chlorides

Summary

Summary: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.

Top Publications

  1. ncbi Cation-chloride cotransporters and neuronal function
    Peter Blaesse
    Department of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1, FIN 00014, Helsinki, Finland
    Neuron 61:820-38. 2009
  2. ncbi TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity
    Antonella Caputo
    Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genova 16148, Italy
    Science 322:590-4. 2008
  3. ncbi TMEM16A confers receptor-activated calcium-dependent chloride conductance
    Young Duk Yang
    Sensory Research Center, CRI, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Nature 455:1210-5. 2008
  4. pmc Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
    Fredrick Van Goor
    Vertex Pharmaceuticals Incorporated, 11010 Torreyana Road, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 106:18825-30. 2009
  5. pmc Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation
    Frank J Accurso
    University of Colorado Denver and Children s Hospital, Aurora, CO 80045, USA
    N Engl J Med 363:1991-2003. 2010
  6. ncbi Roles of the cation-chloride cotransporters in neurological disease
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Nat Clin Pract Neurol 4:490-503. 2008
  7. pmc Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle
    Liang Feng
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA
    Science 330:635-41. 2010
  8. pmc TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A
    Joana Almaca
    Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31, D 93053 Regensburg, Germany
    J Biol Chem 284:28571-8. 2009
  9. ncbi The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    C Rivera
    Department of Biosciences, University of Helsinki, Finland
    Nature 397:251-5. 1999
  10. pmc Chloride channels as drug targets
    Alan S Verkman
    Departments of Medicine and Physiology, University of California, San Francisco, California 94143 0521, USA
    Nat Rev Drug Discov 8:153-71. 2009

Research Grants

  1. System for Decontaminating Well Water for Drinking
    GIRISH SRINIVAS; Fiscal Year: 2010
  2. BIOLOGICALLY ACTIVE CYCLIC PEPTIDES
    Dale L Boger; Fiscal Year: 2013
  3. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2013
  4. Highly Active Palladium Catalysts for Organic Synthesis
    Qiao Sheng Hu; Fiscal Year: 2004
  5. SILOXANE COUPLINGS AND NATURAL PRODUCT SYNTHESIS
    Philip DeShong; Fiscal Year: 2001
  6. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
  7. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
  8. Divalent Metal Transporter: Role in Manganese Toxicity
    JEROME ROTH; Fiscal Year: 2004
  9. Regulation of Pendrin by Angiotensin II
    Susan Wall; Fiscal Year: 2007
  10. Designing HTA therapy for drug resistant malaria
    Christian Wolf; Fiscal Year: 2009

Detail Information

Publications359 found, 100 shown here

  1. ncbi Cation-chloride cotransporters and neuronal function
    Peter Blaesse
    Department of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1, FIN 00014, Helsinki, Finland
    Neuron 61:820-38. 2009
    ..The rapidly expanding work on CCCs promotes our understanding of fundamental mechanisms that control brain development and functions under normal and pathophysiological conditions...
  2. ncbi TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity
    Antonella Caputo
    Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genova 16148, Italy
    Science 322:590-4. 2008
    ....
  3. ncbi TMEM16A confers receptor-activated calcium-dependent chloride conductance
    Young Duk Yang
    Sensory Research Center, CRI, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Nature 455:1210-5. 2008
    ..We conclude that ANO1 is a candidate Ca(2+)-activated chloride channel that mediates receptor-activated chloride currents in diverse physiological processes...
  4. pmc Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
    Fredrick Van Goor
    Vertex Pharmaceuticals Incorporated, 11010 Torreyana Road, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 106:18825-30. 2009
    ..These results support the hypothesis that pharmacological agents that restore or increase CFTR function can rescue epithelial cell function in human CF airway...
  5. pmc Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation
    Frank J Accurso
    University of Colorado Denver and Children s Hospital, Aurora, CO 80045, USA
    N Engl J Med 363:1991-2003. 2010
    ..VX-770, a CFTR potentiator, has been shown to increase the activity of wild-type and defective cell-surface CFTR in vitro...
  6. ncbi Roles of the cation-chloride cotransporters in neurological disease
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Nat Clin Pract Neurol 4:490-503. 2008
    ..CCCs represent attractive therapeutic targets in neurological disorders the pathogenesis of which involves deranged cellular chloride homoestasis...
  7. pmc Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle
    Liang Feng
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA
    Science 330:635-41. 2010
    ..Comparison with prokaryotic CLC shows that a gating glutamate residue changes conformation and suggests a basis for 2:1 Cl(-)/H(+) exchange and a simple mechanistic connection between CLC channels and transporters...
  8. pmc TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A
    Joana Almaca
    Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31, D 93053 Regensburg, Germany
    J Biol Chem 284:28571-8. 2009
    ..Thus TMEM16 proteins appear to be a crucial component of epithelial volume-regulated Cl(-) channels and may also have a function during proliferation and apoptotic cell death...
  9. ncbi The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    C Rivera
    Department of Biosciences, University of Helsinki, Finland
    Nature 397:251-5. 1999
    ..These data support the conclusion that KCC2 is the main Cl- extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain...
  10. pmc Chloride channels as drug targets
    Alan S Verkman
    Departments of Medicine and Physiology, University of California, San Francisco, California 94143 0521, USA
    Nat Rev Drug Discov 8:153-71. 2009
    ..Here, we discuss the broad opportunities that remain in chloride-channel-based drug discovery...
  11. ncbi Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy
    Gilles Huberfeld
    INSERM U739, Faculté de Médecine Pitié Salpêtrière, Universite Pierre et Marie Curie Paris 6, IFR70, CHU Pitie Salpetriere, 75013 Paris, France
    J Neurosci 27:9866-73. 2007
    ..Changes in Cl- transporter expression thus contribute to human epileptiform activity, and molecules acting on these transporters may be useful antiepileptic drugs...
  12. pmc Expression and function of epithelial anoctamins
    Rainer Schreiber
    Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31, D 93053 Regensburg, Germany
    J Biol Chem 285:7838-45. 2010
    ..We conclude that each tissue expresses a set of anoctamins that form cell- and tissue-specific Ca(2+)-dependent Cl(-) channels...
