acids

Summary

Summary: Chemical compounds which yield hydrogen ions or protons when dissolved in water, whose hydrogen can be replaced by metals or basic radicals, or which react with bases to form salts and water (neutralization). An extension of the term includes substances dissolved in media other than water. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. ncbi Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms
    James C Orr
    Laboratoire des Sciences du Climat et de l Environnement, UMR CEA CNRS, CEA Saclay, F 91191 Gif sur Yvette, France
    Nature 437:681-6. 2005
  2. pmc A TRPA1-dependent mechanism for the pungent sensation of weak acids
    Yuanyuan Y Wang
    Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA
    J Gen Physiol 137:493-505. 2011
  3. pmc Transcriptomic analysis of Escherichia coli O157:H7 and K-12 cultures exposed to inorganic and organic acids in stationary phase reveals acidulant- and strain-specific acid tolerance responses
    Thea King
    CSIRO Food and Nutritional Sciences, Brisbane, Queensland, Australia
    Appl Environ Microbiol 76:6514-28. 2010
  4. doi Chemical equilibrium modeling of organic acids, pH, aluminum, and iron in Swedish surface waters
    Carin S Sjöstedt
    Department of Land and Water Resources Engineering, KTH Royal Institute of Technology, Teknikringen, Stockholm, Sweden
    Environ Sci Technol 44:8587-93. 2010
  5. ncbi Generic and specific transcriptional responses to different weak organic acids in anaerobic chemostat cultures of Saccharomyces cerevisiae
    Derek A Abbott
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    FEMS Yeast Res 7:819-33. 2007
  6. ncbi Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity
    J W Fluhr
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 117:44-51. 2001
  7. ncbi Measurement of 18 perfluorinated organic acids and amides in human serum using on-line solid-phase extraction
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 77:6085-91. 2005
  8. ncbi From acids to osmZ: multiple factors influence synthesis of the OmpF and OmpC porins in Escherichia coli
    L A Pratt
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Mol Microbiol 20:911-7. 1996
  9. ncbi The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and are similar to acidocalcisomes
    F A Ruiz
    Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA
    J Biol Chem 276:46196-203. 2001
  10. pmc Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis
    Gautam Bhave
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Nat Chem Biol 8:784-90. 2012

Detail Information

Publications304 found, 100 shown here

  1. ncbi Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms
    James C Orr
    Laboratoire des Sciences du Climat et de l Environnement, UMR CEA CNRS, CEA Saclay, F 91191 Gif sur Yvette, France
    Nature 437:681-6. 2005
    ..Our findings indicate that conditions detrimental to high-latitude ecosystems could develop within decades, not centuries as suggested previously...
  2. pmc A TRPA1-dependent mechanism for the pungent sensation of weak acids
    Yuanyuan Y Wang
    Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA
    J Gen Physiol 137:493-505. 2011
    ..receptor mechanisms have been identified for many noxious chemicals, the mechanisms by which animals detect weak acids, such as acetic acid, are less well understood...
  3. pmc Transcriptomic analysis of Escherichia coli O157:H7 and K-12 cultures exposed to inorganic and organic acids in stationary phase reveals acidulant- and strain-specific acid tolerance responses
    Thea King
    CSIRO Food and Nutritional Sciences, Brisbane, Queensland, Australia
    Appl Environ Microbiol 76:6514-28. 2010
    ..Since little is known about the molecular basis of adaptation of E. coli to organic acids, we studied K-12 MG1655 and O157:H7 Sakai during exposure to acetic, lactic, and hydrochloric acid at pH 5.5...
  4. doi Chemical equilibrium modeling of organic acids, pH, aluminum, and iron in Swedish surface waters
    Carin S Sjöstedt
    Department of Land and Water Resources Engineering, KTH Royal Institute of Technology, Teknikringen, Stockholm, Sweden
    Environ Sci Technol 44:8587-93. 2010
    ..Soil gibbsite with a log *Ks of 8.29 at 25°C together with a pH dependent loading function that uses molar Al/C ratios describes the amount of aluminum in solution in the presence of organic matter if the pH is roughly above 6.0...
  5. ncbi Generic and specific transcriptional responses to different weak organic acids in anaerobic chemostat cultures of Saccharomyces cerevisiae
    Derek A Abbott
    Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
    FEMS Yeast Res 7:819-33. 2007
    Transcriptional responses to four weak organic acids (benzoate, sorbate, acetate and propionate) were investigated in anaerobic, glucose-limited chemostat cultures of Saccharomyces cerevisiae...
  6. ncbi Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity
    J W Fluhr
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 117:44-51. 2001
    ..corneum pH but also all of the functional abnormalities normalized when either palmitic, stearic, or linoleic acids were coapplied with the inhibitors...
  7. ncbi Measurement of 18 perfluorinated organic acids and amides in human serum using on-line solid-phase extraction
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 77:6085-91. 2005
    ..The high throughput and low limits of detection (0.05-0.8 ng/mL) using a small sample volume (100 microL of serum) and isotope dilution quantification make this method suitable for large-scale epidemiologic studies...
  8. ncbi From acids to osmZ: multiple factors influence synthesis of the OmpF and OmpC porins in Escherichia coli
    L A Pratt
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Mol Microbiol 20:911-7. 1996
    ....
  9. ncbi The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and are similar to acidocalcisomes
    F A Ruiz
    Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA
    J Biol Chem 276:46196-203. 2001
    ..Polyphosphate was also localized to the contractile vacuole by 4',6-diamidino-2-phenylindole staining, suggesting, with the immunochemical data, a link between these organelles and the acidocalcisomes...
  10. pmc Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis
    Gautam Bhave
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Nat Chem Biol 8:784-90. 2012
    ..Peroxidasin generates hypohalous acids as reaction intermediates, suggesting a paradoxically anabolic role for these usually destructive oxidants...
  11. doi Food availability outweighs ocean acidification effects in juvenile Mytilus edulis: laboratory and field experiments
    Jorn Thomsen
    GEOMAR Helmholtz Centre for Ocean Research, Kiel, Germany
    Glob Chang Biol 19:1017-27. 2013
    ....
  12. ncbi A proton-gated cation channel involved in acid-sensing
    R Waldmann
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Valbonne, France
    Nature 386:173-7. 1997
    ..The pain caused by acids is thought to be mediated by H+-gated cation channels present in sensory neurons...
  13. ncbi Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs
    Nao Yamakawa
    Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan
    Biochimie 89:1396-408. 2007
    ..Thus, 8-O-sulfation is dependent on the species, gametic cell-type, site-localization of the eggs, and glycoconjugates...
  14. pmc Quantitative proteomic analyses of the response of acidophilic microbial communities to different pH conditions
    Christopher P Belnap
    Microbiology Graduate Group, Department of Plant and Microbial Biology, University of California, Berkeley, CA, USA
    ISME J 5:1152-61. 2011
    ....
  15. ncbi Characterization of isolated acidocalcisomes of Trypanosoma cruzi
    D A Scott
    Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    J Biol Chem 275:24215-21. 2000
    ....
