catechin

Summary

Summary: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.

Top Publications

  1. ncbi EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
    Dagmar E Ehrnhoefer
    Max Delbrueck Center for Molecular Medicine, AG Neuroproteomics, 13092 Berlin, Germany
    Nat Struct Mol Biol 15:558-66. 2008
  2. pmc Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
    Brahma N Singh
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, KS 66160, United States
    Biochem Pharmacol 82:1807-21. 2011
  3. pmc Identification of catechin as one of the flavonoids from Combretum albiflorum bark extract that reduces the production of quorum-sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1
    Olivier M Vandeputte
    Plant Biotechnology Unit, BioVallée, 8 rue Adrienne Bolland, B 6041 Gosselies, Belgium
    Appl Environ Microbiol 76:243-53. 2010
  4. pmc Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
    Chung S Yang
    Susan Lehman Cullman Laboratory of Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Nat Rev Cancer 9:429-39. 2009
  5. pmc EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity
    Jan Bieschke
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 107:7710-5. 2010
  6. ncbi Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 43:89-143. 2003
  7. ncbi Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    Ming Zhu Fang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Cancer Res 63:7563-70. 2003
  8. ncbi Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
    Sonia Ramos
    Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain
    J Nutr Biochem 18:427-42. 2007
  9. pmc The tea catechin epigallocatechin gallate suppresses cariogenic virulence factors of Streptococcus mutans
    Xin Xu
    Department of Pediatric Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    Antimicrob Agents Chemother 55:1229-36. 2011
  10. ncbi Inhibition of carcinogenesis by tea
    Chung S Yang
    Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Annu Rev Pharmacol Toxicol 42:25-54. 2002

Detail Information

Publications383 found, 100 shown here

  1. ncbi EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
    Dagmar E Ehrnhoefer
    Max Delbrueck Center for Molecular Medicine, AG Neuroproteomics, 13092 Berlin, Germany
    Nat Struct Mol Biol 15:558-66. 2008
    ..Instead of beta-sheet-rich amyloid, the formation of unstructured, nontoxic alpha-synuclein and amyloid-beta oligomers of a new type is promoted, suggesting a generic effect on aggregation pathways in neurodegenerative diseases...
  2. pmc Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
    Brahma N Singh
    Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, KS 66160, United States
    Biochem Pharmacol 82:1807-21. 2011
    An expanding body of preclinical evidence suggests EGCG, the major catechin found in green tea (Camellia sinensis), has the potential to impact a variety of human diseases...
  3. pmc Identification of catechin as one of the flavonoids from Combretum albiflorum bark extract that reduces the production of quorum-sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1
    Olivier M Vandeputte
    Plant Biotechnology Unit, BioVallée, 8 rue Adrienne Bolland, B 6041 Gosselies, Belgium
    Appl Environ Microbiol 76:243-53. 2010
    ..and structural characterization of one of the active compounds led to the identification of the flavan-3-ol catechin [(2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol]...
  4. pmc Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
    Chung S Yang
    Susan Lehman Cullman Laboratory of Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Nat Rev Cancer 9:429-39. 2009
    ..Here, we review these biological activities and existing data relating tea consumption to human cancer risk in an attempt to understand the potential use of tea for cancer prevention...
  5. pmc EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity
    Jan Bieschke
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 107:7710-5. 2010
    ..These findings suggest that EGCG is a potent remodeling agent of mature amyloid fibrils...
  6. ncbi Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 43:89-143. 2003
    ..Larger human studies examining the effects of tea and tea catechin intake on biomarkers of oxidative damage to lipids, proteins, and DNA are needed.
  7. ncbi Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    Ming Zhu Fang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Cancer Res 63:7563-70. 2003
    ....
  8. ncbi Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
    Sonia Ramos
    Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain
    J Nutr Biochem 18:427-42. 2007
    ....
