cesium

Summary

Summary: A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.

Top Publications

  1. ncbi The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
  2. pmc Cesium toxicity in Arabidopsis
    Corrina R Hampton
    Warwick HRI, Warwick CV35 9EF, United Kingdom
    Plant Physiol 136:3824-37. 2004
  3. ncbi Dealing with the aftermath of Fukushima Daiichi nuclear accident: decontamination of radioactive cesium enriched ash
    Durga Parajuli
    National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba, 305 8565, Japan
    Environ Sci Technol 47:3800-6. 2013
  4. pmc Improved matrix-assisted laser desorption/ionization mass spectrometric detection of glycosaminoglycan disaccharides as cesium salts
    Tatiana N Laremore
    Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Rapid Commun Mass Spectrom 21:1315-20. 2007
  5. ncbi High-level exposure to lithium, boron, cesium, and arsenic via drinking water in the Andes of northern Argentina
    Gabriela Concha
    Division of Toxicology, Swedish National Food Administration, Box 622, S 751 26 Uppsala, Sweden
    Environ Sci Technol 44:6875-80. 2010
  6. ncbi Purification of Toxoplasma gondii oocysts by cesium chloride gradient
    Aurélien Dumètre
    UPRES EA 3174, Neuroparasitologie et neuroépidémiologie tropicale, Faculte de Medecine, 2 rue du Dr Marcland, F 87025 Limoges, France
    J Microbiol Methods 56:427-30. 2004
  7. ncbi Removal of cesium ions from aqueous solution by adsorption onto local Taiwan laterite
    Tsing Hai Wang
    Department of Engineering and System Science, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    J Hazard Mater 160:638-42. 2008
  8. pmc Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia
    D M Liu
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane, Queensland 4072, Australia
    J Physiol 534:423-35. 2001
  9. ncbi Effect of rubidium and cesium ions on the dimeric quaduplex formed by the Oxytricha nova telomeric repeat oligonucleotide d(GGGGTTTTGGGG)
    Flaminia Cesare Marincola
    Dipartimento di Scienze Chimiche, Università di Cagliari Cittadella Universitaria di Monserrato, Monserrato, CA, Italy
    Nucleosides Nucleotides Nucleic Acids 26:1129-32. 2007
  10. ncbi Quantitative determination of cesium binding to ferric hexacyanoferrate: Prussian blue
    Patrick J Faustino
    Division of Product Quality Research, Office of Testing and Research, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
    J Pharm Biomed Anal 47:114-25. 2008

Detail Information

Publications232 found, 100 shown here

  1. ncbi The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
    ..The architecture of the pore establishes the physical principles underlying selective K+ conduction...
  2. pmc Cesium toxicity in Arabidopsis
    Corrina R Hampton
    Warwick HRI, Warwick CV35 9EF, United Kingdom
    Plant Physiol 136:3824-37. 2004
    b>Cesium (Cs) is chemically similar to potassium (K). However, although K is an essential element, Cs is toxic to plants...
  3. ncbi Dealing with the aftermath of Fukushima Daiichi nuclear accident: decontamination of radioactive cesium enriched ash
    Durga Parajuli
    National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba, 305 8565, Japan
    Environ Sci Technol 47:3800-6. 2013
    Environmental radioactivity, mainly in the Tohoku and Kanto areas, due to the long living radioisotopes of cesium is an obstacle to speedy recovery from the impacts of the Fukushima Daiichi Nuclear Power Plant accident...
  4. pmc Improved matrix-assisted laser desorption/ionization mass spectrometric detection of glycosaminoglycan disaccharides as cesium salts
    Tatiana N Laremore
    Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Rapid Commun Mass Spectrom 21:1315-20. 2007
    ..The lithium, sodium, potassium, rubidium, and cesium salts of SOS were analyzed by UV-MALDI-time-of-flight (TOF)MS using an ionic liquid matrix, bis-1,1,3,3-..
  5. ncbi High-level exposure to lithium, boron, cesium, and arsenic via drinking water in the Andes of northern Argentina
    Gabriela Concha
    Division of Toxicology, Swedish National Food Administration, Box 622, S 751 26 Uppsala, Sweden
    Environ Sci Technol 44:6875-80. 2010
    ..drinking water (up to 210 microg/L), we found remarkably high concentrations of lithium (highest 1000 microg/L), cesium (320 microg/L), rubidium (47 microg/L), and boron (5950 microg/L)...
  6. ncbi Purification of Toxoplasma gondii oocysts by cesium chloride gradient
    Aurélien Dumètre
    UPRES EA 3174, Neuroparasitologie et neuroépidémiologie tropicale, Faculte de Medecine, 2 rue du Dr Marcland, F 87025 Limoges, France
    J Microbiol Methods 56:427-30. 2004
    We describe the use of a cesium chloride (CsCl) gradient as an improvement for the purification of Toxoplasma gondii oocysts from concentrated suspensions...
  7. ncbi Removal of cesium ions from aqueous solution by adsorption onto local Taiwan laterite
    Tsing Hai Wang
    Department of Engineering and System Science, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    J Hazard Mater 160:638-42. 2008
    Utilization of local Taiwan laterite (LTL) to remove aqueous cesium was investigated in this work under the conditions of various contact time, cesium (Cs) loading and temperature...
  8. pmc Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia
    D M Liu
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane, Queensland 4072, Australia
    J Physiol 534:423-35. 2001
    ..The relative permeabilities of the monovalent inoganic and organic cations tested are similar to those reported previously for cloned rat P2X(2) receptors expressed in mammalian cells...
  9. ncbi Effect of rubidium and cesium ions on the dimeric quaduplex formed by the Oxytricha nova telomeric repeat oligonucleotide d(GGGGTTTTGGGG)
    Flaminia Cesare Marincola
    Dipartimento di Scienze Chimiche, Università di Cagliari Cittadella Universitaria di Monserrato, Monserrato, CA, Italy
    Nucleosides Nucleotides Nucleic Acids 26:1129-32. 2007
    ....
  10. ncbi Quantitative determination of cesium binding to ferric hexacyanoferrate: Prussian blue
    Patrick J Faustino
    Division of Product Quality Research, Office of Testing and Research, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
    J Pharm Biomed Anal 47:114-25. 2008
    ..is the first FDA approved medical countermeasure for the treatment of internal contamination with radioactive cesium (Cs) or thallium in the event of a major radiological incident such as a "dirty bomb"...
  11. ncbi Cesium adsorption on clay minerals: an EXAFS spectroscopic investigation
    Benjamin C Bostick
    Stanford University, Department of Geological and Environmental Sciences, California 94305 2115, USA
    Environ Sci Technol 36:2670-6. 2002
    b>Cesium adsorption on the clay minerals vermiculite and montmorillonite is described as a function of surface coverage using extended X-ray adsorption fine structure spectroscopy (EXAFS)...
