calcium carbonate

Summary

Summary: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.

Top Publications

  1. ncbi Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms
    James C Orr
    Laboratoire des Sciences du Climat et de l Environnement, UMR CEA CNRS, CEA Saclay, F 91191 Gif sur Yvette, France
    Nature 437:681-6. 2005
  2. ncbi Impact of anthropogenic CO2 on the CaCO3 system in the oceans
    Richard A Feely
    Pacific Marine Environmental Laboratory, National Oceanic and Atmospheric Administration, Seattle, WA 98115 6349, USA
    Science 305:362-6. 2004
  3. ncbi An acidic matrix protein, Pif, is a key macromolecule for nacre formation
    Michio Suzuki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Science 325:1388-90. 2009
  4. ncbi The oceanic sink for anthropogenic CO2
    Christopher L Sabine
    National Oceanic and Atmospheric Administration NOAA Pacific Marine Environmental Laboratory, 7600 Sand Point Way NE, Seattle, WA 98115, USA
    Science 305:367-71. 2004
  5. ncbi The progression of coronary artery calcification in predialysis patients on calcium carbonate or sevelamer
    D Russo
    Department of Nephrology, University Federico II, Naples, Italy
    Kidney Int 72:1255-61. 2007
  6. ncbi Proteins of calcified endoskeleton: II partial amino acid sequences of endoskeletal proteins and the characterization of proteinaceous organic matrix of spicules from the alcyonarian, Synularia polydactyla
    M Azizur Rahman
    Department of Marine and Environmental Sciences, University of the Ryukyus, Okinawa, Japan
    Proteomics 5:885-93. 2005
  7. pmc The effect of prepubertal calcium carbonate supplementation on the age of peak height velocity in Gambian adolescents
    Ann Prentice
    Medical Research Council Human Nutrition Research, Cambridge, United Kingdom
    Am J Clin Nutr 96:1042-50. 2012
  8. ncbi Mollusk shell formation: a source of new concepts for understanding biomineralization processes
    Lia Addadi
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Chemistry 12:980-7. 2006
  9. ncbi A new matrix protein family related to the nacreous layer formation of Pinctada fucata
    T Samata
    Laboratory of Cell Biology, Faculty of Environmental Health, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Japan
    FEBS Lett 462:225-9. 1999
  10. ncbi Amorphous Ca-phosphate precursors for Ca-carbonate biominerals mediated by Chromohalobacter marismortui
    Maria Angustias Rivadeneyra
    Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain
    ISME J 4:922-32. 2010

Detail Information

Publications370 found, 100 shown here

  1. ncbi Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms
    James C Orr
    Laboratoire des Sciences du Climat et de l Environnement, UMR CEA CNRS, CEA Saclay, F 91191 Gif sur Yvette, France
    Nature 437:681-6. 2005
    Today's surface ocean is saturated with respect to calcium carbonate, but increasing atmospheric carbon dioxide concentrations are reducing ocean pH and carbonate ion concentrations, and thus the level of calcium carbonate saturation...
  2. ncbi Impact of anthropogenic CO2 on the CaCO3 system in the oceans
    Richard A Feely
    Pacific Marine Environmental Laboratory, National Oceanic and Atmospheric Administration, Seattle, WA 98115 6349, USA
    Science 305:362-6. 2004
    ..This acidification process has changed the saturation state of the oceans with respect to calcium carbonate (CaCO3) particles...
  3. ncbi An acidic matrix protein, Pif, is a key macromolecule for nacre formation
    Michio Suzuki
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Science 325:1388-90. 2009
    The mollusk shell is a hard tissue consisting of calcium carbonate crystals and an organic matrix...
  4. ncbi The oceanic sink for anthropogenic CO2
    Christopher L Sabine
    National Oceanic and Atmospheric Administration NOAA Pacific Marine Environmental Laboratory, 7600 Sand Point Way NE, Seattle, WA 98115, USA
    Science 305:367-71. 2004
    ..The current fraction of total anthropogenic CO2 emissions stored in the ocean appears to be about one-third of the long-term potential...
  5. ncbi The progression of coronary artery calcification in predialysis patients on calcium carbonate or sevelamer
    D Russo
    Department of Nephrology, University Federico II, Naples, Italy
    Kidney Int 72:1255-61. 2007
    ..In this study, we evaluate the effect of calcium carbonate or sevelamer treatments on the progression of calcification in 90 predialysis patients...
  6. ncbi Proteins of calcified endoskeleton: II partial amino acid sequences of endoskeletal proteins and the characterization of proteinaceous organic matrix of spicules from the alcyonarian, Synularia polydactyla
    M Azizur Rahman
    Department of Marine and Environmental Sciences, University of the Ryukyus, Okinawa, Japan
    Proteomics 5:885-93. 2005
    ..These findings suggest that the endoskeletal spicules of alcyonarian corals have protein-rich organic matrices, which might be related to the calcification process...
  7. pmc The effect of prepubertal calcium carbonate supplementation on the age of peak height velocity in Gambian adolescents
    Ann Prentice
    Medical Research Council Human Nutrition Research, Cambridge, United Kingdom
    Am J Clin Nutr 96:1042-50. 2012
    ..Such an effect might be particularly marked in populations in whom low calcium intake, stunting, and delayed puberty are common...
  8. ncbi Mollusk shell formation: a source of new concepts for understanding biomineralization processes
    Lia Addadi
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Chemistry 12:980-7. 2006
    ..All this takes place in a highly structured chitinous framework. Here we present ideas on how these disparate components work together to produce the highly structured pearly nacreous layer of the mollusk shell...
  9. ncbi A new matrix protein family related to the nacreous layer formation of Pinctada fucata
    T Samata
    Laboratory of Cell Biology, Faculty of Environmental Health, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Japan
    FEBS Lett 462:225-9. 1999
    ..The aragonite crystals showed platy morphology different from those formed inorganically, and long intervals of incubation resulted in crystalline layers highly similar to the nacreous layer...
  10. ncbi Amorphous Ca-phosphate precursors for Ca-carbonate biominerals mediated by Chromohalobacter marismortui
    Maria Angustias Rivadeneyra
    Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain
    ISME J 4:922-32. 2010
    ....
  11. ncbi Long-term comparison of a calcium-free phosphate binder and calcium carbonate--phosphorus metabolism and cardiovascular calcification
    J Braun
    KfH Dialysezentrum Nürnberg, Germany
    Clin Nephrol 62:104-15. 2004
    b>Calcium carbonate used as a phosphate binder may contribute to cardiovascular calcification. Long-term comparisons of sevelamer, a non-calcium polymeric phosphate binder, and calcium carbonate (CC) are lacking.
  12. ncbi Early stages of crystallization of calcium carbonate revealed in picoliter droplets
    Christopher J Stephens
    School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Am Chem Soc 133:5210-3. 2011
    ..in the droplets than in the bulk, allowing the mechanism of crystallization, which progresses via amorphous calcium carbonate, to be easily observed...
