lithium

Summary

Summary: Lithium. An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight 6.94. Salts of lithium are used in treating manic-depressive disorders.

Top Publications

  1. ncbi GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides
    Christopher J Phiel
    Department of Medicine, Division of Hematology Oncology and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Philadelphia 19104 6148, USA
    Nature 423:435-9. 2003
  2. pmc Lithium induces autophagy by inhibiting inositol monophosphatase
    Sovan Sarkar
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, England, UK
    J Cell Biol 170:1101-11. 2005
  3. ncbi Metal oxide hollow nanostructures for lithium-ion batteries
    Zhiyu Wang
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore
    Adv Mater 24:1903-11. 2012
  4. ncbi Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus
    Kai Hu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Neurosci Lett 488:252-7. 2011
  5. doi Building better batteries
    M Armand
    LRCS, CNRS UMR 6007, Universite de Picardie Jules Verne, Amiens, France
    Nature 451:652-7. 2008
  6. pmc Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
    Wendy Noble
    Center for Dementia Research, Nathan S Kline Institute, New York University, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Proc Natl Acad Sci U S A 102:6990-5. 2005
  7. pmc Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells
    Quan Wang
    State Key Laboratory of Drug Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    Cell Res 21:1424-35. 2011
  8. pmc Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
    Jean Martin Beaulieu
    Howard Hughes Medical Institute, Department of Cell Biology and Center for Models of Human Disease, Institute of Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 101:5099-104. 2004
  9. ncbi Graphene-wrapped sulfur particles as a rechargeable lithium-sulfur battery cathode material with high capacity and cycling stability
    Hailiang Wang
    Department of Chemistry, Stanford University, Stanford, California 94305, United States
    Nano Lett 11:2644-7. 2011
  10. pmc Porous iron oxide ribbons grown on graphene for high-performance lithium storage
    Shubin Yang
    Max Planck Institute for Polymer Research, Ackermannweg 10, D 55128 Mainz, Germany
    Sci Rep 2:427. 2012

Detail Information

Publications361 found, 100 shown here

  1. ncbi GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides
    Christopher J Phiel
    Department of Medicine, Division of Hematology Oncology and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Philadelphia 19104 6148, USA
    Nature 423:435-9. 2003
    ..Here we show that therapeutic concentrations of lithium, a GSK-3 inhibitor, block the production of Abeta peptides by interfering with APP cleavage at the gamma-..
  2. pmc Lithium induces autophagy by inhibiting inositol monophosphatase
    Sovan Sarkar
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, England, UK
    J Cell Biol 170:1101-11. 2005
    ..Here we describe a novel mTOR-independent pathway that regulates autophagy. We show that lithium induces autophagy, and thereby, enhances the clearance of autophagy substrates, like mutant huntingtin and alpha-..
  3. ncbi Metal oxide hollow nanostructures for lithium-ion batteries
    Zhiyu Wang
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore
    Adv Mater 24:1903-11. 2012
    ..As electrode materials for lithium-ion batteries (LIBs), metal oxide hollow structures provide high specific capacity, superior rate capability, and ..
  4. ncbi Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus
    Kai Hu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Neurosci Lett 488:252-7. 2011
    ....
  5. doi Building better batteries
    M Armand
    LRCS, CNRS UMR 6007, Universite de Picardie Jules Verne, Amiens, France
    Nature 451:652-7. 2008
  6. pmc Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
    Wendy Noble
    Center for Dementia Research, Nathan S Kline Institute, New York University, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Proc Natl Acad Sci U S A 102:6990-5. 2005
    ..mice overexpressing mutant human tau were treated with the glycogen synthase kinase-3 (GSK-3) inhibitor lithium chloride. Treatment resulted in significant inhibition of GSK-3 activity...
  7. pmc Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells
    Quan Wang
    State Key Laboratory of Drug Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    Cell Res 21:1424-35. 2011
    ..Here we report that Lithium (Li), a drug used to treat mood disorders, greatly enhances iPSC generation from both mouse embryonic fibroblast ..
  8. pmc Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
    Jean Martin Beaulieu
    Howard Hughes Medical Institute, Department of Cell Biology and Center for Models of Human Disease, Institute of Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 101:5099-104. 2004
    ..Administration of lithium salts is known to inhibit DA-associated behaviors in experimental animal models through unknown mechanisms...
  9. ncbi Graphene-wrapped sulfur particles as a rechargeable lithium-sulfur battery cathode material with high capacity and cycling stability
    Hailiang Wang
    Department of Chemistry, Stanford University, Stanford, California 94305, United States
    Nano Lett 11:2644-7. 2011
    ..The resulting graphene-sulfur composite showed high and stable specific capacities up to ∼600 mAh/g over more than 100 cycles, representing a promising cathode material for rechargeable lithium batteries with high energy density.
  10. pmc Porous iron oxide ribbons grown on graphene for high-performance lithium storage
    Shubin Yang
    Max Planck Institute for Polymer Research, Ackermannweg 10, D 55128 Mainz, Germany
    Sci Rep 2:427. 2012
    ..of transition metal oxides has been regarded as a key to solve their problems of large volume changes during lithium insertion-desertion processes which are associated with pulverization of the electrodes and rapid capacity decay...
  11. ncbi Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish
    S E Stachel
    Department of Human Genetics, University of Utah, Salt Lake City 84112
    Development 117:1261-74. 1993
    ..First, we show that brief exposure of premidblastula embryos to lithium, which is known to shut down the phospho-inositol signaling pathway, produces excessive shield formation and ..
  12. ncbi Lithium toxicity profile: a systematic review and meta-analysis
    Rebecca F McKnight
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Lancet 379:721-8. 2012
    b>Lithium is a widely used and effective treatment for mood disorders. There has been concern about its safety but no adequate synthesis of the evidence for adverse effects...
  13. pmc A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response
    Michael J McCarthy
    Veterans Affairs San Diego Healthcare System, San Diego, California, United Sates of America
    PLoS ONE 7:e32091. 2012
    ..Then we compared the results to a set of lithium-responsive genes...
  14. doi High-performance lithium battery anodes using silicon nanowires
    Candace K Chan
    Nat Nanotechnol 3:31-5. 2008
    There is great interest in developing rechargeable lithium batteries with higher energy capacity and longer cycle life for applications in portable electronic devices, electric vehicles and implantable medical devices...
  15. ncbi Interconnected silicon hollow nanospheres for lithium-ion battery anodes with long cycle life
    Yan Yao
    Department of Materials Science and Engineering, Stanford University, Stanford, California 94305, United States
    Nano Lett 11:2949-54. 2011
    Silicon is a promising candidate for the anode material in lithium-ion batteries due to its high theoretical specific capacity...
  16. ncbi Lithium: still a major option in the management of bipolar disorder
    Rasmus W Licht
    Mood Disorders Research Unit, Aarhus University Hospital, Risskov, Risskov, Denmark
    CNS Neurosci Ther 18:219-26. 2012
    Still after more than 50 years, lithium is a major treatment of bipolar disorder, even though it has not been promoted by the pharmaceutical industry over the last decades...
