alum compounds

Summary

Summary: Aluminum metal sulfate compounds used medically as astringents and for many industrial purposes. They are used in veterinary medicine for the treatment of ulcerative stomatitis, leukorrhea, conjunctivitis, pharyngitis, metritis, and minor wounds.

Top Publications

  1. ncbi Phosphorus removal from synthetic and municipal wastewater using spent alum sludge
    D A Georgantas
    Laboratory of Chemical Process Engineering, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, GR 15780 Zografos, Athens, Greece
    Water Sci Technol 52:525-32. 2005
  2. ncbi Removal of pharmaceuticals in drinking water treatment: effect of chemical coagulation
    N Vieno
    Abo Akademi University, Department of Organic Chemistry, Biskopsgatan 8, FIN 20500 Abo, Finland
    Environ Technol 27:183-92. 2006
  3. ncbi DNA released from dying host cells mediates aluminum adjuvant activity
    Thomas Marichal
    Laboratory of Cellular and Molecular Physiology, Groupe Interdisciplinaire de Genoproteomique Appliquee, University of Liege, Liege, Belgium
    Nat Med 17:996-1002. 2011
  4. ncbi Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
    Tracy L Flach
    Immunology Research Group, Department of Microbiology and Infectious Diseases, and Snyder Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Med 17:479-87. 2011
  5. pmc Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
    Amy S McKee
    Howard Hughes Medical Institute, Denver, CO 80206, USA
    J Immunol 183:4403-14. 2009
  6. ncbi Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    Stephanie C Eisenbarth
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 453:1122-6. 2008
  7. ncbi Promotion of B cell immune responses via an alum-induced myeloid cell population
    Michael B Jordan
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA
    Science 304:1808-10. 2004
  8. pmc Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, 3015 GD Rotterdam, Netherlands
    J Exp Med 205:869-82. 2008
  9. ncbi Aluminium compounds for use in vaccines
    Erik B Lindblad
    Adjuvant Department, Brenntag Biosector, DK 3600 Frederikssund, Denmark
    Immunol Cell Biol 82:497-505. 2004
  10. pmc Type II NKT cells facilitate Alum-sensing and humoral immunity
    Hemangi B Shah
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Leukoc Biol 92:883-93. 2012

Research Grants

Detail Information

Publications200 found, 100 shown here

  1. ncbi Phosphorus removal from synthetic and municipal wastewater using spent alum sludge
    D A Georgantas
    Laboratory of Chemical Process Engineering, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, GR 15780 Zografos, Athens, Greece
    Water Sci Technol 52:525-32. 2005
    ..Finally this spent alum sludge was tested on municipal wastewater and proved to be effective as apart from phosphorus it was shown to remove turbidity and COD...
  2. ncbi Removal of pharmaceuticals in drinking water treatment: effect of chemical coagulation
    N Vieno
    Abo Akademi University, Department of Organic Chemistry, Biskopsgatan 8, FIN 20500 Abo, Finland
    Environ Technol 27:183-92. 2006
    ....
  3. ncbi DNA released from dying host cells mediates aluminum adjuvant activity
    Thomas Marichal
    Laboratory of Cellular and Molecular Physiology, Groupe Interdisciplinaire de Genoproteomique Appliquee, University of Liege, Liege, Belgium
    Nat Med 17:996-1002. 2011
    ....
  4. ncbi Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
    Tracy L Flach
    Immunology Research Group, Department of Microbiology and Infectious Diseases, and Snyder Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Med 17:479-87. 2011
    ..This study therefore suggests an unexpected mechanism for how this crystalline structure interacts with the immune system and how the DC plasma membrane may behave as a general sensor for solid structures...
  5. pmc Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
    Amy S McKee
    Howard Hughes Medical Institute, Denver, CO 80206, USA
    J Immunol 183:4403-14. 2009
    ..These data suggest that activation of the inflammasome and the type 2 innate response orchestrated by macrophages and mast cells in vivo are not required for adjuvant effect of alum on endogenous T and B cell responses...
  6. ncbi Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    Stephanie C Eisenbarth
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 453:1122-6. 2008
    ..This is likely to affect how we design effective, but safe, adjuvants in the future...
  7. ncbi Promotion of B cell immune responses via an alum-induced myeloid cell population
    Michael B Jordan
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA
    Science 304:1808-10. 2004
    ..These studies reveal a key role for a previously unknown accessory myeloid cell population in the generation of humoral immune responses...
  8. pmc Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, 3015 GD Rotterdam, Netherlands
    J Exp Med 205:869-82. 2008
    ..These findings suggest that alum adjuvant is immunogenic by exploiting "nature's adjuvant," the inflammatory DC through induction of the endogenous danger signal uric acid...
  9. ncbi Aluminium compounds for use in vaccines
    Erik B Lindblad
    Adjuvant Department, Brenntag Biosector, DK 3600 Frederikssund, Denmark
    Immunol Cell Biol 82:497-505. 2004
    ....
  10. pmc Type II NKT cells facilitate Alum-sensing and humoral immunity
    Hemangi B Shah
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Leukoc Biol 92:883-93. 2012
    ..This may have important consequences for understanding the mechanism of action of Alum-containing vaccines...
  11. pmc IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine
    Elodie Mohr
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 107:17292-7. 2010
    ..Thus, T-bet dependence identifies distinct transcriptional pathways in B cells that regulate IFN-γ-induced switching to different IgG isotypes...