  9. pmc The tea catechin epigallocatechin gallate suppresses cariogenic virulence factors of Streptococcus mutans
    Xin Xu
    Department of Pediatric Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    Antimicrob Agents Chemother 55:1229-36. 2011
    ..6 and 31.25 μg/ml). These findings suggest that EGCg is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity...
  10. ncbi Inhibition of carcinogenesis by tea
    Chung S Yang
    Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Annu Rev Pharmacol Toxicol 42:25-54. 2002
    ..These mechanisms need to be evaluated and verified in animal models or humans in order to gain more understanding on the effect of tea consumption on human cancer...
  11. ncbi Beneficial effects of green tea--a review
    Carmen Cabrera
    Departamento de Nutricion y Bromatologia, Facultad de Farmacia, Campus Universitario de Granada, Granada, Spain
    J Am Coll Nutr 25:79-99. 2006
    ....
  12. ncbi Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
    Carlo Stresemann
    Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 66:2794-800. 2006
    ..These results show a substantial diversity in the molecular activities of DNA methyltransferase inhibitors and provide valuable insights into the developmental potential of individual drugs...
  13. ncbi Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
    Kavon Rezai-Zadeh
    Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 25:8807-14. 2005
    ..These data raise the possibility that EGCG dietary supplementation may provide effective prophylaxis for AD...
  14. ncbi Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study
    Saverio Bettuzzi
    Department of Medicina Sperimentale, Sezione di Biochimica, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Cancer Res 66:1234-40. 2006
    ..As a secondary observation, administration of GTCs also reduced lower urinary tract symptoms, suggesting that these compounds might also be of help for treating the symptoms of benign prostate hyperplasia...
  15. ncbi Antiviral effect of catechins in green tea on influenza virus
    Jae Min Song
    Department of Biotechnology, College of Engineering, Yonsei University, 134, Shinchon dong, Seodaemun gu, Seoul 120 749, South Korea
    Antiviral Res 68:66-74. 2005
    ..The results show that the 3-galloyl group of catechin skeleton plays an important role on the observed antiviral activity, whereas the 5'-OH at the trihydroxy benzyl ..
  16. ncbi Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells
    Claudia Kürbitz
    Division of Molecular Oncology, Institute of Experimental Cancer Research, CCC North, Kiel, Germany
    Cancer Sci 102:728-34. 2011
    ..The best studied catechin and the major polyphenol present in green tea is epigallocatechin gallate (EGCG)...
  17. ncbi Comparative effects of EGCG, green tea and a nutrient mixture on the patterns of MMP-2 and MMP-9 expression in cancer cell lines
    M W Roomi
    Dr Rath Research Institute, Santa Clara, CA 95050, USA
    Oncol Rep 24:747-57. 2010
    ..In conclusion, these results suggest the enhanced efficacy of nutrients working in synergy to modulate complex pathways such as MMP expression...
  18. ncbi Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis
    De Yu Xie
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Science 299:396-9. 2003
    ..Ectopic expression of BAN in tobacco flower petals and Arabidopsis leaves results in loss of anthocyanins and accumulation of CTs...
  19. ncbi Green tea and green tea catechin extracts: an overview of the clinical evidence
    Rachel Johnson
    Centre for Academic Primary Care, NIHR School for Primary Care Research, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Maturitas 73:280-7. 2012
    ..The aim was to produce an overview of the evidence for green tea for these three important health conditions...
  20. pmc The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention
    Joshua D Lambert
    Department of Food Science, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 501:65-72. 2010
    ..This review is meant point out understudied areas and stimulate research on the topic with the hope that insights into the mechanisms of cancer preventive activity of tea polyphenols will result...
  21. ncbi The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site
    Masanori Miyata
    Department of Molecular Medicine, Global COE Cell Fate Regulation Research and Education Unit, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Biochemistry 49:6104-14. 2010
    ..Taken together, these findings suggest the possibility that EGCG may be a candidate compound for FAP therapy...