  16. doi Ocean acidification disrupts the innate ability of fish to detect predator olfactory cues
    Danielle L Dixson
    ARC Centre of Excellence for Coral Reef Studies, and School of Marine and Tropical Biology, James Cook University, Townsville, Qld 4811, Australia
    Ecol Lett 13:68-75. 2010
    ....
  17. ncbi The response to stationary-phase stress conditions in Escherichia coli: role and regulation of the glutamic acid decarboxylase system
    D De Biase
    Dipartimento di Scienze Biochimiche A Rossi Fanelli and Centro di Biologia Molecolare del Consiglio Nazionale delle Ricerche, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, 00185 Roma, Italy
    Mol Microbiol 32:1198-211. 1999
    ....
  18. doi Molecular characterization of the arginine deiminase system in Listeria monocytogenes: regulation and role in acid tolerance
    Sheila Ryan
    Department of Microbiology, University College Cork, Cork, Ireland
    Environ Microbiol 11:432-45. 2009
    ..Finally, using the murine model of infection, we have established a role for the ADI system in the virulence of L. monocytogenes...
  19. doi Volcanic carbon dioxide vents show ecosystem effects of ocean acidification
    Jason M Hall-Spencer
    Marine Institute, Marine Biology and Ecology Research Centre, University of Plymouth, Plymouth PL4 8AA, UK
    Nature 454:96-9. 2008
    ..Our results provide the first in situ insights into how shallow water marine communities might change when susceptible organisms are removed owing to ocean acidification...
  20. pmc Acid tolerance mechanisms utilized by Streptococcus mutans
    Robert Matsui
    Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, ON, M5G 1G6, Canada
    Future Microbiol 5:403-17. 2010
    ..The elucidation of these mechanisms will be discussed, serving as the focus of this review...
  21. pmc Replenishment of fish populations is threatened by ocean acidification
    Philip L Munday
    Australian Research Council Centre of Excellence for Coral Reef Studies and School of Marine and Tropical Biology, James Cook University, Townsville, Queensland 4811, Australia
    Proc Natl Acad Sci U S A 107:12930-4. 2010
    ..Our results show that additional CO(2) absorbed into the ocean will reduce recruitment success and have far-reaching consequences for the sustainability of fish populations...
  22. ncbi AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine
    Nadine Homeyer
    Abteilung für Bioinformatik, Institut fur Biochemie, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054, Erlangen, Germany
    J Mol Model 12:281-9. 2006
    We report a consistent set of AMBER force-field parameters for the most common phosphorylated amino acids, phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine in different protonation states...
  23. ncbi Fluoride and organic weak acids as modulators of microbial physiology
    Robert E Marquis
    Department of Microbiology and Immunology and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642 8672, USA
    FEMS Microbiol Rev 26:493-510. 2003
    ..are related to its weak-acid character, it is reasonable to compare fluoride action to those of organic weak acids, including metabolic acids, food preservatives, non-steroidal anti-inflammatory agents and fatty acids, all of ..
  24. pmc Escherichia coli glutamate- and arginine-dependent acid resistance systems increase internal pH and reverse transmembrane potential
    Hope Richard
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, 307 University Blvd, Mobile, AL 36688, USA
    J Bacteriol 186:6032-41. 2004
    ..Thus, reversing DeltaPsi may be a more important acid resistance strategy than maintaining a specific pHi value...
  25. pmc Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide view
    Nuno P Mira
    Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Technical University of Lisbon, Lisboa, Portugal
    OMICS 14:525-40. 2010
    Weak acids are widely used as food preservatives (e.g., acetic, propionic, benzoic, and sorbic acids), herbicides (e.g., 2,4-dichlorophenoxyacetic acid), and as antimalarial (e.g., artesunic and artemisinic acids), anticancer (e.g...
  26. ncbi Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source
    E R Boskey
    Thomas C.Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    Hum Reprod 16:1809-13. 2001
    ..CONCLUSIONS: Our results thus support the hypothesis that vaginal bacteria, not epithelial cells, are the primary source of lactic acid in the vagina...
  27. ncbi Escherichia coli acid resistance: tales of an amateur acidophile
    John W Foster
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA
    Nat Rev Microbiol 2:898-907. 2004
    ..Surprisingly, certain microorganisms that grow at neutral pH have elegantly regulated systems that enable survival during excursions into acidic environments. The best-characterized acid-resistance system is found in E. coli...
  28. pmc The small noncoding DsrA RNA is an acid resistance regulator in Escherichia coli
    Richard A Lease
    Wadsworth Center, New York State Department of Health, Center for Medical Sciences, Albany, New York, USA
    J Bacteriol 186:6179-85. 2004
    ..Whether DsrA targets acid resistance genes directly by base pairing or indirectly via perturbation of RpoS and/or H-NS is not known, but in either event, our results suggest that DsrA RNA may enhance the virulence of pathogenic E. coli...
  29. pmc The B1-subunit of the H(+) ATPase is required for maximal urinary acidification
    Karin E Finberg
    Departments of Genetics, Cellular and Molecular Physiology, Surgery, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:13616-21. 2005
    ....
  30. pmc Involvement of vacuolar sequestration and active transport in tolerance of Saccharomyces cerevisiae to hop iso-alpha-acids
    Lucie A Hazelwood
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Appl Environ Microbiol 76:318-28. 2010
    The hop plant, Humulus lupulus L., has an exceptionally high content of secondary metabolites, the hop alpha-acids, which possess a range of beneficial properties, including antiseptic action...
  31. ncbi Effect of K-diformate in starter diets on acidity, microbiota, and the amount of organic acids in the digestive tract of piglets, and on gastric alterations
    N Canibe
    Danish Institute of Agricultural Sciences, Department of Animal Nutrition and Physiology, Research Centre Foulum, Tjele
    J Anim Sci 79:2123-33. 2001
    ..was to study the effect of K-diformate on the intraluminal pH, microbial composition in digesta and feces, organic acids along the digestive tract, and alterations of the gastric epithelium of pigs...
  32. ncbi Determination of organic acids, sugars, diacetyl, and acetoin in cheese by high-performance liquid chromatography
    G Zeppa
    Dipartimento Valorizzazione e Protezione Risorse Agroforestali Settore Microbiologia e Industrie agrarie, Universita di Torino, Via L da Vinci 44, 10095, Grugliasco, Torino, Italy
    J Agric Food Chem 49:2722-6. 2001
    Sugars (lactose, glucose, and galactose), nonvolatile acids (citric, orotic, piruvic, lactic, ossalic, and hippuric), some free fatty acids (formic, acetic, propionic, butyric, isobutyric, valeric, and isovaleric), diacetyl, and acetoin ..
  33. ncbi Hydrophobic core variant ubiquitin forms a molten globule conformation at acidic pH
    Soon Ho Park
    Department of Dentistry, College of Dentistry, Kangnung National University, Gangneung 210 702, Korea
    J Biochem Mol Biol 37:676-83. 2004
    ..This observation suggests that the equilibrium molten globule state of hydrophobic core variant ubiquitin is an on-pathway folding intermediate...