  12. pmc Pivotal advance: eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production
    Hai Bin Wang
    Department of Medicine, Harvard Medical School, Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center, Boston MA, 02215, USA
    J Leukoc Biol 83:817-21. 2008
    ....
  13. ncbi Mechanism of action of clinically approved adjuvants
    Bart N Lambrecht
    Department of Respiratory Diseases, University of Ghent, De Pintelaan, Belgium
    Curr Opin Immunol 21:23-9. 2009
    ..How exactly these pathways interact remains to be determined...
  14. ncbi A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria-tetanus-pertussis vaccine
    Toshiyuki Sugai
    Department of Pediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Vaccine 23:5450-6. 2005
    ..These data suggested new applications of CpG-ODN as adjuvants in DPT vaccine...
  15. pmc Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88
    Anja Seubert
    Novartis Vaccines and Diagnostics, 53100 Siena, Italy
    Proc Natl Acad Sci U S A 108:11169-74. 2011
    ..Because MF59 did not activate any of the Toll-like receptors in vitro, we propose that MF59 requires MyD88 for a Toll-like receptor-independent signaling pathway...
  16. pmc Single and combination herpes simplex virus type 2 glycoprotein vaccines adjuvanted with CpG oligodeoxynucleotides or monophosphoryl lipid A exhibit differential immunity that is not correlated to protection in animal models
    Tansi Khodai
    Internal Medicine Research Unit, Pfizer Research and Development, Sandwich, UK
    Clin Vaccine Immunol 18:1702-9. 2011
    ..We conclude that difficulties in correlating immune responses to efficacy in animal models will act as a deterrent to researchers attempting to develop effective HSV vaccines...
  17. pmc Disparate adjuvant properties among three formulations of "alum"
    Derek W Cain
    Department of Immunology, Duke University, Durham, NC 27710, USA
    Vaccine 31:653-60. 2013
    ....
  18. ncbi Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Immunol 181:3755-9. 2008
    ..We propose that, in addition to TLR stimulators, agonists of the NALP3 inflammasome should also be considered as vaccine adjuvants...
  19. ncbi Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella
    Karine Serre
    MRC Centre for Immune Regulation, University of Birmingham, Medical School, Birmingham, UK
    Mol Immunol 45:3558-66. 2008
    ..Finally, IL-17RB is strongly associated with OVA-specific CD4 T cells responding to alumOVA, suggesting that alum may promote Th2 immune response through a role for the IL-25/IL-17RB pathway...
  20. ncbi Vaccine adjuvants: current state and future trends
    Nikolai Petrovsky
    Autoimmunity Research Unit, ANU Medical School, Australian National University, Canberra, ACT 2061, Australia
    Immunol Cell Biol 82:488-96. 2004
    ..This paper reviews the state of the art in the adjuvant field, explores future directions of adjuvant development and finally examines some of the impediments and barriers to development and registration of new human adjuvants...
  21. ncbi Responses to multiple injections with alum alone compared to injections with alum adsorbed to proteins in mice
    Xuan Yi Wang
    Key Laboratory of Molecular Medical Virology, MOE MOH, Shanghai Medical College, Fudan University, Shanghai, PR China
    Immunol Lett 149:88-92. 2013
    ....
  22. ncbi The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants
    Roberto Spreafico
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, Singapore
    Eur J Immunol 40:638-42. 2010
    ..Could this be the basis of a long-needed rationale in the design of adjuvants?..
  23. pmc Phase I testing of a malaria vaccine composed of hepatitis B virus core particles expressing Plasmodium falciparum circumsporozoite epitopes
    Elizabeth H Nardin
    New York University School of Medicine, Department of Medical and Molecular Parasitology, 341 East 25th St, New York, NY 10010, USA
    Infect Immun 72:6519-27. 2004
    ....
  24. ncbi CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
    H L Davis
    Loeb Research Institute, Ottawa Civic Hospital, ON, Canada
    J Immunol 160:870-6. 1998
    ..These studies demonstrate that CpG ODN are promising new immune enhancers for vaccination applications...
  25. pmc IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia
    Yoshihiro Ueda
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 182:6477-84. 2009
    ..Thus, IL-1 plays a necessary, but indirect, role in the support of alum-induced neutrophilias by expanding both pluripotent and myeloid progenitor compartments to accelerate granulopoiesis...
  26. ncbi The artificial antimicrobial peptide KLKLLLLLKLK induces predominantly a TH2-type immune response to co-injected antigens
    Jörg H Fritz
    Intercell AG, Campus Vienna Biocenter 6, 1030 Vienna, Austria
    Vaccine 22:3274-84. 2004
    ..We provide evidence that KLKL5KLK enhances the association of antigen to antigen-presenting cells and forms a depot of antigen at the site of injection, making it an interesting adjuvant for novel vaccine design...
  27. ncbi Eco-friendly and efficient one-pot synthesis of alkyl- or aryl-14H-dibenzo[a,j]xanthenes in water
    Minoo Dabiri
    Department of Chemistry, Faculty of Science, Shahid Beheshti University, Postal Code 1983963113, Evin, Tehran, Iran
    Bioorg Med Chem Lett 18:436-8. 2008
    ..Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent...
  28. ncbi Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants
    Vishukumar Aimanianda
    Aspergillus Unit, Institut Pasteur, Paris F 75015, France
    Trends Pharmacol Sci 30:287-95. 2009
    ..These novel cellular and molecular mechanisms of aluminum salts are likely to influence how we design effective and safe adjuvants in the future...