  22. ncbi Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation
    Nelson Ferreira
    Grupo de Neurobiologia Molecular, IBMC Instituto de Biologia Molecular e Celular, Porto, Portugal
    FEBS Lett 585:2424-30. 2011
    ..Our studies, together with the safe toxicological profile of these phytochemicals may guide a novel pharmacotherapy for TTR-related amyloidosis targeting different steps in fibrillogenesis...
  23. ncbi Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate
    Naghma Khan
    Department of Dermatology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 66:2500-5. 2006
    ..This review discusses the modulations of important signaling events by EGCG and their implications in cancer management...
  24. ncbi Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans
    A G Dulloo
    Department of Physiology, Faculty of Medicine, University of Geneva
    Am J Clin Nutr 70:1040-5. 1999
    ..Current interest in the role of functional foods in weight control has focused on plant ingredients capable of interfering with the sympathoadrenal system...
  25. ncbi Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome
    Arpita Basu
    Nutritional Sciences, Human Environmental Sciences, Oklahoma State University, Stillwater, Oklahoma, USA
    J Am Coll Nutr 29:31-40. 2010
    ..To compare the effects of supplementation of green tea beverage or green tea extracts with controls on body weight, glucose and lipid profile, biomarkers of oxidative stress, and safety parameters in obese subjects with metabolic syndrome...
  26. ncbi Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways
    C C Wu
    Institute of Biotechnology, National Chiayi University, Chiayi, Taiwan
    Life Sci 78:2889-97. 2006
    ..Hence, EGCG is a novel phytochemical inducer of HO-1 expression and we further identify the principal underlying mechanisms involved in this process...
  27. pmc Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate
    Imtiaz A Siddiqui
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Cancer Res 69:1712-6. 2009
    ..Thus, this study could serve as a basis for the use of nanoparticle-mediated delivery to enhance bioavailability and limit any unwanted toxicity of chemopreventive agents, such as EGCG...
  28. ncbi Epigallocatechin gallate supplementation alleviates diabetes in rodents
    Swen Wolfram
    DSM Nutritional Products Ltd, Department of Human Nutrition and Health, CH 4002 Basel, Switzerland
    J Nutr 136:2512-8. 2006
    ..This study investigated the antidiabetic effects of the most abundant green tea catechin, epigallocatechin gallate (EGCG, TEAVIGO), in rodent models of type 2 diabetes mellitus and H4IIE rat hepatoma ..
  29. ncbi Molecular targets of (-)-epigallocatechin-3-gallate (EGCG): specificity and interaction with membrane lipid rafts
    S K Patra
    Department of Experimental Medicine, University of Parma, Parma, Italy
    J Physiol Pharmacol 59:217-35. 2008
    ..We suggest here that the anticancer activity of Green Tea Catechins against different kind of cancers may find an explanation in direct targeting of lipid rafts by EGCG...
  30. ncbi The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis
    R Hursel
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Obes Rev 12:e573-81. 2011
    Different outcomes of the effect of catechin-caffeine mixtures and caffeine-only supplementation on energy expenditure and fat oxidation have been reported in short-term studies...
  31. ncbi Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice
    George L Tipoe
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR
    Toxicology 273:45-52. 2010
    ..The protective effect of EGCG may in part be a consequence of the reduction in oxidative stress and the pro-inflammatory response...
  32. ncbi Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
    Kavon Rezai-Zadeh
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, and Department of Neurosurgery, University of South Florida, Tampa, FL 33613, USA
    Brain Res 1214:177-87. 2008
    ..Taken together, these data further the notion of EGCG dietary supplementation as a potentially safe and effective prophylaxis for Alzheimer's disease...
  33. ncbi Effects of green tea and EGCG on cardiovascular and metabolic health
    Swen Wolfram
    DSM Nutritional Products Ltd, Department of Human Nutrition and Health, P O Box 3255, Bldg 241 425, CH 4002 Basel, Switzerland
    J Am Coll Nutr 26:373S-388S. 2007
    ..scientists throughout the world have investigated the potential benefits of green tea and its most abundant catechin, epigallocatechin gallate (EGCG)...
