Genomes and Genes
Summary: An element that is an alkali metal. It has an atomic symbol Rb, atomic number 37, and atomic weight 85.47. It is used as a chemical reagent and in the manufacture of photoelectric cells.
Publications224 found, 100 shown here
- The structure of the potassium channel: molecular basis of K+ conduction and selectivityD A Doyle
Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Science 280:69-77. 1998..The architecture of the pore establishes the physical principles underlying selective K+ conduction...
- Energetic optimization of ion conduction rate by the K+ selectivity filterJ H Morais-Cabral
Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
Nature 414:37-42. 2001..The energetic balance between these configurations is a clear example of evolutionary optimization of protein function...
- Hydrogen peroxide mediates plant root cell response to nutrient deprivationRyoung Shin
Donald Danforth Plant Science Center, St Louis, MO 63132, USA
Proc Natl Acad Sci U S A 101:8827-32. 2004..ROS production is an early root response to K(+) deficiency that modulates gene expression and physiological changes in the kinetics of K(+) uptake...
- Ion permeation mechanism of the potassium channelJ Aqvist
Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Sweden
Nature 404:881-4. 2000..Other putative permeation pathways can be excluded because they would involve states that are too high in energy...
- In situ Raman probing of graphene over a broad doping range upon rubidium vapor exposureRomain Parret
Laboratoire Charles Coulomb UMR 5221, Universite Montpellier 2, F 34095 Montpellier, France
ACS Nano 7:165-73. 2013..Raman scattering experiments on single-layer graphene (SLG) and Bernal bilayer graphene (BLG) during exposure to rubidium vapor. The G- and 2D-band evolutions with doping time are presented and analyzed...
- Measurement of rubidium and xenon absolute polarization at high temperatures as a means of improved production of hyperpolarized (129)XeN J Shah
Institute of Medicine, Research Centre Julich, 52428 Jülich
NMR Biomed 13:214-9. 2000We report on a rubidium-xenon (Rb-Xe) polarization unit for the continuous production of large quantities of hyperpolarized (129)Xe...
- Adenosine diphosphate as an intracellular regulator of insulin secretionC G Nichols
Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Science 272:1785-7. 1996..Thus, by binding to SUR NBF2 and antagonizing ATP inhibition of KATP++ channels, intracellular MgADP may regulate insulin secretion...
- Interdependence of in-cell xenon density and temperature during Rb/129Xe spin-exchange optical pumping using VHG-narrowed laser diode arraysNicholas Whiting
Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, IL 62901, USA
J Magn Reson 208:298-304. 2011....
- Electronically excited rubidium atom in helium clusters and films. II. Second excited state and absorption spectrumMarkku Leino
Institut de Physique de Rennes, UMR 6251, CNRS and Université de Rennes 1, F 35042 Rennes, France
J Chem Phys 134:024316. 2011Following our work on the study of helium droplets and film doped with one electronically excited rubidium atom Rb(∗) ((2)P) [M. Leino, A. Viel, and R. E. Zillich, J. Chem. Phys...
- Effect of rubidium and cesium ions on the dimeric quaduplex formed by the Oxytricha nova telomeric repeat oligonucleotide d(GGGGTTTTGGGG)Flaminia Cesare Marincola
Dipartimento di Scienze Chimiche, Università di Cagliari Cittadella Universitaria di Monserrato, Monserrato, CA, Italy
Nucleosides Nucleotides Nucleic Acids 26:1129-32. 2007....
- Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter familyC M Gillen
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Biol Chem 271:16237-44. 1996..These data demonstrate that the KCC1 cDNAs encode a widely expressed K-Cl cotransporter with the characteristics of the K-Cl transporter that has been characterized in red cells...
- A conserved arginine near the filter of Kir1.1 controls Rb/K selectivityHenry Sackin
Dept of Physiology, The Chicago Medical School, RFU, IL, USA
Channels (Austin) 4:203-14. 2010..1b causing a subtle change in the selectivity filter, perhaps by disruption of an intra-subunit salt bridge (R128-E118) near the filter...
- Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptorN Inagaki
Division of Molecular Medicine, Chiba University School of Medicine, Japan
Science 270:1166-70. 1995..Gene mapping data show that these two potassium channel subunit genes are clustered on human chromosome 11 at position 11p15.1...
- Development of an HTS assay for Na+, K+-ATPase using nonradioactive rubidium ion uptakeSikander Gill
Aurora Biomed, Inc, Vancouver, BC, Canada V6A 1W2
Assay Drug Dev Technol 2:535-42. 2004A high-throughput screening (HTS) assay was developed for the Na(+),K(+)-ATPase channel in order to study rubidium uptake as a measure of the functional activity and modulation of this exchanger...
- Laboratory evaluation of rubidium as a long-lasting marker for bloodfeeding sand flies (Diptera: Psychodidae)T M Mascari
Louisiana State University Agricultural Center, Agricultural Experiment Station, Department of Entomology, 402 Life Sciences, Baton Rouge, LA 70803, USA
J Med Entomol 49:227-30. 2012The objective of this study was to evaluate the use of the trace element rubidium (Rb) as a long-lasting systemic biomarker for bloodfeeding females of the sand fly Phlebotomus papatasi Scopoli...
- Glucose-induced activation of rubidium transport and water flux in sunflower root systemsJ M Quintero
Departamento de Ciencias Agroforestales, EUITA, Universidad de Sevilla, Ctra. Utrera, Km. 1, E-41013 Sevilla, Spain
J Exp Bot 52:99-104. 2001..cv. Sun-Gro 393) were used to study the effect of different sugars on rubidium and water fluxes...
- Optical pumping system design for large production of hyperpolarizedI C Ruset
Department of Physics, University of New Hampshire, Durham, New Hampshire 03824, USA
Phys Rev Lett 96:053002. 2006..3 l/h Xe flow rate, and maximum magnetization output of 6 l/h at 22% polarization. Our findings regarding the polarization dependence on temperature, nitrogen partial pressure, and gas mixture flow velocity are also reported...
