isoflavones

Summary

Summary: 3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.

Top Publications

  1. ncbi Interaction of phytoestrogens with estrogen receptors alpha and beta (II)
    Keiko Morito
    Department of Molecular and Cellular Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa, Japan
    Biol Pharm Bull 25:48-52. 2002
  2. ncbi Total extract and standardized fraction from the stem bark of Butea monosperma have osteoprotective action: evidence for the nonestrogenic osteogenic effect of the standardized fraction
    Rashmi Pandey
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Lucknow, India
    Menopause 17:602-10. 2010
  3. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
  4. ncbi Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy
    Ming Zhu Fang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Clin Cancer Res 11:7033-41. 2005
  5. ncbi The combination of TRAIL and isoflavones enhances apoptosis in cancer cells
    Joanna Bronikowska
    Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41 808 Zabrze, Poland
    Molecules 15:2000-15. 2010
  6. ncbi Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials
    Kyoko Taku
    National Institute of Health and Nutrition, Tokyo, Japan
    Menopause 19:776-90. 2012
  7. ncbi Estrogenic activities of isoflavones and flavones and their structure-activity relationships
    Sun Young Choi
    Food Function Research Group, Korea Food Research Institute, Gyeonggi Do, Republic of Korea
    Planta Med 74:25-32. 2008
  8. ncbi Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium
    P Diel
    , Deutsche Sporthochschule, , Germany
    Hum Reprod 16:997-1006. 2001
  9. ncbi The effects of soy isoflavones on obesity
    Anne Ørgaard
    Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    Exp Biol Med (Maywood) 233:1066-80. 2008
  10. ncbi Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats
    Li Ping Yan
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Life Sci 79:324-30. 2006

Research Grants

  1. Dietary Isoflavones, Tamoxifen, and Tumor Growth
    William Helferich; Fiscal Year: 2005
  2. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
  3. Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention
    EDWIN DOUGLAS LEPHART; Fiscal Year: 2010
  4. Soy isoflavones to augment radiotherapy of lung carcinoma
    Gilda G Hillman; Fiscal Year: 2012
  5. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2011
  6. Plant-based diets and risk of cancer
    Gary E Fraser; Fiscal Year: 2013
  7. Bacterial and Chemical Carcinogens in Gastric Oncogenesis
    D Scott Merrell; Fiscal Year: 2012
  8. Study of Soy Isoflavones in Asthma (SOYA)
    Lewis J Smith; Fiscal Year: 2013
  9. Study of Soy Isoflavones in Asthma (SOYA)
    Robert A Wise; Fiscal Year: 2013
  10. Urinary peptide excretion and onset of puberty
    Stephen Barnes; Fiscal Year: 2009

Detail Information

Publications338 found, 100 shown here

  1. ncbi Interaction of phytoestrogens with estrogen receptors alpha and beta (II)
    Keiko Morito
    Department of Molecular and Cellular Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa, Japan
    Biol Pharm Bull 25:48-52. 2002
    ..The results show that methylation or glucosidation of isoflavones generally inhibits their phytoestrogenic activities.
  2. ncbi Total extract and standardized fraction from the stem bark of Butea monosperma have osteoprotective action: evidence for the nonestrogenic osteogenic effect of the standardized fraction
    Rashmi Pandey
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Lucknow, India
    Menopause 17:602-10. 2010
    ....
  3. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
    ....
  4. ncbi Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy
    Ming Zhu Fang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Clin Cancer Res 11:7033-41. 2005
    ..To determine whether other polyphenolic compounds have similar activities, we studied the effects of soy isoflavones on DNA methylation.
  5. ncbi The combination of TRAIL and isoflavones enhances apoptosis in cancer cells
    Joanna Bronikowska
    Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41 808 Zabrze, Poland
    Molecules 15:2000-15. 2010
    b>Isoflavones are a class of bioactive polyphenols with cancer chemopreventive properties...
  6. ncbi Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials
    Kyoko Taku
    National Institute of Health and Nutrition, Tokyo, Japan
    Menopause 19:776-90. 2012
    This analysis was conducted to determine the efficacy of extracted or synthesized soybean isoflavones in the alleviation of hot flashes in perimenopausal and postmenopausal women.
  7. ncbi Estrogenic activities of isoflavones and flavones and their structure-activity relationships
    Sun Young Choi
    Food Function Research Group, Korea Food Research Institute, Gyeonggi Do, Republic of Korea
    Planta Med 74:25-32. 2008
    ..89 and q2 = 0.83). The prediction of estrogenicity with regard to ER beta reveals a positive correlation with the AlogP and Hbond acceptors, and a negative correlation with RadOfGyration (r2 = 0.77 and q2 = 0.72)...
  8. ncbi Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium
    P Diel
    , Deutsche Sporthochschule, , Germany
    Hum Reprod 16:997-1006. 2001
    ....
  9. ncbi The effects of soy isoflavones on obesity
    Anne Ørgaard
    Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    Exp Biol Med (Maywood) 233:1066-80. 2008
    ..The health benefits associated with soy consumption have been linked to the content of isoflavones, the main class of the phytoestrogens...
  10. ncbi Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats
    Li Ping Yan
    Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Life Sci 79:324-30. 2006
    ..Whether puerarin targets directly on cholesterol homeostasis or both cholesterol homeostasis and endothelial function remains to be determined...
  11. pmc Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity
    A Crespillo
    Laboratorio de Medicina Regenerativa, Hospital Carlos Haya, Fundacion IMABIS, Pabellón de Gobierno, Malaga, Spain
    Br J Pharmacol 164:1899-915. 2011
    ..From this perspective, we have analysed the effects of daidzein, one of the main soy isoflavones, on diet-induced obesity in rats.
  12. ncbi Puerarin induces angiogenesis in myocardium of rat with myocardial infarction
    Sanyin Zhang
    State Key Laboratory in Chinese Medicine and Molecular Pharmacology, Shenzhen, China
    Biol Pharm Bull 29:945-50. 2006
    ..From these results, we suggested that puerarin may induce therapeutic angiogenesis in myocardium of rat with MI. The mechanism may be that puerarin can induce VEGF and eNOS expression...
  13. ncbi Soy isoflavones, CYP1A1, CYP1B1, and COMT polymorphisms, and breast cancer: a case-control study in southwestern China
    Qiong Wang
    Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, PR China
    DNA Cell Biol 30:585-95. 2011
    CYP1A1, CYP1B1, and COMT are key enzymes involved in estrogen metabolism. Soy isoflavones, phytoestrogens found in soy foods, may modify the activity of these enzymes...
  14. ncbi Risks and benefits of dietary isoflavones for cancer
    Susanne Andres
    Department of Food Safety, Federal Institute for Risk Assessment, Berlin, Germany
    Crit Rev Toxicol 41:463-506. 2011
    ..context, considerable attention is paid to Asian populations who consume high amounts of soy and soy-derived isoflavones, and have a lower risk for several cancer types such as breast and prostate cancers than populations in Western ..