  17. ncbi Renal failure occurs in chronic lithium treatment but is uncommon
    Hans Bendz
    Department of Psychiatry, Lund University Hospital, Lund, Sweden
    Kidney Int 77:219-24. 2010
    We sought to establish the prevalence of lithium-induced end-stage renal disease in two regions of Sweden with 2.7 million inhabitants corresponding to about 30% of the Swedish population...
  18. ncbi Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies
    Hanae Nakashima
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 700 8558, Okayama, Japan
    Acta Neuropathol 110:547-56. 2005
    b>Lithium, a widely used drug for treating affective disorders, is known to inhibit glycogen synthase kinase-3 (GSK-3), which is one of the major tau kinases...
  19. ncbi Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy
    Andreas Heiseke
    Institute of Virology, Technische Universitat Munchen, Munich, Germany
    J Neurochem 109:25-34. 2009
    b>Lithium is used for several decades to treat manic-depressive illness (bipolar affective disorder)...
  20. ncbi Virus-enabled synthesis and assembly of nanowires for lithium ion battery electrodes
    Ki Tae Nam
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 312:885-8. 2006
    ..shown excellent electrochemical cycling properties and is thus under consideration as an electrode for advanced lithium batteries. We used viruses to synthesize and assemble nanowires of cobalt oxide at room temperature...
  21. ncbi Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition
    Yan Leng
    Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1363, USA
    J Neurosci 28:2576-88. 2008
    b>Lithium and valproic acid (VPA) are two primary drugs used to treat bipolar mood disorder and have frequently been used in combination to treat bipolar patients resistant to monotherapy with either drug...
  22. ncbi Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3
    Fang Zhang
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 278:33067-77. 2003
    Glycogen synthase kinase-3 (GSK-3) is a critical, negative regulator of diverse signaling pathways. Lithium is a direct inhibitor of GSK-3 and has been widely used to test the putative role of GSK-3 in multiple settings...
  23. ncbi Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation
    E M Wexler
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA 90024 1759, USA
    Mol Psychiatry 13:285-92. 2008
    ..We demonstrate that the mood stabilizer lithium directly expands pools of AHPs in vitro, and induces them to become neurons at therapeutically relevant ..
  24. ncbi Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert
    Tobias Engel
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Madrid, Spain
    J Neurochem 99:1445-55. 2006
    ..b>Lithium, a widely used drug for affective disorders, inhibits GSK-3 at therapeutically relevant concentrations...
  25. ncbi Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing
    Yuan Su
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Biochemistry 43:6899-908. 2004
    b>Lithium is one of the most widely used mood-stabilizing agents for the treatment of bipolar disorder...
  26. ncbi Pharmacogenetics of lithium response in bipolar disorder
    Michael J McCarthy
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Pharmacogenomics 11:1439-65. 2010
    Bipolar disorder (BD) is a serious mental illness with well-established, but poorly characterized genetic risk. Lithium is among the best proven mood stabilizer therapies for BD, but treatment responses vary considerably...
  27. ncbi A common mechanism of action for three mood-stabilizing drugs
    Robin S B Williams
    Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
    Nature 417:292-5. 2002
    b>Lithium, carbamazepine and valproic acid are effective mood-stabilizing treatments for bipolar affective disorder. The molecular mechanisms underlying the actions of these drugs and the illness itself are unknown...
  28. pmc Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease
    Chi Tso Chiu
    Section on Molecular Neurobiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
    Neuropsychopharmacology 36:2406-21. 2011
    Emerging evidence suggests that the mood stabilizers lithium and valproate (VPA) have broad neuroprotective and neurotrophic properties, and that these occur via inhibition of glycogen synthase kinase 3 (GSK-3) and histone deacetylases (..
  29. ncbi Excellent lithium responders have normal cognitive functions and plasma BDNF levels
    Janusz K Rybakowski
    Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
    Int J Neuropsychopharmacol 13:617-22. 2010
    In bipolar patients, neuropsychological and biochemical disturbances persist into the remission period. Excellent lithium responders (ELRs) comprise around one third of lithium-treated patients and have total remission of recurrences on ..
  30. ncbi Graphene anchored with co(3)o(4) nanoparticles as anode of lithium ion batteries with enhanced reversible capacity and cyclic performance
    Zhong Shuai Wu
    Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, People s Republic of China
    ACS Nano 4:3187-94. 2010
    ..of Co(3)O(4) nanoparticles anchored on conducting graphene as an advanced anode material for high-performance lithium-ion batteries...
  31. ncbi Formation of Fe2O3 microboxes with hierarchical shell structures from metal-organic frameworks and their lithium storage properties
    Lei Zhang
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore
    J Am Chem Soc 134:17388-91. 2012
    ..When evaluated as an anode material for lithium ion batteries, the Fe(2)O(3) microboxes with a well-defined hollow structure and hierarchical shell manifested ..
  32. ncbi Synthesis of a metallic mesoporous pyrochlore as a catalyst for lithium–O2 batteries
    Si Hyoung Oh
    University of Waterloo, Department of Chemistry, Waterloo, Ontario, Canada N2L 3G1
    Nat Chem 4:1004-10. 2012
    The lithium–O2 ‘semi-fuel’ cell based on the reversible reaction of Li and O2 to form Li2O2 can theoretically provide energy densities that exceed those of Li-ion cells by up to a factor of five...
  33. pmc CoMn(2)O(4) spinel hierarchical microspheres assembled with porous nanosheets as stable anodes for lithium-ion batteries
    Lin Hu
    Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, 230026, PR China
    Sci Rep 2:986. 2012
    ..As a result, CoMn(2)O(4) hierarchical microspheres can achieve a good cycle ability and high rate capability...
  34. ncbi Hierarchical three-dimensional ZnCo₂O₄ nanowire arrays/carbon cloth anodes for a novel class of high-performance flexible lithium-ion batteries
    Bin Liu
    Wuhan National Laboratory for Optoelectronics and College of Optoelectronic Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
    Nano Lett 12:3005-11. 2012
    ..Highly flexible full batteries were also fabricated, exhibiting high flexibility, excellent electrical stability, and superior electrochemical performances...
  35. ncbi Platinum-gold nanoparticles: a highly active bifunctional electrocatalyst for rechargeable lithium-air batteries
    Yi Chun Lu
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 132:12170-1. 2010
    ..It is hypothesized that PtAu NPs exhibit bifunctional catalytic activity, having surface Au and Pt atoms primarily responsible for ORR and OER kinetics in Li-O(2) cells, respectively...
  36. ncbi Lithium reduced neural progenitor apoptosis in the hippocampus and ameliorated functional deficits after irradiation to the immature mouse brain
    Kaiming Huo
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden
    Mol Cell Neurosci 51:32-42. 2012
    b>Lithium was recently shown to inhibit apoptosis and promote survival of neural progenitor cells after hypoxia-ischemia in the immature rat brain...
  37. ncbi Lithium-induced nephropathy: Rate of progression and prognostic factors
    Claire Presne
    AP HP, Hopital Necker, Service de Néphrologie et Université Paris V, Paris, France
    Kidney Int 64:585-92. 2003
    Long-term lithium administration in humans may lead to chronic tubulointerstitial nephritis, which develops very slowly. Its progression to end-stage renal disease (ESRD) has been rarely reported...
