteless, and odorless...
  73. pmc Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions
    Olga L Valenzuela
    Toxicologia, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional CINVESTAV IPN, Av IPN 2508, San Pedro Zacatenco, Mexico D F, C P 07360, Mexico
    Toxicol Appl Pharmacol 239:200-7. 2009
    Exposure to naturally occurring inorganic arsenic (iAs), primarily from contaminated drinking water, is considered one of the top environmental health threats worldwide...
  74. pmc Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
    Luz M Del Razo
    Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico DF, Mexico
    Environ Health 10:73. 2011
    Human exposures to inorganic arsenic (iAs) have been linked to an increased risk of diabetes mellitus. Recent laboratory studies showed that methylated trivalent metabolites of iAs may play key roles in the diabetogenic effects of iAs...
  75. pmc Arsenic exposure in pregnancy increases the risk of lower respiratory tract infection and diarrhea during infancy in Bangladesh
    Anisur Rahman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Environ Health Perspect 119:719-24. 2011
    Previous studies have reported associations between prenatal arsenic exposure and increased risk of infant mortality...
  76. ncbi Maternal arsenic exposure associated with low birth weight in Bangladesh
    Karen L Huyck
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Occup Environ Med 49:1097-104. 2007
    To characterize the effects of maternal arsenic exposure on birth weight.
  77. pmc The chromosomal arsenic resistance genes of Thiobacillus ferrooxidans have an unusual arrangement and confer increased arsenic and antimony resistance to Escherichia coli
    B G Butcher
    Department of Microbiology, University of Stellenbosch, Matieland, South Africa 7602
    Appl Environ Microbiol 66:1826-33. 2000
    The chromosomal arsenic resistance genes of the acidophilic, chemolithoautotrophic, biomining bacterium Thiobacillus ferrooxidans were cloned and sequenced...
  78. ncbi Health effects of early life exposure to arsenic
    Marie Vahter
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Basic Clin Pharmacol Toxicol 102:204-11. 2008
    Inorganic arsenic is a potent human carcinogen and general toxicant. More than one hundred million people are exposed to elevated concentrations, mainly via drinking water, but also via industrial emissions...
  79. ncbi Arsenic and selenium in microbial metabolism
    John F Stolz
    Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    Annu Rev Microbiol 60:107-30. 2006
    b>Arsenic and selenium are readily metabolized by prokaryotes, participating in a full range of metabolic functions including assimilation, methylation, detoxification, and anaerobic respiration...
  80. ncbi Arsenic in drinking water and adult mortality: a population-based cohort study in rural Bangladesh
    Nazmul Sohel
    Department of Women s and Children s Health, International Maternal and Child Health IMCH, Uppsala University, Uppsala, Sweden
    Epidemiology 20:824-30. 2009
    b>Arsenic is a potent human carcinogen and toxicant. Elevated concentration of arsenic in drinking water is a major public-health problem worldwide...
  81. pmc Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in
    Yu Chen
    Departments of Environmental Medicine and Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY, USA
    Toxicol Appl Pharmacol 239:184-92. 2009
    The contamination of groundwater by arsenic in Bangladesh is a major public health concern affecting 35-75 million people...
  82. ncbi Arsenic exposure and risk of spontaneous abortion, stillbirth, and infant mortality
    Anisur Rahman
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Epidemiology 21:797-804. 2010
    Millions of people worldwide are drinking water with elevated arsenic concentrations. Epidemiologic studies, mainly cross-sectional in design, have suggested that arsenic in drinking water may affect pregnancy outcome and infant health...
  83. pmc Prevalence of chronic diseases in adults exposed to arsenic-contaminated drinking water
    Kristina M Zierold
    Department of Environmental Health Sciences, Arnold School of Public Health, 800 Sumter St, University of South Carolina, Columbia, SC 29208, USA
    Am J Public Health 94:1936-7. 2004
    Inorganic arsenic is naturally occurring in groundwaters throughout the United States. This study investigated arsenic exposure and self-report of 9 chronic diseases...
  84. ncbi The risk of arsenic induced skin lesions in Bangladeshi men and women is affected by arsenic metabolism and the age at first exposure
    Anna Lena Lindberg
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Toxicol Appl Pharmacol 230:9-16. 2008
    It is known that a high fraction of methylarsonate (MA) in urine is a risk modifying factor for several arsenic induced health effects, including skin lesions, and that men are more susceptible for developing skin lesions than women...
