anions

Summary

Summary: Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.

Top Publications

  1. pmc Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels
    Alessio Accardi
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    J Gen Physiol 123:109-19. 2004
  2. ncbi Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein
    D Oliver
    Department of Physiology II, University of Tubingen, 72074 Tubingen, Germany
    Science 292:2340-3. 2001
  3. ncbi Molecular tweezers with varying anions: a comparative study
    Som Dutt
    Department of Chemistry, University of Duisburg Essen, Universitätsstr 7, 45117 Essen, Germany
    J Org Chem 78:6721-34. 2013
  4. pmc Nitrate efflux is an essential component of the cryptogein signaling pathway leading to defense responses and hypersensitive cell death in tobacco
    David Wendehenne
    Unite Mixte de Recherche, Institut National de la Recherche Agronomique Université de Bourgogne, Biochimie, Biologie Cellulaire et Ecologie des Interactions Plantes Micro organismes, 17 rue Sully, BP 86510, 21065 Dijon Cedex, France
    Plant Cell 14:1937-51. 2002
  5. ncbi Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry
    Tomoyoshi Soga
    Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997 0052, Japan
    Anal Chem 81:6165-74. 2009
  6. pmc Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1
    Zhen Tao
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    J Biol Chem 281:10263-72. 2006
  7. pmc Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis
    Mirjam Moviat
    Department of Intensive Care Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Crit Care 7:R41-5. 2003
  8. pmc Membrane cholesterol content modulates activation of volume-regulated anion current in bovine endothelial cells
    I Levitan
    Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6306, USA
    J Gen Physiol 115:405-16. 2000
  9. pmc Central functions of bicarbonate in S-type anion channel activation and OST1 protein kinase in CO2 signal transduction in guard cell
    Shaowu Xue
    Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA, USA
    EMBO J 30:1645-58. 2011
  10. ncbi Role of protein-water interactions and electrostatics in alpha-synuclein fibril formation
    Larissa A Munishkina
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 43:3289-300. 2004

Detail Information

Publications395 found, 100 shown here

  1. pmc Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels
    Alessio Accardi
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    J Gen Physiol 123:109-19. 2004
    ..the currents have a subnernstian reversal potential in a KCl gradient, indicating imperfect selectivity for anions over cations...
  2. ncbi Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein
    D Oliver
    Department of Physiology II, University of Tubingen, 72074 Tubingen, Germany
    Science 292:2340-3. 2001
    ..Here, we show that voltage sensitivity is conferred to prestin by the intracellular anions chloride and bicarbonate...
  3. ncbi Molecular tweezers with varying anions: a comparative study
    Som Dutt
    Department of Chemistry, University of Duisburg Essen, Universitätsstr 7, 45117 Essen, Germany
    J Org Chem 78:6721-34. 2013
    ..The combination of experiment and theory provides deep insight into the host-guest binding modes, a prerequisite to understanding the exciting influence of these tweezers on the aggregation of proteins and the activity of enzymes. ..
  4. pmc Nitrate efflux is an essential component of the cryptogein signaling pathway leading to defense responses and hypersensitive cell death in tobacco
    David Wendehenne
    Unite Mixte de Recherche, Institut National de la Recherche Agronomique Université de Bourgogne, Biochimie, Biologie Cellulaire et Ecologie des Interactions Plantes Micro organismes, 17 rue Sully, BP 86510, 21065 Dijon Cedex, France
    Plant Cell 14:1937-51. 2002
    ..Our results indicate that anion channels are involved intimately in mediating defense responses and hypersensitive cell death...
  5. ncbi Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry
    Tomoyoshi Soga
    Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997 0052, Japan
    Anal Chem 81:6165-74. 2009
    ..The material of the spray needle had significant effect on the measurement of anions. A stainless steel spray needle was oxidized and corroded at the anodic electrode due to electrolysis...
  6. pmc Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1
    Zhen Tao
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    J Biol Chem 281:10263-72. 2006
    ..Our data are consistent with a model in which Asp-367, but not Asp-454, is involved in coordinating the bound Na(+) in the glutamate-free transporter form...
  7. pmc Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis
    Mirjam Moviat
    Department of Intensive Care Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Crit Care 7:R41-5. 2003
    ..Metabolic acidosis is the most frequent acid-base disorder in the intensive care unit. The optimal analysis of the underlying mechanisms is unknown...
  8. pmc Membrane cholesterol content modulates activation of volume-regulated anion current in bovine endothelial cells
    I Levitan
    Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6306, USA
    J Gen Physiol 115:405-16. 2000
    ..We hypothesize that changes in membrane cholesterol modulate VRAC activity by affecting the membrane deformation energy associated with channel opening...
  9. pmc Central functions of bicarbonate in S-type anion channel activation and OST1 protein kinase in CO2 signal transduction in guard cell
    Shaowu Xue
    Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA, USA
    EMBO J 30:1645-58. 2011
    ..A new working model of the sequence of CO(2) signalling events in gas exchange regulation is presented...
  10. ncbi Role of protein-water interactions and electrostatics in alpha-synuclein fibril formation
    Larissa A Munishkina
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 43:3289-300. 2004
    ..We show here that anions induce partial folding of alpha-synuclein at neutral pH, forming a critical amyloidogenic intermediate, which ..
  11. ncbi Differential Al resistance and citrate secretion in barley (Hordeum vulgare L.)
    Zhuqing Zhao
    Faculty of Agriculture, Kagawa University, Ikenobe 2393, Miki cho, Kita gun, 761 0795 Kagawa, Japan
    Planta 217:794-800. 2003
    ..The activity of citrate synthase was unaffected by Al in both Al-resistant and Al-sensitive varieties. The secretion rate of organic acid anions from barley was the lowest among wheat, rye and triticale.
  12. ncbi Synthesis of dendritic polyglycerol anions and their efficiency toward L-selectin inhibition
    Marie Weinhart
    Institute of Chemistry and Biochemistry, Freie Universitaet Berlin, Takustr 3, 14195 Berlin, Germany
    Biomacromolecules 12:2502-11. 2011
    ..1,3-dipolar cycloaddition ("click-reaction") of polyglycerolazide precursors and alkyne-functionalized anions such as sulfonates, carboxylates, phosphonates, and bisphosphonates...
  13. pmc Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters
    Alessandra Picollo
    Department of Molecular Physiology and Biophysics, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Nat Struct Mol Biol 16:1294-301. 2009
    ..We propose that CLC-ec1 operates through an affinity-switch mechanism and that the bases of substrate specificity are conserved in the CLC channels and transporters...
  14. ncbi External concentration of organic acid anions and pH: key independent variables for studying how organic acids inhibit growth of bacteria in mildly acidic foods
    C E Carpenter
    Dept of Nutrition and Food Sciences, Utah State Univ, Logan, 84322, USA
    J Food Sci 74:R12-5. 2009
    ..growth of bacteria in mildly acidic foods are not fully understood, it is clear that intracellular accumulation of anions is a primary contributor to inhibition of bacterial growth...
  15. ncbi Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions
    Maki Hasegawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    J Pharmacol Exp Ther 300:746-53. 2002
    ..These results suggest that rOat1 and rOat3 are mainly responsible for the renal uptake of PAH and pravastatin, respectively...
  16. ncbi Superoxide anions are involved in doxorubicin-induced ERK activation in hepatocyte cultures
    Rosaura Navarro
    Department of Physiology, Medicine and Dentistry School, University of the Basque Country, 48080 Bilbao, Spain
    Ann N Y Acad Sci 1090:419-28. 2006
    ..These results suggest that superoxide anions, probably generated by DOX metabolism, are involved in the effects of the anthracycline on the MAP kinase cascade ..