  12. pmc Emission of spherical cesium-bearing particles from an early stage of the Fukushima nuclear accident
    Kouji Adachi
    Meteorological Research Institute, 1 1 Nagamine, Tsukuba, Ibaraki, Japan
    Sci Rep 3:2554. 2013
    ..The finding of the spherical Cs particles will be a key to understand the processes of the accident and to accurately evaluate the health impacts and the residence time in the environment. ..
  13. ncbi Exfoliated nanosheet crystallite of cesium tungstate with 2D pyrochlore structure: synthesis, characterization, and photochromic properties
    Katsutoshi Fukuda
    International Center for Materials Nanoarchitectonics and Nanoscale Materials Center, National Institute for Materials Science, Tsukuba, Ibaraki 305 0044, Japan
    ACS Nano 2:1689-95. 2008
    Layered cesium tungstate, Cs(6+x)W(11)O(36), with two-dimensional (2D) pyrochlore structure was exfoliated into colloidal unilamellar sheets through a soft-chemical process...
  14. ncbi Biosorption of stable cesium by chemically modified biomass of Sargassum glaucescens and Cystoseira indica in a continuous flow system
    R Dabbagh
    Nuclear Science Research School, Nuclear Science Technology Research Institute, Tehran, Iran
    J Hazard Mater 159:354-7. 2008
    ..Stable cesium biosorption was studied in continuous fixed-bed column by chemically modified biosorbents...
  15. ncbi Using elevated CO2 to increase the biomass of a Sorghum vulgare x Sorghum vulgare var. sudanense hybrid and Trifolium pratense L. and to trigger hyperaccumulation of cesium
    Huibin Wu
    Centre for Research in Ecotoxicology and Environmental Remediation, Institute of Agro Environmental Protection, The Ministry of Agriculture, Tianjin 300191, PR China
    J Hazard Mater 170:861-70. 2009
    ..sudanense hybrid and Trifolium pratense L. growing on soils spiked with various levels of cesium (0, 300, 1500 and 3000 mg Cs kg(-1))...
  16. pmc Ih without Kir in adult rat retinal ganglion cells
    Sherwin C Lee
    Section of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616 8519, USA
    J Neurophysiol 97:3790-9. 2007
    ..These results provide the first measurement of I(h) in mammalian retinal ganglion cells and indicate that the ion channels of rat retinal ganglion cells may vary in ways not expected from previous voltage and current recordings...
  17. ncbi Colloid stable sorbents for cesium removal: preparation and application of latex particles functionalized with transition metals ferrocyanides
    Valentin Avramenko
    Institute of Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159 ave 100 letiya Vladivostoka, Vladivostok 690022, Russia
    J Hazard Mater 186:1343-50. 2011
    In this paper we suggest a principally new approach to preparation of colloid stable selective sorbents for cesium uptake using immobilization of transition metals (cobalt, nickel, and copper) ferrocyanides in nanosized carboxylic latex ..
  18. pmc Preliminary assessment of ecological exposure of adult residents in Fukushima Prefecture to radioactive cesium through ingestion and inhalation
    Akio Koizumi
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Environ Health Prev Med 17:292-8. 2012
    This study aims to estimate the ecological exposure of adult residents of Fukushima Prefecture to ¹³⁴cesium (Cs) and ¹³⁷Cs through ingestion and inhalation between July 2 and July 8, 2011.
  19. ncbi Inorganic-organic magnetic nanocomposites for use in preventive medicine: a rapid and reliable elimination system for cesium
    Yoshihisa Namiki
    Institute of Clinical Medicine and Research, The Jikei University School of Medicine, Kashiwa, Japan
    Pharm Res 29:1404-18. 2012
    To investigate the potential use of Prussian blue-coated magnetic nanoparticles, termed "Prussian blueberry", to bring about the magnetic elimination of cesium.
  20. ncbi Low-energy vibrational dynamics of cesium borate glasses
    C Crupi
    Dipartimento di Fisica, Universita di Messina, Viale F Stagno d Alcontres 31, I 98166 Messina, Italy
    J Phys Chem B 116:6499-505. 2012
    Low-temperature specific heat and inelastic light scattering experiments have been performed on a series of cesium borate glasses and on a cesium borate crystal...
  21. pmc Distinct properties of CRAC and MIC channels in RBL cells
    J Ashot Kozak
    Department of Physiology and Biophysics, University of California at Irvine, Irvine, CA 92697, USA
    J Gen Physiol 120:221-35. 2002
    ..The biophysical characteristics of MIC current match well with cloned and expressed TRPM7 channels. Previous results are reevaluated in terms of separate CRAC and MIC channels...
  22. ncbi Electronic circular dichroism in the 4f-4f transitions of a series of cesium tetrakis (+)-3-heptafluorobutyrylcamphorate Ln(III) complexes
    Dai Shirotani
    Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560 0043, Japan
    Dalton Trans 41:10557-67. 2012
    ....
  23. ncbi Dose reduction in skeletal and chest radiography using a large-area flat-panel detector based on amorphous silicon and thallium-doped cesium iodide: technical background, basic image quality parameters, and review of the literature
    Markus Volk
    Department of Diagnostic Radiology, University Hospital of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur Radiol 14:827-34. 2004
    ..The large-area flat-panel detector based on amorphous silicon and thallium-doped cesium iodide provides a significant reduction of radiation dose in skeletal and chest radiography compared with ..
  24. ncbi Chest radiography: optimization of X-ray spectrum for cesium iodide-amorphous silicon flat-panel detector
    James T Dobbins
    Department of Radiology, Duke University Medical Center, 161F Bryan Research Bldg, Research Drive, DUMC Box 3302, Durham, NC 27710, USA
    Radiology 226:221-30. 2003
    To ascertain the optimum x-ray spectrum for chest radiography with a cesium iodide-amorphous silicon flat-panel detector.
  25. ncbi Cesium leaching from gamma-irradiated CsA and CsX zeolites
    Enrique Lima
    Universidad Autonoma Metropolitana, Iztapalapa, A P 55 532, Av San Rafael Atlixco No 186 Col Vicentina, 09340 Mexico, D F, Mexico
    J Hazard Mater 160:614-20. 2008
    ..The incorporation of Cs+ ions into A and X zeolites was performed using three different cesium salts (chloride, nitrate or acetate)...
  26. ncbi A physiologically based biokinetic model for cesium in the human body
    R W Leggett
    Oak Ridge National Laboratory, 1060 Commerce Park, Oak Ridge, TN 37831, USA
    Sci Total Environ 317:235-55. 2003
    A physiologically descriptive model of the biological behavior of cesium in the human body has been constructed around a detailed blood flow model...
  27. pmc Properties and functional roles of hyperpolarization-gated currents in guinea-pig retinal rods
    G C Demontis
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Pisa I 56126, Italy
    J Physiol 515:813-28. 1999
    ....
  28. ncbi Functional expression of the human HCN3 channel
    Juliane Stieber
    Institut fur Pharmakologie und Toxikologie der Technischen Universitat Munchen, Biedersteiner Strasse 29, 80802 Munchen, Germany
    J Biol Chem 280:34635-43. 2005
    ..3. Like all other HCNs, hHCN3 was inhibited rapidly and reversibly by extracellular cesium and slowly and irreversibly by extracellular applied ZD7288...
