vitamin e

Summary

Summary: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.

Top Publications

  1. pmc Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    Arun J Sanyal
    Virginia Commonwealth University, Richmond, USA
    N Engl J Med 362:1675-85. 2010
  2. pmc Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    JAMA 301:39-51. 2009
  3. pmc Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Eric A Klein
    Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 306:1549-56. 2011
  4. ncbi Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    Goran Bjelakovic
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    JAMA 297:842-57. 2007
  5. ncbi Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality
    Edgar R Miller
    The Johns Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2223, USA
    Ann Intern Med 142:37-46. 2005
  6. pmc Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    Joel E Lavine
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University, New York, New York, USA
    JAMA 305:1659-68. 2011
  7. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
  8. pmc Vitamin E, antioxidant and nothing more
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 43:4-15. 2007
  9. ncbi The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals
    Serge Hercberg
    Institut National de la Sante et de la Recherche Medicale, Unité de Recherche Médicale INSERM Institut National de la Recherche Agronomique Conservatoire National des Ants et Métiers CNAM, Paris, France
    Arch Intern Med 164:2335-42. 2004
  10. ncbi Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis
    Julie Carrier
    Department of Medicine, University of Toronto, Ontario M5G 2C4, Canada
    J Nutr 132:3146-50. 2002

Detail Information

Publications399 found, 100 shown here

  1. pmc Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    Arun J Sanyal
    Virginia Commonwealth University, Richmond, USA
    N Engl J Med 362:1675-85. 2010
    ..Nonalcoholic steatohepatitis is a common liver disease that can progress to cirrhosis. Currently, there is no established treatment for this disease...
  2. pmc Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    JAMA 301:39-51. 2009
    Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer.
  3. pmc Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Eric A Klein
    Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 306:1549-56. 2011
    The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk of prostate cancer with either selenium or vitamin E supplements but a statistically nonsignificant increase in prostate cancer ..
  4. ncbi Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    Goran Bjelakovic
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    JAMA 297:842-57. 2007
    ..Antioxidant supplements are used for prevention of several diseases...
  5. ncbi Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality
    Edgar R Miller
    The Johns Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2223, USA
    Ann Intern Med 142:37-46. 2005
    Experimental models and observational studies suggest that vitamin E supplementation may prevent cardiovascular disease and cancer...
  6. pmc Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    Joel E Lavine
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University, New York, New York, USA
    JAMA 305:1659-68. 2011
    ..Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in US children and adolescents and can present with advanced fibrosis or nonalcoholic steatohepatitis (NASH). No treatment has been established...
  7. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
    Basic research and observational studies suggest vitamin E or vitamin C may reduce the risk of cardiovascular disease...
  8. pmc Vitamin E, antioxidant and nothing more
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 43:4-15. 2007
    All of the naturally occurring vitamin E forms, as well as those of synthetic all-rac-alpha-tocopherol, have relatively similar antioxidant properties, so why does the body prefer alpha-tocopherol as its unique form of vitamin E? We ..
  9. ncbi The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals
    Serge Hercberg
    Institut National de la Sante et de la Recherche Medicale, Unité de Recherche Médicale INSERM Institut National de la Recherche Agronomique Conservatoire National des Ants et Métiers CNAM, Paris, France
    Arch Intern Med 164:2335-42. 2004
    ..We tested the efficacy of nutritional doses of supplementation with a combination of antioxidant vitamins and minerals in reducing the incidence of cancer and ischemic cardiovascular disease in the general population...
  10. ncbi Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis
    Julie Carrier
    Department of Medicine, University of Toronto, Ontario M5G 2C4, Canada
    J Nutr 132:3146-50. 2002
    ..increases intestinal inflammation and oxidative stress and whether the addition of an antioxidant, vitamin E, would reduce this detrimental effect...
  11. pmc A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Intern Med 167:1610-8. 2007
    ..Few trials have examined interactions among antioxidants, and, to our knowledge, no previous trial has examined the individual effect of ascorbic acid (vitamin C) on CVD...
  12. ncbi Vitamin E decreases bone mass by stimulating osteoclast fusion
    Koji Fujita
    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    Nat Med 18:589-94. 2012
    ..Fat-soluble vitamins such as vitamin D are pivotal in maintaining skeletal integrity. However, the role of vitamin E in bone remodeling is unknown...
  13. ncbi Vitamin E exhibits bone anabolic actions in normal male rats
    Ahmad Nazrun Shuid
    Department of Pharmacology, Faculty of Medicine UKM, Universiti Kebangsaan Malaysia, Jln Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
    J Bone Miner Metab 28:149-56. 2010
    Recently, vitamin E has been found to promote the bone structure of nicotine-treated rats well above their baseline values, thus suggesting that vitamin E may have some anabolic action...
  14. ncbi The role of vitamin E and oxidative stress in diabetes complications
    Robert Pazdro
    Department of Foods and Nutrition, Purdue University, 700 West State Street, West Lafayette, IN 47907, USA
    Mech Ageing Dev 131:276-86. 2010
    ..We highlight results from studies performed to investigate the role of vitamin E in preventing diabetes-induced oxidative damage in cell culture, animal models, and human participants, and ..
  15. pmc Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
    Biochem Pharmacol 80:1613-31. 2010
    Initially discovered in 1938 as a "fertility factor," vitamin E now refers to eight different isoforms that belong to two categories, four saturated analogues (α, β, γ, and δ) called tocopherols and four unsaturated analogues ..
  16. pmc Tocotrienols: Vitamin E beyond tocopherols
    Chandan K Sen
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Life Sci 78:2088-98. 2006
    In nature, eight substances have been found to have vitamin E activity: alpha-, beta-, gamma- and delta-tocopherol; and alpha-, beta-, gamma- and delta-tocotrienol...
  17. ncbi Hematopoietic Recovery and Amelioration of Radiation-Induced Lethality by the Vitamin E Isoform δ-Tocotrienol
    Merriline M Satyamitra
    Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA
    Radiat Res 175:736-45. 2011
    Tocotrienol (DT3), a vitamin E isoform, is associated with strong antioxidant and immunomodulatory properties...
  18. pmc Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin
    Maaike Berbee
    University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Int J Radiat Oncol Biol Phys 79:884-91. 2011
    The vitamin E analog γ-tocotrienol (GT3) is a powerful radioprotector. GT3 reduces postradiation vascular peroxynitrite production, an effect dependent on inhibition of hydroxy-methylglutaryl-coenzyme A reductase...
  19. ncbi Vitamin E TPGS as a molecular biomaterial for drug delivery
    Zhiping Zhang
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Biomaterials 33:4889-906. 2012
    D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS, or simply TPGS) is a water-soluble derivative of natural Vitamin E, which is formed by esterification of Vitamin E succinate with polyethylene glycol (PEG)...
  20. pmc Selenium and vitamin E for prostate cancer: post-SELECT (Selenium and Vitamin E Cancer Prevention Trial) status
    Mark C Ledesma
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin, USA
    Mol Med 17:134-43. 2011
    Various formulations of selenium and vitamin E, both essential human dietary components, have been shown to possess a therapeutic and preventive effect against prostate cancer...