  17. pmc Spatial distribution of maxi-anion channel on cardiomyocytes detected by smart-patch technique
    Amal K Dutta
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Biophys J 94:1646-55. 2008
    ..This study showed that the smart-patch technique provides a powerful method to detect a unitary event of channels that are localized at some specific site in the narrow region...
  18. ncbi The maxi-anion channel: a classical channel playing novel roles through an unidentified molecular entity
    Ravshan Z Sabirov
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, 444 8585, Japan
    J Physiol Sci 59:3-21. 2009
    ..3 nm and permits passage not only of Cl(-) but also of some intracellular large organic anions, thereby releasing major extracellular signals and gliotransmitters such as glutamate(-) and ATP(4-)...
  19. ncbi Mechanisms of aluminum-tolerance in two species of citrus: secretion of organic acid anions and immobilization of aluminum by phosphorus in roots
    Lin Tong Yang
    Institute of Horticultural Plant Physiology, Biochemistry and Molecular Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China
    Plant Sci 180:521-30. 2011
    ..The higher Al-tolerance of C. sinensis may involve secretion of OA anions and precipitation of Al by P in roots.
  20. ncbi Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice
    Satish A Eraly
    Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 281:5072-83. 2006
    ..In addition, we have determined the levels of approximately 60 endogenous organic anions in the plasma and urine of wild-type and knock-out mice...
  21. pmc HvALMT1 from barley is involved in the transport of organic anions
    Benjamin D Gruber
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT, 2601, Australia
    J Exp Bot 61:1455-67. 2010
    ..conferred both inward and outward currents when expressed in Xenopus laevis oocytes that were bathed in a range of anions including malate...
  22. pmc Differential modulation of ATP-induced P2X7-associated permeabilities to cations and anions of macrophages by infection with Leishmania amazonensis
    Camila Marques-da-Silva
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 6:e25356. 2011
    ..the phenomenon of macrophage membrane permeabilization can involve at least two distinct pathways for cations and anions respectively...
  23. ncbi Imidazolium receptors for the recognition of anions
    Juyoung Yoon
    Department of Chemistry and Division of Nano Sciences, Ewha Womans University, 11 1 Daehyon Dong, Sodaemun Ku, Seoul 120 750, Korea
    Chem Soc Rev 35:355-60. 2006
    ....
  24. ncbi ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages
    Julieta Schachter
    Laboratório de Imunobiofísica, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Cell Sci 121:3261-70. 2008
    ....
  25. pmc Residues important for nitrate/proton coupling in plant and mammalian CLC transporters
    Eun Yeong Bergsdorf
    Department of Physiology and Pathology of Ion Transport, Leibniz Institut für Molekulare Pharmakologie FMP and Max Delbrück Centrum für Molekulare Medizin MDC, D 13125 Berlin, Germany
    J Biol Chem 284:11184-93. 2009
    ..Gating and proton glutamates play similar roles in bacterial, plant, and mammalian CLC anion/proton exchangers...
  26. ncbi Mechanism of the insulin-releasing action of alpha-ketoisocaproate and related alpha-keto acid anions
    Henrike Heissig
    Institute of Pharmacology and Toxicology, Technical University of Braunschweig, Mendelssohnstrasse 1, D 38106 Braunschweig, Germany
    Mol Pharmacol 68:1097-105. 2005
    ..K(ATP) channel inhibition contributes to insulin release by alpha-ketoisocaproate and related alpha-keto acid anions, which are generally believed to act via beta-cell metabolism...
  27. ncbi Biophysical characterization of anionic lipoplexes
    Siddhesh D Patil
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA
    Biochim Biophys Acta 1711:1-11. 2005
    ..These studies confirm the utility of biophysical studies to identify optimal formulation conditions to design efficient liposomal gene delivery vectors...
  28. ncbi Microfluidic chip-capillary electrophoresis for two orders extension of adjustable upper working range for profiling of inorganic and organic anions in urine
    Wen Peng Guo
    Department of Chemistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, P R China
    Electrophoresis 31:3044-52. 2010
    To meet the need for onsite monitoring of urine anions, a microfluidic chip-capillary electrophoresis device was designed, fabricated and tested to extend the upper CE working range for an enhancement up to 500 fold (100 fold for sample ..
  29. ncbi Differential maturation of GABA action and anion reversal potential in spinal lamina I neurons: impact of chloride extrusion capacity
    Matilde Cordero-Erausquin
    Division de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, G1J 2G3, Canada
    J Neurosci 25:9613-23. 2005
    ..Immature spinal GABA signaling may thus contribute to the nociceptive hypersensitivity in infant rats...
  30. pmc The Saccharomyces cerevisiae weak-acid-inducible ABC transporter Pdr12 transports fluorescein and preservative anions from the cytosol by an energy-dependent mechanism
    C D Holyoak
    Microbiology Department, Unilever Research Colworth, Sharnbrook, Bedford MK44 1LQ, United Kingdom
    J Bacteriol 181:4644-52. 1999
    ..Thus, these data provide strong evidence that sorbate and benzoate anions compete with fluorescein for a putative monocarboxylate binding site on the Pdr12 transporter.
  31. pmc A mutation in autosomal dominant myotonia congenita affects pore properties of the muscle chloride channel
    C Fahlke
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 94:2729-34. 1997
    ..Both binding sites are preserved in the mutant but have decreased affinities for iodide. These findings suggest that Gly 230 is critical for normal ion conductance in hClC-1 and that this residue resides within the channel pore...
  32. ncbi CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells
    Juntaro Negi
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Nature 452:483-6. 2008
    ..Increased [CO2] has been shown to enhance anion channel activity proposed to mediate efflux of osmoregulatory anions (Cl- and malate(2-)) from guard cells during stomatal closure...
  33. pmc Salts enhance both protein stability and amyloid formation of an immunoglobulin light chain
    Laura A Sikkink
    Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Biophys Chem 135:25-31. 2008
    ..Our study emphasizes the importance of the effect of ions in the protein bound water properties and downplays the role of specific interactions between the protein and ions...
  34. ncbi NH(2)-terminal modification of a channel-forming peptide increases capacity for epithelial anion secretion
    J R Broughman
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    Am J Physiol Cell Physiol 280:C451-8. 2001
    ..These results indicate that N-K(4)-M2GlyR forms an anion-selective channel in epithelial monolayers and shows therapeutic potential for the treatment of hyposecretory disorders such as cystic fibrosis...
  35. ncbi Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells
    Masaru Motojima
    Department of Pharmacology, Tokyo Women s Medical University, School of Medicine, Tokyo, Japan
    Kidney Int 63:1671-80. 2003
    ..The present study examined the signaling pathway that is activated by uremic toxins to induce PAI-1 and activate NF-kappaB in human renal proximal tubular cells (HK-2)...
  36. pmc Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3
    Elizabeth A Cowley
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    J Physiol 538:747-57. 2002
    ....
  37. ncbi Effects of superoxide anions on endothelial Ca2+ signaling pathways
    W F Graier
    Department of Medical Biochemistry, University of Graz, Austria
    Arterioscler Thromb Vasc Biol 18:1470-9. 1998
    ..diabetes and hypercholesterolemia, has been proposed frequently, there is limited knowledge as to how superoxide anions (O2-) might affect endothelial signal transduction...
