flavonoids

Summary

Summary: A group of phenyl benzopyrans named for having structures like FLAVONES.

Top Publications

  1. ncbi Flavonoids as antioxidants
    P G Pietta
    Institute of Advanced Biomedical Technologies, National Council of Research Via F lli Cervi 93, 20090 Segrate Mi, Italy
    J Nat Prod 63:1035-42. 2000
  2. ncbi A new approach to study medicinal plants with tannins and flavonoids contents from the local knowledge
    Thiago Antônio de Sousa Araújo
    Laboratório de Etnobotânica Aplicada, Departamento de Biologia, Área de Botânica, Universidade Federal Rural de Pernambuco, Av Dom Manoel de Medeiros s n, Dois Irmaos, CEP 52171 900 Recife, Pernambuco, Brazil
    J Ethnopharmacol 120:72-80. 2008
  3. ncbi Biosynthesis of flavonoids and effects of stress
    Brenda Winkel-Shirley
    Department of Biology, Virginia Tech, Blacksburg, Virginia 24061 0406, USA
    Curr Opin Plant Biol 5:218-23. 2002
  4. ncbi Flavonoids: antioxidants or signalling molecules?
    Robert J Williams
    Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 9RT, UK
    Free Radic Biol Med 36:838-49. 2004
  5. ncbi Polyphenols: food sources and bioavailability
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Am J Clin Nutr 79:727-47. 2004
  6. ncbi Flavonoids: a review of probable mechanisms of action and potential applications
    R J Nijveldt
    Department of Surgery, Vrije Universiteit Medical Center, Amsterdam, Netherlands
    Am J Clin Nutr 74:418-25. 2001
  7. ncbi Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Am J Clin Nutr 81:230S-242S. 2005
  8. ncbi Recent advances in the transcriptional regulation of the flavonoid biosynthetic pathway
    Imène Hichri
    UMR 1287 Ecophysiologie et Génomique Fonctionnelle de Vigne, Universite de Bordeaux, INRA, Institut des Sciences de Vigne et du Vin, 210 Chemin de Leysotte, 33882 Villenave d Ornon, France
    J Exp Bot 62:2465-83. 2011
  9. ncbi Antimicrobial activity of flavonoids
    T P Tim Cushnie
    Int J Antimicrob Agents 26:343-56. 2005
  10. ncbi Polyphenols and disease risk in epidemiologic studies
    Ilja C W Arts
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Am J Clin Nutr 81:317S-325S. 2005

Detail Information

Publications343 found, 100 shown here

  1. ncbi Flavonoids as antioxidants
    P G Pietta
    Institute of Advanced Biomedical Technologies, National Council of Research Via F lli Cervi 93, 20090 Segrate Mi, Italy
    J Nat Prod 63:1035-42. 2000
    b>Flavonoids are phenolic substances isolated from a wide range of vascular plants, with over 8000 individual compounds known...
  2. ncbi A new approach to study medicinal plants with tannins and flavonoids contents from the local knowledge
    Thiago Antônio de Sousa Araújo
    Laboratório de Etnobotânica Aplicada, Departamento de Biologia, Área de Botânica, Universidade Federal Rural de Pernambuco, Av Dom Manoel de Medeiros s n, Dois Irmaos, CEP 52171 900 Recife, Pernambuco, Brazil
    J Ethnopharmacol 120:72-80. 2008
    ..strategies for identifying plants that could be interesting in terms of their phenolic compounds (especially flavonoids and tannins) by comparing a new index in which priority-determining criteria are based on the free-listing ..
  3. ncbi Biosynthesis of flavonoids and effects of stress
    Brenda Winkel-Shirley
    Department of Biology, Virginia Tech, Blacksburg, Virginia 24061 0406, USA
    Curr Opin Plant Biol 5:218-23. 2002
    The accumulation of red or purple flavonoids is a hallmark of plant stress. Mounting evidence points to diverse physiological functions for these compounds in the stress response...
  4. ncbi Flavonoids: antioxidants or signalling molecules?
    Robert J Williams
    Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 9RT, UK
    Free Radic Biol Med 36:838-49. 2004
    ..are accumulating that report the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. While there has been a major focus on the antioxidant properties, there is an emerging view that flavonoids, ..
  5. ncbi Polyphenols: food sources and bioavailability
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Am J Clin Nutr 79:727-47. 2004
    ..A thorough knowledge of the bioavailability of the hundreds of dietary polyphenols will help us to identify those that are most likely to exert protective health effects...
  6. ncbi Flavonoids: a review of probable mechanisms of action and potential applications
    R J Nijveldt
    Department of Surgery, Vrije Universiteit Medical Center, Amsterdam, Netherlands
    Am J Clin Nutr 74:418-25. 2001
    The aim of this review, a summary of the putative biological actions of flavonoids, was to obtain a further understanding of the reported beneficial health effects of these substances...
  7. ncbi Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Am J Clin Nutr 81:230S-242S. 2005
    ..Data are still too limited for assessment of hydroxycinnamic acids and other polyphenols. These data may be useful for the design and interpretation of intervention studies investigating the health effects of polyphenols...
  8. ncbi Recent advances in the transcriptional regulation of the flavonoid biosynthetic pathway
    Imène Hichri
    UMR 1287 Ecophysiologie et Génomique Fonctionnelle de Vigne, Universite de Bordeaux, INRA, Institut des Sciences de Vigne et du Vin, 210 Chemin de Leysotte, 33882 Villenave d Ornon, France
    J Exp Bot 62:2465-83. 2011
    b>Flavonoids are secondary metabolites involved in several aspects of plant development and defence...
  9. ncbi Antimicrobial activity of flavonoids
    T P Tim Cushnie
    Int J Antimicrob Agents 26:343-56. 2005
    b>Flavonoids are ubiquitous in photosynthesising cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, wine, propolis and honey...
  10. ncbi Polyphenols and disease risk in epidemiologic studies
    Ilja C W Arts
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Am J Clin Nutr 81:317S-325S. 2005
    ..Data obtained to date suggest beneficial effects of both flavonoids and lignans on cardiovascular diseases but not on cancer, with the possible exception of lung cancer...
  11. ncbi Flavonoids: a colorful model for the regulation and evolution of biochemical pathways
    Ronald Koes
    Department of Genetics, Institute for Molecular Biological Sciences, Vrije Universiteit, De Boelelaan 1085, 1081HV Amsterdam, The Netherlands
    Trends Plant Sci 10:236-42. 2005
    ..Moreover, because pigmentation is studied in a variety of species, it provides unique molecular insights into the evolution of biochemical pathways and regulatory networks...
  12. ncbi Dietary polyphenols and the prevention of diseases
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Centre de Recherche de Clermont Ferrand Theix, St Genes Champanelle, France
    Crit Rev Food Sci Nutr 45:287-306. 2005
    ..the risk of myocardial infarction and the consumption of tea and wine or the intake level of some particular flavonoids, but no clear associations have been found between cancer risk and polyphenol consumption...
