barium

Summary

Summary: An element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.

Top Publications

  1. pmc Potassium-selective block of barium permeation through single KcsA channels
    Kene N Piasta
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    J Gen Physiol 138:421-36. 2011
  2. ncbi Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel
    A E Lacerda
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
    Nature 352:527-30. 1991
  3. pmc A computational study of barium blockades in the KcsA potassium channel based on multi-ion potential of mean force calculations and free energy perturbation
    Christopher N Rowley
    Department of Chemistry, Memorial University of Newfoundland, St John s, NL A1B 3X9, Canada
    J Gen Physiol 142:451-63. 2013
  4. doi Patient acceptability of CT colonography compared with double contrast barium enema: results from a multicentre randomised controlled trial of symptomatic patients
    Christian von Wagner
    Department of Epidemiology and Public Health, University College London, London, UK
    Eur Radiol 21:2046-55. 2011
  5. ncbi Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels
    M De Leon
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 270:1502-6. 1995
  6. ncbi Coral record of increased sediment flux to the inner Great Barrier Reef since European settlement
    Malcolm McCulloch
    Research School of Earth Sciences, Australian National University, Canberra 0200, Australia
    Nature 421:727-30. 2003
  7. pmc Barium distributions in teeth reveal early-life dietary transitions in primates
    Christine Austin
    Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    Nature 498:216-9. 2013
  8. doi Selectivity in biomineralization of barium and strontium
    Minna R Krejci
    Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, IL 60208, USA
    J Struct Biol 176:192-202. 2011
  9. pmc Molecular determinant for specific Ca/Ba selectivity profiles of low and high threshold Ca2+ channels
    Thierry Cens
    Centre de Recherche de Biochimie Macromoleculaire, UMR 5237 Centre National de la Recherche Scientifique, 34293 Montpellier, France
    J Gen Physiol 130:415-25. 2007
  10. doi The effects of temperature and water concentration on the otolith incorporation of barium and manganese in black rockfish Sebastes melanops
    J A Miller
    Oregon State University, Department of Fisheries and Wildlife, Coastal Oregon Marine Experiment Station, Hatfield Marine Science Center, 2030 SE Marine Science Drive, Newport, Oregon 97365, USA
    J Fish Biol 75:39-60. 2009

Detail Information

Publications284 found, 100 shown here

  1. pmc Potassium-selective block of barium permeation through single KcsA channels
    Kene N Piasta
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    J Gen Physiol 138:421-36. 2011
    ..These results fit well with other kinetic measurements of selectivity as well as with the many crystal structures of KcsA in various ionic conditions...
  2. ncbi Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel
    A E Lacerda
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
    Nature 352:527-30. 1991
    ....
  3. pmc A computational study of barium blockades in the KcsA potassium channel based on multi-ion potential of mean force calculations and free energy perturbation
    Christopher N Rowley
    Department of Chemistry, Memorial University of Newfoundland, St John s, NL A1B 3X9, Canada
    J Gen Physiol 142:451-63. 2013
    ..A theoretical framework within classical rate theory is presented to incorporate the concentration dependence of the external ions on the lock-in effect...
  4. doi Patient acceptability of CT colonography compared with double contrast barium enema: results from a multicentre randomised controlled trial of symptomatic patients
    Christian von Wagner
    Department of Epidemiology and Public Health, University College London, London, UK
    Eur Radiol 21:2046-55. 2011
    To determine patient acceptability of barium enema (BE) or CT colonography (CTC).
  5. ncbi Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels
    M De Leon
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 270:1502-6. 1995
    ..Donation of the alpha 1C EF-hand region to the alpha 1E channel conferred the Ca(2+)-inactivating phenotype. These results strongly suggest that Ca2+ binding to the alpha 1C subunit initiates Ca2+ inactivation...
  6. ncbi Coral record of increased sediment flux to the inner Great Barrier Reef since European settlement
    Malcolm McCulloch
    Research School of Earth Sciences, Australian National University, Canberra 0200, Australia
    Nature 421:727-30. 2003
    ....
  7. pmc Barium distributions in teeth reveal early-life dietary transitions in primates
    Christine Austin
    Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    Nature 498:216-9. 2013
    ..Teeth from human children and captive macaques, with prospectively recorded diet histories, demonstrate that barium (Ba) distributions accurately reflect dietary transitions from the introduction of mother's milk through the ..
  8. doi Selectivity in biomineralization of barium and strontium
    Minna R Krejci
    Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, IL 60208, USA
    J Struct Biol 176:192-202. 2011
    ..of sulfate detected in the terminal vacuoles, we propose a "sulfate trap" model, where the presence of dissolved barium leads to preferential precipitation of (Ba,Sr)SO(4) due to its low solubility relative to SrSO(4) and CaSO(4)...
  9. pmc Molecular determinant for specific Ca/Ba selectivity profiles of low and high threshold Ca2+ channels
    Thierry Cens
    Centre de Recherche de Biochimie Macromoleculaire, UMR 5237 Centre National de la Recherche Scientifique, 34293 Montpellier, France
    J Gen Physiol 130:415-25. 2007
    ..These data therefore attribute to the DCS a unique role in the specific shaping of the Ca(2+) influx between the different HVA channels...
  10. doi The effects of temperature and water concentration on the otolith incorporation of barium and manganese in black rockfish Sebastes melanops
    J A Miller
    Oregon State University, Department of Fisheries and Wildlife, Coastal Oregon Marine Experiment Station, Hatfield Marine Science Center, 2030 SE Marine Science Drive, Newport, Oregon 97365, USA
    J Fish Biol 75:39-60. 2009
    ..Caution should be applied in the interpretation of geographic variation of [Mn:Ca](otolith) until the mechanisms regulating its incorporation are more fully understood...
  11. pmc Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currents
    Xianming Wang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Biophys J 89:1731-43. 2005
    ..In summary, the physicochemical properties of the amino acid residues at positions 1144 and 1152 are crucial to the pore's ability to distinguish between multiple Ba(2+) ions and Ca(2+) ions...
  12. ncbi Physical and biological properties of barium cross-linked alginate membranes
    Heiko Zimmermann
    Abteilung Kryobiophysik and Kryotechnologie, Fraunhofer Institut für Biomedizinische Technik, D 66386 St Ingbert, Germany
    Biomaterials 28:1327-45. 2007
    ..Murine L929 cells adhere strongly to the rough surface of crystal-bombarded membranes. NaCl-mediated membrane swelling can be prevented by partial replacement of salt with sorbitol allowing cell culture on the membranes...
  13. ncbi Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line
    A Scholze
    Institut fur Pharmakologie, Freie Universität Berlin 14195 Berlin, Germany
    Mol Endocrinol 15:1211-21. 2001
    ..3 calcium channel that is stimulated by G(i)/G(o)-coupled GPCRs and differs significantly in distinct biophysical characteristics from the cardiac subtype (CaV1.2a), suggesting that the channels have different roles in native cells...
  14. pmc Barium ions selectively activate BK channels via the Ca2+-bowl site
    Yu Zhou
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 109:11413-8. 2012
    ..6 for Ca(2+) to about ∼2.8 for Ba(2+). These results support the idea that ionic radius is an important determinant of selectivity differences among different divalent cations observed for each Ca(2+)-binding site...