  13. ncbi Environmental genomics reveals a functional chlorite dismutase in the nitrite-oxidizing bacterium 'Candidatus Nitrospira defluvii'
    Frank Maixner
    Department für Mikrobielle Okologie, Universitat Wien, Vienna, Austria
    Environ Microbiol 10:3043-56. 2008
    ....
  14. ncbi Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter
    D B Simon
    Howard Hughes Medical Institute, Department of Genetics, Boyer Center for Molecular Medicine, New Haven, Connecticut, USA
    Nat Genet 12:24-30. 1996
    ..We speculate that these mutant alleles lead to reduced sodium chloride reabsorption in the more common heterozygotes, potentially protecting against development of hypertension...
  15. ncbi WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1
    Tetsuo Moriguchi
    Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, and CREST, JST, Chiyoda, Tokyo 101 0062
    J Biol Chem 280:42685-93. 2005
    ..These results suggested that WNK1 and SPAK/OSR1 mediate the hypotonic stress signaling pathway to the transporters and may provide insights into the mechanisms by which WNK1 regulates ion balance...
  16. ncbi Synaptically activated Cl- accumulation responsible for depolarizing GABAergic responses in mature hippocampal neurons
    Y Isomura
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 90:2752-6. 2003
    ..This may be the first demonstration of microscopic visualization of intracellular Cl- accumulation during synaptic activation...
  17. ncbi Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH
    Jayasankar Jasti
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Nature 449:316-23. 2007
    ....
  18. pmc Unexpected diversity of chlorite dismutases: a catalytically efficient dimeric enzyme from Nitrobacter winogradskyi
    Georg Mlynek
    Department for Structural and Computational Biology, Max F Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, A 1030 Vienna, Austria
    J Bacteriol 193:2408-17. 2011
    ..Interestingly, proteins that contain all these signatures and are phylogenetically closely related to the novel-type Cld of N. winogradskyi exist in a large number of other microbes, including other nitrite oxidizers...
  19. ncbi Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis
    Sarah A Hewitt
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Neurosci 12:438-43. 2009
    ..Our data indicate that hypothalamic neurons integrate psychological cues to mount the endocrine response to stress by regulating anion gradients...
  20. pmc Cystic fibrosis: terminology and diagnostic algorithms
    K De Boeck
    Department of Pediatrics, Pediatric Pulmonology, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Thorax 61:627-35. 2006
    ..Non-classic CF includes patients with multiorgan or single organ involvement. Most of these patients have exocrine pancreatic sufficiency and milder lung disease. Algorithms for a structured diagnostic process are proposed...
  21. ncbi Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective phase II trial
    Eitan Kerem
    Hadassah Hebrew University Hospital, Jerusalem, Israel
    Lancet 372:719-27. 2008
    ..PTC124 is an orally bioavailable small molecule that is designed to induce ribosomes to selectively read through premature stop codons during mRNA translation, to produce functional CFTR...
  22. ncbi Altered chloride homeostasis in neurological disorders: a new target
    Yves De Koninck
    Unite de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, 2601 chemin de la Canardière, Quebec, G1J 2G3, Canada
    Curr Opin Pharmacol 7:93-9. 2007
    ..These findings, together with the observation of altered chloride homeostasis in several neurological disorders, point to new targets for therapeutic agents...
  23. ncbi Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A
    Yuemin Tian
    Institut fur Physiologie, Universitat Regensburg, Universitätsstraße 31, D 93053 Regensburg, Germany
    FASEB J 25:1058-68. 2011
    ..These results reinforce the use of these compounds for activation of electrolyte secretion in diseases such as cystic fibrosis...
  24. pmc Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport
    Jiraporn Ousingsawat
    Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31, D 93053 Regensburg, Germany
    J Biol Chem 284:28698-703. 2009
    ..These results clearly demonstrate the broad physiological role of TMEM16A(-/-) for Ca(2+)-dependent Cl(-) secretion and provide the basis for novel treatments in cystic fibrosis, infectious diarrhea, and Sjöegren syndrome...
  25. ncbi Green fluorescent protein-based halide indicators with improved chloride and iodide affinities
    L J Galietta
    Department of Medicine, Cardiovascular Research Institute, 1246 Health Sciences East Tower, University of California, San Francisco, CA 94143-0521, USA
    FEBS Lett 499:220-4. 2001
    ..The anion-sensitive mechanism of these indicators was established and their utility in cells was demonstrated using transfected cells expressing the cystic fibrosis transmembrane conductance regulator chloride channel...
  26. pmc Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells
    Victor G Romanenko
    Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 285:12990-3001. 2010
    ....
  27. ncbi Mechanisms of Cl(-) transport contributing to salt tolerance
    Natasha L Teakle
    Centre for Ecohydrology and Future Farm Industries CRC, The University of Western Australia, Crawley, Australia
    Plant Cell Environ 33:566-89. 2010
    ..This review integrates current knowledge of Cl(-) transport mechanisms to identify future pathways for improving salt tolerance...
  28. pmc Chloride conductance and genetic background modulate the cystic fibrosis phenotype of Delta F508 homozygous twins and siblings
    I Bronsveld
    Department of Pediatrics, Sophia Children s Hospital, Rotterdam, The Netherlands
    J Clin Invest 108:1705-15. 2001
    ..The more concordant Cl(-) secretory patterns within monozygous twins compared with dizygous pairs imply that genes other than CFTR significantly influence the manifestation of the basic defect...
  29. pmc Understanding the roles of strictly conserved tryptophan residues in O2 producing chlorite dismutases
    Béatrice Blanc
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46656, USA
    Dalton Trans 42:3156-69. 2013
    ..These observations and the lack of redox protection for the heme in any of the Trp mutants suggests a tendency for protein radical formation in DaCld that is independent of any of these conserved active site residues...
  30. ncbi Comparison of vectorial ion transport in primary murine airway and human sinonasal air-liquid interface cultures, models for studies of cystic fibrosis, and other airway diseases
    Shaoyan Zhang
    Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Rhinol Allergy 23:149-52. 2009
    ..Our hypothesis is that murine septal epithelium, rather than trachea, will more closely mimic the electrophysiology properties of human sinonasal epithelium...