  85. pmc Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels
    Claire de Burbure
    Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Catholic University of Louvain, Clos Chapelle aux Champs 30, B 1200 Brussels, Belgium
    Environ Health Perspect 114:584-90. 2006
    Lead, cadmium, mercury, and arsenic are common environmental pollutants in industrialized countries, but their combined impact on children's health is little known...
  86. ncbi Trace elements and cancer risk: a review of the epidemiologic evidence
    Stephanie A Navarro Silvera
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Room 1301a, New York, NY 10461, USA
    Cancer Causes Control 18:7-27. 2007
    ..Trace elements, such as selenium, zinc, arsenic, cadmium, and nickel, are found naturally in the environment, and human exposure derives from a variety of ..
  87. pmc Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Ave, B1, New York, NY 10032 USA
    Environ Health Perspect 117:254-60. 2009
    b>Arsenic methylation relies on folate-dependent one-carbon metabolism and facilitates urinary As elimination...
  88. pmc Reduction of arsenate to arsenite by the ArsC protein of the arsenic resistance operon of Staphylococcus aureus plasmid pI258
    G Ji
    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago 60680
    Proc Natl Acad Sci U S A 89:9474-8. 1992
    The arsenic resistance operon of Staphylococcus aureus plasmid pI258 consists of three genes, arsR (encoding the repressor regulatory protein), arsB (the determinant of the membrane efflux protein that confers resistance by pumping ..
  89. ncbi Attenuation of arsenic neurotoxicity by curcumin in rats
    Rajesh S Yadav
    Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, New Delhi, Post Box 80, MG Marg, Lucknow 226001, India
    Toxicol Appl Pharmacol 240:367-76. 2009
    In view of continued exposure to arsenic and associated human health risk including neurotoxicity, neuroprotective efficacy of curcumin, a polyphenolic antioxidant, has been investigated in rats...
  90. ncbi Arsenic toxicology: five questions
    H Vasken Aposhian
    Department of Molecular and Cellular Biology, The University of Arizona, Life Sciences South, Room 444, P O Box 210106, Tucson, Arizona 85721 0106, USA
    Chem Res Toxicol 19:1-15. 2006
  91. pmc JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic
    Bailing Chen
    Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA
    Cell Cycle 12:112-21. 2013
    The molecular mechanisms by which arsenic (As ( 3+) ) causes human cancers remain to be fully elucidated...
  92. pmc Urine arsenic and hypertension in US adults: the 2003-2008 National Health and Nutrition Examination Survey
    Miranda R Jones
    Department of Epidemiology, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Epidemiology 22:153-61. 2011
    High chronic exposure to inorganic arsenic may contribute to the development of hypertension...
  93. ncbi Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic
    Craig Steinmaus
    Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, California, USA
    J Toxicol Environ Health A 70:159-70. 2007
    Methylation is the primary route of metabolism of inorganic arsenic in humans, and previous studies showed that interindividual differences in arsenic methylation may have important impacts on susceptibility to arsenic-induced cancer...
  94. ncbi In vitro study of transporters involved in intestinal absorption of inorganic arsenic
    Marta Calatayud
    Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Av Agustín Escardino, 7, 46980 Paterna, Valencia, Spain
    Chem Res Toxicol 25:446-53. 2012
    Inorganic arsenic (iAs) [As(III)+As(V)] is a drinking water contaminant, and human exposure to these arsenic species has been linked with a wide range of health effects...
  95. ncbi Characterization of the active bacterial community involved in natural attenuation processes in arsenic-rich creek sediments
    Odile Bruneel
    Laboratoire Hydrosciences Montpellier, UMR5569 CNRS IRD Universités Montpellier I et II, Universite Montpellier II, cc MSE, Place Eugene Bataillon, 34095 Montpellier Cedex 05, France
    Microb Ecol 61:793-810. 2011
    ..mine drainage of the Carnoulès mine (France) is characterized by acid waters containing high concentrations of arsenic and iron...
  96. ncbi Long-term impact of arsenic in drinking water on bladder cancer health care and mortality rates 20 years after end of exposure
    Mario I Fernández
    Department of Urology, Hospital Militar, Santiago de Chile, Chile
    J Urol 187:856-61. 2012
    In this study we assessed bladder cancer health care and mortality trends in recent decades in a well studied arsenic exposed area in Northern Chile.