  34. ncbi Hydrogen peroxide mediates EGCG-induced antioxidant protection in human keratinocytes
    Leonilla Elbling
    Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria
    Free Radic Biol Med 49:1444-52. 2010
    The beneficial health effects of (-)-epigallocatechin-3-gallate (EGCG), the main catechin of green tea, have been attributed to complex interactions with a focus on antioxidative properties...
  35. ncbi Extract of lotus leaf ( Nelumbo nucifera ) and its active constituent catechin with insulin secretagogue activity
    Chun Fa Huang
    Graduate Institute of Chinese Medical Science, School of Chinese Medicine, College of Chinese Medicine, China
    J Agric Food Chem 59:1087-94. 2011
    ..Furthermore, the in vitro and in vivo effects of the active constituents of NNE, quercetin, and catechin, on glucose-induced insulin secretion and blood glucose regulation were evaluated...
  36. pmc Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro
    Guang Xun Li
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 31:902-10. 2010
    ..Although EGCG is generally considered to be an antioxidant, the present study demonstrates the pro-oxidative activities of EGCG in vivo and in vitro in the described experimental system...
  37. pmc The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice
    Mousumi Bose
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Nutr 138:1677-83. 2008
    ..Short-term EGCG treatment appeared to reverse preexisting high-fat-induced metabolic pathologies in obese mice. These effects may be mediated by decreased lipid absorption, decreased inflammation, and other mechanisms...
  38. ncbi Inhibitory effect of catechin against the superantigen staphylococcal enterotoxin B (SEB)
    Michi Hisano
    Department of Microbiology and Immunology, Showa University School of Medicine, 1 5 8, Hatanodai, Shinagawa ku, 142 8555 Tokyo, Japan
    Arch Dermatol Res 295:183-9. 2003
    ..Tea catechin has been found to have many unique antimicrobiological activities such as antibacterial, antiviral, antifungal ..
  39. ncbi (-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78
    Svetlana P Ermakova
    Hormel Institute, University of Minnesota, Austin, Minnesota
    Cancer Res 66:9260-9. 2006
    ....
  40. ncbi Insights into the putative catechin and epicatechin transport across blood-brain barrier
    Ana Faria
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Al Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Food Funct 2:39-44. 2011
    ..The aim of this work was to evaluate the transmembrane transport of catechin and epicatechin across blood-brain barrier (BBB)...
  41. ncbi Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study
    Masatomo Hirasawa
    Department of Microbiology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba Japan
    J Periodontal Res 37:433-8. 2002
    The purpose of this study was to determine the usefulness of green tea catechin for the improvement of periodontal disease...
  42. ncbi EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR
    Maria A Potenza
    Departments of Pharmacology and Human Physiology, Medical School, University of Bari, 70124 Bari, Italy
    Am J Physiol Endocrinol Metab 292:E1378-87. 2007
    ..These findings may be relevant to understanding potential benefits of green tea consumption in patients with the metabolic syndrome...
  43. ncbi A receptor for green tea polyphenol EGCG
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Nat Struct Mol Biol 11:380-1. 2004
    ..Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K (d) value...
  44. ncbi Green tea extract and (-)-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities
    Leonilla Elbling
    Institute of Cancer Research, Division of Applied and Experimental Oncology, Medical University of Vienna, Borschkegasse 8a, Vienna 1090, Austria
    FASEB J 19:807-9. 2005
    ....
  45. ncbi Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice
    Jae Woong Lee
    College of Pharmacy, Chungbuk National University 12, Gaesin dong, Heungduk gu, Cheongju, Chungbuk 361 763, Korea
    J Nutr 139:1987-93. 2009
    ..Moreover, EGCG inhibited the fibrillization of Abeta in vitro with a half maximal inhibitory concentration of 7.5 mg/L. These studies suggest that EGCG may be a beneficial agent in the prevention of development or progression of AD...