  34. doi Sea urchin fertilization in a warm, acidified and high pCO2 ocean across a range of sperm densities
    Maria Byrne
    Schools of Medical and Biological Sciences, University of Sydney, NSW 2006, Australia
    Mar Environ Res 69:234-9. 2010
    ..It is important to identify where vulnerabilities lie across life histories and our results indicate that sea urchin fertilization is robust to climate change stressors. However, developmental stages may be vulnerable to ocean change...
  35. ncbi Role of organic acids in enhancing the desorption and uptake of weathered p,p'-DDE by Cucurbita pepo
    Jason C White
    Department of Soil and Water, The Connecticut Agricultural Experiment Station, 123 Huntington Street, New Haven, CT 06504, USA
    Environ Pollut 124:71-80. 2003
    Experiments were conducted to assess the effect of seven organic acids [succinic, tartaric, malic, malonic, oxalic, citric, ethylene-diaminetetraacetic (EDTA)] over a concentration range of two orders of magnitude (0.001-0...
  36. doi Modulation of organic acids and sugar content in tomato fruits by an abscisic acid-regulated transcription factor
    Adriana Bastías
    Instituto de Biologia Vegetal y Biotecnologia, Universidad de Talca, Talca, Chile
    Physiol Plant 141:215-26. 2011
    ..These results suggest that an AREB-mediated ABA signal affects the metabolism of these compounds during the fruit developmental program...
  37. pmc Primordial soup or vinaigrette: did the RNA world evolve at acidic pH?
    Harold S Bernhardt
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Biol Direct 7:4. 2012
    ..As the Hadean Eon progressed, the ocean pH is inferred to have gradually risen to near neutral as atmospheric CO(2) levels decreased...
  38. ncbi Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells
    Rhonda F Souza
    Department of Medicine, Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 287:G743-8. 2004
    ..These findings suggest potential mechanisms whereby acid reflux might promote carcinogenesis in Barrett's esophagus...
  39. ncbi Thermochemical studies on the quantity-antibacterial effect relationship of four organic acids from Radix Isatidis on Escherichia coli growth
    Weijun Kong
    Institute of Chinese Materia Medica, 302 Hospital of People s Liberation Army, Beijing, China
    Biol Pharm Bull 31:1301-5. 2008
    In this report, we have investigated the inhibitory action of four organic acids from Radix Isatidis on Escherichia coli growth was investigated at 37 degrees C by using a microcalorimeter...
  40. pmc Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions
    Richard M LoPachin
    Department of Anesthesiology, Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467, United States
    Chem Res Toxicol 25:239-51. 2012
    ..Over the course of the past few decades, the theory of Hard and Soft, Acids and Bases (HSAB) has proven to be a useful tool in predicting the outcome of such reactions...
  41. pmc Impact of ocean warming and ocean acidification on larval development and calcification in the sea urchin Tripneustes gratilla
    Hannah Sheppard Brennand
    School of Medical Sciences, University of Sydney, Sydney, New South Whales, Australia
    PLoS ONE 5:e11372. 2010
    ..However, this may be buffered by enhanced growth and metabolism due to warming...
  42. doi MCCE analysis of the pKas of introduced buried acids and bases in staphylococcal nuclease
    M R Gunner
    Department of Physics, City College of New York, New York, New York 10031, USA
    Proteins 79:3306-19. 2011
    The pK(a)s of 96 acids and bases introduced into buried sites in the staphylococcal nuclease protein (SNase) were calculated using the multiconformation continuum electrostatics (MCCE) program and the results compared with experimental ..
  43. pmc In situ proteo-metabolomics reveals metabolite secretion by the acid mine drainage bio-indicator, Euglena mutabilis
    David Halter
    UMR7156 Université de Strasbourg CNRS, Genetique Moleculaire, Génomique et Microbiologie, Département Micro organismes, Génomes, Environnement, Strasbourg, France
    ISME J 6:1391-402. 2012
    ..Our results revealed that the secreted metabolites are represented by a large number of amino acids, polyamine compounds, urea and some sugars but no fatty acids, suggesting a selective organic matter contribution ..
  44. doi Exploring tryptophan dynamics in acid-induced molten globule state of bovine alpha-lactalbumin: a wavelength-selective fluorescence approach
    Devaki A Kelkar
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad, India
    Eur Biophys J 39:1453-63. 2010
    ..These results could provide vital insight into the role of tryptophans in the function of BLA in its molten globule state in particular, and other partially ordered proteins in general...
  45. doi Acid-base balance and weight gain: are there crucial links via protein and organic acids in understanding obesity?
    Shoma Berkemeyer
    Ruhr Universitat Bochum, Klinik für Altersmedizin und Frührehabilitation, Studienbüro, Room 23, Widumerstr 8, 44627 Herne, Germany
    Med Hypotheses 73:347-56. 2009
    ..gain, in particular adipose tissue gain, with increased hydrogen ion concentration, taking protein and organic acids as important caveats in this discussion...
  46. doi Cyclopropane fatty acids improve Escherichia coli survival in acidified minimal media by reducing membrane permeability to H+ and enhanced ability to extrude H+
    Lana Shabala
    Food Safety Centre, Tasmanian Institute of Agricultural Research, School of Agricultural Science, University of Tasmania, Private Bag 54, Hobart, TAS 7001, Australia
    Res Microbiol 159:458-61. 2008
    The physiological role of cyclopropane fatty acids (CFAs) in acid stress resistance was studied by in situ microelectrode H+ flux measurements of Escherichia coli Frag1 and its isogenic CFA-deficient mutant JBM 1...
  47. ncbi Proteome phenotyping of acid stress-resistant mutants of Lactococcus lactis MG1363
    Aurélie Budin-Verneuil
    Laboratoire Microbiologie de l Environnement, EA956 USC INRA 2017, Universite de Caen, Caen, France
    Proteomics 7:2038-46. 2007
    ....
  48. pmc Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis
    Aaron Goldman
    Department of Cell Biology and Anatomy, Univ of Arizona, 1501 N Campbell Ave P O Box 245044, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 300:G292-302. 2011
    ..cells, which can differentiate to columnar cells as a result of repeated exposure to gastric acid and bile acids, two components of refluxate implicated in BE pathology...
  49. ncbi Organic acids, sugars, and L-tryptophane in exudates of vegetables growing on stonewool and their effects on activities of rhizosphere bacteria
    Faina Kamilova
    Leiden University, Institute of Biology, Clusius Laboratory, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Mol Plant Microbe Interact 19:250-6. 2006
    ..To this end, the composition of the organic acids and sugars, as well that of tryptophane, of axenically collected exudates of seed, seedlings, and roots of tomato, ..
  50. doi Biodegradation of polyfluoroalkyl phosphates as a source of perfluorinated acids to the environment
    Holly Lee
    Department of Chemistry, University of Toronto, Toronto, Ontario, Canada
    Environ Sci Technol 44:3305-10. 2010
    ..This observation, together with the diPAP concentrations observed in WWTP sludge, suggest PAPs-containing commercial products may be a significant contributor to the increased PFCA mass flows observed in WWTP effluents...