  15. doi Selective and effective adsorption of methyl blue by barium phosphate nano-flake
    Fan Zhang
    Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China
    J Colloid Interface Sci 386:277-84. 2012
    We report the synthesis of barium phosphate (BP) nano-flake and its adsorption behavior to methyl blue (MB) in aqueous solution. The as-obtained BP nano-flake revealed pure rhombohedral crystal structure...
  16. pmc Colonoscopy can miss diverticula of the left colon identified by barium enema
    Ryota Niikura
    Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Shinjuku, Tokyo 162 8655, Japan
    World J Gastroenterol 19:2362-7. 2013
    To identify the diagnostic value of colonoscopy for diverticulosis as determined by barium enema.
  17. pmc Permeation and gating in CaV3.1 (alpha1G) T-type calcium channels effects of Ca2+, Ba2+, Mg2+, and Na+
    Nilofar Khan
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Gen Physiol 132:223-38. 2008
    ..Voltage strongly affects the concentration dependence of block, but not of permeation, for Ca(2+) or Ba(2+)...
  18. pmc External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites
    Gilad Gibor
    Department of Physiology and Pharmacology, Sackler Medical School, Tel Aviv University, Tel Aviv 69978, Israel
    J Gen Physiol 124:83-102. 2004
    ..Here we used external barium to investigate the permeation characteristics of homomeric KCNQ1 channels...
  19. ncbi Chronic barium intoxication disrupts sulphated proteoglycan synthesis: a hypothesis for the origins of multiple sclerosis
    Mark Purdey
    High Barn Farm, Elworthy, Taunton, Somerset TA43PX, UK
    Med Hypotheses 62:746-54. 2004
    High level contamination by natural and industrial sources of the alkali earth metal, barium (Ba) has been identified in the ecosystems/workplaces that are associated with high incidence clustering of multiple sclerosis (MS) and other ..
  20. pmc Effect of phosphatidylserine on unitary conductance and Ba2+ block of the BK Ca2+-activated K+ channel: re-examination of the surface charge hypothesis
    Jin Bong Park
    Department of Pharmacology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul national Universiyt, Suwon, Korea
    J Gen Physiol 121:375-97. 2003
    ....
  21. ncbi Gating of the expressed T-type Cav3.1 calcium channels is modulated by Ca2+
    L Lacinova
    Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia
    Acta Physiol (Oxf) 186:249-60. 2006
    ..We have investigated the influence of Ca2+ ions on the basic biophysical properties of T-type calcium channels...
  22. doi Simultaneous use of strontium:calcium and barium:calcium ratios in otoliths as markers of habitat: application to the European eel (Anguilla anguilla) in the Adour basin, South West France
    H Tabouret
    IFREMER Laboratoire des Ressources Halieutiques d Aquitaine, UFR côte Basque, 1 Allée du Parc Montaury, 64600 Anglet, France
    Mar Environ Res 70:35-45. 2010
    ....
  23. pmc Barium promotes anchorage-independent growth and invasion of human HaCaT keratinocytes via activation of c-SRC kinase
    Nguyen Dinh Thang
    Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai shi, Aichi, Japan
    PLoS ONE 6:e25636. 2011
    ..This study and previous studies showed high levels of barium as well as arsenic in the well water...
  24. doi Barium inhibits arsenic-mediated apoptotic cell death in human squamous cell carcinoma cells
    Ichiro Yajima
    Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences Building No 50, 11F, Chubu University, 1200 Matsumoto cho, Kasugai, Aichi 487 8501, Japan
    Arch Toxicol 86:961-73. 2012
    Our fieldwork showed more than 1 μM (145.1 μg/L) barium in about 3 μM (210...
  25. doi Screening of plant species for phytoremediation of uranium, thorium, barium, nickel, strontium and lead contaminated soils from a uranium mill tailings repository in South China
    Guang Yue Li
    Key Discipline Laboratory for National Defense for Biology Technology in Uranium Mining and Hydrometallurgy, University of South China, 421001 Hengyang, Hunan, People s Republic of China
    Bull Environ Contam Toxicol 86:646-52. 2011
    The concentrations of uranium, thorium, barium, nickel, strontium and lead in the samples of the tailings and plant species collected from a uranium mill tailings repository in South China were analyzed...
  26. doi Evidence for dietary change but not landscape use in South African early hominins
    Vincent Balter
    laboratoire de géologie de Lyon, UMR 5276, CNRS, Ecole Normale Superieure de Lyon, 15 parvis René Descartes BP 7000, 69342 Lyon Cedex 07, France
    Nature 489:558-60. 2012
    ..Laser ablation profiles of strontium/calcium, barium/calcium and strontium isotope ratios in tooth enamel are a means to decipher intra-individual diet and habitat ..
  27. ncbi Agreement of aspiration tests using barium videofluoroscopy, salivagram, and milk scan in children with cerebral palsy
    G Baikie
    Department of Child Development and Rehabilitation, Royal Children s Hospital, Parkville, Victoria, Australia 3052
    Dev Med Child Neurol 47:86-93. 2005
    To study the agreement between three tests for aspiration, barium videofluoroscopy, salivagram, and milk scan we studied 63 children with severe non-ambulant spastic quadriplegic cerebral palsy (CP) aged 14 months to 16 years (32 males, ..
  28. pmc Interactive effects of Al, Ca and other cations on root elongation of rice cultivars under low pH
    Toshihiro Watanabe
    Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kitaku, Sapporo 060 8589, Japan
    Ann Bot 95:379-85. 2005
    ..If displacement of Ca is an essential cause of Al toxicity in rice, Al toxicity may show the same trend as toxicities of elements such as Sr and Ba that are effective in displacing Ca...
  29. ncbi Separation of calcium channel current components in mouse chromaffin cells superfused with low- and high-barium solutions
    J M Hernandez-Guijo
    Instituto de Farmacología Teófilo Hernando y Departamento de Farmacología, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 4, E 28029 Madrid, Spain
    Pflugers Arch 436:75-82. 1998
    ....
  30. ncbi Voltage-dependent Ba2+ permeation through store-operated CRAC channels: implications for channel selectivity
    Daniel Bakowski
    Department of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Cell Calcium 42:333-9. 2007
    ....
  31. doi Role of barium esophagography in evaluating dysphagia
    Brian C Allen
    Imaging Institute, Hb6, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cleve Clin J Med 76:105-11. 2009
    ..We usually recommend that most patients with dysphagia initially undergo barium esophagography, and in this paper we discuss its role in evaluating dysphagia.
  32. ncbi Barium ions enter chromaffin cells via voltage-dependent calcium channels and induce secretion by a mechanism independent of calcium
    E Heldman
    Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892
    J Biol Chem 264:7914-20. 1989
    b>Barium ions enter chromaffin cells via voltage-sensitive calcium channels, although the intracellular site of barium action is distinct from that of calcium...
  33. pmc The actions of barium and strontium on exocytosis and endocytosis in the synaptic terminal of goldfish bipolar cells
    G Neves
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Physiol 535:809-24. 2001
    ..5. The recovery of the membrane capacitance was equally rapid in Sr2+ and Ca2+, demonstrating that the fast mode of endocytosis could be triggered by either cation...
  34. ncbi Acute self-poisoning by ingestion of cadmium and barium
    Yao Min Hung
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Taiwan
    Nephrol Dial Transplant 19:1308-9. 2004
  35. pmc Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block
    Franck C Chatelain
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 4:e7496. 2009
    ....