  29. ncbi Vitamin E protection from testicular damage caused by intraperitoneal aluminium
    Recep Kutlubay
    Department of Histology and Embryology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    Int J Toxicol 26:297-306. 2007
    ..The associated biochemical parameters merit further investigation...
  30. pmc IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo
    Karine Serre
    MRC Centre for Immune Regulation, The IBR, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Mol Immunol 47:1914-22. 2010
    ....
  31. ncbi Effects of aluminum sulfate on erythropoiesis in rats
    M Farina
    Curso de Farmácia, Centro de Ciencias da Saude, Universidade Regional Integrada Campus de Erechim, 99700 000 Erechim, RS, Brazil
    Toxicol Lett 132:131-9. 2002
    ..Renal and cerebral aluminum concentrations did not vary between groups. The present results indicate that exposure to aluminum sulfate promotes signs of anemia in rats as a consequence of alterations in iron status...
  32. ncbi Histological and ultrastructural evidence for protective effects on aluminium-induced kidney damage by intraperitoneal administration of alpha-tocopherol
    Recep Kutlubay
    Department of Histology and Embryology, Faculty of Medicine, Pamukkale University, Ankara, Turkey
    Int J Toxicol 26:95-101. 2007
    ..At the same time, the maintenance of a diet that is rich in vitamin E should be beneficial in the alleviation of Al toxicity...
  33. ncbi In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to freund's complete adjuvant, but continues to induce T helper 2 cytokine production
    J M Brewer
    Department of Immunology, University of Strathclyde, Glasgow, Scotland
    Eur J Immunol 26:2062-6. 1996
    ..However, although production of the Th2 cytokine IL-5 was totally inhibited in IL-4-deficient mice inoculated with FCA/OVA, there was no significant difference in IL-5 production between the two strains when alum was used as adjuvant...
  34. ncbi Amelioration of aluminium-induced liver damage by vitamin E
    Recep Kutlubay
    Department of Histology and Embryology, Kinikli, Denizli, Turkey
    Saudi Med J 28:197-200. 2007
    ..To investigate the effects of aluminium sulphate on the microscopic morphology of the liver and on vitamin E amelioration of aluminium-induced liver damage...
  35. ncbi Immunology of TLR-independent vaccine adjuvants
    Ennio De Gregorio
    Novartis Vaccines and Diagnostics, Siena, Italy
    Curr Opin Immunol 21:339-45. 2009
    ..These findings highlight that the activation of DCs plays a central role in the mechanism of action of all classes of vaccine adjuvants but can occur by a multitude of different pathways and cellular interactions...
  36. pmc Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses
    Silvia B Boscardin
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:599-606. 2006
    ..We conclude that antigen targeting to DCs combined with a maturation stimulus produces broad-based and long-lived T cell help for humoral immune responses...
  37. ncbi Physico-chemical treatment of Merida landfill leachate for chemical oxygen demand reduction by coagulation
    Roger I Méndez-Novelo
    Environmental Engineering, School of Civil Engineering, Autonomous University of Yucatan, Yucatan, Mexico
    Waste Manag Res 23:560-4. 2005
    ..Finally a greater than 90% removal of organic material, measured as suspended COD, was obtained at pH 2, which was considered as the optimal value...
  38. ncbi Simulation of pulp mill wastewater recycling after tertiary treatment
    V Fontanier
    INP ENSIACET, Laboratoire de Chimie Agro Industrielle, Equipe Génie Chimique, Toulouse, France
    Environ Technol 26:1335-44. 2005
    ..Chloride and sulfate ions which could cause corrosion should also be removed...
  39. ncbi Comments on "Removal of aluminium by constructed wetlands with water hyacinth (Eichhornia crassipes (Mart.) Solms) grown under different nutritional conditions"
    Caetano C Dorea
    J Environ Sci Health A Tox Hazard Subst Environ Eng 43:111; author reply 112. 2008
  40. ncbi Coagulation and precipitation as post-treatment of anaerobically treated primary municipal wastewater
    Evan Diamadopoulos
    Department of Environmental Engineering, Technical University of Crete, 73100 Chania, Greece
    Water Environ Res 79:131-9. 2007
    ..Finally, size fractionation of the organic matter (COD) showed that the various treatment methods were capable of removing different fractions of the organic matter...
  41. ncbi Di-(2-ethylhexyl) phthalate is without adjuvant effect in mice on ovalbumin
    Rebecca Jane Dearman
    Faculty of Life Sciences, Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Toxicology 244:231-41. 2008
    ..Topical application of concentrations of DEHP that provoked marked systemic effects was without effect on the induction of immune responses...
  42. ncbi Colloidal silica removal in coagulation processes for wastewater reuse in a high-tech industrial park
    S H Chuang
    Department of Environmental Engineering and Management, Chaoyang University of Technology, Wufeng, Taichung County 413, Chinese Taiwan
    Water Sci Technol 55:187-95. 2007
    ..The combined PACl/PAA/flocs coagulation was effective for the removal of colloidal silica, soluble COD, and turbidity and also suitable as a pretreatment unit in wastewater reclamation and reuse processes...