  13. ncbi Stabilization of amorphous calcium carbonate by phosphate rich organic matrix proteins and by single phosphoamino acids
    Shmuel Bentov
    Department of Biotechnology Engineering, Ben Gurion University of the Negev, 84105, Israel
    J Struct Biol 171:207-15. 2010
    Stable amorphous calcium carbonate (ACC) is a unique material produced naturally exclusively as a biomineral. It was demonstrated that proteins extracted from biogenic stable ACC induce and stabilize synthetic ACC in vitro...
  14. ncbi Scleractinian coral species survive and recover from decalcification
    Maoz Fine
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, 52900, Israel
    Science 315:1811. 2007
    ..This refugia, however, does not undermine the threats to reef ecosystems in a high carbon dioxide world...
  15. pmc Synthesis of three-dimensional calcium carbonate nanofibrous structure from eggshell using femtosecond laser ablation
    Amirhossein Tavangar
    Department of Mechanical and Industrial Engineering, Ryerson University, Toronto, ON M5B 2K3, Canada
    J Nanobiotechnology 9:1. 2011
    ..Although there have been several studies on generating nanoparticles from eggshells, no research has been reported on synthesizing 3D nanofibrous structures...
  16. ncbi The initial stages of template-controlled CaCO3 formation revealed by cryo-TEM
    Emilie M Pouget
    Laboratory of Materials and Interface Chemistry, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, Netherlands
    Science 323:1455-8. 2009
    Biogenic calcium carbonate forms the inorganic component of seashells, otoliths, and many marine skeletons, and its formation is directed by an ordered template of macromolecules...
  17. ncbi Direct fabrication of large micropatterned single crystals
    Joanna Aizenberg
    Bell Laboratories Lucent Technologies, Murray Hill, NJ 07974, USA
    Science 299:1205-8. 2003
    ..Micropatterned templates organically modified to induce the formation of metastable amorphous calcium carbonate were imprinted with calcite nucleation sites...
  18. ncbi Spiers Memorial Lecture. Lessons from biomineralization: comparing the growth strategies of mollusc shell prismatic and nacreous layers in Atrina rigida
    Fabio Nudelman
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Faraday Discuss 136:9-25; discussion 107-23. 2007
    ..organized into a crystal nucleation site, where nucleation of aragonite, supposedly from colloidal amorphous calcium carbonate particles, is induced...
  19. ncbi A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophospha
    Nathan Hughes
    GlaxoSmithKline Consumer Healthcare, Weybridge, Surrey, UK
    J Clin Dent 21:49-55. 2010
    ..of an 8% strontium acetate, 1040 ppm sodium fluoride dentifrice to a marketed control 8% arginine, calcium carbonate, 1450 ppm sodium monofluorophosphate dentifrice after twice-daily brushing for two, four, and eight weeks.
  20. pmc Poorly cemented coral reefs of the eastern tropical Pacific: possible insights into reef development in a high-CO2 world
    Derek P Manzello
    Cooperative Institute of Marine and Atmospheric Studies, Rosenstiel School, Marine Biology and Fisheries, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, USA
    Proc Natl Acad Sci U S A 105:10450-5. 2008
    ..ETP reefs represent a real-world example of coral reef growth in low-Omega waters that provide insights into how the biological-geological interface of coral reef ecosystems will change in a high-CO(2) world...
  21. doi Oceans. Carbon emissions and acidification
    Richard E Zeebe
    Department of Oceanography, University of Hawaii, Honolulu, HI 96822, USA
    Science 321:51-2. 2008
  22. pmc The skeletal organic matrix from Mediterranean coral Balanophyllia europaea influences calcium carbonate precipitation
    Stefano Goffredo
    Marine Science Group, Alma Mater Studiorum Universita di Bologna, Bologna, Italy
    PLoS ONE 6:e22338. 2011
    Scleractinian coral skeletons are made mainly of calcium carbonate in the form of aragonite...
  23. ncbi Prismin: a new matrix protein family in the Japanese pearl oyster (Pinctada fucata) involved in prismatic layer formation
    Ryousuke Takagi
    Department of Genetic Engineering, Faculty of Biology Oriented Science and Technology, Kinki University, 930 Nishimitani, Kinokawa, Wakayama 649 6493, Japan
    Zoolog Sci 27:416-26. 2010
    ..Therefore, we conclude that prismin is a novel prismatic layer-specific calcite growth factor...
  24. pmc Shellfish face uncertain future in high CO2 world: influence of acidification on oyster larvae calcification and growth in estuaries
    A Whitman Miller
    Smithsonian Environmental Research Center, Edgewater, Maryland, United States of America
    PLoS ONE 4:e5661. 2009
    ....
  25. ncbi Mollusc larval shell formation: amorphous calcium carbonate is a precursor phase for aragonite
    Ingrid Maria Weiss
    Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Exp Zool 293:478-91. 2002
    ..Both species contain similar shell ultrastructures. We show that larval shells contain amorphous calcium carbonate (ACC), in addition to aragonite. The aragonite is much less crystalline than non-biogenic aragonite...
  26. ncbi A breakthrough therapy for dentin hypersensitivity: how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth
    Irene Petrou
    Colgate Palmolive Technology Center, Piscataway, NJ, USA
    J Clin Dent 20:23-31. 2009
    ..into the mechanism of action of a new technology for dentin hypersensitivity relief based upon arginine and calcium carbonate and, in particular, to address important questions regarding the nature and extent of dentin tubule occlusion...
  27. ncbi Stable prenucleation calcium carbonate clusters
    Denis Gebauer
    Max Planck Institute of Colloids and Interfaces, Research Campus Golm, Am Muhlenberg 1, D 14424 Potsdam, Germany
    Science 322:1819-22. 2008
    b>Calcium carbonate forms scales, geological deposits, biominerals, and ocean sediments. Huge amounts of carbon dioxide are retained as carbonate ions, and calcium ions represent a major contribution to water hardness...
  28. ncbi Calcitic microlenses as part of the photoreceptor system in brittlestars
    J Aizenberg
    Bell Laboratories Lucent Technologies, Murray Hill, New Jersey 07974, USA
    Nature 412:819-22. 2001
    ..These structures represent an example of a multifunctional biomaterial that fulfills both mechanical and optical functions...
  29. ncbi Elevated CO2 enhances otolith growth in young fish
    David M Checkley
    Scripps Institution of Oceanography, University of California, San Diego, CA 92093, USA
    Science 324:1683. 2009
    ..We hypothesize that CO2 moves freely through the epithelium around the otoliths in young fish, accelerating otolith growth while the local pH is controlled. This is the converse of the effect commonly reported for structural biominerals...
  30. ncbi Hemocyte-mediated shell mineralization in the eastern oyster
    Andrew S Mount
    Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA
    Science 304:297-300. 2004
    ..On the basis of scanning electron microscopy (SEM) and x-ray microanalysis, these granulocytes contain calcium carbonate crystals, and they increase in abundance relative to other hemocytes following experimentally induced shell ..
  31. ncbi Contribution of fish to the marine inorganic carbon cycle
    R W Wilson
    School of Biosciences, University of Exeter, Exeter EX4 4PS, UK
    Science 323:359-62. 2009
    Oceanic production of calcium carbonate is conventionally attributed to marine plankton (coccolithophores and foraminifera)...