  29. pmc Gating charge immobilization caused by the transition between inactivated states in the Kv1.5 channel
    Z Wang
    Department of Physiology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Biophys J 81:2614-27. 2001
    ..5-W472F nonconducting mutant channels, and removes charge immobilization. Higher concentrations of Cs are able to modulate the deactivating transition in Kv1.5 channels and prevent the residual slowing of charge return...
  30. ncbi Mechanism underlying rebound excitation in retinal ganglion cells
    Pratip Mitra
    Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Vis Neurosci 24:709-31. 2007
    ..The NDO boosts the generation of conventional sodium spikes which are triggered on its upstroke and crest, thus eliciting rebound excitation...
  31. pmc Modulation of slow inactivation in human cardiac Kv1.5 channels by extra- and intracellular permeant cations
    D Fedida
    Department of Physiology, Botterell Hall, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Physiol 515:315-29. 1999
    ..These results suggest the presence of ion binding sites capable of regulating inactivation located on both intracellular and extracellular sides of the pore selectivity filter...
  32. pmc A trapped intracellular cation modulates K+ channel recovery from slow inactivation
    Evan C Ray
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gen Physiol 128:203-17. 2006
    ..We propose that the rate of recovery from slow inactivation is determined by the ability of entrapped cations to move into a binding site in the channel's selectivity filter, and refilling of this site is required for recovery...
  33. pmc Functional identification of ion binding sites at the internal end of the pore in Shaker K+ channels
    Jill Thompson
    Department of Pharmacology and Physiology, University of Rochester Medical Center, NY 14642, USA
    J Physiol 549:107-20. 2003
    ..These results provide information on the fine-structure of ion interactions with the inner end of the pore in K+ channels...
  34. ncbi Acquired long QT syndrome and monomorphic ventricular tachycardia after alternative treatment with cesium chloride for brain cancer
    Anuj K Dalal
    Department of Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Mayo Clin Proc 79:1065-9. 2004
    ..b>Cesium chloride is an unregulated agent that has been reported to have antineoplastic properties...
  35. ncbi Cesium chloride sensing and signaling in Saccharomyces cerevisiae: an interplay among the HOG and CWI MAPK pathways and the transcription factor Yaf9
    Viviana Casagrande
    Dipartimento di Biologia Cellulare e dello Sviluppo, Istituto Pasteur Fondazione Cenci Bolognetti, Università Sapienza di Roma, Rome, Italy
    FEMS Yeast Res 9:400-10. 2009
    ..In a previous work, we showed that cesium chloride activates the HOG pathway and modulates the transcription of several genes, especially those involved in ..
  36. pmc Specific cesium transport via the Escherichia coli Kup (TrkD) K+ uptake system
    D Bossemeyer
    Abteilung Mikrobiologie, Universitat Osnabruck, Federal Republic of Germany
    J Bacteriol 171:2219-21. 1989
    ..Regardless of the presence or absence of Kup, K+-replete cells took up Cs+ primarily by a very low affinity mode, proportional to the ratio of the Cs+ and K+ concentrations in the medium...
  37. ncbi Cesium effect: high chemoselectivity in direct N-alkylation of amines
    Ralph Nicholas Salvatore
    Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620 5250, USA
    J Org Chem 67:674-83. 2002
    A novel method for the mono-N-alkylation of primary amines, diamines, and polyamines was developed using cesium bases in order to prepare secondary amines efficiently...
  38. pmc Conduction properties of the cloned Shaker K+ channel
    L Heginbotham
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
    Biophys J 65:2089-96. 1993
    ..The single channel conductance displays an anomalous molefraction effect in symmetric mixtures of K+ and NH+4, suggesting that the conducting pore is occupied by multiple ions simultaneously...
  39. ncbi Uncertainty of inductively coupled plasma mass spectrometry based measurements: an application to the analysis of urinary barium, cesium, antimony and tungsten
    A Alimonti
    Department of Environment and Primary Prevention, Italian National Institute of Health, Rome, Italy
    Rapid Commun Mass Spectrom 19:3131-8. 2005
    The wide use of barium (Ba), cesium (Cs), antimony (Sb) and tungsten (W) in many industrial and agricultural fields causes the increased release of these metals into the environment, laying the basis for health risk...
  40. ncbi Inward rectifying currents stabilize the membrane potential in dendrites of mouse amacrine cells: patch-clamp recordings and single-cell RT-PCR
    Amane Koizumi
    Howard Hughes Medical Institute, Massachusetts General Hospital, Wellman 429, Boston, MA 02114, USA
    Mol Vis 10:328-40. 2004
    ..To explore the possible existence of inward rectifying currents in the distal dendrites of amacrine cells...
  41. pmc Uncoupling of gating charge movement and closure of the ion pore during recovery from inactivation in the Kv1.5 channel
    Zhuren Wang
    Department of Physiology, University of British Columbia, Vancouver V6T 1Z3, British Columbia, Canada
    J Gen Physiol 120:249-60. 2002
    ..This difference probably stems from the difference in the respective abilities of the two ions to limit inactivation to the P-type state or prevent it altogether...
  42. ncbi The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
    Yufeng Zhou
    Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute and Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Mol Biol 333:965-75. 2003
    ..We conclude that electrostatic balance and coupling of ion binding to a protein conformational change underlie high conduction rates in the setting of high selectivity...
  43. pmc Patch-clamp analysis in canine cardiac Purkinje cells of a novel sodium component in the pacemaker range
    Marcello Rota
    Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Box 31, Brooklyn, NY 11203, USA
    J Physiol 548:147-65. 2003
    ....
  44. ncbi Mechanisms of adrenergic control of sino-atrial node discharge
    Hengtao Zhang
    Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
    J Biomed Sci 10:179-92. 2003
    ..If I(f) is the primary mechanism, cesium (a blocker of I(f)) should eliminate the positive chronotropic effect of NE...
  45. ncbi Ion binding affinity in the cavity of the KcsA potassium channel
    Yufeng Zhou
    Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Biochemistry 43:4978-82. 2004
    ..These results are consistent with a fairly large (more negative than -100 mV) electrostatic potential inside the cavity, and they also imply the presence of a weak nonelectrostatic component to a cation's interaction with the cavity...
  46. ncbi Biosorption of cesium by native and chemically modified biomass of marine algae: introduce the new biosorbents for biotechnology applications
    R Jalali-Rad
    Department of Biotechnology, Nuclear Research Center, Atomic Energy Organization of Iran, Tehran, Iran
    J Hazard Mater 116:125-34. 2004
    Biosorption batch experiments were conducted to determine the cesium binding ability of native biomass and chemically modified biosorbents derived from marine algae, namely ferrocyanide algal sorbents type 1 and type 2 (FASs1 and FASs2)...
  47. ncbi Comparison of an amorphous silicon/cesium iodide flat-panel digital chest radiography system with screen/film and computed radiography systems--a contrast-detail phantom study
    X J Rong
    Department of Diagnostic Radiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Med Phys 28:2328-35. 2001
    ..In this study, the low-contrast performance of an amorphous silicon/cesium iodide (aSi/Csl)-based flat-panel digital chest radiography system is compared to those of a screen/film and a ..