  38. pmc Dual-mode phospholipid regulation of human inward rectifying potassium channels
    Wayland W L Cheng
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, USA
    Biophys J 100:620-8. 2011
    ..In conclusion, we utilized purified proteins in defined lipid membranes to quantitatively determine the phospholipid requirements for human Kir channel activity...
  39. ncbi Sizing the pore of the volume-sensitive anion channel by differential polymer partitioning
    Vadim I Ternovsky
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    FEBS Lett 576:433-6. 2004
    ..The cut-off radius of the VSOR channel pore was assessed to be 0.63 nm...
  40. ncbi Aluminium tolerance in plants and the complexing role of organic acids
    J F Ma
    Faculty of Agriculture, Kagawa University, Ikenobe 2393, Miki cho, Kita gun, 761 0795, Kagawa, Japan
    Trends Plant Sci 6:273-8. 2001
    ..In at least two species, wheat and maize, the transport of organic acid anions out of the root cells is mediated by aluminium-activated anion channels in the plasma membrane...
  41. pmc Cytosolic abscisic acid activates guard cell anion channels without preceding Ca2+ signals
    Victor Levchenko
    Department of Molecular Plant Physiology and Biophysics, Julius von Sachs Institute for Biosciences, Biocenter, Wurzburg University, Julius von Sachs Platz 2, D97082 Würzburg, Germany
    Proc Natl Acad Sci U S A 102:4203-8. 2005
    ..6 microM ABA. Our studies point to an ABA pathway initiated by ABA binding to a cytosolic receptor that within seconds activates anion channels, and in turn, leads to depolarization of the plasma membrane...
  42. ncbi Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
    Jeffrey A M Coull
    Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    Nature 424:938-42. 2003
    ....
  43. pmc Oxidation of single-stranded oligonucleotides by carbonate radical anions: generating intrastrand cross-links between guanine and thymine bases separated by cytosines
    Conor Crean
    Chemistry Department and Radiation and Solid State Laboratory, 31 Washington Place, New York University, New York, NY 10003 5180, USA
    Nucleic Acids Res 36:742-55. 2008
    ..Cross-link formation (n = 0) was also observed in double-stranded DNA molecules derived from the self-complementary 5'-d(TTACGTACGTAA) sequence following exposure to CO3*- radicals and enzymatic excision of the 5'-d(G*pT*) product...
  44. pmc CFTR: covalent and noncovalent modification suggests a role for fixed charges in anion conduction
    S S Smith
    Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Gen Physiol 118:407-31. 2001
    ..The results are consistent with the hypothesis that in wild-type CFTR, R334 occupies a position where its charge can influence the distribution of anions near the mouth of the pore.
  45. pmc Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel
    Chantal N St Aubin
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Gen Physiol 128:535-45. 2006
    ..These results suggest that positively charged arginine residues act to concentrate Cl(-) ions at the inner mouth of the CFTR pore, and that this contributes to maximization of the rate of Cl(-) ion permeation through the pore...
  46. ncbi Separation of fluoride from other monovalent anions using multilayer polyelectrolyte nanofiltration membranes
    Seong Uk Hong
    Department of Chemical Engineering, Hanbat National University, Daejeon 305 719, South Korea
    Langmuir 23:1716-22. 2007
    ....
  47. ncbi Fragmentations of (M-H)- anions of underivatised peptides. Part 2: Characteristic cleavages of Ser and Cys and of disulfides and other post-translational modifications, together with some unusual internal processes
    Daniel Bilusich
    Department of Chemistry, The University of Adelaide, SA 5005, Australia
    Mass Spectrom Rev 28:20-34. 2009
    ..we described the characteristic backbone cleavages and side chain fragmentations which occur from (M-H)(-) parent anions of underivatized peptides. This work is briefly summarized in the present review...
  48. ncbi Unmeasured anions account for most of the metabolic acidosis in patients with hyperlactatemia
    Alexandre Toledo Maciel
    Department of Medical Emergencies, Sao Paulo University Medical School, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 62:55-62. 2007
    ....
  49. ncbi Exudation of organic acid anions from poplar roots after exposure to Al, Cu and Zn
    Ruijun Qin
    Swiss Federal Institute for Forest, Snow and Landscape Research WSL, CH 8903 Birmensdorf, Switzerland
    Tree Physiol 27:313-20. 2007
    ..Significant positive correlations between the organic acid anions and the cations indicate possible co-release...
  50. pmc A nondesensitizing kainate receptor point mutant
    Naushaba Nayeem
    Department of Pharmacology, School of Biomedical Sciences, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK
    Mol Pharmacol 76:534-42. 2009
    ..Unlike GluR6 wild type, the D776K mutant is insensitive to external cations but retains sensitivity to external anions. We therefore hypothesize that the unexpected phenotype of this charge reversal mutation results from the ..
  51. pmc Mechanism of ion permeation in skeletal muscle chloride channels
    C Fahlke
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    J Gen Physiol 110:551-64. 1997
    ..oocytes and in a mammalian cell line by investigating block by extracellular or intracellular I- and related anions. Extracellular and intracellular I- exert blocking actions on hClC-1 currents that are both concentration and ..
  52. ncbi Regulation of skeletal muscle Ca2+ release channel (ryanodine receptor) by Ca2+ and monovalent cations and anions
    G Meissner
    Department of Biochemistry, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    J Biol Chem 272:1628-38. 1997
    ..curves were obtained in media containing different monovalent cations (Li+, Na+, K+, Cs+, and choline+) and anions (Cl-, Mes-, and Pipes-)...
  53. ncbi Rate and extent of ion-exchange process: the effect of physico-chemical characteristics of salicylate anions
    Kaisa Hänninen
    Pharmaceutical Technology Division, and Viikki Drug Discovery Technology Center, Department of Pharmacy, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
    J Control Release 91:449-63. 2003
    Ten salicylate anions were used as model compounds in order to investigate systematically the impact of compound lipophilicity, valence, aqueous solubility and hydrogen bonding on binding into and release from a strong anion-exchange ..
  54. ncbi Water oxidation by electrodeposited cobalt oxides--role of anions and redox-inert cations in structure and function of the amorphous catalyst
    Marcel Risch
    FB Physik, Freie Universitat Berlin, Berlin, Germany
    ChemSusChem 5:542-9. 2012
    ..Cyclic voltammograms in a potassium phosphate buffer at pH 7 revealed that no specific combination of anions and redox-inactive cations is required for catalytic water oxidation...
  55. ncbi Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions
    Alfonso Maresca
    Universita degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, 50019 Sesto Fiorentino Florence, Italy
    J Inorg Biochem 110:36-9. 2012
    ..Here we report the inhibition of these two CAs by inorganic and complex anions and other molecules interacting with zinc proteins, such as sulfamide, sulfamic acid, and phenylboronic/arsonic ..
  56. pmc Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore
    Xiandi Gong
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada
    J Physiol 549:387-97. 2003
    ..the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel is blocked by highly lyotropic permeant anions which bind tightly within the pore...
  57. pmc A quinoline based bis-urea receptor for anions: a selective receptor for hydrogen sulfate
    Tiffany H Russ
    Department of Chemistry and Biochemistry, Jackson State University, 1400 J R Lynch Street, P O Box 17910, Jackson, MS 39212, USA
    Nat Prod Commun 7:301-4. 2012
    ..The results show that the receptor binds each of the anions with a 1:1 stoichiometry, showing high affinity and moderate selectivity for hydrogen sulfate among the anions ..