- Characterization of a hERG screen using the IonWorks HT: comparison to a hERG rubidium efflux screenSteve Sorota
Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA steve sorota spcorp com
Assay Drug Dev Technol 3:47-57. 2005..human ethera- go-go-related gene (hERG) patch clamp data and an alternative functional screen based on rubidium flux...
- Characterization of the R162W Kir7.1 mutation associated with snowflake vitreoretinopathyWei Zhang
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
Am J Physiol Cell Physiol 304:C440-9. 2013..Our data suggest that the R162W mutation suppresses Kir7.1 channel activity, possibly by negatively impacting gating by membrane phosphadidylinositol 4,5-bisphosphate...
- Rubidium marking of Anopheles mosquitoes detectable by field-capable X-ray spectrometryE E Wilkins
Centers for Disease Control and Prevention CDC, Atlanta, Georgia, USA
Med Vet Entomol 21:196-203. 2007..stricto (Diptera: Culicidae) and Anopheles stephensi Liston larvae were cultured to pupation in water containing rubidium (Rb) Cl at concentrations up to 1000 p.p.m. Rb...
- Functional analysis of native and recombinant ion channels using a high-capacity nonradioactive rubidium efflux assayG C Terstappen
Bayer AG, Pharma Research Centre, Wuppertal, D 42096, Germany
Anal Biochem 272:149-55. 1999A nonradioactive cell-based rubidium (Rb(+)) efflux assay for functional analysis of native and recombinant ion channels has been developed...
- Expression of KT/KUP genes in Arabidopsis and the role of root hairs in K+ uptakeSung Ju Ahn
Donald Danforth Plant Science Center, 975 North Warson Road, St Louis, Missouri 63132, USA
Plant Physiol 134:1135-45. 2004..This suggests an important role for root hairs in K(+) uptake. The growth and rubidium (Rb(+)) uptake of two root hair mutants, trh1-1 (tiny root hairs) and rhd6 (root hair defective), were studied to ..
- AtKUP1: an Arabidopsis gene encoding high-affinity potassium transport activityE J Kim
Department of Biology, University of California, San Diego, La Jolla 92093, USA
Plant Cell 10:51-62. 1998..It is proposed that plants contain multiple potassium transporters for high-affinity uptake and that the AtKUP family may provide important components of high- and low-affinity K+ nutrition and uptake into various plant cell types...
- Hyperpolarized (129)Xe MRI: a viable functional lung imaging modality?Samuel Patz
Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Eur J Radiol 64:335-44. 2007..We also provide an update on new technological advancements that form the foundation for an improved compact design polarizer as well as improvements that provide another order-of-magnitude scale-up in xenon polarizer output...
- The potassium transporter AtHAK5 functions in K(+) deprivation-induced high-affinity K(+) uptake and AKT1 K(+) channel contribution to K(+) uptake kinetics in Arabidopsis rootsMarkus Gierth
Division of Biological Sciences, Cell and Developmental Biology Section and Center for Molecular Genetics, University of California San Diego, La Jolla, California 92093 0116, USA
Plant Physiol 137:1105-14. 2005..The results demonstrate an in vivo function for AtHAK5 in the inducible high-affinity K(+) uptake system in Arabidopsis roots...
- Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channelsGuiscard Seebohm
Department of Physiology, University of Utah, Salt Lake City, UT USA, Physiologisches Institut I, Tubingen, Germany
J Physiol 552:369-78. 2003....
- Regulation of Na+-K+-2Cl- cotransport by protein phosphorylation in ferret erythrocytesP W Flatman
Membrane Biology Group, Department of Biomedical Sciences, University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
J Physiol 517:699-708. 1999..Phosphorylation of the phosphatase is probably regulated by members of the Src family of tyrosine kinases...
- Ru(bpy)3(2+)-doped silica nanoparticles labeling for a sandwich-type electrochemiluminescence immunosensorXia Yang
Key Laboratory on Luminescence and Real time Analysis, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China
Biosens Bioelectron 25:1851-5. 2010..This new strategy for preparation of the ECL immunosensor could be easily realized and has potential application in ultrasensitive bioassays...
- Activation of ferret erythrocyte Na+-K+-2Cl- cotransport by deoxygenationPeter W Flatman
Membrane Biology Group, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK
J Physiol 563:421-31. 2005..They also indicate that more than one kinase and phosphatase are involved in cotransporter phosphorylation...
- Atomic structure of a Na+- and K+-conducting channelNing Shi
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
Nature 440:570-4. 2006..We conclude that the sequence of the NaK selectivity filter resembles that of a cyclic nucleotide-gated channel and its structure may represent that of a cyclic nucleotide-gated channel pore...
- Functional identification of ion binding sites at the internal end of the pore in Shaker K+ channelsJill Thompson
Department of Pharmacology and Physiology, University of Rochester Medical Center, NY 14642, USA
J Physiol 549:107-20. 2003..These results provide information on the fine-structure of ion interactions with the inner end of the pore in K+ channels...
- Structural rearrangements underlying K+-channel activation gatingE Perozo
Department of Molecular Physiology and Biological Physics and Center for Structural Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22906 0011, USA
Science 285:73-8. 1999..Although the extracellular residues flanking the selectivity filter remained immobile during gating, small movements were detected at the C-terminal end of the pore helix, with possible implications to the gating mechanism...
- Tail end of the s6 segment: role in permeation in shaker potassium channelsShinghua Ding
Department of Physiology, Jefferson Medical College, Philadelphia, PA 19107, USA
J Gen Physiol 120:87-97. 2002..These results indicate that S6(T) residues have an influence on the conformation of the open activation gate, reflected in both the stability of the open state and the energy barriers it presents to ions...
- A mutation in the Arabidopsis KT2/KUP2 potassium transporter gene affects shoot cell expansionRangasamy P Elumalai
Department of Biology, University of North Carolina at Chapel Hill, Coker Hall, Chapel Hill, NC 27599 3280, USA
Plant Cell 14:119-31. 2002..coli mutant. A P(SHY3)::GUS fusion is expressed in growing portions of the plant. These results suggest that KT2/KUP2/SHY3 mediates K(+)-dependent cell expansion in growing tissues...