  15. pmc Effects of the isoflavones genistein and equol on the gonadal development of Japanese medaka Oryzias latipes
    Yiannis Kiparissis
    Environmental and Resource Studies, Trent University, Peterborough, Ontario, Canada
    Environ Health Perspect 111:1158-63. 2003
    ..This laboratory study indicates that isoflavone compounds should be considered candidate estrogenic compounds that may be involved in the alteration of sexual development in feral fish populations...
  16. ncbi Soy isoflavones for osteoporosis: an evidence-based approach
    Kyoko Taku
    Section of Biostatistical Research, Center for International Collaboration and Partnership, National Institute of Health and Nutrition, Tokyo, Japan
    Maturitas 70:333-8. 2011
    Effects of soy isoflavones on osteoporosis remain unclear. This review aimed to clarify the effect of soy isoflavones on bone mineral density (BMD) and turnover markers in menopausal women...
  17. ncbi Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms: a randomized, double-blind trial
    Silvina Levis
    Geriatric Research, Education, and Clinical Center, Miami Veterans Affairs Healthcare System, USA
    Arch Intern Med 171:1363-9. 2011
    ..Our goal was to determine the efficacy of soy isoflavone tablets in preventing bone loss and menopausal symptoms...
  18. ncbi Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells
    Ying Ju Lin
    Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, Taiwan
    Biochem Biophys Res Commun 378:683-8. 2009
    ..In the present study, we investigated the effects of the PR isoflavones puerarin, daidzein, and genistein on the growth of breast cancer cells...
  19. ncbi Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies
    Jia Yi Dong
    Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow University, Suzhou, China
    Breast Cancer Res Treat 125:315-23. 2011
    ..We aimed to examine the association between soy isoflavones consumption and risk of breast cancer incidence or recurrence, by conducting a meta-analysis of prospective ..
  20. ncbi Legumes and soybeans: overview of their nutritional profiles and health effects
    M J Messina
    Nutrition Matters, Inc, Townsend, WA 98368, USA
    Am J Clin Nutr 70:439S-450S. 1999
    ..Soybeans are unique among the legumes because they are a concentrated source of isoflavones. Isoflavones have weak estrogenic properties and the isoflavone genistein influences signal transduction...
  21. ncbi A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy
    M G Glazier
    Department of Family Practice and Community Medicine, University of Pennsylvania, Second Floor, Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Arch Intern Med 161:1161-72. 2001
    ..Therefore, there is insufficient evidence to recommend the use of phytoestrogens in place of traditional ERT, or to make recommendations to women about specific phytoestrogen products...
  22. ncbi S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora
    Kenneth D R Setchell
    Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children s Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati 45229, OH, USA
    Am J Clin Nutr 81:1072-9. 2005
    ..Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers.
  23. pmc Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells
    Yiwei Li
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 283:27707-16. 2008
    ..In conclusion, our data suggest that isoflavone could be useful for the prevention and/or treatment of PCa...
  24. ncbi Clinical pharmacology of isoflavones and its relevance for potential prevention of prostate cancer
    Paul L de Souza
    St George Hospital Clinical School, UNSW, Kogarah, New South Wales, Australia
    Nutr Rev 68:542-55. 2010
    b>Isoflavones are phytoestrogens that have pleiotropic effects in a wide variety of cancer cell lines...
  25. ncbi Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials
    Kyoko Taku
    Information Center and the Nutritional Education Program, National Institute of Health and Nutrition, Tokyo, Japan
    Am J Clin Nutr 85:1148-56. 2007
    ..Clinical trials have reported the cholesterol-lowering effects of soy protein intake, but the components responsible are not known...
  26. ncbi Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial
    Yuko Tousen
    Food Function and Labeling Program, National Institute of Health and Nutrition, Tokyo, Japan
    Menopause 18:563-74. 2011
    Equol is a metabolite of the isoflavone daidzein and may play a critical role in preventing bone loss by soy isoflavones in postmenopausal women. However, results from clinical trials have not been published...
  27. ncbi Metabolomics revealed novel isoflavones and optimal cultivation time of Cordyceps militaris fermentation
    Jung Nam Choi
    Department of Bioscience and Biotechnology and Bio Molecular Informatics Center, Konkuk University, Seoul, Republic of Korea
    J Agric Food Chem 58:4258-67. 2010
    ..OPLS-DA) of GSC clearly showed higher levels of soyasaponin Bd, soyasaponin Bc(II), daidzein, genistein, four isoflavones (compounds 1-4), glycerol, proline, glutamine, pentitol, fructose, inositol, octadecanoic acid, and sucrose ..
  28. ncbi Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine
    Kimiko Minamida
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Sapporo, Hokkaido, Japan
    J Biosci Bioeng 102:247-50. 2006
    b>Isoflavones (mainly daidzein and genistin) belong to the flavonoid group of compounds and are classified as phytoestrogens...
  29. ncbi Isoflavones stimulate estrogen receptor-mediated core histone acetylation
    Tao Hong
    Department of Biochemistry, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Biochem Biophys Res Commun 317:259-64. 2004
    The isoflavones genistein and daidzein and the daidzein metabolite equol have been reported to interact with estrogen receptors (ERs). Some studies indicate that they behave clinically like estrogen in some estrogen-deficiency diseases...
  30. ncbi Phyto-oestrogens and cancer
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
    Lancet Oncol 3:364-73. 2002
    ..This review includes a discussion of the consumption of phyto-oestrogen-rich foods such as soy, a source of isoflavones, and whole grain products, which contain lignans, and their role in the prevention of breast, prostate, and ..
  31. ncbi Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status
    Y A Cho
    Cancer Epidemiology Branch, Division of Cancer Epidemiology and Management, Research Institute, National Cancer Center, Gyeonggi Do, South Korea
    Eur J Clin Nutr 64:924-32. 2010
    ..Although high soy consumption may be associated with lower breast cancer risk in Asian populations, findings from epidemiological studies have been inconsistent...
  32. pmc Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women
    Wenyi Qin
    Department of Surgery, University of Missouri School of Medicine Columbia, One Hospital Drive, Columbia, MO 65212, USA
    Nutr Cancer 61:238-44. 2009
    We determined if soy isoflavones have dose-related estrogenic and methylation effects. Thirty-four healthy premenopausal women were randomized to 40 mg or 140 mg isoflavones daily through one menstrual cycle...
  33. ncbi Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling
    Biju Bhargavan
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, Lucknow, Uttar Pradesh, India
    J Cell Biochem 108:388-99. 2009
    ..To the best of our knowledge, this work represents the first attempt to elucidate structure-activity relationship between the two methoxylated isoflavones regarding their effects in osteoblasts and bone formation.
  34. ncbi Dietary phytoestrogens and breast cancer risk
    Lital Keinan-Boker
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands
    Am J Clin Nutr 79:282-8. 2004
    A high intake of phytoestrogens, particularly isoflavones, has been suggested to decrease breast cancer risk. Results from human studies are inconclusive.