  48. ncbi Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain
    B Santoro
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 93:717-29. 1998
    ....
  49. ncbi Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation
    V Orlando
    DIBIT HSR Biomedical Scientific Park, Via Olgettina 58, 20132 Milano, Italy
    Trends Biochem Sci 25:99-104. 2000
    ..One of the most useful techniques for studying this level of gene regulation is the in vivo fixation by formaldehyde crosslinking of proteins to proteins and proteins to DNA, followed by immunoprecipitation of the fixed material...
  50. ncbi Cesium chloride induced ventricular arrhythmias in dogs: three-dimensional activation patterns and their relation to the cesium dose applied
    J C Senges
    Medizinische Universitatsklinik, Abteilung Innere Medizin III, Heidelberg, Germany
    Basic Res Cardiol 95:152-62. 2000
    b>Cesium chloride has widely been used in experimental models to produce various ventricular arrhythmias. The study was designed to evaluate whether type and mechanism of these arrhythmias are dose-dependent.
  51. ncbi Spontaneous, electrically, and cesium chloride induced arrhythmia and afterdepolarizations in the rapidly paced dog heart
    D L Jones
    Departments of Physiology and Medicine, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Pacing Clin Electrophysiol 24:474-85. 2001
    ..arrhythmia and early afterdepolarization (EAD) induced triggered activity elicited by exogenous administration of cesium chloride (CsCl). The hearts of 56 mongrel dogs were paced at 240 beats/min for 3-5 weeks (heart failure group)...
  52. ncbi Micro-chemical imaging of cesium distribution in Arabidopsis thaliana plant and its interaction with potassium and essential trace elements
    M P Isaure
    CEA, DRT, LITEN, section d application des traceurs, CEA Grenoble, 17, rue des Martyrs, 38054 Grenoble, Cedex 09, France
    Biochimie 88:1583-90. 2006
    b>Cesium as an alkali element exhibits a chemical reactivity similar to that of potassium, an essential element for plants...
  53. ncbi Cesium attenuation correction of the liver dome revealing hepatic lesion missed with computed tomography attenuation correction because of the respiratory motion artifact
    Dimitri Papathanassiou
    Service de Medecine Nucleaire, Institut Jean Godinot, Reims
    Clin Nucl Med 30:120-1. 2005
  54. ncbi Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line
    E Wischmeyer
    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Pflugers Arch 429:809-19. 1995
    ..It is concluded that RBL cells express a classical voltage-dependent IRK-type K+ inward rectifier RBL-IRK1 which is negatively controlled by G proteins...
  55. ncbi Linking cesium and strontium uptake to kaolinite weathering in simulated tank waste leachate
    Jon Chorover
    Department of Soil, Water and Environmental Science, University of Arizona, Tucson, Arizona 85721, USA
    Environ Sci Technol 37:2200-8. 2003
    ..Discrete strontium silicate solids were also observed. The incongruent dissolution of kaolinite promoted the sequestration of contaminants into increasingly recalcitrant solid phases over the 1-yr time period...
  56. ncbi Electrophysiological characterization of volume-activated chloride currents in mouse cholangiocyte cell line
    Biyi Chen
    Department of Medicine, Division of Gatroenterology Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1158-67. 2004
    ..The present study is the first to characterize the VACC in mouse cholangiocyte and will provide an important framework for further studies to examine and understand the role of the VACC in biliary secretion and ion-transport physiology...
  57. pmc Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones
    T A Simeone
    Department of Anatomy and Neurobiology, University of California, Irvine, 92697, USA
    J Physiol 568:371-80. 2005
    ....
  58. ncbi Hyperpolarization-activated cyclic nucleotide-gated channels in mouse vomeronasal sensory neurons
    Michele Dibattista
    Sector of Neurobiology, International School for Advanced Studies, Scuola Internazionale di Studi Superiori Avanzati, Neurobiology Sector, Via Beirut 2 4, 34014 Trieste, Italy
    J Neurophysiol 100:576-86. 2008
    ..In conclusion, these results show that mouse VNO neurons express HCN2 and/or HCN4 subunits and that Ih contributes to setting the resting membrane potential and to increase excitability at stimulus threshold...
  59. ncbi Impaired regulation of thalamic pacemaker channels through an imbalance of subunit expression in absence epilepsy
    Thomas Budde
    Institut für Experimentelle Epilepsieforschung, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Neurosci 25:9871-82. 2005
    ....
  60. ncbi Nonselective cation current in rabbit ventricular myocytes
    Y D Song
    Peking Union Medical College, National Research Institute for Family Planning, Beijing, China
    Methods Find Exp Clin Pharmacol 27:377-83. 2005
    ..It might be an important factor on the repolarization of the action potential. Changes in NSCC may lead to an induction or inhibition of arrhythmia...
  61. ncbi Involvement of transient receptor potential-like channels in responses to mGluR-I activation in midbrain dopamine neurons
    Alessandro Tozzi
    Experimental Neurology Laboratory, I R C C S Fondazione Santa Lucia Via Ardeatina 306, Rome, Italy
    Eur J Neurosci 18:2133-45. 2003
    ..were not affected by sodium channel blockers, tetrodotoxin and saxitoxin or by inhibition of the h-current with cesium. Abolition of calcium responses with intracellular BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid;..
  62. ncbi Inhibitory synaptic transmission differs in mouse type A and B medial vestibular nucleus neurons in vitro
    Aaron J Camp
    School of Biomedical Sciences and Hunter Medical Research Institute, Faculty of Health, The University of Newcastle, Callaghan, Australia
    J Neurophysiol 95:3208-18. 2006
    ....
  63. ncbi Expression of the inwardly rectifying K+ channel Kir2.1 in native bovine corneal endothelial cells
    Dongli Yang
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    Invest Ophthalmol Vis Sci 44:3511-9. 2003
    ..To determine the presence of Kir2.1 channels in native bovine corneal endothelial (BCE) cells and assess their contribution to the resting membrane potential...
  64. ncbi Depolarization differentially affects the secretory and migratory properties of two cell lines of immortalized luteinizing hormone-releasing hormone (LHRH) neurons
    Federica Pimpinelli
    Laboratory of Developmental Neuroendocrinology, Department of Endocrinology, Center of Excellence on Neurodegenerative Diseases, University of Milano, via G Balzaretti, 9, 20133 Milan, Italy
    Eur J Neurosci 18:1410-8. 2003
    ..The early stage of maturation of GN11 cells, as well as the low electrical activity detected in these cells, appears to correlate with their migratory activity in vitro...
  65. ncbi Vasa recta pericytes express a strong inward rectifier K+ conductance
    Chunhua Cao
    Division of Nephrology, Department of Medicine, N3W143, 22 S Greene St, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1601-7. 2006
    ..We conclude that strong inward rectifier K+ channels and Na+-K+-ATPase contribute to resting potential and that KIR channels can mediate K+-induced hyperpolarization of DVR pericytes...