  36. pmc Efficacy of barium-based fecal tagging for CT colonography: a comparison between the use of high and low density barium suspensions in a Korean population - a preliminary study
    Min Ju Kim
    Department of Radiology and Research Institute of Radiology and Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Korean J Radiol 10:25-33. 2009
    This preliminarily study was designed to determine and to compare the efficacy of two commercially available barium-based fecal tagging agents for CT colonography (CTC) (high-density [40% w/v] and low-density [4...
  37. ncbi Transcript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunit
    Zhen Zhi Tang
    Department of Physiology, National University of Singapore, Singapore 117597
    J Biol Chem 279:44335-43. 2004
    ..This systematic portrait of splice variation furnishes a reference library for comprehending combinatorial arrangements of Cav1.2 splice exons, especially as they impact development, physiology, and disease...
  38. pmc Ethanol effects on dopaminergic ventral tegmental area neurons during block of Ih: involvement of barium-sensitive potassium currents
    John McDaid
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA
    J Neurophysiol 100:1202-10. 2008
    ..longer latency ethanol-induced inhibition was not observed in DA VTA neurons from mice or rats in the presence of barium (100 microM), which blocks G protein-linked potassium channels (GIRKs) and other inwardly rectifying potassium ..
  39. pmc Cav1.3 (alpha1D) Ca2+ currents in neonatal outer hair cells of mice
    Marcus Michna
    Institute of Physiology II and Department of Otolaryngology, Tuebingen Hearing Research Centre THRC, University of Tuebingen, Gmelinstrasse 5, D 72076 Tuebingen, Germany
    J Physiol 553:747-58. 2003
    ..Single cell RT-PCR revealed expression of Cav1.3 in OHCs. In OHCs from Cav1.3-/- mice, Ba2+ current density was reduced to 0.6 +/- 0.5 pA pF-1 (n = 9) indicating that > 97 % of the Ca2+ channel current in OHCs flows through Cav1.3...
  40. ncbi The mechanism of intrinsic amplification of hyperpolarizations and spontaneous bursting in striatal cholinergic interneurons
    Charles J Wilson
    Department of Biology, University of Texas at San Antonio, 6900 North Loop, 1604 West, San Antonio, Texas 78249, USA
    Neuron 45:575-85. 2005
    ....
  41. ncbi A family of gamma-like calcium channel subunits
    N Klugbauer
    Institut fur Pharmakologie und Toxikologie der Technischen Universitat Munchen, Biedersteiner Str 29, 80802, Munich, Germany
    FEBS Lett 470:189-97. 2000
    ..The coexpression of the gamma-5 subunit accelerates the time course of current activation and inactivation of the alpha(1G) T-type calcium channel...
  42. ncbi Barium and strontium leaching from aged glass particle/resin matrix dental composites
    Manshui Zhou
    Department of Chemistry M C 111, University of Illinois at Chicago, 4500 SES, 845 West Taylor Street, Chicago, IL 60607 7061, USA
    Dent Mater 21:145-55. 2005
    ..This study characterizes the loss of Ba and Sr from glass particle/resin-matrix dental composites during simulated aging...
  43. ncbi Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography
    Hiroshi Ohata
    Second Department of Internal Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Cancer Sci 96:713-20. 2005
    ..programs for use in Japan, we studied a new screening program that combines serum pepsinogen (PG) testing and barium digital radiography (DR)...
  44. doi Novel sulfated glucomannan-barium-alginate microcapsules in islet transplantation: significantly decreased the secretion of monocyte chemotactic protein 1 and improved the activity of islet in rats
    X Chen
    Second Affiliated Hospital, Harbin Medical University, Harbin, China
    Transplant Proc 41:4307-12. 2009
    ..In this study, novel sulfated glucomannan-barium-alginate (SGA) microcapsules were prepared to encapsulate islets with barium-alginate (ABa) and calcium alginate-..
  45. ncbi Calcified gastrointestinal stromal tumor of the sigmoid colon mimicking inspissated barium on CT
    Rich Rana
    University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    AJR Am J Roentgenol 187:W322-3. 2006
  46. ncbi Ethanol excitation of dopaminergic ventral tegmental area neurons is blocked by quinidine
    Sarah B Appel
    Department of Physiology and Biophysics M C 901, University of Illinois at Chicago, 835 S Wolcott Ave, Chicago, IL 60612 7342, USA
    J Pharmacol Exp Ther 306:437-46. 2003
    ..Ih with cesium (5 mM) or ZD7288 (30 microM), or by block of G-protein-coupled inwardly rectifying K+ channels with barium (500 microM)...
  47. pmc The plasma membrane calcium ATPase (PMCA) of neurones is electroneutral and exchanges 2 H+ for each Ca2+ or Ba2+ ion extruded
    Roger C Thomas
    Physiological Laboratory, University of Cambridge, Downing Site, Cambridge, UK
    J Physiol 587:315-27. 2009
    ....
  48. pmc The anomalous mole fraction effect in calcium channels: a measure of preferential selectivity
    Dirk Gillespie
    Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois, USA
    Biophys J 95:2658-72. 2008
    ..The resistors-in-series model provides a fundamentally different explanation of the AMFE than the traditional theory and does not require single filing, multiple occupancy, or momentum-correlated ion motion...
  49. ncbi Preparation and characterization of carbonated barium-calcium hydroxyapatite solid solutions
    Akemi Yasukawa
    School of Chemistry, Osaka University of Education, 4 698 1 Asahigaoka, Kashiwara shi, Osaka 582 8582, Japan
    J Colloid Interface Sci 288:468-74. 2005
    Particles of carbonated barium-calcium hydroxyapatite solid solutions (BaCaHap) with different Ba/(Ba+Ca) (X(Ba)) atomic ratios were prepared by a wet method at 100 degrees C and characterized by various means...
  50. ncbi Contribution of the IsK (MinK) potassium channel subunit to regulatory volume decrease in murine tracheal epithelial cells
    H Lock
    Cell Signalling Unit, Department of Experimental Sciences, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    J Biol Chem 275:34849-52. 2000
    ..These data suggest that the IsK potassium subunit plays an important role in RVD in murine tracheal epithelial cells...
  51. ncbi Activation of barium-sensitive inward rectifier potassium channels mediates remote dilation of coronary arterioles
    R J Rivers
    Departments of Anesthesiology and Pharmacology Physiology, University of Rochester, Rochester, NY, USA
    Circulation 104:1749-53. 2001
    ....
  52. pmc Block of CaV1.2 channels by Gd3+ reveals preopening transitions in the selectivity filter
    Olga Babich
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    J Gen Physiol 129:461-75. 2007
    ..Therefore, we propose that at submicromolar concentrations, Gd(3+) binds at the entry to the selectivity locus and that the affinity of the site for permeant ions decreases during preopening transitions of the channel...
  53. ncbi Molecular properties of Kcv, a virus encoded K+ channel
    Cinzia Pagliuca
    Dipartimento di Biologia e IBF CNR, Universita degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
    Biochemistry 46:1079-90. 2007
    ..We conclude that specific binding interactions of cations in the conductive pathway are an important determinant of channel stability and function...
