flavanones

Summary

Summary: A group of FLAVONOIDS characterized with a 4-ketone.

Top Publications

  1. ncbi Baicalein inhibits the migration and invasive properties of human hepatoma cells
    Yung Wei Chiu
    Emergency Department and Center of Hyperbaric Oxygen Therapy, Tungs Taichung Metroharbor Hospital, Taichung, Taiwan
    Toxicol Appl Pharmacol 255:316-26. 2011
  2. ncbi Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines
    S Chen
    Brander Cancer Research Institute, New York Medical College, Hawthorne, NY 10532, USA
    Cell Prolif 34:293-304. 2001
  3. ncbi Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice
    I Erlund
    Department of Nutrition, National Public Health Institute KTL, Mannerheimintie 166 F, FIN 00300 Helsinki, Finland
    J Nutr 131:235-41. 2001
  4. ncbi Baicalein and 12/15-lipoxygenase in the ischemic brain
    Klaus van Leyen
    Stroke and Neurovascular Research Group, Department of Radiology, Massachusetts General Hospital, 149 13th St, R 2401, Charlestown, MA 02129, USA
    Stroke 37:3014-8. 2006
  5. pmc The effects of the cyclosporin A, a P-glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study
    T H Tsai
    National Research Institute of Chinese Medicine, 115 1 Li Nong Street Section 2, Shih Pai, Taipei 112, Taiwan
    Br J Pharmacol 137:1314-20. 2002
  6. ncbi Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity
    Hua Zi Piao
    Department of Pharmacology, College of Medicine, Yanbian University, Yanji, China
    Int Immunopharmacol 8:1658-62. 2008
  7. ncbi Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells
    Syng Ook Lee
    Department of Food Science and Technology and The Center for Traditional Microorganism Resources TMR, Keimyung University, 1000 Sindang Dong, Dalseo Gu, Daegu 704 701, Republic of Korea
    Biochem Biophys Res Commun 351:118-25. 2006
  8. ncbi Binding aspects of baicalein to HIV-1 integrase
    H C Ahn
    Department of Pharmacy, Seoul National University, Korea
    Mol Cells 12:127-30. 2001
  9. pmc Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance
    Erin E Mulvihill
    Department of Vascular Biology, Robarts Research Institute, Ontario, Canada
    Diabetes 58:2198-210. 2009
  10. pmc Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist
    Jennifer E Mersereau
    Department of Obstetrics, Gynecology and Reproductive Sciences and Center for Reproductive Sciences, Cellular and Molecular Pharmacology, University of California, San Francisco, CA, United States
    Mol Cell Endocrinol 283:49-57. 2008

Research Grants

  1. Cardioprotective Effects of Dietary Flavonoids in the Framingham Offspring Cohort
    Paul Jacques; Fiscal Year: 2009
  2. Synthesis and Evaluation of Anti-Tumor Flavanoids
    ANTOINETTE EVADNEY NIBBS; Fiscal Year: 2011
  3. Synthesis of Anticancer Pyran Natural Products
    Karl A Scheidt; Fiscal Year: 2010
  4. CHALCONE ISOMERASE--MECHANISM OF CATALYSIS
    RODNEY BEDNAR; Fiscal Year: 1990
  5. ENDOCRINE DISRUPTING CHEMICALS AND AROMATASE
    Shiuan Chen; Fiscal Year: 2009
  6. Case-Control Study of Adenoma in Sao Paulo Japanese
    Loic Le Marchand; Fiscal Year: 2008
  7. Ethnic/Racial Minorities in the Colon CFR
    Loic Le Marchand; Fiscal Year: 2008
  8. Green Tea Targets COX-2/PGE2 and EFGR Pathways in NSCLC via Stimulating Annexin 1
    Qing Yi Lu; Fiscal Year: 2008
  9. MOLECULAR REGULATION OF THE HUMAN BRCA 1 GENE
    DONATO ROMAGNOLO; Fiscal Year: 2003
  10. PLANT ANTITUMOR AGENTS
    Kuo Hsiung Lee; Fiscal Year: 2009

Detail Information

Publications277 found, 100 shown here

  1. ncbi Baicalein inhibits the migration and invasive properties of human hepatoma cells
    Yung Wei Chiu
    Emergency Department and Center of Hyperbaric Oxygen Therapy, Tungs Taichung Metroharbor Hospital, Taichung, Taiwan
    Toxicol Appl Pharmacol 255:316-26. 2011
    ..These results demonstrate the anticancer properties of baicalein, which include the inhibition of adhesion, invasion, migration, and proliferation of human hepatoma cells in vivo...
  2. ncbi Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines
    S Chen
    Brander Cancer Research Institute, New York Medical College, Hawthorne, NY 10532, USA
    Cell Prolif 34:293-304. 2001
    ..Both agents (1) caused an apparent accumulation of cells in G(1) at the ED(50) concentration, (2) induced apoptosis at higher concentrations, and (3) decreased expression of the androgen receptor in LNCaP cells...
  3. ncbi Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice
    I Erlund
    Department of Nutrition, National Public Health Institute KTL, Mannerheimintie 166 F, FIN 00300 Helsinki, Finland
    J Nutr 131:235-41. 2001
    The flavanones naringenin and hesperetin exhibit estrogenic, anticarcinogenic and antioxidative properties...