  43. ncbi Co-conditioning of the anaerobic digested sludge of a municipal wastewater treatment plant with alum sludge: benefit of phosphorus reduction in reject water
    Y Yang
    Centre for Water Resources Research, School of Architecture, Landscape and Civil Engineering, University College Dublin, Ireland
    Water Environ Res 79:2468-76. 2007
    ..However, for its full-scale application, integrated cost-effective analysis of process capabilities, sludge transport, increased cake disposal, additional administration, polymer saving, and so on, should be factored in...
  44. ncbi The exploration of potassium ferrate(VI) as a disinfectant/coagulant in water and wastewater treatment
    Jia Qian Jiang
    School of Engineering C5, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom
    Chemosphere 63:212-9. 2006
    ..Also, potassium ferrate(VI) can produce less sludge volume and remove more pollutants, which could make sludge treatment easier...
  45. ncbi The application of potassium ferrate for sewage treatment
    Jia Qian Jiang
    School of Engineering C5, University of Surrey, Guildford, Surrey GU2 7XH, UK
    J Environ Manage 79:215-20. 2006
    ..Also, potassium ferrate(VI) produces less sludge volume and removes more contaminants, which should make subsequent sludge treatment easier...
  46. ncbi Colour removal from model solutions by coagulation--surface charge and floc characterisation aspects
    S Gaydardzhiev
    Lehrstuhl Aufbereitungstechnik, Brandenburg Technical University, Siemens Halske Ring 8, 03046 Cottbus, Germany
    Environ Technol 27:193-9. 2006
    ..Finally, flocs from selected sludge samples have been examined for particle size and shape by image analysis and their key characteristics summarised...
  47. ncbi Enhanced separation of water quality parameters in the DAF (Dissolved Air Flotation) system using ozone
    Byoung Ho Lee
    Civil and Environmental Engineering, University of Ulsan, Korea
    Water Sci Technol 56:149-55. 2007
    ..3% more in the DOF system. Separation capability of the DOF system was greatly enhanced for most of the water quality parameters because ozone provides strong oxidation power with large volume of micro-bubbles...
  48. ncbi Evaluation of coagulation-flocculation on a COD-based molecular size distribution for a textile finishing mill effluent
    Hijlal Uner
    Istanbul Technical University, Faculty of Civil Engineering, Environmental Engineering Department, Maslak, Istanbul, Turkey
    J Environ Sci Health A Tox Hazard Subst Environ Eng 41:1899-908. 2006
    ..The effect of optimum treatment alternatives on the chemical oxygen demand (COD) values of different molecular weight cut-off fractions was also examined...
  49. ncbi Use of chemical coagulants to control fouling potential for wastewater membrane bioreactor processes
    Fengshen Fan
    School of Engineering, University of Guelph, Guelph, Ontario, Canada
    Water Environ Res 79:952-7. 2007
    ....
  50. ncbi Combining ultrafiltration process with coagulation pretreatment for pulp mill wastewater treatment
    Y S Hong
    School of Engineering, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Environ Technol 28:995-1006. 2007
    ....
  51. ncbi Suspended particle destabilization in retained urban stormwater as a function of coagulant dosage and redox conditions
    John J Sansalone
    Department of Civil and Environmental Engineering, University of Florida, 216 Black Hall, Gainesville, FL 32611, USA
    Water Res 42:909-22. 2008
    ..Results have significant implications for BMPs that retain runoff between events...
  52. ncbi Phosphorus treatment of secondary municipal effluent using oven-dried alum residual
    Md M Mortula
    Centre for Sustainable Infrastructure Research, National Research Council Canada, Regina, Canada
    J Environ Sci Health A Tox Hazard Subst Environ Eng 42:1685-91. 2007
    ..Oven-dried alum residuals were also able to adsorb organic matter. The results indicated that oven-dried alum residuals have potential to provide a low cost technological solution for small- and medium-sized municipalities...
  53. ncbi Soluble phosphorus removal through adsorption on spent alum sludge
    D A Georgantas
    Laboratory of Chemical Process Engineering, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, GR 15780 Zografos, Athens, Greece
    Environ Technol 27:1081-8. 2006
    ..Finally, equilibrium was studied for fresh and aged spent alum sludge and the Freundlich isotherm fitted best the experimental data suggesting heterogeneous sorption [K(F)=14.4-19.7, N: 0.13-0.200]...
  54. ncbi A pilot-scale evaluation of magnetic ion exchange treatment for removal of natural organic material and inorganic anions
    Treavor H Boyer
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, 27599 7431, USA
    Water Res 40:2865-76. 2006
    ..Increasing the sulfate concentration resulted in decreased removal of UV-absorbing substances, DOC, and bromide. Consistent results were observed between the continuous-flow pilot plant tests and batch equilibrium studies...
  55. ncbi [Effect of reaction conditions on the removal of pathogenic protozoan from secondary effluent in flocculation process]
    Tong Zhang
    Environmental Simulation and Pollution Control State Key Joint Laboratory, Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China
    Huan Jing Ke Xue 28:1752-8. 2007
    ..The effectiveness increased with the increase of ferric chloride dosage. Aluminium sulphate and poly aluminium chloride gave better performance in removal of pathogenic protozoan at the dosage of 70 mg/L and 20 mg/L respectively...
  56. ncbi Effects of velocity gradient and mixing time on particle growth in a rapid mixing tank
    S M Park
    Department of Environmental Engineering, Chungbuk National University, Korea
    Water Sci Technol 53:95-102. 2006
    ..Growth and break of particles and flocs in a rapid mixing step would influence significantly on the sequential flocculation and sedimentation processes for turbidity removal...
