potassium

Summary

Summary: An element that is in the alkali group of metals. It has an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte and it plays a significant role in the regulation of fluid volume and maintenance of the water-electrolyte balance.

Top Publications

  1. ncbi Crystal structure of parallel quadruplexes from human telomeric DNA
    Gary N Parkinson
    The Cancer Research UK Biomolecular Structure Unit, Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Nature 417:876-80. 2002
  2. ncbi Urinary sodium and potassium excretion and risk of cardiovascular events
    MARTIN J O'DONNELL
    Population Health Research Institute, Hamilton General Hospital, McMaster University, 237 Barton St E, Third Floor, Hamilton, ON, L8L 2X2, Canada
    JAMA 306:2229-38. 2011
  3. ncbi Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold
    Kim Ngoc Luu
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 128:9963-70. 2006
  4. ncbi Regulation of ion homeostasis under salt stress
    Jian Kang Zhu
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Curr Opin Plant Biol 6:441-5. 2003
  5. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
  6. ncbi Molecular background of leak K+ currents: two-pore domain potassium channels
    Peter Enyedi
    Department of Physiology, Semmelweis University, Budapest, Hungary
    Physiol Rev 90:559-605. 2010
  7. ncbi Crystal structure of the sodium-potassium pump at 2.4 A resolution
    Takehiro Shinoda
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Nature 459:446-50. 2009
  8. ncbi A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    M C Sanguinetti
    Eccles Program in Human Molecular Biology and Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    Cell 81:299-307. 1995
  9. ncbi Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
    Olaf Gross
    III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Nature 459:433-6. 2009
  10. ncbi Structure of human telomeric DNA in crowded solution
    Brahim Heddi
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    J Am Chem Soc 133:9824-33. 2011

Detail Information

Publications345 found, 100 shown here

  1. ncbi Crystal structure of parallel quadruplexes from human telomeric DNA
    Gary N Parkinson
    The Cancer Research UK Biomolecular Structure Unit, Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Nature 417:876-80. 2002
    ..This DNA structure suggests a straightforward path for telomere folding and unfolding, as well as ways in which it can recognize telomere-associated proteins...
  2. ncbi Urinary sodium and potassium excretion and risk of cardiovascular events
    MARTIN J O'DONNELL
    Population Health Research Institute, Hamilton General Hospital, McMaster University, 237 Barton St E, Third Floor, Hamilton, ON, L8L 2X2, Canada
    JAMA 306:2229-38. 2011
    The precise relationship between sodium and potassium intake and cardiovascular (CV) risk remains uncertain, especially in patients with CV disease.
  3. ncbi Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold
    Kim Ngoc Luu
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 128:9963-70. 2006
    ..The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA...
  4. ncbi Regulation of ion homeostasis under salt stress
    Jian Kang Zhu
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Curr Opin Plant Biol 6:441-5. 2003
    ..The protein kinase complex then phosphorylates and activates various ion transporters, such as the plasma membrane Na(+)/H(+) antiporter SOS1...
  5. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
    ..Activation of the Nalp3 inflammasome by silica required both an efflux of intracellular potassium and the generation of reactive oxygen species...
  6. ncbi Molecular background of leak K+ currents: two-pore domain potassium channels
    Peter Enyedi
    Department of Physiology, Semmelweis University, Budapest, Hungary
    Physiol Rev 90:559-605. 2010
    ..In this review, we focus on the physiological roles of K(2P) channels in the most extensively investigated cell types, with special emphasis on the molecular mechanisms of channel regulation...
  7. ncbi Crystal structure of the sodium-potassium pump at 2.4 A resolution
    Takehiro Shinoda
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Nature 459:446-50. 2009
    Sodium-potassium ATPase is an ATP-powered ion pump that establishes concentration gradients for Na(+) and K(+) ions across the plasma membrane in all animal cells by pumping Na(+) from the cytoplasm and K(+) from the extracellular medium...
  8. ncbi A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    M C Sanguinetti
    Eccles Program in Human Molecular Biology and Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    Cell 81:299-307. 1995
    ..Since block of IKr is a known mechanism for drug-induced cardiac arrhythmias, the finding that HERG encodes IKr channels provides a mechanistic link between certain forms of inherited and acquired LQT...
  9. ncbi Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
    Olaf Gross
    III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Nature 459:433-6. 2009
    ..uses the Card9 pathway, inflammasome activation by the fungus involves reactive oxygen species production and potassium efflux. Genetic deletion or pharmalogical inhibition of Syk selectively abrogated inflammasome activation by C...
  10. ncbi Structure of human telomeric DNA in crowded solution
    Brahim Heddi
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    J Am Chem Soc 133:9824-33. 2011
    ..These results regarding human telomeric DNA can be extended to oncogenic promoters and other genomic G-rich sequences...
  11. pmc Structural mechanism of C-type inactivation in K(+) channels
    Luis G Cuello
    Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Illinois 60637, USA
    Nature 466:203-8. 2010
    ..These structures indicate a molecular basis for C-type inactivation in K(+) channels...
  12. ncbi Crystal structure of the sodium-potassium pump
    J Preben Morth
    Centre for Membrane Pumps in Cells and Disease PUMPKIN, Danish National Research Foundation, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    Nature 450:1043-9. 2007
    The Na+,K+-ATPase generates electrochemical gradients for sodium and potassium that are vital to animal cells, exchanging three sodium ions for two potassium ions across the plasma membrane during each cycle of ATP hydrolysis...
  13. ncbi Crystal structure of a mammalian voltage-dependent Shaker family K+ channel
    Stephen B Long
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 309:897-903. 2005
    Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action ..
  14. ncbi A rice quantitative trait locus for salt tolerance encodes a sodium transporter
    Zhong Hai Ren
    National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, The Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Nat Genet 37:1141-6. 2005
    ..Physiological analysis suggested that SKC1 is involved in regulating K(+)/Na(+) homeostasis under salt stress, providing a potential tool for improving salt tolerance in crops...
  15. pmc Phylogenetic relationships within cation transporter families of Arabidopsis
    P Maser
    Division of Biology, Cell and Developmental Biology Section and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0116, USA
    Plant Physiol 126:1646-67. 2001
    ..gene families for which initial characterizations have been achieved for individual members, including potassium transporters and channels, sodium transporters, calcium antiporters, cyclic nucleotide-gated channels, cation ..
  16. ncbi The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
    The potassium channel from Streptomyces lividans is an integral membrane protein with sequence similarity to all known K+ channels, particularly in the pore region. X-ray analysis with data to 3...
  17. ncbi KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel
    H S Wang
    Institute of Molecular Cardiology, Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Science 282:1890-3. 1998
    ..The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.