  32. ncbi Evolution of nacre: biochemistry and proteomics of the shell organic matrix of the cephalopod Nautilus macromphalus
    Benjamin Marie
    UMR CNRS 5561 Biogeosciences, Universite de Bourgogne, 6 Bd Gabriel, 21000 Dijon, France
    Chembiochem 10:1495-506. 2009
    ..Strikingly, most of the obtained partial sequences are entirely new. A few only partly match with bivalvian nacre proteins.Our findings have implications for knowledge of the long-term evolution of molluskan nacre matrices...
  33. ncbi Intestinal bicarbonate secretion in marine teleost fish-source of bicarbonate, pH sensitivity, and consequences for whole animal acid-base and calcium homeostasis
    Rod W Wilson
    Department of Biological Sciences, Hatherly Laboratories, University of Exeter, Exeter EX4 4PS, UK
    Biochim Biophys Acta 1618:163-74. 2003
    ..Thus, both luminal Ca(2+) and H(+) can regulate HCO(3)(-) secretion but the precise mechanisms and their potential interaction are currently unresolved...
  34. ncbi Efficacy of a dentifrice containing 5% potassium nitrate and 1500 PPM sodium monofluorophosphate in a precipitated calcium carbonate base on dentinal hypersensitivity
    T Schiff
    University of the Pacific, San Francisco, CA, USA
    J Clin Dent 9:22-5. 1998
    ..0% potassium nitrate, 1500 ppm sodium monofluorophosphate in a precipitated calcium carbonate (PCC) base over an eight-week period was compared to a placebo dentifrice without potassium nitrate...
  35. pmc GFP facilitates native purification of recombinant perlucin derivatives and delays the precipitation of calcium carbonate
    Eva Weber
    INM Leibniz Institute for New Materials gGmbH, Saarbruecken, Germany
    PLoS ONE 7:e46653. 2012
    ..Second, GFP inhibited calcium carbonate precipitation in a concentration dependent manner...
  36. ncbi Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy
    Raffaella Docimo
    University of Rome at Tor Vergata, Department of Odonto Stomatology Cattedra Di Pedodonzia, Rome, Italy
    J Clin Dent 20:17-22. 2009
    ..0% arginine, calcium carbonate, and 1450 ppm fluoride as sodium monofluorophosphate (MFP) was compared to that of a benchmark commercial ..
  37. ncbi Ultrastructure, chemistry and mineralogy of the growing shell of the European abalone Haliotis tuberculata
    Stéphanie Auzoux-Bordenave
    UMR BOREA Biologie des Organismes et Ecosystèmes Aquatiques, MNHN CNRS 7208 IRD 207 UPMC, Museum national d histoire naturelle, Station de Biologie Marine, 29900 Concarneau, France
    J Struct Biol 171:277-90. 2010
    ..The results demonstrated that early protoconch was mostly composed of amorphous calcium carbonate, while veliger stages showed a gradually crystallization under the form of aragonite...
  38. ncbi Cellular compatibility of a gamma-irradiated modified siloxane-poly(lactic acid)-calcium carbonate hybrid membrane for guided bone regeneration
    Naoshi Takeuchi
    Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Dent Mater J 30:730-8. 2011
    ..These results suggest that the gamma-irradiated Si-PVH/PLA membrane is biocompatible with both fibroblasts and osteoblasts, and may have an application for GBR...
  39. ncbi Carbonic anhydrase in calcified endoskeleton: novel activity in biocalcification in alcyonarian
    M Azizur Rahman
    Department of Marine and Environmental Sciences, University of the Ryukyus, Okinawa, Japan
    Mar Biotechnol (NY) 10:31-8. 2008
    ..Our observations strongly suggest that the matrix protein in alcyonarian coral is not only a structural protein but also a catalyst...
  40. ncbi Caspartin and calprismin, two proteins of the shell calcitic prisms of the Mediterranean fan mussel Pinna nobilis
    Frederic Marin
    UMR CNRS 5561 Biogeosciences, Universite de Bourgogne, 6 Boulevard Gabriel, Dijon F 21000, France
    J Biol Chem 280:33895-908. 2005
    ..In vitro tests show that it inhibits the precipitation of calcium carbonate. Furthermore, it strongly interferes with the growth of calcite crystals...
  41. pmc Phase transitions in biogenic amorphous calcium carbonate
    Yutao U T Gong
    Department of Physics, University of Wisconsin Madison, 1150 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 109:6088-93. 2012
    ..purpuratus sea urchins, and observe a sequence of three mineral phases: hydrated amorphous calcium carbonate (ACC · H(2)O) → dehydrated amorphous calcium carbonate (ACC) → calcite...
  42. ncbi Biologically formed amorphous calcium carbonate
    Steve Weiner
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Connect Tissue Res 44:214-8. 2003
    Many organisms from a wide variety of taxa produce amorphous calcium carbonate (ACC), despite the fact that it is inherently unstable and relatively soluble in its pure state...
  43. ncbi Insights into the composition, morphology, and formation of the calcareous shell of the serpulid Hydroides dianthus
    Adrienne E Tanur
    Department of Chemistry, University of Toronto, 80 St George St, Toronto, ON, Canada M5S 3H6
    J Struct Biol 169:145-60. 2010
    ..The SOM and organic tube lining were found to contain carboxylated and sulphated polysaccharides. In an artificial seawater solution, the SOM and the organic tube lining mediated CaCO(3) mineralization in vitro...
  44. ncbi Hollow chitosan-alginate multilayer microcapsules as drug delivery vehicle: doxorubicin loading and in vitro and in vivo studies
    Qinghe Zhao
    Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China
    Nanomedicine 3:63-74. 2007
    ..The results showed that the encapsulated DOX had better efficacy than that of the free drug in terms of tumor inhibition in a 4-week in vivo culture period...
  45. ncbi Developmental biology meets materials science: Morphogenesis of biomineralized structures
    Fred H Wilt
    Department of Molecular Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Dev Biol 280:15-25. 2005
    ..frustules in sponges and diatoms, respectively; (2) the structure of skeletal spicules composed of amorphous calcium carbonate in some tunicates; (3) the secretion of the prism and nacre of some molluscan shells; (4) the development of ..
  46. ncbi Effect of a test dentifrice containing nano-sized calcium carbonate on remineralization of enamel lesions in vitro
    Syozi Nakashima
    Oral Care Research Laboratories, Lion Corporation, Odawara, Japan
    J Oral Sci 51:69-77. 2009
    The efficacy of a test dentifrice containing nano-sized (several tens to hundreds of nm) calcium carbonate (hereafter NC) on enamel lesion remineralization was studied in an in vitro system that employed collagen-coated wells for cell ..
  47. pmc Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients
    Anibal Ferreira
    Nephrology Department, Hospital Curry Cabral, Lisboa, Portugal
    J Am Soc Nephrol 19:405-12. 2008
    ..study, 119 hemodialysis patients were enrolled to compare the effects of sevelamer hydrochloride and calcium carbonate on bone. Biopsy-proven adynamic bone disease was the most frequent bone abnormality at baseline (59%)...