  66. ncbi Expression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami
    Y Rateau
    Laboratoire de Neurophysiologie et Nouvelles Microscopies, Institut National de la Santé et de la Recherche Médicale U603, Universite Paris Descartes, Paris, France
    J Neurophysiol 95:3073-85. 2006
    ..We show that it has voltage- and time-dependent properties typical of the Ih, that it is blocked by cesium and ZD7288, two blockers of the Ih, and that it is carried both by the K+ and Na+ ions...
  67. ncbi Voltage-gated potassium conductances in Gymnotus electrocytes(AB)
    F Sierra
    Unidad Asociada Neurofisiologia IIBCE, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay
    Neuroscience 145:453-63. 2007
    ..I. Morphology and innervation of the electric organ. J Comp Physiol A 165:343-351]...
  68. ncbi Ethanol effects on electrophysiological properties of astrocytes in striatal brain slices
    Louise Adermark
    Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, NIAAA NIH, 5625 Fishers Lane, TS 13, Bethesda, MD 20892, USA
    Neuropharmacology 51:1099-108. 2006
    ..Astrocytes play a critical role in brain potassium homeostasis, and therefore EtOH effects on astrocytic function could influence neuronal activity...
  69. ncbi Bidirectional interactions between h-channels and Na+-K+ pumps in mesencephalic trigeminal neurons
    Youngnam Kang
    Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    J Neurosci 24:3694-702. 2004
    ....
  70. pmc A novel osmosensitive voltage gated cation current in rat supraoptic neurones
    Xiao Hong Liu
    Department of Physiology, College of Medicine, 107 Wiggins Road, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5
    J Physiol 568:61-8. 2005
    ..This current could play an important role in regulating the response of MNCs to osmolality...
  71. ncbi Molecular and functional analysis of hyperpolarisation-activated nucleotide-gated (HCN) channels in the enteric nervous system
    J Xiao
    Department of Anatomy and Cell Biology and Centre for Neuroscience, University of Melbourne, Parkville, 3010 Victoria, Australia
    Neuroscience 129:603-14. 2004
    ..Our results indicate that HCN1, 2 and 4 genes and protein are expressed in the ENS. AH/Dogiel type II neurons, which have a prominent Ih, express HCN2 and 4 in guinea-pig and HCN1 and 2 in mouse and rat...
  72. ncbi A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus
    Xavier Fioramonti
    CNRS UMR 5018, Paul Sabatier University, Toulouse, France
    Diabetes 53:2767-75. 2004
    ..Moreover, HGE neurons were also present in ARC of Kir6.2 null mice. These results suggested that ARC neurons have the ability to sense higher glucose concentrations than 5 mmol/l through a new K(ATP) channel-independent mechanism...
  73. ncbi 5-Hydroxytryptamine action in the rat olfactory bulb: in vitro electrophysiological patch-clamp recordings of juxtaglomerular and mitral cells
    A Hardy
    Laboratoire de Neurosciences et Systèmes Sensoriels, CNRS, UMR 5020, Universite Claude Bernard, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
    Neuroscience 131:717-31. 2005
    ..This is expected to enrich the understanding of its determining role in olfactory learning...
  74. ncbi Voltage-gated channels and calcium homeostasis in mammalian rod photoreceptors
    David Cia
    Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, Institut National de la Santé et de la Recherche Médicale U 592, Universite Pierre et Marie Curie
    J Neurophysiol 93:1468-75. 2005
    ..This work indicates further that mammalian rods express nonclassic L-type Ca2+ channels, showing a low sensitivity to the diltiazem isomers used in neuroprotective studies...
  75. ncbi An inwardly rectifying potassium channel in apical membrane of Calu-3 cells
    Jin V Wu
    Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305 2130, USA
    J Biol Chem 279:46558-65. 2004
    ..A. (1989) J. Membr. Biol. 110, 139-146). Thus, we hypothesize that the K+ channel described here optimizes the rate of secretion and is involved in K+ recycling for the recently proposed apical H+ -K+ -ATPase in Calu-3 cells...
  76. ncbi Developmental regulation of a Na(+)-activated fast outward K+ current in rat myoblasts
    MiOu Zhou
    Center for Brain Science Research, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, China
    Cell Physiol Biochem 14:225-30. 2004
    ..In this report, we reported a developmental regulation of fast activated and fast inactivated outward current in rat myoblasts...
  77. ncbi Calcium-dependent fast depolarizing afterpotentials in vasopressin neurons in the rat supraoptic nucleus
    Ryoichi Teruyama
    Department of Anatomy and Neurobiology, University of Tennessee, Health Science Center, TN 38163, USA
    J Neurophysiol 98:2612-21. 2007
    ..We speculate that the two DAPs have different roles in generating after burst discharges and could play important roles in determining the distinct firing properties of VP neurons in the SON neurons...
  78. ncbi Plasma-membrane Cnh1 Na+/H+ antiporter regulates potassium homeostasis in Candida albicans
    Olga Kinclova-Zimmermannova
    Department of Membrane Transport, Institute of Physiology AS CR, v v i, Videnska 1083, 142 20 Prague 4 Krc, Czech Republic
    Microbiology 153:2603-12. 2007
    ..albicans revealed that this antiporter plays a significant role in C. albicans physiology. It ensures potassium and rubidium tolerance and participates in the regulation of intracellular potassium content of C. albicans cells...
  79. ncbi Enhanced Ih depresses rat entopeduncular nucleus neuronal activity from high-frequency stimulation or raised Ke+
    D S Shin
    Division of Fundamental Neurobiology, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, Ontario, Canada
    J Neurophysiol 99:2203-19. 2008
    ..This mechanism could underlie the inhibitory effects of HFS used in deep brain stimulation in output basal ganglia nuclei...
  80. ncbi Differential effects of extracellular cesium on early afterdepolarizations in ventricular myocytes and arrhythmogenesis in isolated hearts of rats and guinea pigs
    C Ian Spencer
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Medical Institutions, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Pflugers Arch 448:478-89. 2004
    ..A comparison of such results with the effects of these solutions on myocytes suggests that I(K1) inhibition and EADs in ventricular myocytes are unlikely to be involved in arrhythmogenesis under our conditions...
  81. ncbi Repeated cocaine administration increases voltage-sensitive calcium currents in response to membrane depolarization in medial prefrontal cortex pyramidal neurons
    Fernando J Nasif
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 25:3674-9. 2005
    ..These findings indicate that chronic exposure to cocaine facilitates the responsiveness of I(Ca), particularly via the activated L-type Ca2+ channels, to excitatory stimuli in rat mPFC pyramidal neurons...
  82. ncbi [Electrophysiology of two human hyperpolarization activated cyclic nucleotide-gated potassium channels expressed in HEK293 cells]
    Chun Li
    Department of Cardiology, People s Hospital, Peking University, Beijing 100044, China
    Zhonghua Yi Xue Za Zhi 87:706-9. 2007
    ..To express the human HCN2 and HCN4 genes in HEK293 cells and investigate the electrophysiology of the expressed channel protein...