  18. ncbi Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
    Laure Gurcel
    Department Microbiology and Molecular Medicine, University of Geneva, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Cell 126:1135-45. 2006
    ..Here we show that toxin-induced membrane permeabilization leads to a decrease in cytoplasmic potassium, which promotes the formation of a multiprotein oligomeric innate immune complex, called the inflammasome, and ..
  19. ncbi Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
    S G Brickley
    Department of Pharmacology, University College London, London WC1E 6BT, UK
    Nature 409:88-92. 2001
    ....
  20. ncbi Potassium transport and plant salt tolerance
    Sergey Shabala
    School of Agricultural Science, University of Tasmania, Private Bag 54, Hobart, Tasmania 7001, Australia
    Physiol Plant 133:651-69. 2008
    ..In this paper, we discuss an alternative approach, reviewing the molecular and ionic mechanisms contributing to potassium homeostasis in salinized plant tissues and discussing prospects for breeding for salt tolerance by targeting ..
  21. ncbi Implication of Kir4.1 channel in excess potassium clearance: an in vivo study on anesthetized glial-conditional Kir4.1 knock-out mice
    Oana Chever
    Department of Stomatology, Universite de Montreal, Montreal, Quebec H3T 1J4, Canada
    J Neurosci 30:15769-77. 2010
    ..membrane potential of glial cells, and it is believed to play a main role in the homeostasis of extracellular potassium. To understand its importance in these two phenomena, we have measured in vivo the variations of extracellular ..
  22. pmc Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation
    Iskandar F Abdullaev
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 5:e12304. 2010
    ..Some studies have suggested that calcium-activated potassium channels contribute to the high proliferative potential of tumor cells, including gliomas...
  23. pmc Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers
    Kah Wai Lim
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    J Am Chem Soc 131:4301-9. 2009
    ..This novel structure highlights the conformational heterogeneity of human telomeric DNA. It establishes a new folding principle for G-quadruplexes and suggests new loop sequences and structures for targeting in human telomeric DNA...
  24. ncbi Salinity tolerance in halophytes
    Timothy J Flowers
    School of Life Sciences, University of Sussex, Falmer, Brighton, Sussex, BN1 9QG, UK
    New Phytol 179:945-63. 2008
    ....
  25. pmc Extreme conformational diversity in human telomeric DNA
    J Y Lee
    Department of Physics, Seoul National University, Seoul 151 742, Korea
    Proc Natl Acad Sci U S A 102:18938-43. 2005
    ..Three conformations were observed in potassium solution, one unfolded and two folded, and each conformation could be further divided into two species, long-..
  26. pmc MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation
    Xiaobin Luo
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    J Clin Invest 123:1939-51. 2013
    ..Our results demonstrate that miR-26 controls the expression of KCNJ2 and suggest that this downregulation may promote AF...
  27. ncbi Serum potassium levels and mortality in acute myocardial infarction
    Abhinav Goyal
    Department of Medicine, Emory School of Medicine, Atlanta, GA 30322, USA
    JAMA 307:157-64. 2012
    Clinical practice guidelines recommend maintaining serum potassium levels between 4.0 and 5.0 mEq/L in patients with acute myocardial infarction (AMI)...
  28. pmc Potassium buffering in the central nervous system
    P Kofuji
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Neuroscience 129:1045-56. 2004
    ..We also discuss intriguing new data that suggest a close physical and functional relationship between Kir and water channels in glial cells...
  29. ncbi Crystal structure of the human two-pore domain potassium channel K2P1
    Alexandria N Miller
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Science 335:432-6. 2012
    Two-pore domain potassium (K(+)) channels (K2P channels) control the negative resting potential of eukaryotic cells and regulate cell excitability by conducting K(+) ions across the plasma membrane. Here, we present the 3...
  30. ncbi Multiple regulatory sites in large-conductance calcium-activated potassium channels
    Xiao Ming Xia
    Department of Anesthesiology, Washington University School of Medicine, Box 8054, St Louis, Missouri 63110, USA
    Nature 418:880-4. 2002
    ..This allows BK channels to serve a variety of physiological roles contingent on the Ca(2+) concentration to which the channels are exposed...
  31. pmc Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal
    Jing Li
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Nucleic Acids Res 33:4649-59. 2005
    ..These models suggest that the biologically relevant structure of the human telomere quadruplex in K+ solution is not the one determined in the published crystalline state...
  32. ncbi Small-conductance, calcium-activated potassium channels from mammalian brain
    M Kohler
    Vollum Institute, L 474, Oregon Health Sciences University, 3181 Southwest Sam Jackson Road, Portland, OR 97201, USA J Maylie, Department of Obstetrics and Gyne
    Science 273:1709-14. 1996
    Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain...
  33. pmc Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis
    Verónica Barragán
    Instituto de Recursos Naturales y Agrobiologia, Consejo Superior de Investigaciones Cientificas, Sevilla 41012, Spain
    Plant Cell 24:1127-42. 2012
    ..Together, these results show that tonoplast-localized NHX proteins are essential for active K(+) uptake at the tonoplast, for turgor regulation, and for stomatal function...
  34. pmc Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
    Susan L Fink
    Molecular and Cellular Biology Program, Departments of Microbiology and Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:4312-7. 2008
    ..active LF cleaved cytosolic substrates and activated caspase-1 by a mechanism involving proteasome activity and potassium efflux. LT activation of caspase-1 is known to require the inflammasome adapter Nalp1...
  35. ncbi Blocker protection in the pore of a voltage-gated K+ channel and its structural implications
    D del Camino
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 403:321-5. 2000
    The structure of the bacterial potassium channel KcsA has provided a framework for understanding the related voltage-gated potassium channels (Kv channels) that are used for signalling in neurons...
  36. ncbi Two types of HKT transporters with different properties of Na+ and K+ transport in Oryza sativa
    T Horie
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma-shi, Nara 630-0101, Japan
    Plant J 27:129-38. 2001
    ..These results suggest that two isoforms of HKT transporters, a Na+ transporter (OsHKT1) and a Na+- and K+-coupled transporter (OsHKT2), may act harmoniously in the salt tolerant indica rice...
  37. ncbi Potassium and sodium transport in non-animal cells: the Trk/Ktr/HKT transporter family
    C Corratgé-Faillie
    Biochimie et Physiologie Moleculaire des Plantes, Institut de Biologie Integrative des Plantes, UMR 5004 CNRS UMR 0386 INRA Montpellier SupAgro Université Montpellier 2, 2 place Viala, Montpellier Cedex 2, France
    Cell Mol Life Sci 67:2511-32. 2010
    ..Elucidation of Trk/Ktr/HKT protein structures along with characterization of mutated transporters could highlight functional and evolutionary relationships between ion channels and transporters displaying channel-like features...