  48. ncbi The biogeochemical role of Actinobacteria in Altamira Cave, Spain
    Soledad Cuezva
    Laboratorio de Petrologia Aplicada, Departamento de Ciencias de la Tierra y del Medio Ambiente, Universidad de Alicante, Alicante, Spain
    FEMS Microbiol Ecol 81:281-90. 2012
    ..A tentative model for the formation of these grey spots, supported by scanning electron microscopy and transmission electron microscopy data, is proposed...
  49. ncbi Bacterially induced mineralization of calcium carbonate: the role of exopolysaccharides and capsular polysaccharides
    Claudia Ercole
    Department of Basic and Applied Biology, University of L Aquila, 67010 L Aquila, Italy
    Microsc Microanal 13:42-50. 2007
    ..Proteins with molecular masses of 25-40 kDa and 70 kDa in the CPS fraction were highly expressed in the presence of calcium oxalate. This high level of synthesis could be related to the binding of calcium ions and carbonate deposition...
  50. pmc Calcium/vitamin D supplementation and coronary artery calcification in the Women's Health Initiative
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 17:683-91. 2010
    ..We compared CAC scores after trial completion between women randomized to calcium/vitamin D supplementation and women randomized to placebo...
  51. ncbi On the origin of fiber calcite crystals in moonmilk deposits
    Juan Carlos Cañaveras
    Unidad Asociada CSIC UA, Laboratorio de Petrologia Aplicada, Departamento de Ciencias de la Tierra, Universidad de Alicante, Alicante, Spain
    Naturwissenschaften 93:27-32. 2006
    ....
  52. ncbi Patterns of distribution of calcite crystals in soft corals sclerites
    Ernestina Tentori
    ERT Scotland Ltd, Research Park South, Heriot Watt University, Edinburgh EH14 4AP, UK
    J Morphol 272:614-28. 2011
    ..Our study indicates that soft corals are ideal material to study natural gradients of calcification conditions...
  53. ncbi Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian ad
    Farid Ayad
    Canadian Clinical Research Center, Mississauga, Ontario, Canada
    J Clin Dent 20:10-6. 2009
    ..0% arginine, calcium carbonate, and 1450 ppm fluoride as sodium monofluorophosphate (MFP) was compared to that of a benchmark commercial ..
  54. ncbi Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark commercial desensitizing toothpaste containing 2% potassium ion: an eight-week clinical study
    R Docimo
    University of Rome at Tor Vergata, Department of Odonto Stomatology, Rome, Italy
    J Clin Dent 20:137-43. 2009
    ..0% arginine, calcium carbonate, and 1450 ppm fluoride as sodium monofluorophosphate (MFP), compared to that of a benchmark commercially ..
  55. ncbi Ultrastructure and mineral distribution in the tergal cuticle of the terrestrial isopod Titanethes albus. Adaptations to a karst cave biotope
    Sabine Hild
    Central Facility for Electron Microscopy, University of Ulm, Ulm, Germany
    J Struct Biol 168:426-36. 2009
    ..This may possibly be of advantage in maintaining high cuticle flexibility and reducing metabolic expenditures...
  56. ncbi The inhibitory effect of an arginine bicarbonate/calcium carbonate CaviStat-containing dentifrice on the development of dental caries in Venezuelan school children
    Ana Maria Acevedo
    Institute of Dental Research, Faculty of Dentistry, Central University of Venezuela, Caracas, Venezuela
    J Clin Dent 16:63-70. 2005
    This study assessed the effect of an arginine bicarbonate/calcium carbonate (CaviStat)-containing dentifrice on caries development, mainly in 11- to 12-year-old Venezuelan children over a two-year period.
  57. ncbi A novel extrapallial fluid protein controls the morphology of nacre lamellae in the pearl oyster, Pinctada fucata
    Zhuojun Ma
    Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China
    J Biol Chem 282:23253-63. 2007
    ..Here, a novel 38-kDa extrapallial fluid (EPF) protein, named amorphous calcium carbonate-binding protein (ACCBP), may partially answer this question...
  58. ncbi SensiStat. A new saliva-based composition for simple and effective treatment of dentinal sensitivity pain
    Israel Kleinberg
    Department of Oral Biology and Pathology, State University of New York at Stony Brook, USA
    Dent Today 21:42-7. 2002
  59. pmc Calcite formation in soft coral sclerites is determined by a single reactive extracellular protein
    M Azizur Rahman
    Department of Earth and Environmental Sciences, Palaeontology and Geobiology, Ludwig Maximilians Universitat, 80333 Munich, Germany
    J Biol Chem 286:31638-49. 2011
    b>Calcium carbonate exists in two main forms, calcite and aragonite, in the skeletons of marine organisms...
  60. ncbi Effect of calcium carbonate on clinical compliance of apatitic calcium phosphate bone cement
    I Khairoun
    Department of Materials Science and Metallurgy, Universitat Politecnica de Catalunya, Barcelona, Spain
    J Biomed Mater Res 38:356-60. 1997
    ..This area covered only pastes that could be applied as doughs. However, Biocement D showed a much larger area of full compliance and it covered both doughlike and injectable pastes...
  61. pmc Aragonite crystallization in primary cell cultures of multicellular isolates from a hard coral, Pocillopora damicornis
    I J Domart-Coulon
    Department of Biology and Division of Comparative Medicine, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 98:11885-90. 2001
    The foundation of marine coral reef ecosystems is calcium carbonate accumulated primarily by the action of hard corals (Coelenterata: Anthozoa: Scleractinia)...
  62. ncbi Effects of a dietary chitosan and calcium supplement on Ca and P metabolism in cats
    Elisabeth Wagner
    Institut für Ernährung, Veterinärmedizinische Universität Wien
    Berl Munch Tierarztl Wochenschr 117:310-5. 2004
    The aim of the present study in cats was to investigate the potential effects of a calcium carbonate and chitosan supplement on blood parameters in aged cats with moderate chronic renal failure and on the mineral balance in adult healthy ..
  63. ncbi Fabrication of hierarchical CaCO3 mesoporous spheres: particle-mediated self-organization induced by biphase interfaces and SAMs
    Xiaohong Liang
    College of Chemistry and Chemical Engineering, Graduate University of the Chinese Academy of Sciences, Beijing, 100049 China
    Langmuir 26:5882-8. 2010
    Highly ordered hierarchical calcium carbonate is an important phase involved in calcification by a wide variety of invertebrate organisms, and its formation is of technological interest in the development of functional materials...
  64. ncbi A Cretaceous scleractinian coral with a calcitic skeleton
    Jaroslaw Stolarski
    Institute of Paleobiology, Polish Academy of Sciences, Twarda 51 55, PL 00 818 Warsaw, Poland
    Science 318:92-4. 2007
    ..This result implies that corals, like other groups of marine, calcium carbonate-producing organisms, can form skeletons of different carbonate polymorphs.
  65. ncbi Bone formation with various bone graft substitutes in critical-sized rat calvarial defect
    Jin Woo Park
    Department of Periodontology, School of Dentistry, Kyungpook National University, Daegu, South Korea
    Clin Oral Implants Res 20:372-8. 2009
    ..We compared N-HA alone or in combination with calcium sulfate (CS), with a commercial bone substitute, anorganic bovine bone (Bio-Oss, BO)...