  21. pmc Normal adaptations to exercise despite protection against oxidative stress
    Kazuhiko Higashida
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 301:E779-84. 2011
    ..the antioxidant groups were given 750 mg·kg body wt(-1)·day(-1) vitamin C and 150 mg·kg body wt(-1)·day(-1) vitamin E. In rats euthanized immediately after exercise, plasma TBARs were elevated in the control rats but not in the ..
  22. ncbi Effects of dietary n-3 polyunsaturated fatty acids, breed and dietary vitamin E on the fatty acids of lamb muscle, liver and adipose tissue
    G Demirel
    Division of Farm Animal Science, School of Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU, UK
    Br J Nutr 91:551-65. 2004
    ..High levels of dietary vitamin E were associated with small decreases in the concentration of monounsaturated fatty acids and increases in PUFA...
  23. ncbi Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silent
    Jiri Neuzil
    Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith University Gold Coast Campus, Southport, Queensland, Australia
    Mol Pharmacol 71:1185-99. 2007
    ..b>Vitamin E (VE) analogs, epitomized by alpha-tocopheryl succinate, belong to the group of "mitocans" (mitochondrially ..
  24. ncbi Comparative effects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes
    Musalmah Mazlan
    Department of Biochemistry, Medical Faculty, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    J Neurol Sci 243:5-12. 2006
    ..Since the uptake of alpha-tocopherol and gamma-tocotrienol by astrocytes is similar, this may reflect the roles of these 2 vitamin E subfamilies in inhibiting apoptosis and stimulating proliferation in astrocytes.
  25. ncbi Vitamin E mediates cell signaling and regulation of gene expression
    Angelo Azzi
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Ann N Y Acad Sci 1031:86-95. 2004
    ..The antioxidant-responsive element (ARE) and the TGF-beta-responsive element (TGF-beta-RE) appear in some cases to be implicated as well...
  26. ncbi The HOPE study. Ramipril lowered cardiovascular risk, but vitamin E did not
    B J Hoogwerf
    Department of Endocrinology, Cleveland Clinic, OH 44195, USA
    Cleve Clin J Med 67:287-93. 2000
    ..On the other hand, vitamin E in the doses and duration studied (400 IU/day for 4.5 years) did not lower risk significantly.
  27. ncbi Emerging trade-offs - impact of photoprotectants (PsbS, xanthophylls, and vitamin E) on oxylipins as regulators of development and defense
    Barbara Demmig-Adams
    Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309 0334, USA
    New Phytol 197:720-9. 2013
    ..energy in the chloroplast and a mutant deficient in reactive oxygen detoxification via the antioxidant vitamin E (tocopherol)...
  28. ncbi A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    Elisabetta Bugianesi
    Department of Gastroenterology, University of Turin, Italy
    Am J Gastroenterol 100:1082-90. 2005
    ..We aimed to compare the usefulness of metformin versus prescriptive diet or vitamin E.
  29. ncbi Formulation of Docetaxel by folic acid-conjugated d-α-tocopheryl polyethylene glycol succinate 2000 (Vitamin E TPGS(2k)) micelles for targeted and synergistic chemotherapy
    Yu Mi
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 32:4058-66. 2011
    ....
  30. ncbi Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction
    J M Rapola
    National Public Health Institute, Helsinki, Finland
    Lancet 349:1715-20. 1997
    Epidemiological data suggest that the intake of antioxidants such as alpha-tocopherol (vitamin E) and beta-carotene has an inverse correlation with the incidence of coronary heart disease...
  31. ncbi First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway
    Kanjoormana A Manu
    Department of Pharmacology, Yong Loo Lin School of Medicine, Cancer Science Institute of Singapore, National University of Singapore
    Clin Cancer Res 18:2220-9. 2012
    ..Hence, novel agents that are safe and effective are urgently needed. Whether γ-tocotrienol can sensitize gastric cancer to capecitabine in vitro and in a xenograft mouse model was investigated...
  32. ncbi The European perspective on vitamin E: current knowledge and future research
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Am J Clin Nutr 76:703-16. 2002
    b>Vitamin E is indispensible for reproduction in female rats. In humans, vitamin E deficiency primarily causes neurologic dysfunctions, but the underlying molecular mechanisms are unclear...
  33. pmc Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis
    Svetlana Porfirova
    Department of Lothar Willmitzer, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Proc Natl Acad Sci U S A 99:12495-500. 2002
    Tocopherol (vitamin E) is a plant chloroplast lipid presumed to be involved in the response to oxidative stress. A tocopherol-deficient mutant (vte1) was isolated from Arabidopsis thaliana by using a TLC-based screening approach...
  34. ncbi Protective effects of melatonin and vitamin E in brain damage due to gamma radiation: an experimental study
    Fatih S Erol
    Department of Neurosurgery, Firat University School of Medicine, Elazig, Turkey
    Neurosurg Rev 27:65-9. 2004
    ..tissues of whole-body irradiated rats with likely radiation injury were compared to those with melatonin and vitamin E protection. Forty rats in four equal groups were used...
  35. ncbi Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial
    M Boaz
    Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Lancet 356:1213-8. 2000
    ..We investigated the effect of high-dose vitamin E supplementation on cardiovascular disease outcomes in haemodialysis patients with pre-existing cardiovascular ..
  36. ncbi Vitamin E regulates adipocytokine expression in a rat model of dietary-induced obesity
    Xiu Hua Shen
    Clinical Nutrition Center, Shanghai Xinhua Hospital, Shanghai 200092, China
    Exp Biol Med (Maywood) 235:47-51. 2010
    The aim of this study was to determine the effect of the antioxidant vitamin E (VE) on adiponectin and leptin expression in obese rats...
  37. ncbi Vitamin E and cancer
    Kimberly Kline
    Division of Nutrition, University of Texas at Austin, Texas 78712, USA
    Vitam Horm 76:435-61. 2007
    Perhaps not surprisingly, vitamin E which has been touted to be potentially beneficial for a variety of disorders, including cancer, heart disease, and even Alzheimer's disorder, based on its function as an antioxidant has failed to ..
  38. pmc gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
    Oxid Med Cell Longev 3:35-43. 2010
    ..Thus, these data suggest that gamma-tocotrienol protects against oxidative stress-induced cellular ageing by modulating the telomere length possibly via telomerase...
  39. ncbi Raxofelast, a hydrophilic vitamin E-like antioxidant, stimulates wound healing in genetically diabetic mice
    M Galeano
    Department of Plastic Surgery, University Hospital, University of Messina, ViaScite, 23 I-98124 Messina, Italy
    Surgery 129:467-77. 2001
    ....
  40. ncbi World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries
    J Villar
    Nuffield Department of Obstetrics and Gynaecology, Oxford Maternal and Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK
    BJOG 116:780-8. 2009
    ..To determine if vitamin C and E supplementation in high-risk pregnant women with low nutritional status reduces pre-eclampsia...