  57. ncbi The effect of ozonation on natural organic matter removal by alum coagulation
    Purnendu Bose
    Department of Civil Engineering, Indian Institute of Technology, Environmental Engineering and Management Programme, Kanpur, India
    Water Res 41:1516-24. 2007
    ..A strategy for staged coagulation with intermediate ozonation was proposed for waters containing both humic and non-humic NOM for maximum DOC and specific UV absorbance at 254nm (SUVA) removal...
  58. ncbi Treatment of composite wastewater of a cotton textile mill by thermolysis and coagulation
    Pradeep Kumar
    Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee 247667, India
    J Hazard Mater 151:770-9. 2008
    ..The sludge thus produced would contain lower inorganic mass coagulant and can be used as a solid fuel with high calorific value of about 16 MJ/kg, close to that of Indian coal...
  59. ncbi Removal of boron (B) from waste liquors
    J Q Jiang
    School of Engineering, University of Surrey, Guildford, UK
    Water Sci Technol 53:73-9. 2006
    ..e. removing 150 g of boron from 1 m3 of effluent, electrocoagulation was 6.2 times cheaper than alum coagulation. The economic advantage of electrocoagulation in the treatment of boron-containing waste effluent is thus significant...
  60. ncbi Dynamic analysis of coagulation of low turbidity water sources using Al- and Fe-based coagulants
    K Ebie
    Department of Civil Engineering, Kitami Institute of Technology 165 Koen cho, Kitami, Hokkaido, 090 8507, Japan
    Water Sci Technol 53:67-74. 2006
    ....
  61. ncbi Enhanced desensitization efficacy by liposomal conjugation of a specific antigen
    K Ichikawa
    Department of Medical Biochemistry and COE Program in the 21st Century, University or Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 336:391-5. 2007
    ..v. injection. These results suggest that the liposomal OVA effectively interacts with and desensitizes immune cells, therefore, liposomes coupling with a certain antigen may be effective in allergy immunotherapy...
  62. ncbi The effect of coagulation on the toxicity and mutagenicity of reclaimed municipal effluents
    M Petala
    Department of Chemical Engineering, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece
    Chemosphere 65:1007-18. 2006
    ..However, the addition of aluminum coagulants resulted in a decrease of mutagenic potential of secondary effluents, due to the extended removal of organic matter...
  63. ncbi Decolorization and COD reduction of dyeing wastewater from a cotton textile mill using thermolysis and coagulation
    Pradeep Kumar
    Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee, India
    J Hazard Mater 153:635-45. 2008
    ..The sludge thus produced would contain lower inorganic mass coagulant and, therefore, less amount of inorganic sludge...
  64. ncbi The use of alum, ferric chloride and ferrous sulphate as coagulants in removing suspended solids, colour and COD from semi-aerobic landfill leachate at controlled pH
    Hamidi Abdul Aziz
    School of Civil Engineering, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang, Malaysia
    Waste Manag Res 25:556-65. 2007
    ..The results indicate that coagulation and flocculation processes can be used effectively in integrated semi-aerobic leachate treatment systems, especially for removing suspended solids, colour and COD...
  65. ncbi Assessment of electrochemical and chemical coagulation as post-treatment for the effluents of a UASB reactor treating cellulose pulp mill wastewater
    A P Buzzini
    Department of Hydraulics and Sanitation, School of Engineering of São Carlos, University of Sao Paulo, Brazil
    Water Sci Technol 52:183-8. 2005
    ..The addition of a high molecular weight cationic polymer enhanced both COD and color removal. Both post-treatment processes are technically feasible...
  66. ncbi Monitoring floc formation and breakage
    J Gregory
    Department of Civil and Environmental Engineering, University College London, London, WC1E 6BT, UK
    Water Sci Technol 50:163-70. 2004
    ..This is in marked contrast to the action of a cationic polyelectrolyte, where floc breakage is almost completely reversible. Some possible reasons for these observations are discussed, but, so far, there is no adequate model available...
  67. pmc Evaluation of recombinant Onchocerca volvulus activation associated protein-1 (ASP-1) as a potent Th1-biased adjuvant with a panel of protein or peptide-based antigens and commercial inactivated vaccines
    Wenjun Xiao
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    Vaccine 26:5022-9. 2008
    ....
  68. ncbi Improvement of coagulation-flocculation process using anionic polyacrylamide as coagulant aid
    M I Aguilar
    Department of Chemical Engineering, University of Murcia Campus, Espinardo, 30071 Murcia, Spain
    Chemosphere 58:47-56. 2005
    ..Anionic polyacrylamide, when added with ferric sulphate or polyaluminium chloride led to a significant increase in the settling speed...
  69. ncbi Regulation of antigen-specific versus by-stander IgE production after antigen sensitization
    X Z Shang
    Centocor Inc, 200 Great Valley Parkway, Malvern, PA 19355, USA
    Cell Immunol 229:106-16. 2004
    ....
  70. ncbi Use of dewatered alum sludge as a substrate in reed bed treatment systems for wastewater treatment
    Y Q Zhao
    Centre for Water Resources Research, School of Architecture, Landscape and Civil Engineering, University College Dublin, Belfield, Dublin, Ireland
    J Environ Sci Health A Tox Hazard Subst Environ Eng 43:105-10. 2008
    ..This will help to make the alum sludge-based reed bed environmentally and economically justifiable...