  58. pmc Ion-π interactions in ligand design for anions and main group cations
    Michelle M Watt
    Department of Chemistry and Materials Science Institute, University of Oregon, Eugene, Oregon 97403 1253, United States
    Acc Chem Res 46:955-66. 2013
    ..This type of interaction could offer new selectivity in binding poorly basic, strongly solvated anions and may also affect structure, biological function, and anion transport...
  59. pmc Enhanced pH-mediated stacking of anions for CE incorporating a dynamic pH junction
    Stacy D Arnett
    Department of Chemistry, Ralph N Adams Institute of Bioanalytical Chemistry, University of Kansas, Lawrence, KS, USA
    Electrophoresis 28:3786-93. 2007
    ..With this technique, mass-loading capacity can be increased without degradation in peak shape and resolution is dramatically improved...
  60. ncbi Influence of sex differences on the renal secretion of organic anions
    J L Reyes
    Department of Physiology, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico, D F
    Endocrinology 139:1581-7. 1998
    The kidney's responsiveness to male sexual hormones has been often neglected. Renal secretion of organic anions is higher in male than in female individuals; as a consequence, most of the xenobiotics that are excreted from the organism ..
  61. ncbi Molecular recognition of anions by synthetic receptors
    P D Beer
    Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QR, UK
    Curr Opin Chem Biol 1:475-82. 1997
    ..Additionally, macroscopic devices such as anion specific electrodes and membranes based on a molecular recognition approach are now being made...
  62. ncbi Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide
    U Andersson
    Department of Biochemistry, University of Oxford, United Kingdom
    Biochem Biophys Res Commun 249:512-6. 1998
    ..The maximal activities of aconitase and oxoglutarate dehydrogenase were both decreased by 25-30% by superoxide anions; however, only the maximal activity of aconitase was decreased, by approximately 50%, by incubation of muscles ..
  63. ncbi Cations but not anions regulate the responsiveness of kainate receptors
    David M MacLean
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G OB1
    J Neurosci 31:2136-44. 2011
    ..glutamate receptors are unique among ligand-gated ion channels in their obligate requirement of external anions and cations for activation...
  64. pmc A combined patch-clamp and electrorotation study of the voltage- and frequency-dependent membrane capacitance caused by structurally dissimilar lipophilic anions
    D Zimmermann
    Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max von Laue Strasse 3, D 60438, Frankfurt am Main, Germany
    J Membr Biol 221:107-21. 2008
    ..The combined approach provides complementary information on the lipophilicity, preferential affinity of the anions to the inner/outer membrane leaflet, adsorption depth and transmembrane mobility...
  65. ncbi Sample stacking of fast-moving anions in capillary zone electrophoresis with pH-suppressed electroosmotic flow
    J P Quirino
    Faculty of Science, Himeji Institute of Technology, Hyogo, Japan
    J Chromatogr A 850:339-44. 1999
    On-line sample concentration of fast moving inorganic anions by large volume sample stacking (LVSS) and field enhanced sample injection (FESI) with a water plug under acidic conditions is presented...
  66. ncbi Investigation of the interactions of polyhedral borane anions with serum albumins
    William Jefferson McVey
    Department of Chemistry and Biochemistry, Texas State University, San Marcos, 601 University Drive, San Marcos, TX 78666, USA
    J Inorg Biochem 102:943-51. 2008
    The retention of polyhedral borane anions within tumor cells has been attributed to the possible formation of covalent bonds with nucleophilic protein substituents...
  67. ncbi Endothelial nitric oxide synthase reduces nitrite anions to NO under anoxia
    Clement Gautier
    Laboratory for Optics and Biosciences, INSERM U696, CNRS UMR 7645, Ecole Polytechnique, Palaiseau, France
    Biochem Biophys Res Commun 341:816-21. 2006
    In this work, we demonstrate that endothelial nitric oxide synthase is capable of anoxic reduction of nitrite anions to nitric oxide at physiological pH by absorption and EPR spectroscopy and electrochemical measurements...
  68. ncbi Synthesis and characterization of indolocarbazole-quinoxalines with flat rigid structure for sensing fluoride and acetate anions
    Ting Wang
    Research Center for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China
    Org Biomol Chem 6:1751-5. 2008
    ..structure with a large pi system, and exhibits high binding affinity and sensitivity for acetate and fluoride anions. Receptors 6 and 7 give abundant and unique spectral features in dimethyl sulfoxide (DMSO)...
  69. ncbi [3.3]Ferrocenophanes with guanidine bridging units as multisignalling receptor molecules for selective recognition of anions, cations, and amino acids
    Francisco Otón
    Universidad de Murcia, Departamento de Quimica Organica, Facultad de Quimica, Campus de Espinardo 30100 Murcia, Spain
    Chemistry 13:5742-52. 2007
    ..In this nitrogen-rich structural motif the guanidine bridges act as multipoint binding sites for anions, cations, and amino acids...
  70. ncbi Contribution of various metabolites to the "unmeasured" anions in critically ill patients with metabolic acidosis
    Miriam Moviat
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Crit Care Med 36:752-8. 2008
    ..to investigate the acid-base balance, includes the strong ion gap (SIG), a quantitative measure of "unmeasured" anions, which strongly correlates to the corrected anion gap...
  71. ncbi Thermal stabilization of human albumin by medium- and short-chain n-alkyl fatty acid anions
    Andrew Shrake
    Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biopolymers 81:235-48. 2006
    A comprehensive study of the thermal stabilization of defatted human albumin monomer by n-alkyl fatty acid anions (FAAs), formate through n-decanoate, was carried out by differential scanning calorimetry (DSC)...
  72. ncbi Silver oxide nanocrystals anchored on titanate nanotubes and nanofibers: promising candidates for entrapment of radioactive iodine anions
    Dongjiang Yang
    College of Chemistry, Chemical and Environmental Engineering, Laboratory of Fiber Materials and Modern Textile, the Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China
    Nanoscale 5:11011-8. 2013
    ..In this study, a new adsorbent structure with the potential to efficiently remove radioactive iodine anions (I(-)) from water is devised: silver oxide (Ag2O) nanocrystals firmly anchored on the surface of titanate ..
  73. ncbi Nitrile anions: solvent-dependent cyclizations
    Fraser F Fleming
    Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282 1530, USA
    J Org Chem 67:2885-8. 2002
    ..Collectively the cyclizations suggest a continuum of nitrile anion transition states, varying from planar to fully pyramidal, that selectively cyclize to cis- and trans-decalins, respectively...
  74. ncbi Simultaneous determination of inorganic anions and cations in explosive residues by ion chromatography
    Hong Bo Meng
    Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China
    Talanta 76:241-5. 2008
    ..and cation-exchange columns directly was developed for the separation and determination of five inorganic anions (sulfate, nitrate, chloride, nitrite, and chlorate) and three cations (sodium, ammonium, and potassium) ..
  75. pmc Modulation of the decay of Ca2+-activated Cl- currents in rabbit portal vein smooth muscle cells by external anions
    I A Greenwood
    Department of Pharmacology and Clinical Pharmacology, Cardiovascular Research Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Physiol 516:365-76. 1999
    1. The effects of external anions on the decay kinetics of Ca2+-activated Cl- currents (ICl(Ca)) were studied in smooth muscle cells isolated from rabbit portal vein using the perforated patch whole-cell voltage clamp technique. 2...