  38. ncbi Lithium use and the risk of fractures
    Ingeborg Wilting
    Utrecht University, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht, The Netherlands
    Bone 40:1252-8. 2007
    A recent study reported a decreased risk of fractures among lithium users...
  39. pmc Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia
    Q Li
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Cell Death Dis 1:e56. 2010
    b>Lithium is used in the treatment of bipolar mood disorder. Reportedly, lithium can be neuroprotective in models of adult brain ischemia...
  40. ncbi Electronically conductive phospho-olivines as lithium storage electrodes
    Sung Yoon Chung
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Mater 1:123-8. 2002
    b>Lithium transition metal phosphates have become of great interest as storage cathodes for rechargeable lithium batteries because of their high energy density, low raw materials cost, environmental friendliness and safety...
  41. ncbi Synthesis of nitrogen-doped graphene films for lithium battery application
    Arava Leela Mohana Reddy
    Department of Mechanical Engineering and Materials Science, Rice University, Houston, Texas 77005, United States
    ACS Nano 4:6337-42. 2010
    ..Direct growth of active electrode material on current collector substrates makes this a feasible and efficient process for integration into current battery manufacture technology...
  42. ncbi A randomized, double-blind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Clin Psychiatry 66:111-21. 2005
    ..To evaluate the efficacy and tolerability of quetiapine monotherapy versus placebo for the treatment of mania associated with bipolar disorder...
  43. ncbi Lithium and dementia: a preliminary study
    Takeshi Terao
    Department of Neuropsychiatry, Oita University Faculty of Medicine, Oita, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1125-8. 2006
    Recent studies have shown that lithium may block the accumulation of amyloid-beta (Abeta) peptides and to inhibit the hyperphosphorylation of tau via the inhibition of GSK-3alpha in the brain of mice...
  44. ncbi Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    K P Hoeflich
    Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Nature 406:86-90. 2000
    ..b>Lithium treatment (which inhibits GSK-3; refs 8, 9) sensitized wild-type fibroblasts to TNF and inhibited transactivation ..
  45. pmc Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
    Chi Tso Chiu
    Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive MSC 1363, Bethesda, MD 20892 1363, USA
    Pharmacol Ther 128:281-304. 2010
    b>Lithium has been used clinically to treat bipolar disorder for over half a century, and remains a fundamental pharmacological therapy for patients with this illness...
  46. ncbi Lithium and valproic acid: parallels and contrasts in diverse signaling contexts
    Nadia Gurvich
    Graduate Group in Pharmacological Sciences, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacol Ther 96:45-66. 2002
    The introduction of lithium salts to treat bipolar disorder (BPD) revolutionized the therapy of psychiatric illnesses, but the pathogenesis of the disease and the mechanism of lithium action remain unknown...
  47. pmc CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium
    C A Grimes
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0017, USA
    J Neurochem 78:1219-32. 2001
    The regulatory influences of glycogen synthase kinase-3 beta (GSK3 beta) and lithium on the activity of cyclic AMP response element binding protein (CREB) were examined in human neuroblastoma SH-SY5Y cells...
  48. ncbi Fabricating genetically engineered high-power lithium-ion batteries using multiple virus genes
    Yun Jung Lee
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 324:1051-5. 2009
    ..For lithium-ion (Li+) batteries, reducing material dimensions can boost Li+ ion and electron transfer in nanostructured ..
  49. ncbi Molecular targets of lithium action
    C J Phiel
    Department of Medicine and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA
    Annu Rev Pharmacol Toxicol 41:789-813. 2001
    b>Lithium is highly effective in the treatment of bipolar disorder and also has multiple effects on embryonic development, glycogen synthesis, hematopoiesis, and other processes. However, the mechanism of lithium action is still unclear...
  50. ncbi Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials
    Andrea Cipriani
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 162:1805-19. 2005
    Observational studies suggest that long-term lithium treatment has a strong antisuicidal effect in mood disorders, but it is uncertain whether this association is a genuine therapeutic effect or is due to confounding factors in ..
  51. ncbi Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo
    Jin Seuk Kim
    Department of Biochemistry, Hanyang University College of Medicine, Seoul, Korea
    J Neurochem 89:324-36. 2004
    b>Lithium has been demonstrated to increase neurogenesis in the dentate gyrus of rodent hippocampus...
  52. pmc Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice
    Anna Fiorentini
    Department of Pharmacology, University of Florence, Florence, Italy
    PLoS ONE 5:e14382. 2010
    ..Adult hippocampal neurogenesis plays an important role in learning and memory processes and its abnormal regulation might account for cognitive impairments associated with AD...
  53. ncbi The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
    G Chen
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurochem 72:879-82. 1999
    ..of mRNA was used to identify concordant changes in gene expression induced by two mood-stabilizing agents, lithium and valproate (VPA)...
  54. pmc E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:11614-9. 2010
    ..Bmal1 Rev-erb alpha protein degradation can be triggered by inhibitors of glycogen synthase kinase 3beta, such as lithium, and also by serum shock, which synchronizes circadian rhythms in cultured cells...
  55. ncbi Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells
    C D Mao
    Department of Cell Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 276:26180-8. 2001
    b>Lithium affects development of various organisms and cell fate through the inhibition of glycogen synthase kinase-3 beta and induction of the Wnt/beta-catenin signaling pathway...
  56. ncbi High-level exposure to lithium, boron, cesium, and arsenic via drinking water in the Andes of northern Argentina
    Gabriela Concha
    Division of Toxicology, Swedish National Food Administration, Box 622, S 751 26 Uppsala, Sweden
    Environ Sci Technol 44:6875-80. 2010
    ..arsenic concentrations in the drinking water (up to 210 microg/L), we found remarkably high concentrations of lithium (highest 1000 microg/L), cesium (320 microg/L), rubidium (47 microg/L), and boron (5950 microg/L)...
  57. pmc The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells
    Jason S King
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK
    Dis Model Mech 2:306-12. 2009
    ..b>Lithium and other mood stabilisers deplete intracellular inositol and it has been proposed that bipolar mood disorder ..
  58. pmc A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta
    Tsuyoshi Hirota
    Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:20746-51. 2008
    ..3 (GSK-3) consistently caused a strong short period phenotype in contrast to the well-known period lengthening by lithium, another presumed GSK-3 inhibitor...
  59. ncbi In situ TEM study of lithiation behavior of silicon nanoparticles attached to and embedded in a carbon matrix
    Meng Gu
    Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, United States
    ACS Nano 6:8439-47. 2012
    ..be a feasible way for mitigating the capacity fading associated with the large volume change of silicon anode in lithium ion batteries...
  60. ncbi Raising the cycling stability of aqueous lithium-ion batteries by eliminating oxygen in the electrolyte
    Jia Yan Luo
    Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of New Energy, Fudan University, Shanghai 200433, China
    Nat Chem 2:760-5. 2010
    Aqueous lithium-ion batteries may solve the safety problem associated with lithium-ion batteries that use highly toxic and flammable organic solvents, and the poor cycling life associated with commercialized aqueous rechargeable ..
  61. ncbi NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease
    Mahmoud A Pouladi
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, and Child and Family Research Institute, Vancouver, BC, Canada
    Neurobiol Dis 48:282-9. 2012
    ..b>Lithium, a drug widely used for the treatment of bipolar disorder, has been shown to exert neuroprotective effects in a ..