  35. ncbi Cloning, expression and characterization of CYP102D1, a self-sufficient P450 monooxygenase from Streptomyces avermitilis
    Kwon Young Choi
    School of Chemical and Biological Engineering, Institute of Bioengineering, Seoul National University, Seoul, South Korea
    FEBS J 279:1650-62. 2012
    ..Interestingly, replacement of F96V/M246I in the active site increased catalytic activity for daidzein with a k(cat)/K(m) value of 100.9 ± 10.4 μM(-1)·min(-1) (15-fold)...
  36. ncbi Antioxidant activity of isoflavones and their major metabolites using different in vitro assays
    Corinna E Rüfer
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition and Food, Haid und Neu Strasse 9, 76131 Karlsruhe, Germany
    J Agric Food Chem 54:2926-31. 2006
    ..Genistein and daidzein, the major isoflavones found in soy, have received the most attention...
  37. ncbi Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer
    Vinita Singh-Gupta
    Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Thorac Oncol 6:688-98. 2011
    Soy isoflavones sensitize cancer cells to radiation both in vitro and in vivo. To improve the effect of radiotherapy for non-small cell lung cancer, we assessed the potential of using a complementary approach with soy isoflavones.
  38. ncbi Soy, isoflavones, and prostate cancer
    Le Jian
    School of Public Health, Health Innovation Research Institute, Curtin University of Technology, Kent Street, Bentley 6102, Perth, Australia
    Mol Nutr Food Res 53:217-26. 2009
    ..Soybean is a species of legume contain high amount of isoflavones including genistein, daidzein, glycitein, and equol, which have a prophylactic effect on prostate cancer...
  39. ncbi Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 900, Seattle, WA 98109, USA
    J Nutr 131:740-4. 2001
    ..These results suggest that a daily 16 g-fiber dose as wheat bran and the addition of soy protein do not alter significantly the capacity of colonic microflora to produce equol...
  40. pmc Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study
    Elisa V Bandera
    Cancer Prevention and Control Program Division of Surgical Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    BMC Womens Health 11:40. 2011
    ..While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention...
  41. pmc The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems
    Stephen Barnes
    Department of Pharmacology and Toxicology, MCLM 452, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA
    Food Funct 2:235-44. 2011
    ..Inflammatory cells produce chemical oxidants (HOCl, HOBr, ONO(2)(-)) that will react with polyphenols. The isoflavones daidzein and genistein and the flavonol quercetin form mono- and dichlorinated products in reaction with HOCl...
  42. ncbi Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence
    D M Tham
    Stanford Center for Research in Disease Prevention, Stanford University Medical School, California 94304, USA
    J Clin Endocrinol Metab 83:2223-35. 1998
    ..metabolic products have been identified in various human body fluids and fall under two main categories: isoflavones and lignans...
  43. ncbi Isoflavonoid photoprotection in mouse and human skin is dependent on metallothionein
    Sitarina Widyarini
    Faculty of Veterinary Science, University of Sydney, New South Wales, Australia
    J Invest Dermatol 126:198-204. 2006
    ..We speculate that equol and its related derivative NV-07alpha may activate the MT gene synergistically with SSUV, to produce the enhanced immunoprotective effect...
  44. ncbi Enhanced oral bioavailability of puerarin using microemulsion vehicle
    Hongfei Wu
    Department of Pharmaceutics, Anhui University of Traditional Chinese Medicine, Anhui Province Key Laboratory of R and D of Chinese Medicine, Hefei, P R China
    Drug Dev Ind Pharm 35:138-44. 2009
    ..Puerarin microemulsion also showed good stability. These studies showed that microemulsion system of puerarin might be promising vehicles for the peroral delivery of puerarin...
  45. ncbi Implications of phytoestrogen intake for breast cancer
    Christine Duffy
    Brown University Medical School, Brown University, Providence, RI, USA
    CA Cancer J Clin 57:260-77. 2007
    ..There is in vivo animal data suggesting the phytoestrogen genistein may interfere with the inhibitive effects of tamoxifen on breast cancer cell growth...
  46. ncbi Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons
    Lixia Zhao
    Department of Molecular Pharmacology and Toxicology and Neuroscience Program, Pharmaceutical Sciences Center, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Exp Biol Med (Maywood) 227:509-19. 2002
    ....
  47. ncbi Induction of apoptosis by puerarin in colon cancer HT-29 cells
    Zengli Yu
    School of Public Health, Zhengzhou University, Zhengzhou 450052, China
    Cancer Lett 238:53-60. 2006
    ..These findings indicate that puerarin may act as a chemopreventive and/or chemotherapeutic agent in colon cancer cells by reducing cell viability and inducing apoptosis...
  48. ncbi Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin
    Shuihua Zhang
    School of Pharmacy, East China University of Science and Technology, Mailbox 268, Shanghai 200237, China
    J Nutr Biochem 17:485-91. 2006
    ..Consequently, all these results showed that puerarin could effectively reverse chemical-induced liver fibrosis in experimental rats, via the recovery of hepatic injury as well as the induction of apoptosis in activated HSC...
  49. ncbi Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial
    Jian Wu
    Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan
    Menopause 14:866-74. 2007
    ..This study aimed to investigate whether the effects of soy isoflavones on bone and fat mass are related to an individual's equol status.
  50. ncbi Modulation of soy isoflavones bioavailability and subsequent effects on bone health in ovariectomized rats: the case for equol
    J Mathey
    Groupe Osteoporose, U3M, INRA Theix, Saint Genes Champanelle, France
    Osteoporos Int 18:671-9. 2007
    ..Because equol, the main metabolite from soy isoflavones, is thought to be powerful, the present study was designated to evaluate the bone-sparing effects of equol by ..
  51. pmc Effect of an isoflavones-containing red clover preparation and alkaline supplementation on bone metabolism in ovariectomized rats
    S Kawakita
    Biokenkyusho Research Laboratory, Shizuoka, Japan
    Clin Interv Aging 4:91-100. 2009
    ..was to test the combined effect of a quality-controlled red clover extract (RCE) standardized to contain 40% isoflavones by weight (genistein, daidzein, biochanin A, and formononetin present as hydrolyzed aglycones) together with a ..
  52. pmc The soy isoflavones for reducing bone loss study: 3-yr effects on pQCT bone mineral density and strength measures in postmenopausal women
    Kristine M Shedd-Wise
    Nutrition Department, University of California, Davis, CA 95616, USA
    J Clin Densitom 14:47-57. 2011
    Soy isoflavones exert inconsistent bone density-preserving effects, but the bone strength-preserving effects in humans are unknown...
  53. ncbi Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones
    Giovanni E Mann
    Cardiovascular Division, School of Medicine, King s College London, 150 Stamford Street, London SE1 9NH, United Kingdom
    Curr Opin Pharmacol 9:139-45. 2009
    ..Although epidemiological evidence suggests that diets containing plant-derived isoflavones (phytoestrogens) afford protection against CVDs, supplementation trials have largely reported only marginal ..