  83. ncbi Amyloid beta-protein fragment 31-35 suppresses delayed rectifying potassium channels in membrane patches excised from hippocampal neurons in rats
    Jin Shun Qi
    Department of Neurobiology, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China
    Synapse 51:165-72. 2004
    ....
  84. ncbi Reexamination of the role of hyperpolarization-activated cation channels in short- and long-term plasticity at hippocampal mossy fiber synapses
    Chiung Chun Huang
    Department of Pharmacology, College of Medicine, National Cheng Kung University, No 1, Ta Hsiue Road, Tainan City 701, Taiwan
    Neuropharmacology 44:968-81. 2003
    ..Therefore, we conclude that I(h) channels may contribute to the development and regulation of short- and long-term plasticity at the mossy fiber-CA3 synapses...
  85. pmc Nonselective currents and channels in plasma membranes of protoplasts from coats of developing seeds of bean
    Wen Hao Zhang
    School of Biological Sciences, The Flinders University of South Australia, G P O Box 2100, Adelaide, South Australia 5001, Australia
    Plant Physiol 128:388-99. 2002
    ..The higher conductance channel in 10 mM KCl had P(K):P(Cl) = 2.8. Such nonselective channels in the seed coat ground parenchyma cell could function to allow some of the efflux of phloem-imported univalent ions into the seed apoplast...
  86. ncbi Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels
    Jack Mellor
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Science 295:143-7. 2002
    ..Thus, Ih channels play an important role in the long-lasting control of transmitter release and neuronal excitability...
  87. ncbi Potassium conductances in isolated single cells from Xenopus laevis colonic epithelium
    B Heinke
    , , Germany
    J Comp Physiol B 169:148-56. 1999
    ..Barium and cesium showed pronounced voltage-dependent blockage, with interaction at about 35% inside the pores...
  88. pmc Inwardly rectifying whole cell potassium current in human blood eosinophils
    M Tare
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, UK
    J Physiol 506:303-18. 1998
    ..5. It is concluded that the single channel currents and the whole cell current rectification observed in human blood eosinophils resulted from the presence of an inwardly rectifying potassium channel, probably Kir2.1...
  89. ncbi Modulation of the human polycystin-L channel by voltage and divalent cations
    Yan Liu
    Membrane Protein Research Group, Department of Physiology, University of Alberta, 729 MSB, T6G 2H7, Edmonton, AB, Canada
    FEBS Lett 525:71-6. 2002
    ..This study shows that although PCL is not a voltage-gated channel, its channel activity and inhibition by Mg2+ are modulated by membrane potential...
  90. pmc Sodium fluxes through nonselective cation channels in the plasma membrane of protoplasts from Arabidopsis roots
    Vadim Demidchik
    Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA United Kingdom
    Plant Physiol 128:379-87. 2002
    ..It is suggested that NSCCs present a distinct group of plant ion channels, mediating toxic Na(+) influx to the cell and probably having other important roles in physiological processes of plants...
  91. ncbi Characteristics of hyperpolarization-activated cation currents in portal vein smooth muscle cells
    I A Greenwood
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, SW17 0RE UK
    Am J Physiol Cell Physiol 282:C744-53. 2002
    ..This conductance appears to determine, in part, the rhythmicity of this vessel...
  92. ncbi A telencephalic nucleus essential for song learning contains neurons with physiological characteristics of both striatum and globus pallidus
    Michael A Farries
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 22:3776-87. 2002
    ..We suggest that area X contains a pathway equivalent to the "direct" striatopallidothalamic pathway through the mammalian basal ganglia, with the striatal and pallidal components intermingled in one nucleus...
  93. pmc Molecular determinants of the inhibition of human Kv1.5 potassium currents by external protons and Zn(2+)
    Steven J Kehl
    Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3
    J Physiol 541:9-24. 2002
    ....
  94. pmc Fast network oscillations induced by potassium transients in the rat hippocampus in vitro
    Fiona E N LeBeau
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, UK
    J Physiol 542:167-79. 2002
    ....
  95. pmc Ionic currents in isolated and in situ squid Schwann cells
    Isao Inoue
    Institute for Enzyme Research, Tokushima University, Japan
    J Physiol 541:769-78. 2002
    ..The results suggest that calcium channels and calcium-activated K+ channels play an important role in the generation of the squid Schwann cell membrane potential, which may be controlled by the resting intracellular Ca2+ level...
  96. ncbi Dependence of Na+-K+ pump current-voltage relationship on intracellular Na+, K+, and Cs+ in rabbit cardiac myocytes
    Peter S Hansen
    Department of Cardiology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Am J Physiol Cell Physiol 283:C1511-21. 2002
    ..The dielectric coefficient derived from [Na]pip-Ip relationships at the different test potentials was 0.15 when pipette solutions included 80 mM K+ and 0.06 when pipette solutions were K+ free...
  97. ncbi Motor pattern switching in the heartbeat pattern generator of the medicinal leech: membrane properties and lack of synaptic interaction in switch interneurons
    J Lu
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    J Comp Physiol A 184:311-24. 1999
    ..We discuss how the switch leak conductance may interact with the intrinsic currents of switch interneurons to control their activity state...
  98. ncbi Intrinsic firing dynamics of vestibular nucleus neurons
    Chris Sekirnjak
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 22:2083-95. 2002
    ..We conclude that the heterogeneity of firing dynamics observed in response to head movements in intact animals reflects intrinsic as well as circuit properties...
  99. ncbi Gating mechanism of the cloned inward rectifier potassium channel from mouse heart
    K Ishihara
    Department of Cardiovascular Diseases, Tokyo Medical and Dental University, Japan
    J Membr Biol 142:55-64. 1994
    ..Our results suggest the existence of the intrinsic gating mechanism, accounting for the extent of rectification in the current-voltage relationship in the expressed channel...
  100. ncbi Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    Biochim Biophys Acta 1512:273-84. 2001
    ..Furthermore, OCTN2 was localized on the apical membrane of renal tubular epithelial cells. These results clarified that OCTN2 is important for the concentrative reabsorption of L-carnitine after glomerular filtration in the kidney...
  101. ncbi Membrane properties of principal neurons of the lateral superior olive
    T J Adam
    The Rotary Hearing Centre, Department of Surgery (Otolaryngology, University of British Columbia, Vancouver, Canada
    J Neurophysiol 86:922-34. 2001
    ..These active membrane properties endow the LSO principal neurons with an adaptability that may maintain a stable code for sound direction under changing conditions, for example after partial cochlear hearing loss...

Research Grants62

  1. High Sensitivity Mobile PET for Brain Imaging and Proton Therapy Monitoring
    Georges El Fakhri; Fiscal Year: 2010
    ..It also features Cesium Iodide (CsI) detector technology with wavelength shift fiber readout that allows high sensitivity (~2X whole body ..
  2. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2010
    ..Public Health Relevance: Permanent implantation of radioactive seeds containing iodine-125, palladium-103, or cesium-131 in the prostate, also called brachytherapy, has become a popular form of radiation therapy for carefully ..