  4. ncbi Baicalein and 12/15-lipoxygenase in the ischemic brain
    Klaus van Leyen
    Stroke and Neurovascular Research Group, Department of Radiology, Massachusetts General Hospital, 149 13th St, R 2401, Charlestown, MA 02129, USA
    Stroke 37:3014-8. 2006
    ..The current study was designed to test if the neuroprotective properties of baicalein are related to its lipoxygenase inhibition...
  5. pmc The effects of the cyclosporin A, a P-glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study
    T H Tsai
    National Research Institute of Chinese Medicine, 115 1 Li Nong Street Section 2, Shih Pai, Taipei 112, Taiwan
    Br J Pharmacol 137:1314-20. 2002
    ..6. Although no direct transport studies were undertaken and multiple factors may affect BBB penetration and hepatobiliary excretion, strong association of the involvement of P-glycoprotein in these processes is indicated...
  6. ncbi Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity
    Hua Zi Piao
    Department of Pharmacology, College of Medicine, Yanbian University, Yanji, China
    Int Immunopharmacol 8:1658-62. 2008
    ..Our results indicate that the anti-inflammatory activity of wogonin is exerted at least in part by suppressing microglial cell motility via inhibition of NF-kappaB activity...
  7. ncbi Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells
    Syng Ook Lee
    Department of Food Science and Technology and The Center for Traditional Microorganism Resources TMR, Keimyung University, 1000 Sindang Dong, Dalseo Gu, Daegu 704 701, Republic of Korea
    Biochem Biophys Res Commun 351:118-25. 2006
    ....
  8. ncbi Binding aspects of baicalein to HIV-1 integrase
    H C Ahn
    Department of Pharmacy, Seoul National University, Korea
    Mol Cells 12:127-30. 2001
    ..This binding of baicalein induces the conformational change of the enzyme. We also found that the binding ratio of baicalein to the HIV-1 integrase catalytic domain is 2:1...
  9. pmc Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance
    Erin E Mulvihill
    Department of Vascular Biology, Robarts Research Institute, Ontario, Canada
    Diabetes 58:2198-210. 2009
    ..We evaluated whether naringenin regulates lipoprotein production and insulin sensitivity in the context of insulin resistance in vivo...
  10. pmc Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist
    Jennifer E Mersereau
    Department of Obstetrics, Gynecology and Reproductive Sciences and Center for Reproductive Sciences, Cellular and Molecular Pharmacology, University of California, San Francisco, CA, United States
    Mol Cell Endocrinol 283:49-57. 2008
    ..In a mouse xenograph model, liquiritigenin did not stimulate uterine size or tumorigenesis of MCF-7 breast cancer cells. Our results demonstrate that some plants contain highly selective estrogens for ERbeta...
  11. ncbi Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes
    Ashok Kumar Sharma
    Department of Pharmacology, Cardiovascular and Diabetes Research Laboratory, All India Institute of Medical Sciences, New Delhi, India
    Br J Nutr 106:1713-23. 2011
    ....
  12. ncbi Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells
    Graham P Pidgeon
    Department of Radiation Oncology, Wayne State University, Detroit, Michigan 48202, USA
    Cancer Res 62:2721-7. 2002
    ..Therefore, inhibition of 12-LOX is a potential therapeutic agent in the treatment of prostate cancer...
  13. ncbi Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice
    Un Ju Jung
    Department of Food Science and Nutrition, Kyungpook National University, 1370 San Kyuk Dong Puk Ku, 702 701 Daegu, Republic of Korea
    Int J Biochem Cell Biol 38:1134-45. 2006
    ....
  14. ncbi Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes
    Jed W Fahey
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Agric Food Chem 50:7472-6. 2002
    ..110,000 units/g) is even higher than that of broccoli and the potencies of fingerroot oil and powdered rhizome (ca. 500,000 units/g) rival that of broccoli sprouts...
  15. ncbi The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats
    Li Li Shi
    National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China
    Life Sci 88:521-8. 2011
    ..The therapeutic effect of pinocembrin, together with the therapeutic time window, in the transient global cerebral ischemia/reperfusion (I/R) rats was investigated...
  16. ncbi Pinocembrin prevents glutamate-induced apoptosis in SH-SY5Y neuronal cells via decrease of bax/bcl-2 ratio
    Mei Gao
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Eur J Pharmacol 591:73-9. 2008
    ..Thus we conclude that pinocembrin exerts its neuroprotective effects in glutamate injury model partly by inhibiting p53 expression, thus Bax-Bcl-2 ratio, and the release of cytochrome c...
  17. ncbi Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet
    Peng Pu
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, PR China
    Arch Biochem Biophys 518:61-70. 2012
    ....
  18. ncbi Preparation and evaluation of self-microemulsifying drug delivery system of baicalein
    Wenli Liu
    School of Pharmacy, Chongqing Medical University, Chongqing 400016, China
    Fitoterapia 83:1532-9. 2012
    ..7% increase in relative bioavailability compared with that of the baicalein suspension. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds, such as baicalein by the oral route...
  19. pmc Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia
    Guang Jin
    Massachusetts General Hospital, Neuroprotection Research Laboratory, 149 13th Street, R 2401, Charlestown, MA 02129, USA
    Stroke 39:2538-43. 2008
    ..The current study was designed to investigate 12/15-LOX involvement in vascular injury in the ischemic brain...
  20. ncbi Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats
    Miao Ying Lai
    Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan 404, ROC
    J Pharm Pharmacol 55:205-9. 2003
    ....