  66. ncbi Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae
    Emi Murayama
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, 113 8657 Tokyo, Japan
    Mech Dev 122:791-803. 2005
    ..They consist mainly of calcium carbonate and a small amount of organic matrix...
  67. ncbi Acute effects of calcium carbonate, calcium citrate and potassium citrate on markers of calcium and bone metabolism in young women
    Heini J Karp
    Calcium Research Unit, Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland
    Br J Nutr 102:1341-7. 2009
    ..We compared the effects of calcium carbonate, calcium citrate and potassium citrate on markers of Ca and bone metabolism in young women...
  68. ncbi Sponge paleogenomics reveals an ancient role for carbonic anhydrase in skeletogenesis
    Daniel J Jackson
    Geoscience Centre Göttingen, Department of Geobiology, Goldschmidtstrasse 3, D 37077 Gottingen, Germany
    Science 316:1893-5. 2007
    ....
  69. ncbi A novel matrix protein participating in the nacre framework formation of pearl oyster, Pinctada fucata
    Yong Zhang
    Department of Biological Sciences and Biotechnology, Tsinghua University, Haidian, 100084, Beijing, PR China
    Comp Biochem Physiol B Biochem Mol Biol 135:565-73. 2003
    ..Taken together, we have identified a novel matrix protein of the pearl oyster, which may play an important role in determining the texture of nacre...
  70. ncbi Sea urchin spine calcite forms via a transient amorphous calcium carbonate phase
    Yael Politi
    Department of Structural Biology, 76100 Rehovot, Israel
    Science 306:1161-4. 2004
    ..microscopy, we show that sea urchin spine regeneration proceeds via the initial deposition of amorphous calcium carbonate. Because most echinoderms produce the same type of skeletal material, they probably all use this same ..
  71. ncbi A novel nacre protein N19 in the pearl oyster Pinctada fucata
    Masato Yano
    Wakayama Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence, Japan Science and Technology Agency, Japan
    Biochem Biophys Res Commun 362:158-63. 2007
    ..In CaCO(3) precipitation assay, the recombinant N19 protein inhibited the crystallization of CaCO(3). These results indicate that N19 is localized in the nacre and plays a negative regulatory role in calcification in the pearl oyster...
  72. ncbi Rigid biological systems as models for synthetic composites
    George Mayer
    Department of Materials Science and Engineering, University of Washington, Roberts Hall 335, Box 352120, Seattle, WA 98195 2120, USA
    Science 310:1144-7. 2005
    ..Some of the important advantages and limitations of copying from nature are also described here...
  73. ncbi The nacre protein perlucin nucleates growth of calcium carbonate crystals
    S Blank
    Institut fur Biophysik, FB01 der Universität Bremen, Postfach 330440, 28334 Bremen, Germany
    J Microsc 212:280-91. 2003
    ..marine snail Haliotis laevigata on the microscopic scale and the interaction of purified nacre proteins with calcium carbonate crystals on the nanoscopic scale...
  74. ncbi Mucins and molluscan calcification. Molecular characterization of mucoperlin, a novel mucin-like protein from the nacreous shell layer of the fan mussel Pinna nobilis (Bivalvia, pteriomorphia)
    F Marin
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Biol Chem 275:20667-75. 2000
    ....
  75. pmc Transformation and crystallization energetics of synthetic and biogenic amorphous calcium carbonate
    A V Radha
    Peter A Rock Thermochemistry Laboratory and Nanomaterials in the Environment, Agriculture, and Technology Organized Research Unit NEAT ORU, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 107:16438-43. 2010
    Amorphous calcium carbonate (ACC) is a metastable phase often observed during low temperature inorganic synthesis and biomineralization...
  76. pmc Southern Ocean acidification: a tipping point at 450-ppm atmospheric CO2
    Ben I McNeil
    Climate Change Research Centre, Faculty of Science, University of New South Wales, Sydney NSW 2052, Australia
    Proc Natl Acad Sci U S A 105:18860-4. 2008
    ..calcifying plankton species by lowering the concentration of carbonate ion (CO(3)(2-)) to levels where calcium carbonate (both aragonite and calcite) shells begin to dissolve...
  77. ncbi In situ observation of nanograin rotation and deformation in nacre
    Xiaodong Li
    Department of Mechanical Engineering, University of South Carolina, 300 Main Street, Columbia, South Carolina 29208, USA
    Nano Lett 6:2301-4. 2006
    ..The biopolymer spacing between the nanograins facilitates the grain rotation process. The aragonite nanograins in nacre are not brittle but deformable...
  78. pmc A gastrolith protein serving a dual role in the formation of an amorphous mineral containing extracellular matrix
    Assaf Shechter
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Proc Natl Acad Sci U S A 105:7129-34. 2008
    ..crayfish, Cherax quadricarinatus, is fully characterized and its function in the mineralization of amorphous calcium carbonate (ACC) of the extracellular matrix is demonstrated...
  79. pmc Extracellular matrix production and calcium carbonate precipitation by coral cells in vitro
    Yael Helman
    Environmental Biophysics and Molecular Ecology Program and Inorganic Analytical Laboratory, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, 71 Dudley Road, New Brunswick, NJ 08901, USA
    Proc Natl Acad Sci U S A 105:54-8. 2008
    ..cell-substrate adhesion; (ii) a skeletal organic matrix (SOM), which facilitates controlled deposition of a calcium carbonate skeleton; and (iii) the calcium carbonate skeleton itself, which provides the structural support for the 3D ..
  80. pmc Cloning and characterization of Prisilkin-39, a novel matrix protein serving a dual role in the prismatic layer formation from the oyster Pinctada fucata
    Yawei Kong
    Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, and Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing 100084, China
    J Biol Chem 284:10841-54. 2009
    ..These observations may extend our view on the rare group of basic matrices and their functions during elaboration of the molluscan shell...
  81. ncbi Factors involved in the formation of amorphous and crystalline calcium carbonate: a study of an ascidian skeleton
    Joanna Aizenberg
    Bell Laboratories Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974, USA
    J Am Chem Soc 124:32-9. 2002
    ..Here we describe a composite skeletal tissue from an ascidian in which amorphous and crystalline calcium carbonate coexist in well-defined domains separated by an organic sheath...
  82. ncbi Analysis of proteinaceous components of the organic matrix of endoskeletal sclerites from the alcyonarian Lobophytum crassum
    M Azizur Rahman
    Department of Marine and Environmental Sciences, Faculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara cho, Okinawa 903 0213, Japan
    Calcif Tissue Int 78:178-85. 2006
    ..we show that the matrix proteins extracted from the calcitic sclerites induce the formation of amorphous calcium carbonate prior to its transformation into the calcitic crystalline form...
  83. ncbi Nucleation and growth of aragonite crystals at the growth front of nacres in pearl oyster, Pinctada fucata
    Kazuko Saruwatari
    Department of Earth and Planetary Science, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biomaterials 30:3028-34. 2009
    ..These results indicate that the crystal growth of aragonite at the growth front results from not only biotic process but also inorganic ones such as geometrical selection and mineral bridges...