  97. ncbi Arsenic pollution sources
    Hemda Garelick
    Department of Natural Sciences, School of Health and Social Sciences, Middlesex University, The Burroughs, London NW4 4BT, UK
    Rev Environ Contam Toxicol 197:17-60. 2008
    b>Arsenic is a widely dispersed element in the Earth's crust and exists at an average concentration of approximately 5 mg/kg. There are many possible routes of human exposure to arsenic from both natural and anthropogenic sources...
  98. ncbi Arsenic in public water supplies and cardiovascular mortality in Spain
    M A José Medrano
    Centro Nacional de Epidemiologia, Instituto de Salud Carlos III, Sinesio Delgado 6, 28029 Madrid, Spain
    Environ Res 110:448-54. 2010
    High-chronic arsenic exposure in drinking water is associated with increased cardiovascular disease risk. At low-chronic levels, as those present in Spain, evidence is scarce...
  99. pmc Arsenic and cardiovascular disease
    J Christopher States
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40292, USA
    Toxicol Sci 107:312-23. 2009
    Chronic arsenic exposure is a worldwide health problem. Although arsenic-induced cancer has been widely studied, comparatively little attention has been paid to arsenic-induced vascular disease...
  100. ncbi A bacterium that can grow by using arsenic instead of phosphorus
    Felisa Wolfe-Simon
    NASA Astrobiology Institute, USA
    Science 332:1163-6. 2011
    ..a bacterium, strain GFAJ-1 of the Halomonadaceae, isolated from Mono Lake, California, that is able to substitute arsenic for phosphorus to sustain its growth...
  101. pmc Association of arsenic exposure with lung cancer incidence rates in the United States
    Joseph J Putila
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America
    PLoS ONE 6:e25886. 2011
    Although strong exposure to arsenic has been shown to be carcinogenic, its contribution to lung cancer incidence in the United States is not well characterized. We sought to determine if the low-level exposures to arsenic seen in the U.S...

Research Grants76

  1. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..of bio-essential metals (iron, copper, and zinc) as well as toxic trace elements (mercury, lead, cadmium, and arsenic) are known to be associated with many health disorders such as cancer, cognitive impairment, and neurological ..
  2. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Arsenic trioxide (As2O3) is a drug used world-wide that induces complete clinical remission in 90% of APL patients ..
  3. Transplacental Arsenic Induced Hepatic Dysfunction and Vascular Disease
    J Christopher States; Fiscal Year: 2010
    Cardiovascular disease is the major cause of death in the U.S. Chronic arsenic ingestion causes atherosclerosis and is associated with increased mortality from myocardial infarction and stroke...
  4. Arsenic Exposure, Genetic Determinants and Diabetes Risk in a Family Study
    Ana Navas-Acien; Fiscal Year: 2013
    ..by applicant): Background: Increasing epidemiologic and experimental evidence supports the role of inorganic arsenic in the development of diabetes...
  5. Interrelationships among nutrients involved in one-carbon metabolism in Banglades
    MEGAN NINA HALL; Fiscal Year: 2011
    ..research, investigating the influence of nutrients involved in one-carbon metabolism on the methylation of both arsenic (As) and genomic DNA. Specifically, the roles of two nutrients, choline and betaine, i.e...
  6. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..50 contamination events nationwide attributed to 8 trace elements and heavy metals such as copper, sulfur, lead, arsenic, zinc, selenium and 9 phosphorus...
  7. Arsenic, Histone Modification, and Transcription
    LYNN SHELDON; Fiscal Year: 2009
    Long term exposure to low levels of arsenic is associated with multiple diseases including skin, lung, liver, and prostate cancers, as well as metabolic disorders including hypertension and diabetes...
  8. Developing a murine model for arsenic-induced skin neoplasm
    Mohammad Athar; Fiscal Year: 2010
    It is known that about 15 million Americans are chronically exposed to environmental arsenic whereas the global picture of arsenic exposure is much grimmer as more than 100 million humans throughout the world consume arsenic ..
  9. Arsenic co-carcinogenesis with UVR: nitrosation and oxidation of target proteins
    Ke Jian Liu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Widespread human exposure to arsenic through drinking water at levels in excess of the Environmental Protection Agency and World Health Organization minimum contaminant level of 10 [unreadable]g/L is ..
  10. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010
    ..a pilot age and sex matched case-control study to investigate whether environmental exposures to mercury, lead, arsenic and cadmium play a role in autism...