  76. pmc A possible CO2 conducting and concentrating mechanism in plant stomata SLAC1 channel
    Qi Shi Du
    National Engineering Research Center for Non food Biorefinery, Guangxi Academy of Sciences, Nanning, China
    PLoS ONE 6:e24264. 2011
    ..Based on the SLAC1 structure a theoretical model is derived to illustrate the activation of bicarbonate to SLAC1 channel. Meanwhile a possible CO(2) conducting and concentrating mechanism of the SLAC1 is proposed...
  77. ncbi Exploring rearrangements along the fragmentation of glutaric acid negative ion: a combined experimental and theoretical study
    Basem Kanawati
    Institute of Ecological Chemistry, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstadter Landstr 1, D 85758 Neuherberg, Germany
    Rapid Commun Mass Spectrom 24:1198-206. 2010
    ..The DFT study also reveals that a combined loss of CO2 and H2O in the form of H2CO3 is possible...
  78. ncbi Coordination and organometallic compounds as anion receptors and sensors
    Jonathan W Steed
    Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE
    Chem Soc Rev 38:506-19. 2009
    ..The use of anion binding coordination polymer systems in anion separations and in supramolecular gels is also examined...
  79. ncbi Toxicity of various anions associated with methoxyethyl methyl imidazolium-based ionic liquids on Clostridium sp
    Hao Wang
    Department of Chemistry and Environmental Sciences, New Jersey Institute of Technology, Newark, NJ 07104, USA
    Chemosphere 82:1597-603. 2011
    ..These anions, in association with [MOEMIM](+) lowered the growth rate of the bacterium, showing the following trend: [Tf₂N]⁻..
  80. ncbi Occurrence of pharmaceutically acceptable anions and cations in the Cambridge Structural Database
    Delia A Haynes
    Department of Chemistry, Pfizer Institute for Pharmaceutical Materials Science, Lensfield Road, Cambridge, CB2 1EZ, United Kingdom
    J Pharm Sci 94:2111-20. 2005
    ..The CSD was also searched for co-crystals of the list of pharmaceutically acceptable acids and bases corresponding to the list of counterions used for the salt investigation...
  81. ncbi The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules
    Tomoki Imaoka
    Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Am Soc Nephrol 15:2012-22. 2004
    The renal secretion of organic anions across the proximal tubules is achieved by a coordination of uptake and efflux transporters...
  82. pmc Effects of monovalent anions of the hofmeister series on DPPC lipid bilayers Part I: swelling and in-plane equations of state
    A Aroti
    Department of Chemistry, University of Cyprus, Nicosia, Cyprus
    Biophys J 93:1580-90. 2007
    ..specific anion effects in biological systems we have studied the effects of sodium salts of simple monovalent anions belonging to the Hofmeister series on the bilayers of the zwitterionic lipid 1,2-dipalmitoyl-sn-glycero-3-..
  83. pmc Infrared multiphoton dissociation of small-interfering RNA anions and cations
    Myles W Gardner
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712 0165, USA
    J Am Soc Mass Spectrom 21:580-91. 2010
    ..The single-strand siRNA anions were observed to dissociate via cleavage of the 5' P-O bonds yielding c- and y-type product ions as well as ..
  84. ncbi Photocatalytic treatment of 4-chlorophenol in aqueous ZnO suspensions: intermediates, influence of dosage and inorganic anions
    Umar Ibrahim Gaya
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM Serdang, Selangor DE, Malaysia
    J Hazard Mater 168:57-63. 2009
    ..The addition of small amounts of inorganic anions as SO(4)(2-), HPO(4)(-), S(2)O(8)(2-) and Cl(-) revealed two anion types: active site blockers and rate enhancers...
  85. ncbi Simultaneous determination of anionic intermediates for Bacillus subtilis metabolic pathways by capillary electrophoresis electrospray ionization mass spectrometry
    Tomoyoshi Soga
    Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan
    Anal Chem 74:2233-9. 2002
    ..This method was applied to the comprehensive analysis of metabolic intermediates extracted from Bacillus subtilis, and 27 anionic metabolites could be directly detected and quantified...
  86. ncbi Interactions of inorganic phosphate and sulfate anions with collagen
    Edward L Mertz
    National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Building 9, Room 1E125, Bethesda, Maryland 20892 0924, USA
    Biochemistry 43:14901-12. 2004
    ..sites, their dissociation constants, and preferential interaction parameters for inorganic phosphate and sulfate anions in collagen fibrils from rat tail tendons...
  87. ncbi Chromogenic and fluorogenic chemosensors and reagents for anions. A comprehensive review of the year 2009
    María E Moragues
    Centro Interuniversitario de Reconocimiento Molecular y Desarrollo Tecnológico, IDM, Unidad Mixta Universidad Politécnica de Valencia Universitat de València, Spain
    Chem Soc Rev 40:2593-643. 2011
    This critical review is focused on examples reported in the year 2009 dealing with the design of chromogenic and fluorogenic chemosensors or reagents for anions (264 references).
  88. ncbi Anion binding by metallo-receptors of 5,5'-dicarbamate-2,2'-bipyridine ligands
    Biao Wu
    Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi an, 710069, China
    Dalton Trans 40:5687-96. 2011
    ..Interestingly, the carbamate functionalities are involved in hydrogen bonding with various guests (anions or solvents), especially in the tris(chelate) complexes which feature the well-organized C(3)-clefts for effective ..
  89. ncbi Base and phosphate electron detachment energies of deoxyribonucleotide anions
    Viatcheslav V Zakjevskii
    Department of Chemistry, Kansas State University, Manhattan, KS 66506 3701, USA
    J Am Chem Soc 128:13350-1. 2006
    Photoelectron spectra of deoxyribonucleotide anions are interpreted with ab initio, electron propagator calculations...
  90. ncbi Mitochondria-targeted penetrating cations as carriers of hydrophobic anions through lipid membranes
    Tatyana I Rokitskaya
    Belozersky Institute of Physico Chemical Biology, Moscow State University, Vorobyevy Gory 1, Moscow 119991, Russia
    Biochim Biophys Acta 1798:1698-706. 2010
    ..In particular, the leakage of CF was maximal at n about 10-12 and substantially decreased at n=16. Organic anions (palmitate, oleate, laurylsulfate) competed with CF for the penetrating cation-induced efflux...
  91. ncbi Electronically regulated thermally and light-gated electron transfer from anions to naphthalenediimides
    Samit Guha
    Department of Chemistry and Biochemistry and Integrative NanoScience Institute, Florida State University, 95 Chieftan Way, Tallahassee, Florida 32306 4390, United States
    J Am Chem Soc 133:15256-9. 2011
    ..Both pathways generate NDI(•-) radical anions.
  92. ncbi Rapid removal of heavy metal cations and anions from aqueous solutions by an amino-functionalized magnetic nano-adsorbent
    Shih Hung Huang
    Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan
    J Hazard Mater 163:174-9. 2009
    ..magnetic nano-adsorbent shows a quite good capability for the rapid and efficient adsorption of metal cations and anions from aqueous solutions via the chelation or ion exchange mechanisms...
  93. ncbi Novel CalphaNN structural motif for protein recognition of phosphate ions
    Konstantin A Denessiouk
    Department of Biochemistry and Pharmacy, Abo Akademi University, Artillerigatan 6, PO Box 66, FIN 20521 Turku, Finland
    J Mol Biol 345:611-29. 2005
    ..Moreover, the CalphaNN motif is positioned in functionally important regions of protein structures and often residues of the motif directly participate in the function of the protein...