  41. ncbi Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study
    Riitta M Salonen
    Research Institute of Public Health, University of Kuopio, Finland
    Circulation 107:947-53. 2003
    Self-selected supplementation of vitamin E has been associated with reduced coronary events and atherosclerotic progression, but the evidence from clinical trials is controversial...
  42. ncbi Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants
    Y Miyake
    Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka
    Allergy 65:758-65. 2010
    Two previous cohort studies showed inverse relationships between maternal vitamin E and zinc intake during pregnancy and the risk of wheeze and/or asthma in the offspring...
  43. pmc Vitamin E is essential for seed longevity and for preventing lipid peroxidation during germination
    Scott E Sattler
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 16:1419-32. 2004
    Tocopherols (vitamin E) are lipophilic antioxidants synthesized by all plants and are particularly abundant in seeds...
  44. ncbi Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity
    Eva Maria Collnot
    Biopharmaceutics and Pharmaceutical Technology, Saarland University, 66123 Saarbrucken, Germany, Eastman Chemical Company
    Mol Pharm 4:465-74. 2007
    ..Besides small-molecule inhibitors, surfactants such as Tween 80, Cremophor EL, several Pluronics, and Vitamin E TPGS (TPGS 1000) are known to modulate efflux pump activity...
  45. ncbi Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    Stephen A Harrison
    Brooke Army Medical Center, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA
    Am J Gastroenterol 98:2485-90. 2003
    ..There is currently no proven medical therapy for the treatment of NASH. The aim of our study was to evaluate the efficacy of combination alpha-tocopherol (vitamin E) and vitamin C in reducing histologic inflammation and fibrosis.
  46. pmc Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials
    Markus Schürks
    Division of Preventive Medicine, Department of Medicine Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    BMJ 341:c5702. 2010
    To evaluate the effect of vitamin E supplementation on incident total, ischaemic, and haemorrhagic stroke.
  47. ncbi Effect of vitamin E and beta carotene on the incidence of primary nonfatal myocardial infarction and fatal coronary heart disease
    J Virtamo
    National Public Health Institute, Helsinki, Finland
    Arch Intern Med 158:668-75. 1998
    ..Oxidized low-density lipoprotein is involved in the pathogenesis of atherosclerosis. In epidemiological studies antioxidants have been inversely related with coronary heart disease. Findings from controlled trials are inconclusive...
  48. ncbi Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, ON
    N Engl J Med 342:154-60. 2000
    Observational and experimental studies suggest that the amount of vitamin E ingested in food and in supplements is associated with a lower risk of coronary heart disease and atherosclerosis.
  49. ncbi No effect of antioxidant supplementation on muscle performance and blood redox status adaptations to eccentric training
    Anastasios A Theodorou
    Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece
    Am J Clin Nutr 93:1373-83. 2011
    ..It was recently reported that antioxidant supplementation decreases training efficiency and prevents cellular adaptations to chronic exercise...
  50. pmc Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats
    Michael J Ryan
    Laboratory of Muscle Biology and Sarcopenia, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Exp Gerontol 45:882-95. 2010
    ..The rats were randomly assigned to a diet supplemented with Vitamin E and Vitamin C or normal non-supplemented rat chow...
  51. ncbi Vitamin E: the shrew waiting to be tamed
    Regina Brigelius-Flohe
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Biochemistry of Micronutrients, Nuthetal, Germany
    Free Radic Biol Med 46:543-54. 2009
    b>Vitamin E is the last of all vitamins whose essentiality is not yet understood. Its widely accepted role as a lipophilic antioxidant has been questioned, since proof of its in vivo relevance remained scarce...
  52. ncbi Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury
    Valeria Conte
    Head Injury Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurochem 90:758-64. 2004
    ..This study evaluated the effects of vitamin E on these four parameters in Tg2576 mice following RCBI...
  53. ncbi Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Diabetes 55:2856-62. 2006
    We directly assessed the efficacy of vitamin E supplements for primary prevention of type 2 diabetes among apparently healthy women in the Women's Health Study randomized trial. Between 1992 and 2004, 38,716 apparently healthy U.S...
  54. ncbi Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols
    Bao Liang Song
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 281:25054-61. 2006
    ..Degradation of HMG-CoA reductase is also stimulated by various forms of vitamin E, a generic term for alpha-, beta-, delta-, and gamma-tocopherols and tocotrienols, which are primarily ..
  55. ncbi The modulatory effects of ellagic acid and vitamin E succinate on TCDD-induced oxidative stress in different brain regions of rats after subchronic exposure
    Ezdihar A Hassoun
    College of Pharmacy, University of Toledo, Toledo, OH 43606, USA
    J Biochem Mol Toxicol 18:196-203. 2004
    The effects of ellagic acid (EA) and vitamin E succinate (VES) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress in different brain regions of rats have been studied after subchronic exposure to the compounds...
  56. ncbi Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel
    Si Shen Feng
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 30:3297-306. 2009
    ..as a model drug, which include the poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs), the poly(lactide)-vitamin E TPGS nanoparticles (PLA-TPGS NPs), the poly(lactic-co-glycolic acid)-montmorillonite nanoparticles (PLGA/MMT NPs)..
  57. ncbi Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial
    David D Waters
    Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
    JAMA 288:2432-40. 2002
    ..Hormone replacement therapy (HRT) and antioxidant vitamins are widely used for secondary prevention in postmenopausal women with coronary disease, but no clinical trials have demonstrated benefit to support their use...
  58. pmc Plasma urate and progression of mild cognitive impairment
    Michael C Irizarry
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurodegener Dis 6:23-8. 2009
    ..Impaired antioxidant defenses are implicated in neurodegenerative disease. The plasma levels of urate, a water-soluble antioxidant, are reduced in Alzheimer's disease (AD)...
  59. ncbi Reduction of wear volume from ultrahigh molecular weight polyethylene knee components by the addition of vitamin E
    Satoshi Teramura
    Graduate School of Engineering, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto, Kyoto 606 8501, Japan
    J Orthop Res 26:460-4. 2008
    Wear performance and debris-size distribution of vitamin E (DL-alpha tocopherol, VE)-added ultrahigh molecular weight polyethylene (UHMWPE) was evaluated using a knee-simulator test. VE was mixed with GUR 1050 UHMWPE powder at 0...
  60. ncbi Vitamin E chemistry. Nitration of non-alpha-tocopherols: products and mechanistic considerations
    Anjan Patel
    Department of Chemistry, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A 1190 Vienna, Austria
    J Org Chem 72:6504-12. 2007
    ..Bisnitration was only insignificantly disfavored by the first nitro group, so that under normal nitration conditions offering an excess of nitrating species only the bisnitration product was found...
  61. ncbi A novel dietary intervention to optimize vitamin E intake of pregnant women to 15 mg/day
    Julia Clark
    Public Health Nutrition Research Group, Health Sciences Building, First Floor, University of Aberdeen, Aberdeen AB25 2ZD, UK
    J Acad Nutr Diet 112:297-301. 2012
    Associations have been reported between suboptimal maternal vitamin E intake during pregnancy and childhood asthma...