  31. pmc Molecular components of signal amplification in olfactory sensory cilia
    Thomas Hengl
    Department of Molecular Physiology, University of Heidelberg, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 107:6052-7. 2010
    ..They provide a molecular concept for the unique strategy that allows olfactory sensory neurons to operate as efficient transducers of weak sensory stimuli...
  32. pmc Structure of a slow CLC Cl⁻/H+ antiporter from a cyanobacterium
    Hariharan Jayaram
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, United States
    Biochemistry 50:788-94. 2011
    ..SY thus shares a similar structure and a common transport mechanism to EC, but it is by comparison slow, a result that refutes the idea that the transport mechanism of CLCs leads to intrinsically high rates...
  33. ncbi Fluid transport and cystogenesis in autosomal dominant polycystic kidney disease
    Sara Terryn
    Division of Nephrology, Université Catholique de Louvain Medical School, B 1200, Brussels, Belgium
    Biochim Biophys Acta 1812:1314-21. 2011
    ..This article is part of a Special Issue entitled: Polycystic Kidney Disease...
  34. pmc Bestrophin-1 enables Ca2+-activated Cl- conductance in epithelia
    Rene Barro Soria
    Institut fur Physiologie, Universitat Regensburg, Universitätsstrabetae 31, D 93053 Regensburg, Germany
    J Biol Chem 284:29405-12. 2009
    ..Calcium-dependent Cl(-) currents were activated by ATP in HEK293 cells expressing BEST1. Thus, BEST1 may form the Ca2+-activated Cl(-) current, or it may be a component of a Cl(-) channel complex in epithelial tissues...
  35. ncbi New insights into fish ion regulation and mitochondrion-rich cells
    Pung Pung Hwang
    Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, 115, Taiwan
    Comp Biochem Physiol A Mol Integr Physiol 148:479-97. 2007
    ..Several new windows have been opened particularly in terms of molecular mechanisms of ionocyte differentiation and energy metabolite transport between gill cells during environmental challenge...
  36. ncbi The chloride transporter Na(+)-K(+)-Cl- cotransporter isoform-1 contributes to intracellular chloride increases after in vitro ischemia
    Brooks B Pond
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 26:1396-406. 2006
    ..We conclude that NKCC-1 plays an important role in OGD-induced Cl- accumulation and subsequent neuronal damage...
  37. pmc Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger
    Alessandra Picollo
    Department of Anesthesiology, Weill Cornell Medical College, New York, New York, USA
    Nat Struct Mol Biol 19:525-31, S1. 2012
    ..We propose that the thermodynamics of synergistic substrate binding, rather than the kinetics of conformational changes and ion binding, determine the stoichiometry of transport...
  38. ncbi Sodium instead of potassium and chloride is an important macronutrient to improve leaf succulence and shoot development for halophyte Sesuvium portulacastrum
    Dongyang Wang
    Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China
    Plant Physiol Biochem 51:53-62. 2012
    ..portulacastrum...
  39. pmc Measurements of CFTR-mediated Cl- secretion in human rectal biopsies constitute a robust biomarker for Cystic Fibrosis diagnosis and prognosis
    Marisa Sousa
    BioFIG Centre for Biodiversity, Functional and Integrative Genomics, Faculty of Sciences, University of Lisboa, Lisboa, Portugal
    PLoS ONE 7:e47708. 2012
    ..Clinical features are dominated by respiratory symptoms, but there is variable organ involvement thus causing diagnostic dilemmas, especially for non-classic cases...
  40. pmc TMEM16A channels generate Ca²⁺-activated Cl⁻ currents in cerebral artery smooth muscle cells
    Candice Thomas-Gatewood
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 301:H1819-27. 2011
    ..In summary, these data indicate that TMEM16A channels are expressed, insert into the plasma membrane, and generate Cl(Ca) currents in cerebral artery SMCs...
  41. ncbi Mechanism of chloride interaction with neurotransmitter:sodium symporters
    Elia Zomot
    Department of Biochemistry, Hebrew University Hadassah Medical School, POB 12272, Jerusalem 91120, Israel
    Nature 449:726-30. 2007
    ....
  42. pmc Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis
    E Maeno
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Proc Natl Acad Sci U S A 97:9487-92. 2000
    ..Thus, it is concluded that the AVD, which is caused by disordered cell volume regulation, is an early prerequisite to apoptotic events leading to cell death...
  43. ncbi ClC-3 chloride channel prevents apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through mitochondria dependent pathway
    Yan Qian
    Department of Pharmacology, Cardiac and Cerebrovascular Research Center, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, People s Republic of China
    Apoptosis 16:468-77. 2011
    ..Our data suggest that ClC-3 Cl(-) channel can modulate H(2)O(2)-induced apoptosis in BASMCs via the intrinsic, mitochondrial pathway...
  44. ncbi Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers
    André M Cantin
    Pulmonary Research Unit, Faculty of Medicine, Universite de Sherbrooke, 3001, 12ième Avenue Nord, Sherbrooke, Quebec, J1H 5N4 Canada
    Am J Respir Crit Care Med 173:1139-44. 2006
    ..Cigarette smoke extract inhibits chloride secretion in human bronchial epithelial cells. Oxidants decrease gene expression, protein expression, and function of the cystic fibrosis transmembrane conductance regulator (CFTR)...
  45. ncbi Kinetic properties of Cl uptake mediated by Na+-dependent K+-2Cl cotransport in immature rat neocortical neurons
    Katharina Achilles
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, 55128 Mainz, Germany
    J Neurosci 27:8616-27. 2007
    ....
  46. ncbi Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca(2+)-dependent K+ channel
    D C Devor
    Department of Cell Biology and Physiology, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 271:L775-84. 1996
    ..1-EBIO is the first pharmacological opener of this important class of epithelial K+ channels to be identified...
  47. pmc Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents
    Mirko Moroni
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 31:14095-106. 2011
    ..These observations suggest that permeant chloride affects gating by a foot-in-the-door effect, binding to a channel site with asymmetrical access from the intracellular and extracellular sides of the membrane...
  48. ncbi Reductive dehalogenation mediated initiation of aerobic degradation of 2-chloro-4-nitrophenol (2C4NP) by Burkholderia sp. strain SJ98
    Janmejay Pandey
    Institute of Microbial Technology CSIR, Sector 39 A, Chandigarh, 160036, India
    Appl Microbiol Biotechnol 92:597-607. 2011
    ....