  62. ncbi Oxygen bridges between NiO nanosheets and graphene for improvement of lithium storage
    Guangmin Zhou
    Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China
    ACS Nano 6:3214-23. 2012
    ..We believe that the understanding of this oxygen bridge between graphene and NiO will lead to the development of other high-performance electrode materials...
  63. ncbi Renewable and superior thermal-resistant cellulose-based composite nonwoven as lithium-ion battery separator
    Jianjun Zhang
    Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, P R China
    ACS Appl Mater Interfaces 5:128-34. 2013
    A renewable and superior thermal-resistant cellulose-based composite nonwoven was explored as lithium-ion battery separator via an electrospinning technique followed by a dip-coating process...
  64. pmc The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane
    J Wieland
    Institut für Biochemie der Universität Stuttgart, Germany
    EMBO J 14:3870-82. 1995
    ..Finally, we show that the Na+ tolerance mediated through these pumps is regulated by calmodulin via a calcineurin-independent mechanism which activates the Pmr2 ion pumps post-transcriptionally...
  65. pmc NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy
    Raquel Gómez-Sintes
    Centro de Biologia Molecular Severo Ochoa CBM SO, CSIC UAM, 28049 Madrid, Spain
    J Clin Invest 120:2432-45. 2010
    Use of lithium, the mainstay for treatment of bipolar disorder, is limited by its frequent neurological side effects and its risk for overdose-induced toxicity...
  66. ncbi Opposed effects of lithium on the MEK-ERK pathway in neural cells: inhibition in astrocytes and stimulation in neurons by GSK3 independent mechanisms
    Raul Pardo
    Institut de Neurosciènces and Departament de Bioquímica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurochem 87:417-26. 2003
    b>Lithium is widely used in the treatment of bipolar disorder, but despite its proven therapeutic efficacy, the molecular mechanisms of action are not fully understood...
  67. ncbi An improved high-performance lithium-air battery
    Hun Gi Jung
    Department of WCU Energy Engineering, Hanyang University, Seoul 133 791, Republic of Korea
    Nat Chem 4:579-85. 2012
    ..the consumer electronics markets as the power source of choice for popular portable devices, the common lithium battery is not yet suited for use in sustainable electrified road transport...
  68. pmc Lithium rescues synaptic plasticity and memory in Down syndrome mice
    Andrea Contestabile
    Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy
    J Clin Invest 123:348-61. 2013
    ..We report that, in the Ts65Dn mouse model of DS, chronic administration of lithium, a clinically used mood stabilizer, promoted the proliferation of neuronal precursor cells through the ..
  69. ncbi Spindle-like mesoporous α-Fe₂O₃ anode material prepared from MOF template for high-rate lithium batteries
    Xiaodong Xu
    Interdisciplinary School of Green Energy, Ulsan National Institute of Science and Technology UNIST, Ulsan 689 798, Korea
    Nano Lett 12:4988-91. 2012
    ..When tested as anode material for lithium batteries (LBs), this spindle-like porous α-Fe(2)O(3) shows greatly enhanced performance of Li storage...
  70. ncbi Evaluation of the Becton-Dickinson rapid serum tube: does it provide a suitable alternative to lithium heparin plasma tubes?
    Goce Dimeski
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
    Clin Chem Lab Med 48:651-7. 2010
    ..Although lithium heparin plasma has unique problems, it has become an alternative in hospital-based laboratories.
  71. ncbi Synthesis of phosphorus-doped graphene and its multifunctional applications for oxygen reduction reaction and lithium ion batteries
    Chenzhen Zhang
    Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China
    Adv Mater 25:4932-7. 2013
    ..activity towards the oxygen reduction reaction and enhances the electrochemical performance as an anode material for lithium ion batteries. The experimental results suggest the significant role of phosphorus atoms in graphene.
  72. ncbi Top-down fabrication of α-Fe2O3 single-crystal nanodiscs and microparticles with tunable porosity for largely improved lithium storage properties
    Jun Song Chen
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, China
    J Am Chem Soc 132:13162-4. 2010
    ..a much larger total pore volume and average pore size compared to the pristine ones, thus serving as the possible origin for their greatly enhanced capacity retention when tested as potential anode materials for lithium-ion batteries.
  73. ncbi Effects of lithium therapy on Na+-K+-ATPase activity and lipid peroxidation in bipolar disorder
    Ushasi Banerjee
    Department of Biochemistry, Burdwan Medical College and Hospital, Burdwan, 713104, West Bengal, India
    Prog Neuropsychopharmacol Biol Psychiatry 37:56-61. 2012
    ..Although, lithium therapy results in significant improvement in the symptoms of the disease, studies regarding its effect on the ..
  74. ncbi Effects of lithium on lipopolysaccharide-induced inflammation in rat primary glia cells
    Sigalit Nahman
    Department of Clinical Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Innate Immun 18:447-58. 2012
    b>Lithium is the gold-standard treatment for bipolar disorder, a severe mental illness...
  75. pmc Lithium regulates keratinocyte proliferation via glycogen synthase kinase 3 and NFAT2 (nuclear factor of activated T cells 2)
    Philip J Hampton
    Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Cell Physiol 227:1529-37. 2012
    Certain environmental factors including drugs exacerbate or precipitate psoriasis. Lithium is the commonest cause of drug-induced psoriasis but underlying mechanisms are currently unknown...
  76. ncbi MoS₂ nanoplates consisting of disordered graphene-like layers for high rate lithium battery anode materials
    Haesuk Hwang
    Interdisciplinary School of Green Energy, Ulsan National Institute of Science and Technology UNIST, Ulsan 689 798, Korea
    Nano Lett 11:4826-30. 2011
    ..1 A/g) rate, showing a reversible capacity of 700 mAh/g. In addition, a full cell (LiCoO(2)/MoS(2)) test result also demonstrates excellent capacity retention up to 60 cycles...
  77. ncbi Engineering empty space between Si nanoparticles for lithium-ion battery anodes
    Hui Wu
    Department of Materials Science and Engineering Stanford University, California 94305, USA
    Nano Lett 12:904-9. 2012
    Silicon is a promising high-capacity anode material for lithium-ion batteries yet attaining long cycle life remains a significant challenge due to pulverization of the silicon and unstable solid-electrolyte interphase (SEI) formation ..
  78. ncbi Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U405, Faculty of Medicine, Strasbourg, France
    Neurobiol Dis 17:385-402. 2004
    ..Factor-kappaB (NF-kappaB), and Cyclooxygenase-2 (COX-2) expression together with neurodegeneration in the rat lithium-pilocarpine model...
  79. pmc Neuroprotective action of lithium in disorders of the central nervous system
    Chi Tso Chiu
    Section on Molecular Neurobiology, National Institute of Mental Health, National Institutes of Health, 10 Center Drive MSC 1363, Bethesda, MD 20892 1363, USA
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:461-76. 2011
    Substantial in vitro and in vivo evidence of neurotrophic and neuroprotective effects of lithium suggests that it may also have considerable potential for the treatment of neurodegenerative conditions...