  13. ncbi Flavonoids as antioxidants in plants: location and functional significance
    Giovanni Agati
    Consiglio Nazionale delle Ricerche, Istituto di Fisica Applicata Carrara, Via Madonna del Piano 10, I 50019 Sesto F no, Firenze, Italy
    Plant Sci 196:67-76. 2012
    Stress-responsive dihydroxy B-ring-substituted flavonoids have great potential to inhibit the generation of reactive oxygen species (ROS) and reduce the levels of ROS once they are formed, i.e., to perform antioxidant functions...
  14. ncbi Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials
    Lee Hooper
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 88:38-50. 2008
    ..The beneficial effects of flavonoid consumption on cardiovascular risk are supported by mechanistic and epidemiologic evidence...
  15. ncbi Absorption and metabolism of polyphenols in the gut and impact on health
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Biomed Pharmacother 56:276-82. 2002
    ..Alternatively, some health effects of polyphenols may not require their absorption through the gut barrier. Their role as iron chelators in the gut lumen is briefly discussed...
  16. ncbi The biochemistry and medical significance of the flavonoids
    Bent H Havsteen
    Department of Biochemistry, University of Kiel, Olshausenstrasse 40, D 24098, Kiel, Germany
    Pharmacol Ther 96:67-202. 2002
    b>Flavonoids are plant pigments that are synthesised from phenylalanine, generally display marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are excited by UV light, and are ubiquitous to green plant ..
  17. ncbi The role of flavonoids in root-rhizosphere signalling: opportunities and challenges for improving plant-microbe interactions
    Samira Hassan
    Division of Plant Science, Research School of Biology, Australian National University, Linnaeus Way, Canberra, ACT 0200, Australia
    J Exp Bot 63:3429-44. 2012
    ..This review highlights some of the known function of flavonoids in the rhizosphere, in particular for the interaction of roots with microorganisms...
  18. ncbi Flavonoids and cancer prevention: a review of the evidence
    Donato F Romagnolo
    Department of Nutritional Sciences and University of Arizona Cancer Center, University of Arizona, Tucson, Arizona 85721 0038, USA
    J Nutr Gerontol Geriatr 31:206-38. 2012
    ..to review data from epidemiological and preclinical studies addressing the potential benefits of diets based on flavonoids for cancer prevention...
  19. ncbi Genetics and biochemistry of seed flavonoids
    Loic Lepiniec
    Seed Biology, Institut Jean Pierre Bourgin IJPB, INRA, 78026 Versailles, France
    Annu Rev Plant Biol 57:405-30. 2006
    b>Flavonoids are secondary metabolites that accumulate in most plant seeds and are involved in physiological functions such as dormancy or viability...
  20. ncbi Dietary phenolics: chemistry, bioavailability and effects on health
    Alan Crozier
    Graham Kerr Building, Division of Ecology and Evolutionary Biology, University of Glasgow, Glasgow G12 8QQ, UK
    Nat Prod Rep 26:1001-43. 2009
    ..This review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the C6-C3-C6 flavonoids-anthocyanins, dihydrochalcones, flavan-3-ols, flavanones, flavones, flavonols and isoflavones...
  21. ncbi Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents
    Edy Meiyanto
    Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
    Asian Pac J Cancer Prev 13:427-36. 2012
    ..Natural products being rich of flavonoids are those fruits belong to the genus citrus...
  22. ncbi Recent advances in understanding the antibacterial properties of flavonoids
    T P Tim Cushnie
    Faculty of Medicine, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham 44150, Thailand
    Int J Antimicrob Agents 38:99-107. 2011
    Antibiotic resistance is a major global problem and there is a pressing need to develop new therapeutic agents. Flavonoids are a family of plant-derived compounds with potentially exploitable activities, including direct antibacterial ..
  23. ncbi Dietary flavonoids: bioavailability, metabolic effects, and safety
    Julie A Ross
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Annu Rev Nutr 22:19-34. 2002
    b>Flavonoids comprise the most common group of plant polyphenols and provide much of the flavor and color to fruits and vegetables. More than 5000 different flavonoids have been described...
  24. ncbi Health effects of quercetin: from antioxidant to nutraceutical
    Agnes W Boots
    Department of Pharmacology and Toxicology, Faculty of Medicine Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Pharmacol 585:325-37. 2008
    Quercetin, a member of the flavonoids family, is one of the most prominent dietary antioxidants...
  25. ncbi Flavonoid intake and risk of chronic diseases
    Paul Knekt
    National Public Health Institute, Helsinki, Finland
    Am J Clin Nutr 76:560-8. 2002
    b>Flavonoids are effective antioxidants and may protect against several chronic diseases.
  26. ncbi Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Raul Zamora-Ros
    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology ICO IDIBELL, Avda Gran Via 199 203, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Br J Nutr 109:1498-507. 2013
    ..This dietary pattern is based on higher consumption of plant products that are rich in flavonoids. We compared the total flavonoid dietary intakes, their food sources and various lifestyle factors between MED ..
  27. ncbi Flavonoids: new roles for old molecules
    Charles S Buer
    Genomic Interactions Group, ARC Centre of Excellence for Integrative Legume Research, Research School of Biology, College of Medicine, Biology, and Environment, The Australian National University, Canberra ACT 2601, Australia
    J Integr Plant Biol 52:98-111. 2010
    b>Flavonoids are ubiquitous in the plant kingdom and have many diverse functions including defense, UV protection, auxin transport inhibition, allelopathy, and flower coloring...
  28. ncbi Activity of plant flavonoids against antibiotic-resistant bacteria
    H X Xu
    Department of Applied Oral Science, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Phytother Res 15:39-43. 2001
    Thirty eight plant-derived flavonoids representing seven different structural groups were tested for activities against antibiotic-resistant bacteria using the disc-diffusion assay and broth dilution assay...
  29. ncbi Anti-inflammatory plant flavonoids and cellular action mechanisms
    Hyun Pyo Kim
    College of Pharmacy, Kangwon National University, Chunchon, Korea
    J Pharmacol Sci 96:229-45. 2004
    Plant flavonoids show anti-inflammatory activity in vitro and in vivo. Although not fully understood, several action mechanisms are proposed to explain in vivo anti-inflammatory action...
  30. pmc Characterization of a grapevine R2R3-MYB transcription factor that regulates the phenylpropanoid pathway
    Laurent Deluc
    Unité Mixte de Recherche 619, Physiologie et Biotechnologie Végétales, Universite Bordeaux 1, Universite Bordeaux 2, Institut National de la Recherche Agonomique, Centre de Recherche de Bordeaux, 33883 Villenave d Ornon, France
    Plant Physiol 140:499-511. 2006
    ..These findings suggest that VvMYB5a may be involved in the control of different branches of the phenylpropanoid pathway in grapevine...
  31. ncbi Effects of flavonoids and other polyphenols on inflammation
    R Gonzalez
    Department of Pharmacology, CIBERehd, School of Pharmacy, University of Granada, Granada, Spain
    Crit Rev Food Sci Nutr 51:331-62. 2011
    b>Flavonoids are a family of polyphenolic compounds which are widespread in nature (vegetables) and are consumed as part of the human diet in significant amounts...