  21. ncbi New flavanones from the leaves of Cryptocarya chinensis and their antituberculosis activity
    Tsung Hsien Chou
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Chem Biodivers 8:2015-24. 2011
    Four new flavanones, cryptoflavanones A-D (1-4, resp.), together with eight known compounds, were isolated from the leaves of Cryptocarya chinensis. The structures of these new compounds were determined by spectral analyses...
  22. ncbi Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside
    Araceli Sala
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Eur J Pharmacol 461:53-61. 2003
    ..As in the case of other flavonoids, the anti-inflammatory activity of tiliroside could be based on its antioxidant properties, although other mechanisms are probably involved...
  23. ncbi Naringenin attenuates mucous hypersecretion by modulating reactive oxygen species production and inhibiting NF-κB activity via EGFR-PI3K-Akt/ERK MAPKinase signaling in human airway epithelial cells
    J Yang
    Division of Respiratory Medicine, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
    Mol Cell Biochem 351:29-40. 2011
    ....
  24. pmc Baicalein--an intriguing therapeutic phytochemical in pancreatic cancer
    Graham Donald
    UCLA Center for Excellence in Pancreatic Diseases, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Curr Drug Targets 13:1772-6. 2012
    ..Compounds such as baicalein, offer promise in dietary chemoprevention, as chemotherapeutic adjuvants, or as targeted therapy...
  25. ncbi Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling
    Rong Rui Liang
    Department of General Surgery, Second Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an 710004, P R China
    Int J Oncol 41:969-78. 2012
    ..Consequently, these findings suggest that Baicalein preferentially inhibits HCC tumor growth through inhibition of MEK-ERK signaling and by inducing intrinsic apoptosis...
  26. ncbi Baicalein protects human melanocytes from H₂O₂-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway
    Bangmin Liu
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, China 710032
    Free Radic Biol Med 53:183-93. 2012
    ..The results demonstrate for the first time that BE exerts a cytoprotective role in H(2)O(2)-induced apoptosis by inhibiting the mitochondria-dependent caspase activation and p38 MAPK pathway...
  27. ncbi Inhibition of quorum sensing (QS) in Yersinia enterocolitica by an orange extract rich in glycosylated flavanones
    Pilar Truchado
    Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS CSIC, P O Box 164, 30100 Campus de Espinardo, Murcia, Spain
    J Agric Food Chem 60:8885-94. 2012
    b>Flavanones, flavonoids abundant in Citrus , have been shown to interfere with quorum sensing (QS) and affect related physiological processes...
  28. ncbi Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway
    Chao Liu
    Department of Pharmacology, Pharmaceutical College, Xianning University, Xianning, China
    J Neurochem 112:1500-12. 2010
    ..Together, these findings provide evidence that Bai protects neurons against ischemia injury and this neuroprotective effect involves PI3K/Akt and PTEN pathway...
  29. ncbi Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process
    Lise Madsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark
    Biochem J 375:539-49. 2003
    ..We suggest that endogenous PPARgamma ligand(s) promoting adipocyte differentiation are generated via a baicalein-sensitive pathway involving the novel eLOX-3...
  30. ncbi Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes
    P A Lapchak
    University of California, San Diego, Department of Neuroscience, La Jolla, CA 92093 0624, USA
    Neuroscience 150:585-91. 2007
    ..The results suggest that baicalein, or derivatives of baicalein with multiple pharmacological activities may be useful to develop as novel treatments for acute ischemic stroke...
  31. ncbi Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9
    Pu Chen
    Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People s Republic of China
    Toxicology 282:122-8. 2011
    ..These results suggested that wogonin could inhibit the invasion of tumor cells by downregulating the expression and activity of MMP-9, the possible targets may be PKCδ and ERK1/2...
  32. ncbi Inhibition of beta-catenin/Tcf signaling by flavonoids
    Seyeon Park
    Department of Applied Chemistry, Dongduk Women s University, Seoul 136 714, South Korea
    J Cell Biochem 110:1376-85. 2010
    ....
  33. ncbi Protections of pinocembrin on brain mitochondria contribute to cognitive improvement in chronic cerebral hypoperfused rats
    Hong Mei Guang
    National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No 1 Xian Nong Tan Street, Beijing 100050, PR, China
    Eur J Pharmacol 542:77-83. 2006
    ..Pinocembrin could improve rat cognitive impairments induced by chronic cerebral hypoperfusion, contributed to its protections on brain mitochondria structure and function...
  34. ncbi Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis
    Gangjun Du
    Protein and Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Cancer Res 69:3205-12. 2009
    ..Naringenin could be an ideal therapeutic agent in the treatment of both cancer and fibrosis...
  35. pmc Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization
    Mohamed Al-Shabrawey
    Department of Oral Biology and Anatomy, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 60:614-24. 2011
    ..The goal of this study was to investigate whether 12-LOX plays a role in retinal neovascularization (NV)...
  36. ncbi Naringenin enhances the anti-tumor effect of doxorubicin through selectively inhibiting the activity of multidrug resistance-associated proteins but not P-glycoprotein
    Fa Yun Zhang
    Protein and Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
    Pharm Res 26:914-25. 2009
    ..The aim of this study is to interpret whether naringenin can reverse intrinsic and/or acquired resistance of cancer cells to chemotherapeutic agents...
  37. ncbi Naringenin reduces lung metastasis in a breast cancer resection model
    Lei Qin
    Protein and Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Protein Cell 2:507-16. 2011
    ..These results indicate that orally administered naringenin can inhibit the outgrowth of metastases after surgery via regulating host immunity. Thus, naringenin can be an ideal surgical adjuvant therapy for breast cancer patients...