  94. pmc Citrate transporters play a critical role in aluminium-stimulated citrate efflux in rice bean (Vigna umbellata) roots
    Jian Li Yang
    College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310029, China
    Ann Bot 97:579-84. 2006
    ..The physiological bases responsible for the delayed response were examined here...
  95. ncbi Adrenergic regulation of salt and fluid secretion in human medullary collecting duct cells
    Darren P Wallace
    Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Physiol Renal Physiol 287:F639-48. 2004
    ..We conclude that 1) catecholamines stimulate cAMP-dependent anion and fluid secretion by IMCDi cells primarily through beta2-AR activation and 2) alpha2-AR activation attenuates cAMP-dependent anion secretion...
  96. ncbi Carbonic anhydrase inhibitors. Inhibition of transmembrane isoforms IX, XII, and XIV with less investigated anions including trithiocarbonate and dithiocarbamate
    Alessio Innocenti
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem Lett 20:1548-50. 2010
    ..2.1.1) isoforms IX, XII (tumor-associated), and XIV with anions such as stannate(IV), selenate(VI), tellurate(VI), perosmate(VIII), persulfate, pyrophosphate(V), pyrovanadate(V), ..
  97. ncbi Solvation of small disulfonate anions in water/methanol mixtures characterized by high-field pulse electron nuclear double resonance and molecular dynamics simulations
    Jeannine Heller
    Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany
    J Phys Chem B 114:7429-38. 2010
    ..In particular, this includes the potential perturbation of the H-bond network due to the presence of a spin probe or other polar molecules...
  98. ncbi High resolution dissociative electron attachment to gas phase adenine
    D Huber
    Institut für Ionenphysik und Angewandte Physik and Center for Molecular Biosciences, Leopold Franzens Universitat Innsbruck, Technikerstrasse 25, A 6020 Innsbruck, Austria
    J Chem Phys 125:084304. 2006
    ..for measurements requiring high mass resolution, high sensitivity, and relative ion yields for all the fragment anions and a hemispherical electron monochromator instrument for high electron energy resolution...
  99. ncbi Metastable anions of dinitrobenzene: resonances for electron attachment and kinetic energy release
    A Mauracher
    Institut für Ionenphysik und Angewandte Physik and Center for Molecular Biosciences Innsbruck, Leopold Franzens Universitat, 6020 Innsbruck, Austria
    J Chem Phys 133:244302. 2010
    ..of free, low-energy electrons to dinitrobenzene (DNB) in the gas phase leads to DNB(-) as well as several fragment anions. DNB(-), (DNB-H)(-), (DNB-NO)(-), (DNB-2NO)(-), and (DNB-NO(2))(-) are found to undergo metastable (unimolecular) ..
  100. ncbi Adsorption of molybdate and tetrathiomolybdate onto pyrite and goethite: effect of pH and competitive anions
    Nan Xu
    Center for Environmental Systems, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ 07030, USA
    Chemosphere 62:1726-35. 2006
    ..The preferred adsorption by iron mineral of MoS4(2-), as well as its behavior in the presence of competitive anions suggests that tetrathiomolybdate species may be an ultimate reservoir and may control Mo enrichment in the ..
  101. pmc Kosmotropic anions promote conversion of recombinant prion protein into a PrPSc-like misfolded form
    Rodrigo Diaz-Espinoza
    Department of Neurology, Mitchell Center for Alzheimer s Disease and Related Brain Disorders, University of Texas Houston Medical School, Houston, Texas, United States of America
    PLoS ONE 7:e31678. 2012
    ..of protease resistant-recPrP was time and salt-concentration dependent and required the presence of kosmotropic anions such as F(-) or SO(4)(-2)...

Research Grants63

  1. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..mechanisms we are now investigating a possible mechanism involving direct oxidation of iodide (and azide) anions by excited state MB to produce iodide/azide radicals that efficiently kill microbial cells...
  2. INTRACOCHLEAR ELECTROCHEMICAL GRADIENTS
    Alexander A Spector; Fiscal Year: 2012
    ..Prestin belongs to a family of membrane proteins that facilitate the movement of anions (negatively charged ions such as chloride) through the cell membrane...
  3. System for Decontaminating Well Water for Drinking
    GIRISH SRINIVAS; Fiscal Year: 2010
    ..Not only are dissolved metals a problem, but soluble anions such as perchlorate, nitrate and nitrite are hazardous at higher concentrations. Common contaminants in U.S...
  4. Regulation of Hepatic Uptake of Endogenous Signaling Molecules and Xenobiotics
    Ivan Csanaky; Fiscal Year: 2013
    ..Organic anion transporting polypeptides (Oatps) transport a broad range of organic anions. The liver-specific transporter Oatp1b2 (in rodents) has hum an orthologs OATP1B1 and OATP1B3, which are ..
  5. Investigating the Import Mechanism of Folded Proteins into Peroxisomes
    Angelyn Larkin; Fiscal Year: 2013
    ..mitochondria, these organelles segregate toxic reactive oxygen species, such as hydrogen peroxide and superoxide anions, from the rest of the cell to prevent damage to proteins and nucleic acids associated with many diseases, ..
  6. Ca2+ Waves in Hepatocytes: Mechanisms and Effects
    Michael H Nathanson; Fiscal Year: 2013
    ..The effects of impaired Ca2+ signaling or knockdown of InsP3R-2 or AC6 on secretion of organic anions and bile acids will be monitored directly in isolated hepatocytes and in perfused liver preparations;(2) How Ca2+ ..
  7. Novel Mitochondrial Ion Transporters
    BRIAN O'ROURKE; Fiscal Year: 2013
    ..g. K+, Na+, Ca2+, and anions) in the regulation of bioenergetics has become increasingly evident in recent years...
  8. Iron functionalized silica as oral phosphate binder to treat hyperphosphatemia
    Wassana Yantasee; Fiscal Year: 2012
    ..studies show that Fe-SAMMS has a phosphate binding ability that is not dependent on pH or other competing anions relevant to gastrointestinal tract, is composed of benign chemicals including silica, iron, and, ethylenediamine- ..
  9. Redox regulation of alveolar fluid balance
    My N Helms; Fiscal Year: 2012
    ..in place to balance the redox state of type 1 and type 2 cells, since inspired oxygen is converted to superoxide anions (O2-)...
  10. UV Photodissociation for Acidic and Basic Proteome Characterization
    Jennifer S Brodbelt; Fiscal Year: 2012
    ..is largely due to the lack of tandem MS techniques suitable for efficient and predictable dissociation of peptide anions. We propose to develop an innovative ultraviolet photodissociation (UVPD) strategy that offers the ability to ..
  11. Studies on a Novel Taxane Pump
    Elizabeth Hopper-Borge; Fiscal Year: 2011
    ..Our laboratory has shown that MRP7 is competent in the transport of amphipathic anions, using membrane vesicles, the MgATP dependent transport of 17 p-estradiol-(17-p-D-glucuronide) (E217BG) was ..
  12. Reactive nitrogen species and accelerated atherosclerosis in type I diabetes
    Ming Hui Zou; Fiscal Year: 2013
    ..species such as peroxynitrite (ONOO-) uncouples endothelial nitric oxide synthase (eNOS) {generates superoxide anions (O2...
  13. Modulation of Peripheral Gustatory Neurons by Organic Salts and Organic Acids
    JOSEPH MICHAEL BREZA; Fiscal Year: 2011
    ..Today however, many preservatives in the form of organic Na+ salts, with large anions and organic acids are used in processed foods to increase shelf life, maintain color, and prevent caking, etc...