  32. ncbi Significance of flavonoids in plant resistance and enhancement of their biosynthesis
    D Treutter
    Unit of Fruit Science, Center of Life Sciences Weihenstephan, Technical University of Munich, Alte Akademie 16, 85350 Freising, Germany
    Plant Biol (Stuttg) 7:581-91. 2005
    The roles of flavonoids in plant defence against pathogens, herbivores, and environmental stress are reviewed and their significant contribution to plant resistance is discussed...
  33. ncbi Flavonoids: promising anticancer agents
    Wenying Ren
    Department of Hematology, 2nd Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P R China
    Med Res Rev 23:519-34. 2003
    b>Flavonoids are polyphenolic compounds that are ubiquitously in plants. They have been shown to possess a variety of biological activities at nontoxic concentrations in organisms...
  34. ncbi Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    Gary Williamson
    Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
    Am J Clin Nutr 81:243S-255S. 2005
    ..The length of human intervention studies should be increased, to more closely reflect the long-term dietary consumption of polyphenols...
  35. ncbi Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
    Sonia Ramos
    Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain
    J Nutr Biochem 18:427-42. 2007
    Epidemiological studies have described the beneficial effects of dietary polyphenols (flavonoids) on the reduction of the risk of chronic diseases, including cancer...
  36. pmc Dietary flavonoids and flavonoid-rich foods are not associated with risk of type 2 diabetes in postmenopausal women
    Jennifer A Nettleton
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    J Nutr 136:3039-45. 2006
    b>Flavonoids have anti-inflammatory and antioxidative effects and thus may protect against diabetes...
  37. ncbi Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB
    Fera Y Goh
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore
    Eur J Pharmacol 679:109-16. 2012
    ..Our findings implicate a potential therapeutic value of fisetin in the treatment of asthma through negative regulation of NF-κB pathway...
  38. ncbi Flavonoids as anti-inflammatory agents
    Mauro Serafini
    Antioxidant Research Laboratory, INRAN, Via Ardeatina 546, 00178 Rome, Italy
    Proc Nutr Soc 69:273-8. 2010
    ..focus its attention on a class of secondary metabolites extensively present in a wide range of plant foods: the flavonoids, suggested as having different biological roles...
  39. ncbi Flavonoids and metabolic syndrome
    Monica Galleano
    Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Ann N Y Acad Sci 1259:87-94. 2012
    ..indicates that several mechanisms, associated or not with antioxidant actions, are involved in the effects of flavonoids on health...
  40. ncbi Antioxidant activity of food constituents: an overview
    Ilhami Gulcin
    Department of Chemistry, Ataturk University, 25240 Erzurum, Turkey
    Arch Toxicol 86:345-91. 2012
    ..In addition, there are given some chemical and kinetic basis and technical details of the used methods...
  41. ncbi Flavonoids with gastroprotective activity
    Kelly Samara de Lira Mota
    Laboratório de Tecnologia Farmacêutica Prof Delby Fernandes de Medeiros, LTF, Universidade Federal da Paraiba, UFPB, Joao Pessoa, PB, Brazil
    Molecules 14:979-1012. 2009
    ..This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health ..
  42. ncbi The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco
    A Aharoni
    Business Unit Cell Cybernetics, Plant Research International, PO Box 16, 6700 AA Wageningen, The Netherlands
    Plant J 28:319-32. 2001
    ....
  43. ncbi Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity
    Veronica Dewanto
    Department of Food Science and Institute of Comparative and Environmental Toxicology, Stocking Hall, Cornell University, Ithaca, New York 14853, USA
    J Agric Food Chem 50:3010-4. 2002
    ..bioaccessible lycopene content in tomatoes and produced no significant changes in the total phenolics and total flavonoids content, although loss of vitamin C was observed. The raw tomato had 0.76 +/- 0...
  44. ncbi Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes
    Yuh Chiang Shen
    National Research Institute of Chinese Medicine, Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Eur J Pharmacol 465:171-81. 2003
    ....
  45. ncbi The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids
    Bashir M Rezk
    Department of Pharmacology and Toxicology, Faculty of Medicine, Universiteit Maastricht P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochem Biophys Res Commun 295:9-13. 2002
    ..The antioxidant pharmacophore in the dihydrochalcone phloretin, i.e., the 2,6-dihydroxyacetophenone group, is different from the antioxidant pharmacophores previously reported in flavonoids.
  46. ncbi Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense
    Hyuncheol Oh
    Laboratory of Cell Signaling Regulation, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 333, South Korea
    J Ethnopharmacol 95:421-4. 2004
    ..resulted in the isolation of two phenolic petrosins, onitin (1) and onitin-9-O-glucoside (2), along with four flavonoids, apigenin (3), luteolin (4), kaempferol-3-O-glucoside (5), and quercetin-3-O-glucoside (6)...
  47. ncbi Beneficial effects of green tea--a review
    Carmen Cabrera
    Departamento de Nutricion y Bromatologia, Facultad de Farmacia, Campus Universitario de Granada, Granada, Spain
    J Am Coll Nutr 25:79-99. 2006
    ....
  48. ncbi Structure-activity relationships of flavonoids in the cellular antioxidant activity assay
    Kelly L Wolfe
    Department of Food Science, Cornell University, Ithaca, New York 14853 7201, USA
    J Agric Food Chem 56:8404-11. 2008
    ..Structure-activity relationships of flavonoids have been determined in many chemistry antioxidant activity assays, and they vary with the protocols...
  49. ncbi Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption
    G Zhang
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, N T Hong Kong SAR, PR China
    Bone 38:818-25. 2006
    Factorial design was used to test our hypothesis whether a group of flavonoids (FE) derived from herbal Epimedium Brevicornum Maxim exerted its preventive effects on estrogen-deficiency-induced osteoporosis mainly through an enhancement ..
  50. pmc Flavonoids act as negative regulators of auxin transport in vivo in arabidopsis
    D E Brown
    Department of Biology, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Plant Physiol 126:524-35. 2001
    ..These synthetic auxin transport inhibitors may act by mimicking endogenous molecules. Flavonoids, a class of secondary plant metabolic compounds, have been suggested to be auxin transport inhibitors based on ..
  51. ncbi Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae)
    V Kuete
    Department of Biochemistry, Faculty of Science, University of Dschang, P O BOX 67, Dschang, Cameroon
    J Ethnopharmacol 120:17-24. 2008
    ..Ficus chlamydocarpa (FCR), Ficus cordata (FCB), mixture of the two plants (FCM), as well as that of the isolated flavonoids Alpinumisoflavone (2), Genistein (3), Laburnetin (4), Luteolin (5) (isolated from FCR), Catechin (7) and ..
  52. ncbi Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women
    Pamela J Mink
    Exponent, Inc, Washington, DC 20036, USA
    Am J Clin Nutr 85:895-909. 2007
    Dietary flavonoids may have beneficial cardiovascular effects in human populations, but epidemiologic study results have not been conclusive.
  53. ncbi Polyphenols: antioxidants and beyond
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, Institut National de la Recherche Agronomique, Saint Genes Champanelle, France
    Am J Clin Nutr 81:215S-217S. 2005
    ....
  54. ncbi New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin
    Min Li-Weber
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Treat Rev 35:57-68. 2009
    ..This review is aimed to summarize the research results obtained since the last 20 years and to highlight the recently discovered molecular mechanisms...