  54. ncbi Soy, phytoestrogens and metabolism: A review
    Christopher R Cederroth
    Department of Genetic Medicine and Development, University of Geneva Medical School, Switzerland
    Mol Cell Endocrinol 304:30-42. 2009
    Of any plant, soy contains the largest concentration of isoflavones, a class of phytoestrogens. Phytoestrogens are structurally similar to estradiol and mimic its effects...
  55. ncbi The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies
    Christopher K Taylor
    Primus Pharmaceuticals, Inc, Scottsdale, Arizona 85201, USA
    Nutr Rev 67:398-415. 2009
    ..and supplements in the American diet has raised concerns about the possible estrogen-like effects of natural isoflavones and possible promotion or propagation of estrogen-sensitive cancers...
  56. ncbi Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats
    L Wu
    College of Pharmaceutical Sciences, Zhejiang University, Zijingang Campus of Zhejiang University, Hangzhou 310058, China
    Phytomedicine 14:652-8. 2007
    ....
  57. pmc Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials
    Lee Hooper
    SRD Senior Lecturer in Research Synthesis and Nutrition, School of Medicine, University of East Anglia, Health Policy and Practice, Norwich NR4 7TJ, Norfolk, UK
    Hum Reprod Update 16:745-60. 2010
    b>Isoflavones from soy and red clover exert modest hormonal effects in women, but the relevance to risk of breast cancer is unclear...
  58. pmc Equol: history, chemistry, and formation
    Kenneth D R Setchell
    Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Nutr 140:1355S-62S. 2010
    ..isolated from equine urine in 1932 and identified 50 years later in human urine as a metabolite of the soy isoflavones, daidzin and daidzein, is produced by intestinal bacteria in some, but not all, adults...
  59. ncbi Soy isoflavones augment the effect of TRAIL-mediated apoptotic death in prostate cancer cells
    Ewelina Szliszka
    Department of Microbiology and Immunology, Medical University of Silesia in Katowice, 41 808 Zabrze, Poland
    Oncol Rep 26:533-41. 2011
    ..Genistein, daidzein and equol, the predominant soy isoflavones, have been reported to lower the risk of prostate cancer...
  60. ncbi Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties
    Tina T X Dong
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China
    J Agric Food Chem 54:2767-74. 2006
    ..The current results support the ancient formulation of DBT, and the identified chemicals could serve as markers for quality control of DBT...
  61. ncbi Dietary isoflavones and vascular protection: activation of cellular antioxidant defenses by SERMs or hormesis?
    Richard C M Siow
    Cardiovascular Division, British Heart Foundation Centre of Research Excellence, School of Medicine, King s College London, 150 Stamford Street, London SE1 9NH, UK
    Mol Aspects Med 31:468-77. 2010
    ..models and cultured cells have provided important and novel insights into the mechanisms by which dietary isoflavones afford protection against vascular dysfunction through the amelioration of oxidative modifications and ..
  62. pmc A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway
    Thong C Ma
    Burke Cornell Medical Research Institute, White Plains, New York 10605, USA
    J Neurosci 30:739-48. 2010
    ....
  63. ncbi Soy product and isoflavone intakes are associated with a lower risk of type 2 diabetes in overweight Japanese women
    Akiko Nanri
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo 162 8655, Japan
    J Nutr 140:580-6. 2010
    b>Isoflavones have been shown to improve glucose metabolism, but epidemiologic data are limited...
  64. ncbi Phytoestrogens: recent developments
    Paul Cos
    Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Planta Med 69:589-99. 2003
    ....
  65. ncbi Method of defining equol-producer status and its frequency among vegetarians
    Kenneth D R Setchell
    Sanitarium Development and Innovation, Cooranbong, NSW 2265, Australia
    J Nutr 136:2188-93. 2006
    ..S-equol) is a specific end-metabolite formed in the biotransformation of the dietary soy isoflavones daidzin and daidzein by intestinal bacteria...
  66. ncbi Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial
    Jian Wu
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    J Bone Miner Res 21:780-9. 2006
    ..The combined intervention of isoflavone intake and walking exercise over 1 year in postmenopausal Japanese women exhibited a trend for a greater effect on prevention of bone loss at the total hip and Ward's triangle regions...
  67. pmc The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women
    D Lee Alekel
    Nutrition and Wellness Research Center, Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50010 8281, USA
    Am J Clin Nutr 91:218-30. 2010
    Our previous study indicated that soy protein with isoflavones lessened lumbar spine bone loss in midlife women.
  68. pmc Gender-specific associations between soy and risk of hip fracture in the Singapore Chinese Health Study
    Woon Puay Koh
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Am J Epidemiol 170:901-9. 2009
    ..There was a statistically significant association of tofu equivalents, soy protein, and isoflavones with hip fracture risk among women but not among men...
  69. ncbi Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies
    Ye Won Hwang
    Graduate School of Public Health, Yonsei University, Seoul, Korea
    Nutr Cancer 61:598-606. 2009
    ..This systematic review suggests that soy food consumption could lower the risk of prostate cancer. This conclusion, however, should be interpreted with caution because various biases can affect the results of a meta-analysis...
  70. ncbi Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones
    K D Setchell
    Clinical Mass Spectrometry Center, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 68:1333S-1346S. 1998
    ..estrogens called phytoestrogens, and in the past decade there has been considerable interest in the role of isoflavones because of their relatively high concentrations in soy protein...
  71. ncbi Activation of endothelial nitric oxide synthase by dietary isoflavones: role of NO in Nrf2-mediated antioxidant gene expression
    Giovanni E Mann
    Cardiovascular Division, School of Medicine, King s College London, 150 Stamford Street, London SE1 9NH, UK
    Cardiovasc Res 75:261-74. 2007
    ..Research on the potential health benefits of soy isoflavones and other polyphenols contained in red wine, green and black tea and dark chocolate developed rapidly during ..
  72. pmc The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization
    Harriet M Kluger
    Department of Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Transl Med 5:6. 2007
    ..Targeting XIAP warrants additional investigation as a therapeutic approach for metastatic melanoma...
  73. ncbi Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy?
    V Beck
    Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190 Vienna, Austria
    J Steroid Biochem Mol Biol 94:499-518. 2005
    ..Red clover and soy extracts contain isoflavones, which have a high affinity to estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), progesterone ..
  74. ncbi Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile
    Kirty S Solanky
    Biological Chemistry, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Anal Biochem 323:197-204. 2003
    ..Significant interest in the mechanisms of action of soy isoflavones has predominantly stemmed from in vitro experiments but to date the availability of analytical tools for ..
  75. ncbi Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women
    Liwei Gu
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    J Nutr 136:1215-21. 2006
    Various physiologic effects of soy food consumption have been attributed to the estrogenic actions of isoflavones. The order of estrogen receptor binding potency of soy-derived isoflavone aglycones is equol > genistein > daidzein, and ..