  14. Oxidized-LDL, LOX-1 and angiogenesis
    Jawahar L Mehta; Fiscal Year: 2013
    ..Among the key events leading to angiogenesis is generation of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide which play a key role in physiological and pathophysiological states...
  15. Using deep-cavity cavitands to study supramolecular chemistry in water
    Bruce C Gibb; Fiscal Year: 2013
    ..Magnetic Resonance (NMR) spectroscopy, we have traced the ability of chaotropes to weaken binding to the fact that anions have a surprisingly strong affinity for hydrophobic concavity...
  16. Dynamic Microdomains in Brain Extracellular Space
    SABINA HRABETOVA; Fiscal Year: 2013
    ..g., calcium) but repulse polyvalent anions, thereby acting as charge discriminators within the DMs...
  17. Pathogen trapping by genital mucus secretions
    JUSTIN S HANES; Fiscal Year: 2013
    ..Aim 3 will investigate the roles of lactic acid, and lactate anions, in causing STD pathogens to be trapped by mucus...
  18. Systems Biology of Anionic Drug and Metabolite Handling
    Sanjay K Nigam; Fiscal Year: 2012
    ..antibiotics, diuretics, ACE inhibitors, NSAIDs) as well as disease-associated metabolites are organic anions that are excreted as a result of transport by the proximal tubule of the kidney...
  19. GENETIC RESPONSE TO OXIDATIVE STREET IN E COLI
    SPENCER FARR; Fiscal Year: 1993
    ..from investigators application) Normal aerobic metabolism produces reactive oxygen species including superoxide anions, hydrogen peroxide and hydroxyl radicals...
  20. CFTR-Ion Conduction and Gating Mechanisms
    David C Dawson; Fiscal Year: 2010
    ..Our recent work suggests new approaches. We have demonstrated that the permeant, pseudohalide anions, [Au(CN)2]- and [Ag(CN)2]- can be locked inside the CFTR pore by means of a ligand substitution reaction...
  21. Design of Modular Receptors for Ion and Molecule Recognition
    DARREN WILLIAM JOHNSON; Fiscal Year: 2013
    ..research program is to design modular organic receptors containing recognition elements that are optimized to bind anions in solution...
  22. Catalytic Methods for Carbon-Carbon and Carbon-Heteroatom Bond Formation
    F D Toste; Fiscal Year: 2013
    ..proposed studies include enantioselective reactions catalyzed by chiral phosphinegold(I) complexes and/or chiral anions. These reactions include enantioselective C-C bond formation through alkyne initiated cyclization cascades or by ..
  23. NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESIS
    MARION CHAN; Fiscal Year: 2004
    ..in turmeric is curcumin, an inhibitor of nitric oxide production and a scavenger of nitric oxide and superoxide anions. Our laboratory has found that curcumin inhibits the gene expression of inducible nitric oxide synthase (iNOS) in ..
  24. Structural correlates of prestin activity.
    JOSEPH R SANTOS-SACCHI; Fiscal Year: 2013
    ..influenced by interactions of prestin's intracellular C and N termini with other intracellular proteins and anions, and possibly by multimeric interactions, as well...
  25. Neonatal Phototherapy / Bilirubin Excretion
    DAVID LIGHTNER; Fiscal Year: 2007
    ..The specific aims are to: 1) Fully characterize the 3-dimensional structure of bilirubin, its anions, conjugates and photoisomers in biomemtic/physiologic environments using molecular dynamics computations and ..
  26. Novel Chelators for Highly Efficient Removal of Toxic Heavy Metals in Humans
    Charles Timchalk; Fiscal Year: 2009
    ..They are also not effective in removing Cd and toxic anions such as chromate and arsenate...
  27. ALKALOID SYNTHESIS VIA (3+2) CYCLOADDITIONS
    BRIAN COPPOLA; Fiscal Year: 2003
    ..The proposed research will attempt to use the anionic (3+2) cycloaddition of 2-azaallyl anions with alkenes and the 1,3-dipolar cycloaddition of azomethine ylides with alkenes for the construction of a cross-..
  28. OXIDATIVE DAMAGE AND IRON REQUIREMENTS OF THE BLASTOCYST
    COLE MANES; Fiscal Year: 1991
    ..in cellular mass during this period of development may make them highly susceptible targets for superoxide anions, peroxides, and hydroxyl radicals...
  29. Protein Stabilization in Ionic Liquids
    Gloria Elliott; Fiscal Year: 2009
    ..Although traditional ILs are synthesized from imidazolium-based actions and highly fluorinated anions, ILs can also be formulated from salts, sugars, amino acids, and biomolecules that exist in nature - many of which ..
  30. Mechanism and Rational Development of Catalytic Carbon-Carbon Bond-Forming Reacti
    John F Hartwig; Fiscal Year: 2013
    ..that mediate the coupling of aryl, vinyl, and allyl electrophiles with enolates, cyanide, trifluoromethyl anions, and main group organometallic reagents with control of absolute stereochemistry in many cases, and 3) new ..
  31. Development of Next Generation Stabilization Agents for Cell based Therapeutics
    Gloria D Elliott; Fiscal Year: 2013
    ..We have also been able to modulate the cytotoxicity of ionic liquids by rational selection of anions. We propose to extend these exciting results to cellular applications, where many of the same features are desired ..
  32. NITRIC OXIDE/SUPEROXIDE IN LIPID VASCULAR DISEASE
    TIMOTHY O BRIEN; Fiscal Year: 2000
    ..NO is generated in the endothelium by eNOS and can be inactivated with superoxide anions. Superoxide anions are scavenged by SOD...
  33. NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESIS
    MARION CHAN; Fiscal Year: 2000
    ..in turmeric is curcumin, an inhibitor of nitric oxide production and a scavenger of nitric oxide and superoxide anions. Our laboratory has found that curcumin inhibits the gene expression of inducible oxide synthase (iNOS) in vitro ..
  34. Expression of MRP2 and OCTI Transporters in the Kidney
    JOHN WELBORN; Fiscal Year: 2001
    ..Transporters mediating secretion can be classified according to their substrates, handling either organic anions (OAs) or organic cations (OCs)...
  35. HEPATIC PATHWAYS OF HEME AND BILIRUBIN METABOLISM
    John Gollan; Fiscal Year: 1999
    ..R.) of an array of small hydrophobic and amphipathic molecules (e.g., organic anions, bile salts, endogenous and xenobiotic substrates)...
  36. REACTIVITY AND SELECTIVITY OF REACTIONS IN POLAR MEDIA
    PAUL GRIECO; Fiscal Year: 2002
    ..In addition we remain focused on anions that are more weakly coordinating than perchlorate. This proposal is divided into three parts...
  37. PROXIMAL COLON--A DISTINCT TRANSPORT EPITHELIUM
    Joseph Sellin; Fiscal Year: 1993
    ..The cecum exhibits a high rate of electrogenic Na absorption, neither coupled to anions or nutrients, nor blocked by amiloride...
  38. 2 + 3 ANNULATION PROTOCOL--NATURAL PRODUCT SYNTHESIS
    Tomas Hudlicky; Fiscal Year: 1992
    ..It is based on either the [2+3] intermolecular addition of ester dienolate anions to carbonyl derivatives (for cyclopentenes and dihydrofurans) or the [4+1] intramolecular addition of azides to ..
  39. REGULATION OF HEPATIC LIPID METABOLISM BY ORGANIC ANIONS
    STEPHEN ZUCKER; Fiscal Year: 2001
    ..Furthermore, advantage will be taken of homozygous Gun rats which either do or do not develop kernicterus although they have the same serum bilirubin levels. In these rats, variations in apo D expression will be studied. ..