  11. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..studied, the neurotoxicities and dose-effect relationships associated with other heavy metals, such as arsenic (As) and manganese (Mn), are poorly understood...
  12. The Toxic Environment and the Epigenetics of Fetal Growth
    HEATHER HERSON BURRIS; Fiscal Year: 2013
    ..provide her with the structure and support necessary to accomplish the following goals: (1) assess the role that arsenic plays in fetal growth;(2) assess the role arsenic plays in the DNA methylation of genes involved in fetal growth ..
  13. Epigenetic Changes in the Glucocorticoid Receptor Gene Due to Arsenic Exposure
    Andrea M Allan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arsenic is one of the most common naturally occurring environment contaminants, and while most studies have focused on its carcinogenic potential, a few studies have shown that arsenic adversely ..
  14. Mechanisms of arsenic-induced chromosomal instability and carcinogenesis
    Wei Dai; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic exposure to arsenic is highly associated with the occurrence of several types of malignancies, including skin, lung and bladder cancer...
  15. Epidemiological Research on Autism in Jamaica - Phase II
    Mohammad H Rahbar; Fiscal Year: 2013
    ..to investigate the role of the glutathione-S-transferase (GST) genes and five heavy metals (lead, mercury, arsenic, cadmium, manganese) in relation to ASD...
  16. FASEB SRC on Hematopoietic Malignancies
    MICHELLE ALICE KELLIHER; Fiscal Year: 2011
    ..g. Notch inhibitors in T-ALL;mechanisms of Gleevec resistance and sensitivity in chronic myeloid leukemia, use of arsenic trioxide in APL and CLL, and efforts to utilize JAK inhibitors in myeloproliferative neoplasms...
  17. Mechanisms of Arsenic-Induced Developmental Toxicity
    Lisa Bain; Fiscal Year: 2009
    b>Arsenic is an enormous public health problem as it is a contaminant of drinking water in many parts of the world...
  18. Bangladesh Centre for Global Environmental and Occupational Health
    Dewan Shamsul Alam; Fiscal Year: 2013
    ..The WHO has designated arsenic in drinking water in Bangladesh as the largest mass poisoning event in human history...
  19. Pilot Study of Arsenic, UV and Melanoma in a Non-Hispanic White Population
    Janice W Yager; Fiscal Year: 2011
    ..This pilot study addresses the question of whether past and present environmental arsenic exposure act together with UV exposure to impact risk of melanoma in the New Mexico non-Hispanic white population...
  20. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2012
    ..Millions of people in various geographical regions, including the US, are exposed to unsafe levels of inorganic arsenic (iAs) in drinking water...
  21. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..based upon a growing epidemiological literature, by us and others, indicating that exposure to lead, cadmium, or arsenic increases cardiovascular risk...
  22. System for Decontaminating Well Water for Drinking
    GIRISH SRINIVAS; Fiscal Year: 2010
    ..g. lead), organic contaminants (e.g. pesticides), as well as trace amounts of hazardous materials such as arsenic, perchlorate, nitrates and nitrites...
  23. Nutrients involved 1-carbon metabolism and the methylation of arsenic and DNA
    MEGAN NINA HALL; Fiscal Year: 2013
    ..research, investigating the influence of nutrients involved in one-carbon metabolism on the methylation of both arsenic (As) and genomic DNA. Specifically, the roles of two nutrients, choline and betaine - i.e...
  24. Toxic Metal Complexation by de Novo Designed Peptides
    Vincent L Pecoraro; Fiscal Year: 2013
    Abstract Heavy metal poisoning by elements such as mercury, lead, cadmium, and arsenic is a significant human health problem...
  25. Epigenomic impact of diet and toxicant exposure in Alzheimers disease etiology
    Iliya Lefterov; Fiscal Year: 2013
    ..Equally important, exposure to some toxic environmental factors, such as drinking water arsenic (As), induces changes that are indistinguishable from, or coincide with pathological and clinical features of AD ..
  26. Therapeutic Intervention of Lewisite-Mediated Cutaneous Blistering-Inflammation
    Mohammad Athar; Fiscal Year: 2013
    ..acute inflammation is mediated through the activation of unfolded protein response (UPR) signaling triggered by arsenic-dependent reactive oxygen species (ROS) production and activation of DNA damage response signaling...
  27. Developmental arsenic exposure causes obesity, liver disease and hyperglycemia in
    Rebecca J Sommer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): There is increasing evidence that early-life exposures to inorganic arsenic can cause disease later in life...