  71. ncbi Selective coagulant recovery from water treatment plant residuals using Donnan membrane process
    Prakhar Prakash
    Department of Civil and Environmental Engineering, 13 East Packer Avenue, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Environ Sci Technol 37:4468-74. 2003
    ..DMP was also found equally effective in recovering Fe(III) based coagulants from WTR...
  72. ncbi Coagulation-flocculation pretreatment of sanitary landfill leachates
    A A Tatsi
    Department of Chemistry, Division of Chemical Technology, Aristotle University of Thessaloniki, Thessaloniki GR 541 24, Greece
    Chemosphere 53:737-44. 2003
    ..The physico-chemical process may be used as a useful pretreatment step, especially for fresh leachates, prior to biological treatment, or as a post-treatment (polishing) step for partially stabilized leachates...
  73. ncbi A study on arsenic removal from household drinking water
    Tao Yuan
    Centre for Water Research, Department of Civil Engineering, National University of Singapore, Singapore
    J Environ Sci Health A Tox Hazard Subst Environ Eng 38:1731-44. 2003
    ..The results obtained from field experiment demonstrated that the method of ferric sulfate coagulation/sand filtration for arsenic removal from household drinking water was acceptable and affordable...
  74. ncbi Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100
    Dante J Marciani
    Galenica Pharmaceuticals Inc, 2800 Milan Court, Suite 118, Birmingham, AL 35211, USA
    Vaccine 21:3961-71. 2003
    ..UFGPI-0100 was free of acylated quillaja saponin components, including the more stable QS-7...
  75. ncbi Major royal jelly protein 3 modulates immune responses in vitro and in vivo
    Iwao Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, 702 8006 Okayama, Japan
    Life Sci 73:2029-45. 2003
    ..Furthermore, considering the intriguing immunomodulatory effects of MRJP3, it may be of clinical significance to design MRJP3-derived antiallergic peptides by identifying the associated polypeptide regions...
  76. ncbi Dissolved organic nitrogen removal during water treatment by aluminum sulfate and cationic polymer coagulation
    Wontae Lee
    HDR Engineering, Inc, 3200 East Camelback Road Suite 350, Phoenix, AZ 85018, USA
    Water Res 40:3767-74. 2006
    ..Results indicated that the DON added as part of the cationic polymer was almost completely removed at optimum aluminum sulfate and polymer doses...
  77. ncbi Effect of charge neutralization on the dewatering performance of alum sludge by polymer conditioning
    C C Wu
    Department of Environmental Engineering and Science Feng Chia University Taichung, Taiwan
    Water Sci Technol 44:315-9. 2001
    ..Such open floc structure can be attributed to the lack of charge neutralization as the flocs aggregate with anionic polymer...
  78. ncbi Potential and limitations of alum or zeolite addition to improve the performance of a submerged membrane bioreactor
    J C Lee
    School of Chemical Engineering, Seoul National University, Seoul 151-742, Korea
    Water Sci Technol 43:59-66. 2001
    ..In particular, the nitrification efficiency was over 95% even at N-shock loading due to the ion-exchange capacity of zeolite. The mechanisms for improved membrane permeability through alum or zeolite addition were discussed in detail...
  79. ncbi Temperature effects on flocculation, using different coagulants
    C S B Fitzpatrick
    Department of Civil and Environmental Engineering, University College London, London WC1E 6BT, UK
    Water Sci Technol 50:171-5. 2004
    ..Recovery after increased shear is greater at lower temperatures implying that floc break-up is more reversible for lower temperatures...
  80. ncbi Optimization of phosphorus removal from secondary effluent using simplex method in Tianjin, China
    Yuqiu Wang
    College of Environmental Science and Engineering, Nankai University, Tianjin, China
    J Hazard Mater 121:183-6. 2005
    ..3, 95.6 and 94.0%, respectively, and the minimum total phosphorus residual was 0.35, 0.12 and 0.16 mg/L, respectively...
  81. ncbi Particle count and size alteration for membrane fouling reduction in non-conventional water filtration
    A Adin
    The Hebrew University of Jerusalem, Jerusalem, Israel 91904
    Water Sci Technol 50:273-8. 2004
    ..Coagulation enhanced the removal of small size particles, a positive impact on reducing membrane fouling potential...
  82. ncbi Enhanced removal of heavy metals in primary treatment using coagulation and flocculation
    Pauline D Johnson
    University of Alabama, Department of Civil Construction and Environmental Engineering, 7th Ave and Campus Drive, 260 H M Comer, Tuscaloosa, Alabama 35487, USA
    Water Environ Res 80:472-9. 2008
    ..Efficient metals capture during CEPT can result in increased allowable headworks loadings or lower metal levels in the outfall...
  83. ncbi Stability and removal of water soluble CdTe quantum dots in water
    Yang Zhang
    Department of Civil and Environmental Engineering, Arizona State University, Tempe, Arizona 85287 5306, USA
    Environ Sci Technol 42:321-5. 2008
    ..Divalent cations (Mg2+ and Ca2+) in tap water induce the formation of settleable QD flocs such that 70-80% of the QGDs by mass settle out...