  76. ncbi Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Am J Clin Nutr 81:230S-242S. 2005
    ..3% to 43% of the ingested dose, depending on the polyphenol. Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with ..
  77. ncbi Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells
    M Maggiolini
    Department of Pharmaco-Biology, University of Calabria, Rende-Cosenza, Italy
    Mol Pharmacol 60:595-602. 2001
    ..Thus, the mode of action of phytoestrogens and the balance between being risk or chemopreventive factors for breast cancer may depend on the dietary load...
  78. ncbi Combined effect of soy isoflavones and vitamin D3 on bone loss in ovariectomized rats
    Kee Lung Chang
    Department of Biochemistry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Nutrition 29:250-7. 2013
    Several studies have shown that soy isoflavones have estrogen-like activities and might constitute an alternative to hormone replacement treatment...
  79. ncbi Advanced separation methods of food anthocyanins, isoflavones and flavanols
    Josep Valls
    Shirota Functional Foods SL, Reus, Spain
    J Chromatogr A 1216:7143-72. 2009
    ..The main subgroups are anthocyanins, catechins, isoflavones, flavonols and flavones...
  80. ncbi Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo
    Jian Chen
    Department of Pharmacology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China
    Cancer Lett 308:144-51. 2011
    ..This study demonstrated that at relatively low concentrations calycosin had stimulatory effects on the proliferation of MCF-7 cells, and we conclude that this is due to its estrogenic effect...
  81. pmc Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy
    Xinmei Kang
    Department of Medical Oncology, Cancer Hospital of Harbin Medical University, Harbin, China
    CMAJ 182:1857-62. 2010
    The intake of soy isoflavones among women with breast cancer has become a public health concern, because these compounds have weak estrogenic effects...
  82. ncbi Polymorphic catechol-O-methyltransferase gene, soy isoflavone intake and breast cancer in postmenopausal women: a case-control study
    Qiong Wang
    Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610041, PR China
    Chin J Cancer 29:683-8. 2010
    ..Soy isoflavones possesses chemical structure similar to endogenous estrogen and may promote the carcinogenesis of breast cancer...
  83. ncbi Biphasic positive effect of formononetin on metabolic activity of human normal and osteoarthritic subchondral osteoblasts
    Jeong Eun Huh
    Oriental Medicine Research Center for Bone and Joint Disease, Kyunghee University, 149, Sangil dong, Kangdong gu, Seoul, 134 727, Republic of Korea
    Int Immunopharmacol 10:500-7. 2010
    ..Taken together, these results could suggest that formononetin has biphasic positive effects on normal Obs and OA Obs by modifying their biological synthetic capacities...
  84. pmc Clinical outcomes of a 2-y soy isoflavone supplementation in menopausal women
    Francene M Steinberg
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 93:356-67. 2011
    Soy isoflavones are naturally occurring phytochemicals with weak estrogenic cellular effects. Despite numerous clinical trials of short-term isoflavone supplementation, there is a paucity of data regarding longer-term outcomes and safety.
  85. ncbi Puerarin exhibits weak estrogenic activity in female rats
    Suchinda Malaivijitnond
    Primate Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Fitoterapia 81:569-76. 2010
    ..0mg/kg BW/day of puerarin for 140 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the number of uterine glands, but a significant increase in the %Co was observed from day 98 onwards...
  86. ncbi Protective actions of soy isoflavones and n-3 PUFAs on bone mass in ovariectomized rats
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907 2009, USA
    J Nutr Biochem 16:479-88. 2005
    ..This research examined the combined effects of two levels of soy isoflavones (IFs), trace (-IF) and high (+IF) (0.03 and 3...
  87. pmc Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells
    Vinita Singh-Gupta
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI
    Int J Cancer 124:1675-84. 2009
    We previously showed that treatment of prostate cancer cells with soy isoflavones and radiation resulted in greater cell killing in vitro, and caused downregulation of NF-kappaB and APE1/Ref-1...
  88. ncbi Soy product and isoflavone intake and breast cancer risk defined by hormone receptor status
    Caixia Zhang
    Centre of Research and Promotion of Women s Health, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong
    Cancer Sci 101:501-7. 2010
    ..This study suggests that consumption of soy food, soy isoflavone, is inversely associated with the risk of breast cancer. The protective effects of soy did not seem to differ by ER and PR breast cancer status...
  89. ncbi Signaling mechanisms of daidzein-induced axonal outgrowth in hippocampal neurons
    Pei Wang
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10051, Taiwan
    Biochem Biophys Res Commun 366:393-400. 2008
    ..Taken together, our data suggest that Dz triggers an ERbeta/PKCalpha/GAP-43 signaling cascade to promote axonal outgrowths in cultured hippocampal neurons...
  90. ncbi Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis
    Lin Yan
    Grand Forks Human Nutrition Research Center, ARS, USDA, Grand Forks, ND 58202 9034, USA
    Am J Clin Nutr 89:1155-63. 2009
    ..Epidemiologic studies have shown that the consumption of soy foods may be associated with a reduction in cancer risk in humans...
  91. ncbi Comparisons of percent equol producers between prostate cancer patients and controls: case-controlled studies of isoflavones in Japanese, Korean and American residents
    Hideyuki Akaza
    Department of Urology, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Jpn J Clin Oncol 34:86-9. 2004
    ....
  92. ncbi Phytoestrogenic isoflavones daidzein and genistein reduce glucose-toxicity-induced cardiac contractile dysfunction in ventricular myocytes
    Kadon K Hintz
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, North Dakota, USA
    Endocr Res 30:215-23. 2004
    ..In the present study, we examined the effect of phytoestrogenic isoflavones daidzein and genistein on glucose toxicity-induced cardiac mechanical malfunction simulating diabetic ..
  93. ncbi Crystal structure of isoflavone reductase from alfalfa (Medicago sativa L.)
    Xiaoqiang Wang
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    J Mol Biol 358:1341-52. 2006
    ..Isoflavone reductase (IFR) specifically recognizes isoflavones and catalyzes a stereospecific NADPH-dependent reduction to (3R)-isoflavanone...
  94. ncbi Receptor binding and transactivation activities of red clover isoflavones and their metabolites
    Angelika Pfitscher
    Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    J Steroid Biochem Mol Biol 112:87-94. 2008
    Red clover extracts contain a variety of isoflavones, which have affinity toward estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), androgen receptor (AR), and progesterone receptor (PR)...
  95. ncbi Hydrogen peroxide-induced apoptosis in pc12 cells and the protective effect of puerarin
    B Jiang
    Department of Biochemical Engineering, Dalian University of Technology, 116024, China
    Cell Biol Int 27:1025-31. 2003
    ..It can block apoptosis in its early stages via the regulation of anti- and pro-apoptotic proteins, as well as by the attenuation of caspase-3 activation in H(2)O(2)-induced PC12 cells...