  55. ncbi Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines
    S Chen
    Brander Cancer Research Institute, New York Medical College, Hawthorne, NY 10532, USA
    Cell Prolif 34:293-304. 2001
    ..8 +/- 0.7 and 17.7 +/- 3.4, respectively. Thus, it appears that cell growth inhibition by these flavonoids is independent of androgen receptor status...
  56. pmc The Arabidopsis TT2 gene encodes an R2R3 MYB domain protein that acts as a key determinant for proanthocyanidin accumulation in developing seed
    N Nesi
    Laboratoire de Biologie des Semences, Unite Mixte de Recherche, Institut National de la Recherche Agronomique, Centre de Versailles, Route de Saint Cyr, 78026 Versailles Cedex, France
    Plant Cell 13:2099-114. 2001
    ..Therefore, our results strongly suggest that stringent spatial and temporal BAN expression, and thus proanthocyanidin accumulation, are determined at least partially by TT2...
  57. pmc De novo transcriptome of safflower and the identification of putative genes for oleosin and the biosynthesis of flavonoids
    Haiyan Li
    Ministry of Education Engineering Research Center of Bioreactor and Pharmaceutical Development, Jilin Agricultural University, Changchun, Jilin, China
    PLoS ONE 7:e30987. 2012
    ..Metabolic pathway analysis revealed that 23 unigenes were predicted to be responsible for the biosynthesis of flavonoids and 8 were characterized as seed-specific oleosins...
  58. ncbi Antiproliferative activities of citrus flavonoids against six human cancer cell lines
    John A Manthey
    U S Citrus and Subtropical Products Laboratory, South Atlantic Area, Agricultural Research Service, U S Department of Agriculture, 600 Avenue S, N W, Winter Haven, Florida 33881, USA
    J Agric Food Chem 50:5837-43. 2002
    ..Glycosylation of these compounds removed their activity. The strong antiproliferative activities of the polymethoxylated flavones suggest that they may have use as anticancer agents in humans...
  59. ncbi Biological properties of citrus flavonoids pertaining to cancer and inflammation
    J A Manthey
    US Citrus and Subtropical Products Laboratory, USDA, ARS, SAA, 600 Avenue S, NW, Winter Haven, FL 33881, USA
    Curr Med Chem 8:135-53. 2001
    Citrus flavonoids encompass a diverse set of structures, including numerous flavanone and flavone O- and C-glycosides and methoxylated flavones...
  60. ncbi Differential combinatorial interactions of cis-acting elements recognized by R2R3-MYB, BZIP, and BHLH factors control light-responsive and tissue-specific activation of phenylpropanoid biosynthesis genes
    Ulrike Hartmann
    Department of Plant Breeding and Yield Physiology, Max Planck Institute for Plant Breeding Research, Carl von Linne Weg 10, D 50829 Köln, Germany
    Plant Mol Biol 57:155-71. 2005
    ..These data suggest that a BHLH and a R2R3-MYB factor cooperate in directing tissue-specific production of flavonoids, while an ACE-binding factor, potentially a BZIP, and a R2R3-MYB factor work together in conferring light ..
  61. ncbi Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas
    Mendel Friedman
    Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, Albany, CA, USA
    Mol Nutr Food Res 51:116-34. 2007
    ..This overview surveys and interprets our present knowledge of activities of tea flavonoids and teas against foodborne and other pathogenic bacteria, virulent protein toxins produced by some of the ..
  62. pmc MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula
    Jian Zhao
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
    Plant Cell 23:1536-55. 2011
    The majority of flavonoids, such as anthocyanins, proanthocyanidins, and isoflavones, are stored in the central vacuole, but the molecular basis of flavonoid transport is still poorly understood...
  63. ncbi Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
    Kavon Rezai-Zadeh
    Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 25:8807-14. 2005
    ..Recent studies suggest that green tea flavonoids may be used for the prevention and treatment of a variety of neurodegenerative diseases...
  64. ncbi Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signaling
    Cesar G Fraga
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires CONICET, Buenos Aires, Argentina
    Free Radic Biol Med 51:813-23. 2011
    ..Increasing evidence supports the health-promoting effects of certain polyphenols, including flavonoids. This review discusses current knowledge of the capacity of monomeric flavanols, i.e...
  65. pmc Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death
    Rong Chen
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 106:2513-9. 2005
    ..The dependence of CLL-cell survival on short-lived oncoproteins may provide the biochemical basis for the therapeutic index in response to flavopiridol...
  66. ncbi Anti-inflammatory activity of natural dietary flavonoids
    Min Hsiung Pan
    Department of Seafood Science, National Kaohsiung Marine University, No 142, Haijhuan Rd, Nanzih District, Kaohsiung, 81143, Taiwan
    Food Funct 1:15-31. 2010
    ..Targeting reduction of chronic inflammation is a beneficial strategy to combat several human diseases. Flavonoids are widely present in the average diet in such foods as fruits and vegetables, and have been demonstrated to ..
  67. ncbi Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties
    Giuseppe Galati
    Department of Pharmacology and Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    Free Radic Biol Med 37:287-303. 2004
    b>Flavonoids, including isoflavones, are natural components in our diet and, with the burgeoning interest in alternative medicine, are increasingly being ingested by the general population...
  68. ncbi Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
    Berrin Ozcelik
    Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Gazi University, Ankara, Turkey
    Pharm Biol 49:396-402. 2011
    ....
  69. ncbi Flavonoids and auxin transport: modulators or regulators?
    Wendy Ann Peer
    Department of Horticulture, 625 Agriculture Mall Drive, Purdue University, West Lafayette, IN 47906, USA
    Trends Plant Sci 12:556-63. 2007
    b>Flavonoids are polyphenolic compounds found in all vascular and non-vascular plants. Although nonessential for plant growth and development, flavonoids have species-specific roles in nodulation, fertility, defense and UV protection...
  70. ncbi Phenolic acid composition and antioxidant properties of Malaysian honeys
    M I Khalil
    Dept of Pharmacology, School of Medical Sciences, Univ Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    J Food Sci 76:C921-8. 2011
    ..Total of 6 phenolic acids (gallic, syringic, benzoic, trans-cinnamic, p-coumaric, and caffeic acids) and 5 flavonoids (catechin, kaempferol, naringenin, luteolin, and apigenin) were identified...
  71. ncbi Anti-inflammatory properties of dietary flavonoids
    J Gonzalez-Gallego
    Ciberehd and Institute of Biomedicine, University of Leon, Spain
    Nutr Hosp 22:287-93. 2007
    b>Flavonoids are a group of natural substances that are located in sources of vegetal origin. More than 4,000 varieties of flavonoids have been identified...
  72. ncbi Wine phenolics
    Andrew L Waterhouse
    Department of Viticulture and Enology, University of California, Davis, California 95616 8749, USA
    Ann N Y Acad Sci 957:21-36. 2002
    ..Wine phenolics include the non-flavonoids: hydroxycinnamates, hydroxybenzoates and the stilbenes; plus the flavonoids: flavan-3-ols, the flavonols, and ..
  73. pmc Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies
    Deniz Tasdemir
    Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Antimicrob Agents Chemother 50:1352-64. 2006
    ..Generally, the test compounds lacked cytotoxicity in vitro and in vivo. By screening a large number of flavonoids and analogues, we were able to establish some general trends with respect to the structure-activity relationship,..