- Relative contribution of AtHAK5 and AtAKT1 to K+ uptake in the high-affinity range of concentrationsFrancisco Rubio
Departamento de Nutrición Vegetal, Centro de Edafología y Biología Aplicada del Segura CSIC, Apartado de Correos 164, Murcia 30100, Spain
Physiol Plant 134:598-608. 2008....
- The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction ratesYufeng Zhou
Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute and Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
J Mol Biol 333:965-75. 2003..We conclude that electrostatic balance and coupling of ion binding to a protein conformational change underlie high conduction rates in the setting of high selectivity...
- A new family of K+ transporters from Arabidopsis that are conserved across phylaF J Quintero
Laboratory of Plant Physiology and Biophysics, University of London, Wye College, UK
FEBS Lett 415:206-11. 1997..These and additional results suggest that AtKT1 and AtKT2 belong to a superfamily of cation transporters that have been conserved through evolution...
- Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channelsM Pusch
Istituto di Cibernetica e Biofisica, Consiglio Nazionale della Ricerche, Via De Marini 6, I 16149 Genova, Italy
Biophys J 78:211-26. 2000..using the two-electrode voltage-clamp and the patch-clamp technique and high extracellular potassium (K) and rubidium (Rb) solutions...
- A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distributionMing Zhou
Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10021, USA
J Mol Biol 338:839-46. 2004..The mutation does not affect the conduction of Rb(+). These results can be understood in the context of a conduction mechanism in which a pair of K ions switch between energetically balanced 1,3 and 2,4 configurations...
- The Candida albicans Na(+)/H(+) antiporter exports potassium and rubidiumO Kinclová
Department of Membrane Transport, Institute of Physiology, Prague, Czech Republic
FEBS Lett 504:11-5. 2001..A.36) but it transports besides toxic sodium and lithium also rubidium and potassium...
- The effects of elevated glucose on Na+/K(+)-ATPase of cultured bovine retinal pigment epithelial cells measured by a new nonradioactive rubidium uptake assayJ Y Crider
Molecular Pharmacology Unit, Alcon Laboratories, Inc, Fort Worth, Texas, USA
J Ocul Pharmacol Ther 13:337-52. 1997..The results of the present study suggest that hyperglycemia-induced loss of Na+/K(+)-ATPase function in RPE cells, which responds to aldose reductase inhibitor treatment, contributes to the pathogenesis of diabetic retinopathy...
- External TEA block of shaker K+ channels is coupled to the movement of K+ ions within the selectivity filterJill Thompson
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Gen Physiol 122:239-46. 2003....
- Structure of the hydrated and dimethyl sulfoxide solvated rubidium ions in solutionPaola D'Angelo
Dipartimento di Chimica, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, I 00185 Rome, Italy
Inorg Chem 43:3543-9. 2004The structure of the hydrated and the dimethyl sulfoxide solvated rubidium ions in solution has been determined by means of large-angle X-ray scattering (LAXS) and extended X-ray absorption fine structure (EXAFS) studies...
- Ion binding affinity in the cavity of the KcsA potassium channelYufeng Zhou
Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Biochemistry 43:4978-82. 2004..These results are consistent with a fairly large (more negative than -100 mV) electrostatic potential inside the cavity, and they also imply the presence of a weak nonelectrostatic component to a cation's interaction with the cavity...
- Gamma-hydroxybutyrate receptor function determined by stimulation of rubidium and calcium movements from NCB-20 neuronsV Kemmel
Institut de Chimie Biologique and INSERM U 338, Faculte de Medecine, 11 rue Humann, 67085, Strasbourg Cedex, France
Neuroscience 116:1021-31. 2003..This process must at least partially trigger small conductance calcium activated channel activation leading to gamma-hydroxybutyrate-induced hyperpolarization...
- PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)Brian F X Dowd
Yale University, School of Medicine, Department of Cellular and Molecular Physiology, New Haven, Connecticut 06520 0826, USA
J Biol Chem 278:27347-53. 2003..In cells preloaded with 32Pi, the phosphorylation of PASK, but not DNPASK, coincides with that of NKCC1 and increases 5.5 +/- 0.36-fold in low [Cl]e. These data conclusively link PASK with the phosphorylation and activation of NKCC1...
- E2P state stabilization by the N-terminal tail of the H,K-ATPase beta-subunit is critical for efficient proton pumping under in vivo conditionsKatharina L Dürr
Institute of Chemistry, Technical University of Berlin, D 10623 Berlin, Germany
J Biol Chem 284:20147-54. 2009....
- Cloning and functional characterization of the high-affinity K+ transporter HAK1 of pepperM Angeles Martínez-Cordero
Departamento de Nutrición Vegetal, Centro de Edafología y Biología Aplicada del, Segura CSIC, Apartado de Correos 164, Murcia, 30100, Spain
Plant Mol Biol 56:413-21. 2004..3 and 1.9 microM, respectively. Rb+ uptake was competitively inhibited by micromolar concentrations of NH and Cs+, and by millimolar concentrations of Na+...
- Alteration of ionic selectivity of a K+ channel by mutation of the H5 regionA J Yool
Department of Molecular and Cellular Physiology, Stanford University Medical Center, California 94305 5426
Nature 349:700-4. 1991..The mutations that substantially altered selectivity had little effect on the gating properties of the channel. We conclude that the H5 region is likely to line the pore of the K+ channel...
- The ionic environment controls the contribution of the barley HvHAK1 transporter to potassium acquisitionFabiana R Fulgenzi
Instituto de Investigaciones Biotecnologicas, Universidad Nacional de San Martín Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Tecnología Industrial, San Martin 1650, Provincia de Buenos Aires, Argentina
Plant Physiol 147:252-62. 2008..It is shown that the yeast protein phosphatase PPZ1 as well as the halotolerance HAL4/HAL5 kinases negatively regulate the HvHAK1-mediated K+ transport...