  49. ncbi Bond strengths of two adhesive systems to dentin contaminated with a hemostatic agent
    Watcharaporn Kuphasuk
    Department of Operative Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
    Oper Dent 32:399-405. 2007
    ..The bond strength of CB20 to contaminated dentin was significantly lower than that to normal dentin. The extension of primer application time from 20 to 40 seconds significantly increased the bond strength of CB to contaminated dentin...
  50. ncbi Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea
    Rainer Schreiber
    Institut fur Physiologie, Universitat Regensburg, Germany
    Cell Physiol Biochem 16:99-108. 2005
    ..In summary, activation of luminal P2Y6 receptors in the airways shifts electrolyte transport towards secretion by increasing intracellular Ca+ and activation of PKA...
  51. pmc Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport
    Patricia Preston
    Leibniz Institut für Molekulare Pharmakologie and Max Delbrück Centrum für Molekulare Medizin, 13125 Berlin, Germany
    J Biol Chem 285:7165-75. 2010
    ..Further, these results suggest KCNE3 as a potential modifier gene in cystic fibrosis...
  52. pmc DeltaF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers
    S M Rowe
    Department of Medicine, University of Alabama at Birmingham, 1530 3rd Ave South, Birmingham, AL 35294 0005, United States
    Pulm Pharmacol Ther 23:268-78. 2010
    ..The results identify important differences in DeltaF508 CFTR activation in polarizing epithelial models of CF, and have important implications regarding detection of rescued of DeltaF508 CFTR in vivo...
  53. pmc Hesperidin stimulates cystic fibrosis transmembrane conductance regulator-mediated chloride secretion and ciliary beat frequency in sinonasal epithelium
    Christopher Azbell
    Department of Surgery Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, AL, USA
    Otolaryngol Head Neck Surg 143:397-404. 2010
    ....
  54. ncbi Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon
    Jens Duebel
    Department of Biomedical Optics, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Neuron 49:81-94. 2006
    ..Blockers of Cl(-) transporters reduced the somatodendritic [Cl(-)](i) gradient. Hence, our results support the idea that ON bipolar cells employ a somatodendritic [Cl(-)](i) gradient to invert GABAergic horizontal cell input...
  55. pmc Gating of CFTR by the STAS domain of SLC26 transporters
    Shigeru B H Ko
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
    Nat Cell Biol 6:343-50. 2004
    ..These findings provide a new understanding of epithelial chloride and bicarbonate transport and may have important implications for both cystic fibrosis and diseases associated with SLC26T...
  56. pmc Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells
    Renaud Robert
    Institut de Physiologie et Biologie Cellulaires, CNRS UMR 6187, Universite de Poitiers, France
    J Physiol 568:483-95. 2005
    ..To our knowledge this study is the first to report the phenotypic consequences of the loss of a Cl(-) channel on vascular reactivity...
  57. ncbi Astrocytes from Na(+)-K(+)-Cl(-) cotransporter-null mice exhibit absence of swelling and decrease in EAA release
    Gui Su
    Department of Neurosurgery, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Am J Physiol Cell Physiol 282:C1147-60. 2002
    ..Our study suggests that stimulation of NKCC1 is required for high-[K(+)](o)-induced swelling, which contributes to glutamate release from astrocytes under high [K(+)](o)...
  58. ncbi Intestinal current measurement for diagnostic classification of patients with questionable cystic fibrosis: validation and reference data
    Nico Derichs
    Cystic Fibrosis Centre, Department of Pediatric Pulmonology and Neonatology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Thorax 65:594-9. 2010
    ..CF transmembrane conductance regulator (CFTR)-mediated ion transport can be studied ex vivo in rectal biopsies by intestinal current measurement (ICM)...
  59. ncbi Cloning, characterization, and chromosomal location of a novel human K+-Cl- cotransporter
    K Hiki
    Department of Human Immunology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science and University of Adelaide, Adelaide, South Australia 5000
    J Biol Chem 274:10661-7. 1999
    ..Radiation hybrid analysis placed KCC3 within an area associated with juvenile myoclonic epilepsy. These results suggest KCC3 is a new member of the KCC family that is under distinct regulation from KCC1...
  60. pmc The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle
    S M Valenzuela
    Centre for Immunology, St Vincent s Hospital and The University of New South Wales, Sydney, NSW, Australia
    J Physiol 529:541-52. 2000
    ..These data strongly support the hypothesis that NCC27 is involved, in some as yet undetermined manner, in regulation of the cell cycle...
  61. ncbi Purification and characterization of chlorite dismutase: a novel oxygen-generating enzyme
    C G van Ginkel
    Akzo Nobel Central Research, Analytical and Environmental Chemistry Department, Velperweg 76, 6800 SB Arnhem, The Netherlands
    Arch Microbiol 166:321-6. 1996
    ..The enzyme was red-colored and had a Soret peak at 392 nm. Per subunit, it contained 0.9 molecule of protoheme IX and 0.7 molecule of iron. Chlorite dismutase displayed maxima for activity at pH 6.0 and 30 degrees C...
  62. pmc Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis
    Mirjam Moviat
    Department of Intensive Care Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Crit Care 7:R41-5. 2003
    ..Metabolic acidosis is the most frequent acid-base disorder in the intensive care unit. The optimal analysis of the underlying mechanisms is unknown...
  63. ncbi Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells
    R Tonini
    Dipartimento di Fisiologia e Biochimica Generali, I Università di Milano, 20133 Milano, Italy
    FASEB J 14:1171-8. 2000
    ..We conclude that despite its relatively small size, NCC27 must form an integral part of an ion channel complex...
  64. pmc Mutations in the cystic fibrosis transmembrane regulator gene and in vivo transepithelial potentials
    Michael Wilschanski
    The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Am J Respir Crit Care Med 174:787-94. 2006
    ..To examine the relationship between cystic fibrosis transmembrane regulator gene mutations (CFTR) and in vivo transepithelial potentials...
  65. ncbi Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme
    Ramanathan Natesh
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 43:8718-24. 2004
    ....