  46. ncbi A green tea extract high in catechins reduces body fat and cardiovascular risks in humans
    Tomonori Nagao
    Health Care Food Research Laboratories, Kao Corporation, 2 1 3, Bunka, Sumida ku, Tokyo, 131 8501, Japan
    Obesity (Silver Spring) 15:1473-83. 2007
    ..The body fat reducing effect and reduction of risks for cardiovascular disease by a green tea extract (GTE) high in catechins was investigated in humans with typical lifestyles...
  47. pmc Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components
    Y Li
    Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Med Chem 17:2141-51. 2010
    ....
  48. ncbi The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6
    F Yang
    Graduate Program in Nutritional Sciences, University of Kentucky and Veterans Administration Medical Center, Lexington, Kentucky, USA
    Mol Pharmacol 60:528-33. 2001
    ..In conclusion, EGCG is an effective inhibitor of IKK activity. This may explain, at least in part, some of the reported anti-inflammatory and anticancer effects of green tea...
  49. pmc Multitargeted therapy of cancer by green tea polyphenols
    Naghma Khan
    Department of Dermatology, University of Wisconsin Madison, Medical Sciences Center, B 25, 1300 University Avenue, Madison, WI 53706, USA
    Cancer Lett 269:269-80. 2008
    ..It has become clear that much of these effects of GTP are mediated by its most abundant catechin, epigallocatechin gallate (EGCG)...
  50. ncbi Potential role of green tea catechins in various disease therapies: progress and promise
    Judith C W Mak
    Departments of Medicine and Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China
    Clin Exp Pharmacol Physiol 39:265-73. 2012
    ....
  51. ncbi Role of hydrogen peroxide in bactericidal action of catechin
    Hidetoshi Arakawa
    School of Pharmaceutical Sciences, Department of Analytical Chemistry, Showa University, Tokyo, Japan
    Biol Pharm Bull 27:277-81. 2004
    b>Catechin (epicatechin (EC), epicatechin gallate (ECg), epigallocatechin (EGC) and epigallocatechin gallate (EGCg)), which occur in green tea and black tea, possess strong bactericidal action...
  52. ncbi Tea polyphenols: prevention of cancer and optimizing health
    H Mukhtar
    Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Clin Nutr 71:1698S-702S; discussion 1703S-4S. 2000
    ..This "designer-item" approach may be useful for human populations, but it requires further study...
  53. pmc Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells
    Di Chen
    the Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, and Department of Oncology, School of Medicine, Wayne State University, 540 1 HWCRC, 4100 John R Road, Detroit, MI 48201 2013, USA
    Bioorg Med Chem 20:3031-7. 2012
    ..Our findings suggest that novel potent and specific AMPK activators can be discovered from natural and synthetic sources that have potential to be used for anti-cancer therapy in the clinic...
  54. ncbi Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid
    Yusuf Yilmaz
    Department of Food Science and Technology, The University of Georgia, Athens, Georgia 30602 7610, USA
    J Agric Food Chem 52:255-60. 2004
    Grape seeds and skins are good sources of phytochemicals such as gallic acid, catechin, and epicatechin and are suitable raw materials for the production of antioxidative dietary supplements...
  55. ncbi Effects of catechin enriched green tea on body composition
    Hongqiang Wang
    Unilever R and D, Shanghai, China
    Obesity (Silver Spring) 18:773-9. 2010
    ..This experiment was therefore undertaken to study the effects of a high-catechin GT on body composition in a moderately overweight Chinese population...
  56. pmc Apoptosis by dietary agents for prevention and treatment of prostate cancer
    Naghma Khan
    Department of Dermatology, Medical Sciences Center, University of Wisconsin Madison, 4385, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Endocr Relat Cancer 17:R39-52. 2010
    ..In this article, we highlight the studies of various apoptosis-inducing dietary compounds for prevention of PCa in vitro in cell culture, in preclinical studies in animals, and in human clinical trials...