  38. pmc How long is too long? Effects of loop size on G-quadruplex stability
    Aurore Guédin
    INSERM, U869, European Institute of Chemistry and Biology, Bordeaux 2 University, 2 rue Robert Escarpit, Pessac F 33607, France
    Nucleic Acids Res 38:7858-68. 2010
    ..Unsurprisingly, the melting temperature was systematically lower in sodium than in potassium but the difference between both ionic conditions varied between 1 and >39°C (average difference: 18.3°C)...
  39. pmc Potassium softens vascular endothelium and increases nitric oxide release
    H Oberleithner
    Institute of Physiology II, University of Munster, D 48149 Munster, Germany
    Proc Natl Acad Sci U S A 106:2829-34. 2009
    ..We now demonstrate effects of extracellular potassium on stiffness of individual cultured bovine aortic endothelial cells by using the tip of an atomic force ..
  40. ncbi Parallel G-quadruplex-specific fluorescent probe for monitoring DNA structural changes and label-free detection of potassium ion
    Tao Li
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China
    Anal Chem 82:7576-80. 2010
    ..These results reveal that PPIX is promising for use as a specific DNA structural probe in sensing applications...
  41. ncbi Energetics of ion conduction through the K+ channel
    S Berneche
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nature 414:73-7. 2001
    ..Ion-ion repulsion, although essential for rapid conduction, is shown to act only at very short distances. The calculations show also that the rapidly conducting pore is selective...
  42. pmc Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase
    Najwane Saïd-Sadier
    Health Sciences Research Institute and School of Natural Sciences, University of California Merced, Merced, California, USA
    PLoS ONE 5:e10008. 2010
    ....
  43. ncbi Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution
    Y Zhou
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nature 414:43-8. 2001
    ..This structural change is crucial to the operation of the selectivity filter in the cellular context, where the K+ ion concentration near the selectivity filter varies in response to channel gating...
  44. pmc Transcript profile of the response of two soybean genotypes to potassium deficiency
    Cheng Wang
    National Center for Soybean Improvement, National Key Laboratory for Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, China
    PLoS ONE 7:e39856. 2012
    The macronutrient potassium (K) is essential to plant growth and development. Crop yield potential is often affected by lack of soluble K...
  45. ncbi Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake
    Elisabet Miro-Casas
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119, Barcelona 08035, Spain
    Cardiovasc Res 83:747-56. 2009
    ..Connexin43 is present at the inner membrane of cardiomyocyte mitochondria (mCx43), but its function remains unknown...
  46. ncbi Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    Stephanie C Eisenbarth
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 453:1122-6. 2008
    ..This is likely to affect how we design effective, but safe, adjuvants in the future...
  47. ncbi TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices
    Min Zhou
    Ordway Research Institute, Albany, New York 12208, USA
    J Neurosci 29:8551-64. 2009
    ..These results support TWIK-1 and TREK-1 as being the major components of the long-sought K(+) channels underlying the passive conductance of mature hippocampal astrocytes...
  48. ncbi Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation
    Biljana Djukic
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:11354-65. 2007
    During neuronal activity, extracellular potassium concentration ([K+]out) becomes elevated and, if uncorrected, causes neuronal depolarization, hyperexcitability, and seizures...
  49. ncbi Structural, biochemical, and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel
    Maria J Marques-Carvalho
    Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    J Mol Biol 423:34-46. 2012
    KCNH channels are voltage-gated potassium channels with important physiological functions...
  50. ncbi PSP toxin release from the cyanobacterium Raphidiopsis brookii D9 (Nostocales) can be induced by sodium and potassium ions
    Katia Soto-Liebe
    Pontificia Universidad Catolica de Chile, Facultad de Ciencias Biologicas, Alameda 340, 8331150 Santiago, Chile
    Toxicon 60:1324-34. 2012
    ..We propose that these toxins in cyanobacteria could act extracellularly as a protective mechanism to ensure homeostasis against extreme salt variation in the environment...
  51. pmc Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial
    Harry P Selker
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    JAMA 307:1925-33. 2012
    Laboratory studies suggest that in the setting of cardiac ischemia, immediate intravenous glucose-insulin-potassium (GIK) reduces ischemia-related arrhythmias and myocardial injury...
  52. pmc Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation
    Dengguo Wei
    CRUK Biomolecular Structure Group, UCL School of Pharmacy, University College London, 29 39 Brunswick Square, WC1N 1AX, London, UK
    Nucleic Acids Res 40:4691-700. 2012
    ..The structure reveals that potassium and magnesium ions have an unexpected yet significant structural role in stabilizing particular quadruplex loops ..
  53. pmc Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution
    Xiao Tao
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA
    Science 326:1668-74. 2009
    Inward-rectifier potassium (K+) channels conduct K+ ions most efficiently in one direction, into the cell...
  54. ncbi The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus
    Anke Wallraff
    Department of Experimental Neurobiology, Neurosurgery, University of Bonn, 53105 Bonn, Germany
    J Neurosci 26:5438-47. 2006
    Astrocytic gap junctions have been suggested to contribute to spatial buffering of potassium in the brain. Direct evidence has been difficult to gather because of the lack of astrocyte-specific gap junction blockers...
  55. pmc Transcriptome analysis of rice root responses to potassium deficiency
    Tian Li Ma
    State Key Laboratory of Plant Physiology and Biochemistry SKLPPB, National Plant Gene Research Centre Beijing, College of Biological Sciences, China Agricultural University, 2 West Yuan Ming Yuan Rd, Beijing 100193, China
    BMC Plant Biol 12:161. 2012
    b>Potassium (K+) is an important nutrient ion in plant cells and plays crucial roles in many plant physiological and developmental processes...
  56. pmc On the selective ion binding hypothesis for potassium channels
    Ilsoo Kim
    Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 108:17963-8. 2011
    ....
  57. ncbi Potassium-lead-switched G-quadruplexes: a new class of DNA logic gates
    Tao Li
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
    J Am Chem Soc 131:15082-3. 2009
    ..Such a K(+)-Pb(2+) switched G-quadruplex, in fact, functions as a two-input INHIBIT logic gate. With the introduction of another input EDTA, this G-quadruplex can be further utilized to construct a reversibly operated IMPLICATION gate...
  58. pmc The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking
    Christopher L Brett
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Biol Cell 16:1396-405. 2005
    ..This presents the newly defined family of eukaryotic endosomal NHE as novel targets for pharmacological inhibition to alleviate pathological states associated with organellar alkalinization...