  66. ncbi Salt tolerance in wild Hordeum species is associated with restricted entry of Na+ and Cl- into the shoots
    Alaina J Garthwaite
    School of Plant Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Exp Bot 56:2365-78. 2005
    ..Thus, several salt-tolerant wild Hordeum species were identified, and these showed an exceptional capacity to 'exclude' Na+ and Cl- from their shoots...
  67. pmc Cl- uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1
    Junko Yamada
    Department of Biological Information Processing, Graduate School of Electronic Science and Technology, Shizuoka University, Hamamatsu, Shizuoka 432 8011, Japan
    J Physiol 557:829-41. 2004
    ..These data suggest that NKCC1 may play a pivotal role in the generation of GABA-mediated depolarization in immature CP cells, while KCC2 promotes the later maturation of GABAergic inhibition in the rat neocortex...
  68. pmc Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis
    Nicolas Doyon
    Division of Cellular and Molecular Neuroscience, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec, Canada
    PLoS Comput Biol 7:e1002149. 2011
    ....
  69. ncbi Brain-type creatine kinase activates neuron-specific K+-Cl- co-transporter KCC2
    Koichi Inoue
    Department of Physiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    J Neurochem 96:598-608. 2006
    ..In primary cortical neurons expressing CKB, the GABA reversal potential was also shifted in the depolarizing direction by DNFB. Our findings suggest that, in the cellular micro-environment, CKB activates the KCC2 function...
  70. ncbi Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel
    Ricardo de la Fuente
    1246 Health Sciences East Tower, Box 0521, University of California, San Francisco CA 94143 0521, USA
    Mol Pharmacol 73:758-68. 2008
    ..Small-molecule CaCC inhibitors may be useful in pharmacological dissection of CaCC functions and in reducing intestinal fluid losses in CaCC-mediated secretory diarrheas...
  71. ncbi Development of cystic fibrosis and noncystic fibrosis airway cell lines
    Joseph Zabner
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 284:L844-54. 2003
    ..These cell lines should therefore be useful as models for studying ion physiology, therapeutic intervention for CF, and innate immunity...
  72. ncbi Physiological and behavioural responses of Gammarus pulex (Crustacea: Amphipoda) exposed to cadmium
    V Felten
    Laboratoire d Ecotoxicologie, Cemagref, 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09, France
    Aquat Toxicol 86:413-25. 2008
    ..The results of this study indicate that osmolality and locomotor activity in G. pulex could be effective ecophysiological/behavioural markers to monitor freshwater ecosystem and to assess the health of organisms...
  73. pmc Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures
    Joseph Glykys
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02144, USA
    Neuron 63:657-72. 2009
    ..Regional differences in the ontogeny of Cl(-) transport may thus explain why seizure activity in the cortex is not suppressed by anticonvulsants that block the transmission of seizure activity through subcortical networks...
  74. ncbi Escherichia coli acid resistance: tales of an amateur acidophile
    John W Foster
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA
    Nat Rev Microbiol 2:898-907. 2004
    ..Surprisingly, certain microorganisms that grow at neutral pH have elegantly regulated systems that enable survival during excursions into acidic environments. The best-characterized acid-resistance system is found in E. coli...
  75. ncbi Noninvasive measurement of chloride concentration in rat olfactory receptor cells with use of a fluorescent dye
    H Kaneko
    Department of Applied Physics and Chemistry, Division of Bio-Informatics, The University of Electro-Communications, Chofu, Tokyo 182 - 8585, Japan
    Am J Physiol Cell Physiol 280:C1387-93. 2001
    ..They provide a starting point for the decrease in ciliary [Cl(-)] predicted to occur during transduction...
  76. pmc The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus
    Tero Viitanen
    Department of Biosciences, PO Box 65, FI 00014 University of Helsinki, Helsinki, Finland
    J Physiol 588:1527-40. 2010
    ..Our findings reveal a novel excitatory mode of action of KCC2 that can have substantial implications for the role of GABAergic transmission during ictal epileptiform activity...
  77. pmc Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy
    Hemal R Pathak
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:14012-22. 2007
    ..This pathophysiological process may constitute a significant mechanism linking injury to the subsequent development of epilepsy...
  78. ncbi A predictable gingival retraction system
    Christopher Pescatore
    Compend Contin Educ Dent 23:7-12; quiz 18. 2002
    ..This article demonstrates the use of this paste retraction system to control tissue for impression making as well as for the insertion of adhesively placed nonmetal restorations...
  79. pmc CLC channels and transporters: proteins with borderline personalities
    Alessio Accardi
    Department of Molecular Physiology and Biophysics, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biochim Biophys Acta 1798:1457-64. 2010
    ..This review focuses on the recent mechanistic insights on the how the structural similarities between CLC channels and transporters translate in unexpected mechanistic analogies between these two sub-classes...
  80. ncbi An excitatory amino-acid transporter with properties of a ligand-gated chloride channel
    W A Fairman
    Howard Hughes Medical Institute, Oregon Health Sciences University, Portland 97201, USA
    Nature 375:599-603. 1995
    ..Thus EAAT4 combines the re-uptake of neurotransmitter with a mechanism for increasing chloride permeability, both of which could regulate excitatory neurotransmission...
  81. ncbi Bond strength of composite to astringent-contaminated dentin using self-etching adhesives
    Kathy L O'Keefe
    Department of Restorative Dentistry and Biomaterials, The University of Texas Dental Branch at Houston, 6516 M D Anderson Blvd, Houston, Texas 77030, USA
    Am J Dent 18:168-72. 2005
    ..To determine the effects of contamination by ferric sulfate and aluminum chloride astringents on the bond strength of composite bonded to superficial dentin using self-etching adhesives...
  82. ncbi Partial correction of defective Cl(-) secretion in cystic fibrosis epithelial cells by an analog of squalamine
    C Jiang
    Genzyme Corporation, Framingham, Massachusetts 01701-9322, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1164-72. 2001
    ..Together, these results demonstrate that in CF airway epithelial cells, administration of GL-172 is capable of partially correcting the defective Cl(-) secretion...