  51. doi The role of transient receptor potential vanilloid-1 on neural responses to acids by the chorda tympani, glossopharyngeal and superior laryngeal nerves in mice
    T Arai
    Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Neuroscience 165:1476-89. 2010
    ..To test this possibility, we recorded electrophysiological responses to several acids (acetic acid, citric acid and HCl) and other taste stimuli from the mouse chorda tympani, glossopharyngeal and ..
  52. pmc ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95
    Xiang ming Zha
    Howard Hughes Medical Institute, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 29:8438-46. 2009
    ..These results indicate that ASIC2 facilitates ASIC1a localization and function in dendritic spines and suggest that the two subunits work in concert to regulate neuronal function...
  53. ncbi Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss)
    Jonathan W Martin
    University of Guelph, Department of Environmental Biology, Bovey Building, Guelph, Ontario N1G 2W1, Canada
    Environ Toxicol Chem 22:196-204. 2003
    ..system to determine compound-specific tissue distribution and bioconcentration parameters for perfluorinated acids (PFAs). In general, PFAs accumulated to the greatest extent in blood > kidney > liver > gall bladder...
  54. pmc A glutamate-dependent acid resistance gene in Escherichia coli
    B M Hersh
    Department of Biology, Kenyon College, Gambier, Ohio 43022, USA
    J Bacteriol 178:3978-81. 1996
    ..coli from cytoplasmic acidification. The role of the glutamate cycle is particularly important for cultures grown at neutral pH before exposure to extreme acid...
  55. pmc Hydrogenase-3 contributes to anaerobic acid resistance of Escherichia coli
    Ken Noguchi
    Department of Biology, Kenyon College, Gambier, Ohio, United States of America
    PLoS ONE 5:e10132. 2010
    ..Most acid resistance mechanisms have been defined using aerobic cultures, but the use of anaerobic cultures will reveal novel acid resistance mechanisms...
  56. ncbi The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice
    M P Price
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Neuron 32:1071-83. 2001
    ..Moreover, in different cellular contexts, DRASIC may respond to mechanical stimuli or to low pH to mediate normal touch and pain sensation...
  57. ncbi Dietary potential renal acid load and renal net acid excretion in healthy, free-living children and adolescents
    Thomas Remer
    Department of Nutrition and Health, the Research Institute of Child Nutrition, Dortmund, Germany
    Am J Clin Nutr 77:1255-60. 2003
    ..Experimental studies in adults showed that renal net acid excretion (NAE) can be reliably estimated from the composition of diets...
  58. pmc Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines
    Xiang ming Zha
    Howard Hughes Medical Institute, and Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 103:16556-61. 2006
    ..The results provide insight into how protons influence brain function and how they may contribute to pathophysiology...
  59. doi Microbial production of organic acids: expanding the markets
    Michael Sauer
    School of Bioengineering, FH Campus Wien University of Applied Sciences, Muthgasse 18, 1190 Wien, Austria
    Trends Biotechnol 26:100-8. 2008
    Microbial production of organic acids is a promising approach for obtaining building-block chemicals from renewable carbon sources...
  60. pmc Control of acid resistance in Escherichia coli
    M P Castanie-Cornet
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    J Bacteriol 181:3525-35. 1999
    ..Neither gad gene required the presence of volatile fatty acids for induction...
  61. ncbi Membrane cyclopropane fatty acid content is a major factor in acid resistance of Escherichia coli
    Y Y Chang
    Department of Microbiology, University of Illinois, Urbana 61801, USA
    Mol Microbiol 33:249-59. 1999
    ..Much, but not all, of this variability can be explained by the partially or totally defective RpoS alleles carried by many strains...
  62. doi Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds
    Marjan Van Cleemput
    Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Gent, Belgium
    J Nat Prod 72:1220-30. 2009
    Hop acids, a family of bitter compounds derived from the hop plant (Humulus lupulus), have been reported to exert a wide range of effects, both in vitro and in vivo...
  63. ncbi Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors
    Anthony Sebastian
    Department of Medicine and the General Clinical Research Center, University of California, San Francisco, California 94143, USA
    Am J Clin Nutr 76:1308-16. 2002
    ..Natural selection has had < 1% of hominid evolutionary time to eliminate the inevitable maladaptations consequent to the profound transformation of the human diet resulting from the inventions of agriculture and animal husbandry...
  64. doi Climate change and ocean acidification effects on seagrasses and marine macroalgae
    Marguerite Koch
    Aquatic Plant Ecology Laboratory, Department of Biological Sciences, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA
    Glob Chang Biol 19:103-32. 2013
    ..Calcareous macroalgae are highly vulnerable to OA, and it is likely that fleshy macroalgae will dominate in a higher CO2 ocean; therefore, it is critical to elucidate the research gaps identified in this review...
  65. ncbi Internal pH crisis, lysine decarboxylase and the acid tolerance response of Salmonella typhimurium
    Y K Park
    Department of Biology, Korea University, Soeul, Korea
    Mol Microbiol 20:605-11. 1996
    ..The results suggest that S. typhimurium has a variety of means of fulfilling the pH homeostasis requirement of the ATR in the form of inducible amino acid decarboxylases...
  66. ncbi The discovery and characterization of a proton-gated sodium current in rat retinal ganglion cells
    Sarah Lilley
    Neural Injury and Repair Group, Centre for Neuroscience Research, King s College London, Guy s Campus, London, SE1 1UL, United Kingdom
    J Neurosci 24:1013-22. 2004
    ..The presence of a proton-gated current in the neural retina suggests that ASICs may have a more diverse role in the CNS...
  67. ncbi DRASIC contributes to pH-gated currents in large dorsal root ganglion sensory neurons by forming heteromultimeric channels
    Jinghui Xie
    Howard Hughes Medical Institute, Departments of Internal Medicine, and Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Neurophysiol 87:2835-43. 2002
    ..The results also suggest that related acid-activated DEG/ENaC channel subunits contribute with DRASIC to form heteromultimeric acid-activated channels...
  68. doi Calcium- and polyphosphate-containing acidocalcisomes in chicken egg yolk
    Isabela B Ramos
    Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Biol Cell 102:421-34. 2010
    ....
  69. doi Solubilization of protein aggregates by the acid stress chaperones HdeA and HdeB
    Abderrahim Malki
    Stress Molecules Laboratory, Institut Jacques Monod, Universite Paris 7, 2 place Jussieu, 75005 Paris, France
    J Biol Chem 283:13679-87. 2008
    ....
  70. ncbi Liposomal delivery of hydrophobic weak acids: enhancement of drug retention using a high intraliposomal pH
    Vijay Joguparthi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA
    J Pharm Sci 97:433-54. 2008
    ..Simulations were conducted to explore the role of membrane binding, intravesicular pH, and carbonate buffer concentration in successful utilization of the pH gradient strategy for hydrophobic weak acids.