  62. ncbi Targeted co-delivery of docetaxel and siPlk1 by herceptin-conjugated vitamin E TPGS based immunomicelles
    Jing Zhao
    Department of Bioengineering, Faculty of Engineering, National University of Singapore, Block EA, 03 12, 9 Engineering Drive 1, Singapore 117576, Singapore
    Biomaterials 34:3411-21. 2013
    We developed a drug delivery system of herceptin-conjugated micelles, which consist of vitamin E TPGS and TPGS-siRNA conjugates, for targeted co-delivery of docetaxel and polo-like kinase 1 siRNA to achieve synergistic effects between ..
  63. pmc Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts
    Suzana Makpol
    Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Biochemistry, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 67:135-43. 2012
    ..The beneficial effects of vitamin E in aging have been established, but studies to determine the mechanisms of these effects are ongoing...
  64. pmc Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory?
    Maaike Berbee
    Department of Radiation Oncology MAASTRO, GROW Research Institute, Maastricht University Medical Center, Maastricht, The Netherlands
    Curr Opin Support Palliat Care 6:54-9. 2012
    ..To give an overview of promising novel agents under development for the prevention and reduction of gastrointestinal radiation injury...
  65. pmc Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials
    Yizhou Ye
    Department of Cardiovascular Surgery, Shanghai First People s Hospital, Shanghai Jiaotong University, Shanghai, China
    PLoS ONE 8:e56803. 2013
    Antioxidant vitamin (vitamin E, beta-carotene, and vitamin C) are widely used for preventing major cardiovascular outcomes. However, the effect of antioxidant vitamin on cardiovascular events remains unclear.
  66. ncbi The vitamin E reduces liver lipoperoxidation and fibrosis in a model of nonalcoholic steatohepatitis
    Idilio Zamin Jr
    Post Graduation Program in Hepatology, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Porto Alegre, RS, Brazil
    Arq Gastroenterol 47:86-92. 2010
    ..No effective treatment is available for nonalcoholic steatohepatitis in nowadays...
  67. ncbi Direct inhibition of osteoclast formation and activity by the vitamin E isomer gamma-tocotrienol
    Roger Brooks
    Orthopaedic Research Unit, Addenbrooke s Hospital, Cambridge, UK
    Int J Vitam Nutr Res 81:358-67. 2011
    b>Vitamin E homologues, specifically tocotrienols, have been shown to have favorable effects on bone. They possess properties that are indicative of anti-resorptive activity, suggesting the potential for vitamin E in preventing bone loss...
  68. ncbi Lower vitamin E serum levels are associated with osteoporosis in early postmenopausal women: a cross-sectional study
    José M Mata-Granados
    Department of I D i, Sanyres Group, 14012, Cordoba, Spain
    J Bone Miner Metab 31:455-60. 2013
    The aim of this study was to evaluate the relationship between vitamin E status and osteoporosis in early postmenopausal women...
  69. pmc Vitamin E and all-cause mortality: a meta-analysis
    Erin L Abner
    Sanders Brown Center on Aging, University of Kentucky, KY 40536, USA
    Curr Aging Sci 4:158-70. 2011
    The current analysis reexamines the relationship between supplemental vitamin E and all-cause mortality...
  70. pmc Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD
    Miriam B Vos
    Pediatrics, Emory University, Atlanta, GA, USA
    J Pediatr Gastroenterol Nutr 54:90-6. 2012
    ..Although changes in diet are often recommended to improve NAFLD, little is known regarding the influence of diet on histologic features of the disease...
  71. ncbi Vitamin E supplementation and mammalian lifespan
    Ruth Banks
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
    Mol Nutr Food Res 54:719-25. 2010
    b>Vitamin E refers to a family of several compounds that possess a similar chemical structure comprising a chromanol ring with a 16-carbon side chain...
  72. ncbi Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration
    Stephen Beatty
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford City, Waterford, Republic of Ireland
    Ophthalmology 120:600-6. 2013
    ..To report the secondary outcomes in the Carotenoids with Coantioxidants in Age-Related Maculopathy trial...
  73. ncbi In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma
    Lars Muller
    Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany
    Mol Nutr Food Res 54:731-42. 2010
    ..alpha-tocopherol equivalent antioxidant capacity no significant differences in the antioxidant activity of all vitamin E isoforms were found...
  74. ncbi Is vitamin E toxic to neuron cells?
    Sue Mian Then
    UKM Medical Molecular Biology Institute UMBI, Universiti Kebangsaan Malaysia Medical Centre UKMMC, Universiti Kebangsaan Malaysia, 7th Floor Clinical Block, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia
    Cell Mol Neurobiol 29:485-96. 2009
    ....
  75. ncbi Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats
    S Atasayar
    Department of Toxicology, Hacettepe University, Sihhiye, Ankara, Turkey
    Exp Toxicol Pathol 61:23-32. 2009
    ..The nephrotoxicity was confirmed biochemically by significant elevation of serum urea and creatinine levels. Both vitamin C-E combination and aminoguanidine prevented the increase in serum urea levels according to the cisplatin group...
  76. ncbi Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats
    Mustafa Naziroglu
    Department of Physiology, Veterinary Faculty, Firat University, TR 23119, Elazig, Turkey
    Toxicology 195:221-30. 2004
    ..In the present study, we investigated the effect of selenium with high dose vitamin E administration on lipid peroxidation (MDA) and scavenging enzyme activity in kidneys, liver and lens of ..
  77. ncbi Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors
    Ramaswamy Kannappan
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 9:2196-207. 2010
    ..We investigated the ability of tocotrienol (T3), an unsaturated vitamin E present in palm oil, rice bran, barley, oats, and wheat germ, to sensitize tumor cells to TRAIL...
  78. ncbi Comparative effects of palm vitamin E and alpha-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats
    M Musalmah
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    Lipids 40:575-80. 2005
    The effect of supplementing 200 mg/kg body weight palm vitamin E (PVE) and 200 mg/kg body weight alpha-tocopherol (alpha-Toc) on the healing of wounds in streptozotocin-induced diabetic rats was evaluated...
  79. ncbi Effects of vitamin E supplementation on bone metabolism in nicotine-treated rats
    M Norazlina
    Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    Singapore Med J 48:195-9. 2007
    Nicotine has been shown to exert negative effects on bone. This study determined whether vitamin E supplementation is able to repair the nicotine-induced adverse effects in bone.
  80. ncbi Lipid peroxidation and antioxidant status in preeclampsia: a systematic review
    Sajal Gupta
    Glickman Urological and Kidney Institute, Cleveland, OH 44195, USA
    Obstet Gynecol Surv 64:750-9. 2009
    ..Preeclampsia is characterized by increased lipid peroxidation and diminished antioxidant capacity; however, there is no consensus as to the extent of these conditions...