  59. ncbi Impact of aquaporin-4 channels on K+ buffering and gap junction coupling in the hippocampus
    Susan Strohschein
    Institute of Cellular Neurosciences, University of Bonn, Bonn, Germany
    Glia 59:973-80. 2011
    ..These findings highlight the role of AQP4 channels in the regulation of K(+) homeostasis...
  60. pmc Root apoplastic barriers block Na+ transport to shoots in rice (Oryza sativa L.)
    Pannaga Krishnamurthy
    National Centre for Biological Sciences, TIFR, Bangalore 560065, India
    J Exp Bot 62:4215-28. 2011
    ..Overall the data suggest that in rice roots Na(+) bypass flow is reduced by the deposition of apoplastic barriers, leading to improved plant survival under salt stress...
  61. ncbi Stimulation of the potassium sensor KdpD kinase activity by interaction with the phosphotransferase protein IIA(Ntr) in Escherichia coli
    Denise Lüttmann
    Georg August Universitat Gottingen, Abteilung für Allgemeine Mikrobiologie, Institut fur Mikrobiologie und Genetik, Grisebachstrasse 8, D 37077 Gottingen, Germany
    Mol Microbiol 72:978-94. 2009
    ..Recently, it was shown that dephosphorylated IIA(Ntr) binds and inhibits TrkA, a low-affinity potassium transporter...
  62. pmc Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation
    Robert L Abraham
    Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 1285A MRB IV, 2311 Pierce Avenue, Nashville, TN 37232 6602, USA
    J Mol Cell Cardiol 48:181-90. 2010
    ..the Vanderbilt AF Registry, we found a mutation in KCNQ1 (encoding the alpha-subunit of slow delayed rectifier potassium current [I(Ks)]) and separately a mutation in natriuretic peptide precursor A (NPPA) gene (encoding atrial ..
  63. ncbi Ion conduction pore is conserved among potassium channels
    Z Lu
    Department of Physiology, University of Pennsylvania, Philadelphia 19104, USA
    Nature 413:809-13. 2001
    b>Potassium channels, a group of specialized membrane proteins, enable K+ ions to flow selectively across cell membranes. Transmembrane K+ currents underlie electrical signalling in neurons and other excitable cells...
  64. ncbi Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness
    S M Pogwizd
    Department of Medicine, University of Illinois, Chicago, IL, USA
    Circ Res 88:1159-67. 2001
    ..The inward rectifier potassium current (I(K1)) is reduced by 49% in HF, and this allows greater depolarization for a given NaCaX current...
  65. ncbi Potassium, phosphorus, or nitrogen limit root allocation, tree growth, or litter production in a lowland tropical forest
    S Joseph Wright
    Smithsonian Tropical Research Institute, Apartado 0843 03092, Balboa, Republic of Panama
    Ecology 92:1616-25. 2011
    We maintained a factorial nitrogen (N), phosphorus (P), and potassium (K) addition experiment for 11 years in a humid lowland forest growing on a relatively fertile soil in Panama to evaluate potential nutrient limitation of tree growth ..
  66. ncbi Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1
    E A Nagelhus
    Nordic Centre of Excellence for Research in Water Imbalance Related Disorders and Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, POB 1105 Blindern, N 0317 Oslo, Norway
    Neuroscience 129:905-13. 2004
    ..The subcellular compartmentation of AQP4 mimics that of the potassium channel Kir4.1, which is implicated in spatial buffering of K(+)...
  67. pmc Potassium deficiency induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thaliana
    Stephanie Troufflard
    Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    BMC Plant Biol 10:172. 2010
    ..Whether and how K deficient plants also alter their secondary metabolism for nutrient management and defense is not known...
  68. ncbi Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs
    Gui Rong Li
    Department of Medicine, Li Ka Shing Faculty of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Rd, Pokfulam, Hong Kong SAR, China
    Circulation 117:2449-57. 2008
    ..The present study investigated whether the natural flavone acacetin from the traditional Chinese medicine Xuelianhua would be an atrium-selective anti-AF agent...
  69. ncbi Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel
    David T Wang
    Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, New South Wales, Australia
    Nat Struct Mol Biol 18:35-41. 2011
    The potassium channel selectivity filter both discriminates between K(+) and sodium ions and contributes to gating of ion flow...
  70. pmc Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis
    Ali A Abdul-Sater
    Health Sciences Research Institute and School of Natural Sciences, University of California, Merced, California 95343, USA
    J Biol Chem 284:26789-96. 2009
    ..Here we show that, in cervical epithelial cells, caspase-1 activation is required for optimal growth of the intracellular chlamydiae...
  71. pmc Cation binding to 15-TBA quadruplex DNA is a multiple-pathway cation-dependent process
    Roman V Reshetnikov
    Department of Boiengineering and Bioinformatics, Lomonosov Moscow State University, GSP 1, Leninskie Gory, Moscow, 119991, Russian Federation
    Nucleic Acids Res 39:9789-802. 2011
    ..The incoming ion then readily replaces the bound ion while minimizing any destabilization of the solute molecule during the exchange...
  72. ncbi Potassium homeostasis and renin-angiotensin-aldosterone system inhibitors
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, Room N3W143, Baltimore, MD 21201, USA
    Clin J Am Soc Nephrol 5:531-48. 2010
    ..aldosterone receptor antagonists, and direct renin inhibitors) increase the risk of hyperkalemia (serum potassium >5.5 mmol/L). This review evaluates the effects on serum potassium levels of RAAS inhibitors...
  73. pmc The frequency of hyperkalemia and its significance in chronic kidney disease
    Lisa M Einhorn
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arch Intern Med 169:1156-62. 2009
    ..Hyperkalemia is a potential threat to patient safety in chronic kidney disease (CKD). This study determined the incidence of hyperkalemia in CKD and whether it is associated with excess mortality...
  74. pmc Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
    Attila Ambrus
    College of Pharmacy, The University of Arizona, 1703 E Mabel St, Tucson, AZ 85721, USA
    Nucleic Acids Res 34:2723-35. 2006
    ....
  75. ncbi Ca(2+)-activated K+ channels: molecular determinants and function of the SK family
    Martin Stocker
    Wellcome Laboratory for Molecular Pharmacology, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 5:758-70. 2004
    ....
  76. pmc Arrangements of human telomere DNA quadruplex in physiologically relevant K+ solutions
    D Renciuk
    Nucleic Acids Res 37:6625-34. 2009
    ....
  77. ncbi Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
    V Petrilli
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, Center of Immunology Lausanne, Epalinges 1066, Switzerland
    Cell Death Differ 14:1583-9. 2007
    ..Thus, low intracellular K(+) may be the least common trigger of NALP-inflammasome activation...