  28. Mechanisms for Arsenic-Induced Vascular Disease
    Aaron Barchowsky; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chronic exposure to trivalent arsenic (As III) is well known to cause cardiovascular diseases...
  29. The Role of Cytokine Signaling in Arsenic Induced Insulin Resistance
    INGRID DRUWE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Arsenic is a naturally occuring metal that has contaminated the ground water of Western, Midwestern and Northeastern areas of the United States, largely as a result of minerals dissolving from ..
  30. Arsenic Exposure, Cardiovascular Disease and Diabetes in Native Americans
    Ana Navas-Acien; Fiscal Year: 2011
    Despite suggestive experimental and epidemiologic evidence at high-chronic arsenic exposure (>=100 ug/L in drinking water), the effects of low and moderate chronic arsenic exposure on cardiovascular and diabetes risk are unknown...
  31. An Appearance-Based Intervention to Reduce Teen Skin Cancer Risk
    Joel J Hillhouse; Fiscal Year: 2013
    ..assigned indoor tanning to its highest cancer risk category, "carcinogenic to humans", joining asbestos, tobacco, arsenic and mustard gas...
  32. Field-Deployable Monitor to Assess Personal Exposure to Multiple Heavy Metals
    BADAWI M DWEIK; Fiscal Year: 2010
    ..project is to develop a portable, self-contained, easy-to-use monitor for simultaneous on-site measurement of arsenic, cadmium, manganese and lead metals from a single urine sample, in near real time, to assess personal exposure...
  33. A Study of Telomeres in an Arsenic-Exposed Bangladesh Cohort
    BRANDON LEE PIERCE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic arsenic exposure from drinking water is a serious public health issue in the U.S...
  34. Early-life arsenic exposure and adult mortality in Region II, Chile
    Allan H Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Early life arsenic exposure and adult mortality in Region II, Chile Millions of people in the US and worldwide are exposed to high concentrations of arsenic in their drinking water, and the estimated ..
  35. Biomarkers for Arsenic Toxicity: Genetics, Epigenetics and Folate
    MARY VELESCA GAMBLE; Fiscal Year: 2013
    ..Current estimates indicate that as many as 100 million people in over 70 countries are drinking water with arsenic (As) concentrations up to 100 times the World Health Organization (WHO) guideline of 10 ug per liter...
  36. Exploring arsenic and its metabolites in a transgenic model
    Iain L Cartwright; Fiscal Year: 2010
    Among the most serious issues confronting the global public health community is the long term consequence of arsenic ingestion in drinking water, a situation that has affected an estimated 100 million people worldwide, albeit ..
  37. CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENAL TOXICOLOGY PROGRAM
    Reshan Fernando; Fiscal Year: 2010
    ..in a population of Pima Indians, 350 serum samples, collected from the study, were analyzed for total and organic arsenic. In support of the NTP targeted testing program, 4 of 12 chemicals scheduled for liver toxicity testing were ..
  38. Bladder Cancer Prognostic Indicators
    Angeline Andrew; Fiscal Year: 2009
    ..of a) constitutional genetic variation in the DNA repair pathway, b) environmental exposures such as smoking and arsenic, and c) the somatic markers: p53 expression and loss of heterozygosity (LOH) of chromosome 9q...
  39. Activation of the cyclin D1 promoter by arsenite
    MARK L STEINBERG; Fiscal Year: 2012
    ..If this can be demonstrated this finding will form the basis for future research. PUBLIC HEALTH RELEVANCE: Arsenic is a toxic environmental pollutant and carcinogen...
  40. Atherogenic Mechanisms of Arsenic
    Sanjay Srivastava; Fiscal Year: 2013
    ..provided by applicant): The overall goal of this project is to understand the mechanisms by which exposure to arsenic accelerates or aggravates atherosclerosis...
  41. Effects of Arsenic on Human Prostate Stem Cells and Prostate Cancer Risk
    Gail S Prins; Fiscal Year: 2013
    ..The overall goal of the proposed work is to determine whether developmental or adult exposures to inorganic arsenic (iAs) increase prostate cancer (PCa) risk by reprogramming human prostate stem cells...
  42. Cell survival and arsenic carcinogenesis
    Xianglin Shi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although the molecular mechanism of arsenic-induced carcinogenesis remains to be investigated, reactive oxygen species (ROS) generated by arsenic are considered to be important...