  54. ncbi Nerve growth factor increases insulin secretion and barium current in pancreatic beta-cells
    T Rosenbaum
    Department of Biophysics, , , Circuito Exterior, Ciudad Universitaria, Mexico City, Mexico
    Diabetes 50:1755-62. 2001
    We analyzed the effect of a brief exposure to nerve growth factor (NGF) on insulin secretion and macroscopic barium currents of single adult rat pancreatic beta-cells. After a 1-h exposure to NGF (50 ng/ml), single beta-cells show a 2...
  55. ncbi A conserved glutamate is important for slow inactivation in K+ channels
    H P Larsson
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuron 27:573-83. 2000
    ..Breaking these bonds allows the P-S6 loop to rotate, which closes the slow inactivation gate. Our results also suggest a mechanism of how the movement of the voltage sensor can induce slow inactivation by destabilizing these bonds...
  56. pmc Chlorella virus ATCV-1 encodes a functional potassium channel of 82 amino acids
    Sabrina Gazzarrini
    Department of Biology and CNR Istituto di Biofisica, Universita degli Studi di Milano, Italy
    Biochem J 420:295-303. 2009
    ..K+ channels: it assembles into a tetramer, is K+ selective and is inhibited by the canonical K+ channel blockers, barium and caesium...
  57. pmc Localization of divalent cation-binding site in the pore of a small conductance Ca(2+)-activated K(+) channel and its role in determining current-voltage relationship
    Heun Soh
    Department of Life Science, Kwangju Institute of Science and Technology K JIST, 1 Oryong dong, Buk Gu, Gwangju 500 712, Korea
    Biophys J 83:2528-38. 2002
    ..Because the Ser residue unique for the subfamily of SK(Ca) channels is likely to locate closely to the selectivity filter of the channels, it may also contribute to other permeation characteristics of SK(Ca) channels...
  58. ncbi Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery
    Tom Karkanis
    Department of Physiology and Pharmacology, University of Western Ontario, London, Canada N6A 5C1
    Am J Physiol Heart Circ Physiol 284:H2325-34. 2003
    ..Ba(2+) inhibited [(3)H]thymidine incorporation, indicating a possible role for K(IR) channels in the regulation of proliferation. The phenotype-dependent plasticity of K(IR) channels may have relevance to vascular remodeling...
  59. pmc Patch-clamp analysis in canine cardiac Purkinje cells of a novel sodium component in the pacemaker range
    Marcello Rota
    Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Box 31, Brooklyn, NY 11203, USA
    J Physiol 548:147-65. 2003
    ....
  60. pmc Ni2+ block of CaV3.1 (alpha1G) T-type calcium channels
    Carlos A Obejero-Paz
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Gen Physiol 132:239-50. 2008
    ..1, inhibition of Ca(V)3.2 by Ni(2+) was essentially independent of voltage, and was similar in 2 mM Ca(2+) vs. Ba(2+), consistent with inhibition by a different mechanism, at a site outside the pore...
  61. ncbi Phenotypic and behavioral defects caused by barium exposure in nematode Caenorhabditis elegans
    D Y Wang
    Department of Genetics and Developmental Biology, Southeast University, Nanjing, 210009, China
    Arch Environ Contam Toxicol 54:447-53. 2008
    To examine the possible phenotypic defects from barium exposure, a model organism, Caenorhabditis elegans, was chosen to analyze the multiple toxicities in barium-exposed animals...
  62. pmc Biophysical and pharmacological characterization of voltage-gated calcium currents in turtle auditory hair cells
    M E Schnee
    Neuroscience Center and Kresge Hearing Laboratories, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Physiol 549:697-717. 2003
    ..A bell-shaped voltage dependence and modest sensitivities to intracellular calcium chelators and external barium ions suggest that inactivation was calcium dependent.
  63. ncbi Acute barium intoxication and hemodiafiltration
    Marc Koch
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    J Toxicol Clin Toxicol 41:363-7. 2003
    ..following a suicide attempt associating the calcium channel blocker amlodipine, the antidepressant fluoxetine and barium carbonate...
  64. pmc Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues
    N Alagem
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Physiol 534:381-93. 2001
    ..1(E125N) mutant. 4. These results thus reveal two unique roles for the amino acids at positions 125 and 141 in aiding the interaction of Ba(2+) with the channel. Their possible roles in K+ permeation are discussed...
  65. ncbi Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter
    T Lu
    Department of Biological Sciences, 915 Fairchild Center, MC2462, Columbia University, New York, New York 10027, USA
    Nat Neurosci 4:239-46. 2001
    ....
  66. pmc Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytes
    G X Liu
    Institut fur Normale und Pathologische Physiologie, Marburg University Deutschhausstrasse 2, D 35037 Marburg, Germany
    J Physiol 532:115-26. 2001
    ..0 pS) correspond to gpKir2.2. The intermediate-conductance (23.8 pS) and low-conductance (10.7 pS) channels described here may correspond to gpKir2.1 and gpKir2.3, respectively...
  67. ncbi Mechanisms underlying regulation of a barium-sensitive K+ conductance by ATP in single proximal tubule cells isolated from frog kidney
    L Robson
    Department of Biomedical Science, Alfred Denny Building, University of Sheffield, Sheffield S10 2TN, UK
    J Membr Biol 204:39-47. 2005
    ..Previous experiments have identified a barium-sensitive K(+) conductance (G(Ba)) in proximal tubule cells isolated from frog kidneys...
  68. pmc Inwardly rectifying current-voltage relationship of small-conductance Ca2+-activated K+ channels rendered by intracellular divalent cation blockade
    H Soh
    Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500-712, Korea
    Biophys J 80:2207-15. 2001
    ....
  69. pmc The pore helix dipole has a minor role in inward rectifier channel function
    Franck C Chatelain
    Cardiovascular Research Institute, Department of Biochemistry and Biophysics, California Institute for Quantitative Biomedical Research, University of California, San Francisco, Box 2532, San Francisco, California 94143, USA
    Neuron 47:833-43. 2005
    ..Here, using genetic selections to probe interactions of an exemplar potassium channel blocker, barium, with the inward rectifier Kir2...
  70. ncbi C-terminal fragments of the alpha 1C (CaV1.2) subunit associate with and regulate L-type calcium channels containing C-terminal-truncated alpha 1C subunits
    T Gao
    Department of Molecular Pharmacology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 276:21089-97. 2001
    ..The results support the hypothesis the C- terminal fragments of the alpha(1C) subunit can associate with C-terminal-truncated alpha(1C) subunits and inhibit the currents through L-type Ca(2+) channels...
  71. ncbi Uncertainty of inductively coupled plasma mass spectrometry based measurements: an application to the analysis of urinary barium, cesium, antimony and tungsten
    A Alimonti
    Department of Environment and Primary Prevention, Italian National Institute of Health, Rome, Italy
    Rapid Commun Mass Spectrom 19:3131-8. 2005
    The wide use of barium (Ba), cesium (Cs), antimony (Sb) and tungsten (W) in many industrial and agricultural fields causes the increased release of these metals into the environment, laying the basis for health risk...
  72. ncbi Ni2+ slows the activation kinetics of high-voltage-activated Ca2+ currents in cortical neurons: evidence for a mechanism of action independent of channel-pore block
    J Magistretti
    Dipartimento di Neurofisiologia Sperimentale, Istituto Nazionale Neurologico Carlo Besta, Milano, Italy
    J Membr Biol 179:243-62. 2001
    ....