  78. ncbi Reactive oxygen species and root hairs in Arabidopsis root response to nitrogen, phosphorus and potassium deficiency
    Ryoung Shin
    Donald Danforth Plant Science Center, 975 North Warson Rd, St Louis, MO 63132, USA
    Plant Cell Physiol 46:1350-7. 2005
    ..Reactive oxygen species (ROS) have been shown to play a role in root response to potassium deprivation...
  79. pmc Energetics and kinetics of a conformational switch in G-quadruplex DNA
    Robert D Gray
    James Graham Brown Cancer Center, University of Louisville, 529 South Jackson Street, Louisville, Kentucky 40202, USA
    J Phys Chem B 113:2676-83. 2009
    ..of the human telomere quadruplex formed by the sequence d[AGGG(TTAGGG)3] between the sodium basket form and the potassium hybrid form. The energy barrier separating the two conformations was found to be modest, only 1.4-2...
  80. ncbi Expression of an inward-rectifying potassium channel by the Arabidopsis KAT1 cDNA
    D P Schachtman
    Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Science 258:1654-8. 1992
    Inward-rectifying potassium channels located in the plasma membrane of higher plant and animal cells contribute to cellular homeostasis and excitability...
  81. ncbi SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis
    Rebecca S Ginger
    Unilever Corporate Research, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, England, United Kingdom
    J Biol Chem 283:5486-95. 2008
    ..Multiple sequence alignments predict that this gene encodes a member of the potassium-dependent sodium-calcium exchanger family denoted NCKX5...
  82. ncbi Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments
    Rainer Breitling
    Plant Science Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    FEBS Lett 573:83-92. 2004
    ..In addition, using RP can lead to a sharp reduction in the number of replicate experiments needed to obtain reproducible results...
  83. ncbi Sodium and potassium in the pathogenesis of hypertension
    Horacio J Adrogue
    Department of Medicine, Baylor College of Medicine, Houston, USA
    N Engl J Med 356:1966-78. 2007
  84. pmc hERG potassium channel gating is mediated by N- and C-terminal region interactions
    Ahleah S Gustina
    Program in Neuroscience and 2 Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gen Physiol 137:315-25. 2011
    Human ether-á-go-go-related gene (hERG) potassium channels have voltage-dependent closing (deactivation) kinetics that are unusually slow...
  85. ncbi mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels
    A Butler
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110
    Science 261:221-4. 1993
    Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes...
  86. ncbi Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels
    Devin K Binder
    Department of Neurological Surgery, University of California, San Francisco, 94110, USA
    Glia 53:631-6. 2006
    The glial water channel aquaporin-4 (AQP4) has been hypothesized to modulate water and potassium fluxes associated with neuronal activity...
  87. ncbi Energetic optimization of ion conduction rate by the K+ selectivity filter
    J H Morais-Cabral
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nature 414:37-42. 2001
    ..The energetic balance between these configurations is a clear example of evolutionary optimization of protein function...
  88. pmc Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?
    Yaron David
    Department of Physiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Neurosci 29:10588-99. 2009
    ..These changes predict reduced clearance capacity for both extracellular glutamate and potassium. Electrophysiological recordings in vitro confirmed the reduced clearance of activity-dependent accumulation of ..
  89. ncbi Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila
    D M Papazian
    Science 237:749-53. 1987
    ..locus of Drosophila melanogaster has been proposed to encode a structural component of a voltage-dependent potassium channel, the A channel...
  90. ncbi The voltage-gated potassium channels and their relatives
    Gary Yellen
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 419:35-42. 2002
    The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins...
  91. ncbi Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation
    J A Payne
    Department of Human Physiology, University of California, School of Medicine, Davis 95616, USA
    Am J Physiol 273:C1516-25. 1997
    ....
  92. ncbi Plant responses to potassium deficiencies: a role for potassium transport proteins
    M K Ashley
    Division of Biology, Imperial College London, Wye Campus, Wye, Ashford TN25 5AH, Kent, UK
    J Exp Bot 57:425-36. 2006
    The availability of potassium to the plant is highly variable, due to complex soil dynamics, which are strongly influenced by root-soil interactions...
  93. pmc Mutations in the K+ channel signature sequence
    L Heginbotham
    Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115
    Biophys J 66:1061-7. 1994
    b>Potassium channels share a highly conserved stretch of eight amino acids, a K+ channel signature sequence. The conserved sequence falls within the previously defined P-region of voltage-activated K+ channels...
  94. pmc The potassium transporter AtHAK5 functions in K(+) deprivation-induced high-affinity K(+) uptake and AKT1 K(+) channel contribution to K(+) uptake kinetics in Arabidopsis roots
    Markus Gierth
    Division of Biological Sciences, Cell and Developmental Biology Section and Center for Molecular Genetics, University of California San Diego, La Jolla, California 92093 0116, USA
    Plant Physiol 137:1105-14. 2005
    b>Potassium is an important macronutrient and the most abundant cation in plants. Because soil mineral conditions can vary, plants must be able to adjust to different nutrient availabilities...
  95. ncbi Potassium channels in plant cells
    Ingo Dreyer
    Centro de Biotecnología y Genómica de Plantas, Universidad Politecnica de Madrid, Madrid, Spain
    FEBS J 278:4293-303. 2011
    b>Potassium (K(+) ) is the most abundant inorganic cation in plant cells. Unlike animals, plants lack sodium/potassium exchangers. Instead, plant cells have developed unique transport systems for K(+) accumulation and release...
  96. ncbi Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges
    Sarah M Webster
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 428:864-8. 2004
    Voltage-gated potassium channels such as Shaker help to control electrical signalling in neurons by regulating the passage of K+ across cell membranes...
  97. pmc Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells
    Zhenghang Zhao
    Department of Pharmacology, School of Medicine, Xi an Jiaotong University, Xi an, China
    Cardiovasc Res 95:308-16. 2012
    The transient outward potassium current (I(to)) plays important roles in action potential (AP) morphology and dynamics; however, its role in the genesis of early afterdepolarizations (EADs) is not well understood...
  98. ncbi Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition study
    A A Welch
    Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 63:S101-21. 2009
    ..This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study...
  99. ncbi Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channel
    D del Camino
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 32:649-56. 2001
    ..Either these Kv channels have a broader inner entrance than seen in the KcsA crystal, even in the closed state, or the region is highly flexible (but nevertheless remains very securely closed nearby)...
  100. ncbi KT/HAK/KUP potassium transporters gene family and their whole-life cycle expression profile in rice (Oryza sativa)
    Madhur Gupta
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan, 430070, China
    Mol Genet Genomics 280:437-52. 2008
    KT/HAK/KUP potassium transporter protein-encoding genes constitute a large family in the plant kingdom. The KT/HAK/KUP family is important for various physiological processes of plant life...