  71. doi Effects of oxidation of lysozyme by hypohalous acids and haloamines on enzymatic activity and aggregation
    Maicon S Petronio
    Departamento de Quimica, Facultade de Ciencias, UNESP Universidade Estadual Paulista, Bauru, SP, Brazil
    Biochim Biophys Acta 1824:1090-6. 2012
    ..Moreover, the oxidation of HEL by just a small excess of hypohalous acids, a condition that could be found in inflammatory sites, may represent a new pathway for initiation of aggregation.
  72. doi External concentration of organic acid anions and pH: key independent variables for studying how organic acids inhibit growth of bacteria in mildly acidic foods
    C E Carpenter
    Dept of Nutrition and Food Sciences, Utah State Univ, Logan, 84322, USA
    J Food Sci 74:R12-5. 2009
    Although the mechanisms by which organic acids inhibit growth of bacteria in mildly acidic foods are not fully understood, it is clear that intracellular accumulation of anions is a primary contributor to inhibition of bacterial growth...
  73. pmc The effect of the combination of acids and tannin in diet on the performance and selected biochemical, haematological and antioxidant enzyme parameters in grower pigs
    Marina Stukelj
    University of Ljubljana, Veterinary Faculty, Clinic for Small Animal Medicine and Surgery, Gerbiceva 60, 1000 Ljubljana, Slovenia
    Acta Vet Scand 52:19. 2010
    ..chemotherapeutics as growth promoters have stimulated the swine industry to look for alternatives such as organic acids, botanicals, probiotics and tannin...
  74. doi Transport of hop bitter acids across intestinal Caco-2 cell monolayers
    Ko Cattoor
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, UGent Ghent University, Ghent, Belgium
    J Agric Food Chem 58:4132-40. 2010
    Several health-beneficial properties of hop bitter acids have been reported (inhibition of bone resorption and anticarcinogenic and anti-inflammatory activities); however, scientific data on the bioavailability of these compounds are ..
  75. pmc Insights into the diversity of eukaryotes in acid mine drainage biofilm communities
    Brett J Baker
    Department of Earth and Planetary Sciences, University of California, Berkeley, California 94720, USA
    Appl Environ Microbiol 75:2192-9. 2009
    ....
  76. doi Impact of near-future ocean acidification on echinoderms
    S Dupont
    Department of Marine Ecology, The Sven Lovén Centre for Marine Sciences, University of Gothenburg, Kristineberg, Sweden
    Ecotoxicology 19:449-62. 2010
    ..g. pH, temperature, toxicants) and organism health. However, available data allow us to conclude that near-future OA will have negative impact on echinoderm taxa with likely significant consequences at the ecosystem level...
  77. doi Synergetic stress of acids and ammonium on the shift in the methanogenic pathways during thermophilic anaerobic digestion of organics
    Fan Lu
    Institute of Waste Treatment and Reclamation, Tongji University, Shanghai 200092, China
    Water Res 47:2297-306. 2013
    Combined effects of acids and ammonium on functional pathway and microbial structure during organics methanization were investigated by stable isotopic method and quantitative PCR...
  78. ncbi Phenolic compounds, organic acids profiles and antioxidative properties of beefsteak fungus (Fistulina hepatica)
    Barbara Ribeiro
    REQUIMTE Servico de Farmacognosia, Faculdade de Farmacia, Universidade do Porto, R Anibal Cunha, 164, 4050 047 Porto, Portugal
    Food Chem Toxicol 45:1805-13. 2007
    The phenolic compounds and the organic acids composition of the edible beefsteak fungus Fistulina hepatica was determined by HPLC/DAD and HPLC/UV, respectively...
  79. doi Identification of organic acids in Cichorium intybus inhibiting virulence-related properties of oral pathogenic bacteria
    Adele Papetti
    Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
    Food Chem 138:1706-12. 2013
    ..The extract contained a number of components, including oxalic, succinic, shikimic and quinic acids, which interfere with the growth and virulence traits (i.e...
  80. doi Effect of dietary acids on growth performance of nursery pigs: a cooperative study
    T M Che
    North Central Coordinating Committee on Swine Nutrition, Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Anim Sci 90:4408-13. 2012
    ..pigs (20 replicate pens of 4 to 8 pigs per pen) was conducted at 8 experiment stations to determine the effects of acids in nursery pig diets and their inclusion amounts on growth performance using diets and weaning ages typical of ..
  81. doi Induction of an oxalate decarboxylase in the filamentous fungus Trametes versicolor by addition of inorganic acids
    Cui xia Zhu
    Donghua University, Shanghai, China
    Appl Biochem Biotechnol 160:655-64. 2010
    ..OxDC was induced by addition of inorganic acids including hydrochloric acid, sulfuric acid, and phosphoric acid to culture media...
  82. ncbi Time- and concentration-dependent metabolic and genomic responses to exposure to resin acids in brown trout (Salmo trutta m. lacustris)
    Päivi S Meriläinen
    Department of Biological and Environmental Sciences, University of Jyvaskyla, Finland
    Environ Toxicol Chem 26:1827-35. 2007
    The presence of metabolically conjugated resin acids (RAs) in the bile is considered to be a sensitive indicator for exposure of fish to pulp and paper industry effluents; however, to our knowledge, no comprehensive kinetic study of this ..
  83. doi Efficacy of organic acids, bacteriocins, and the lactoperoxidase system in inhibiting the growth of Cronobacter spp. in rehydrated infant formula
    Satoru Oshima
    Food Technology Research Institute, Division of Research and Development, Meiji Co, Ltd, 540 Naruda, Odawara, Kanagawa, 250 0862 Japan
    J Food Prot 75:1734-42. 2012
    Thirty-three antimicrobial agents, including antimicrobial peptides (nisin, lacticin 3147, isracidin), organic acids, emulsifiers (organic acid esters), glycine, lysozyme, tocopherol, EDTA, milk fat globule membrane, and the ..
  84. ncbi Lewis base activation of Lewis acids: development of a Lewis base catalyzed selenolactonization
    Scott E Denmark
    Roger Adams Laboratory, Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    Org Lett 9:3801-4. 2007
    The concept of Lewis base activation of Lewis acids has been applied to the selenolactonization reaction...
  85. doi Domino rhodium/palladium-catalyzed dehydrogenation reactions of alcohols to acids by hydrogen transfer to inactivated alkenes
    Monica Trincado
    Department of Chemistry and Applied Biosciences, ETH Honggerberg, 8093 Zurich, Switzerland
    Chemistry 16:2751-7. 2010
    ..overall process represents a mild and direct method for the synthesis of aromatic and heteroaromatic carboxylic acids for which inactivated olefins can be used as hydrogen acceptors...
  86. doi Superlubricity achieved with mixtures of polyhydroxy alcohols and acids
    Jinjin Li
    State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, People s Republic of China
    Langmuir 29:5239-45. 2013
    ..Li , J. J.; Zhang, C. H.; Ma, L. R.; Liu, Y. H.; Luo, J. B. Superlubricity achieved with mixtures of acids and glycerol. Langmuir 2013, 29, 271-275)...