  74. pmc A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways
    Yewseok Suh
    Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA
    Carcinogenesis 30:300-7. 2009
    ..We suggest that fisetin could be a useful agent for prevention and treatment of colon cancer...
  75. ncbi Flavonoids as antagonists at A1 adenosine receptors
    Stephen P H Alexander
    Institute of Neuroscience and School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK
    Phytother Res 20:1009-12. 2006
    ..binding assay for A(1) adenosine receptor occupancy in particulate preparations from guinea-pig cerebral cortex, flavonoids competed in concentration-dependent manners with Hill slopes typically not different from unity...
  76. ncbi Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells
    Hyon Seok Jang
    Department of Dentistry, Oral and Maxillofacial Surgery, College of Medicine, Korea University, Ansan 425 020, Korea
    Biochim Biophys Acta 1726:309-16. 2005
    Many studies have suggested that dietary flavonoids are anticancer agents that induce the apoptosis of cancer cells. However, the effects of flavonoids on the induction of apoptosis in osteosarcoma cells are unclear...
  77. ncbi Antioxidant activity of apple peels
    Kelly Wolfe
    Institute of Comparative and Environmental Toxicology and Department of Food Science, Stocking Hall, Cornell University, Ithaca, New York 14853 7201, USA
    J Agric Food Chem 51:609-14. 2003
    ..7 mg of gallic acid equivalents/100 g of peels, respectively). Rome Beauty and Idared peels were also highest in flavonoids (306.1 +/- 6.7 and 303.2 +/- 41.5 mg of catechin equivalents/100 g of peels, respectively)...
  78. pmc Arabidopsis mutants lacking phenolic sunscreens exhibit enhanced ultraviolet-B injury and oxidative damage
    L G Landry
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 1801, USA
    Plant Physiol 109:1159-66. 1995
    ..Arabidopsis mutants defective in the ability to synthesize UV-B-absorbing compounds (flavonoids in transparent testa 5 [tt5] and sinapate esters in ferulic acid hydroxylase 1 [fah1]) are more sensitive to UV-..
  79. ncbi Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption
    Alice Wattel
    Clinical Pharmacy Laboratory, Universite de Picardie Jules Verne, 1 rue des Louvels, 80000 Amiens, France
    Biochem Pharmacol 65:35-42. 2003
    ..The present study demonstrates that flavonols widely distributed in human diet such as quercetin and kaempferol, exert a potent inhibitory effect on in vitro bone resorption...
  80. ncbi Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by flavonoids from Astragalus complanatus
    Yan wei Hu
    Department of Pharmacology, Medical College of Soochow University, 199 RenAi Road, Suzhou 215123, PR China
    J Ethnopharmacol 123:293-301. 2009
    b>Flavonoids extracted from the seeds of Astragalus complanatus R.Br. reduce the proliferation of many cancer cells...
  81. ncbi Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines
    Wen Huei Chang
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan, R O C
    Planta Med 68:128-32. 2002
    The effects of the flavonoids from Scutellaria baicalensis Georgi (baicalein, baicalin and wogonin) in cultured human hepatoma cells (Hep G2, Hep 3B and SK-Hep1) were compared by MTT assay and flow cytometry...
  82. ncbi Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity
    O Benavente-García
    Research and Development Department of Nutrafur Furfural Español S A, Camino Viejo de Pliego s n, 80320 Alcantarilla, Murcia, Spain
    J Agric Food Chem 56:6185-205. 2008
    Significantly, much of the activity of Citrus flavonoids appears to impact blood and microvascular endothelial cells, and it is not surprising that the two main areas of research on the biological actions of Citrus flavonoids have been ..
  83. ncbi Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms
    Manjeet Singh
    INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, Quebec H7V 1B7, Canada
    J Agric Food Chem 56:4855-73. 2008
    ..The focus of this review is aimed at presenting the role of some polyphenols from fruits, vegetables, and beverages in neuroprotection and particularly in Alzheimer's disease and the research challenges in this area...
  84. ncbi Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
    Won Jun Lee
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
    Mol Pharmacol 68:1018-30. 2005
    ..The IC(50) values for catechin, epicatechin, and various flavonoids ranged from 1.0 to 8.4 microM, but EGCG was a more potent inhibitor, with IC(50) values ranging from 0.21 to 0...
  85. ncbi Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways
    Yue Li
    Department of New Drug Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, and Institute of Infectious Diseases, Beijing Ditan Hospital, No 1, Xian Nong Tan Street, Beijing 100050, China
    Eur J Pharmacol 640:46-54. 2010
    ..Chlorogenic acid and ginsenoside Rf only induced constitutive androstane receptor-mediated CYP3A4 expression...
  86. pmc Chemistry and biochemistry of dietary polyphenols
    Rong Tsao
    Guelph Food Research Centre, Agriculture and Agri Food Canada, Guelph Ontario, N1G 5C9, Canada
    Nutrients 2:1231-46. 2010
    ..The discussions are focused on important and most recent advances in the above aspects, and challenges are identified for future research...
  87. ncbi Neuroinflammation: modulation by flavonoids and mechanisms of action
    Jeremy P E Spencer
    Molecular Nutrition Group, Centre for Integrative Neuroscience and Neurodynamics, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK
    Mol Aspects Med 33:83-97. 2012
    ..Recently, there has been much interest in the potential neuroprotective effects of flavonoids, a group of plant secondary metabolites known to have diverse biological activity in vivo...
  88. ncbi Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity
    Mustafa Kassim
    Department of Anesthesiology, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Nutr Res 30:650-9. 2010
    ..1 and 235.4 μg/mL, respectively. In conclusion, HEAE exhibited greater activity in vitro, whereas HME contained a higher concentration of phenolic compounds per 100 g of honey...
  89. ncbi Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?
    Barry Halliwell
    Department of Biochemistry, Faculty of Medicine, Singapore
    Am J Clin Nutr 81:268S-276S. 2005
    Foods and beverages rich in phenolic compounds, especially flavonoids, have often been associated with decreased risk of developing several diseases...
  90. ncbi Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones
    Chenrui Li
    School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    Biopharm Drug Dispos 32:427-45. 2011
    ..It has been confirmed that flavonoids are the most abundant constituents and induce these therapeutic effects...
  91. pmc Variation in expression and protein localization of the PIN family of auxin efflux facilitator proteins in flavonoid mutants with altered auxin transport in Arabidopsis thaliana
    Wendy Ann Peer
    Department of Horticulture, Purdue University, West Lafayette, Indiana 47907 2010, USA
    Plant Cell 16:1898-911. 2004
    ..Biochemical studies suggest that flavonoids interact with regulatory proteins rather than directly with the PIN auxin efflux facilitator proteins...
  92. ncbi Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids
    Denise Wootten
    Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia
    J Pharmacol Exp Ther 336:540-50. 2011
    ..cells expressing the human GLP-1R, we have now extended this work to identify the structural requirements of flavonoids to modify GLP-1R binding and signaling (cAMP formation and intracellular Ca(2+) mobilization) of each of the GLP-..