  101. ncbi Regulation and mechanism of potassium release from barley roots: an in planta 42K+ analysis
    Devrim Coskun
    Department of Biological Sciences, University of Toronto, 1265 Military Trail, Toronto, ON, Canada
    New Phytol 188:1028-38. 2010
    b>Potassium (K(+) ) flux into plant cells is a well-characterized ion transport phenomenon. By contrast, little is known about the mechanisms and regulation of K(+) flux from the cell...

Research Grants75

  1. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ..developments, however, suggest that highly effective drugs can be developed: Two drugs that influence neuronal potassium channels have been shown to ameliorate cerebellar deficits in humans and mice, and may provide starting points ..
  2. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..effects is unknown but a good candidate is the a3 Na,K-ATPase (NKA), a neuron-specific isoform of the sodium-potassium pump that binds all forms of agrin...
  3. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..I elucidated the roles of sarcolemmal inward rectifier (Kir2.x) potassium channel proteins in the maintenance of VF, and of the ryanodine receptor type 2 in the initiation of ventricular ..
  4. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..I elucidated the roles of sarcolemmal inward rectifier (Kir2.x) potassium channel proteins in the maintenance of VF, and of the ryanodine receptor type 2 in the initiation of ventricular ..
  5. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The sodium-potassium adenosine triphosphatase (i.e. Na,K-ATPase) is responsible for controlling cellular fluid and electrolyte balance in higher eukaryotes...
  6. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..our working hypothesis is that two steroid-responsive mechanisms exist in the ear: a direct sodium and potassium transport (ion homeostatic) gene expression mediated by the mineralocorticoid receptor, and an indirect ..
  7. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..The SLC12 family of cation-chloride cotransporters, which includes sodium-chloride, sodium-potassium-two-chloride, and potassium-chloride cotransporters (NCC, NKCC, and KCC), plays a key role in renal epithelial ..
  8. Parvalbumin-Containing Neurons in Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2013
    ..PV neuronal dysfunction via at least two mechanisms: oxidative stress and decreased expression of voltage-gated potassium channels Kv3.1b and Kv3.2, which play a critical role in conferring the fast-spiking properties to PV neurons...
  9. Transcriptional Regulation of Natriuetic Sensitivity in Diabetes Mellitus
    PATIENCE O OBIH; Fiscal Year: 2012
    ..as indices of activity of sodium chloride co-transporter (NCC), sodium hydrogen exchanger (NHE) and sodium-potassium chloride cotransporter (NKCC), respectively...
  10. METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIA
    DOUGLAS CORBETT HEIMBURGER; Fiscal Year: 2010
    ..examinations, and dietary recalls 6 times in the first 3 months of ART, and measuring serum levels of phosphate, potassium, magnesium, glucose, and albumin...
  11. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..With the voltage-gated potassium channel Kv1...
  12. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..Furthermore, animal feed recalls by FDA from 2009-2012 have included 10 contamination events from zinc, potassium, copper, and molybdenum...
  13. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    ..Given that African Americans have a higher prevalence of obesity and lower dietary potassium intake compared to Caucasians (these factors affect blood pressure), a stronger emphasis on lifestyle ..
  14. Understanding thyroid hormone regulation of neurogenesis in the cochlea
    Mirna Mustapha; Fiscal Year: 2013
    ..congenital, secondary hypothyroidism using physiological tests of exocytosis and measurement of both calcium and potassium currents, 2) Identify a novel set of thyroid hormone regulated genes that affect axonal guidance and ..
  15. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..This proposal focuses on the voltage-gated Kv1.3 potassium channel in TEM cells as a therapeutic target for autoimmune diseases...
  16. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..The specific aim is to test the hypothesis that pubertal changes in calcium (Ca2+) and calcium-activated potassium (K(Ca)) channel activity in GnRH neurons underlie the pubertal increase in GnRH secretion...
  17. C. Elegans and Mitochondrial K+ Channels
    KEITH W NEHRKE; Fiscal Year: 2013
    ..In particular, ion channels in the inner mitochondrial membrane that transport potassium (KATP and KCa channels) are believed to attenuate the mitochondrial cell death response following ..
  18. Mechanisms of Ventricular Tachycardia in Lipotoxic Cardiomyopathy
    JOHN PEARCE MORROW; Fiscal Year: 2013
    ..individual cardiac myocytes from these cells have prolonged action potential duration, probably from reduced potassium current...
  19. Mechanism and functional role of AKAP79/150 in M current control and excitability
    Mark S Shapiro; Fiscal Year: 2010
    ..We will study the regulation of the M-type potassium ion channel, which plays dominant role in regulation of nerve-cell excitability, mediated by the A-kinase ..
  20. Vascular effects of dietary salt in humans with salt-resistant BP
    William B Farquhar; Fiscal Year: 2013
    ..g salt diet for 7 days, and a 20 g salt diet for 7 days (crossover design, diet order sequence randomized;fixed potassium intake)...
  21. Regulation of ENaC Transcription
    Bruce C Kone; Fiscal Year: 2013
    ..Abnormal expression levels of this protein can result in hypertension, potassium deficiency, and edema...
  22. Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    Heike Wulff; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Small-conductance calcium activated potassium channels are encoded by the KCa2.1-2...
  23. New Peptides for the Treatment of Multiple Sclerosis
    Christine Beeton; Fiscal Year: 2013
    ..use a multi-disciplinary, structure-based approach to developing novel polypeptide blockers of the voltage-gated potassium channel Kv1.3 as new interventions for MS...
  24. Phospholemman and Cardiac Contracility
    Joseph Y Cheung; Fiscal Year: 2013
    ..mice specifically engineered to critically evaluate whether regulation of sodium-calcium exchanger or sodium-potassium pump is the major mechanism by which phospholemman affects heart contraction...
  25. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    JOHN PETER contact WIKSWO; Fiscal Year: 2010
    ..dye-based fluorescence imaging of transmembrane potential, Vm;cytosolic calcium, [Ca2+]i;extracellular potassium, [K+]e;and reactive oxygen species, ROS;and ultraviolet autofluorescence measurement of reduced nicotinamide ..
  26. Endothelial Lipoxygenase Metabolites and Vascular Tone
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2013
    ..It relax arteries, in part, by activating apamin-sensitive, small conductance, calcium-activated potassium (SKCa) channels and hyperpolarizing smooth muscle cells (SMCs). It also acts by inhibition of RhoA activation...
  27. Redox Regulation of Kv Channels
    SRINIVAS TIPPARAJU; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Voltage-gated potassium channels (Kv) maintain the resting membrane potential and the shape of the action potential...
  28. Regulation of Adrenal Vascular Tone by Steroidogenic Cells
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2013
    ..Aldosterone regulates sodium and potassium balance and blood pressure. Adrenal blood flow (ABF) is critical to both aldosterone synthesis and action...