  87. doi Near future ocean acidification increases growth rate of the lecithotrophic larvae and juveniles of the sea star Crossaster papposus
    Sam Dupont
    Department of Marine Ecology, University of Gothenburg, Sven Lovén Centre for Marine Sciences, Kristineberg, Sweden
    J Exp Zool B Mol Dev Evol 314:382-9. 2010
    ....
  88. doi Proteome changes in the initial bacterial colonist during ecological succession in an acid mine drainage biofilm community
    Ryan S Mueller
    University of California, Berkeley, California 94720, USA
    Environ Microbiol 13:2279-92. 2011
    ..This population also represses translation and synthesizes more complex carbohydrates and amino acids in mature biofilms...
  89. pmc Cyclopropanation of membrane unsaturated fatty acids is not essential to the acid stress response of Lactococcus lactis subsp. cremoris
    Thi Mai Huong To
    Laboratoire Recherche en Vigne et Vin EA 4149, Universite de Bourgogne, IUVV, 1 Rue Claude Ladrey, Campus Universitaire Montmuzard, BP27877, F 21078 Dijon, France
    Appl Environ Microbiol 77:3327-34. 2011
    Cyclopropane fatty acids (CFAs) are synthetized in situ by the transfer of a methylene group from S-adenosyl-L-methionine to a double bond of unsaturated fatty acid chains of membrane phospholipids...
  90. ncbi Dietary accumulation of perfluorinated acids in juvenile rainbow trout (Oncorhynchus mykiss)
    Jonathan W Martin
    University of Guelph, Department of Environmental Biology, Bovey Building, Guelph, Ontario N1G 2W1, Canada
    Environ Toxicol Chem 22:189-95. 2003
    Perfluorinated acids (PFAs) recently have emerged as persistent global contaminants after their detection in wildlife and humans from various geographic locations...
  91. pmc Genotypic and physiological characterization of Saccharomyces boulardii, the probiotic strain of Saccharomyces cerevisiae
    Laura Edwards-Ingram
    Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, UK
    Appl Environ Microbiol 73:2458-67. 2007
    ..The contributions of the different genomic and phenotypic features of S. boulardii to its probiotic nature are discussed...
  92. ncbi Interaction of alpha-and beta-oligoarginine-acids and amides with anionic lipid vesicles: a mechanistic and thermodynamic study
    Thomas Hitz
    Department of Materials, Institute of Polymers, ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Biochemistry 45:5817-29. 2006
    The interaction of alpha- and beta-oligoarginine amides and acids and of alpha-polyarginine with anionic lipid vesicles was studied. The beta-oligoarginines used were beta3-homologues of the alpha-oligoarginines...
  93. pmc Modulation of rat chorda tympani NaCl responses and intracellular Na+ activity in polarized taste receptor cells by pH
    Vijay Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    J Gen Physiol 120:793-815. 2002
    ..We conclude that TRC pH(i) regulates Na(+)-influx through amiloride-sensitive apical ENaCs and hence modulates NaCl CT responses in acid/salt mixtures...
  94. doi Heteropoly acids as efficient acid catalysts in the one-step conversion of cellulose to sugar alcohols
    Regina Palkovits
    RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany
    Chem Commun (Camb) 47:576-8. 2011
    ..Thereby, heteropoly acids together with supported ruthenium catalysts show not only high activity but also remarkable selectivity to sugar ..
  95. ncbi Enantioselective photocycloaddition mediated by chiral Brønsted acids: asymmetric synthesis of the rocaglamides
    Baudouin Gerard
    Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, Boston, Massachusetts 02215, USA
    J Am Chem Soc 128:7754-5. 2006
    ..The approach involves enantioselective [3 + 2] photocycloaddition promoted by chiral Brønsted acids (TADDOLs) to afford an aglain precursor followed by a ketol shift/reduction sequence to the rocaglate core.
  96. ncbi Proton-gated cation channels--neuronal acid sensors in the central and peripheral nervous system
    R Waldmann
    , Sophia-Antipolis, Valbonne, France
    Adv Exp Med Biol 502:293-304. 2001
    ....
  97. ncbi Solid acids for green chemistry
    James H Clark
    Green Chemistry Group, Clean Technology Centre, University of York, York YO10 5DD, England
    Acc Chem Res 35:791-7. 2002
    Solid acids and especially those based on micelle-templated silicas and other mesoporous high surface area support materials are beginning to play a significant role in the greening of fine and specialty chemicals manufacturing processes...
  98. doi Noninvasive urinary organic acids test to assess biochemical and nutritional individuality in autistic children
    Joanna Kałużna-Czaplińska
    Institute of General and Ecological Chemistry, Department of Chemistry, Technical University of Lodz, 116 Zeromskiego Str, 90 924 Lodz, Poland
    Clin Biochem 44:686-91. 2011
    ..The aim of this study was to find out potential differences between the levels of organic acids in the urine of autistic and non-autistic children.
  99. pmc Modification of the technical properties of Lactobacillus johnsonii NCC 533 by supplementing the growth medium with unsaturated fatty acids
    J A Muller
    Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, County Cork, Ireland
    Appl Environ Microbiol 77:6889-98. 2011
    The aim of this study was to investigate the influence of supplementing growth medium with unsaturated fatty acids on the technical properties of the probiotic strain Lactobacillus johnsonii NCC 533, such as heat and acid tolerance, and ..
  100. ncbi Growth of Campylobacter in media supplemented with organic acids
    Arthur Hinton
    Poultry Processing Unit, Agricultural Research Service, U S Department of Agriculture, 950 College Station Road, Russell Research Center, Athens, Georgia 30605, USA
    J Food Prot 69:34-8. 2006
    The growth of Campylobacter spp. in media supplemented with organic acids was examined...
  101. ncbi Occupational dental erosion from exposure to acids: a review
    Annette Wiegand
    Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, Plattenstrasse 11, Zurich, Switzerland
    Occup Med (Lond) 57:169-76. 2007
    ..Dental erosion is characterized as a disorder with a multifactorial aetiology including environmental acid exposure. The purpose of this article was to summarize and discuss the available information concerning occupational dental erosion...

Research Grants74

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  3. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..stimuli in the environment, including potentially damaging hot and cold temperatures, noxious chemicals such as acids, and sharp touch...
  4. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..of exogenous compounds such as drugs or toxins as well as endogenous compounds like hormones, bilirubin and bile acids and cholesterol. Liver-based metabolic disease can result from mutations in genes in these critical pathways...
  5. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..in starvation and diabetes because of induction of PDK2 and 4 by high levels of glucocorticoids and fatty acids and low levels of insulin...
  6. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ..H1R alleles differ by three amino acids in the third intracellular loop (H1RS: Pro263Val312Pro330;H1RR: Leu263Met312Ser330)...
  7. Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidney
    VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2013
    ..and 3) Fam20C phosphorylates FGF23 at Ser180 within an important regulatory motif and at 3 highly conserved amino acids within the C terminus that may affect binding of the hormone to its cognate receptor (preliminary data, ..