  80. ncbi Formation of ZnMn2O4 ball-in-ball hollow microspheres as a high-performance anode for lithium-ion batteries
    Genqiang Zhang
    TUM CREATE Centre for Electromobility, Singapore
    Adv Mater 24:4609-13. 2012
    ..When evaluated as an anode material for lithium-ion batteries, these ZnMn(2)O(4) ball-in-ball hollow microspheres show significantly enhanced electrochemical ..
  81. pmc Effects of lithium on oxidative stress parameters in healthy subjects
    Rushaniya Khairova
    Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Med Rep 5:680-2. 2012
    ..b>Lithium has been shown to prevent and/or reverse DNA damage, free-radical formation and lipid peroxidation in diverse ..
  82. ncbi Quasiemulsion-templated formation of α-Fe2O3 hollow spheres with enhanced lithium storage properties
    Bao Wang
    School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457
    J Am Chem Soc 133:17146-8. 2011
    ..When tested as anode materials for lithium-ion batteries, these α-Fe(2)O(3) hollow spheres manifest greatly enhanced Li storage properties.
  83. pmc Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3alpha/beta impairs in vivo neural precursor cell proliferation
    Tae Yeon Eom
    Department of Psychiatry, Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Biol Psychiatry 66:494-502. 2009
    ..Because these diseases might be associated with inadequately controlled glycogen synthase kinase-3 (GSK3), we tested whether blocked inhibitory serine-phosphorylation of GSK3 impairs neurogenesis...
  84. pmc The balance of TCF7L2 variants with differential activities in Wnt-signaling is regulated by lithium in a GSK3beta-independent manner
    Ian Struewing
    Department of Clinical Sciences, University of Kentucky, Lexington, KY, USA
    Biochem Biophys Res Commun 399:245-50. 2010
    ..b>Lithium, a Wnt-signaling activator, increases TCF7L2 mRNA levels and induces an RNA isoform switch favoring the ..
  85. ncbi A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats
    Julien Detour
    INSERM U398, Faculty of Medicine, Strasbourg, France
    Epilepsia 46:499-508. 2005
    In temporal lobe epilepsy (TLE), interictal behavioral disorders affect patients' quality of life. Therefore we studied long-term behavioral impairments in the lithium-pilocarpine (li-pilo) model of TLE.
  86. ncbi Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms
    Sergei Y Noskov
    Institute for Biocomplexity and Informatics, Department for Biological Sciences, University of Calgary, 2500 University Drive, Calgary, AB, Canada
    J Mol Biol 377:804-18. 2008
    ....
  87. ncbi Activation of the Wnt signaling pathway: a molecular mechanism for lithium action
    C M Hedgepeth
    Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia 19104 6148, USA
    Dev Biol 185:82-91. 1997
    ..We now provide evidence that lithium activates downstream components of the wnt signaling pathway in vivo, leading to accumulation of beta-catenin ..
  88. ncbi The mechanism of lithium action: state of the art, ten years later
    A Shaldubina
    Stanley Center for Bipolar Research, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheba, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 25:855-66. 2001
    b>Lithium is an effective drug for both treatment and prophylaxis of bipolar disorder. However, the mechanism of lithium action is still unknown...
  89. ncbi WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons
    F R Lucas
    Developmental Biology Research Centre, The Randall Institute, King s College London, 26 29 Drury Lane, London, WC2B 5RL, United Kingdom
    Dev Biol 192:31-44. 1997
    ..b>Lithium mimics WNT-7a in granule cells by inhibiting GSK-3beta, a component of the WNT signaling pathway...
  90. ncbi Long-term outcome of lithium prophylaxis in bipolar disorder: a 5-year prospective study of 402 patients at a lithium clinic
    M Maj
    Department of Psychiatry, First Medical School, University of Naples, Italy
    Am J Psychiatry 155:30-5. 1998
    In this prospective study, information was collected on all bipolar I patients who started lithium prophylaxis at a lithium clinic during more than 15 years.
  91. ncbi Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases
    Akihiko Wada
    Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    J Pharmacol Sci 99:307-21. 2005
    In addition to the well-documented mood-stabilizing effects of lithium in manic-depressive illness patients, recent in vitro and in vivo studies in rodents and humans have increasingly implicated that lithium can be used in the treatment ..
  92. pmc Mania-like behavior induced by disruption of CLOCK
    Kole Roybal
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 104:6406-11. 2007
    ..Chronic administration of the mood stabilizer lithium returns many of these behavioral responses to wild-type levels...
  93. ncbi Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors
    Diviya Sinha
    Renal Section, Evans Biomedical Research Center, Rm 546, 650 Albany St, Boston, MA 02118, USA
    Am J Physiol Renal Physiol 288:F703-13. 2005
    ..The present study examines the hypothesis that lithium (Li(+)) and (2'Z,3'E)-6-bromoindirubin-3'-oxime (BIO), two glycogen synthase kinase-3beta (GSK3beta) inhibitors, ..
  94. pmc Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice
    W Timothy O'Brien
    Department of Medicine, Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:3756-62. 2011
    b>Lithium is the first-line therapy for bipolar disorder. However, its therapeutic target remains controversial...
  95. ncbi Review of lithium effects on brain and blood
    Wise Young
    W M Keck Center for Collaborative Neuroscience, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA
    Cell Transplant 18:951-75. 2009
    Clinicians have long used lithium to treat manic depression. They have also observed that lithium causes granulocytosis and lymphopenia while it enhances immunological activities of monocytes and lymphocytes...
  96. ncbi Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder?
    Stanley I Rapoport
    Brain Physiology and Metabolism Section, Bldg 10, Room 6N202, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:592-6. 2002
    b>Lithium and certain anticonvulsants, including carbamazepine and valproic acid, are effective antimanic drugs for treating bipolar disorder, but their mechanisms of action remain uncertain.
  97. ncbi Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation
    Ryota Hashimoto
    Section on Molecular Neurobiology, Mood and Anxiety Disorder Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1363, USA
    J Neurochem 80:589-97. 2002
    The therapeutic mechanisms of lithium for treating bipolar mood disorder remain poorly understood. Recent studies demonstrate that lithium has neuroprotective actions against a variety of insults...
  98. pmc Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing
    Yan Chen
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    PLoS Med 4:e249. 2007
    ..However, its role in bone repair is unknown. The goal of this study was to explore the role of beta-catenin signaling in bone repair...
  99. ncbi Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax
    Moussa B H Youdim
    Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Faculty of Medicine, Technion, Efron Street, P O Box 9697, Haifa 31096, Israel
    Neuropharmacology 46:1130-40. 2004
    b>Lithium has been reported to exert neuroprotective activity in several neuronal cell cultures and in vivo models against glutamate toxicity...
  100. ncbi Glucocorticoids and lithium reciprocally regulate the proliferation of adult dentate gyrus-derived neural precursor cells through GSK-3beta and beta-catenin/TCF pathway
    Shuken Boku
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neuropsychopharmacology 34:805-15. 2009
    ..On the other hand, the mood stabilizer lithium (Li) commonly used for their treatment increases it...
  101. ncbi Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Department of Neuropsychiatric Sciences, San Raffaele Turro, 20127 Milano, Italy
    Neurosci Lett 376:51-5. 2005
    ..GSK3-beta codes for an enzyme which is a target for the action of lithium and possibly of valproic acid...