  96. ncbi Signaling networks from Gbeta1 subunit to transcription factors and actin remodeling via a membrane-located ERbeta-related protein in the rapid action of daidzein in osteoblasts
    Anne De Wilde
    The Institut National de la Recherche Agronomique, Laboratoire de Nutrition et de Santé Alimentaire, 78350 Jouy en Josas, France
    J Cell Physiol 209:786-801. 2006
    ....
  97. ncbi Review of the factors affecting bioavailability of soy isoflavones in humans
    Inge Lise Finné Nielsen
    Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
    Nutr Cancer 57:1-10. 2007
    Soy isoflavones have anticarcinogenic, antioxidant, and antiatherosclerotic activities. They also interact with the estrogen receptor, which makes them weak or moderate phytoestrogens...
  98. ncbi Effects of isoflavones equol and genistein on bone quality in a rat osteopenia model
    S Sehmisch
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Goettingen, Germany
    Phytother Res 24:S168-74. 2010
    ..Treatment with phytoestrogens induced improved bone quality. EQO and GEN might be alternatives for hormone replacement therapy, although further studies are needed to elucidate possible side effects...
  99. ncbi Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma
    Zhao Seng Bao
    Taizhou University School of Medicine, Jiaojiang 371000, China
    Int Immunopharmacol 11:899-906. 2011
    Epidemiologic studies have associated higher dietary consumption of soy isoflavones with decreased self-report of cough and allergic respiratory symptoms, but the pharmacodynamic effects of soy isoflavone on asthmatic model have not been ..
  100. ncbi Cardioprotective effect of sulphonated formononetin on acute myocardial infarction in rats
    Shumin Zhang
    College of Life Science, Ocean University of China, Qingdao, China
    Basic Clin Pharmacol Toxicol 108:390-5. 2011
    ....
  101. ncbi Enhanced oral bioavailability of daidzein by self-microemulsifying drug delivery system
    Qi Shen
    School of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, China
    Chem Pharm Bull (Tokyo) 58:639-43. 2010
    ..Relative bioavailability of SMEDDS was enhanced about 2.5-fold compared with that of the control group. The data suggest that the use of SMEDDS provide a potential way of daidzein administered orally...

Research Grants67

  1. Dietary Isoflavones, Tamoxifen, and Tumor Growth
    William Helferich; Fiscal Year: 2005
    ..This "self-medication" with dietary estrogenic isoflavones for relief of menopausal and TAM-associated menopause-like symptoms is often done without their physician's ..
  2. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Soy isoflavones possess estrogenic properties, and reproductive tract tissues (including Leydig cells) express estrogen receptors (ER1 and ER2)...
  3. Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention
    EDWIN DOUGLAS LEPHART; Fiscal Year: 2010
    ..Recent data demonstrate that high selenium (Se) intake or status and high intake of phytoestrogens (isoflavones) each provide a protective effect against prostate cancer, and that their combined use may provide greater ..
  4. Soy isoflavones to augment radiotherapy of lung carcinoma
    Gilda G Hillman; Fiscal Year: 2012
    ..normal lung included in the treatment plan, and yet increase radiation effect in the tumor target, using soy isoflavones. Mixtures of natural soy isoflavones containing genistein, daidzein and glycitein can sensitize cancer cells to ..
  5. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2011
    ..The basis for this correlation may be the presence of estrogen-like isoflavones (genistein and daidzein), in their diet...
  6. Plant-based diets and risk of cancer
    Gary E Fraser; Fiscal Year: 2013
    ..that differ between these dietary patterns, including red meat, tomatoes, dairy foods, cruciferous vegetables, isoflavones, long-chain fatty acids, and others...
  7. Bacterial and Chemical Carcinogens in Gastric Oncogenesis
    D Scott Merrell; Fiscal Year: 2012
    ..pylori infection and/or administration of a dietary carcinogen will be exposed to an isoflavones-depleted diet and the gastric mucosa will be studied for precancerous and neoplasitc transformation This ..
  8. Study of Soy Isoflavones in Asthma (SOYA)
    Lewis J Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This is the application for the Lead Clinical Center for the Study of Soy Isoflavones in Asthma (SOYA). It is linked to the Data Coordinating Center (DCC) application submitted by Dr...
  9. Study of Soy Isoflavones in Asthma (SOYA)
    Robert A Wise; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This is the application for the Lead Clinical Center for the Study of Soy Isoflavones in Asthma (SOYA). It is linked to the Data Coordinating Center (DCC) application submitted by Dr...
  10. Urinary peptide excretion and onset of puberty
    Stephen Barnes; Fiscal Year: 2009
    ..The effects of dietary intake of soy isoflavones and of race/ethnicity on the peptide markers will also be examined.
  11. Interaction of BPA and soy isoflavones on sociosexual behavior
    Heather B Patisaul; Fiscal Year: 2013
    ..adverse behavioral effects do not manifest in Wistar rats maintained on a soy-rich diet, suggesting that soy isoflavones, such as genistein (GEN) have potentially counteracting effects...
  12. Dietary and serum phytoestrogens and women's health conditions in midlife
    Gail A Greendale; Fiscal Year: 2012
    ..Stored serum, from the 3 same time points as the FFQs, will be assayed for selected isoflavones &metabolites...
  13. Chemo-dietary prevention, miRNAs, epigenetic and prostate cancer
    Rajvir Dahiya; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The main goal of this project is to investigate whether dietary isoflavones such as genistein can inhibit prostate cancer growth through activation of tumor suppressor microRNAs (miRNAs) using both ..
  14. Modulation of antitumor immunity by dietary soy and its isoflavone constituents
    Gregory B Lesinski; Fiscal Year: 2013
    ..Soy isoflavones are hypothesized to act through various pathways to impact prostate cancer (PCa) progression;however, one area ..
  15. BOTANICAL CENTER FOR AGE-RELATED DISEASES
    Connie M Weaver; Fiscal Year: 2010
    Several types of botanical products containing isoflavones are being marketed as an alternative to estrogen replacement therapy to prevent osteoporosis in postmenopausal women...
  16. ADJUVANT TRIAL WITH SOY AFTER RADICAL PROSTATECTOMY
    Maarten C Bosland; Fiscal Year: 2010
    ..The dose is 20 g protein/day (-22-26 mg/day genistein and -38-42 mg/day total isoflavones). Preliminary results indicate that this treatment is extremely safe...
  17. HIV/COCAINE NEUROTOXICITY IN FEMALES
    Rosemarie M Booze; Fiscal Year: 2013
    ..The ability of estrogen/soy isoflavones+ cocaine to produce DAT dysfunction/protection under physiological conditions will be assessed and the ..
  18. Effects of herbs on transcription and cell proliferation
    Dale Leitman; Fiscal Year: 2003
    ..the risk of breast cancer, whereas phytoestrogens might decrease the risk of breast cancer? Our studies with isoflavones suggest that the divergent action of estrogens and phytoestrogens on breast cells may result from differences ..