  73. ncbi Poisoning as a result of barium styphnate explosion
    Ira A Jacobs
    Department of Surgery, Morristown Memorial Hospital, Morristown, New Jersey, USA
    Am J Ind Med 41:285-8. 2002
    Acute barium poisoning is most often the result of accidental or suicidal ingestion of the rodenticide, barium carbonate...
  74. pmc External barium influences the gating charge movement of Shaker potassium channels
    R S Hurst
    Department of Anesthesiology, University of California at Los Angeles 90095, USA
    Biophys J 72:77-84. 1997
    ..The results suggest that Ba2+ binds to a specific site on the Shaker K+ channel that destabilizes the open conformation and thus facilitates the return of gating charge upon repolarization...
  75. ncbi Barium reduces resting blood flow and inhibits potassium-induced vasodilation in the human forearm
    Matthew Dawes
    Department of Clinical Pharmacology and Centre for Cardiovascular Biology and Medicine, King s College, London, UK
    Circulation 105:1323-8. 2002
    ..The role (if any) of K(IR) in controlling human resistance vessel tone is unknown, and we investigated this in the forearm...
  76. ncbi Elevated silver, barium and strontium in antlers, vegetation and soils sourced from CWD cluster areas: do Ag/Ba/Sr piezoelectric crystals represent the transmissible pathogenic agent in TSEs?
    Mark Purdey
    High Barn Farm, Elworthy, Taunton, Somerset TA4 3PX, UK
    Med Hypotheses 63:211-25. 2004
    High levels of Silver (Ag), Barium (Ba) and Strontium (Sr) and low levels of copper (Cu) have been measured in the antlers, soils and pastures of the deer that are thriving in the chronic wasting disease (CWD) cluster zones in North ..
  77. pmc A Ba2+ chelator suppresses long shut events in fully activated high-conductance Ca(2+)-dependent K+ channels
    J Neyton
    Laboratoire de Neurobiologie, Ecole Normale Superieure, CNRS URA 1857, Paris, France
    Biophys J 71:220-6. 1996
    ..This was confirmed by showing that a crown-ether compound that strongly chelates Ba2+ completely suppresses the long shut events when added to the inner compartment...
  78. ncbi Cloning of the beta(2a) subunit of the voltage-dependent calcium channel from human heart: cooperative effect of alpha(2)/delta and beta(2a) on the membrane expression of the alpha(1C) subunit
    H Yamaguchi
    Institute of Molecular Pharmacology, Department of Cell Biology, University of Cincinnati, College of Medicine, 231 Bethesda Avenue, Cincinnati, Ohio, 45267 0828, USA
    Biochem Biophys Res Commun 267:156-63. 2000
    ....
  79. pmc The ligand-sensitive gate of a potassium channel lies close to the selectivity filter
    Peter Proks
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    EMBO Rep 4:70-5. 2003
    ..This is in marked contrast to the voltage-dependent gate of K(V) channels, which is located at the intracellular mouth of the pore...
  80. ncbi Sterilization of barium for vertebroplasty: an effective, reliable, and inexpensive method to sterilize powders for surgical procedures
    Robert A Leibold
    Colorado Imaging Associates, 8380 N Zuni St, Ste 100, Denver, CO 80110, USA
    AJR Am J Roentgenol 179:198-200. 2002
  81. ncbi Barium chromate is cytotoxic and genotoxic to human lung cells
    Sandra S Wise
    Center for Integrated and Applied Environmental Toxicology, Wise Laboratory of Environmental and Genetic Toxicology, Bioscience Research Institute, University of Southern Maine, Portland, Maine 04104 9300, USA
    Environ Mol Mutagen 42:274-8. 2003
    ..Accordingly, we investigated the cytotoxicity and clastogenicity of barium chromate (BC) in a human lung cell culture model (WTHBF-6 cells)...
  82. ncbi Effects of the potassium channel blocker barium on sodium and potassium transport in the rat loop of Henle in vivo
    S J Walter
    Division of Biomedical Sciences, Imperial College School of Medicine, London SW7 2AZ, UK
    Exp Physiol 86:469-74. 2001
    ..in vivo by perfusing superficial loops of Henle in anaesthetised rats with and without the K(+) channel blocker barium. Using a standard perfusate, intraluminal barium (5 mmol l(-1)) reduced sodium reabsorption (J(Na)) from 1887 +/- ..
  83. ncbi Mechanisms of adrenergic control of sino-atrial node discharge
    Hengtao Zhang
    Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
    J Biomed Sci 10:179-92. 2003
    ..NE INITIATES spontaneous discharge by inducing voltage oscillations unrelated to I(f)...
  84. ncbi Effects of barium, furosemide, ouabaine and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy
    Regina Jauch
    Johannes Müller Institut für Physiologie, Humboldt Universitat, Berlin, Germany
    Brain Res 925:18-27. 2002
    ..the relative contribution of these mechanisms has not yet been determined, we studied the effects of bath-applied barium (2 mM), ouabaine (9 microM), furosemide (2 mM), and DIDS (1 mM) on ionophoretically-induced rises in [K(+)](o) in ..
  85. ncbi Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents
    Gernot Schram
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 59:328-38. 2003
    ..Kir2 subunits are believed to underlie the cardiac inwardly rectifying current I(K1). The subunit composition of native I(K1) currents is uncertain, and it has been suggested that heteromultimer formation may play a role...
  86. ncbi Glutamate 172, essential for modulation of L247T alpha7 ACh receptors by Ca2+, lines the extracellular vestibule
    Donnie Eddins
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Cell Physiol 283:C1454-60. 2002
    ..The observations that E172 was essential for divalent cation modulation of L247T alpha7 nAChRs and was accessible to permeating ions suggest that this residue participates in coupling ion permeation with modulation of receptor activity...
  87. ncbi Role of the outer beta-sheet in divalent cation modulation of alpha7 nicotinic receptors
    James T McLaughlin
    Department of Pharmacology, CB 7365, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
    Mol Pharmacol 70:16-22. 2006
    ..In this setting, divalent cations, acting at the conserved glutamate in loop 9, act as full agonists or requisite coagonists...
  88. doi Feasibility of video capsule endoscopy in the management of children with Peutz-Jeghers syndrome: a blinded comparison with barium enterography for the detection of small bowel polyps
    Aymer Postgate
    Wolfson Unit for Endoscopy, St Mark s Hospital, and Department of Specialist Radiology, University College Hospital, London, UK
    J Pediatr Gastroenterol Nutr 49:417-23. 2009
    ..Prophylactic polypectomy may reduce subsequent complications. Traditional barium enterography (BE) has poor sensitivity and requires significant radiation...
  89. ncbi Contamination by arsenic and other trace elements in tube-well water and its risk assessment to humans in Hanoi, Vietnam
    Tetsuro Agusa
    Center for Marine Environmental Studies, CMES, Ehime University, Matsuyama 790 8577, Japan
    Environ Pollut 139:95-106. 2006
    ..To our knowledge, this study revealed for the first time that the residents are exposed not only to As but also Mn and Ba from groundwater in the Red River Delta, Vietnam...
  90. pmc Ca2+-dependent inactivation of CaV1.2 channels prevents Gd3+ block: does Ca2+ block the pore of inactivated channels?
    Olga Babich
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    J Gen Physiol 129:477-83. 2007
    ..A minimal model, in which the inactivation "gate" is an increase in affinity of the selectivity filter for permeating ions, successfully simulates the characteristic U-shaped voltage dependence of inactivation in Ca(2+)...