  43. Impact of infection and inflammation on the toxicity of environmental chemicals
    CHARLES KNUTSON; Fiscal Year: 2013
    ..inflammation and infection on the toxicity of environmental chemicals, this project will study two liver toxins: arsenic and aflatoxin B1...
  44. Skin Cancer and Arsenic Exposure
    Leslie K Dennis; Fiscal Year: 2013
    ..However, other environmental agents may also be important. Prior studies have reported associations between arsenic and non-melanoma skin cancers. Our recent study of CM cases and arsenic found an adjusted odds ratio of 2...
  45. The protective role of Nrf2 against arsenic-induced toxicity and carcinogenicity
    Donna D Zhang; Fiscal Year: 2013
    ..b>Arsenic (As) is a human carcinogen, which causes tumors in the skin, lung and bladder...
  46. Regulation on of the AIRAP/aip-1 pathway by metabolic stress
    Alfred L Fisher; Fiscal Year: 2013
    ..also induce the expression of AIRAP/aip-1 which is a recently described family of proteins that are induced by arsenic exposure and serve to augment the clearance of damaged proteins via the proteosome...
  47. Arsenic Contaminated Water Consumption &Spontaneous Pregnancy Loss in Romania
    Michael S Bloom; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Maternal exposure to concentrations of inorganic arsenic (iAs) in excess of 10 parts per billion (ppb) has been identified as a risk factor for clinically recognized spontaneous pregnancy loss in ..
  48. Arsenic Repression of GADD153 and Breast Cancer
    Keshav K Singh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arsenic is a well-known human carcinogen. Previous studies including human population studies provide an extensive and important link between the arsenic exposure and development of breast cancer...
  49. Jacksonville Racial and Ethnic Environmental Approaches to Community Health (REEA
    Cynthia M Harris; Fiscal Year: 2011
    ..that resulted in a myriad of health concerns for residents, particular concerns include contamination by lead, arsenic, polyaromatic hydrocarbons (PAHs) and dioxins...
  50. Microbiome-Based Risk Assessment: Reciprocal Effects of Arsenic on Environmental
    Stephanie Bachas-Daunert; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This proposed work investigates the reciprocal effects of arsenic ingestion upon both environmental and human health, as millions of people both in the U.S...
  51. Chemoprevention of arsenic-induced skin cancer
    Habibul Ahsan; Fiscal Year: 2013
    ..by applicant): Nearly 200 million people in the world including 40-70 million in Bangladesh have been exposed to arsenic from drinking water and thus at increased risk of skin and other cancers for their lifetime...
  52. The epigenetic link between environmental exposure and adult onset depression
    CHRISTINA RENE TYLER; Fiscal Year: 2013
    ..The research component of the training program seeks to determine the mechanism by which arsenic exposure during development increases susceptibility to depression in adulthood and the contribution of altered ..
  53. In vivo therapy and mechanisms of PAX8-PPARgamma thyroid cancer
    RONALD JAY KOENIG; Fiscal Year: 2013
    ..We also will test whether arsenic trioxide is therapeutic, especially in combination with Pio...
  54. Targeting PML for therapy in leukemia-initiating cells
    Keisuke Ito; Fiscal Year: 2013
    ..PML is also known to be pharmacologically inhibited by treatment of cells with arsenic, which specifically decreases the stability of the protein...
  55. Colloidal Quantum Dot/Well Near-Infrared NanoLabels
    Hua Mao; Fiscal Year: 2010
    ..in today's regulation environment in advanced countries, human body can tolerate a small amount of indium, arsenic and selenium...
  56. Novel systemic therapy to improve clinical outcome in small cell lung cancer
    Taofeek K Owonikoko; Fiscal Year: 2013
    ..first trial is a single institution study designed by he candidate that will evaluate the clinical efficacy of arsenic trioxide in relapsed disease...
  57. Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
    Susan A Korrick; Fiscal Year: 2010
    ..The metals to be studied are prenatal manganese (Mn), methylmercury (MeHg), arsenic (As), lead (Pb) and postnatal Pb exposure...
  58. Paradoxical roles of Nrf2 activation in arsenic-induced beta-cell dysfunction
    Jingbo Pi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant) There is growing evidence that chronic exposure of humans to inorganic arsenic, a potent environmental oxidative stressor, is associated with the incidence of Type 2 diabetes...
  59. Genetic Susceptibilty to Cardiovascular Effects of Arsenic Exposure
    Yu Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Genetic Susceptibility to Cardiovascular Effects of Arsenic Exposure Project summary cardiovascular disease (CVD) is the leading cause of death worldwide...