  19. Soy Almond Bread as Complimentary Therapy for Prostate Cancer
    Yael Vodovotz; Fiscal Year: 2010
    ..Our team of investigators have formulated two such systems: (a) a soy bread providing 33 mg isoflavones per 50g slice, and (b) 2-glucosidase-enriched soy bread that increases by 100% the aglycone form (potentially ..
  20. Estrogen Receptor-beta phytoSERMs for Management of Menopause and Memory Decline
    Lon S Schneider; Fiscal Year: 2012
    ..Because soy derived isoflavones sold as dietary supplements were not subject to formal drug development, and that this is a new combination of ..
  21. Novel Combinations of Foods Targeting Prostate Cancer Prevention
    KRYSTLE ERIN ZUNIGA; Fiscal Year: 2012
    ..In parallel, we will investigate the bioavailability of tomato carotenoids and soy isoflavones when tomato and soy germ are consumed together...
  22. Cardioprotective Effects of Dietary Flavonoids in the Framingham Offspring Cohort
    Paul Jacques; Fiscal Year: 2009
    ..the associations between five classes of dietary flavonoids (flavanols, anthocyanins, flavones, flavonols, and isoflavones) and the following CVD risk factors: inflammatory markers including C-reactive protein, interleukin 6, monocyte ..
  23. Effects of dietary soy compounds on stroke outcomes
    JOSEPH LATON CHEATWOOD; Fiscal Year: 2011
    ..the potential benefits and mechanism of action in the post-stroke brain of animals fed diets containing soy isoflavones and/or soy protein isolate...
  24. Molecular targets of soy isoflavones in breast cancer progression
    Suranganie F Dharmawardhane; Fiscal Year: 2011
    ..The RATIONALE is that soy isoflavones can affect cancer progression by antioxidant, estrogenic/antiestrogenic, antiangiogenic, and other inhibitory ..
  25. Molecular Mechanisms and Targets of Soy Compounds in the Prevention of Colon Canc
    Zigang Dong; Fiscal Year: 2013
    ..Numerous observational studies in humans have indicated that a high consumption of isoflavones or soy in certain countries is associated with a reduced risk of colon cancer...
  26. Taste psychophysics of bitter phytochemicals
    MIRIAM LINSCHOTEN; Fiscal Year: 2005
    ..Phytochemicals such as phenols, flavonoids, isoflavones, terpenes and glucosinolates have anti-oxidant and anti-carcinogenic properties and demonstrate a wide spectrum ..
  27. ANALYSIS AND PHYSIOLOGY OF ISOFLAVONES IN SOYBEANS
    Kenneth Setchell; Fiscal Year: 1993
    ..This proposal seeks to clarify our understanding of the absorption, metabolism and physiology of soy isoflavones in humans...
  28. PHYTOESTROGENS, ORGANOCHLORINES, AND FIBROID RISK
    Stephen Schwartz; Fiscal Year: 1999
    Phytoestrogens (such as isoflavones and lignans) and organochlorine compounds (such as pesticides and polychlorinated biphenyls) are two broad classes of putative endocnne disruptors -- chemicals that may have the capability to alter a ..
  29. Interactions Between Dietary Soy Components & Tamoxifen
    Jin Rong Zhou; Fiscal Year: 2003
    ..Soy phytochemicals, especially soy isoflavones, have anti-tumor activities...
  30. ISOFLAVONE TREATMENT FOR ALCOHOL ABUSE
    Scott E Lukas; Fiscal Year: 2011
    ..the preparation and have prepared an extract that contains a higher (and precise) concentration of the active isoflavones found in the original plant...
  31. Variations in plasma phytoestrogen levels in Europe
    Petra Peeters; Fiscal Year: 2004
    ..Their main two subclasses are isoflavones (soy and soy products) and lignans (whole grains, fruit and vegetables)...
  32. Absorption and Metabolism of Isoflavones
    Ming Hu; Fiscal Year: 2005
    ..Despite its proven in vitro anticancer activity, genistein and other isoflavones have poor bioavailability...
  33. A Molecular Basis for Phytoestrogen Chemoprevention
    Andrew Mesecar; Fiscal Year: 2002
    ..Four of the major phytoestrogen compounds in soy and red clover are the isoflavones genistein, daidzen, biochanin-A and formononetin...
  34. Soy Isoflavone Distribution in Biological Fluids as Markers of Prostate Exposure
    MINDY KURZER; Fiscal Year: 2007
    ..The soy components thought to be responsible for this effect are the isoflavones. As a result, soy isoflavones are currently being investigated in epidemiological and clinical studies for ..
  35. RED CLOVER PHYTOESTROGENS EFFECTS ON ATHEROSCLEROSIS
    James Goodrich; Fiscal Year: 1999
    ..Plant estrogens, also termed isoflavones or phytoestrogens found in legumes such as soybeans and red clover are a natural alternative which may have ..
  36. CHEMOPREVENTION OF MAMMARY TUMORS BY TAMOXIFEN AND SOY
    Andreas Constantinou; Fiscal Year: 2002
    Tamoxifen as an ERalpha antagonist is an effective chemopreventive agent against breast cancer. The soy isoflavones genistein and daidzein are ER (alpha and beta) agonists and antagonists...
  37. SOYBEANS AND CALCIUM METABOLISM IN POSTMENOPAUSAL WOMEN
    ELAINE LIPSCOMB; Fiscal Year: 1999
    ..Soybeans and their products are the principal source of the isoflavones, genistein and daidzein...
  38. EFFECT OF SOYBEANS ON BONE AND THE REPRODUCTIVE TRACT
    JANICE BAHR; Fiscal Year: 2002
    ..bone loss by slowing resorption and enhancing bone formation due to organ-selective estrogenic effects of the isoflavones genistein and daidzein. The applicant proposes four questions: 1...
  39. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..The therapeutic potential of phytoestrogens in MS, has yet to be studied. Isoflavones derived from soybeans are a rich source of phytoestrogens...
  40. ISOFLAVONE-RICH PASTA--CLINICAL AND COMMERCIAL POTENTIAL
    RICHARDUS ROSS; Fiscal Year: 2000
    ..Substantial evidence now exists implicating dietary soybean isoflavones as beneficial homone-modulators responsible for reducing the risk factors for these diseases...
  41. THE YUCATAN MICROPIG CARDIOVASCULAR MODEL OF MENOPAUSE
    James Goodrich; Fiscal Year: 2006
    ..e. soy protein/isoflavones)...
  42. PHASE II TRIAL OF SOY PRIOR TO RADICAL PROSTATECTOMY
    Maarten Bosland; Fiscal Year: 2007
    ..preparations are identical in composition except for the source of protein and soy-specific compounds such as isoflavones including genistein...
  43. Selenium, Isoflavones, Androgen Metabolism and Prostate Cancer Risk Reduction
    MERRILL CHRISTENSEN; Fiscal Year: 2009
    ..Nevertheless, the proposed research is seen as potentially important with a high probability for it being successful. ..