Research Grants80

  1. OMEGA-3 FATTY ACIDS IN BIPOLAR DISORDER PROPHYLAXIS
    ANDREW STOLL; Fiscal Year: 2002
    ..acids), are polyunsaturated lipids which inhibit intracellular signal transduction in a manner comparable to lithium and divalproex, 2 drugs with efficacy in bipolar disorder...
  2. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
    ..b>Lithium has been the standard of treatment for BPD, but, because of its side effects, anti-convulsants (including ..
  3. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..In conditions of high tubular flow that occur with water loading or lithium ingestion, puringeric signaling and PGE2 production is augmented in CD epithelial isolated from these rodents, ..
  4. Cell stress, development, and stimulant-induced behavior: Regulation by GSK3
    Marjelo A Mines; Fiscal Year: 2012
    ..Furthermore, GSK3 is a feasible therapeutic target because the GSK3 inhibitor lithium is already widely used as a treatment for bipolar disorder and many new small molecule selective GSK3 inhibitors ..
  5. Role of Matrix Metalloproteinase-1 in Endothelial Cell Senescence
    Catherine D Mao; Fiscal Year: 2010
    ..b>Lithium is commonly used to treat bipolar disorder as well as to activate the oncogenic 2-catenin signaling pathway via ..
  6. Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human Neurons
    JEN PAN; Fiscal Year: 2013
    ..bipolar disorder suffer from recurrent episodes of mania and depression, and current bipolar treatments, such as lithium, are often ineffective in many patients...
  7. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
    ..Aim 3: To test anticonvulsant action of two classes of compounds in controlling lithium/pilocarpine and OP paraoxon-induced status epilepticus...
  8. Mediators of Lithium Action in Olfactory Epithelium
    Evaristus A Nwulia; Fiscal Year: 2013
    ..b>Lithium, used for treatment of BD, alters steady-state mRNA levels of a large number of genes;notably GSK-32, inositol ..
  9. Roles of Gs Alpha and interaction with Wnt signaling in regulation of adipocyte d
    Partha S Sinha; Fiscal Year: 2011
    ..This question will address by testing the effects of in utero lithium exposure on Osterix-Cre:Gsa fl/fl mice upon bone mass, bone marrow adiposity, and relative numbers of adipocyte ..
  10. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael L McDaniel; Fiscal Year: 2012
    ..The highly reproducible stimulation of mTOR-mediated DNA synthesis by lithium, a GSK-3 inhibitor, in human islets is remarkable since nutrients are rarely effective...
  11. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2012
    ..We found that mice pretreated with the GSK3 inhibitor lithium are completely protected from development of experimental autoimmune encephalomyelitis (EAE), a mouse model of MS,..
  12. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..address this issue experiments will be conducted to examine the effects of cisplatin (a chemotherapy agent) and lithium chloride (LiCI) (treatments that produce nausea in humans) on visceral afferent nerve activity and brain and ..
  13. Effect of Major Depression and antidepressants on human neurogenesis
    Maura Boldrini; Fiscal Year: 2013
    ..treated with selective serotonin reuptake inhibitors, SSRI, ten treated with tricyclic antidepressants, TCA) or lithium (n=6) at the time of death;2. MD patients (n=20) who were not on antidepressants for e 3 months and 3...
  14. The Role of HIF-1 in Neurogenic and Behavior Responses to Antidepressants.
    W TIMOTHY O'BRIEN; Fiscal Year: 2013
    ..We have forwarded the hypothesis that GSK-3 is the molecular target of lithium, a mood stabilizer, and modulates several antidepressant-sensitive behaviors...
  15. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2012
    ..In support of this hypothesis, our preliminary data show that: 1) lithium and other selective GSK3 inhibitors significantly increase the number of HSCs in mice, 2) RNAi mediated depletion ..
  16. Suicide Endophenotypes and Molecular Mechanisms of Lithium Action
    Todd D Gould; Fiscal Year: 2013
    ..Few treatments have been shown to reduce risk. An exception, supported by extensive clinical evidence, is that lithium is effective in reducing the risk of both attempted and completed suicide...
  17. Countermeasures for chlorine-induced airway fibrosis
    Gary W Hoyle; Fiscal Year: 2013
    ..or the plasminogen activator inhibitor-1 inhibitor tiplaxtinin;and manipulation of Wnt/ss-catenin signaling with lithium chlorie or pyrvinium...
  18. Pre-Clinical Development of a Fetal Micropacemaker
    Ramen Chmait; Fiscal Year: 2013
    ..The micropacemaker is powered by a tiny, commercially available, rechargeable lithium ion cell which can provide power for 2-3 weeks of pacing...
  19. Regulation of Renal Response to Vasopressin by Glycogen Synthase
    Reena Rao; Fiscal Year: 2013
    ..Despite in vitro and in vivo evidence that lithium, a common therapy for bipolar disorders and a potent inhibitor of GSK3[unreadable] can reduce renal response to ..
  20. Circadian Clock Genes in Bipolar Disorder
    MICHAEL JOSEPH MCCARTHY; Fiscal Year: 2013
    ..In responsive patients, lithium is an excellent treatment for BD, but many patients fail to respond and needlessly suffer side-effects or delays ..
  21. A Molecular Mechanism for Lithium Action
    Peter S Klein; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lithium is the first line of therapy in the treatment of bipolar disorder yet its mechanism of action in this setting is not known...
  22. Effects of lithium on cellular signaling
    Richard S Jope; Fiscal Year: 2011
    ..b>Lithium, the classical mood stabilizer used to treat bipolar disorder, inhibits glycogen synthase kinase-3 (GSK3) by a ..
  23. The Effect of Bipolar Disorder and its Comorbidities on Cognition in Older Adults
    ARIEL GERARD GILDENGERS; Fiscal Year: 2013
    ..As part of this investigation, we will examine the potential neuroprotective and/or neurotrophic effects of lithium and valproate that may moderate the expression of cognitive dysfunction and decline...
  24. Effects of lithium on cellular signaling
    Richard S Jope; Fiscal Year: 2013
    ..b>Lithium, the classical mood stabilizer used to treat bipolar disorder, inhibits GSK3 by a dual mechanism, directly ..
  25. Rational polytherapy in the treatment of cholinergic seizures
    Claude G Wasterlain; Fiscal Year: 2013
    ..such three-drug combinations can, with little depression of consciousness, stop seizures induced by high-dose lithium and pilocarpine and refractory to a profoundly anesthetic dose of benzodiazepine, the best 2- and 3-drug ..
  26. Metabolic regulators in the mechanisms of caloric restriction
    Rozalyn M Anderson; Fiscal Year: 2013
    ..We will determine the extent to which GSK32 inhibition (lithium carbonate), SIRT1 activation (resveratrol) or PGC-11 activation (bezafibrate) can mimic the effect of CR on i) ..
  27. Akt/GSK-3 Signaling Cascade and the Actions of Dopamine
    Marc G Caron; Fiscal Year: 2011
    ..drugs that bind D2Rs show a high propensity to engage the ?-arrestin 2-mediated pathway, and the mood stabilizer lithium interferes with this pathway by inhibiting the stability of the ?-arrestin 2/Akt/PP2A signaling complex...