  84. ncbi The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats
    Mario Cozzolino
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Am Soc Nephrol 13:2299-308. 2002
    ..Using an experimental model of CRF, these studies compare sevelamer and calcium carbonate (CaCO(3)) in the control of serum P, secondary hyperparathyroidism (SH), and ectopic calcifications...
  85. ncbi Efficacy, tolerability, and safety of lanthanum carbonate in hyperphosphatemia: a 6-month, randomized, comparative trial versus calcium carbonate
    A J Hutchison
    Manchester Institute of Nephrology and Transplantation, The Royal Infirmary, Manchester, UK
    Nephron Clin Pract 100:c8-19. 2005
    ..Existing oral phosphate binders have not permitted control of serum phosphate within currently accepted guidelines. This study compares lanthanum carbonate with calcium carbonate for control of serum phosphate in hemodialysis patients.
  86. pmc In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure
    Wenfu Lu
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Hear Res 268:172-83. 2010
    ....
  87. ncbi A novel matrix protein p10 from the nacre of pearl oyster (Pinctada fucata) and its effects on both CaCO3 crystal formation and mineralogenic cells
    Cen Zhang
    Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, People s Republic of China
    Mar Biotechnol (NY) 8:624-33. 2006
    ..In vitro crystallization experiments showed that p10 could accelerate the nucleation of calcium carbonate crystals and induce aragonite formation, suggesting that it might play a key role in nacre biomineralization...
  88. ncbi Multicenter prospective randomized, double-blind comparative study between lanthanum carbonate and calcium carbonate as phosphate binders in Japanese hemodialysis patients with hyperphosphatemia
    T Shigematsu
    Division of Nephrology and Blood Purification Medicine, Department of Medicine, Wakayama Medical University, School of Medicine, Wakayama City, Japan
    Clin Nephrol 70:404-10. 2008
    ..The efficacy of lanthanum carbonate as a phosphate binder for the treatment of hyperphosphatemia has been reported, but not from a double-blind, comparator-controlled comparative study...
  89. ncbi The clinical effect of a single direct topical application of a dentifrice containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride on dentin hypersensitivity: the use of a cotton swab applicator versus the use of a fingertip
    T Schiff
    Scottsdale Center for Dentistry, San Francisco, CA, USA
    J Clin Dent 20:131-6. 2009
    ..0% arginine, calcium carbonate, and 1450 ppm fluoride, as sodium monofluorophosphate (MFP), in providing instant relief of dentin ..
  90. ncbi Structural biology. Choosing the crystallization path less traveled
    S Weiner
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 309:1027-8. 2005
  91. ncbi A new paradigm for biomineral formation: mineralization via an amorphous liquid-phase precursor
    Matthew J Olszta
    Department of Materials Science and Engineering, University of Florida, Gainesville, Florida 32611, USA
    Connect Tissue Res 44:326-34. 2003
    ....
  92. pmc Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish
    Jessica A Petko
    Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA
    Dev Neurobiol 68:209-22. 2008
    ..Otoconia and otoliths are composed of calcium carbonate crystals condensed on a core protein lattice...
  93. pmc Transformation mechanism of amorphous calcium carbonate into calcite in the sea urchin larval spicule
    Yael Politi
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 105:17362-6. 2008
    Sea urchin larval spicules transform amorphous calcium carbonate (ACC) into calcite single crystals...
  94. ncbi Heterogeneous uptake and reactivity of formic acid on calcium carbonate particles: a Knudsen cell reactor, FTIR and SEM study
    Hashim A Al-Hosney
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52246, USA
    Phys Chem Chem Phys 7:3587-95. 2005
    ..uptake and reactivity of formic acid (HCOOH), a common gas-phase organic acid found in the environment, on calcium carbonate (CaCO(3)) particles have been investigated using a Knudsen cell reactor, Fourier transform infrared (FTIR) ..
  95. pmc In situ molecular NMR picture of bioavailable calcium stabilized as amorphous CaCO₃ biomineral in crayfish gastroliths
    Anat Akiva-Tal
    Schulich Faculty of Chemistry and Russell Berrie Nanotechnology Institute, Technion Israel Institute of Technology, Haifa 32000 Israel
    Proc Natl Acad Sci U S A 108:14763-8. 2011
    ..calcium is maintained by some crustaceans, in particular freshwater crayfish, by stabilizing amorphous calcium carbonate (ACC) within reservoir organs--gastroliths, readily providing the Ca(2+) needed to build a new exoskeleton...
  96. ncbi Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity
    Thomas Schiff
    Scottsdale Center for Dentistry, San Francisco, California, USA
    Am J Dent 22:8A-15A. 2009
    To determine the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate relative to that of a commercially-available pumice prophylaxis paste in reducing dentin hypersensitivity instantly after a single ..
  97. ncbi Mechanical properties of modern calcite- (Mergerlia truncata) and phosphate-shelled brachiopods (Discradisca stella and Lingula anatina) determined by nanoindentation
    Casjen Merkel
    Department für Geo und Umweltwissenschaften and GeoBioCenter, LMU Munich, Germany
    J Struct Biol 168:396-408. 2009
    ..The strongly mineralized laminae, which provide the strength to the shell, are also brittle, but keeping them as thin as possible, allows some bending flexibility. This flexibility is not required for the epibenthic life style...
  98. ncbi Rheological properties of calcium carbonate self-setting injectable paste
    C Combes
    Universite de Toulouse, CIRIMAT, UPS INPT CNRS, ENSIACET, 4, allée Emile Monso, BP 74233, 31432 Toulouse Cedex 4, France
    Acta Biomater 6:920-7. 2010
    ..5 kg, revealing the ease of injection of this CaCO(3) self-setting paste...
  99. ncbi Raman spectroscopic study of the mineral composition of cirratulid tubes (Annelida, Polychaeta)
    Paul D Taylor
    Department of Palaeontology, Natural History Museum, London SW7 5BD, United Kingdom
    J Struct Biol 171:402-5. 2010
    ..Similarly, the mineralogies of the earliest skeletons matched seawater chemistry in three other polychaete groups that independently evolved calcareous skeletons...
  100. ncbi Evidence for calcium carbonate at the Mars Phoenix landing site
    W V Boynton
    Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721, USA
    Science 325:61-4. 2009
    ..b>Calcium carbonate (approximately 3 to 5 weight percent) has been identified in the soils around the Phoenix landing site by ..
  101. ncbi Control of crystal polymorph in microfluidics using molluscan 28 kDa Ca²(+)-binding protein
    Bozhi Ji
    Department of Geographical and Earth Sciences, University of Glasgow, UK
    Integr Biol (Camb) 2:528-35. 2010
    ....

Research Grants62

  1. CALCIUM IN THE PREVENTION OF NEOPLASTIC POLYPS
    John Baron; Fiscal Year: 2003
    ..The trial studied whether supplementation with calcium carbonate (1200 mg calcium per day) prevented the recurrence of colorectal adenomas in 930 patients with a recent ..
  2. Utilization of calcite for the reduction of coal mine dust toxicity
    Xi Huang; Fiscal Year: 2010
    ..This innovative dust mitigation strategy to reduce dust toxicity does not require sophisticated engineering breakthrough and could prevent occupational lung diseases in underground coal workers. ..