  83. ncbi Ex vivo CF diagnosis by intestinal current measurements (ICM) in small aperture, circulating Ussing chambers
    Hugo R de Jonge
    Departments of Paediatric Gastroenterology and Biochemistry, Erasmus University Medical Centre, P O Box 1738, Rotterdam, 3000DR The Netherlands
    J Cyst Fibros 3:159-63. 2004
    ..ICM is particularly useful for the classification of individuals with CF-like clinical features with equivocal sweat test values and/or no or one identifiable CFTR mutation...
  84. pmc Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
    Christopher S Rogers
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 321:1837-41. 2008
    ..The pig model may provide opportunities to address persistent questions about CF pathogenesis and accelerate discovery of strategies for prevention and treatment...
  85. ncbi Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation
    Stefanie Weinert
    Leibniz Institut fur Molekulare Pharmakologie FMP, 13125 Berlin, Germany
    Science 328:1401-3. 2010
    ..This conductance was even deleterious in Clcn7(+/unc) mice. Clcn7(-/-) and Clcn7(unc/unc) mice accumulated less Cl- in lysosomes than did wild-type mice. Thus, lowered lysosomal chloride may underlie their common phenotypes...
  86. ncbi Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis
    Gaia Novarino
    Leibniz Institut für Molekulare Pharmakologie FMP and Max Delbrück Centrum für Molekulare Medizin MDC, 13125 Berlin, Germany
    Science 328:1398-401. 2010
    ..However, their proximal tubular endocytosis was also impaired. Thus, endosomal chloride concentration, which is raised by ClC-5 in exchange for protons accumulated by the H+-ATPase, may play a role in endocytosis...
  87. ncbi Diverse synaptic mechanisms generate direction selectivity in the rabbit retina
    W Rowland Taylor
    John Curtin School of Medical Research and Centre for Visual Sciences, Australian National University, Canberra, 2601 ACT, Australia
    J Neurosci 22:7712-20. 2002
    ..The results indicate that, within a single neuron, different strategies are used within distinct dendritic arbors to accomplish the same neural computation...
  88. ncbi Curcumin improves learning and memory ability and its neuroprotective mechanism in mice
    Rui Pan
    Department of Orthopedics, The First Affiliated Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China
    Chin Med J (Engl) 121:832-9. 2008
    ..In this study, we observed the memory improving properties of curcumin in mice and investigated the neuroprotective effect of curcumin in vitro and in vivo...
  89. pmc Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2
    Csaba Földy
    Department of Anatomy and Neurobiology, University of California, Irvine, California, USA
    Nat Neurosci 13:1047-9. 2010
    ..Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons...
  90. pmc Design, function and structure of a monomeric ClC transporter
    Janice L Robertson
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 468:844-7. 2010
    ..The results demonstrate that the ClC subunit alone is the basic functional unit for transport and that cross-subunit interaction is not required for Cl(-)/H(+) exchange in ClC transporters...
  91. ncbi Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters
    Gerardo Gamba
    Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Physiol Rev 85:423-93. 2005
    ....
  92. ncbi Thermodynamic regulation of NKCC1-mediated Cl- cotransport underlies plasticity of GABA(A) signaling in neonatal neurons
    Audrey C Brumback
    Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 28:1301-12. 2008
    ..Activity-induced changes in Na+-K+-ATPase activity comprise a novel mechanism for persistent alterations in synaptic signaling mediated by GABA...
  93. pmc Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction
    Wan Namkung
    Department of Medicine and Physiology, University of California, San Francisco, California 94143 0521, USA
    FASEB J 25:4048-62. 2011
    ..Small-molecule, TMEM16A-targeted activators may be useful for drug therapy of cystic fibrosis, dry mouth, and gastrointestinal hypomotility disorders, and for pharmacological dissection of TMEM16A function...
  94. pmc Mechanism of and exquisite selectivity for O-O bond formation by the heme-dependent chlorite dismutase
    Amanda Q Lee
    Brown Laboratory, Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 105:15654-9. 2008
    ..The data collectively suggest an O-O bond-forming mechanism involving generation of a compound I intermediate via oxygen atom transfer from chlorite, and subsequent recombination of the resulting hypochlorite and compound I...
  95. pmc A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system
    Brett M Rollins
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Respir Cell Mol Biol 39:190-7. 2008
    ..A(2B)-R are required for ASL volume homeostasis in human airways, and therapies directed at inhibiting A(2B)-R may lead to a cystic fibrosis-like phenotype with depleted ASL volume and mucus stasis...
  96. ncbi Chloride accumulation in mammalian olfactory sensory neurons
    Hiroshi Kaneko
    Institute for Biological Information Processing IBI 1, Forschungszentrum Julich, 52425 Julich, Germany
    J Neurosci 24:7931-8. 2004
    ..Cl(-) accumulation provides OSNs with the driving force for the depolarizing Cl(-) current that is the basis of the low-noise receptor current in these neurons...
  97. pmc Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance
    Omar A Itani
    Department of Internal Medicine, The Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 108:10260-5. 2011
    ..These results indicate that Na(+) conductance was not increased in these cultured CF tracheal/bronchial epithelia and point to loss of anion transport as key to airway epithelial dysfunction in CF...
  98. pmc The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients
    Eva K Roth
    Division of Pediatric Pulmonology and Allergy and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 6:e24445. 2011
    ..However, the effects of 1-EBIO on wild-type and mutant CFTR function in native human colonic tissues remain unknown...
  99. pmc Structural features promoting dioxygen production by Dechloromonas aromatica chlorite dismutase
    Brandon R Goblirsch
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    J Biol Inorg Chem 15:879-88. 2010
    ..Finally, a juxtaposition of hydrophobic residues between the distal pocket and the enzyme surface suggests O(2) may have a preferential direction for exiting the active site...
  100. ncbi Discovery of natural perchlorate in the Antarctic Dry Valleys and its global implications
    Samuel P Kounaves
    Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA
    Environ Sci Technol 44:2360-4. 2010
    ....
  101. pmc Imaging inhibitory synaptic potentials using voltage sensitive dyes
    Marco Canepari
    Division of Pharmacology and Neurobiology, Biozentrum University of Basel, Basel, Switzerland
    Biophys J 98:2032-40. 2010
    ..This study indicates that voltage imaging is a uniquely suited approach for the investigation of several fundamental aspects of inhibitory synaptic transmission that require spatial information...