  40. EFFECTS OF ETHANOL ON HEPATIC ORGANIC ANION UPTAKE
    Barry Potter; Fiscal Year: 1992
    One of the major functions of the liver is the uptake of low molecular weight organic anions. Three classes of these compounds in particular - bile acids, nonbile acid cholephils such as bilirubin and sulfobromophthalein (BSP), and long-..
  41. PHOSPHATE ANALOG PROBES OF RED CELL METABOLISM
    Richard Labotka; Fiscal Year: 1990
    ..This protein may also help regulate intracellular pH by cotransport of protons with divalent anions. We propose to determine using P-31 NMR spectroscopy the stoicheiometry of the transport of titratable anions, ..
  42. CELLULAR PATHOGENESIS OF PEDIATRIC LIVER DISEASE
    David Perlmutter; Fiscal Year: 2001
    ..are characterized by abnormalities in protein folding and/or cellular trafficking of trace metals and organic anions may also cause the cholestatic liver diseases associated with overload of copper, iron and bile acids...
  43. Catalytic Nucleophilic Glyoxylation: Asymmetric Derivatizations and Aldol/Oxidati
    KIMBERLY MICHELLE STEWARD; Fiscal Year: 2012
    ..proposal aims to develop practical new catalytic reactions that provide the synthetic equivalents of glyoxylate anions to allow the direct incorporation of this substructure into electrophiles...
  44. NEURAL TUBE DEFECTS INDUCED BY ANIONS VIA INCREASED PHI
    Michael Collins; Fiscal Year: 1991
    Specific organic aliphatic monocarboxylic acids (or their anions), such as the anticonvulsant valproic acid or the metabolites of environmental contaminants, 2-methoxyacetic acid and 2-ethylhexanoic acid, are teratogenic in more than a ..
  45. ONTOGENY OF HEPATIC ION TRANSPORT
    Frederick Suchy; Fiscal Year: 2007
    ..mechanisms underlying the expression of basolateral and canalicular transporters for bile acids and other organic anions during development and cholestatic liver disease...
  46. MOLECULAR ORGANIZATION OF ION CHANNELS--A NOVEL APPROACH
    Anatoli Lopatin; Fiscal Year: 1999
    ..individual potassium channels to produce specific, weakly soluble, inorganic microcrystals with some halide anions and transition metals at the exact location of the channel pore...
  47. IONIC ACTIVITIES IN BIOLOGICAL AND SALINE MEDIA
    Rabindra Roy; Fiscal Year: 1992
    ..of reasonable self- consistent scales and reference standards for the activities of the common cations and anions in biological and saline media, and the application of these results in refining procedures for the determination ..
  48. POLYMER MEMBRANE ION/POLYION SENSORS--NEW FRONTIERS
    MARK MEYERHOFF; Fiscal Year: 2001
    ..plasticized polymeric films containing appropriate lipophilic ion-exchangers as well as selective interactions of anions with given metal ion-ligand complexes to devise sensors that will enable the direct detection of biomedically ..
  49. MECHANISMS OF HEPATIC FATTY ACID TRANSPORT
    PAUL BERK; Fiscal Year: 2001
    DESCRIPTION: The long term goal of this program is to understand the hepatocellular uptake of albumin-bound organic anions such as free fatty acids. This proposal examines how mAspAT functions as an FFA transporter...
  50. SYNTHESIS AND ANTITUMOR ACTIVITY OF TERPENOIDS
    Duy Hua; Fiscal Year: 1991
    ..in the studies of the regioselectivity and mechanism of the asymmetric addition reactions of chiral sulfinylallyl anions and allylphosphonyl anions with enones, and the subsequent cyclizations to produce chiral indolizidines, ..
  51. Multiple Mechanisms of Hepatoprotective Mrp3 Induction
    Nathan Cherrington; Fiscal Year: 2005
    ..Mrp3, which is localized to the sinusoidal membrane of hepatocytes, exports a wide range of I organic anions from the liver, into the blood...
  52. HEMOGLOBIN BASED OXYGEN CARRIERS
    Enrico Bucci; Fiscal Year: 1991
    ..investigated for its peculiar functional characteristics namely the strong sensitivity of its oxygen affinity to anions and the relative insensitivity to polyphosphates...
  53. MECHANISM OF TUBULAR SECRETION OF ORGANIC ANIONS
    JAMES GOLDINGER; Fiscal Year: 1991
    The renal proximal tubule actively secretes many organic anions, including anionic metabolites and drugs...
  54. Enantioselective Synthesis by Chiral Anion Phase Transfer Catalysis
    F D Toste; Fiscal Year: 2013
    ..as electrophiles towards heteroatom and carbon-based nucleophiles, by coordination phosphate-derived chiral anions in the presence of cationic electrophiles...
  55. IRON BINDING PROTEINS AND CONTROL OF IRON METABOLISM
    Philip Aisen; Fiscal Year: 2001
    ..Since iron release is also sensitive to binding of simple anions by transferrin, this work also investigates the kinetically active sites on transferrin which respond to these ..
  56. Effect Of Stress On Vascular NOS In Aged
    LESLIE FUCHS; Fiscal Year: 2004
    ..In old BHR, behavioral stress decreases NOS-dependent relaxation due to an increase in superoxide anions and a decrease in expression and/or function of BKCa channels...
  57. PATHOGENESIS OF CONGENITAL MURINE CYSTIC NEPHROGENESIS
    Ellis Avner; Fiscal Year: 1992
    ..Na-K ATPase activity; b) proximal tubular epithelial hyperplasia and increased transtubular transport of organic anions occur in relation to such increases in enzyme activity; and c) fluid secretion obligated by the net intratubular ..
  58. CHLORIDE AND OSMOLYTES AND VOLUME REGULATION
    SARAH GARBER; Fiscal Year: 1999
    ..fluorescent and confocal microscopy and molecular biology techniques to address the physiological role of anions, osmolytes and the cytoskeleton in volume regulation...
  59. SULFINYL KETIMINES
    Duy Hua; Fiscal Year: 1992
    ..The anions of these ketimines undergo in situ 1,4-addition/ring closure reactions with alpha-ene esters, 1,3-diiodopropane, ..
  60. TRANSPORT ATPASE--ENERGY COUPLING
    Parjit Kaur; Fiscal Year: 1999
    ..Upon interaction, the ArsA and the ArsB proteins form a functional pump to extrude the anions out of the cell...
  61. Hepatoprotective Mrp3
    Nathan Cherrington; Fiscal Year: 2009
    ..Mrp3, which is normally expressed at low levels, serves to export a wide range of organic anions from the liver, back to the blood, thereby decreasing their exposure and toxicity to the liver...
  62. Chiral Ionic Liquid Solvents for Asymmetric Synthesis
    ELENA KRUMENAKER; Fiscal Year: 2007
    ..Phase I project will investigate newly discovered ionic liquids (IL's) that are based on asymmetric organic anions for use as environmentally friendly, VOC-free "green" solvents including four new room-temperature ionic liquids (..
  63. SIGNAL TRANSDUCTION IN NEUTROPHIL MEDIATED HEART INJURY
    Julian Gomez Cambronero; Fiscal Year: 2002
    ..Neutrophils release lethal oxygen radicals (such as superoxide anions) that are capable of exacerbating tissue damage, as encountered after the infiltration of these cells during post-..