  57. ncbi Protection of ascorbic acid from copper(II)-catalyzed oxidative degradation in the presence of flavonoids: quercetin, catechin and morin
    Bılge Yildoğan Beker
    Yildiz Technical University, Science and Arts Faculty, Chemistry Department, Esenler 34010, Istanbul, Turkey
    Int J Food Sci Nutr 62:504-12. 2011
    ..1 ionic strength (KNO(3)); the effects of three different flavonoids of similar structure (quercetin, morin and catechin) and their mixtures on the AA system were studied...
  58. ncbi Epicatechin inhibits radiation-induced auditory cell death by suppression of reactive oxygen species generation
    J H Pyun
    Department of Otolaryngology, School of Medicine, Ajou University, Suwon, Korea
    Neuroscience 199:410-20. 2011
    ..The results of this study suggest that EC significantly inhibited radiation-induced apoptosis in auditory hair cells and may be a safe and effective candidate treatment for the prevention of radiation-induced ototoxicity...
  59. ncbi Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation
    S Klaus
    Group of Energy Metabolism, German Institute of Human Nutrition in Potsdam, Nuthetal, Germany
    Int J Obes (Lond) 29:615-23. 2005
    ..To examine the antiobesity effect of epigallocatechin gallate (EGCG), a green tea bioactive polyphenol in a mouse model of diet-induced obesity...
  60. ncbi (-)-Epigallocatechin gallate suppresses proliferation of vascular smooth muscle cells induced by high glucose by inhibition of PKC and ERK1/2 signalings
    Jian Yang
    Department of Nutrition, Daping Hospital, The Third Military Medical University, Chongqing, 400042 People s Republic of China
    J Agric Food Chem 59:11483-90. 2011
    ..Epigallocatechin gallate (EGCG), the major catechin derived from green tea, is able to exert antidiabetes effects in animal models...
  61. ncbi Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea
    Jihyeung Ju
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Cancer Res 65:10623-31. 2005
    ....
  62. ncbi Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells
    Catalina Carrasco-Pozo
    Laboratory of Microbiology and Probiotics, Institute of Nutrition and Food Technology, University of Chile, Av Macul 5540, Santiago, P O Box 138 11, Chile
    Chem Biol Interact 195:199-205. 2012
    ..This new role might expand the preventive and/or therapeutic use of PPs in conditions involving mitochondrial dysfunction and associated with increased oxidative stress at the cellular or tissue levels...
  63. ncbi Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis
    Olivia J Phung
    University of Connecticut School of Pharmacy, Storrs, CT, USA
    Am J Clin Nutr 91:73-81. 2010
    ..Green tea catechins (GTCs) with or without caffeine have been studied in randomized controlled trials (RCTs) for their effect on anthropometric measures and have yielded conflicting results...
  64. ncbi Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Nutr Biochem 16:610-6. 2005
    ..In future studies of dietary effects on the plasma antioxidant capacity, changes in plasma uric acid will need to be closely monitored...
  65. ncbi EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells
    Chi Hung Huang
    Institute of Biochemistry, College of Life Science, National Chung Hsing University, Taichung, Taiwan
    Mol Nutr Food Res 53:1156-65. 2009
    ..However, EGCG inducted apoptosis in p53 negative Hep 3B cells. Based on these results, we have demonstrated that EGCG has a potential to be a chemoprevention and anti-lipogenesis agent for human hepatoma cells...
  66. ncbi (-)-Epigallocatechin gallate, the most active polyphenolic catechin in green tea, presynaptically facilitates Ca2+-dependent glutamate release via activation of protein kinase C in rat cerebral cortex
    Chien Wen Chou
    Chi Mei Foundation Medical Center, Yung Kang City, Tainan, Taiwan
    Synapse 61:889-902. 2007
    ....