  91. ncbi Barium: rationale for a new oral reference dose
    C E Dallas
    Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, USA
    J Toxicol Environ Health B Crit Rev 4:395-429. 2001
    ..66 mg Ba/kg/d or 0.6 mg Ba/kg/d, respectively. It is proposed to use the more conservative value of 0.6 mg Ba/kg/d. This reassessment results in nearly an order of magnitude increase in the U.S. EPA oral RfD for Ba...
  92. doi Dysphagia dietary guidelines and the rheology of nutritional feeds and barium test feeds
    Lindsay Strowd
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Chest 133:1397-401. 2008
    ..Dysphagia is diagnosed by assessing the ability to swallow barium test feeds (BTF) of different viscosities...
  93. ncbi The vicissitudes of the pacemaker current I (Kdd) of cardiac purkinje fibers
    Mario Vassalle
    Department of Physiology and Pharmacology, Box 31 State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Biomed Sci 14:699-716. 2007
    ..It is concluded that the large body of evidence reviewed proves the pacemaker role of I (Kdd) (but not of I (f)) in Purkinje fibers...
  94. ncbi The mechanism of Ba(2+)-induced exocytosis from single chromaffin cells
    L von Rüden
    Max Planck Institut fur biophysikalische Chemie, Gottingen Nikolausberg, Germany
    FEBS Lett 336:48-52. 1993
    ..In some cases, Ba2+ additionally induces release of Ca2+ from internal stores, as evidenced by its effect on fura-2 fluorescence at different wavelengths...
  95. pmc The beta1a subunit regulates the functional properties of adult frog and mouse L-type Ca2+ channels of skeletal muscle
    Ruben Garcia
    Department of Pharmacology, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico DF 07360, Mexico
    J Physiol 545:407-19. 2002
    ..8 +/- 3.5 nC microF(-1), V = -54.5 +/- 2.2 mV and k = 16.4 +/- 1.3 mV (n = 21). Overall, the work describes a novel preparation to explore in situ the role of the beta(1a) subunit on the function of adult Ca(V)1.1 channels...
  96. ncbi Molecular determinants of voltage-dependent slow inactivation of the Ca2+ channel
    Chengzhang Shi
    NIA, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Biol Chem 277:6813-21. 2002
    ..No voltage-dependent characteristics were significantly changed, consistent with the C-type inactivation model suggesting constriction of the pore as the main mechanism possibly targeted by Ca(2+) sensors of inactivation...
  97. pmc Barium inhibition of the collapse of the Shaker K(+) conductance in zero K(+)
    F Gomez-Lagunas
    Departamento de Reconocimiento Molecular y Biologia Estructural, Instituto de Biotecnologia, UNAM, Cuernavaca, Morelos 62250, Mexico
    Biophys J 77:2988-98. 1999
    ..Ba(2+) is an effective K(+) substitute, inhibiting the passage of the channels into the stable nonconducting (noninactivated) mode of gating...
  98. pmc Effects of barium, lanthanum and gadolinium on endogenous chloride and potassium currents in Xenopus oocytes
    T Tokimasa
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    J Physiol 496:677-86. 1996
    ..Zinc, cadmium, cobalt and nickel were less potent than lanthanum, and gadolinium, manganese, barium and strontium had no effect at a concentration of 100 microM. 3...
  99. ncbi Potassium conductances in isolated single cells from Xenopus laevis colonic epithelium
    B Heinke
    , , Germany
    J Comp Physiol B 169:148-56. 1999
    ..b>Barium and cesium showed pronounced voltage-dependent blockage, with interaction at about 35% inside the pores...
  100. ncbi Ca2+-sensitive regulation of E-type Ca2+ channel activity depends on an arginine-rich region in the cytosolic II-III loop
    Jérôme Leroy
    Institute of Neurophysiology, Institute of Vegetative Physiology, University of Cologne, Robert Koch Strasse 39, D 50931 Köln, Germany
    Eur J Neurosci 18:841-55. 2003
    ..As a positive feedback-regulation of channel activity this novel activation mechanism might determine specific biological functions of E-type Ca2+ channels...
  101. doi Temperature dependence of Cav1.4 calcium channel gating
    J B Peloquin
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, HMRB 172b, 3330 Hospital Drive Northwest, University of Calgary, Calgary, Alberta, Canada T2N4N1
    Neuroscience 151:1066-83. 2008
    ..4 channels observed at near physiological temperatures the window current is preserved and could allow for tonic glutamate release from photoreceptors in the retina during dark adapted conditions...

Research Grants71

  1. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..flexible sigmoidoscopy (16), CT colonography (virtual colonoscopy) (17), capsule endoscopy (18), double contrast barium enema (19), molecular DNA tests in stool and blood (20-25);however, none is optimal, and with poor rates in some ..
  2. Homocysteine and Angiotensin II in Renovascular Remodeling
    Utpal Sen; Fiscal Year: 2013
    ..Plasma Hcy will be measured by HPLC. Vascular density will be measured by in vivo soft-tissue Barium sulfate-contrast X-ray angiography and renal cortical blood flow by moorFLPI full-filled laser perfusion imager...
  3. Environmental exposure to metal mixtures and kidney disease
    Mary Fox; Fiscal Year: 2009
    ..We will examine metal mixture exposures in a representative sample of the US population. The metals are barium, cadmium, cobalt, lead, mercury, molybdenum, and uranium...
  4. Regulation of pacemaking and bursting of substantia nigra dopamine neurons by cal
    CYNTHIA N KIMM; Fiscal Year: 2013
    ..types of calcium channels contributing to the total calcium current in these cells, but these studies used barium as a charge carrier instead of calcium and were performed at room rather than body temperature (Cardozo and Bean, ..
  5. Effects of Bolus Accommodation on Swallowing Effort in Healthy Elderly Individual
    Lisa A Lagorio; Fiscal Year: 2011
    ..Boluses include 5 and 10 ml of thin, nectar, and pudding barium, and 5 and 10 ml equivalent volumes of fresh banana impregnated with barium;each material will be swallowed twice...
  6. Diagnosis of Osteochondrosis using high field MRI
    CATHY SUE CARLSON; Fiscal Year: 2013
    ..cartilage canal blood vessels and validate these in cleared specimens in which the vessels have been perfused with barium sulfate. This career development award will allow Dr...
  7. Adherence to Swallowing Rehabilitation Exercises in Head and Neck Cancer
    Eileen H Shinn; Fiscal Year: 2013
    ..of the PREPARE intervention on anatomic swallowing function as assessed by gold-standard radiographic Modified Barium Swallow (MBS), which is scored with the OPSE...
  8. Strategies for the Treatment of Dysphagia in Patients with Alzheimer's Disease
    Jerilyn A Logemann; Fiscal Year: 2013
    ..determine whether selected measures of oropharyngeal swallow function from videofluoroscopy (VFG) and the modified barium swallow (MBS), will improve significantly while swallowing selected 3 and 10 ml thin liquid as compared to the ..
  9. Impact of Pulse Rate on Swallowing Impairment Assessment and Radiation Exposure
    Heather Shaw Bonilha; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Modified Barium Swallow Studies (MBSSs) are the key diagnostic test to identify abnormalities in the structures and functions of swallowing...