  44. PLANNING A HAWAII/JAPAN MAMMOGRAPHIC DENSITY STUDY
    Gertraud Maskarinec; Fiscal Year: 2000
    ..Regular intake of soy, macro- and micronutrients including isoflavones will be estimated using a nutritional data base. Mammograms for all study participants will be sent to Hawaii...
  45. Effect of soy isoflavone on cholesterol & SREBP-regulated gene expression.
    Eimear Mullen; Fiscal Year: 2009
    ..It is also unknown whether soy protein containing endogenous isoflavones would have the same effect as soy protein containing low isoflavones with isoflavones supplemented back to the ..
  46. DIETARY SOY EFFECTS ON MARKERS OF PROSTATE CANCER
    W Lee; Fiscal Year: 2000
    ..Soybeans and related legumes contain large quantities of plant estrogens known as isoflavones. Specific isoflavones found in soybeans (genistein, daidzein) have cancer protective properties...
  47. NUTRITION ACADEMIC AWARD
    Robert Knopp; Fiscal Year: 2002
    ..omega-3 fatty acids, antioxidant vitamins, vitamins bearing on homocysteine levels, other antioxidants such as isoflavones and carotenoids, plant estrogens, soya, salt, trace minerals and alcohol...
  48. Interaction Between Irinotecan and Dietary Flavonoids
    Lalitha Iyer; Fiscal Year: 2004
    ..The specific aims are to (1) investigate the in vivo interaction of soy isoflavones, chrysin and quercetin with irinotecan in rats, (2) determine whether hepatic UGT1A1 induction by flavonoids is ..
  49. PHYTOESTROGEN EFFECT ON POSTMENOPAUSAL ENDOMETRIUM
    Judith Balk; Fiscal Year: 1999
    ..Asian populations eat large amounts of soy products containing the phytoestrogens isoflavones, and have a lower incidence of osteoporosis, heart disease, breast cancer, as well as menopausal symptoms...
  50. ROLE OF CYTOCHROMES P450 IN ISOFLAVONE METABOLISM
    Elizabeth Roberts; Fiscal Year: 2001
    DESCRIPTION: (Verbatim from the Applicant's Abstract) The dietary isoflavones genistein, daidzein, formononetin, and biochanin A are derived from precursors primarily found in soybean products, bean sprouts and other legumes, and whole-..
  51. PHARMACOKINETICS OF SOYBEAN ANTICARCINOGENS
    LEE JANE LU; Fiscal Year: 1999
    ..will include 15-30 regularly cycling women who will be studied over 17 months as they ingest one dose of soya isoflavones (>200 mg) on separate months at seven specific periods during the menstrual cycle...
  52. UCLA CENTER FOR DIETARY SUPPLEMENTS RESEARCH: BOTANICALS
    David Heber; Fiscal Year: 2004
    ..John's Wort), four Pilot Studies (Echinacea, Flavonoids, Soy Isoflavones, and Plant Phytoestrogens, and three Scientific Cores in Agriculture and Botany, Analytic Phytochemistry, and ..
  53. Soy Isoflavones for Menopausal Vasomotor Symptoms
    Judith Ockene; Fiscal Year: 2006
    ..Soy isoflavones have been marketed for reducing VMS, but data are inconclusive as to their effectiveness...
  54. Antioxidant Interactions with Prostate Cancer Treatments
    Kathleen Shiverick; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The antioxidants vitamin E (VE) and soy isoflavones (ISF) have potential as important chemoprevention agents for prostate cancer (PCa) as single agents and in combination with commonly ..
  55. SOY ISOFLAVONES AND CELL PROLIFERATION
    Roberd Bostick; Fiscal Year: 2000
    ..non-human primates and has been designed to provide data to directly support subsequent clinical studies on soy isoflavones in humans...
  56. Urinary Phytoestrogen Excretion and Breast Cancer Risk
    Wei Zheng; Fiscal Year: 2001
    Phytoestrogens, primarily isoflavones and lignans, have been implicated strongly in animal and in vitro experiments as promising compounds against cancer, particularly breast and other hormone-related cancers...
  57. Isoflavones, equol producing status, and breast density in US Chinese women
    Carolyn Fang; Fiscal Year: 2009
    b>Isoflavones, phytoestrogens found primarily in soy foods, are thought to protect against breast cancer, but epidemiologic evidence for such an effect is inconsistent...
  58. CARDIOVASCULAR BENEFITS OF SOY PHYTOESTROGENS
    JAY KAPLAN; Fiscal Year: 2004
    ..What is the peptide fraction of soy protein that is required for the phytoestrogens (isoflavones) to have their effect on lipid metabolism? 2...
  59. QUANTITATION & BIOAVAILABILITY OF SOYFOOD ISOFLAVONES
    Patricia Murphy; Fiscal Year: 1992
    This research project plans to examine the amounts of the major soybean isoflavones in soy foods and determine their bioavailability in humans...
  60. Dev & Testing of New Medications for Treatment of Emerging Infectious Diseases
    Mitchell Avery; Fiscal Year: 2006
    ..We have nontoxic antigiardial derivatives of naturally occurring isoflavones that are being fine tuned for intestinal delivery, and are inexpensive to prepare...
  61. Soy Isoflavone Supplementation and Mammographic Density in Postmenopausal Women
    William Wong; Fiscal Year: 2007
    ..Soy foods, which contain high concentrations of isoflavones, might protect against breast cancer, but the potential preventive benefit of isoflavones against breast cancer ..
  62. Dietary Isoflavone Regulated Genes in Prostate Cancer
    Lori Rice; Fiscal Year: 2002
    ..Soy products are particularly rich in isoflavones, a class of naturally occurring phytoestrogens...
  63. Economical Soy-Isoflavone Production
    J Weber; Fiscal Year: 2001
    Commercial applications for soy isoflavones have grown significantly in recent years. This is fueled by research revealing the potential health benefits of diets containing soy products and increasing interest in functional foods...
  64. PHYTOESTROGENS AND COLON EPITHELIUM--A RANDOMIZED TRIAL
    Johanna Lampe; Fiscal Year: 2001
    ..Foods high in plant estrogens, (particularly soy isoflavones) are associated with reduced risk of colon neoplasia in epidemiologic studies...
  65. Soy Isoflavones on NO Production in Postmenopausal Women
    William Wong; Fiscal Year: 2003
    ..b>Isoflavones, which have chemical structures similar to estradiol but possess anti-cancer properties, are found in abundance ..
  66. MCF10DCIS.com as a preclinical chemopreventive screen
    Fred Miller; Fiscal Year: 2003
    ..being conducted at the Karmanos Cancer Institute in which patients diagnosed with DCIS are given 100 mg of soy isoflavones daily for three weeks prior to surgery...
  67. Genistein induces thymic atrophy: a health concern?
    Paul Cooke; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Relative consumption of the estrogenic soy isoflavones genistein and daidzein in infants fed soy-based formula is 10- fold greater than adults eating high-soy diets, and commercial rodent diets also ..