  67. ncbi Positive inotropic effect of purified green tea catechin derivative in guinea pig hearts: the measurements of cellular Ca2+ and nitric oxide release
    Yoshihiro Hotta
    Department of Pharmacology, Aichi Medical University School of Medicine, Aichi 480 1195, Japan
    Eur J Pharmacol 552:123-30. 2006
    Each individual and pure catechin isolated from green tea was investigated as to its myocardial or blood pressure effects...
  68. ncbi Preventive effects of green tea catechins on spontaneous stroke in rats
    Masahiko Ikeda
    College of Environment and Disaster Research, Fuji Tokoha University, Ohbuchi, Fuji, Shizuoka, Japan
    Med Sci Monit 13:BR40-5. 2007
    ..In this study, we examined whether tea catechin intake decreases the incidence of spontaneous stroke in M-SHRSP.
  69. ncbi Attenuation of liver ischemia/reperfusion induced apoptosis by epigallocatechin-3-gallate via down-regulation of NF-kappaB and c-Jun expression
    Dimitrios E Giakoustidis
    Department of Transplant Surgery, Medical School, Aristotle University and Hippokration General Hospital, Thessaloniki, Greece
    J Surg Res 159:720-8. 2010
    ....
  70. ncbi Highly antibiotic-resistant Acinetobacter baumannii clinical isolates are killed by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)
    A Osterburg
    Shriners Hospitals for Children, Cincinnati, OH, USA
    Clin Microbiol Infect 15:341-6. 2009
    ..EGCG has previously been shown to be safe, and therefore may be an attractive addition for the treatment of cutaneous A. baumannii infections where high concentrations of the drug can be applied to the wound surface...
  71. ncbi Interaction of (-)-epigallocatechin-3-gallate with human serum albumin: fluorescence, fourier transform infrared, circular dichroism, and docking studies
    Tushar Kanti Maiti
    Department of Chemistry, Indian Institute of Technology, Kharagpur, India
    Proteins 64:355-62. 2006
    ..We have also looked at changes in the accessible surface area of the interacting residues on binding EGCG for a better understanding of the interaction...
  72. ncbi Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1
    Jung Hyun Shim
    The Hormel Institute, University of Minnesota, Austin, MN 55912 3679, USA
    Cancer Prev Res (Phila) 3:670-9. 2010
    ..Overall, these results strongly indicate that EGCG suppresses lung tumorigenesis through its binding with G3BP1...
  73. ncbi Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn
    Jeong A Kim
    Diabetes Unit, NCCAM, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:13736-45. 2007
    ..This mechanism may explain, in part, beneficial vascular and metabolic health effects of green tea consumption...
  74. pmc Catechin treatment improves cerebrovascular flow-mediated dilation and learning abilities in atherosclerotic mice
    Annick Drouin
    Department of Surgery, Montreal Heart Institute Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 300:H1032-43. 2011
    ..We hypothesized that a chronic treatment with the polyphenol catechin would prevent endothelial dysfunction, maintain CBF responses, and protect learning abilities in atherosclerotic (..
  75. pmc Purification and characterization of a novel galloyltransferase involved in catechin galloylation in the tea plant (Camellia sinensis)
    Yajun Liu
    School of Life Science, Ministry of Education in China, Anhui Agricultural University, 130 West Changjiang Rd, Hefei, Anhui 230036, China
    J Biol Chem 287:44406-17. 2012
    ..ECGT had an optimum temperature of 30 °C and maximal reaction rates between pH 4.0 and 6.0. The enzyme reaction was inhibited dramatically by phenylmethylsulfonyl fluoride, HgCl(2), and sodium deoxycholate...
  76. pmc Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats
    Rajesh Aneja
    Department of Pediatrics, Division of Critical Care Medicine OSB5, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mol Med 10:55-62. 2004
    Epigallocatechin-3-gallate (EGCG) is the most prominent catechin in green tea. EGCG has been shown to modulate numerous molecular targets in the setting of inflammation and cancer...