  60. Arsenic and T cell function: an Environment Maternal/child Immunity Study
    Kari C Nadeau; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arsenic (As) is a common environmental toxicant to which millions of people in the U.S. are exposed via contaminated drinking water...
  61. Epigenetic Effects of Prenatal Arsenic Exposure and Fetal Growth
    Molly L Kile; Fiscal Year: 2013
    ..prenatal metal exposure on perinatal and pediatric health outcomes to 1) examine the association between prenatal arsenic exposure, a common environmental pollutant, and fetal growth;2) investigate the interaction between arsenic and ..
  62. Does ArsenicMitigation in BangladeshRaiseExposure to Bacterial and ViralPathogens
    ALEXANDER FRANS VAN GEEN; Fiscal Year: 2010
    ..pumping groundwater from the 10 million existing tube wells in the country is exposed to toxic levels of arsenic (BGS/DPHE, 2001) and (2) diarrheal morbidity remains a severe problem for all age groups in rural Bangladesh...
  63. Mechanism of Arsenic-Induced Diabetes
    Miroslav Styblo; Fiscal Year: 2002
    ..Inorganic forms of arsenic (iAs) are highly toxic and are classified as human carcinogens...
  64. Optimized Hydride Generation Systems for Arsenic Specia*
    Miroslav Styblo; Fiscal Year: 2006
    ..Jiri Dedina as an extension of NIH Grant 1 R01 ES010845. The metabolism of inorganic arsenic (iAs) in humans involves reduction and methylation reactions that produce methylated trivalent and pentavalent ..
  65. Impact of Arsenicals on Selenoprotein Synthesis
    William Self; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Arsenic contamination of drinking water is a global health concern since exposure to arsenic has been linked with increased rates of cancer of skin, bladder, lung, liver and kidney...
  66. Arsenic Phytosensors
    Mark P Elless; Fiscal Year: 2010
    This Small Business Technology Transfer project seeks to develop a plant bioreporter for arsenic, a carcinogen that is widely dispersed in the environment and is one of the two most common contaminants at Superfund sites...
  67. Selenium against arsenic toxicity and skin lesions
    JULIAN SPALLHOLZ; Fiscal Year: 2005
    ..Phase III clinical intervention trial to assess the efficacy of dietary selenium supplements in reducing arsenic body load and in arresting the growth of cancer-associated skin lesions...
  68. A Continuous Monitor for Arsenic in Drinking Water
    William Dietze; Fiscal Year: 2004
    ..that is comparable to or better than most atomic spectroscopic detectors currently used for the determination of arsenic in waters. This instrument will also constantly monitor the concentration of arsenic in any fluid stream...
  69. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Arsenic is a natural contaminant of drinking water in many parts of the world, is a known human carcinogen and is #1 on the EPA list of hazardous chemicals...
  70. Engineering Enhanced Plants for Arsenic Remediation
    David Lee; Fiscal Year: 2009
    b>Arsenic is one of the most serious environmental contaminants in the United States. The traditional method for arsenic remediation involves excavating the contaminated soil and disposing it in hazardous waste landfills...
  71. Priming of liver disease by arsenic exposure
    Gavin E Arteel; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Inorganic arsenic is a natural drinking water contaminant and a known hepatotoxin...
  72. Metabolism and Toxicity of Arsenic in the Human Liver
    Miroslav Styblo; Fiscal Year: 2010
    b>Arsenic (As) is a potent environmental carcinogen. Tens of millions of people worldwide suffer of diseases caused by consumption of water with high levels of iAs...
  73. Arsenic Exposure and Skin Diseases in Bangladesh
    David Christiani; Fiscal Year: 2005
    b>Arsenic is a carcinogen, a Superfund toxic compound, and a common drinking-water contaminant...
  74. Mechanisms of Arsenic Toxicity in Vascular Development
    J Douglas Coffin; Fiscal Year: 2003
    DESCRIPTION (provided by applicant) Arsenic is a prevalent toxin in ground water and soil around areas with extractive industries...
  75. PROGRESSION OF HEPATIC NEOPLASIA BY PCB/ARSENIC MIXTURES
    JON PAINTER; Fiscal Year: 2004
    ..Polychlorinated biphenyis (PCBS) and arsenic are two common contaminants which can be found together in mixtures. PCBs are divided into two classes...