  38. ncbi The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women
    Isabelle Demonty
    Unilever RampD Vlaardingen, Vlaardingen 3130 AC, The Netherlands
    J Nutr 140:1615-20. 2010
    ..In conclusion, pure hesperidin and naringin consumed in capsules at mealtime do not lower serum TC and LDL-C concentrations in moderately hypercholesterolemic men and women...
  39. ncbi Separation and determination of alpinetin and cardamonin by reverse micelle electrokinetic capillary chromatography
    Shumin Wang
    Department of Chemistry, Lanzhou University, Lanzhou 730000, China
    J Pharm Biomed Anal 43:1557-61. 2007
    ..19 and 0.14 microg mL(-1), respectively. The method was successfully applied for the quantification of alpinetin and cardamonin in Alpinia katsumadai Hayata and kuaiwei tablet with satisfactory recoveries in the range of 95.9-100.2%...
  40. ncbi Comparison of the characterization on binding of alpinetin and cardamonin to lysozyme by spectroscopic methods
    Wenying He
    Department of Chemistry, Lanzhou University, Lanzhou, China
    Int J Biol Macromol 39:165-73. 2006
    ..The efficiency of energy transfer provided the binding distances of 4.04 and 5.90 nm for alpinetin-LYSO and cardamonin-LYSO systems, respectively...
  41. ncbi Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats
    Fanrui Meng
    National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P R China
    Brain Res 1391:93-101. 2011
    ..In conclusion, these data demonstrate that pinocembrin alleviates blood-brain barrier injury induced by GCI/R in rats...
  42. ncbi The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production
    H Kim
    Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, Hoegi-Dong, Tongdaemun-ku, 130-701, Seoul, South Korea
    Neurosci Lett 309:67-71. 2001
    ....
  43. ncbi Baicalein attenuates oxidant stress in cardiomyocytes
    Zuo Hui Shao
    Section of Emergency Medicine, Department of Medicine, University of Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 282:H999-H1006. 2002
    ..We conclude that baicalein can scavenge ROS generation in cardiomyocytes and that it protects against cell death in an ischemia-reperfusion model when given only at reperfusion...
  44. ncbi In vitro analysis of iron chelating activity of flavonoids
    Premysl Mladenka
    Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
    J Inorg Biochem 105:693-701. 2011
    ..Isolated keto, hydroxyl, methoxyl groups or an ortho methoxy-hydroxy groups were not associated with iron chelation at all...
  45. ncbi High-performance liquid chromatography methods for the analysis of adrenergic amines and flavanones in Citrus aurantium L. var. amara
    Federica Pellati
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via G Campi 183 411 00 Modena, Italy
    Phytochem Anal 15:220-5. 2004
    ..10-0.35%) and in dry extracts (3.00-3.08%) and was present in the range 0.25-0.99% in herbal medicines. Flavanones were analysed in the same samples using a reverse-phase HPLC technique which allowed the identification and ..
  46. pmc Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression
    Jie Ding
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    J Biol Chem 287:641-9. 2012
    ..Thus, our study suggests the potential use of these flavones as an adjuvant for TRAIL-mediated anticancer therapy...
  47. pmc Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells
    Bin Wu
    Department of Dermatology, Xiangnan College, Chenzhou 423000, PR China
    BMC Cancer 11:527. 2011
    ..Ezrin serves as a promising target for anti-metastasis therapy. The aim of this study is to determine if the flavonoid bacailein inhibits the metastasis of skin cancer cells through Ezrin...
  48. ncbi Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects
    F I Kanaze
    Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur J Clin Nutr 61:472-7. 2007
    ..However, no information is available on the pharmacokinetics of the citrus flavanones hesperetin and naringenin after their oral administration to humans as pure aglycones...
  49. ncbi Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells
    Zi Ma
    Department of Bio Signal Analysis, Ames, Graduate School of Medicine, Yamaguchi University, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Blood 105:3312-8. 2005
    ....
  50. ncbi New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin
    Min Li-Weber
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Treat Rev 35:57-68. 2009
    ..This review is aimed to summarize the research results obtained since the last 20 years and to highlight the recently discovered molecular mechanisms...
  51. ncbi Biosynthesis and biotechnological production of flavanones: current state and perspectives
    Zachary L Fowler
    Department of Chemical and Biological Engineering, University at Buffalo, NY 14260, USA
    Appl Microbiol Biotechnol 83:799-808. 2009
    ..One of the major constituents within this chemical class are flavonoids, among which flavanones, as the precursor to all flavonoid structures, are the most prevalent...
  52. ncbi Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2
    Na Lu
    Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University, Nanjing 210009, People s Republic of China
    Life Sci 82:956-63. 2008
    ..Taken together, these findings strongly suggest that wogonin might be a promising antitumor drug...
  53. pmc Increased malonyl coenzyme A biosynthesis by tuning the Escherichia coli metabolic network and its application to flavanone production
    Zachary L Fowler
    Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, 303 Clifford C Furnas Hall, Buffalo, NY 14260, USA
    Appl Environ Microbiol 75:5831-9. 2009
    ..selected overexpressions, including those of genes required for the coexpression of the plant-derived flavanones, acetate assimilation, acetyl-CoA carboxylase, and the biosynthesis of coenzyme A...