  28. Akt/GSK-3 Signaling Cascade and the Actions of Dopamine
    Marc G Caron; Fiscal Year: 2013
    ..drugs that bind D2Rs show a high propensity to engage the ?-arrestin 2-mediated pathway, and the mood stabilizer lithium interferes with this pathway by inhibiting the stability of the ?-arrestin 2/Akt/PP2A signaling complex...
  29. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2013
    ..In support of this hypothesis, our preliminary data show that: 1) lithium and other selective GSK3 inhibitors significantly increase the number of HSCs in mice, 2) RNAi mediated depletion ..
  30. Mood-Stabilizing Medications and the Inositol Signaling System
    Ranga N Parthasarathy; Fiscal Year: 2013
    ..b>Lithium and valproate are the drugs of choice for the manic phase of BD...
  31. Therapeutic targeting of GSK3beta: A novel approach for podocyte protection
    Rujun Gong; Fiscal Year: 2013
    ..The efficacy of TDZD-8 will be compared with low dose lithium, a safe and effective FDA approved drug that possesses potent GSK3 inhibitory actions, already exists for decades ..
  32. Synaptic Phenotype, Development, and Plasticity in the Fragile X Mouse
    CHARLES LEROY COX; Fiscal Year: 2013
    ..proposed include AAV-virus mediated restoration of FMRP expression, as well as drug treatments including Lithium and specific metabotropic glutamate receptor antagonists...
  33. In vitro and in vivo study of simvastatin plus lithium in bipolar depression
    Roy H Perlis; Fiscal Year: 2013
    ..Work by our group and others strongly implicates Wnt/GSK3 signaling in the mechanism of action of lithium, which remains a first-line treatment for bipolar depression as well as prevention of recurrence...
  34. Studies of genes involved in the lithium responsive neurological processes
    Toshihiro Kitamoto; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although lithium displays remarkable mood-stabilizing properties and has served as one of the most effective therapies for bipolar disorder (BPD), the mechanisms underlying its actions on the nervous ..
  35. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2013
    ..In this proposal, we will explore the potential to utilize GSK3B inhibitors such as lithium to improve surgical outcomes for patient with metastatic MTC...
  36. Treatment of Status Epilepticus: A Translational Proposal
    Claude G Wasterlain; Fiscal Year: 2013
    ..We will induce SE chemically with lithium and pilocarpine, or electrically by stimulating the perforant path, and will treat at 3 time points: after the ..
  37. Single nucleotide polymorphisms of neuronal CACNA1C L-type calcium channels assoc
    Diane Lipscombe; Fiscal Year: 2011
    ..The most common treatment is lithium but this agent is only partially effective, has numerous side effects, and a low safety margin...
  38. Targeting Wnt and mTOR to expand hematopoietic stem cells
    Peter S Klein; Fiscal Year: 2012
    ..therapeutic strategy to expand HSCs in vivo and ex vivo using currently available FDA-approved agents, including lithium to inhibit GSK-3 and rapamycin/sirolimus to inhibit mTOR...
  39. Central Viscerosensory Circuits - Structure and Function
    LINDA M RINAMAN; Fiscal Year: 2013
    ..examine NA axonal collateralization and ascending pathway recruitment by a malaise- inducing agent, lithium chloride (LiCl)...
  40. White matter hypoxia in a novel model of MMP-mediated inflammation in SHR/SP
    GARY ALLEN ROSENBERG; Fiscal Year: 2013
    ..damage in chronically hypertensive rats by using electron paramagnetic resonance (EPR) to measure ptO2 with lithium phthalocyanine (LiPc) microcrystals implanted stereotactically into the corpus callosum, and to correlate the ..
  41. Calcium Study of Lymphoblasts in Bipolar Patients to Aid Diagnosis and Treatment
    CHARLES LEE BOWDEN; Fiscal Year: 2013
    ..in cell lines established from a blood sample predict the likelihood of response to the two mood stabilizers (lithium and quetiapine) being compared in the Bipolar CHOICE study...
  42. Potential Therapeutic Applications of Ecto-Nucleotidases in Lithium-induced NDI
    Bellamkonda K Kishore; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lithium (Li), an established treatment for bipolar disorders, is emerging as a potential neuroprotective therapy for acute and chronic neurodegenerative diseases...
  43. Antimanic Use During Pregnancy
    Katherine L Wisner; Fiscal Year: 2010
    ..6) Conduct pharmacokinetic (PK) studies on the subset of women who take lithium, the most common drug used to manage BP during pregnancy in our Center, at 20- 24 weeks, 32-36 weeks, and 12-16 ..
  44. Examining the role of the Lissencephaly Protein, Lis1, in Dynein-Based Transport
    Deanna S Smith; Fiscal Year: 2013
    ..Notably, the dynein response to PPAR3 agonists requires PI3K activity and is mimicked by lithium, a potent Gsk32 inhibitor used to treat mood disorders...
  45. Towards a High-Throughput System for Testing Human Candidate-Brain-Disease Allele
    Elizabeth M Simpson; Fiscal Year: 2010
    ..testing, and testing of the most favorable 2 strains for differential effects of the psychotherapeutic drug lithium. Bipolar disorder (manic-depressive disorder) is an incurable, long-term brain disorder affecting 5...
  46. Regulation of neurogenesis and behavior by GSK-3
    Peter S Klein; Fiscal Year: 2013
    ..b>Lithium is highly effective in BD, but the neuropharmacological mechanisms that underlie the therapeutic response is ..
  47. Importance of Beta-Catenin Signaling in Osteocytes Associated with Anabolic Load
    Shiva P Kotha; Fiscal Year: 2012
    ..In this application, we evaluate the dosage of a pharmacological agent (lithium chloride) that can synergize with mechanical loading to activate a powerful pathway (the Wnt/b-catenin signaling) ..
  48. 1/2-Prevention of Relapse &Recurrence of Bipolar Depression
    Robert J Derubeis; Fiscal Year: 2013
    ..In this application, we will ask: "Does continuation therapy with combined lithium plus fluoxetine result in fewer MDE relapses and recurrences vs...
  49. Mechanisms of Cognitive Impairment in Temporal Lobe Epilepsy
    Barbara Jobst; Fiscal Year: 2013
    ..laboratory has recently pursued the underlying mechanisms responsible for dynamic cognitive dysfunction in the lithium-pilocarpine model of TLE finding that interictal spikes (IIS), dysfunctions in network oscillation activity (EEG ..
  50. Multimodal Neuroimaging of Treatment Effects in Adolescent Mania
    Melissa P DelBello; Fiscal Year: 2013
    ..these aims, we will randomize 120 first-hospitalization manic adolescents to double-blind treatment with lithium or quetiapine for 6 weeks, during which time we will perform symptom ratings, as well as fMRI and H-MRS scans...
  51. Genetic Predictors of Lithium Response in Bipolar Disorder
    John R Kelsoe; Fiscal Year: 2013
    ..This frequently results in a lengthy trial and error process of treatment optimization which may take years. Lithium was the first mood stabilizing medication and is still the gold standard for treatment...