  3. Gammacell 1000 Elite Self-Contained Blood Irradiator
    Shobu Namura; Fiscal Year: 2013
    ..The Gammacell 1000 Elite is a self-contained gamma irradiator using a cesium source...
  4. Purchase and installation of X-Rad 320 Biological irradiator for USC Keck School
    Colin K Hill; Fiscal Year: 2010
    ..It is intended that this machine will eventually replace an aging AECL cesium gamma irradiator that has been in use at the School of Medicine since 1983...
  5. Perlecan modulates VEGF Bio-Availability in Human Osteoarthritic Cartilage
    RONALD GOMES; Fiscal Year: 2009
    ..Under the first aim, an already proven cesium chloride density gradient centrifugation and anion exchange chromatography approach will be used to purify ..
  6. Self-contained X-ray Blood Irradiator
    BABU CHALAMALA; Fiscal Year: 2010
    ..Most blood irradiators in existence today are based on radioactive isotopes, mainly Cesium-137 and in some cases Cobalt- 60...
  7. Yale Comprehensive Cancer Center Support Grant
    THOMAS JAMES LYNCH; Fiscal Year: 2013
    ..for 8 Shared Resources including Yale Center for Genome Analysis, Flow Cytometry, Yale Pathology Tissue Services, Cesium Irradiator, Rapid Case Ascertainment, Yale Center for Molecular Discovery, Biostatistics and the Clinical Trials ..
  8. Flat-panel X-ray Imaging Detector with Avalanche Gain
    Wei Zhao; Fiscal Year: 2013
    ..The proposed detector employs three major components: a structured cesium iodide (CsI) scintillator to convert x-rays to optical photons;an avalanche amorphous selenium (a-Se) ..
  9. Planning Grant for a Study of the Effect of Radiation o*
    Camille Ragin; Fiscal Year: 2006
    ..Chernobyl were exposed to much higher than normal levels of radioiodine and other radioactive isotopes, especially cesium and strontium...
  10. STRUCTURE, SYNTHESIS AND ASSEMBLY OF PICORNAVIRUSES
    ROLAND RUECKERT; Fiscal Year: 1991
    ..to examine the effect of the drug on a variety of physical properties including pH stability, permeability to cesium ion and isoelectric A-B transition...
  11. Mechanisms of serum electrolyte effects on block of HERG
    Alan Miller; Fiscal Year: 2006
    ..HERG channels to study the mechanisms by which the extracellular monovalent cations potassium, rubidium, and cesium and the divalent cations calcium and magnesium alter block of HERG by a number of different compounds selected ..
  12. NATIONAL RESOURCE FOR IMAGING MASS SPECTROMETRY
    Claude Lechene; Fiscal Year: 2003
    ..Instrumental development (brighter Cesium primary ion source, iodine negative primary ion source, impregnation by 'soft landing' of the primary atoms) will ..
  13. HIGH RESOLUTION STRUCTURE OF MULTI COMPONENT VIRUSES
    John Johnson; Fiscal Year: 1993
    ..component, which is biologically identical to the bottom component but has exchanged endogenous polyamines for cesium ions, will also be investigated. Crystals of all the components are isomorphous and different to 2...
  14. CAPSULE SYNTHESIS BY MUCOID PSEUDOMONAS AERUGINOSA
    MARILYN STEELE; Fiscal Year: 1992
    ..DNA from mucoid strains of P. aeruginosa will be isolated by cesium chloride density gradient centrifugation, digested with Eco Rl, ligated into lambda gtll, and introduced into E...
  15. IMPROVED ADENO ASSOCIATED VIRUS PURIFICATION
    Anthony Green; Fiscal Year: 1999
    ..Current processes using three (3) consecutive Cesium chloride gradients are cumbersome, inefficient and difficult to scale-up...
  16. DRUG EFFECTS ON IMPULSE INITIATION IN THE HEART
    KENNETH DANGMAN; Fiscal Year: 1991
    ..which occurs from maximum diastolic potentials of -61 to -70 mV) and low potential automaticity in barium- or cesium- pretreated Purkinje fibers...
  17. CESIUM IODIDE CONVERTER FOR RADIATION THERAPY
    Gerald Entine; Fiscal Year: 2000
    ..propose to test the feasibility of developing a more efficient area detector for high energy x-rays by casting cesium iodide converter into the holes of a metal honeycomb structure and reading out by amorphous silicon diode array, ..
  18. IMAGING STRUCTURE AND FUNCTION IN SMALL ANIMALS
    Bruce Hasegawa; Fiscal Year: 2001
    ..1) A pinhole SPECT system will be developed using a pixellated silicon pixel array and thallium-doped cesium iodide (CsI(Tl)) scintillator for radionuclide imaging of small animals...
  19. IMPROVED GENE THERAPY VECTOR PURIFICATION
    Anthony Green; Fiscal Year: 2000
    ..process of an ion- exchange and PolyFlo chromatography results in product of high purity and yield that exceeds cesium chloride...
  20. CLUSTER ION PRIMARY BEAM SOURCE FOR LIQUID SIMS
    WILLIAM ABERTH; Fiscal Year: 1992
    ..The use of cluster ions instead- of the customary cesium or xenon atoms for the primary beam, provides a means of increasing the surface energy deposition and thereby ..
  21. MARK I, RESEARCH IRRADIATOR WITH CESIUM 137 SOURCE
    Kevin Shannon; Fiscal Year: 1999
    This application requests funds to purchase a cesium 137 irradiation source to operate within the barrier Animal Care Facility (ACF) at the Parnassus Heights campus of the University of California, San Francisco (UCSF)...
  22. CESIUM IRRADIATOR FOR MEDICAL RESEARCH
    Evan Douple; Fiscal Year: 1992
    This application requests funds to purchase a cesium irradiator for the irradiation shared service laboratory at the Dartmouth-Hitchcock Medical Center (DHMC)...
  23. PURCHASE OF TRIPLE QUADRUPOLE MASS SPECTROMETER
    Alan Sartorelli; Fiscal Year: 1991
    ..Accessories requested with this instrument are a cesium ion source(SIMS), a continuous flow FIB probe, and an electrospray ion source...
  24. Mark I, Model 68A Cesium 137 Research Irradiator
    Robert Paulson; Fiscal Year: 2003
    Via NIH's Shared Instrumentation Grant Program, funds are requested to purchase a Cesium-137 irradiator designed for the whole body irradiation of mice...
  25. MECHANISM OF ACTION OF SULFONATE ESTER ANTICANCER DRUGS
    Neil Gibson; Fiscal Year: 1992
    ..adducts will be analysed by high pressure liquid chromatography and DNA-protein crosslinks will be identified by cesium chloride gradients and gel electorphoresis...
  26. Cesium 137 Irradiator: Model 68
    Stanton Gerson; Fiscal Year: 2005
    The investigators request for the purchase of a small animal radiator, Mark I Cesium Irradiator model 68, to support NIH funded research in stem cell biology, stem cell transplantation and cancer...