Research Grants62

  1. System for Decontaminating Well Water for Drinking
    GIRISH SRINIVAS; Fiscal Year: 2010
    ..S. groundwater, both from natural and manmade sources, include significant quantities of magnesium and calcium chlorides (normal sources of hardness), heavy metals (e.g. lead), organic contaminants (e.g...
  2. BIOLOGICALLY ACTIVE CYCLIC PEPTIDES
    Dale L Boger; Fiscal Year: 2013
    ..derived from peptidoglycan remodeling of D-Ala-D-Ala, efforts to define and optimize the role of the aryl chlorides, and the full exploration of a new class of glycopeptide derivatives discovered in the last grant period that ..
  3. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2013
    ..as the catalyst/ligand complex, the electrophile (aryl, heteroaryl, alkenyl, alkynyl, alkyl), the nucleofuge (chlorides, sulfonates, phosphates), the solvent (e.g...
  4. Highly Active Palladium Catalysts for Organic Synthesis
    Qiao Sheng Hu; Fiscal Year: 2004
    ..We intend to develop extremely highly active palladium catalysts for coupling organic chlorides at room temperature and for carbon-carbon and carbon-heteroatom bonding formations that are difficult or ..
  5. SILOXANE COUPLINGS AND NATURAL PRODUCT SYNTHESIS
    Philip DeShong; Fiscal Year: 2001
    ..In addition, evaluation of new palladium catalysts for cross-couplings with aryl chlorides and the use of chiral ligands for an asymmetric version of the cross-coupling reaction will be undertaken...
  6. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  7. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  8. Divalent Metal Transporter: Role in Manganese Toxicity
    JEROME ROTH; Fiscal Year: 2004
    ....
  9. Regulation of Pendrin by Angiotensin II
    Susan Wall; Fiscal Year: 2007
    ..This proposal will explore how pendrin controls absorption of Cl- by the kidney and why activity of pendrin and ENaC are so dependent on each other. ..
  10. Designing HTA therapy for drug resistant malaria
    Christian Wolf; Fiscal Year: 2009
    ..Our long term goal is the identification of novel, inexpensive, efficacious therapy for treating drug resistant malaria. ..
  11. Daily genistein injections stimulate intestinal secretion: How?
    Layla Al Nakkash; Fiscal Year: 2007
    ..Furthermore, we aim to identify the suitability of genistein as a potential therapeutic for the most common lethal genetic disease in Caucasians, cystic fibrosis (CF). [unreadable] [unreadable] [unreadable]..
  12. FINE TUNING BINOLS AND BINAPS FOR ASYMMETRIC SYNTHESIS
    Bruce Lipshutz; Fiscal Year: 2001
    ..From ligands of this type come further options, such as opportunities for polymer mounting, and potentially of greatest attention, conversion to substituted cyclo BINAPs. ..
  13. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..scope of organic electro-philic components that will serve as partners in the cross-coupling reaction such as chlorides and triflates...
  14. MECHANISMS OF SULFATE TRANSPORT AND REGULATION
    Michael Jennings; Fiscal Year: 2007
    ..abstract_text> ..
  15. Mechanisms of CIC Chloride Transport Proteins
    Merritt Maduke; Fiscal Year: 2009
    ..Together, these studies will offer new insights into the functional relationships between channels and transporters. ..
  16. Metal-Mediated Routes to Biaryls
    Bruce Lipshutz; Fiscal Year: 2007
    ..A particular, albeit representative, application of a novel substituted cyclo-NOBIN will be studied for selected asymmetric aldol reactions. ..
  17. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  18. Aminoglycoside uptake and clearance in mammalian cells
    Takatoshi Karasawa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. MOLECULAR MECHANISMS OF PROXIMAL TUBULE ION TRANSPORT
    PETER ARONSON; Fiscal Year: 2006
    ..nephrolithiasis, osteoporosis) and NaC1 transport (eg. hypertension, congestive heart failure). ..
  20. K-Cl COTRANSPORTERS IN RAT NERVOUS SYSTEM
    John Payne; Fiscal Year: 2008
    ....
  21. Manganese-enhanced MRI Studies of Retinal Neovascularization
    BRUCE BERKOWITZ; Fiscal Year: 2008
    ..The novel methods in this application will also contribute to the advancement of functional MRI for the study of retinal diseases. [unreadable] [unreadable] [unreadable]..
  22. Clinical Proteomics Center in Lung Disease
    Frank Accurso; Fiscal Year: 2008
    ..Establish a national resource for investigators interested in developing protein biomarkers of lung disease. [unreadable] [unreadable]..
  23. FLT3-LIGAND, IMMUNOMODULATION AND THERAPY IN ASTHMA
    DEVENDRA AGRAWAL; Fiscal Year: 2008
    ..The long-term goal of this study is to better define the potential mechanisms of action of FL to prevent and reverse allergic airway inflammation and associated changes in pulmonary function. ..
  24. TRANSMURAL REGULATION Na/K PUMP ACTIVITY IN HEART
    Richard Mathias; Fiscal Year: 2009
    ..The aims of this proposal are to test these two hypotheses. We will use a combination of electrophysiological, Na- and Ca-imaging, contraction, and biochemical measurements to accomplish these aims. ..
  25. Role of airway submucosal glands in CF lung disease
    Alan S Verkman; Fiscal Year: 2010
    ..The data will provide a rigorous scientific rationale for use of small-molecules in CF therapy, and establish widely useful assays to prioritize small molecules for clinical development. ..
  26. Palladium- and Nickel-Catalyzed C-C Bond Formation
    GREGORY FU; Fiscal Year: 2009
    ..Mechanistic studies will play an important role in this project, since an improved understanding of metal-based reactivity should greatly facilitate catalyst development. ..
  27. Simulations of Calcium Selectivity and Binding
    Robert Eisenberg; Fiscal Year: 2009
    ..We will use these computations to design highly selective Ca channels of medical and technological interest. The simulations will suggest what needs to be improved in theory and design. ..
  28. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    ..Understanding oxalate handling in health and disease is essential for the development of potential pharmacological therapies. ..
  29. Proximal Tubule Transport Defect in Hyp Mice
    Michel Baum; Fiscal Year: 2007
    ..These studies will not only examine the pathogenesis of this disorder, but will directly examine if indomethacin potentially represents a novel therapy for this disease. ..