  81. ncbi A randomized trial of vitamin E supplementation and cognitive function in women
    Jae Hee Kang
    Channing Laboratory, Boston, MA 02115, USA
    Arch Intern Med 166:2462-8. 2006
    Oxidative stress may play a key role in the development of cognitive impairment. Long-term supplementation with vitamin E, a strong antioxidant, may provide cognitive benefits.
  82. ncbi The alpha-tocopherol transfer protein
    D Manor
    Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
    Vitam Horm 76:45-65. 2007
    ..This activity was later ascribed to vitamin E, a term comprising a number of structurally related plant lipids that function as fat soluble antioxidants...
  83. ncbi Role of gastric mucosal ascorbic acid in gastric mucosal lesion development in rats with water immersion restraint stress
    Yoshiji Ohta
    Department of Chemistry, School of Medicine, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Inflammopharmacology 13:249-59. 2005
    ..onset of WIRS, while gastric mucosal non-protein SH concentration decreased at 1, 3, and 6 h and gastric mucosal vitamin E concentration decreased at 6 h...
  84. pmc Engineering vitamin E content: from Arabidopsis mutant to soy oil
    Alison L Van Eenennaam
    Monsanto Company, Calgene Campus, Davis, California 95616, USA
    Plant Cell 15:3007-19. 2003
    We report the identification and biotechnological utility of a plant gene encoding the tocopherol (vitamin E) biosynthetic enzyme 2-methyl-6-phytylbenzoquinol methyltransferase...
  85. ncbi Oxidative stress response in normal and antioxidant supplemented rats to a downhill run: changes in blood and skeletal muscles
    Tongjian You
    Gerontology and Geriatric Medicine, Wake Forest U School of Medicine, Winston Salem, NC 27157, USA
    Can J Appl Physiol 30:677-89. 2005
    ..Sprague-Dawley rats were pretreated with a normal rat diet or diet + antioxidants (2,000 mg vitamin C + 1,000 IU vitamin E/kg diet) for 2 weeks...
  86. ncbi Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access
    Eva Maria Collnot
    Biopharmaceutics and Pharmaceutical Technology, Saarland University, 66123 Saarbrucken, Germany
    Mol Pharm 7:642-51. 2010
    ....
  87. ncbi The use of vitamin E in type 2 diabetes mellitus
    Riham Zein Fardoun
    Heart and Kidney Institute, University of Houston, College of Pharmacy, Houston, Texas 77204, USA
    Clin Exp Hypertens 29:135-48. 2007
    ..Finally, a review of the use of the antioxidant vitamin E will be provided in diabetic patients by assessing and evaluating some of the clinical trials in the literature.
  88. ncbi Vitamin E and immunity after the Kona Triathlon World Championship
    David C Nieman
    Department of Health and Exercise Science, Fischer Hamilton Nycom Biochemistry Laboratory, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 36:1328-35. 2004
    To measure the influence of vitamin E ingestion on oxidative stress and immune changes in response to the Triathlon World Championship in Kona, Hawaii.
  89. ncbi Glutathione, vitamin E and oxidative stress in coronary artery disease: relevance of age and gender
    V Cavalca
    Department of Cardiovascular Sciences, University of Milan, Milan, Italy
    Eur J Clin Invest 39:267-72. 2009
    ..We investigated whether the biomarkers of oxidative balance undergo the same modifications in all CAD patient groups, regardless of gender and age...
  90. pmc Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease
    Paul G Shekelle
    Southern California Evidence Based Practice Center, RAND Corporation, Santa Monica, California, USA
    J Gen Intern Med 19:380-9. 2004
    To evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease.
  91. ncbi Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
    M Carola Zillikens
    Department of Internal Medicine, Room D428, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Clin Nutr 91:1387-93. 2010
    ..Genetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity. SIRT1 may be influenced by diet...
  92. ncbi Effect of vitamin E on monosodium glutamate induced hepatotoxicity and oxidative stress in rats
    Oscar Okwudiri Onyema
    Toxicology Unit, Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria
    Indian J Biochem Biophys 43:20-4. 2006
    ..b>Vitamin E (0...
  93. ncbi Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases
    Goran Bjelakovic
    Department of InternalMedicine, Medical Faculty, University ofNis, Nis, Serbia
    Cochrane Database Syst Rev 3:CD007176. 2012
    ..Our systematic review has demonstrated that antioxidant supplements may increase mortality. We have now updated this review...
  94. pmc The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology
    Dolph L Hatfield
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Interv 9:18-21. 2009
    The recently completed Selenium and Vitamin E Cancer Prevention Trial (SELECT) was one of the largest human cancer prevention trials ever undertaken...
  95. ncbi Administration of vitamin E and losartan as prophylaxes in cisplatin-induced nephrotoxicity model in rats
    Mehdi Nematbakhsh
    Kidney Basic Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
    J Nephrol 25:410-7. 2012
    ..The present study was designed to compare the effect of losartan and vitamin E as prophylaxes against CDDP-induced nephrotoxicity.
  96. ncbi Effects of vitamin E against aluminum neurotoxicity in rats
    V S Nedzvetsky
    Department of Biophysics and Biochemistry, Faculty of Biology, Dnepropetrovsk National University, Ukraine
    Biochemistry (Mosc) 71:239-44. 2006
    The present study examined the protective effects of vitamin E against aluminum-induced neurotoxicity in rats. Wistar rats were given daily aluminum via their drinking water containing 1600 mg/liter aluminum chloride for six weeks...
  97. ncbi Protective role of intraperitoneally administered vitamin E and selenium on the antioxidative defense mechanisms in rats with diabetes induced by streptozotocin
    M Naziroglu
    Department of Physiology, Veterinary Faculty of Firat University, Elazig, Turkey
    Biol Trace Elem Res 79:149-59. 2001
    The aim of this work was to determine the protective effects of intraperitoneally administered vitamin E and selenium (as Na2SeO3, Se) on the lipid peroxidation as thiobarbituric acid reactive substances (TBARS) and vitamin E levels, ..
  98. ncbi Regional responses in antioxidant system to exercise training and dietary vitamin E in aging rat brain
    S Asha Devi
    Department of Zoology, Laboratory of Gerontology, Bangalore University, Bangalore 560 056, India
    Neurobiol Aging 25:501-8. 2004
    We have evaluated the effect of exercise, Vitamin E and a combination of both on the antioxidant enzymes (AOEs)-superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) along with the products of lipid peroxidation (..
  99. pmc Genetic dissection of vitamin E biosynthesis in tomato
    Juliana Almeida
    Departamento de Botânica IB USP, 277, 05508 900, Sao Paulo, SP, Brazil
    J Exp Bot 62:3781-98. 2011
    Vegetables are critical for human health as they are a source of multiple vitamins including vitamin E (VTE)...
  100. ncbi Influence of dietary vitamin E supplementation on meat quality traits and gene expression related to lipid metabolism in the Beijing-you chicken
    W J Li
    Chinese Academy of Agricultural Sciences, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Beijing, China
    Br Poult Sci 50:188-98. 2009
    1. The effects of dietary vitamin E (DL-alpha-tocopheryl acetate) on carcase and meat quality, oxidative stability, fatty acid composition of muscle lipids, and gene expression related to lipid metabolism were studied in Beijing-you ..