  3. Regulation of Adipose Tissue Inflammation and Insulin Resistance by T Cell Subset
    ERICA LYN STONE; Fiscal Year: 2013
    ....
  4. Tat mediation of HIV-associated mood disorders via functional deficits in brain
    Jay P McLaughlin; Fiscal Year: 2013
    ....
  5. Dietary Marine Algae Extract and Colon Cancer Chemoprevention
    James Varani; Fiscal Year: 2010
    ..As controls, other mice will be fed the high fat diet supplemented with inorganic Ca2+ (calcium carbonate)...
  6. Advanced Training in Environmental Health Sciences
    Pamela J Lein; Fiscal Year: 2013
    ....
  7. Genetic Regulation of interferon Alpha in Human Lupus
    Timothy B Niewold; Fiscal Year: 2013
    ..Our findings could allow for more specific and personalized therapies targeting the IFN-a pathway in human SLE, and may suggest preventive strategies. ..
  8. Dissecting Biomineralization by Mining the Transcriptome of Three Closely Related
    BETSY ANNE READ; Fiscal Year: 2013
    ..third most prominent group of phytoplankton with over 300 extant species, each of which displays a unique calcium carbonate cell covering...
  9. Modeling Professional Attitudes and Teaching Humanistic Communication in VR
    FREDERICK WILLIAM KRON; Fiscal Year: 2013
    ..At the end of Phase II, MCW will have created a ground-breaking software program that can be used to teach medical students the ACGME competencies that all physicians should demonstrate when caring for a patient with terminal illness. ..
  10. Matrix Component Interactions in Bone, Dentin, and Invertebrate Mineral
    Arthur Veis; Fiscal Year: 2013
    ..abstract_text> ..
  11. Colorectal Chemoprevention with Calcium and Vitamin D
    JOHN ANTHONY BARON; Fiscal Year: 2013
    ..A total of 2259 subjects have been randomized to calcium carbonate (1200 mg calcium/day), vitamin D (1000 IU/day), both agents, or placebo...
  12. Characterization of Small Silencing RNAs in Emiliania Huxleyi
    Xiaoyu Zhang; Fiscal Year: 2013
    ..provided by applicant): Coccolithophorids are marine phytoplanktons that produce elegantly sculptured calcium carbonate cell coverings known as coccoliths. Emiliania huxleyi (E...
  13. Molecular Characterization of Key Proteins Directing Otoconial Mineralization
    RUEDIGER R THALMANN; Fiscal Year: 2013
    ..In the normal aging process and numerous diseases otoconia degenerate, resulting in loss of equilibrium, agility, falls, and bone fracture-the leading cause of accidental death in the elderly. ..
  14. Translational Neuroscientist and the Hope Center
    Alison M Goate; Fiscal Year: 2010
    ..It is anticipated that these pilot projects will develop into larger collaborative projects such new program projects. ..
  15. SHORT TERM TRAINING IN HEALTH PROFESSIONAL SCHOOLS
    ROBINNA G LORENZ; Fiscal Year: 2013
    ..In summary, the data indicate that this Short Term Training Program has been successful at achieving its goals. Thus, in the present application, we are requesting funding to continue this training program for another five years. ..
  16. EFFECTS OF BILE ACIDS ON CALCIUM AND IRON ABSORPTION
    Edward Moore; Fiscal Year: 1990
    ..Studies are also proposed to determine possible enhancement of ileal Ca++, Fe++ and Fe++ absorption by bile salt transport...
  17. Training in Drug Abuse Research: Behavior and Neurobiology
    Charles P France; Fiscal Year: 2013
    ..This program provides rigorous interdisciplinary training in behavioral and neurobiological research, thereby addressed a national demand for addiction scientists who can succeed in the current translational research environment. ..
  18. RECTAL MUCOSAL PROLIFERATION INDICES--EFFECTS OF CALCIUM
    John Baron; Fiscal Year: 1992
    ..They are randomized to receive either daily calcium carbonate supplementation (1200 mg calcium) or placebo, and undergo surveillance colonoscopy approximately one year ..
  19. IRON, CALCIUM AND OXIDATIVE STRESS IN LUNG INJURY
    Xi Huang; Fiscal Year: 2001
    ..By determining the role of calcite, it is possible to propose alternative methods for lung disease prevention. ..
  20. CLINICAL TRAILS IN PEDIATRIC RHEUMATOLOGY
    Daniel Lovell; Fiscal Year: 2004
    ..trial (RCT) to determine the efficacy of daily oral calcium supplementation (1000 mg/day of calcium carbonate) for two years to increase total body bone mineral density (TB BMD) by 10% (1...
  21. CONCENTRATED AEROSOL DELIVERY AND QUANTIZATION SYSTEM
    LID WONG; Fiscal Year: 1999
    ..This system can also act as a forerunner for the development of technologies for measuring cardiopulmonary function and aerosol deliveries to premature infants. ..
  22. Gene Regulatory Networks for Development
    William S Reznikoff; Fiscal Year: 2013
    ..Course faculty includes experts in genomics, molecular genetics, gene regulatory mechanisms, bioinformatics, computation and graphic design, and development. ..
  23. Training Program in Biomolecular Technology
    Bruce D Hammock; Fiscal Year: 2013
    ..The Program is designed to recruit and support trainees who show exceptional promise and to immerse them in an environment that will prepare them to be independent scientists who will advance the field of US health research. ..
  24. Behavioral consequences of 5-lipoxygenase deficiency
    Radmila Manev; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. Multidisciplinary training in cardiovascular biology
    Peter Francis Davies; Fiscal Year: 2013
    ..Participation is mandatory in the benchmark Interdisciplinary Seminar Series (>40 lectures/year) and biweekly Chalk Talks. Minority (3 of 11) and Women representation (6of 11) is strong. ..
  26. Mechanical Induced Resonant Mixing for Islet Separation
    FANGXIAO YANG; Fiscal Year: 2004
    ..A salient feature of the resonant mixing technology is its capacity as compact and flexible tissue digestion reactor for a broad range of cell separation and purification processes. ..
  27. CHARACTERIZATION/ISOLATION--BIOCALCIFICATION INHIBITORS
    SYBIL BURGESS; Fiscal Year: 1992
    ..Water soluble biomolecules which inhibit calcium carbonate precipitation in vitro, are present in the crab's nascent premolt cuticle...
  28. Aberrant Crypt Foci as a Biomarker for Chemoprevention
    Frank Sinicrope; Fiscal Year: 2009
    ..patients with prior advanced colonic adenomas or carcinomas evaluating aspirin alone and in combination with calcium carbonate or difluoromethylornithine over a 12 month period...
  29. INTERPLAY OF BIOLOGICAL AND PHYSICAL PROCESSES IN OTOCONIAL MORPHOGENESIS
    Ruediger Thalmann; Fiscal Year: 2009
    ..Information gained should ultimately provide means to slow down the deleterious effects of aging on otoconia, in a manner similar to our ability to prevent and/or ameliorate dental caries or osteoporosis. ..