  54. ncbi Neuroprotective effect of wogonin: potential roles of inflammatory cytokines
    Hua Zi Piao
    Department of Pharmacology, College of Medicine, Ewha Institute of Neuroscience, Ewha Womens University, Seoul, Korea
    Arch Pharm Res 27:930-6. 2004
    ..The data may indicate that wogonin has neuroprotective effect by preventing the overactivation of microglial cells, possibly by inactivating NF-kappaB signaling pathway...
  55. pmc Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury
    S F Chen
    Department of Physical Medicine and Rehabilitation, Cheng Hsin Rehabilitation Medical Center, Taipei, Taiwan, Republic of China
    Br J Pharmacol 155:1279-96. 2008
    ..The aim of this study was to investigate the effect of baicalein, a flavonoid possessing potent anti-inflammatory properties, on functional and histological outcomes and inflammatory cytokine expression, following TBI in rats...
  56. ncbi The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice
    Un Ju Jung
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702 701, Korea
    J Nutr 134:2499-503. 2004
    ....
  57. ncbi Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity
    Kyung Jin Woo
    Department of Immunology, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, Daegu 700 712, Republic of Korea
    Immunobiology 211:359-68. 2006
    ..Taken together, these results suggest that baicalein acts to inhibit inflammation through inhibition of COX-2 gene expression through blockade of C/EBPbeta DNA binding activity...
  58. ncbi 12/15-Lipoxygenase inhibitor baicalein suppresses PPAR gamma expression and nuclear translocation induced by cerebral ischemia/reperfusion
    Yan Wei Xu
    Tianjin Neurology Institute, Tianjin Medical University General Hospital, 154 Anshan Road Heping District, Tianjin 300052, China
    Brain Res 1307:149-57. 2010
    ..Together, these results suggest that I/R induces both PPAR gamma expression and translocation, probably through the activation by endogenous ligands in a 12/15-lipoxygenase inhibitor-sensitive way...
  59. ncbi Inhibitory effects of baicalein on the influenza virus in vivo is determined by baicalin in the serum
    Ge Xu
    School of Life Science and Technology, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu 210009, P R China
    Biol Pharm Bull 33:238-43. 2010
    ..2 microg/ml in the cytopathic effect assay. Our results showed that baicalein warrants further research as a potential antiinfluenza viral agent...
  60. pmc Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q
    Tin T Yow
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia
    Br J Pharmacol 163:1017-33. 2011
    ..Flavonoids have been shown to have significant health benefits and are a diverse source of compounds for identifying agents with novel mechanisms of action...
  61. ncbi DPP-IV inhibitory potential of naringin: an in silico, in vitro and in vivo study
    Hamendra Singh Parmar
    School of Biotechnology, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452001, MP, India
    Diabetes Res Clin Pract 97:105-11. 2012
    ..All the comparisons were made with the standard commercially available drug sitagliptin...
  62. ncbi Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells
    Z Gao
    Department of Chemistry, Huazhong University of Science and Technology, Wuhan, 430074, People s Republic of China
    Pharmacol Res 43:173-8. 2001
    ..These results demonstrated the protective effects of flavonoids originating from Scutellaria baicalensis Georgi on the oxidative injury of neuronal cells...
  63. pmc Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation
    Wei Tien Chang
    Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biochem 112:2873-81. 2011
    ..In conclusion, baicalein adjunct treatment confers anti-apoptotic protection against doxorubicin-induced cardiotoxicity without compromising its anti-cancer efficacy...
  64. ncbi Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells
    Hiroya Taniguchi
    Department of Molecular Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
    Cancer Res 68:8918-27. 2008
    ..These results indicate that, using two different pathways, baicalein exposes cancer surveillance of TRAIL and overcomes TRAIL resistance in cancer cells...
  65. ncbi Cytotoxic activities of several geranyl-substituted flavanones
    Karel Smejkal
    Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Palackeho 1 3, CZ 612 42, Czech Republic
    J Nat Prod 73:568-72. 2010
    Nine geranylated flavanones isolated from the fruits of Paulownia tomentosa (4-12) and two from the roots of Morus alba (13 and 14) were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts...
  66. ncbi Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways
    Yue Li
    Department of New Drug Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, and Institute of Infectious Diseases, Beijing Ditan Hospital, No 1, Xian Nong Tan Street, Beijing 100050, China
    Eur J Pharmacol 640:46-54. 2010
    ..Chlorogenic acid and ginsenoside Rf only induced constitutive androstane receptor-mediated CYP3A4 expression...
  67. ncbi Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats
    Leelavinothan Pari
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, India
    Eur J Pharmacol 650:364-70. 2011
    ..All these changes were supported by histopathological observations. These results clearly demonstrate that naringin has the potential in alleviating the toxic effects of nickel in rat liver...
  68. ncbi Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells
    So Jung Kim
    Department of Companion and Laboratory Animal Science, Kongju National University, Yesan 340 702, Republic of Korea
    Mol Med Rep 6:1443-9. 2012
    ....
  69. ncbi Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: biochemical and histopathological evidences
    M Rajadurai
    Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Toxicology 228:259-68. 2006
    ..The results of our study show that naringin possess anti-lipoperoxidative and antioxidant activity in experimentally induced cardiac toxicity...
  70. ncbi Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice
    Shih Jei Tsai
    School of Medicine, Chung Shan Medical University, Taichung City, Taiwan
    J Agric Food Chem 60:514-21. 2012
    ..05). These results indicate that naringenin could attenuate diabetic nephropathy via its anti-inflammatory and antifibrotic activities...