  84. ncbi Bench-scale testing of a magnetic ion exchange resin for removal of disinfection by-product precursors
    Treavor H Boyer
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Rosenau Hall, CB 7431, Chapel Hill, NC 27599, USA
    Water Res 39:1265-76. 2005
    ..MIEX also removed bromide to varying degrees, depending on the raw water alkalinity and initial bromide ion concentration...
  85. ncbi Comparison between biological and chemical treatment of wastewater containing nitrogen and phosphorus
    Ebtesam El-Bestawy
    Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, El Shatby, Alexandria, Egypt
    J Ind Microbiol Biotechnol 32:195-203. 2005
    ..Thus, integration between the proposed chemical and biological treatment is highly recommended, producing high-quality effluents acceptable by the environmental law...
  86. ncbi Inactivation of particle-associated viral surrogates by ultraviolet light
    Michael R Templeton
    Department of Civil Engineering, University of Toronto, Toronto, Ont, Canada M5S 1A4
    Water Res 39:3487-500. 2005
    ..g. UV-absorbing organic content) may be a critical factor in the survival of particle-associated viruses during UV disinfection...
  87. ncbi Breakage, regrowth, and fractal nature of natural organic matter flocs
    Peter Jarvis
    School of Water Sciences, Cranfield University, Cranfield, Bedford MK40 0AL, United Kingdom
    Environ Sci Technol 39:2307-14. 2005
    ..This provided a possible mechanistic reason for the irreversible breakage seen...
  88. ncbi Effect of NOM, turbidity and floc size on the PAC adsorption of MIB during alum coagulation
    Lionel Ho
    Australian Water Quality Centre, a partner in the Cooperative Research Centre for Water Quality and Treatment, PMB 3, Salisbury, SA 5108, Australia
    Water Res 39:3668-74. 2005
    ..The presence of turbidity also reduced MIB adsorption due to the formation of larger flocs. The character of NOM was found to have a greater influence on the adsorption of MIB than the floc structure...
  89. pmc Calcium phosphate nanoparticle adjuvant
    Q He
    BioSante Pharmaceuticals, Inc, Smyrna, Georgia 30082, USA
    Clin Diagn Lab Immunol 7:899-903. 2000
    ..benefits of CAP include (i) an insignificant IgE response, which is an important advantage over injection of alum compounds, and (ii) the fact that CAP is a natural constituent of the human body...
  90. ncbi Aluminum potassium sulfate and tannic acid (ALTA) injection as the mainstay of treatment for internal hemorrhoids
    Yoshikazu Hachiro
    Department of Proctology, Kunimoto Hospital, 1 7 Akebono, Asahikawa, 079 0061, Japan
    Surg Today 41:806-9. 2011
    ..Aluminum potassium sulfate and tannic acid (ALTA) induce noninvasive sclerosis and the involution of hemorrhoids by initiating an inflammatory reaction. We assessed the mid-term outcome after ALTA sclerotherapy for symptomatic hemorrhoids...
  91. ncbi Regular consumption of a silicic acid-rich water prevents aluminium-induced alterations of nitrergic neurons in mouse brain: histochemical and immunohistochemical studies
    E Foglio
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy
    Histol Histopathol 27:1055-66. 2012
    ....
  92. pmc Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects
    Eric Dumonteil
    Laboratorio de Parasitología Centro De Investigaciones Regional, Dr Hideo Noguchi Autonomous University of Yucatan UADY, Merida, Mexico
    Expert Rev Vaccines 11:1043-55. 2012
    ....
  93. ncbi A preliminary evaluation of alternative adjuvants to alum using a range of established and new generation vaccine antigens
    Manmohan Singh
    Vaccines Research, Chiron Vaccines, 4560 Horton St, M S 4 3, Emeryville, CA 94608, USA
    Vaccine 24:1680-6. 2006
    ..The study indicates that it is possible to replace alum with other adjuvant formulations like MF59 and PLG and maintain and/or improve immune responses with some vaccine antigens...
  94. ncbi Toxicity detection of sodium nitrite, borax and aluminum potassium sulfate using electrochemical method
    Dengbin Yu
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
    J Environ Sci (China) 25:785-90. 2013
    ..coli after being incubated for 3 hr with the toxic compound in buffer solutions. The electrochemical method is expected to be a sensitive and simple alternative to toxicity screening for chemical food additives...
  95. ncbi Immunogenicity of a recombinant envelope domain III protein of dengue virus type-4 with various adjuvants in mice
    J Pradeep Babu
    Division of Virology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Vaccine 26:4655-63. 2008
    ....
  96. pmc β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma
    Anton Volkov
    Institute for Medical Microbiology and Hygiene, Philipps University of Marburg, Marburg, Germany
    PLoS ONE 8:e60565. 2013
    ..Here, we present novel evidence for the requirement of the β5i immunosubunit to generate a strong Th2 response during OVA- but not HDM-induced acute asthma. The unexpected role of β5i in OVA asthma remains to be clarified...
  97. pmc Mucosal priming of newborn mice with S. Typhi Ty21a expressing anthrax protective antigen (PA) followed by parenteral PA-boost induces B and T cell-mediated immunity that protects against infection bypassing maternal antibodies
    Karina Ramirez
    Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, 685 West Baltimore St Room 480, Baltimore, MD 21201, USA
    Vaccine 28:6065-75. 2010
    ..Mucosal priming with a safe and effective S. Typhi-based anthrax vaccine followed by PA-boost could serve as a practical and effective prophylactic approach to prevent anthrax early in life...