  93. ncbi Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease
    Robert J Williams
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    Free Radic Biol Med 52:35-45. 2012
    ..In addition, a growing number of flavonoids have been shown to inhibit the development of Alzheimer disease (AD)-like pathology and to reverse deficits in ..
  94. ncbi Role of flavonoids in intestinal tight junction regulation
    Takuya Suzuki
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    J Nutr Biochem 22:401-8. 2011
    ..Dietary flavonoids demonstrate various beneficial effects on our health; however, the information regarding their effects on TJ ..
  95. pmc Identification of Baicalin as an immunoregulatory compound by controlling T(H)17 cell differentiation
    Ji Yang
    Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China
    PLoS ONE 6:e17164. 2011
    ..Our findings not only demonstrate that Baicalin could control T(H)17 cell differentiation but also suggest that Baicalin might be a promising therapeutic agent for the treatment of T(H)17 cells-mediated inflammatory diseases...
  96. ncbi Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C. elegans
    Gregor Grünz
    ZIEL Research Center of Nutrition and Food Sciences, Abteilung Biochemie, Technische Universitat Munchen, Gregor Mendel Strasse 2, Freising, Germany
    Mech Ageing Dev 133:1-10. 2012
    Various studies have demonstrated longevity effects of flavonoids, a major sub-group of plant polyphenolic compounds, in Caenorhabditis elegans...
  97. ncbi Antimicrobial activity of 10 different plant polyphenols against bacteria causing food-borne disease
    Toshitsugu Taguri
    Nagasaki Prefectural Institute of Public Health and Environmental Sciences, Japan
    Biol Pharm Bull 27:1965-9. 2004
    ..aureus (98-389 microg/ml) and the genus Vibrio (68-488 microg/ml) were similar. The relatively lower mean MIC values of 1, 2, 5, and 6 suggest the importance of 3,4,5-trihydroxyphenyl groups in antibacterial activity...
  98. ncbi Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease
    Tan Siew Kiat
    Sunway University College, Bandar Sunway, 46150, P J Selangor, Malaysia
    Bioorg Med Chem Lett 16:3337-40. 2006
    ..NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated...
  99. ncbi The relationship between phenolics and flavonoids production with total non structural carbohydrate and photosynthetic rate in Labisia pumila Benth. under high CO2 and nitrogen fertilization
    Mohd Hafiz Ibrahim
    Department of Crop Science, Faculty of Agriculture, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Molecules 16:162-74. 2011
    ..examine and characterize the relationship among production of secondary metabolites (total phenolics, TP; total flavonoids, TF), carbohydrate content and photosynthesis of three varieties of the Malaysian medicinal herb Labisia pumila ..
  100. ncbi Natural polyphenols that display anticancer properties through inhibition of kinase activity
    D Lamoral-Theys
    Laboratoire de Chimie Bioanalytique, Toxicologie et Chimie Physique Appliquee, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Curr Med Chem 17:812-25. 2010
    ..Lastly, a number of polyphenols are identified as potential antitumor agents that could be used to combat biologically aggressive cancers, including metastasizing cancers, through the targeting of specific kinases...
  101. ncbi In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids
    Prahlad Parajuli
    Department of Neurosurgery, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA
    Planta Med 75:41-8. 2009
    ..Scutellaria species and analyze their leaf, stem and root extracts for levels of common biologically active flavonoids: apigenin, baicalein, baicalin, chrysin, scutellarein, and wogonin...

Research Grants64

  1. SPECIES DIFFERENCE IN THE BIOTRANSFORMATION OF AFLATOXIN
    David Eaton; Fiscal Year: 2003
    ..In particular, specific chemical components of the diet, such as flavonoids, isocyanates, glucosinolates, indoles, dithiolthiones, and polyphenols have been identified as effective ..
  2. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..be beneficial, and our preliminary results indicate that only the tricyclic amitriptyline, and certain natural flavonoids can inhibit mast cell secretion and reduce intracellular calcium ion levels...
  3. Exploratory Studies on the Anti-Breast Cancer Function of Bamboo Extract
    Jun Panee; Fiscal Year: 2010
    ..The preliminary studies revealed that bamboo extract (BEX) contained a high level of flavonoids, and significantly enhanced the resistance of mammalian cells to varied oxidative stresses...
  4. Green tea effects on gene expression in tobacco users
    Joel L Schwartz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Green tea (GT) is a mixture largely of catechins, which are phenol flavonoids, and caffeine, that has shown efficacy in preventing lung cancer and a large host of other spontaneous and experimentally ..
  5. Novel neurotrophic therapy in a mouse model of ALS
    Alpaslan Dedeoglu; Fiscal Year: 2013
    ..7,8-dihydroxyflavone (7,8-DHF) is a member of the flavonoid family. Flavonoids, present in fruits and vegetables, have been shown to exert diverse biological actions including neuroprotective,..
  6. Effects of Cocoa Flavonols on Myocardial Infarction Size and Post-Injury Injury
    Francisco Villarreal; Fiscal Year: 2009
    ..Polyphenols are widely distributed in plants and are known as flavonoids. Evidence indicates a negative correlation between consumption of flavonoid-rich foods and incidence of ..
  7. Flavonoids, esophageal/gastric cardia adenocarcinoma and Barretts Esophagus Risk
    Marilie D Gammon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Flavonoids, esophageal/gastric cardia adenocarcinoma and Barrett's esophagus risk ABSTRACT...
  8. Biomaterials (Mf/Zn/F-BCPs) for osteoporosis therapy
    Yu Zhang; Fiscal Year: 2012
    ..the study is to develop novel innovative compounds, MZF-CaP and MZ- CaP/FF (a combination of MZ-CaP and flavan/flavonoids, FF), that will be safe, affordable and effective for prevention and reversal of bone loss...
  9. Prenatal diet, PM2.5 and programming of the infant autonomic response
    Rosalind J Wright; Fiscal Year: 2013
    ..g., ?-3 fatt acids and antioxidant micronutrients (e.g., vitamins C and E and flavonoids)] ascertained using a triad approach incorporating a food frequency questionnaire (FFQ), dietary records ..
  10. Alpha-Synuclein-Metal Complexes and Oxidative Stress in Parkinson's Disease
    Feimeng Zhou; Fiscal Year: 2012
    ..g., antioxidants such as flavonoids or PD risk factors such as herbicides) will also be conducted. A variety of analytical techniques (e.g...
  11. Identification and molecular characterization of anti-diabetic flavonoids
    Dongmin Liu; Fiscal Year: 2013
    ..S. and worldwide. ..
  12. Disposition of Flavonoids via Metabolic Interplay
    Ming Hu; Fiscal Year: 2012
    Dietary flavonoids are known to have a variety of health benefits, ranging from anticancer, antioxidant, antiosteoperosis and cholesterol lowering to anti-aging...
  13. Freeze-dried Fruit: Prevention and Rehabilitation Strategies in TBI
    Susan O McGuire; Fiscal Year: 2012
    ..Since berries contain high levels of the antioxidant flavonoids, particularly anthocyanins, and seem to possess beneficial immune modulatory and anti-inflammatory properties in ..