  71. pmc Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis
    Wei Dou
    Department of Medicine, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 7:e36075. 2012
    ..Pharmacological targeting of intestinal PXR using natural metabolically labile ligands could serve as effective and potent therapeutics for gut inflammation that avert systemic drug interactions...
  72. ncbi Antifungal activity of benzoic acid derivatives from Piper lanceaefolium
    Andres Lopez
    Department of Botany, University of British Columbia, 3529 6270 University Boulevard, Vancouver, B C, Canada V6T 1Z4
    J Nat Prod 65:62-4. 2002
    ..Lanceaefolic acid methyl ester (3) and pinocembrin chalcone displayed activity against Candida albicans with a minimal inhibitory concentration value of 100 microg/mL in both cases...
  73. ncbi Anti-inflammatory flavonoids from Cryptocarya chingii
    Rui Feng
    Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
    Phytochemistry 76:98-105. 2012
    ..Anti-inflammatory effects of the compounds were evaluated using in vitro assays. At 20 μM concentration, three compounds significantly inhibited TNFα-induced NF-кB activation and LPS-induced IL-1β expression...
  74. ncbi Baicalein inhibits pulmonary carcinogenesis-associated inflammation and interferes with COX-2, MMP-2 and MMP-9 expressions in-vivo
    Naveenkumar Chandrashekar
    Department of Biochemistry, University of Madras, Maraimalai Campus, Guindy, Chennai, India
    Toxicol Appl Pharmacol 261:10-21. 2012
    ..The chemotherapeutic effect observed in the present study is attributed to the potent anti-inflammatory and antioxidant potential by BE against pulmonary carcinogenesis...
  75. ncbi Antifungal flavanones and prenylated hydroquinones from Piper crassinervium Kunth
    Ana Paula Danelutte
    Instituto de Quimica, Universidade de Sao Paulo, C P 26077, CEP 05599 970, Sao Paulo, SP, Brazil
    Phytochemistry 64:555-9. 2003
    ..EtOAc extract from leaves of Piper crassinervium yielded three prenylated hydroquinones together with two known flavanones naringenin and sakuranetin...
  76. ncbi Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation
    Mandipika Jain
    School of Biotechnology, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore, 452001, MP, India
    Inflamm Res 60:483-91. 2011
    ..Anti-inflammatory and antioxidative potential of hesperidin and naringin was carried out considering the rat air pouch model of inflammation...
  77. pmc Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction
    Ji Hyun Choi
    Department of Biochemistry and Molecular Biology, School of Medicine, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul 130 701, Korea
    Exp Mol Med 42:811-22. 2010
    ..Taken together, these results suggest that baicalein could protect HT22 neuronal cells against ER stress-induced apoptosis by reducing CHOP induction as well as ROS accumulation and mitochondrial damage...
  78. ncbi Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax
    Meng Zhang
    Department of Pathology, The First Affiliated Hospital, Sun Yat Sen University, 58, Zhongshan Road II, Guangzhou 510080, China
    Life Sci 92:55-62. 2013
    ..We aim to investigate the anticancer effects and associated mechanisms of wogonin on human multiple myeloma cell line in vitro...
  79. ncbi Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells
    Yoonkyung Woo
    Division of Bioscience and Biotechnology, BMIC, Konkuk University, MoleNBio, Seoul 143 701, Republic of Korea
    Int J Mol Med 29:403-8. 2012
    ..In addition, in order to design flavanone derivatives that show better anticancer activity, structure-activity relationships were examined...
  80. ncbi Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell
    Mika Himeji
    Department of Biotechnology, Faculty of Engineering, University of Yamanashi, 4 3 11 Takeda, Kofu, Yamanashi 400 8511, Japan
    Cancer Lett 245:269-74. 2007
    ..Physiological analyses in THP-1 cells showed that wogonin induced cell cycle arrest at G(2)/M phase and apoptosis. This is the first report discovering a cancer-specific apoptosis-inducing activity of wogonin...
  81. ncbi Wogonin inhibits inducible prostaglandin E(2) production in macrophages
    I Wakabayashi
    Department of Hygiene and Preventive Medicine, School of Medicine, Yamagata University, Iida nishi 2 2 2, 990 9585, Yamagata, Japan
    Eur J Pharmacol 406:477-81. 2000
    ..The former action requires much lower doses of wogonin. These wogonin actions may explain, in part, its anti-inflammatory action...
  82. ncbi Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis
    Zong Fang Li
    Department of Surgery, Second Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an 710004, China
    Hepatobiliary Pancreat Dis Int 8:201-8. 2009
    ....
  83. ncbi Antifeedant activity of ethanolic extract from Flourensia oolepis and isolation of pinocembrin as its active principle compound
    Georgina N Diaz Napal
    Laboratory of Fine Chemicals and Natural Products, Faculty of Chemical Sciences, Catholic University of Cordoba, Camino a Alta Gracia Km 10, 5000 Cordoba, Argentina
    Bioresour Technol 100:3669-73. 2009
    ..The effect of these on the feeding behavior of E. paenulata was also studied...
  84. pmc Iron-binding and anti-Fenton properties of baicalein and baicalin
    Carlos A Perez
    Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, MA 02747 2300, USA
    J Inorg Biochem 103:326-32. 2009
    ..Modulation of metal homeostasis and the inhibition of Fenton chemistry may be one of the possible mechanisms for herbal medicine...