  98. ncbi Occurrence and treatment of wastewater-derived organic nitrogen
    Baiyang Chen
    School of Civil and Environmental Engineering, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, PR China
    Water Res 45:4641-50. 2011
    ..PAC adsorption preferentially removed more DOC than DON by 10% on average. The results provided herein hence shed light on approaches for reducing organic nitrogen content in treated wastewater...
  99. ncbi Protective anti-mycobacterial T cell responses through exquisite in vivo activation of vaccine-targeted dendritic cells
    Arun T Kamath
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
    Eur J Immunol 38:1247-56. 2008
    ..Thus, potent protective IFN-gamma-producing responses may be elicited by the exquisite activation of a minute number of in vivo targeted DC...
  100. ncbi Pretreatment of wastewater containing a mixture of organic pollutants obtained from a CC2 plant by coagulation
    Bidhan C Bag
    Process Technology Development Division, Defence Research and Development Establishment, Ministry of Defence, Government of India, Jhansi Road, Gwalior, 474 002, India
    Water Sci Technol 58:1071-7. 2008
    ..0. After coagulation the concentration of pyridine in wastewater was found to be reduced by 10.0% and that of DPU 40-45% with a dosage of 500 mg L(-1) alum...
  101. ncbi Induction of HIV-1 MPR(649-684)-specific IgA and IgG antibodies in caprine colostrum using a peptide-based vaccine
    Stephanie M Dorosko
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Vaccine 26:5416-22. 2008
    ..These results support the concept that a peptide vaccine can effectively induce MPR(649-684)-specific sIgA and IgG in the colostrum of a lactating species...

Research Grants16

  1. derG Immunostimulant Prevention/Treatment of HSV Disease
    Daniel Zimmerman; Fiscal Year: 2003
    ..An integral part of the phase II program will be to further elucidate the target cells and mechanism of action of derG. ..
  2. ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
    David Abraham; Fiscal Year: 2005
    ..stercoralis and in addition we will determine the role of these cells in the transition from the innate to the adaptive immune response to this infection. ..
  3. ANTIIDIOTYPE VACCINE THERAPY OF HUMAN COLORECTAL CANCER
    MALAYA CHATTERJEE; Fiscal Year: 2002
    ..These studies will be a prelude to clinical trials for CRC patients with autologous DC based anti-Id vaccine and scFv. ..
  4. Immunogenicity of Synthetic Peptide Malaria Vaccines
    Elizabeth Nardin; Fiscal Year: 2009
    ..abstract_text> ..
  5. Global GAS Vaccine Based On The M-Protein
    Michael Good; Fiscal Year: 2008
    ..abstract_text> ..
  6. Oxygen and Phototherapy in perinatal period: Risk of Acute Lymphoctyic Leukemia
    Nigel Paneth; Fiscal Year: 2008
    ..If these treatments increase the risk of leukemia, it should be possible to find alternative ways to manage newborn problems that minimize exposure to these treatments [unreadable] [unreadable] [unreadable]..
  7. Sixth International Respiratory Syncytial Virus Symposium
    ANN FALSEY; Fiscal Year: 2007
    ..abstract_text> ..
  8. Development of a Global GBS Vaccine
    LAWRENCE PAOLETTI; Fiscal Year: 2007
    ..This work will lead to a vaccine effective in preventing GBS diseases worldwide. ..
  9. Rational Design of Therapeutic Vaccines for CEA+ Tumors
    SUNIL CHATTERJEE; Fiscal Year: 2007
    ..The results obtained from these studies will help design improved therapeutic vaccines for the treatment of CEA+ tumors and can be incorporated readily into our ongoing clinical programs. ..
  10. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006
    ..abstract_text> ..
  11. T Cell Epitopes of the Malaria Circumsporozoite Proteins
    Elizabeth Nardin; Fiscal Year: 2007
    ..falciparum vaccines and (2) evaluation of anti-P, falciparum repeat immune responses elicited in human volunteers immunized with malaria vaccines. ..
  12. Bacterial Vaccine Antigen Discovery
    LAWRENCE PAOLETTI; Fiscal Year: 2006
    ..Aim 2). Findings from these studies utilizing this unique approach to vaccine antigen discovery could be directly applied to other bacterial pathogens. ..
  13. HER 2/Neu--A Target For Cancer Immunotherapy
    MALAYA CHATTERJEE; Fiscal Year: 2005
    ..This study will be a prelude to clinical trials for HER2/neu positive cancer patients with a single or combined anti-Id vaccine. ..
  14. Peptide Vaccine for Experimental Autoimmune Myocarditis
    Daniel Zimmerman; Fiscal Year: 2003
    ..The effects of J-My-1 administration on the presence and frequency of this cell type will be evaluated. Our goal is to demonstrate that the severity of EAM can be reduced by J-My-1 administration in animals with EAM. ..
  15. Augmenting innate and vaccine immune response with der-G
    Daniel Zimmerman; Fiscal Year: 2003
    ..In these studies we will follow survival and ovarian viral titers after intranasal challenge with VV. The studies will also analyze the mechanism of action to identify immune surrogates for use in clinical studies. ..
  16. New Paradigms of Cerebral Palsy Etiology: A Comprehensive Case Control Study
    NIGEL SEFTON PANETH; Fiscal Year: 2010
    ..Maternal interviews and birth certificates will inform the above analyses by linking molecular information to self-reported and recorded clinical events and conditions. ..