  29. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    ..This proposal is designed to test the hypothesis that estrogen regulates endothelial potassium channels to modulate vascular reactivity and blood pressure.)
  30. Epigenetic modulation of epileptogenesis.
    PEYMAN GOLSHANI; Fiscal Year: 2010
    ..that demethylation of DNA leads to dysregulation of ion channel expression, with down-regulation of the A-type potassium channel, kv4.2. Interestingly, down-regulation of dendritic kv4...
  31. SK channels: Roles and mechanisms for dendritic excitability and plasticity
    James G Maylie; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Neurons express a family of calcium-activated potassium channels (SK channels) that are implicated in the molecular and cellular mechanisms underlying learning and ..
  32. Determinants of developing efferent synapses in the mammalian cochlea
    ISABELLE CATHERINA ROUX; Fiscal Year: 2013
    ..acetylcholine receptors (nAChRs) and is inhibitory due to the subsequent activation of calcium-dependent potassium channels...
  33. Analysis of distal conboluted tubule function in vivo
    James A McCormick; Fiscal Year: 2012
    ..These parameters will be studied on a normal diet, and on diets in which sodium and potassium levels have been modified. The ability of thiazides to normalize any defects will be assessed...
  34. Physiology and Biophysics of Cardiac Slo2.1 Channels
    Alexey V Zaitsev; Fiscal Year: 2012
    ..A plethora of potassium-selective ion channels are expressed in the human heart and are important components of the electrical activity ..
  35. Intraocular pressure regulation via ATP-sensitive potassium channels
    Michael F Romero; Fiscal Year: 2013
    ..the molecular events involved in intraocular pressure (IOP) regulation through adenosine-triphosphate-sensitive potassium (KATP) channels. Elevated IOP is the only treatable risk-factor for glaucoma...
  36. HEMOPROTEIN OXIDATION AND HEME CATABOLISM
    Paul R Ortiz de Montellano; Fiscal Year: 2013
    ..HO-1 has no cysteines. HO-2 has been specifically shown to be involved in the regulation of a potassium channel and control of a circadian rhythm clock...
  37. Hydrogen Peroxide and Flow-Induced Dilation of Human Coronary Microcirculation
    David D Gutterman; Fiscal Year: 2012
    ..2) Using a novel bioassay technique to assess vasodilation and smooth muscle potassium channel opening, we shall identify the endothelial derived hyperpolarizing factor (EDHF) responsible for ..
  38. The microglial potassium channels Kv1.3 and KCa3.1 as therapeutic targets for neu
    Heike Wulff; Fiscal Year: 2013
    ..As a first step towards translating our findings to humans, we will further obtain brain sections from stroke patients and controls and perform immunohistochemistry for KCa3.1, Kv1.3, and microglia activation markers. ..
  39. MYOCARDIAL PERFUSION IN THE HYPERTROPHIED HEART
    ROBERT JAMES BACHE; Fiscal Year: 2010
    ..Since little information is available regarding ATP-sensitive potassium channel (KATP) function in the failing heart, the goal of this proposal is to determine whether maladaptive ..
  40. Role of Astrocytic TREK-2 Potassium Channels in Cerebral Ischemia
    Misty J Eaton; Fiscal Year: 2013
    ..brain, are essential for neuronal viability and stimulation of key astrocytic functions such as glutamate and potassium homeostasis in ischemic or post-ischemic brain could potentially contribute to neuroprotection...
  41. Embryonic regulation of GnRH neuron migration and function
    David J Kozlowski; Fiscal Year: 2012
    ..Conversely, we will use a GnRH neuron-specific transgene to overexpress a human inward rectifying potassium channel only in GnRH neurons and silence electrical activity during migration...
  42. Excitability mechanisms of neurocardiac regulation
    ALBERT E GLASSCOCK; Fiscal Year: 2012
    ..in two different epilepsy mouse models of brain-driven cardiac dysfunction linked to SUDEP: 1) a Kcna1 potassium channel knockout mouse model, which exhibits cardiac defects despite minimal cardiac expression;and 2) a Kcnq1 ..
  43. Pharmacology of Intravesical Antisense Based Therapy for Over Active Bladder
    Naoki Yoshimura; Fiscal Year: 2013
    ..Secondly, we will also test the hypothesis of OAB pathology triggered by changes in voltage- gated sodium and potassium channels, increased cytokines expression/release as well as muscarinic receptors, and such changes are mediated ..
  44. Gender differences in aortic baroreceptor function and neural integration
    John H Schild; Fiscal Year: 2013
    ..of myelinated ABN from females, this unique subset expresses BKCa channels that provide ~25% of the whole cell potassium current...
  45. Molecular mechanisms of auditory nAChR synapse assembly
    Michele H Jacob; Fiscal Year: 2013
    ..the functional coupling and close positioning of [unreadable]9/10-nAChRs to small conductance calcium activated potassium channels (SK2)...
  46. Mitochondrial Kv1.3 potassium channels and lymphocyte apoptosis in sepsis
    Jay Yang; Fiscal Year: 2011
    ..The key role of plasma membrane Kv1.3 potassium channels in the activation of T lymphocytes has been recognized for some time...
  47. Skeletal muscle ATP-sensitive potassium channels determine bodily energy balance
    Leonid Zingman; Fiscal Year: 2013
    ..Understanding these mechanisms will provide novel avenues for targeted management and prevention of obesity and related disease and future translational research. ..
  48. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2013
    ..genes that code for a neurotransmitter receptor (P2Y4), an enzyme (guanylyl cyclase), a calcium-activated potassium channel (SK3), and a component of the gap junction (connexin 43)...
  49. Validity of Diet and Activity Measures in Men
    Meir Stampfer; Fiscal Year: 2013
    ..doubly-labeled water (DLW), four 24-hour urinary measures of nitrogen (a measure of protein intake), sodium and potassium, and two fasting blood samples for assessment of fatty acids, standard lipids, carotenoids, and folate...
  50. Functions of 5'NCRs of picornavirus and cellular mRNAs
    Bert L Semler; Fiscal Year: 2013
    ..have been identified in the long 5'NCRs of two cellular mRNA molecules, one that encodes a voltage-gated potassium channel (Kv1.4) and one that encodes a transcription factor (LEF-1)...
  51. STRUCTURAL STUDIES ON PROKARYOTIC POTASSIUM CHANNELS
    Adrian Gross; Fiscal Year: 2013
    ..b>Potassium channels are the phylogenetic founders of a large superfamily of structurally related ion channels that includes ..