  85. ncbi Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide
    Yan Hua Lu
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, PR China
    Neurosci Lett 484:6-11. 2010
    ..In this study, we investigated the protective actions of citrus flavanones naringin and nobiletin against the cytotoxicity induced by exposure to hydrogen peroxide (H(2)O(2)) (150μM, 3h) ..
  86. ncbi Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in D-GalN/LPS induced acute liver failure in murine models
    Yan Ling Wu
    College of Pharmacy, Yanbian University, Yanji, 133002, Jilin Province, China
    Chem Biol Interact 188:526-34. 2010
    ..The results support the investigation of baicalein as a therapeutic candidate for acute liver apoptosis or injury and indicate that baicalein might inhibit liver apoptosis by mediating one or more of these pathways...
  87. ncbi Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin
    Ping Dong
    Department of General Surgery, Xinhua Hospital, Affiliated to School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai 200092, China
    J Ethnopharmacol 137:1373-80. 2011
    ..However, the detailed mechanism of anti-metastasis effect of wogonin, a main active ingredient of Scutellaria baicalensis, remains elusive...
  88. pmc Identification of a natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression
    Jinbo Gao
    Department of Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    Mol Cancer Ther 10:1774-83. 2011
    ..These findings indicate that identifying enhancers of IRF-1 activity may have utility in anticancer therapies and that cell-based screening for activation of transcription factors can be a useful approach for drug discovery...
  89. ncbi Pinocembrin protects the neurovascular unit by reducing inflammation and extracellular proteolysis in MCAO rats
    Mei Gao
    Peking Union Medical College, Institute of Materia Medica and Chinese Academy of Medical Sciences, Beijing, China
    J Asian Nat Prod Res 12:407-18. 2010
    ..This resulted in the protective action of 1 on the NVU...
  90. ncbi Flavonoid baicalein attenuates activation-induced cell death of brain microglia
    Kyoungho Suk
    Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University, 92 Chilam dong, Jinju, Kyungnam 660 751, Korea
    J Pharmacol Exp Ther 305:638-45. 2003
    ..Also, the AICD-inhibiting effects of baicalein were specific for the inflammatory stimulus that activated microglia...
  91. ncbi Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort
    Raul Zamora-Ros
    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology ICO IDIBELL, L Hospitalet de Llobregat, Spain
    Br J Nutr 106:1915-25. 2011
    Flavonols, flavanones and flavones (FLAV) are sub-classes of flavonoids that exert cardioprotective and anti-carcinogenic properties in vitro and in vivo...
  92. ncbi Baicalein is neuroprotective in rat MCAO model: role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2
    Lili Cui
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China
    Pharmacol Biochem Behav 96:469-75. 2010
    ..The results indicated that baicalein protected the brain from damage caused by MCAO, and this effect may be through downregulation of 12/15-LOX, p38 MAPK and cPLA2 expression...
  93. ncbi Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats
    Yen Mei Lee
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    J Cardiovasc Pharmacol 58:133-42. 2011
    ..The suppression of nuclear factor-κB and p38 mitogen-activated protein kinase activation and the inhibition of monocyte chemoattractant protein-1 expression contribute to the beneficial effects of wogonin...
  94. ncbi Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats
    Yu Chi Hou
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
    Planta Med 77:455-60. 2011
    ..In conclusion, the glucuronides/sulfates of baicalein and wogonin were exclusively present in the circulation, whereas their free forms appeared in the lung, liver, and kidney...
  95. pmc Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells
    Hiroki Takahashi
    Department of Surgery, UCLA Center for Excellence in Pancreatic Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Biochim Biophys Acta 1813:1465-74. 2011
    ..Our results provide evidence that baicalein induces apoptosis in pancreatic cancer cells through down-regulation of the anti-apoptotic Mcl-1 protein...
  96. ncbi Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases
    Joshua D Deschamps
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Bioorg Med Chem 14:4295-301. 2006
    ..A structurally related flavonoid, apigenin, is not reductive, however, molecular modeling suggests a hydrogen bond with Thr591 may account for its inhibitor potency...
  97. ncbi Phenolic compounds as selective antineoplasic agents against multidrug-resistant human cancer cells
    Noelia Duarte
    Institute for Medicines and Pharmaceutical Sciences iMed UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
    Planta Med 76:975-80. 2010
    ..The results of this study suggest that some phenolic compounds might be valuable for the treatment of multidrug-resistant cancer cells...
  98. ncbi Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids
    S C Shen
    Department of Dermatology, School of Medicine, Taipei Medical University, and Department of Dermatology, Taipei Municipal Wan Fang Hospital Affiliated to Taipei Medical University, 111 Xinglong Road, Taipei, Taiwan
    Neuroscience 140:477-89. 2006
    ..Kaempferol and wogonin exhibit effective inhibitory effects on lipopolysaccharide/12-o-tetradecanoylphorbol 13-acetate-induced events, and thus possess the potential for further development...
  99. ncbi Inhibitory effect of baicalein, a flavonoid in Scutellaria Root, on eotaxin production by human dermal fibroblasts
    T Nakajima
    Department of Bioregulatory Function, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Planta Med 67:132-5. 2001
    ..These results help explain the pharmacological efficacy of Scutellaria Root in the treatment of bronchial asthma since it would suppress eotaxin associated recruitment of eosinophils...
  100. ncbi Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi
    V Lakshmi
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India
    Acta Trop 116:127-33. 2010
    ..Thus naringenin and flavone may provide a lead for design and development of new antifilarial agent(s). This is the first report on antifilarial efficacy of flavonoids...