- The multi-ion nature of the pore in Shaker K+ channelsP Perez-Cornejo
University of Rochester Medical School, Department of Physiology, New York 14642
Biophys J 66:1929-38. 1994..91; this increased to 1.3 at 40 mM Cs+. We show that a 4-barrier, 3-site permeation model can simulate these and many of the other known properties of ion permeation in Shaker channels...
- Efficiency of rubidium marking in Aedes albopictus (Diptera: Culicidae): preliminary evaluation on persistence of egg labeling, survival, and fecundity of marked femaleRafael Maciel-de-Freitas
Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, 21040 900 Rio de Janeiro, RJ, Brazil
Mem Inst Oswaldo Cruz 99:823-7. 2004b>Rubidium chloride (RbCl) has been used for the study of vector biology and behavior, although the efficacy of marking, egg production, and survivorship of marked females have been poorly studied...
- Protons as substitutes for sodium and potassium in the sodium pump reactionC Polvani
Department of Medicine, McGill University, Montreal, Quebec, Canada
J Biol Chem 263:16757-63. 1988..8. These ATP-dependent cardiac glycoside-sensitive proton movements indicate Na,K-ATPase mediated Na+/H+ exchange in the absence of extracellular K+ as well as H+/K+ exchange in the absence of cytoplasmic Na+...
- A thermodynamic study of electroneutral K-Cl cotransport in pH- and volume-clamped low K sheep erythrocytes with normal and low internal magnesiumP K Lauf
Department of Physiology and Biophysics, Wright State University School of Medicine, Dayton, Ohio 45401 0927, USA
J Gen Physiol 108:341-50. 1996..Thus, basal as well as low internal Mg-stimulated net K-Cl cotransport depends on the electrochemical potential gradient of KCl...
- The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5Didi Baev
Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14214, USA
J Biol Chem 279:55060-72. 2004..albicans...
- Effect of acute hyperglycemia on erythrocyte membrane ion transport in offspring of hypertensive parentsGabriela Suchankova
Diabetes Center, Institute for Clinical and Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic
J Hypertens 21:1325-30. 2003..The aims of this study were to assess RBC ion transport activities under basal conditions and to test the in vivo effect of acute hyperglycemia on RBC ion transport in the offspring of hypertensive parents (OHP) and healthy controls (C)...
- NhaK, a novel monovalent cation/H+ antiporter of Bacillus subtilisMakoto Fujisawa
Graduate School of Life Sciences, Toyo University, 1 1 1 Izumino, Itakura machi, Oura gun, Gunma, 374 0193, Japan
Arch Microbiol 183:411-20. 2005..In addition, the expression level was significantly increased in the presence of added K+ and Na+...
- Intracellular Na concentration and Rb uptake in proximal convoluted tubule cells and abundance of Na/K-ATPase alpha1-subunit in NHE3-/- miceFranz X Beck
Physiologisches Institut der Universitat, Pettenkoferstrasse 12, 80336, Munich, Germany
Pflugers Arch 446:100-5. 2003..There were no significant changes of cell Na concentration and Rb uptake in distal convoluted tubule, connecting tubule, principal and intercalated cells...
- [Potassium transport in erythrocytes from patients with gentamicin intolerance]F V Toropova
Institute of Cytology RAS, St Petersburg
Tsitologiia 44:1194-8. 2002A study was made of rubidium (potassium analog) influxes via ouabain-sensitive Na/K pump, bumetanide-sensitive cotransport and resistant to ouabain bumetanide membrane ion pathways and of the intracellular potassium and sodium contents in ..
- A trapped intracellular cation modulates K+ channel recovery from slow inactivationEvan C Ray
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Gen Physiol 128:203-17. 2006..We propose that the rate of recovery from slow inactivation is determined by the ability of entrapped cations to move into a binding site in the channel's selectivity filter, and refilling of this site is required for recovery...
- Entrance port for Na(+) and K(+) ions on Na(+),K(+)-ATPase in the cytoplasmic loop between trans-membrane segments M6 and M7 of the alpha subunit. Proximity Of the cytoplasmic segment of the beta subunitA Shainskaya
Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel and Department of Biology, University of Konstanz, D-78434 Konstanz, Germany
J Biol Chem 275:2019-28. 2000..2) Na(+) ions specifically protect the 16-kDa fragment against this chymotryptic cleavage...
- K(+) transport in Malpighian tubules of Tenebrio molitor L: a study of electrochemical gradients and basal K(+) uptake mechanismsU I M Wiehart
Department of Zoology and Entomology, University of Pretoria, Pretoria 0002, South Africa
J Exp Biol 206:949-57. 2003..b>Rubidium, a 'permeant' potassium substitute, caused a hyperpolarization of V(bl), indicating the specificity of K(+) ..
- Characterization of potassium transport in wild-type and isogenic yeast strains carrying all combinations of trk1, trk2 and tok1 null mutationsAdam Bertl
Universitat Karlsruhe, Germany
Mol Microbiol 47:767-80. 2003..Based on this finding, we have established a growth-based assay that monitors the in vivo activity of Tok1p...
- Cl secretagogues reduce basolateral K permeability in the rabbit corneal epitheliumO A Candia
Department of Ophthalmology, Mount Sinai School of Medicine, 100th Street and 5th Avenue New York, NY 10029 6574, USA
J Membr Biol 190:197-205. 2002....
- Multiple transport functions of a red blood cell anion exchanger, tAE1: its role in cell volume regulationH Guizouarn
Laboratoire de Physiologie des Membranes Cellulaires, UMR 6078, , , 284 chemin du Lazaret, 06230 Villefranche-sur-Mer, France
J Physiol 535:497-506. 2001..6. tAE1 illustrates the ability of a specific transport system to be a multifunctional protein exhibiting other transport functions when submitted to regulation...