  8. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..Secondary outcomes will be plasma levels of catecholamines, free fatty acids, leptin and CRP. We will also collect daily data on weight, caloric intake, and energy expenditure...
  9. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..Tyrosine levels will be raised by administering tyrosine and lowered by giving a mixture of amino acids that limit entry of tyrosine into the brain...
  10. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..the changes in metabolic milieu (resting energy expenditure, glucose homeostasis, lipid profile, free fatty acids, serum total and free testosterone and IGF-1), and cytokines (c-reactive protein, tumor necrosis factor alpha and ..
  11. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..provided by applicant): The P450 epoxygenase pathway breaks down arachidonic acid into epoxyeicosatrienoic acids (EETs)...
  12. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..The therapeutic benefits of nitro-fatty acids (FA-NO2) and brain-derived neurotrophic factor- and nerve growth factor-antibodies (BDNF-AB and NGF-AB) will be ..
  13. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..The malignant brain tumor (MBT) repeat is a structural domain of ca. 100 amino acids and occurs in 11 human proteins which recognize mono- and dimethyl-lysine modifications of histones...
  14. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..Stearoyl-CoA desaturase- 1 (SCD1) is increased in obesity and catalyzes the conversion of saturated fatty acids (16:0 and 18:0) to mono- unsaturated fatty acids (16:1 and 18:1)...
  15. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..we will use DRB1*0401 and DRB1*0402 mice to determine the mechanism of protection to understand how 3 amino acids difference in both molecules lead to protection by the latter...
  16. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..if the suppression of cardiomyocyte autophagy by insulin signaling requires increased uptake of glucose or amino acids. Aim 4: will determine if insulin signaling suppresses cardiomyocyte autophagy by disrupting initiation of ..
  17. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    ..We propose to: 1. Determine the active site of C2GnT-M by X-ray crystallography and then confirm the amino acids involved in catalysis by site-directed mutagenesis followed by measurement of enzyme activities using core 1, core ..
  18. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..reduction of IKACh can be achieved through two mechanisms: (1) direct channel blockade involving specific amino acids in the cytoplasmic domain of the channel;and (2) internalization of Kir3.1/Kir3...
  19. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..reduction of IKACh can be achieved through two mechanisms: (1) direct channel blockade involving specific amino acids in the cytoplasmic domain of the channel;and (2) internalization of Kir3.1/Kir3...
  20. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..Omega 3 fatty acids are potent anti-inflammatory mole- cules and our studies show that these anti-inflammatory effects are largely ..
  21. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..The Na,K-ATPase is a heterodimeric integral membrane protein consisting of a catalytic a-subunit (~1000 amino acids) and a glycosylated [unreadable]-subunit (~300 amino acids)...
  22. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
    ..In the course of our studies on mechanisms by which fatty acids regulate gene expression, we discovered that the rate of RNA splicing is inhibited in liver and primary ..
  23. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2012
    ..have lower levels of docosaehexanoic acid - a long chain polyunsaturated (LC-PUFA) derivative of essential fatty acids - than female offspring, while no differences in LC-PUFAlevels exist between male and female offspring of lean ..
  24. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Public interest has resulted in increased consumption of omega-3 fatty acids as dietary supplements (derived mainly from fish-oil) based upon purported effects that include: reduction in ..
  25. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..of regulators, of which there are numerous members throughout the bacterial world, is inhibited by fatty acids present in bile...
  26. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..MPO also oxidizes aromatic amino acids such as tyrosine and tryptophan to generate cytotoxic tyrosyl and tryptophanyl radicals...
  27. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..We will also study the effects of point mutations of candidate amino acids to determine if specific aa in the PH and C-1 domains impact their important biological binding activities...
  28. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    ..This combination produces acids that penetrate and dissolves the tooth surfaces...
  29. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..Recent studies have shown that bile acids not only are physiological detergents that facilitate absorption, transport, distribution and disposal of steroids,..
  30. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..Regarding the mechanism of insulin resistance, the conventional hypothesis is that oxidation of long-chain fatty acids (LCFA) is impaired while availability is increased, and this results in the accumulation of intramyocellular lipid ..
  31. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..is characterized by an increase in the expression and activity of cPLA2 and iPLA , which liberate free fatty acids, including arachidonic acid, and lysophospholipids from membrane phospholipids...
  32. TARGETING THE MARCKS-FAMILY PROTEINS TO INHIBIT NEUTROPHIL MIGRATION
    Mary K Sheats; Fiscal Year: 2013
    ..MARCKS or MARCKSL1 inhibition will be accomplished using: cell permeant peptides identical to the 24 amino acids of the N-terminus of each protein, transgenic expression of a truncated fluorescently-tagged N-terminus MARCKS or ..
  33. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dietary polyunsaturated fatty acids (PUFA) are generally regarded as beneficial to human health...
  34. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..C5A corresponds to a small (18 amino acids) N-terminal region (aa 3-20) of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) (477 amino acids)...
  35. A quantitative proteomics approach to understand viral immune evasion strategies
    Michele E Hardy; Fiscal Year: 2010
    ..We will employ stable isotope labeling of amino acids in culture (SILAC) followed by high resolution chromatographic separation and tandem mass spectrometry...
  36. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..Research studies reveal that consumption of n-3 polyunsaturated fatty acids (PUFAs) found in fish oil holds promise for preventing and ameliorating chronic inflammatory diseases including ..
  37. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ..By carrying insertion of 15 amino acids at an antibody-binding site, the chimeric VLP reduces the reactivity to anti-HEV antibodies meanwhile retains the ..
  38. Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid Metabolism
    HUIPING ROSE ZHOU; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bile acids are crucial for lipid homeostasis in the liver. During the last decade, researchers have discovered that bile acids not only act as detergents, but also as important signaling molecules...
  39. Role of Peroxidasin in Glomerular Matrix Homeostasis
    Gautam Bhave; Fiscal Year: 2013
    ..H2O2 to highly reactive hypobromous (HOBr) and hypochlorous (HOCl) acid, collectively denoted as hypohalous acids (HOX)...
  40. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2013
    ..have lower levels of docosaehexanoic acid - a long chain polyunsaturated (LC-PUFA) derivative of essential fatty acids - than female offspring, while no differences in LC-PUFA levels exist between male and female offspring of lean ..
  41. Development of Vaccines against Clostridium difficile Infection
    SAUL R TZIPORI; Fiscal Year: 2013
    ..cTxAB has a small deletion (97 amino acids) in transmembrane domain rendering it non-toxic...
  42. Roles for microRNA-122 in hepatitis C virus RNA amplification
    Peter Sarnow; Fiscal Year: 2013
    ..in the viral life cycle and in cholesterol biosynthesis using a novel class of antisense molecules, locked nucleic acids (LNAs) that can easily be delivered to the liver in animals where it sequesters miR-122 in an inactive small ..