  101. ncbi Antioxidative therapy in contusion spinal cord injury
    A F Cristante
    Institute of Orthopedics and Traumatology, Clinics Hospital, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos, Sao Paulo, Sao Paulo, Brazil
    Spinal Cord 47:458-63. 2009
    ..Some studies have made use of the antioxidative capabilities of high doses of vitamins C and E with the aim of neutralizing the noxious effects of free radicals following spinal cord lesion...

Research Grants71

  1. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..daily to one of four intervention groups based on a 2x2 factorial design: β-carotene (20 mg/day), vitamin E (50 mg/day, as dl-α-tocopheryl acetate), both agents, or placebo...
  2. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2012
    ..Moreover, we also show that Superoxide dismutase 1 (SOD1), Vitamin E, and genetically overexpressed human SOD1 (hSOD1) is able to reverse the glossy eye phenotype of dOPA1 mutant ..
  3. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ..Similar results have been reported with many other nutrients and nutrient derivatives (ie, vitamin A, vitamin E, etc)...
  4. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..In order to scavenge oxidized reactive nitrogen species vitamin E will be administered via dietary supplementation...
  5. TNF and Mitochondrial Dysfunction in ALD
    Craig J McClain; Fiscal Year: 2010
    ..g., GSH and Vitamin E),generation of reactive oxygen intermediates, altered methionine metabolism, decreased cAMP, activation of ..
  6. Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and Prosta
    Iona Cheng; Fiscal Year: 2012
    ..tumors), environmental factors related to mitochondrial activity (smoking, BMI, fat, carotenoids, vitamin C, vitamin E, iron, lycopene and selenium) and susceptibility loci for breast, colorectal and/or prostate cancer identified ..
  7. Pregnancy, Pre-eclampsia, Anti-oxidants and Endothelial Cell Function
    Gautam Chaudhuri; Fiscal Year: 2010
    ..A much larger trial utilizing the anti-oxidants vitamin C and vitamin E is, at present, being carried out by the Maternal-Fetal Network of the NICHD to assess their effectiveness in ..
  8. Intervention of Pancreatic Oncogenic Pathways with Dietary Tocotrienol
    Mokenge P Malafa; Fiscal Year: 2012
    ..Tocotrienols, the predominant vitamin E compounds in cereal foods, have been proposed as potential anticancer agents due to their clinical safety as ..
  9. Reactive Oxygen Species Signaling in the Hippocampus
    Eric Klann; Fiscal Year: 2012
    ..increased eIF2[unreadable] phosphorylation exhibited by the Tg2576 mice could be prevented by the anti-oxidant vitamin E. Therefore, we examined the levels of eIF2[unreadable] phosphorylation in Tg2576 mice that were crossed with the ..
  10. HIV, HCV and Liver Disease Among Injection Drug Users in Chennai, India
    Shruti H Mehta; Fiscal Year: 2013
    ..2. To conduct a double-blinded placebo controlled randomized clinical trial to determine the efficacy of Vitamin E for the treatment of steatosis...
  11. A Developmental And Molecular Investigation Of How Vitamin E Ameliorates Endocrin
    Krista McCoy; Fiscal Year: 2013
    ..However, we recently discovered that supplementing EDC-exposed mice with vitamin E reduces the severity of hypospadias in their sons...
  12. Myocardial salvage via coordinated induction of endogenous cardiac antioxidants
    Yunbo Li; Fiscal Year: 2010
    ..However, clinical trials on use of exogenous antioxidants, including vitamin E in management of CVD have reached disappointing conclusions...
  13. The Role of a Novel Vitamin E Metabolite in Colon Cancer Prevention and Therapy
    Qing Jiang; Fiscal Year: 2012
    ..We have recently demonstrated that vitamin E forms including 3-tocopherol (3T), 4-tocopherol (4T) and 3-tocotrienol (3TE) are metabolized to long-chain ..
  14. Risk Factors for Craniosynostosis
    Suzan L Carmichael; Fiscal Year: 2010
    ..acid, choline, betaine, methionine, vitamin B12, vitamin B6, riboflavin, glycemic load, [unreadable]-carotene, vitamin E, and vitamin C. Aim 2. Factors related to thyroid dysfunction...
  15. Importance of Gender in the Chemoprevention of UV induced Skin Cancer
    Tatiana M Oberyszyn; Fiscal Year: 2013
    ..2 are designed to determine the differential chemopreventive effects of topical treatment with an antioxidant (vitamin E), an anti-inflammatory drug (celebrex), a natural antioxidant/anti-inflammatory agent (Black Raspberry extract) ..
  16. Epigenetic Dysregulation by Oxidative Stress from Environmental Insults
    Suresh Cuddapah; Fiscal Year: 2013
    ..Specificity to oxidative stress will be examined using antioxidants such as reduced ascorbate or vitamin E. We will map on a genome-wide scale epigenetic modifications that are affected by the inhibition of oxidative ..
  17. Novel mycobacterial translocase I inhibitors - a new class of anti-TB drugs
    Venkata M Reddy; Fiscal Year: 2010
    ..Fortunately, we solved both efflux and insolubility problems by combining SQ641 with TPGS, a vitamin E analogue routinely used to improve drug solubility and hence bioavailability (EASTMAN and Company 2005)...
  18. Anti-Inflammatory Interventions in Maintenance Hemodialysis Patients
    Talat Alp Ikizler; Fiscal Year: 2013
    ..therapies in MHD patients, including Interleukin-1 receptor antagonist (IL-1ra), Fish Oil (EPA+DHA), Vitamin E (gamma-tocopherol), alpha lipoic acid (ALA) and CoEnyzme Q10 in studies ranging from 14 patients to 300 patients...
  19. Oxidative insults, antioxidative responses and type 1 diabetes complications
    Tina Costacou; Fiscal Year: 2010
    ..clinical trials results have generally not supported a protective effect of 1-tocopherol (the most active vitamin E form) supplementation on, especially, heart disease...
  20. Cumulative Stress and CVD Risk in Middle-Aged and Older Women
    Michelle A Albert; Fiscal Year: 2013
    ..The WHS was initiated in 1992 as a randomized trial of aspirin and vitamin E in the primary prevention of cancer and cardiovascular disease among 39, 876 female health professionals aged 45 ..
  21. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2010
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E).
  22. Prostate cancer prevention by tocopherols
    Ah Ng Tony Kong; Fiscal Year: 2013
    ..Significance of the Proposed Research: Selenium and Vitamin E Cancer Prevention Trial (SELECT), a clinical trial to determine if one or both of these cancer chemopreventive ..
  23. Forms of Vitamin E Have Opposing Effects on Inflammation
    Joan M Cook-Mills; Fiscal Year: 2011
    b>Vitamin E has been suggested to exert anti-inflammatory actions and has been shown to be effective in reducing inflammation in experimental asthma in mice and in asthmatics in studies in several countries in Europe (Finland and Italy)...