- Effects of palytoxin on cation occlusion and phosphorylation of the (Na+,K+)-ATPaseM T Tosteson
Laboratory for Membrane Transport, Department of Cell Biology, Harvard Medical School, One Kendall Square, Building 600 Third Floor, Cambridge, MA 02139, USA
J Membr Biol 192:181-9. 2003....
- Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channelsHarley T Kurata
Department of Cellular and Physiological Sciences, University of British Columbia, 2146 Health Sciences Mall, Vancouver B C V6T 1Z3, Canada
J Physiol 568:31-46. 2005..Collectively, these data distinguish between open-state and closed-state inactivation, and suggest the presence of multiple possible mechanisms of inactivation coexisting in Kv1 channels...
- Regulation of potassium transport in human lens epithelial cellsPeter K Lauf
Cell Biophysics Group, Wright State University School of Medicine, Dayton, OH 45435, USA
Exp Eye Res 82:55-64. 2006..The data suggest at least partial inverse regulation of KCC and NKCC in HLE-B3 cells by signaling cascades involving serine, threonine and tyrosine phosphorylation/dephosphorylation equilibria...
- Cation transport activity of anion exchanger 1 mutations found in inherited distal renal tubular acidosisStephen Walsh
Laboratoire de Physiologie des Membranes Cellulaires, UMR6548, Centre National de la Recherche Scientifique Université de Nice, Bâtiment de Sciences Naturelles, Nice, France
Am J Physiol Renal Physiol 295:F343-50. 2008..These findings have potential structural and functional implications for AE1, and they indicate that while anion exchange and cation conductance properties are distinct, they can coexist...
- The schiff base of gossypol with 3,6,9,12,15,18,21,24-octaoxa-pentacosylamine complexes and monovalent cations studied by electrospray ionization-mass spectrometry, (1)H nuclear magnetic resonance, Fourier transform infrared, as well as PM5 semiempirical Piotr Przybylski
Faculty of Chemistry, A Mickiewicz University, Grunwaldzka 6, 60 780 Poznan, Poland
Biopolymers 74:273-86. 2004..The two protons are localized on the N atoms of the Schiff base, and the complex exists in the imine-imine tautomeric form. The structures of the complexes are calculated by PM5 semiempirical methods and discussed...
- Inhibition of delayed rectifier K(+)-current by levcromakalim in single intestinal smooth muscle cells: effects of cations and dependence on K(+)-fluxD McHugh
Department of Pharmacology, University of Leeds
Br J Pharmacol 114:391-9. 1995....
- L-rhamnulose 1-phosphate aldolase from Escherichia coli. Crystallization and propertiesT H Chiu
Biochemistry 8:98-108. 1969
- A role for the non-phosphorylated form of yeast Snf1: tolerance to toxic cations and activation of potassium transportFrancisco Portillo
Instituto de Investigaciones Biomedicas, Universidad Autónoma de Madrid C S I C, Arturo Duperier 4, 28029 Madrid, Spain
FEBS Lett 579:512-6. 2005..The effect of Snf1 on Trk is probably indirect and could be mediated by the Sip4 transcriptional activator...
- Sodium and potassium transport in the halophilic yeast Debaryomyces hanseniiJ C González-Hernández
Departamento de Genetica y Biologia Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Apartado 70 242, 04510 Mexico D F, Mexico
Yeast 21:403-12. 2004..It can be concluded that Na(+) in D. hansenii is not excluded but instead, its metabolic systems must be resistant to high salt concentrations...
- High temperature NMR study of the local structure of molten LaF3-AF (A = Li, Na, K and Rb) mixturesAnne Laure Rollet
Centre de Recherche sur les Matériaux à Haute Température CNRS, Orleans cedex 2, France
Phys Chem Chem Phys 10:3222-8. 2008..The coordination number of lanthanum is decreased versus AF amount all the more since the alkali atomic number is high. Moreover, the more polarisable the alkali, the less bridging fluorines between the LaF(x) units...
- The link between ion permeation and inactivation gating of Kv4 potassium channelsMohammad Shahidullah
Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Biophys J 84:928-41. 2003..By examining possible changes in ionic selectivity and the influence of elevating the external K(+) concentration, additional experiments did not support the presence of C-type inactivation in Kv4 channels...
- The selectivity filter of the tandem pore potassium channel TASK-1 and its pH-sensitivity and ionic selectivityK Yuill
Molecular Physiology Group, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
Pflugers Arch 448:63-9. 2004..39+/-0.03 (n=14) in H98D, 0.64+/-0.04 (n=18) in D204H and 0.33+/-0.07 (n=3) in D204N. Thus, the arrangement of ring of residues HDHD appears to optimise both pH sensitivity and ionic selectivity...
- Selective binding of monovalent cations to the stacking G-quartet structure formed by guanosine 5'-monophosphate: a solid-state NMR studyAlan Wong
Department of Chemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
J Am Chem Soc 125:13895-905. 2003..We have demonstrated that solid-state (23)Na and (15)N NMR can be used simultaneously to provide mutually complementary information about competitive binding between Na(+) and NH(4)(+) ions...
- Potassium channel, ions, and water: simulation studies based on the high resolution X-ray structure of KcsACarmen Domene
Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Biophys J 85:2787-800. 2003..A preliminary comparison of the use of particle mesh Ewald versus cutoff protocols for the treatment of long-range electrostatics suggests some difference in the kinetics of ion translocation within the filter...
- K(+) transport and volume regulatory response by NKCC in resting rat hindlimb skeletal muscleMichael I Lindinger
Dept of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
Cell Physiol Biochem 12:279-92. 2002..The hypertonic perfusate also resulted in temporally associated decreases in net water uptake by muscle. It is concluded that a functional NKCC is present in mammalian skeletal muscle and that it is involved in cell volume regulation...
- Metallic content of wines from the Canary Islands (Spain). Application of artificial neural networks to the data analysisSergio Frías
Department of Analytical Chemistry, Nutrition and Food Science, University of La Laguna, Santa Cruz de Tenerife, Spain
Nahrung 46:370-5. 2002..Thus, Lanzarote presented the highest mean content in sodium and lithium and the lowest mean content in rubidium, and La Palma presented the highest mean content in strontium and rubidium...