  43. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..of energy in the form of TAG and the mobilization of this stored energy leading to the release of free fatty acids, the process known as lipolysis...
  44. The genetics and pathophysiology of impaired Wnt signaling in metabolic syndrome
    Arya Mani; Fiscal Year: 2012
    ..we have identified the disease causing mutations that substitute evolutionarily highly conservative amino acids in the LDL receptor like protein (LRP6), a co-receptor in the Wnt signaling pathway...
  45. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..Monthly measurements of circulating lipids, hormones and bile acids will be taken...
  46. Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic Acids
    TIMOTHY L SITA; Fiscal Year: 2013
    ..interfering RNA (siRNA) duplexes densely conjugated to the surface of gold nanoparticles (MGMTi-Spherical Nucleic Acids (SNAs))...
  47. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..Stearoyl Coenzyme A Desaturase-1 (SCD-1) synthesizes monounsaturated fatty acids (MUFA;C16:1 and C18:1) from dietary or de novo saturated fatty acids (SFA;C16:0 and C18:0)...
  48. Genetics of the Neuromuscular Junction: Mechanisms and Disease Models
    Robert W Burgess; Fiscal Year: 2013
    ..These enzymes are well characterized for their function in charging amino acids onto their cognate tRNAs for translation...
  49. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..Phospholipases A generate fatty acids and receptor-active lysophospholipids...
  50. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    ..Both n-3 fatty acids (FA) and calorie restriction (CR) are anti-inflammatory and anti-oxidative...
  51. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond F Novak; Fiscal Year: 2010
    ..it increases oxidative stress, catalyzes the metabolism of carcinogens, therapeutic agents, eicosanoids, and fatty acids, reflects an altered phenotype, and is a biomarker of progressive hepatic disease development with loss of CYP2E1 ..
  52. Regulation of K-Ras by a Farnesyl-electrostatic Switch
    MARK REID PHILIPS; Fiscal Year: 2013
    ..We found that phosphorylation of K-Ras at serine 181 partially neutralized the adjacent polybasic stretch of amino acids and thereby activated a farnesyl-electrostatic switch that resulted in release of K-Ras from the plasma membrane ..
  53. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
  54. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..and dendritic cells (DC) in mucosal tissues express receptors that are triggered by viral proteins and nucleic acids, leading to the secretion of anti-viral factors that destroy the invading pathogen...
  55. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..with increased hepatic production of triglyceride-rich lipoproteins (TGRLs) and increased levels of fatty acids (FAs, saturated FAs in particular). Current data suggest that these changes activate leukocytes in blood and AT...
  56. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2013
    ..FABPs bind a variety of unesterified fatty acids and other lipid second messengers and mediate their intracellular metabolism...
  57. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Cholesterol and fatty acids play critical functional roles in many physiological processes in metazoans, such as modulating membrane fluidity, ..
  58. Role of GDNF in the regulation of hepatic steatosis
    SHANTHI K SRINIVASAN; Fiscal Year: 2013
    ..activated receptor coactivator -1a (PGC-1a) in hepatocytes, resulting in up regulation of enzymes related to fatty acids beta-oxidation and mitochondrial biogenesis...
  59. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..f oxygen to produce reactive oxygen species that damage biological molecules such as proteins, lipids and nucleic acids and subsequently cause cell death...
  60. DNA Repair Deficiency Associated with Obesity and the Metabolic Syndrome
    R Stephen Lloyd; Fiscal Year: 2013
    ..Although it is well established that lipids, proteins and nucleic acids are critical cellular targets for endogenously and exogenously produced ROS, until recently, deficiencies in ..
  61. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..Aim 3: To quantify the biochemical reduction of de novo synthesis of triglycerides and enhanced oxidation of fatty acids and VLDL secretion by GLP-1...
  62. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..Affinity maturation, in combination with targeted in vitro mutagenesis of specific amino acids known to modify specificity of the binding site for digoxin, will yield multipe clones...
  63. MOLECULAR MECHANISMS OF OXIDATION OF LDL
    Sampath Parthasarathy; Fiscal Year: 1999
    ..These will be incubated with various amine-containing compounds including soluble proteins (e.g., BSA), polyamino acids, amino acids, apolipoproteins and alkylamines. Some incubations will be conducted in the presence of antioxidants...
  64. Identification of biomarkers of fatty acid intake
    Hannia Campos; Fiscal Year: 2002
    Fatty acids in the blood and more recently in adipose tissue are widely used as biomarkers of fatty acid intake in individuals and populations...
  65. Delivery of biologically active nucleic acids to epidermal cells
    ROGER L contact KASPAR; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The broad potential for using nucleic acids to treat human disease has not been realized...
  66. Molecular Modulation of Catalytic Sites of Escherichia coli F1Fo ATP Synthase
    Zulfiqar Ahmad; Fiscal Year: 2009
    ..function of this nanomotor, it is paramount to identify and characterize the role of phosphate binding amino acids and their interactions. So far, six amino acids from the catalytic sites have been characterized...
  67. REGULATION OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 1999
    The conversion of cholesterol to bile acids in the liver is the major pathway for the catabolism of cholesterol and plays an important role in the maintenance of cholesterol homeostasis...
  68. DIETARY LIPIDS--EFFECTS ON LIPID-LIPOPROTEIN METABOLISM
    D Illingworth; Fiscal Year: 1991
    ..The influence of diets in which monounsaturated fatty acids represent the main source of fat will be investigated in terms of their lipid lowering effects compared to similar ..
  69. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2004
    BACKGROUND: Obese hypertensives have elevated plasma non-esterified fatty acids (NEFAs) including oleic acid. Oleic acid induces a PKC-dependent increase of reactive oxygen species in vascular smooth muscle cells...
  70. INTRACELLULAR TRANSPORT OF AMPHIPATHS
    Bruce Luxon; Fiscal Year: 2000
    ..to elucidate the mechanism underlying the cytoplasmic transport of amphipathic molecules like long-chain fatty acids and bile acids...
  71. Development of Novel Fluorinated Amino Acids
    Mark Goodman; Fiscal Year: 2004
    ..Our approach will focus on the development of [18F]cyclobutyl and [18F]branched nonmetabolized amino acids that move across tumor capillaries by carrier-mediated facilitated transport involving either the "L" large-..
  72. Surfaces designed for the quantification of long-chain fatty acids
    STEVEN MEYERS; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The detection of long chain fatty acids (e.g., quantity) in bodily fluids is an area that has not been fully explored...
  73. OMEGA-3 FATTY ACIDS & HEPATIC LIPID METABOLISM
    David Otto; Fiscal Year: 1990
    Interest in omega-3 fatty acids, high in fish oil, stems in part from studies indicating that populations with high fish consumption have lower mortality from CHD...
  74. DIETARY OMEGA-3 FATTY ACIDS, GENE EXPRESSION AND GROWTH
    William Heird; Fiscal Year: 2001
    Dietary omega3 fatty acids have been associated with higher rates of energy expenditure, lower rates of weight gain and/or lower rates of fat deposition in rodents as well as human infants and adults...