  30. BIOCHEMISTRY OF EMBRYONIC SKELETON FORMATION
    William Lennarz; Fiscal Year: 1990
    ..In the sea urchin embryo the skeleton (spicule), composed mainly of crystalline calcium carbonate, is synthesized by primary mesenchyme cells...
  31. 4 iron-4sulfur Clusters in Aging and Alzheimer's Disease
    Valter Longo; Fiscal Year: 2004
    ..abstract_text> ..
  32. ALPHA-SENSE THERAPY OF DIABETIC GLOMERULOSCLEROSIS
    N STANLEY NAHMAN JR; Fiscal Year: 2000
    ..studies seek to improve glomerular gene delivery through the use of biodegradable microspheres (composed of calcium carbonate, CalCarb) and a novel, second generation adenovector (LoxAv) which, lacking all non-essential viral DNA, ..
  33. SYMPOSIUM ON THE BIOLOGY & THERAPY OF OVARIAN CANCER
    Robert Ozols; Fiscal Year: 1990
    ..The Proceedings of the meeting will be published after peer review within one year to allow rapid dissemination of this information to basic scientists and clinicians involved in the treatment of ovarian cancer...
  34. CAREER DEVELOPMENT IN WOMEN'S HEALTH RESEARCH AND GENDE*
    Ellen Freeman; Fiscal Year: 2006
    ..The BIRCWH program will track the career trajectories of Scholars and will continue to serve as a resource in terms of career counseling and research advice. [unreadable] [unreadable]..
  35. Cloning and Analysis of Head Tilt, A Vestibular Mutant
    DAVID BERGSTROM; Fiscal Year: 2003
    ..In preliminary studies, the pathology of this mutant has revealed a complete absence of otoconia, the calcium carbonate crystals that stimulate the vestibular maculae during linear acceleration and gravity...
  36. EPIDEMIOLOGIC METHODS FOR ESTIMATING AIRBORNE EXPOSURES
    David Kriebel; Fiscal Year: 1992
    ..Results are compared to those obtained by more conventional methods. Studies will focus on the bronchoconstrictive effects of: ozone, irritating dusts generated in the processing of borates and limestone, and of welding fume...
  37. 'Training in Endocrinology and Neurobiology of Aging'
    Caleb Finch; Fiscal Year: 2007
    ..Opportunities for human studies on aging, including ethnic differences in aging processes, are provided through the Alzheimer Disease Research Center and the Diabetes Research Center. ..
  38. CO2 REMOVAL IN CLOSED LOOP VENTILATION SYSTEMS
    J Montoya; Fiscal Year: 1992
    A system is proposed that continuously removes carbon dioxide from exhaled gas without the use of calcium carbonate crystals...
  39. Otopetrin 1: a novel regulator intracellular calcium
    Inna Hughes; Fiscal Year: 2006
    ..may be involved in the early steps of otoconial formation, in particular, the nucleation and growth of calcium carbonate crystals around an organic core...
  40. Signaling activities of amelogenin gene splice products.
    Arthur Veis; Fiscal Year: 2006
    ..In this revision, more experimental details have been provided. ..
  41. STRUCTURAL STUDIES OF MATRIX PROTEINS IN TEETH AND BONES
    STEPHEN WEINER; Fiscal Year: 2007
    ..abstract_text> ..
  42. BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESS
    Robert Heaney; Fiscal Year: 2001
    ....
  43. Bone-Sparing by Ca Salts With & Without Extra Phosphorus
    Robert Heaney; Fiscal Year: 2008
    ..The salt most commonly used for these purposes is calcium carbonate. But while the average P intake tends to be adequate or generous, nevertheless substantial proportions of ..
  44. STRUCTURE & ASSEMBLY OF COLLAGEN MOLECULES & FIBRILS
    Arthur Veis; Fiscal Year: 2004
    ..The final study (4) will examine N-telopeptide structures as related to molecular assembly into fibrils and the cross-link patterns that modulate packing. These studies will help in understanding dysfunction in humans. ..
  45. ANXIETY, DISINHIBITION, AND RISK FOR DRUG ABUSE
    Kimberly Yonkers; Fiscal Year: 2003
    ..phenotypic indices of vulnerability using combinations of clinical and psychophysiological measures. ..
  46. GENETICS OF RECURRENT EARLY-ONSET DEPRESSION (GENRED)
    GEORGE ZUBENKO; Fiscal Year: 2002
    ..A timetable is proposed for rapid sharing of all biological materials, blinded clinical data, genotypes and linkage analyses with the scientific community through the NIMH-sponsored Center for Genetic Studies. ..
  47. 24,25-DIHYDROXYVITAMIN D: MARKER OF SALT SENSITIVITY
    Connie Weaver; Fiscal Year: 2001
    ..Furthermore, they should provide an explanation for the paradox that blacks can build higher bone density, have a lower rate of bone turnover, and excrete less urinary calcium on the same sodium loads compared to whites. ..
  48. DETECTION AND TREATMENT OF POSTPARTUM DEPRESSION
    Kimberly Yonkers; Fiscal Year: 2003
    ..abstract_text> ..
  49. Molecular modulation of calcium oxalate crystallization
    James De Yoreo; Fiscal Year: 2005
    ..The knowledge derived from our studies will assist in the design of inhibitory molecules that are potentially useful in therapy of stone disease. ..
  50. In-vivo intravascular autoradiography with storage phosphor detector
    POLAD SHIKHALIEV; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  51. Effects of Perinatal Depression on PTD and LBW
    Kimberly Yonkers; Fiscal Year: 2008
    ..Further, if we determine antidepressants increase the risk of adverse perinatal outcomes, treatment with psychotherapy rather than antidepressants should be considered when recommending therapeutic options. [unreadable] [unreadable]..
  52. MORPHOLOGIC/NEUROCHEMICAL CORRELATES OF DEPRESSION IN AD
    GEORGE ZUBENKO; Fiscal Year: 2009
    ..abstract_text> ..
  53. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
    ..The number of prenatally MA exposed children continues to grow. Our goal is to develop models of early MA exposure that permit an understanding of the long-term consequences on brain development and cognition. ..
  54. Determination of RDA for Vitamin D in Caucasian and African American Women
    John Gallagher; Fiscal Year: 2009
    ..The results from this study will also help in designing future larger clinical trials of the effect of vitamin D on falls and fractures. ..
  55. Compact, low-maintenance MRI system for animal lung imaging
    DEAN KUETHE; Fiscal Year: 2007
    ..In Phase II, we will integrate the permanent magnet with compact electronics to create a prototype small animal imaging system. [unreadable] [unreadable] [unreadable]..
  56. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  57. ROLE OF PARATHYROID HORMONE IN RENAL OSTEODYSTROPHY
    Isidro B Salusky; Fiscal Year: 2009
    ..The results of the study should provide new information on the relationship between PTH and bone formation in CKD and they are likely to have important implications for the diagnosis and treatment of renal osteodystrophy. ..
  58. In Vivo BM Stem Cell Gene Transfer for MPS type I
    Dao Pan; Fiscal Year: 2006
    ..Taken together, these data would not only open a door to a novel approach for treatment of human diseases, but also provide a new tool to study adult stem cell plasticity and the nature of hematopoiesis. ..
  59. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..