- A greater stimulation of Na-H antiport in cultured vascular smooth muscle cells by serum from spontaneously hypertensive ratsS Kuriyama
Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Am J Hypertens 4:780-2. 1991..The study suggests that there are humoral factors in SHR serum which elicit the stimulation of the Na-H antiport, leading to the activation of the Na-K pump of VSMC...
- Analysis of the monovalent ion fluxes in U937 cells under the balanced ion distribution: recognition of ion transporters responsible for changes in cell ion and water balance during apoptosisA A Vereninov
Institute of Cytology RAS, Tikhoretsky Avenue 4, 194064 St Petersburg, Russia
Cell Biol Int 31:382-93. 2007....
- Low-affinity potassium uptake by Saccharomyces cerevisiae is mediated by NSC1, a calcium-blocked non-specific cation channelHermann Bihler
Botanisches Institut, Lehrstuhl I, Universitat Karlsruhe, Germany
Biochim Biophys Acta 1558:109-18. 2002..Growth inhibition by lithium ions is probably a toxic effect, whereas growth inhibition by ammonium ions probably results from competitive inhibition, i.e. displacement of intracellular potassium by entering ammonium...
- Plasma-membrane Cnh1 Na+/H+ antiporter regulates potassium homeostasis in Candida albicansOlga Kinclova-Zimmermannova
Department of Membrane Transport, Institute of Physiology AS CR, v v i, Videnska 1083, 142 20 Prague 4 Krc, Czech Republic
Microbiology 153:2603-12. 2007..The potassium and rubidium tolerance of a cnh1 homozygous mutant was fully restored by reintegration of CNH1 into the genome...
- The KCl cotransporter isoform KCC3 can play an important role in cell growth regulationM R Shen
University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, United Kingdom
Proc Natl Acad Sci U S A 98:14714-9. 2001..Tumor necrotic factor-alpha down-regulates KCC3 expression and causes growth arrest. These data indicate that KCC3 is an important KCC isoform that may be involved in cell proliferation...
- Fusicoccin- and IAA-induced elongation growth share the same pattern of K+ dependenceK Tode
, Ohnhorststr. 18, D-22609 Hamburg, Germany
J Exp Bot 52:251-5. 2001..However, TEA abolished this apparently K+ independent FC-induced growth. It is concluded that FC-induced growth, like auxin-induced growth, requires K+ uptake through K+ channels...
- Gating properties of inward-rectifier potassium channels: effects of permeant ionsH Choe
Department of Physiology and Biophysics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
J Membr Biol 184:81-9. 2001..The patterns of voltage-dependence of closed-state lifetimes, which are specific for different ions, can be explained by variations in the rate at which the bound ions leave the pore toward the inside or the outside of the cell...
- Mutational effects on conformational changes of the dephospho- and phospho-forms of the Na+,K+-ATPaseM Toustrup-Jensen
Department of Physiology, University of Aarhus, , DK-8000 Aarhus C, Denmark
Biochemistry 40:5521-32. 2001....
- Characterization of glial cell K-Cl cotransportKenneth B E Gagnon
Cell Biophysics Group, Wright State University, Dayton, OH 4543, USA
Cell Physiol Biochem 20:121-30. 2007..The molecular mechanism of K-Cl cotransport (KCC) consists of at least 4 isoforms, KCC 1, 2, 3, and 4 which, in multiple combinations, exist in most cells, including erythrocytes and neuronal cells...
- Rubidium chloride tolerant callus cultures of rice (Oryza sativa L.) accumulate more potassium and cross tolerate to other saltsR Naga Amrutha
Department of Genetics, Osmania University, Hyderabad 500 007, India
Plant Cell Rep 26:1647-62. 2007..were established in Murashige and Skoog's (MS) medium containing lethal concentrations (50 mM) of rubidium chloride (RbCl) as a selective agent...
- Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic gangliaD M Liu
School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane, Queensland 4072, Australia
J Physiol 534:423-35. 2001..The relative permeabilities of the monovalent inoganic and organic cations tested are similar to those reported previously for cloned rat P2X(2) receptors expressed in mammalian cells...
- Sodium fluxes through nonselective cation channels in the plasma membrane of protoplasts from Arabidopsis rootsVadim Demidchik
Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA United Kingdom
Plant Physiol 128:379-87. 2002..It is suggested that NSCCs present a distinct group of plant ion channels, mediating toxic Na(+) influx to the cell and probably having other important roles in physiological processes of plants...
- Capillary electrophoresis of anionic analytes in methanol: effect of counter-ions on electrophoretic mobilitySimo P Porras
Laboratory of Analytical Chemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland
Electrophoresis 23:367-74. 2002..Exceptions are some di- and trihydroxybenzoates. The mobilities in methanol and in water with the same counter-ion (Na+) at a given ionic concentration show very low correlation...
- Potassium drives daily reversible thallus enlargement in the marine red alga Porphyra leucosticta (Rhodophyta)Luis Escassi
Departamento de Ecologia, Universidad de Malaga, Campus Universitatio de Teatinos s n, 29071 Malaga, Spain
Planta 214:759-66. 2002..The possible effects of the loosening of the cell wall and the internal K+ concentration on the growth of this species are also discussed...
- Influence of permeating ions on Kv1.5 channel block by nifedipineS Lin
Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
Am J Physiol Heart Circ Physiol 280:H1160-72. 2001..This is consistent with the conclusion that nifedipine block and C-type inactivation in the Kv1.5 channel can coexist but are mediated by distinct mechanisms coordinated by outer pore conformation...
- Comparison of K-Cl cotransport expression in high and low K dog erythrocytesHideharu Ochiai
Research Institute of Biosciences, Azabu University, Sagamihara, Kanagawa, Japan
Exp Anim 55:57-63. 2006..These results suggest that the difference in cotransport activity was not caused by the amount of K-Cl cotransport protein but by a difference in the regulation system, which is susceptible to oxidant...