  30. Pseudopteroxazole and Related Antitubercular Agents
    Michael Harmata; Fiscal Year: 2007
    ..More generally, the methodology to be developed should have extremely broad impact, as it can be applied to the generation of stereogenic centers in a large number of compounds of biological and medicinal interest. ..
  31. Roles of polycystin and calcium in B-Raf signaling
    DARREN WALLACE; Fiscal Year: 2004
    ..2) Determine the mechanism by which the overexpression of the C-terminal fragment of PC1 in M1 cells, a condition thought to disrupt PC1/PC2 function, alters cAMP-dependent B-Raf signaling. ..
  32. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
  33. Bridge to the Doctorate at UMET: Building the Next Gene*
    Beatriz Zayas; Fiscal Year: 2005
    ..Thus, for the duration of the project a grand total of 540 students will benefit from these development activities and will learn more about graduate studies in biomedical sciences. ..
  34. 9th International Neurotoxicology Assoc (INA9) Meeting
    Michael Aschner; Fiscal Year: 2003
    ....
  35. Spike After-Potentials of Oxytocin Cells in Lactation
    Ryoichi Teruyama; Fiscal Year: 2005
    ..The specific aims of the application are to determine 1) what specific component of spike after-potentials (AHPs and DAP) is altered during lactation; 2) whether the responsive component is responsive to changes in the gonadal steroids. ..
  36. FACTORS RESPONSIBLE FOR THE CONTROL OF HUMAN LABOR
    ROGER YOUNG; Fiscal Year: 2003
    ....
  37. Determinants of early pancreatic injury in cystic fibro*
    Frank Accurso; Fiscal Year: 2004
    ..Our long-term objectives are to find new approaches to the early treatment of CF in order to delay pancreatic injury and the development of lung disease. ..
  38. NOX-mediated proton secretion by airways
    Horst Fischer; Fiscal Year: 2006
    ..This will help develop novel therapeutical targets for the treatment of airway acidity and inflammatory airway diseases. ..
  39. Radiopharmaceutical Dosimetry Symposium
    Michael Stabin; Fiscal Year: 2002
    ..abstract_text> ..
  40. Molecular Functions of the Adenovirus E1A Oncogene
    Maurice Green; Fiscal Year: 2006
    ..The functional consequences of interaction between E1A and specific cellular promoters will be established by kinetic studies of the gene specific mRNA and protein products. ..
  41. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
    ....
  42. MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITY
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
  43. NEW HIGHLY EFFICIENT ROUTES TO POLYKETIDES
    MICHAEL CALTER; Fiscal Year: 2002
    ..This property is very important for industrial syntheses, as each additional solvent and reactor increases the amount of waste and complexity of the process. ..
  44. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
  45. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2009
    ..The results of the proposed research will further improve the agents used for the treatment of acid-related diseases and also our knowledge of the ATPase and cellular events involved in regulation of its activity. ..
  46. Construction of Alpha-Siloxy-and Alpha-Amino-Amides
    ROBERT CUNICO; Fiscal Year: 2002
    ..Exploratory experiments directed towards inducing chiral stereoselectivity within these transformations will also be carried out. ..
  47. Enteric Elimination and Degradation of Oxalic Acid
    Marguerite Hatch; Fiscal Year: 2002
    ..The potential for the clinical application of a novel treatment strategy to reduce urinary oxalate excretion is broad-based and highly significant...
  48. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  49. Mucus Clearance in Acute COPD Exacerbations
    Richard Boucher; Fiscal Year: 2006
    ..The ultimate goals for the U.S. COPD patient population are to generate a mechanistic understanding of a major component of an AE and provide the mechanistic basis for novel therapies of AEs. ..
  50. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
    ..Hence this approach will provide additional insights into mechanisms of regulation of gastric secretion and enable illuminated interpretation of the pathophysiology of peptic ulcer disease. ..
  51. Molecular Physioloy of Brain Cation-Cl Cotransporters
    Eric Delpire; Fiscal Year: 2006
    ..abstract_text> ..
  52. MOLECULAR PHYSIOLOGY OF BAND 3 LIKE PROTEINS OF KIDNEY
    Seth Alper; Fiscal Year: 2007
    ..5. Define aspects of transcriptional and translational regulation of AE gene products in kidney of mutant and parental mouse strains and in cultured kidney cells. ..
  53. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  54. Realistic Phantom Series for OLINDA/EXM Version 2
    Michael Stabin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. BIOCHEMICAL MODEL REACTIONS
    Ronald Breslow; Fiscal Year: 2007
    ..In addition, both parts of the project will help us understand natural enzymes. [unreadable] [unreadable]..
  56. NO& Epithelial Repair in Cryptosporidiosis
    Jody Gookin; Fiscal Year: 2006
    ..abstract_text> ..
  57. Amination and Etherification of Aryl Halides and Olefins
    John Hartwig; Fiscal Year: 2008
    ..We will investigate the mechanisms of catalytic amination and etherification of aryl chlorides and tosylates...
  58. Septate junctional proteins: Proteomic identification and role in diuresis
    KLAUS BEYENBACH; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  59. 8th International Primary Hyperoxaluria Workshop
    Marguerite Hatch; Fiscal Year: 2007
    ..g. pediatric and adult nephrology, transplant surgery, metabolic medicine, molecular and cell biology, clinical and molecular genetics) to discuss their common interest in Primary Hyperoxaluria. [unreadable] [unreadable] [unreadable]..
  60. Mathematics of Ions in Protein Channels
    Robert Eisenberg; Fiscal Year: 2005
    ..The central issue in both traditions is to extend previous theories of equilibrium systems to allow prediction of the large currents measured in biological channels. ..
  61. Anticholinesterase Neurotoxicity is Mediated by Oxidative Injury
    Dejan Milatovic; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  62. Sickle Red Cell K+ Transporter Genetics in S. cerevisiae
    Seth Alper; Fiscal Year: 2002
    ..3) (Provisional Aim): Time permitting, to improve, validate, and standardize growth rescue of trk1delta/trk2delta S. cerevisiae by expression in nonpermissive conditions of cDNA encoding the mammalian IK1 K(ca) channel. ..