  24. SOUTHWEST ONCOLOGY GROUP
    Gary E Goodman; Fiscal Year: 2013
    ..The Selenium and Vitamin E Trial has accrued 960 patients, the SELECT Ancillary Study accrued 191 patients, and the UCOP program accrued 43 ..
  25. Atlanta Regional Community Clinical Oncology Program (ARCCOP)
    Thomas E Seay; Fiscal Year: 2012
    ..The ARCCOP is a clinical site for the Study of Tamoxifen and Raloxefene (STAR) and the Selenium and Vitamin E Cancer Prevention Trial (SELECT) for breast and prostate cancer prevention respectively...
  26. Mitochondrial Genetic Susceptibility to Breast and Prostate Cancers
    Iona Cheng; Fiscal Year: 2013
    ..tumors), environmental factors related to mitochondrial activity (smoking, BMI, fat, carotenoids, vitamin C, vitamin E, iron, lycopene and selenium) and susceptibility loci for breast and prostate cancer identified by genome-wide ..
  27. Prophylactic Use of Vitamin E for Prevention of Occupational PAH-Induced Damage
    Debbie Mustacich; Fiscal Year: 2009
    ..Levels of BP-DNA adducts in cigarette smokers are decreased by vitamin E (a-tocopherol) administration...
  28. Vitamin E Requirements in Women,Obese Women and Diabetic Obese Women
    Maret G Traber; Fiscal Year: 2013
    ..Epidemiologic studies suggest that chronic disease risk can be reduced by a lifetime of consuming higher dietary vitamin E intakes...
  29. Prevention of estrogen-mediated mammary carcinogenesis by mixtures of tocopherols
    Nanjoo Suh; Fiscal Year: 2013
    ..provided by applicant): Tocopherols are naturally occurring phenolic compounds and are the major forms of vitamin E in our body...
  30. Colorectal Neoplasia in SELECT Participants
    M PETER LANCE; Fiscal Year: 2011
    ..The SELECT Trial will assess the effect of selenium, as L-selenomethionine, and vitamin E alone and in combination on the clinical incidence of prostate cancer in 35,584 now-randomized male subjects...
  31. Reactive Oxygen Species and Telomeres in Cardiovascular Disease
    CARRIE ANN JESSICA OLIVIA GORDON; Fiscal Year: 2013
    ..In Aim 3, I will determine if the anti-atherosclerotic agents estrogen and vitamin E reverse ROS-dependent deficits in telomere maintenance...
  32. Factors Modifying the Toxicity of Methylmercury in a Fish-Eating Population
    Philip W Davidson; Fiscal Year: 2013
    ..the apparent effect modification seen in their earlier study may have been due to anti- oxidants (selenium and vitamin E) in the maternal diet, as well as the anti-inflammatory effects of n-3 PUFA from fish consumption...
  33. Molecular pathogenesis of alpha-tocopherol associated neuroaxonal dystrophy in an
    Carrie Finno; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite several decades of research, our understanding of the role that vitamin E, specifically a-tocopherol, plays in health and disease remains quite limited...
  34. Tocopherol-mediated inhibition of breast carcinogenesis
    Nanjoo Suh; Fiscal Year: 2010
    ..preliminary studies, we hypothesize that gamma- and delta-tocopherols, not alpha-tocopherol (known as a classic vitamin E), prevent breast cancer by inhibiting cell proliferation, inflammation, and oxidative stress, and by regulating ..
  35. Predisposing Factors for the Development of Atrial Fibrillation Among Women
    Christine M Albert; Fiscal Year: 2010
    ..The relationship between randomized vitamin E treatment and non-randomized statin therapy and AF will also be assessed...
  36. Early Life DNA Methylation and Childhood Allergic Disease
    Augusto A Litonjua; Fiscal Year: 2013
    ..2) To examine whether prenatal exposures such as prenatal diet (antioxidants, primarily vitamin E), maternal smoking, and exposure to ambient air pollution affect differential methylation of genes related to ..
  37. Human Cytochrome P450 4F Enzymes and Drug Interactions
    ZHUO MICHAEL WANG; Fiscal Year: 2013
    ..arachidonic acid and leukotrienes B4 (LTB4), and drugs/nutrients, including pafuramidine, fingolimod, and vitamin E. However, the role of CYP4F enzymes in mediating potential drug interactions remains uncharacterized...
  38. Chemoprevention of arsenic-induced skin cancer
    Habibul Ahsan; Fiscal Year: 2013
    ..To identify an effective preventive approach for this increased risk we established the Bangladesh vitamin E and selenium Trial (BEST)-a 2W2 factorial randomized chemoprevention trial (RCT) for evaluating whether long- ..
  39. Non-pharmacological control of atherosclerosis
    Sampath Parthasarathy; Fiscal Year: 2013
    ..In lieu of vitamin E's failure in protecting human atherosclerosis, identification of the mechanisms by which the non-..
  40. Clinical Research on Nonalcoholic Fatty Liver Disease
    JOEL EDWARD LAVINE; Fiscal Year: 2013
    ..called "TONIC", has 173 subjects enrolled for a 2-year treatment, assessing safety and efficacy of metformin or Vitamin E versus placebo...
  41. Women's Health Study: Continued Follow-up
    I Min Lee; Fiscal Year: 2013
    ..The WHS began in 1992 as a randomized trial of aspirin and vitamin E in the primary prevention of cancer and CVD among 39,876 female health professionals aged e45 years, ending in ..
  42. Health system based clinical trial recruitment
    Trevor J Orchard; Fiscal Year: 2011
    ..Hp 2-2 genotype and retrospective analyses of the HOPE trial showed a reduction in MI and CVD death rates with vitamin E only in the group with diabetes and the Hp 2-2 genotype...
  43. Prevention of Metastatic Cancer Using a Novel Vitamin E Analog
    Emmanuel T Akporiaye; Fiscal Year: 2010
    ..Alpha-TEA is a lipophilic, esterase resistant, semi-synthetic analog of naturally-occurring vitamin E (RRR-alpha-tocopherol) that selectively induces apoptosis of cancer cells in vitro and suppresses tumor growth ..
  44. Prevention of PTEN deletion driven prostate cancer by selenium
    Junxuan Lu; Fiscal Year: 2012
    ..However, the NCI stopped the Selenium and vitamin E Cancer prevention Trial (SELECT) in October 2008 ahead of schedule because of the failure to demonstrate an ..
  45. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2009
    ..and monounsaturated fats, the n-3 fatty acids, alpha-linolenic acid and eicosapentaenoic acid, vitamin C, and vitamin E supplement use were unclear or marginally significant...
  46. PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research
    Ian M Thompson; Fiscal Year: 2013
    ..in Seattle served as the coordinating center for two large prostate cancer prevention trials, the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and the Prostate Cancer Prevention Trial (PCPT)...
  47. Functions of Tocopherol Transfer Protein
    Danny Manor; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Vitamin E (tocopherol) is the major fat-soluble antioxidant in humans, and serves a critical function in protection against a plethora of oxidative-stress-related pathologies...