  14. Pooling of Prospective Studies of Diet, Lifestyle and ALS
    EILIS O'REILLY; Fiscal Year: 2013
    ..dietary aims of this project are to examine the relation between dietary intake of fatty acids, antioxidants and flavonoids, and fruit and vegetables with ALS...
  15. DIETARY ETIOLOGIES OF HEART DISEASE AND CANCER
    Eric B Rimm; Fiscal Year: 2013
    ..the risk of CHD and ischemic stroke associated with dietary antioxidants - specifically total dietary flavonoids (and 5 sub classes) and dietary pattern scores derived through principal component factor analyses...
  16. Molecular Epidemiology of NHL and CLL
    James R Cerhan; Fiscal Year: 2012
    ..energy balance (including obesity and physical activity), diet (including antioxidant-related nutrients and flavonoids), and farming/pesticide exposure (including farm practices and exposure to phenoxyacetic acid and triazine ..
  17. Urinary metabolites of cranberry that protect against bladder cancer
    Jeevan Kumar Prasain; Fiscal Year: 2010
    ..One such natural occurring fruit is cranberry. Cranberry fruits are rich in flavonoids and it is well known that cranberry juice is helpful in treating and preventing urinary tract infections (UTIs) ..
  18. DIETARY AND HORMONAL DETERMINANTS OF CANCER IN WOMEN
    Meir Stampfer; Fiscal Year: 2013
    ..incidence and survival will be assessed, in Project 3, we will evaluate vitamin D, melatonin, dietary factors (flavonoids, lactose and acrylamide) and plasma markers of inflammation in relation to ovarian cancer risk...
  19. Identification of Flavonoid Metabolites
    Jennifer S Brodbelt; Fiscal Year: 2010
    b>Flavonoids are a broad class of phenolic phytochemicals that exhibit chemopreventive properties in humans...
  20. Molecular Determinants for the Bioactivity of the Flavonoid Quercetin
    Temesgen Samuel; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Flavonoids constitute a group of polyphenolic compounds primarily known for their anti-oxidant properties...
  21. Cardioprotective Effects of Dietary Flavonoids in the Framingham Offspring Cohort
    Paul Jacques; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): There is a great deal of controversy about the potential effects of food flavonoids on cardiovascular disease risk...
  22. PYCNOGENOL AND TRAUMATIC BRAIN INJURY
    Stephen W Scheff; Fiscal Year: 2010
    ..Naturally occurring flavonoids are unique in possessing not only tremendous free radical scavenging properties but also the ability to modulate ..
  23. DRUG METABOLISM BY INTESTINAL FLAVIN MONOOXYGENASES
    ROSITA PROTEAU; Fiscal Year: 2001
    The opportunity for drug-dietary flavonoid interaction is an everyday occurrence whether the interaction is with flavonoids from food, juice, or dietary supplements...
  24. CONTROLLING NK CELL ANTI-CANCER ACTIVITY: THE ROLE OF NUTRIENTS AND SUPPLEMENTS
    Marco Colonna; Fiscal Year: 2013
    ..AHR is known to bind dietary compounds such as indol-3-carbinol (I3C) and flavonoids that are associated with anti-tumor activity...
  25. Structure/Function Studies of Quinone Reductase 2
    Zhongtao Zhang; Fiscal Year: 2009
    ..quinone reductase 2 (QR2) is the potential target of many natural polyphenols, including resveratrol analogs, flavonoids, chalconoids and some coumarin derivatives...
  26. Molecular Mechanisms and Application of Ah Receptor-MicroRNA Interactions
    Stephen H Safe; Fiscal Year: 2013
    ..AhR binds with structurally and functionally diverse compounds including chemoprotective phytochemicals such as flavonoids, polyphenolics and indole-3-carbinol...
  27. DiosMemTM, a natural gamma-secretase inhibitor, opposes AD pathogenesis
    Jun Tan; Fiscal Year: 2009
    ..In this light, recent focus has been given to a group of polyphenols categorized as flavonoids, which have been found to be potentially anti-amyloidogenic...
  28. Effects of Anthocyanins on Cytochrome P450 Enzymes and P-glycoprotein
    MICHAEL JOHN HANLEY; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Anthocyanins are a class of flavonoids found in many berry fruits, including blueberries...
  29. Concentrating anti-UTI phytochemicals from cranberry in a functional food matrix
    William May; Fiscal Year: 2012
    ..Nutrasorb technology, enables a rapid and streamlined one-step separation of the active health-beneficial flavonoids in cranberry (bioflavonoids) from other extraneous or high caloric components of cranberry juice, including ..
  30. Targeting cellular bioenergetics for the prevention and treatment of diabetes
    Francisco J Villarreal; Fiscal Year: 2011
    ..In spite of their therapeutic benefit they however, have the potential for serious side-effects. Flavonoids as TZDs have been reported to induce mitochondrial biogenesis favorably impacting cellular and organ ..
  31. Regulation of Wnt signal transduction by flavonoids.
    ALISON HANSON HANSON; Fiscal Year: 2010
    ..Accordingly, the anti-cancer effects of dietary flavonoids have become an increasing public health interest...
  32. Drug-Dietary Flavonoid Intestinal Absorption Interaction
    ROSITA PROTEAU; Fiscal Year: 2002
    ..Moreover, the consumption of flavonoids is being urged because of their multiple health benefits; thus, understanding the possible biological effects of ..
  33. Drug Interactions and Bioavailability of Cranberry
    Jennifer Donovan; Fiscal Year: 2005
    ..CB is a rich source of flavonoids, a class of phytochemicals with diverse biological activities...
  34. Taste psychophysics of bitter phytochemicals
    MIRIAM LINSCHOTEN; Fiscal Year: 2005
    ..Phytochemicals such as phenols, flavonoids, isoflavones, terpenes and glucosinolates have anti-oxidant and anti-carcinogenic properties and demonstrate a ..
  35. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..On the other hand, the cardio-protective effects of flavonoids result in part from their antioxidant properties, and their ability to modulate the activity of a wide spectrum ..
  36. Mechanistic analysis of flavonoids on bacterial virulence
    Howard C Hang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Flavonoids are major components of dietary supplements and herbal medicines with reported protective activities against microbial infections in humans...
  37. ELECTRON PARAMAGNETIC RESONANCE SPECTROMETER
    Cecilia Giulivi; Fiscal Year: 2009
    ..in several areas as follows: a) fundamental chemistry and biochemistry of antioxidants such as vitamin E, C and flavonoids;b) biochemistry of NO production in mosquito vectors of malaria parasites and the putative antiparasite role of ..
  38. DISPOSITION OF GINKGO FLAVONOIDS VIA RECYCLING
    Ming Hu; Fiscal Year: 2001
    ..This sequential metabolism of ginkgo-flavones is expected to be efficient and extensive, because flavonoids and their metabolites are expected to go through repeated enterohepatic recycling...
  39. BREAST CANCER IN WOMEN OF POLISH ANCESTRY
    Dorothy Pathak; Fiscal Year: 2001
    ..g. glucobrassicins, carotenoids, flavonoids, and antioxidants), and dietary fiber; and 3) increase in intake of meat, meat products and dietary fat; and 4) ..