  101. ncbi Abatement by naringin of lomefloxacin-induced genomic instability in mice
    Sabry M Attia
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Mutagenesis 23:515-21. 2008
    ..Thus, naringin might be a good alternative to reduce genotoxic risks associated with lomefloxacin therapy...

Research Grants29

  1. Cardioprotective Effects of Dietary Flavonoids in the Framingham Offspring Cohort
    Paul Jacques; Fiscal Year: 2009
    ..evidence of cardiovascular disease risk reduction is available for the flavanol class (including catechins and flavanones)...
  2. Synthesis and Evaluation of Anti-Tumor Flavanoids
    ANTOINETTE EVADNEY NIBBS; Fiscal Year: 2011
    ..Specific Aim 2: Synthesize the flavanone natural products kurarinone and isosilybin B. Both flavanones display anti-PCa activity, yet no enantioselective syntheses of these molecules has been reported...
  3. Synthesis of Anticancer Pyran Natural Products
    Karl A Scheidt; Fiscal Year: 2010
    ..are designed to feature catalytic stereoselective pyran-forming reactions, the enantioselective synthesis of flavanones, and incorporate multiple bond forming sequences...
  4. CHALCONE ISOMERASE--MECHANISM OF CATALYSIS
    RODNEY BEDNAR; Fiscal Year: 1990
    ..The isomerization of chalcones to flavanones is an intramolecular reaction and a membrane of the class of biochemical reactions involving addition to a ..
  5. ENDOCRINE DISRUPTING CHEMICALS AND AROMATASE
    Shiuan Chen; Fiscal Year: 2009
    ..The proposed studies will focus on 1014 phytochemicals (including chalcones, chromones, coumarins, flavanones, flavones and isoflavones) that would be purchased from Indofine Co (Somerville, New Jersey)...
  6. Case-Control Study of Adenoma in Sao Paulo Japanese
    Loic Le Marchand; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Ethnic/Racial Minorities in the Colon CFR
    Loic Le Marchand; Fiscal Year: 2008
    ..abstract_text> ..
  8. Green Tea Targets COX-2/PGE2 and EFGR Pathways in NSCLC via Stimulating Annexin 1
    Qing Yi Lu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. MOLECULAR REGULATION OF THE HUMAN BRCA 1 GENE
    DONATO ROMAGNOLO; Fiscal Year: 2003
    ..Specific aim #3 will examine the function of BRCA-1 in cell cycle regulation at different levels of genotoxic damage induced by PAHs. ..
  10. PLANT ANTITUMOR AGENTS
    Kuo Hsiung Lee; Fiscal Year: 2009
    ....
  11. Endothelial Function in the Cerebral Circulation
    Frank Faraci; Fiscal Year: 2009
    ..These studies should provide new insight into mechanisms of cerebral vascular protection during hypertension. ..
  12. Hawaii Colorectal Cancer Family Registry
    Loic Le Marchand; Fiscal Year: 2008
    ..We will also propose a CFR pilot study exploring the feasibility of assessing assorted mating as evidence for population stratification. ..
  13. Prevention of skin cancer by green tea polyphenols
    Santosh Katiyar; Fiscal Year: 2009
    ..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
  14. Prevention of Photocarcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2003
    ..abstract_text> ..
  15. Diet, Genetic Susceptibility and Colorectal Neoplasia
    Loic Le Marchand; Fiscal Year: 2006
    ..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..
  16. Proanthocyanidins: Novel Skin Cancer Preventive Agent
    Santosh Katiyar; Fiscal Year: 2006
    ..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
  17. Effects of Natural Agents with Fluoride on Caries
    Hyun Koo; Fiscal Year: 2004
    ....
  18. Prevention of UV-carcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2004
    ..abstract_text> ..
  19. FLAVONOID BIOAVAILABILITY IN HUMANS-CELLULAR STUDIES
    Thomas Walle; Fiscal Year: 2005
    ..The findings from the proposed studies should help us understand the bioavailability of the flavonoids, facilitating optimization of the chemopreventive utility of these natural or synthetic compounds. ..
  20. Chemoprevention of prostate cancer by resveratrol
    Tze Chen Hsieh; Fiscal Year: 2005
    ....
  21. GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERS
    Loic Le Marchand; Fiscal Year: 2004
    ..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
  22. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
    ....
  23. Liquid Chromatography Mass Spectrometry system
    Adrian Franke; Fiscal Year: 2005
    ..abstract_text> ..
  24. The TGFbeta Pathway, Gene Variants and Colorectal Neopl*
    Loic Le Marchand; Fiscal Year: 2005
    ..abstract_text> ..
  25. CHEMICAL DIVERSITY LIBRARIES FROM MEDICINAL PLANTS (RMI)
    Kuo Hsiung Lee; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  26. An Exploratory Center for Obesity Research (RMI)
    Adam Drewnowski; Fiscal Year: 2006
    ..By promoting interagency collaborations, these efforts will help the NIH develop a roadmap on how to effectively translate research findings into national, state, and local health policy. [unreadable] [unreadable]..
  27. ALTERATIONS IN THE DYAD CLEFT IN FAILING CARDIOMYOCYTES
    ROBERT HAWORTH; Fiscal Year: 2002
    ..End of Abstract) ..
  28. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  29. CALCIUM AND THE PATHOPHYSIOLOGY OF THE ADULT HEART CELL
    ROBERT HAWORTH; Fiscal Year: 2001
    ....