  27. Mark I Model 68 Gamma Irradiator
    Robert Weiss; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): This proposal is to request funding for the purchase of a Mark I Model 68 Cesium-137 gamma irradiator. The instrument will be located adjacent to an exclusion barrier animal facility...
  28. Mark I Model 68A Rodent/Cell line Gamma Irradiator
    Sanford Feldman; Fiscal Year: 2004
    The purpose of this submission is to request funding to purchase a Mark I Model 68A rodent cesium (137Cs) irradiator for use by several PHS funded scientists that require this item of specialized equipment to irradiate mice or cell lines ..
  29. METHODOLOGY FOR ONCOLOGY IMAGING WITH A PET/CT SCANNER
    David Townsend; Fiscal Year: 2002
    ..For this purpose, the PET/CT scanner is equipped with collimated cesium point sources operating in singles mode...
  30. A NEW APPROACH FOR BIOMEDICAL IMAGING
    JAMES WINEFORDNER; Fiscal Year: 2002
    ..This research project will develop and optimize resonance ionization image devices using mercury and cesium as active elements...
  31. A NEW APPROACH FOR BIOMEDICAL IMAGING
    JAMES WINEFORDNER; Fiscal Year: 2003
    ..This research project will develop and optimize resonance ionization image devices using mercury and cesium as active elements...
  32. DETECTORS FOR LARGE BIOMOLECULAR IONS
    Katrin Fuhrer; Fiscal Year: 1999
    ..It is the aim of this proposal to investigate the use of novel Lithium and Cesium based material for fabrication of high efficiency large ion detectors, either by ion-electron or by ion-H-..
  33. High-Resolution Ion Beam Probe for Biological Research
    SAMAR GUHARAY; Fiscal Year: 2002
    ..The primary demand to achieve this goal is a high-brightness ion beam probe at low energy, using either oxygen or cesium species...
  34. Gammacell 40 Exactor Research Irradiator
    EDWARD SCOTT; Fiscal Year: 2005
    ..Gammacell 40 Exactor Self-Contained Low Dose Rate Research Irradiator (Cat. # GC40) complete with two cesium 137 sources (Cat. # GC40C440), which will be capable of delivering a central dose rate of 110 rad/min...
  35. DEVELOPMENTAL CONTROL OF THE DIAPHRAGM AND UPPER AIRWAYS
    William Cameron; Fiscal Year: 2003
    ....
  36. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  37. Ion Regulation of Kv Channel Gating and Permeation
    Carol Deutsch; Fiscal Year: 2007
    ..The second aim will test whether ions in the selectivity filter modulate the movement of voltage sensors. These studies will entail measurements of kinetics and voltage dependence of gating currents in HEK cells. ..
  38. SYNTHESIS OF MDR REVERSING POLYENES
    MERRITT ANDRUS; Fiscal Year: 2003
    ..This is an important first step toward a molecular understanding of the unique recognition properties, transport mechanism of Pgp, and will further facilitate the design of new, more potent reversal agents. ..
  39. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..Synthetic approaches to isodomoic acid H, hepatitis C viral inihibiting indole alkaloids, the salicylihalimide macrolactone oximidine II, and polyene antiviral antibiotic viridenomycin are detailed. ..
  40. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2008
    ..All of the innovations uncovered during the preparation of these nanoprobes will be shared in order to benefit medical research applications beyond those proposed in this investigation. ..
  41. Development of Selective Nanoporous Sorbents for Radionuclide Decorporation
    Charles Timchalk; Fiscal Year: 2008
    ..have been demonstrated to be highly effective chelators for Plutonium, neptunium, uranium, americium, radioiodide, cesium and cobalt, all of which can be normally found in nuclear bombs and ROD...
  42. Nano-scale Mechanisms of Metal(loid) Rhizostabilization in Desert Mine Tailings
    JONATHAN D CHOROVER; Fiscal Year: 2011
    ..This research is both timely and necessary as growth in the US Southwest is exploding and communities are being developed in closer proximity to such tailings sites. ..
  43. Oligopyrrole-based Anion Binding Agents
    Jonathan L Sessler; Fiscal Year: 2010
    ..abstract_text> ..
  44. Endocannabinoids in COX-2-Mediated Synaptic Modification and Neurotoxicity
    Chu Chen; Fiscal Year: 2010
    ..The outcome from the proposed project will also provide new targets for designing drugs aimed at treating or alleviating COX-2-mediated degenerative diseases. ..
  45. Biomaterials as Decorporation Agents for Radionuclides
    TATIANA LEVITSKAIA; Fiscal Year: 2008
    ..abstract_text> ..
  46. Radioprotective Potential of Ginseng
    Tung Kwang Lee; Fiscal Year: 2006
    ..Accomplishing these aims will provide an essential prerequisite to the development of NAGE as an effective radioprotector. ..
  47. Early Detection of Lung Cancer via Bi Plane Correlation
    Ehsan Samei; Fiscal Year: 2002
    ..The findings will be used to demonstrate the capability of the approach for improving the detection of lung nodules, and thus the prognosis of lung cancer. ..
  48. NEURONAL ORGANIZATION OF BASAL GANGLIA
    Charles Wilson; Fiscal Year: 2003
    ..This latter will allow us to determine whether there is an actual mismatch between physiological and anatomical estimates of connectivity (i.e. non-functional synaptic connections). ..
  49. Medicinal Inorganic Chemistry ACS Symposium F-2003
    Jonathan Sessler; Fiscal Year: 2003
    ..It is thus expected that the present MIC-ACS symposium will afford a unique opportunity to develop further growth in a field of study that is rich in opportunity and central to the NIH mission. ..
  50. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  51. Redox control of Nrf2/ARE by thioredoxin and GSH
    Jason Hansen; Fiscal Year: 2005
    ..The roles of GSH and cytosolic and nuclear TRX during NRF2 activation and binding will provide an essential foundation for future developmental toxicology. ..
  52. Ethanol Effects of SR Ca2+ Release in Cardiac Myocytes
    J Wasserstrom; Fiscal Year: 2005
    ....
  53. Spike After-Potentials of Oxytocin Cells in Lactation
    Ryoichi Teruyama; Fiscal Year: 2005
    ..The specific aims of the application are to determine 1) what specific component of spike after-potentials (AHPs and DAP) is altered during lactation; 2) whether the responsive component is responsive to changes in the gonadal steroids. ..
  54. Molecular Functions of the Adenovirus E1A Oncogene
    Maurice Green; Fiscal Year: 2006
    ..The functional consequences of interaction between E1A and specific cellular promoters will be established by kinetic studies of the gene specific mRNA and protein products. ..
  55. INNOVATIVE BIOMONITORING FOR LEAD IN SALIVA
    Charles Timchalk; Fiscal Year: 2006
    ..It is reasonable to speculate that once this model system has been adequately validated it can readily be employed to screen sensitive populations (e.g. children) that are at greatest risk from chronic Pb exposure. ..
  56. NEOSTRIATAL CHOLINERGIC INTERNEURONS FIRING PATTERNS
    Charles Wilson; Fiscal Year: 2001
    ....