  48. Oxidative Stress, Antioxidants and Racial Disparities in Prostate Cancer
    Cathryn H Bock; Fiscal Year: 2011
    ..assess whether variation in these genes modifies prostate cancer risk associated with intake of the antioxidants vitamin E, selenium and lycopene...
  49. Codrugs of Lipoic Acid and Tocopherol/Tocopheramine for Use as Photoprotective Ag
    Martha A Hass; Fiscal Year: 2011
    ..These novel compounds are derived from naturally-occurring vitamin E (TOC, tocopherols) and vitamin E analogs (tocopheramines) and lipoic acid or lipoic acid derivatives (LA)...
  50. Baby Observational and Nutritional Study of Cystic Fibrosis
    Bonnie W Ramsey; Fiscal Year: 2013
    ..malnutrition are significant and include permanent stunting of stature (2, 3), cognitive dysfunction linked to vitamin E deficiency (4, 5) and more rapid decline in pulmonary function...
  51. The Women's Health Study: Addition of New Data to Maximize its Research Impact
    Julie E Buring; Fiscal Year: 2010
    ..The WHS began in 1992 as a randomized trial of aspirin and vitamin E in the primary prevention of CVD and cancer among 39,876 female health professionals aged e45 years...
  52. Anti-oxidant therapy in Alzheimer's disease
    Brian J Bacskai; Fiscal Year: 2010
    ..traditional and alternative sources to systematically evaluate whether compounds like ginkgo biloba extract, vitamin E, or grape seed extract are effective anti- oxidants for Alzheimer's disease treatment...
  53. Physicians'Health Study II: Prevention Trial of Vitamins
    J Michael Gaziano; Fiscal Year: 2011
    ..component of the Physicians Health Study II, an ongoing randomized, double-blind, placebo- controlled trial of vitamin E, vitamin C, and a multivitamin, in the prevention of cancer, cardiovascular disease, eye disease, and decline in ..
  54. Oxidation Hypothesis Revisited: Haptoglobin Genotype &Diabetic Atherosclerosis
    ANDREW PETER LEVY; Fiscal Year: 2013
    ..tested this approach in a double-blind placebo controlled trial and found that antioxidant therapy with vitamin E significantly reduced atherothrombosis in Hp 2-2 DM individuals...
  55. Brain aging and antioxidant supplementation
    Michael J Forster; Fiscal Year: 2010
    The endogenous antioxidants vitamin E, vitamin C, and coenzyme Q (CoQ) are thought to have significant interactions in the maintenance of cellular redox state and in cellular protection form oxidative insult...
  56. Anti-inflammatory mechanisms, pharmacokinetics of novel metabolites of vitamin E
    Qing Jiang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Vitamin E supplementation has been commonly used as a CAM (Complementary and Alternative Medicine)...
  57. Prospective study of biomarkers and risk factors for ALS incidence and progressio
    Alberto Ascherio; Fiscal Year: 2013
    ..the past 5 years of this project, we have found that ALS risk was inversely associated with long term intakes of vitamin E and other antioxidants, and positively associated with cigarette smoking...
  58. Tocopherylquinone as a novel chemopreventive agent for prostate cancer
    TODD ANTHONY THOMPSON; Fiscal Year: 2010
    ..It has been noted in several studies that men who both smoke and take supplemental vitamin E have a significantly reduced incidence of prostate cancer development...
  59. Antioxidants and Membrane Repair
    Paul L McNeil; Fiscal Year: 2012
    ..Preliminary results reveal that vitamin E potently enhances defective plasma membrane repair in both HeLa and C2C12 cells...
  60. Mechanics and Performance of Traceable UHMWPE Implants
    STEVEN MICHAEL KURTZ; Fiscal Year: 2013
    ..Thus, successful achievement of the proposed research will provide essential information on THR implant performance and clinical outcomes, which are needed for informed health care decisions. ..
  61. Mechanisms and Prevention of Etoposide-Induced Leukemia
    Jack C Yalowich; Fiscal Year: 2011
    ..We further posit that nutritional antioxidants such as vitamin C and vitamin E homologs will prevent VP-16-induced AML by reducing or preventing production of peroxidase-dependent free ..
  62. Epidemiologic Study of Brain Vitamin E, Diet &Age-Related Neurologic Diseases
    Martha Clare Morris; Fiscal Year: 2012
    ..by applicant): This is the second revision of an application (1 R01 NS056397), "Epidemiologic Study of Brain Vitamin E, Diet and Age-Related Neurologic Diseases", which was not funded...
  63. Quantitation of Tocopherol Metabolism in Humans
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): There is growing evidence that a-tocopherol, the active form of vitamin E, may help minimize the risk of certain chronic diseases such as cardiovascular disease, hypertension and cancer...
  64. Gamma-tocopherol as an effective anticancer agent for colon cancer
    Qing Jiang; Fiscal Year: 2010
    ..We propose that certain forms of vitamin E are excellent anti-cancer agents for colon cancer...
  65. EFFECT OF VITAMIN E ON HEPATOCYTE STRUCTURE AND FUNCTION
    Ronald Sokol; Fiscal Year: 1991
    b>Vitamin E is the primary membrane-localized antioxidant protecting cellular membranes from free radical-induced lipid peroxidation...
  66. Supplemental Se and Vitamin E and Pulmonary Function
    PATRICIA CASSANO; Fiscal Year: 2007
    This proposed project is a randomized clinical trial testing whether supplementation with selenium and/or vitamin E affects pulmonary function...
  67. Oxidative Stress in Alcoholic Cardiomyopathy
    Charles Lui; Fiscal Year: 2004
    ..is caused by long-term alcohol abuse in the setting of nutritional deficiency involving both selenium and vitamin E. Since selenium and vitamin E are important anti-oxidants, a deficiency state involving these two anti-oxidants ..
  68. MYOCARDIAL OXIDANT INJURY--KESHAN DISEASE AS A MODEL
    Raymond Burk; Fiscal Year: 1992
    ..Defenses against oxidant stress such as Se (acting through glutathione peroxidase), vitamin E, glutathione, and taurine would be expected to protect the myocardium...
  69. VITAMIN E ATHEROSCLEROSIS PREVENTION STUDY
    HOWARD HODIS; Fiscal Year: 1999
    ..b>Vitamin E supplementation has shown the most consistent association with reduction in CHD risk in asymptomatic men and ..
  70. BREATH ETHANE, BIOMARKER OF VITAMIN A AND E DEFICIENCY
    Kathleen Schwarz; Fiscal Year: 1993
    ..antioxidant activity in vitro, and breath ethane (a volatile product of lipid peroxidation) is a useful index of vitamin E deficiency...
  71. EXPERIMENTAL ANALYSIS OF AGING IN THE VERTEBRATE RETINA
    KATHERINE FITE; Fiscal Year: 1991
    ..At present, a major need exists for laboratory species with many of the characteristics seen in the human retina, but which age rapidly, as does the quail...