  10. Preclinical assay development of a novel Colon Cancer Marker (CCSA-4)
    JACK CLEMENS; Fiscal Year: 2007
    ..for detection of colon cancer, including fecal occult blood testing, flexible sigmoidoscopy, double contrast barium enema and colonoscopy...
  11. Multi-Ion, Free Energy Study of Effect of Ba2+ Blockage on KcsA Ion Selectivity
    KAREN MICHELLE CALLAHAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of the proposed research is to elucidate the mechanism of barium blockade of the selectivity filter of potassium channels and to determine the effects of barium blockade upon ion selectivity ..
  12. PROSPECTIVE COMPARISON OF COLONIC IMAGING TEST
    Don Rockey; Fiscal Year: 2001
    ..The most common tests used to image the colon include air contrast barium enema and colonoscopy, each of which is associated with its own sets of benefits and limitations...
  13. AM-241 APPLICATORS FOR INTRACAVITARY IRRADIATION
    Ravinder Nath; Fiscal Year: 1990
    ..HVL in 1/8th of lead) placed on the applicator or inside some body cavities (for example, hypaque in bladder, barium sulphate in rectum)...
  14. Psychophysics of Divalent Salts and Metallic Taste
    HARRY LAWLESS; Fiscal Year: 2006
    ..table including calcium, an active participant in various steps of taste transduction, as well as magnesium and barium. In preliminary research with calcium and magnesium, a frequent taste descriptor was the term "metallic...
  15. FROM CARDIAC MUSCLE TO VENTRICLE
    William Hunter; Fiscal Year: 1999
    ..Studies will utilize myocardium in a state of sustained systole (barium contracture)...
  16. Increasing Colon Cancer Screening in Primary Care
    Ronald Myers; Fiscal Year: 2004
    ..Alternative CRC screening regimens that are recommended include having a barium enema X-ray (BE) at five- year intervals or a colonoscopy (CX) every 10 years...
  17. AUTOMATIC COLON SEGMENTATION FOR 3D VIRTUAL COLONOSCOPY
    JEROME LIANG; Fiscal Year: 1999
    ..An appropriate amount of barium mixed in meals will be given to the patients prior to the CT scans...
  18. Optical Ceramic Hafnates: New Fast PET Scintillator
    Charles Brecher; Fiscal Year: 2006
    We propose to conduct research and development of a new ceramic scintillator based on cerium-activated barium hamate (BaHfO3:-Ce), strontium hafnate (SrHfO3:-Ce), and lutetium hafnate (Lu2Hf2O7:Ce)...
  19. Increasing CRC Screening in Health Plan Members
    Karen Glanz; Fiscal Year: 2007
    ..50 periodically obtain screening by one of several modalities (FOBT, sigmoidoscopy,colonoscopy,or double contrast barium enema). However, CRC screening remains substantially underutilized in the U.S...
  20. Colorectoral cancer screening decisions in primary care
    James Dolan; Fiscal Year: 2006
    ..every 5 years, combined annual fecal occult blood tests and flexible sigmoidoscopy every 5 years, double contrast barium enema every 5 years, and colonoscopy every 10 years...
  21. OPTIMIZATION OF SMALL PARTICLE COMPOSITES
    TRITALA VAIDYANATHAN; Fiscal Year: 1991
    ..A 4x5x5 factorial design will be used for the layout. Four filler compositions to be studied are Barium borosilicate; strontium borosilicate; Borosilicate and quartz...
  22. ENHANCING DIAGNOSTIC EVALUATION IN COLORECTAL CANCER
    Ronald Myers; Fiscal Year: 1999
    ..Experts consider CDE as either colonoscopy or double air-contrast barium enema x-ray (BE) with flexible sigmoidoscopy...
  23. LOW COST, HIGH PERFORMANCE HTS MAGNETS FOR NMR
    Michael Strauss; Fiscal Year: 2000
    ..are brittle ceramic materials (BSCCO is bismuth, strontium, calcium, copper oxide and YBCO is yttrium, barium, copper oxide). In metal processing, a malleable wire is wound into a coil magnet...
  24. NEUROMUSCULAR ACTIVITY OF THE PHARYNX DURING SWALLOWING
    Jeffrey Palmer; Fiscal Year: 1991
    ..marker technique demonstrates large cephalocaudal displacements which were not appreciated with traditional barium swallow videoradiography...
  25. CONTROL OF LARGE BOWEL CANCER FOLLOWING POLYPECTOMY
    Sidney Winawer; Fiscal Year: 1991
    ..annual questionnaire and fecal occult blood test, and at 6 years with a complete colonoscopy and double contrast barium enema; and implementation of a validated family history questionnaire...
  26. SCINTIGRAPHIC QUANTIFICATION OF PULMONARY ASPIRATION
    Kenneth Silver; Fiscal Year: 1992
    ..Available tools for detecting airway aspiration, specifically barium fluoroscopy, are insufficient for detailing the fate of food aspirated through the glottis...
  27. Nanoplatelet Reinforced Smectic Glasses For Dental Restorants
    STEPHEN WELLINGHOFF; Fiscal Year: 2009
    ..Of special interest are compositions of high radio-opacity and low cost, such as ZrO2 and barium substituted oxides...
  28. DRUG EFFECTS ON IMPULSE INITIATION IN THE HEART
    KENNETH DANGMAN; Fiscal Year: 1991
    ..automaticity (which occurs from maximum diastolic potentials of -61 to -70 mV) and low potential automaticity in barium- or cesium- pretreated Purkinje fibers...
  29. Subconductance behavior in T-type calcium channels
    KATIE BITTNER; Fiscal Year: 2009
    ..and kinetics of each conductance state will be measured in both the presence of different permeant cations, Ca, barium, and monovalent cations. In the second aim quantitative differences between CaV 3.1 and CaV 3.2 will be assessed...
  30. NATIONAL COLLABORATIVE DIAGNOSTIC IMAGING TRIAL PROJECTS
    Elias Zerhouni; Fiscal Year: 1992
    ..The accuracy of gastrointestinal barium studies, CT, MRI, ultrasonography and angiography will be evaluated in their ability to stage the loco-regional ..
  31. IMPLANTABLE STIMULATOR FOR PREVENTING ASPIRATION
    DUSTIN TYLER; Fiscal Year: 1999
    ..measurements of flexible fiberoptic laryngoscope visualization, methylene blue swallow tests, and modified barium swallow tests will be used to study RLN stimulation-induced VCA for preventing aspiration...
  32. VIDEOFLUOROSCOPY OF PRETERM INFANT SWALLOWING
    Eugene Goldfield; Fiscal Year: 2007
    ..The study hypotheses are tested by experimental manipulation of barium sulfate viscosity during infant swallowing, kinematic analysis of recorded swallow images, and non-radiologic ..
  33. FLUOROSCOPIC DOSE REDUCTION USING IRIS CONTROL
    Stephen Rudin; Fiscal Year: 1980
    ..The study will emphasize the double contrast barium enema procedure where high quality images are not always necessary because almost all of the fluoroscopic patient ..
  34. PROPERTIES OF THE INWARD RECTIFIER OF SKELETAL MUSCLE
    PAUL HOROWICZ; Fiscal Year: 1980
    ..The modifications produced by various agents blocking this potassium conductance system (i.e., Barium, quaternary ammonium ions, aminopyridines) will be also studied...