  52. Brain Chemistry and Altitude in Bipolar Disorder
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..Despite decades of research, the illness remains poorly understood, and no new treatment has surpassed lithium's effectiveness for the majority of patients...
  53. Lithium's Molecular Mechanism of Action and the Pathology of Bipolar Disorders
    Ramin V Parsey; Fiscal Year: 2013
    ..We will also investigate the 5-HT effects of a common treatment for BPD, lithium. Discovered decades ago, lithium remains one of the few effective treatments in BPD, with evidence of mood ..
  54. Role of ubiquitination in the Wnt pathway
    Ethan Lee; Fiscal Year: 2013
    ..We found that XIAP coimmunoprecipitates with TCF/Lef in the presence of lithium (inhibits GSK3) and that XIAP is phosphorylated by GSK3...
  55. Home-Based Lithium Level Testing for Bipolar Patients
    KUMAR SUBRAMANIAN; Fiscal Year: 2009
    PROJECT SUMIVIARY Lithium whose proprietary names include Eskalith, Lithane, Lithonate, Lithobid and others, is administered as lithium carbonate and used for treatment of the bipolar disorders (BD), mania, and manic-depressive illness...
  56. Improved Batteries for Implantable Cardiac Defibrillators
    Kenneth J Takeuchi; Fiscal Year: 2012
    ..The current benchmark power source technology is lithium/silver vanadium oxide (Li/SVO) developed >20 years ago...
  57. Seizure-induced Neuronal Loss and Epileptogenesis in the Immature Brain
    JEFFREY JOHN EKSTRAND; Fiscal Year: 2013
    ..This project utilizes the lithium pilocarpine (LiPC) animal model of epilepsy, a well established model of chemoconvulsant status epilepticus (SE), ..
  58. Indirubins: novel anti-invasive and anti-angiogenic drugs for malignant gliomas
    E Antonio Chiocca; Fiscal Year: 2013
    ..Based on data showing reduced glioma motility in vitro using lithium, a GSK-3 inhibitor that is FDA-approved for the treatment of bipolar disorders, we have initiated a bi-..
  59. Biology of the orphan receptor Rev-erb alpha
    Mitchell A Lazar; Fiscal Year: 2013
    ..in circadian rhythm and metabolism, utilizing a novel mouse model in which Rev-erb1 is insensitive to the lithium-stimulated degradation pathway...
  60. Pilot PET Study Characterizing [1-11C] Arachadonic Acid in Bipolar Disorder
    M Elizabeth Sublette; Fiscal Year: 2013
    ..In animal studies, mood stabilizers lithium, valproate, carbamazepine, and lamotrigine downregulate the brain AA cascade5...
  61. Glucocorticoid and Stress Induced Cerebellar Neural Progenitor Cell Apoptosis
    Kevin K Noguchi; Fiscal Year: 2013
    ..In Aim 1, the applicant will test the potential safener drug lithium for its ability to protect against GC induced NPC apoptosis and its long term effects in the cerebellum...
  62. Targeting Renal Purinergic Signaling for the Treatment of Lithium-induced NDI
    Bellamkonda K Kishore; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): 6. Project Summary/Abstract Nephrogenic diabetes insipidus (NDI) due to lithium therapy for bipolar disorder is one of the major nephrological problems among Veterans...
  63. Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder
    John R Kelsoe; Fiscal Year: 2013
    ..Studies to date by our group have implicated two genes, NTRK2 and PDE11A as predicting response to lithium. In this project, we propose a two pronged approach: genes will first be sought in an exploratory fashion in a ..
  64. Genetic Risk Factor For Suicidal Behavior
    Virginia L Willour; Fiscal Year: 2013
    ..a key molecule in the Wnt signaling pathway, is noteworthy because the Wnt pathway is positively regulated by lithium, which has been shown to decrease suicidal behavior...
  65. Total Synthesis of Bioactive Marine Natural Products
    Armen Zakarian; Fiscal Year: 2013
    ..1) development and application of methods for efficient asymmetric synthesis using readily available chiral lithium amides as recoverable stereodirecting reagents, 2) total synthesis of complex bioactive molecules, and 3) ..
  66. SNARE Proteins and TBI
    C Edward Dixon; Fiscal Year: 2013
    ..It has recently been discovered that lithium, at therapeutically relevant concentrations, can enhance the expression of CSP[unreadable]...
  67. Improving Gastrointestinal Recovery after Radiation
    George Georges; Fiscal Year: 2007
    ..The drugs are: keratinocyte growth factor (KGF), lithium carbonate (Li2CO3), and a GI-specific formulation of beclomethasone dipropionate (BDP) to be given alone or in ..
  68. ION PAIR ALDOL ADDITION REACTIONS
    Andrew Streitwieser; Fiscal Year: 1999
    ..and that the reaction is now most often run in non-polar solvents, such as tetrahydrofuran (THF), frequently with lithium salts of carbonyl compounds (lithium enolates)...
  69. The effect of lithium on intracellular sodium in brain in vivo
    Richard A Komoroski; Fiscal Year: 2013
    ..b>Lithium (Li) is an important first-line and widely prescribed treatment for acute mania and relapse prevention in BPD...
  70. MOLECULAR TARGETS OF LITHIUM AND VALPROATE
    MIRIAM GREENBERG; Fiscal Year: 2004
    ..Only two drugs are currently approved by the FDA for treatment of this disorder, lithium and valproate...
  71. LITHIUM POTENTIATED STATUS EPILEPTICUS
    RICHARD JOPE; Fiscal Year: 1990
    ..This model uses pretreatment with lithium followed by administration of subthreshold doses of convulsants...
  72. REACTIVITY AND SELECTIVITY OF REACTIONS IN POLAR MEDIA
    PAUL GRIECO; Fiscal Year: 2002
    ..0-5.0 M lithium perchlorate-diethyl ether with applications to molecules of biological interest...
  73. LITHIUM IN AGGRESSIVE CHILDREN WITH CONDUCT DISORDER
    Magda Campbell; Fiscal Year: 1993
    ..We have replicated our earlier findings on the efficacy and safety of lithium carbonate in this type of child: lithium is statistically and clinically superior to placebo in reducing these ..
  74. Clinical Inertia in Prescribing for Bipolar Disorder
    Dominic Hodgkin; Fiscal Year: 2013
    ..trials of treatment for BD: the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), and the Lithium Moderate Use Study (LiTMUS)...
  75. CONTINUATION ECT VS PHARMACOTHERAPY--EFFICACY AND SAFETY
    Teresa Rummans; Fiscal Year: 2001
    ..g., a tricyclic (TCA), a selective serotonin reuptake inhibitor (SSRI), or lithium), as continuation therapy...
  76. Estimating Intracellular Lithium in Brain in vivo by 7Li MRS
    Richard A Komoroski; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lithium (Li) is the treatment of choice for acute mania and for relapse prevention in bipolar disorder...
  77. Improving Battery Performance for Cardiac Pacing
    JEFFREY DEAL; Fiscal Year: 2005
    ..ICDs marketed by Medtronic, St. Jude, and Guidant all use lithium silver vanadium oxide (SVO) battery chemistries and all display a significant increase in charge time, in some ..