- Apparent intermediate K conductance channel hyposmotic activation in human lens epithelial cellsPeter K Lauf
Cell Biophysics Group, 054 Biological Sciences Bldg, Wright State Univ Boonshoft School of Medicine, Dayton, OH 45435, USA
Am J Physiol Cell Physiol 294:C820-32. 2008..1 channels, aside of the KCC1, KCC2, KCC3 and KCC4 isoforms. Apparently, IK channels, possibly in parallel with volume-sensitive outwardly rectifying Cl channels, effect regulatory volume decrease in LECs...
- Molecular analysis of the mechanism of potassium uptake through the TRK1 transporter of Saccharomyces cerevisiaeRosario Haro
Departamento de Biotecnologia, Escuela Tecnica Superior de Ingenieros Agronomos, Universidad Politecnica de Madrid, Spain
Biochim Biophys Acta 1564:114-22. 2002..ScTRK1 mediates active K(+) uptake. This is not Na(+)-coupled and direct coupling of ScTRK1 to a source of chemical energy seems more probable than K(+)-H(+) cotransport...
- Fast network oscillations induced by potassium transients in the rat hippocampus in vitroFiona E N LeBeau
School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, UK
J Physiol 542:167-79. 2002Brief pressure ejection of solutions containing potassium, caesium or rubidium ions into stratum radiatum of the CA1 or CA3 regions of the hippocampal slice evoked a fast network oscillation...
- Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experimentsV Tereshko
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
Nucleic Acids Res 29:1208-15. 2001..Conversely, high resolution of the data alone does not necessarily allow differentiation between water and partially ordered metal ions, as demonstrated with the crystal structure of a DNA duplex determined to a resolution of 0.6 A...
- Development of a5* nAChR positive allosteric modulators for tobacco dependenceJON MARTIN LINDSTROM; Fiscal Year: 2013..In addition, we will also test novel a5* nAChR PAMs in a rubidium (86Rb+) efflux assay using synaptosomes from a brain region in which nAChRmediated currents are almost exlusively ..
- Chronic Nicotine Effects on Receptor SubtypesNorman H Lee; Fiscal Year: 2013..of chronic nicotine exposure on expression (using autoradiography and immunoprecipitation) and function (using rubidium efflux and neurotransmitter release) of nAChR subtypes, alteration of neuronal morphology (measuring dendritic ..
- PATHOGENESIS OF HERPETIC KERATITISWILLIAM O BRIEN; Fiscal Year: 2002..Pump function will be measured by rubidium uptake and enzyme activity by phosphate release from ATP...
- Brain K+ Dynamics, BBB Breakdown & Hemorrhagic Transformation in Ischemic StrokeStephen Jones; Fiscal Year: 2009..We will use K/Rb substitution MRI to observe this [K+]brfall. Rubidium-87, but not K, can be effectively observed with MRI,acts as a congener of K+, and can be substituted for K (18%) ..
- TRACE ELEMENT NUTRITION OF THE LENS--ZINCJ Bentley; Fiscal Year: 1990..by oxidative agents will be studied by, in vitro, by measuring changes in their permeability, using the isotope rubidium-86...
- INORGANIC ION EXCHANGER FOR USE IN 82SR/82RB SEPARATIONSPaul Sylvester; Fiscal Year: 2000..82Sr is produced by the irradiation of rubidium or molybdenum targets followed by the extraction of 82Sr using ion exchange techniques...
- Mechanisms of serum electrolyte effects on block of HERGAlan Miller; Fiscal Year: 2006..channels or mutant HERG channels to study the mechanisms by which the extracellular monovalent cations potassium, rubidium, and cesium and the divalent cations calcium and magnesium alter block of HERG by a number of different compounds ..
- OPTIMIZED STRESS STATES IN CERAMIC-BASED RESTORATIONSKenneth Anusavice; Fiscal Year: 2003..prostheses, 3) single and double ion-exchange strengthening treatments based on potassium-enriched and rubidium-enriched slurries that are fired at low temperatures over short time periods, and 4) micro-miniature ..
- FLOW, GLUCOSE METABOLISM AND MYOCARDIAL VIABILITY BY PETRichard Brunken; Fiscal Year: 1991..kinetic models reparations with the goal of making accurate, noninvasive measurements of myocardial blood flow (rubidium-82, N-13 ammonia) and glucose utilization (F-18 deoxyglucose in vivo with PET...
- FUNCTIONAL ACTIVITY OF MESOLIMBIC NICOTINIC RECEPTORSPETER ROWELL; Fiscal Year: 2001..The nicotine-stimulated efflux of rubidium following various nicotine treatment schedules, coupled with assays of nicotine brain levels and receptors, will ..
- Atomic BiomagnetometerTHAD WALKER; Fiscal Year: 2006..The specific aims are: 1. To build a optical magnetometer/gradiometer that utilizes rubidium atoms and achieves a magnetic field sensitivity 10A-14 T/(Hz)A1/2. 2...
- NUCLEOTIDE CHANGES WITH AGGRESSION-ALTERING DRUGSBurr Eichelman; Fiscal Year: 1980..g., 6-hydroxydopamine, monoamine oxidase inhibitors, dibenzazepines, and rubidium) and drugs which have been reported to decrease aggression (beta blockers, neuroleptics and lithium)...
- MYOCARDIUM INFARCT SIZING BY 82RB EMISSION TOMOGRAPHYSTEPHEN DERENZO; Fiscal Year: 1980..and resolution with which one can define myocardial infarction and ischemia using the positron emitting isotope rubidium-82 and carbon-11 amino acids. Rubidium-82 (75 sec...
- SHORT TERM REGULATION OF THE NA+ PUMPCarlos Pedemonte; Fiscal Year: 2001..and amino-terminus mutants of the rodent alpha subunit expressed in OK cells and will involve measurements of rubidium, ATPase activities and changes in intracellular sodium concentrations. The second aim has two parts...