  35. IMPLEMENTATION OF HIGH SPEED RARE EARTH SCREENS
    FRANK PURNELL; Fiscal Year: 1980
    ..e., chest films, bone films, barium studies, IVPs, etc.)...
  36. A randomized trial of NMES vs. traditional dysphagia therapy after stroke
    Giselle Mann; Fiscal Year: 2009
    ..Following randomization, all subjects will undergo a video-x-ray (modified barium swallow) of swallowing to confirm the presence of oropharyngeal dysphagia and provide objective data about the ..
  37. SOLID-STATE LASER SOURCE FOR CORNEAL ABLATION
    PETER MOULTON; Fiscal Year: 1991
    ..of a pulsed Ti:Sapphire laser will be converted to the 205-225 nm region via frequency quadrupling in two beta-barium borate crystals...
  38. X-ray Filter for In Vivo Contrast-Enhanced Imaging
    RICHARD HARMS; Fiscal Year: 2004
    ..dose, high spatial resolution, 2-D and 3-D images in vivo of molecular probes or tracers containing iodine, barium, or xenon...
  39. Glial Maintenance of Local K+ and Neurotransmission
    JULIAN MEEKS; Fiscal Year: 2005
    ..Astrocyte patch-clamp recordings will determine the physiological properties of barium-sensitive stimulus evoked K+ currents...
  40. DYSPHAGIA IN ALZHEIMER'S DISEASE
    Jennifer Horner; Fiscal Year: 1992
    ..study as oropharyngeal aspiration or risk for aspiration), will be described using a videofluoroscopic modified barium swallow technique...
  41. IMPLANTABLE MICROELECTRODES USING CVD THIN-FILM BATI03
    MARGARET LANGMUIR; Fiscal Year: 1993
    ..We propose to develop a process for depositing thin films of barium titanate by chemical vapor deposition for this purpose...
  42. PROGNOSIS FOR SWALLOWING FUNCTION RECOVERY FOLLOWING CVA
    Richard Lazar; Fiscal Year: 1992
    ..Clinical dyaphagia evaluation and videofluoroseopy with modified barium swallow (VF/MBS) will be performed 3, 6, 12, and 26 weeks following CVA to determine the presence and severity of ..
  43. BLUE DYE CORRELATION WITH MODIFIED BARIUM SWALLOW TESTS
    THERESE O NEIL PIROZZI; Fiscal Year: 2000
    ..This is a prospective study in which the results of simultaneously administered blue dye and modified barium swallow tests will be tested for degree of correlation.
  44. Effects of LSVT on Dysphagia in Parkinson's Disease
    Jerilyn Logemann; Fiscal Year: 2003
    ..When identified clinically as at-risk for aspiration, patients will receive a modified barium swallow on a standard protocol, followed by randomization to immediate LSVT treatment for 1-month (4 sessions per-..
  45. Oropharyngeal Function After Radiotherapy with IMRT
    Jerilyn A Logemann; Fiscal Year: 2010
    ..This project attempts to quantify the swallow problems associated with this specific treatment and the effects of interventions for these swallow problems. ..
  46. Effects of Swallowing Therapy in Head and Neck Cancer
    Jerilyn Logemann; Fiscal Year: 2006
    ....
  47. INCREASING ACCESS TO CLINICAL AND EDUCATIONAL STUDIES
    Ronald Myers; Fiscal Year: 2004
    ..In Phase 3, we will prepare and submit new research grant applications based on results from the pilot studies. ..
  48. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  49. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  50. Tailored Messaging in Colorectal Cancer Screening
    Ronald Myers; Fiscal Year: 2005
    ..Determine intervention impact on CRC screening utilization, 2. Determine intervention impact on screening decision stage, and 3. Determine intervention impact on patient perceptions about screening. ..
  51. Cannabinoids and Central Neuronal Activity
    Paul Schweitzer; Fiscal Year: 2005
    ..abstract_text> ..
  52. DEVELOPMENTAL CONTROL OF THE DIAPHRAGM AND UPPER AIRWAYS
    William Cameron; Fiscal Year: 2003
    ....
  53. Volume Regulatory Pathways in Cystic Fibrosis Mice
    Won Kyoo Cho; Fiscal Year: 2003
    ..abstract_text> ..
  54. Pathophysiology of glia following traumatic brain injury
    RAIMONDO D AMBROSIO; Fiscal Year: 2005
    ..Investigations on these post-traumatic changes will allow a more rational treatment to TBI. ..
  55. CALCIUM-ACTIVATED POTASSIUM CHANNELS
    Christopher Lingle; Fiscal Year: 2006
    ....
  56. Nitric Oxide and the Liver
    Don Rockey; Fiscal Year: 2003
    ..The dates of the entire AASLD scientific meeting are November 3rd to November 5th. The participants will be invited speakers and attendees of the annual 2002 AASLD meeting. ..
  57. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..These methods will be employed pre- and post-therapy on all patients to assess their potential clinical utility, especially in those unresponsive to medical therapy after aggressive acid suppression. ..
  58. Strategies for Efficient Routes to Bioactive Substances
    Steven Burke; Fiscal Year: 2006
    ..The proposed syntheses are one-third to one-half as long as comparative benchmarks for these targets, illustrating the effectiveness of this developing strategy for dramatically affecting synthetic efficiency. ..
  59. Posttraumatic epilepsy induced by fluid percussion injury in the rat
    RAIMONDO D apos AMBROSIO; Fiscal Year: 2010
    ..abstract_text> ..
  60. DETERMINING/UNDERSTANDING BARRIERS TO ADULT IMMUNIZATION
    Richard Zimmerman; Fiscal Year: 2001
    ..This project will furnish relevant, up-to-date to enhance policy planning, practice management and medical education. ..
  61. MECHANISMS AND FUNCTIONS OF ASTROCYTE CALCIUM SIGNALING
    Andrew Charles; Fiscal Year: 2004
    ....
  62. Expeditious Synthesis of Complexity and Diversity
    Steven Burke; Fiscal Year: 2007
    ....
  63. Tailored Interactive Intervention to Increase CRC Screen
    Sally Vernon; Fiscal Year: 2006
    ..Telephone follow-up and medical record review will be conducted 6 months after delivery of the intervention to ascertain completion of CRCS. ..
  64. RESPIRATORY AND LARYNGEAL DYNAMICS DURING SWALLOW
    Bonnie Martin Harris; Fiscal Year: 2002
    ..Cluster analysis will be applied to identify critical clusters of respiratory-swallowing dynamics. Mixed- effects analysis of variance will estimate the key study parameters of age group specific durations and variability. ..
  65. MOLECULAR AND CELLULAR PHYSIOLOGY OF EPISODIC ATAXIA
    James Maylie; Fiscal Year: 2006
    ..The use of transgenic technology to develop mouse models of disease will permit an understanding of EA1 and the possibility of new pharmacological treatments for this disease. ..
  66. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  67. Embryonic Stem Cell-based Therapies for Myocardial Infarction
    Timothy J Kamp; Fiscal Year: 2010
    ..Overall, these studies will provide new insights into cell-based therapies in the post-MI setting and bring approaches using human ESCs closer to clinical application. ..
  68. PKC modulation of calcium current and anesthetic action
    GANESAN KAMATCHI; Fiscal Year: 2007
    ..abstract_text> ..