  52. Epigenetic Regulation of Kir4.1 and GLT1 in Pathophysiology
    Michelle L Olsen; Fiscal Year: 2013
    ..These two astrocytic functions are largely mediated via the inwardly-rectifying potassium channel, Kir4.1, and the astrocytic glutamate transporter, GLT-1...
  53. Inhibition of chloride secretion by cigarette smoke
    JAMES LEVIN KREINDLER; Fiscal Year: 2010
    ..via oxidation-dependent inhibition of the cAMP-dependent apical anion conductance and inhibits the sodium, potassium, chloride cotransporter...
  54. Molecular mechanisms of potassium channel permeation and gating
    Crina M Nimigean; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Potassium (K+) channels are major determinants of cell excitability and play crucial roles in many physiological processes...
  55. Voltage-Gating in Bacterial Ion Channels
    Ana M Correa; Fiscal Year: 2010
    ..We will use the bacterial potassium channel, KVAP, which can be produced in large quantities in bacterial culture, purified and reconstituted into ..
  56. Ameliorating Sickle Nephropathy and Pulmonary Hypertension
    Punam Malik; Fiscal Year: 2013
    ..glomerular filtration rate (GFR), supranormal proximal tubular function and impaired ability to excrete potassium. Also seen is hematuria (gross or microscopic) from medullary tubulo-interstitial damage...
  57. Sex Hormones and Cardiac Arrhythmia in Transgenic LQT2 Rabbits
    Gideon Koren; Fiscal Year: 2012
    ..or sex hormone related differences in the expression of genes coding for the or subunits of the repolarizing potassium currents, calcium currents, and proteins that control Ca++ cycling, and the adrenergic receptors with the use of ..
  58. 2-pore-domain K+ channels as novel targets for modulating islet hormone secretion
    DAVID AARON JACOBSON; Fiscal Year: 2013
    ..regulate excitability are key regulators of Ca2+ influx, there is a gap in our understanding of the background potassium currents that stabilize the [unreadable]?p from where action potentials fire during glucose stimulation...
  59. MODULATION OF OLFACTORY BULB NEURON CURRENT PROPERTIES
    Debra Ann Fadool; Fiscal Year: 2013
    ..3 channel protein and the melanocortin 4 receptor will provide mechanistic details of how this potassium channel regulates energy homeostasis that modulates olfactory sensory ability via glucose utilization...
  60. Control of KATP channel expression by CaMKII: role in heart failure resistance
    DENICE HODGSON-ZINGMAN; Fiscal Year: 2013
    ..The ATP-sensitive potassium (KATP) channel, one of the most abundant cardiac membrane protein complexes, has the unique ability to adjust ..
  61. Functional immuno-imaging of lymphocyte motility and cell interactions in lymph n
    Michael D Cahalan; Fiscal Year: 2013
    ..The second goal is to investigate immunosuppression mediated by blockade of specific ion channels in T lymphocytes - a potassium channel Kv1.3 and a calcium channel Orai1 - for treatment of autoimmune disorders.
  62. Family-Based Genome-wide Association Study for Salt-Sensitivity of Blood Pressure
    Jiang He; Fiscal Year: 2011
    ..3 mmol/day), a 7-day high-sodium feeding (307.8 mmol/day), and a 7-day high- sodium feeding with an oral potassium supplementation (60 mmol/day) was conducted among 1,906 probands and their sibs, spouses, and offspring...
  63. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2007
    Cytosolic Regulation of Inner Ear Ion Transport Defects in potassium cycling, gap junction-mediated intercellular communication and cochlear metabolism are re- sponsible for the ovelwhelming majority of hearing impairments This proposal ..
  64. POLYUNSATURATES AND KC1 TO CONTROL MILD HYPERTENSION
    Frank Sacks; Fiscal Year: 1991
    ..of dietary polyunsaturated fatty acids in fish, oil, and of dietary magnesium, alone and with supplemental potassium. 1...
  65. Sodium and Cardiovascular Disease in Patients with Chronic Kidney Disease
    Jiang He; Fiscal Year: 2010
    ..The few prospective epidemiologic studies that examined the relationship between dietary sodium and potassium intake and risk of CVD provided contradictory findings...
  66. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 2003
    ..The hypotheses to be tested are: (1) exp-2 encodes a subunit of a negative spike potassium channel necessary for the fast repolarization of pharyngeal muscle...
  67. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
    ..High lead correlated with expression of particular potassium and calcium ion channel isofomis, with poor sperm-fertilization-potential biomarkers and low fertility by IVF, ..
  68. Enhanced Drug Delivery to Metastatic Brain Tumors
    Keith Black; Fiscal Year: 2006
    ..We have demonstrated that calcium-sensitive potassium (KCa) channel agonists selectively increase drug delivery across the BTB, and have postulated the biochemical ..
  69. PATCH CLAMP STUDY OF GASTROINTESTINAL NEURONS
    JACKIE WOOD; Fiscal Year: 1999
    ..at rest; 2) voltage activation of high threshold N-type calcium channels; 3) conduction in calcium-activated potassium channels; 4) voltage activation of A-type and delayed rectifier potassium channels...
  70. CITRIC ACID CYCLE METABOLISM DURING CARDIAC SURGERY
    Michael Jessen; Fiscal Year: 2001
    ..of cardioplegia will be studied, first in control hearts and then in hearts administered 1) warm continuous potassium cardioplegia, 2) an intracellular based cardioplegic solution, 3) low sodium and low potassium cardioplegia, 4) ..
  71. Role of glycosylation in voltage-gated potassium channels
    Desiree A Thayer; Fiscal Year: 2010
    b>Potassium channels are key components for the electrical properties of excitable cells, and voltage-gated potassium channels (Kv) control neuronal excitability...
  72. SODIUM IMAGING IN ISCHEMIC HEART DISEASE
    PAUL BOTTOMLEY; Fiscal Year: 2002
    The exchange of intra- and extra-cellular sodium and potassium ions is essential to cell function and integrity...
  73. GENETIC STUDIES OF THE SYNAPSE
    Lily Jan; Fiscal Year: 2000
    b>Potassium channels are a large and diverse group of ion channels found in most eukaryotic cells. They control the electrical potential across the cell membrane and the excitability of nerve and muscle cells...
  74. Mechanisms of regulation of excitability in immature CNS
    Joaquin N Lugo; Fiscal Year: 2010
    ..In adult brain potassium channels are major determinants of membrane excitability in neurons. One particular potassium channel, Kv4...
  75. DEVELOPMENT OF THE XENOPUS ACOUSTICO-VESTIBULAR SYSTEM
    ELBA SERRANO; Fiscal Year: 2002
    ..The potassium channels of the inner ear will be a central subject of these investigations, and will be used to test hypotheses ..