- Proteomics of M-L antigens modulating cation transportPETER LAUF; Fiscal Year: 2004....
- Third Symposium Cell Volume & Signalling RegulationPETER LAUF; Fiscal Year: 2003..This meeting's success on U.S. soil will foster continuation of gathering of high-caliber scientists at subsequent international meetings ..
- OXIDATIVE STRESS AND CATARACT FORMATIONShambhu D Varma; Fiscal Year: 2010..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..
- From Clinic to Bench and Back: Clinical Biodetective Training(RMI)Mark Milanick; Fiscal Year: 2008..e., approaches that can be used in family practice settings, by nurses and nurse practitioners, and by patients for self monitoring) in situations where the patient and clinician are not necessarily in a hospital setting. ..
- PATHOGENS, PROBIOTICS AND THE EPITHELIUM IN COLITISKim Barrett; Fiscal Year: 2007..It may also provide a scientific rationale for continued exploration of probiotics, promising complementary/alternative therapies, in the treatment of inflammatory bowel disease and other intestinal disorders. ..
- MECHANISMS OF SULFATE TRANSPORT AND REGULATIONMichael Jennings; Fiscal Year: 2007..abstract_text> ..
- SHARED INSTRUMENTATION GRANTZsolt Szabo; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Endothelin Receptor Imaging of Cancer with PETZsolt Szabo; Fiscal Year: 2007..They have the potential to improve selection of cancer patients for treatment with endothelin antagonists. [unreadable] [unreadable] [unreadable]..
- Realistic Phantom Series for OLINDA/EXM Version 2Michael Stabin; Fiscal Year: 2007..unreadable] [unreadable]..
- PET DETECTION OF THE EFFECTS OF AGING ON THE HUMAN HEARTROBERT GROPLER; Fiscal Year: 2007..As a result, potentially new targets could be identified for novel therapeutics designed to treat various cardiac disorders that increase with age and potentially slow the impact of aging on the human heart. ..
- Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric DisordersAlvin V Terry; Fiscal Year: 2010..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..
- Fluid Movement across Conjunctiva: Stimulation and RegulationOSCAR CANDIA; Fiscal Year: 2007..These studies may provide the groundwork for the design of future treatment modalities for dry-eye syndromes. ..
- MOLECULAR CLONING OF EPITHELIAL K CHANNELSHenry Sackin; Fiscal Year: 2008..A thorough characterization of their gating is essential for understanding the molecular basis of a variety of channelopathies. ..
- From Clinic to Bench & Back: Clinical Biodetective Training (RMI)Mark Milanick; Fiscal Year: 2008..e., approaches that can be used in family practice settings, by nurses and nurse practitioners, and by patients for selfmonitoring) in situations where the patient and clinician are not necessarily in a hospital setting. ..
- CYCLOTRON PRODUCED ISOTOPES IN BIOLOGY AND MEDICINEROBERT GROPLER; Fiscal Year: 2008..The three research projects will be supported by three Cores; specifically, an administration core, a cyclotron/radiopharmaceutical core, and an instrument/data processing core. ..
- Ion Regulation of Kv Channel Gating and PermeationCarol Deutsch; Fiscal Year: 2007..The second aim will test whether ions in the selectivity filter modulate the movement of voltage sensors. These studies will entail measurements of kinetics and voltage dependence of gating currents in HEK cells. ..
- New Methods for Improved Image-based DosimetryMichael Stabin; Fiscal Year: 2006..unreadable] [unreadable]..
- Radiopharmaceutical Dosimetry SymposiumMichael Stabin; Fiscal Year: 2002..abstract_text> ..
- SICKLING MECHANISMS AND RED CELL MEMBRANESROBERT BOOKCHIN; Fiscal Year: 2002..Once characterized, these will serve investigations within the above three aims. ..
- PET IMAGING OF THE 5HT TRANSPORTER IN ALCOHOLISMZsolt Szabo; Fiscal Year: 2003..The results of this project will lead to better understanding of the role of serotonin in the biological vulnerability for alcoholism and may lead to improved approaches to prevent and treat alcoholism. ..
- SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVAOSCAR CANDIA; Fiscal Year: 2002..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
- NMDA RECEPTOR--AGONIST AFFINITY, EFFICACY/TRANSDUCTIONAntonius VanDongen; Fiscal Year: 2004..These studies will result in a detailed molecular picture of the dynamic change in structure that accompany activation of the NMDA receptor. ..
- CYTOSOLIC MODULATION OF PLASMA MEMBRANE ION TRANSPORTMark Milanick; Fiscal Year: 2005..abstract_text> ..
- PET Quantification of Myocardial Substrate MetabolismROBERT GROPLER; Fiscal Year: 2006..The various PET techniques will be developed and validated against a variety of biochemical markers in a well-controlled canine model studied under a wide range of substrate, hormonal and workload conditions. ..
- Antipsychotics: Temporal Effects on Cognitive FunctionAlvin Terry; Fiscal Year: 2006..unreadable] [unreadable]..
- INTESTINAL SECRETORY MECHANISMSKim Barrett; Fiscal Year: 2005..Ultimately, improved knowledge of such abnormalities may improve therapies for these conditions. ..
- Effects of Glycosylation on RBC Ca2+ Pump in DiabetesROBERT BOOKCHIN; Fiscal Year: 2006..unreadable] [unreadable]..
- Measurement of Fluid Flow Across the Ocular Ciliary BodyOSCAR CANDIA; Fiscal Year: 2006..abstract_text> ..
- Infrastructure and Applications of Hyperpolarized 129XeSamuel Patz; Fiscal Year: 2006..A polarizer will be built, sited and supported at Brigham and Women's Hospital. Animal and human studies are proposed to demonstrate the structural and functional information 129Xe MRI can provide. ..
- GAS EXCHA03NGE IMAGING IN THE LUNG USING MRISamuel Patz; Fiscal Year: 2001..Early detection of the loss of alveolar surface area is a serious public health imperative, since chronic obstructive pulmonary disease is now the Th leading cause of death in the US. ..