  40. BREAST CANCER IN WOMEN OF POLISH ANCESTRY
    Dorothy Pathak; Fiscal Year: 1999
    ..g. glucobrassicins, carotenoids, flavonoids, and antioxidants), and dietary fiber; and 3) increase in intake of meat, meat products and dietary fat; and 4) ..
  41. POTENTIAL FETOPROTECTANTS FROM ETOH-INDUCED STRESS
    Linda La Grange; Fiscal Year: 2000
    ..We now want to test the antioxidant effects of SY and four other antioxidant flavonoids; quercetin, myricetin, (+)-catechin, and apigenin on EtOH-exposed fetal rat brain and liver tissue...
  42. CARBON-13 MAGNETIC RESONANCE - METHODS AND THEORY
    DAVID MORRIS GRANT; Fiscal Year: 2010
    ..The applications include drug and pharmaceutical agents, several antioxidant flavonoids. Specifically, we have made considerable progress in the structure of Taxol...
  43. Cardiovascular Effects of Scutellaria baicelensis
    Chun Su Yuan; Fiscal Year: 2002
    ..Thus, we hypothesize that flavonoids of Scutellaria baicalensis have significant antioxidant potential, and they regulate the concentration of ..
  44. Cancer Chemoprevention by Pomegranate Fruit Extract
    Farrukh Afaq; Fiscal Year: 2006
    ..However, the search for ideal agent(s) for the armamentarium of photochemoprevention continues. Plant-based flavonoids, a group of polyphenolic compounds, are showing promise as useful chemo- preventive and chemotherapeutic agents...
  45. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2004
    ..of trans-acting factors at multiple and redundant regulatory elements, and that naturally-occurring dietary flavonoids alter the expression of both CYP 1 A2 and CYP IA 1...
  46. DIFFERENTIATION AND APOPTOSIS IN MALIGNANT NEUROBLASTOMA
    Swapan Ray; Fiscal Year: 2009
    ..Also, flavonoids, such as apigenin (APG), (-)-epigallocatechin (EGG), (-)-epigallocatechin-3-gallate (EGCG), and genistein (GST), ..
  47. Complementary treatment approach to epilepsy
    Siegward Elsas; Fiscal Year: 2009
    ..The popular botanical Passionflower is commonly used by epilepsy patients. Passionflower flavonoids have been found to prevent pentylenetetrazol-induced seizures and to activate inhibitory GABA currents in animal ..
  48. Evolutionary genetics of flower color in lochroma (Solanaceae)
    Stacey Smith; Fiscal Year: 2009
    ..Color differences among lochroma species are largely due to differences in anthocyanin pigments, a class of flavonoids. The proposed research will investigate the genetic changes in the anthocyanin pathway responsible for the ..
  49. FLAVONOIDS BLOCK SULFATION-INDUCED CARCINOGEN ACTIVATION
    Thomas Walle; Fiscal Year: 1999
    ..The hypothesis is that flavonoids in plant food and beverages are potent inhibitors of human sulfotransferases (STs), enzymes known to catalyze ..
  50. MDR1 IN HUMAN INTESTINE
    Kenneth Lown; Fiscal Year: 1999
    ..volunteers on diets containing charcoal broiled beef or, in collaboration with Paul Watkins, grapefruit juice (flavonoids)...
  51. Analysis of Phenolic Phytochemical by ESI-MS
    Jennifer Brodbelt; Fiscal Year: 2003
    ..be aimed at solving specific problems from four collaborations: one involving the detection and quantitation of flavonoids in kale, soy, and urine, the second involving the identification and quantitation of coumarins in urine and ..
  52. FUNCTION OF HYDROXYLASES AND OTHER OXIDATIVE
    Minor Coon; Fiscal Year: 1993
    ..obtained the predicted sequence from an isolated gene (P-450z) and other P-450's that are induced by clofibrate, flavonoids, cholestyramine, debrisoquine, or starvation, are sex-specific, or are responsible for the oxygenation of ..
  53. Interaction Between Irinotecan and Dietary Flavonoids
    Lalitha Iyer; Fiscal Year: 2004
    ..interaction between the anticancer agent irinotecan (used against colorectal cancer) and the popular dietary flavonoids from soy (genistein and daidzein) and fruits and vegetables (chrysin and quercetin)...
  54. Flavonoid Modulation of Epithelial Migration and Signal*
    NORMAN HORD; Fiscal Year: 2004
    ..The objective of this application is to identify the intracellular signaling pathways induced by flavonoids that contribute to cell migration...
  55. FLAVONOIDS AND CARDIOVASCULAR DISEASE
    Howard Sesso; Fiscal Year: 2000
    ..and epidemiologic studies have all contributed to an emerging body of evidence on the potential role of flavonoids, a group of polyphenolic compounds with antioxidant properties, in the prevention of CVD...
  56. UCLA CENTER FOR DIETARY SUPPLEMENTS RESEARCH: BOTANICALS
    David Heber; Fiscal Year: 2004
    ..John's Wort), four Pilot Studies (Echinacea, Flavonoids, Soy Isoflavones, and Plant Phytoestrogens, and three Scientific Cores in Agriculture and Botany, Analytic ..
  57. Cranberry flavonoids and cardiovascular inflammation
    Jess Reed; Fiscal Year: 2006
    ..Cranberries are a dietary source of flavonoids which may decrease inflammation and atherosclerosis...
  58. Neuromodulatory Effects of Ginkgolides and Bilobalide
    Koji Nakanishi; Fiscal Year: 2007
    ..g., between the flavonoids (a major component) and the terpenoid trilactones...
  59. FUNCTION OF HYDROXYLASES AND OTHER OXIDATIVE ENZYMES
    Minor Coon; Fiscal Year: 2002
    ..be examined that the levels of the oxidants are subject to regulation by effectors, including cytochrome b5 and flavonoids. 2...
  60. Green Tea Anticancer Mechanisms in Smokers
    Philip Diaz; Fiscal Year: 2009
    ..Project end points relate to defenses against cancer development, and have shown changes due to green tea or its flavonoids in animals and/or in vitro, and can be measured in BAL samples, and in most cases, have shown abnormal BAL ..
  61. FLAVONOIDS AND DIFFERENTIAL GENE EXPRESSION
    Cecil Joseph; Fiscal Year: 2001
    b>Flavonoids are phenolic compounds that are widely distributed in higher plants and form part of the human diet...
  62. GREEN TEA CONSUMPTION AND CORONARY HEART DISEASE
    Boji Huang; Fiscal Year: 1999
    ..Both in vivo and in vitro experiments have show that flavonoids, antioxidants which are rich in green tea, are potentially as beneficial as vitamin E, beta-carotene and vitamin ..
  63. GENISTEIN AS MODULATOR OF ANTIOXIDANT PROTEIN EXPRESSION
    Shiu Ming Kuo; Fiscal Year: 2002
    b>Flavonoids represent a family of phytochemicals found in many human food items. Among them, genistein (Gn) is found especially at high concentration in soybeans, an important element of Oriental diet...
  64. REGULATION OF IGE EXPRESSION
    TOVA FRANCUS; Fiscal Year: 1990
    b>Flavonoids and other polyphenols are ubiquitous in plants including edible fruits, vegetables and tobacco. Free polyphenols have been known to affect a number of biochemical processes...