  77. pmc Effects of green tea polyphenol (-)-epigallocatechin-3-gallate on newly developed high-fat/Western-style diet-induced obesity and metabolic syndrome in mice
    Yu Kuo Chen
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States
    J Agric Food Chem 59:11862-71. 2011
    ..The beneficial effects of EGCG are associated with decreased lipid absorption and reduced levels of inflammatory cytokines...
  78. ncbi (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry
    Noémie Calland
    Institut Pasteur de Lille, Center for Infection and Immunity of Lille CIIL, Lille, France
    Hepatology 55:720-9. 2012
    ..Finally, by successive inoculation of naïve cells with supernatant of HCV-infected cells in the presence of EGCG, we observed that EGCG leads to undetectable levels of infection after four passages...
  79. ncbi Influence of short-term consumption of the caffeine-free, epigallocatechin-3-gallate supplement, Teavigo, on resting metabolism and the thermic effect of feeding
    Mark C Lonac
    Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, USA
    Obesity (Silver Spring) 19:298-304. 2011
    ..Epigallocatechin-3-gallate (EGCG: the most bioactive catechin in green tea) inhibits catechol-O-methyltransferase, an enzyme contributing to the degradation of catecholamines...
  80. ncbi How can (-)-epigallocatechin gallate from green tea prevent HIV-1 infection? Mechanistic insights from computational modeling and the implication for rational design of anti-HIV-1 entry inhibitors
    Adel Hamza
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536, USA
    J Phys Chem B 110:2910-7. 2006
    ..These results and insights provide a rational basis for future design of novel, more potent inhibitors to block gp120-CD4 binding...
  81. ncbi Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases
    Silvia Mandel
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology and Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa 31096, Israel
    Free Radic Biol Med 37:304-17. 2004
    ..Green tea catechin polyphenols, formerly thought to be simple radical scavengers, are now considered to invoke a spectrum of ..
  82. pmc Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172)
    H Y Ahn
    Department of Pharmacology, College of Medicine, Chungbuk National University, Cheongju 361 763, South Korea
    Mol Biol Cell 10:1093-104. 1999
    ..The present findings may partly explain the anti-cancer and anti-atherosclerotic activity of green tea...
  83. ncbi Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41
    Shuwen Liu
    Lindsley F Kimball Research Institute, The New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    Biochim Biophys Acta 1723:270-81. 2005
    Theaflavin derivatives and catechin derivatives are the major polyphenols in black tea and green tea, respectively...
  84. pmc Nanochemoprevention by bioactive food components: a perspective
    Imtiaz A Siddiqui
    Department of Dermatology, University of Wisconsin, Medical Sciences Center B 25, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Pharm Res 27:1054-60. 2010
    ....
  85. ncbi Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue
    M Suganuma
    Saitama Cancer Center Research Institute, Japan
    Carcinogenesis 19:1771-6. 1998
    ....
  86. ncbi The behavior of vascular smooth muscle cells and platelets onto epigallocatechin gallate-releasing poly(l-lactide-co-epsilon-caprolactone) as stent-coating materials
    Han Hee Cho
    Department of Medical Simulation Engineering, Research Center for Nano Medical Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 29:884-93. 2008
    ..These results suggest that EGCG-releasing polymers can be effectively applied for fabricating an EGCG-eluting vascular stent to prevent in-stent restenosis and thrombosis...
  87. pmc Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes
    Arabinda Das
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29209, USA
    Cancer 116:164-76. 2010
    ....
  88. ncbi Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity
    Nelson Ferreira
    Grupo de Neurobiologia Molecular, Instituto de Biologia Molecular e Celular, 4150 180 Porto, Portugal
    FEBS Lett 583:3569-76. 2009
    ..In this study we tested (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of green tea, as an inhibitor of TTR amyloid formation...
  89. ncbi Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products
    Qian Cai
    Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi Lu Hospital of Shandong University, China
    Biosci Biotechnol Biochem 75:1692-7. 2011
    ..GSPB2 may therefore have therapeutic potential in preventing and treating vascular complications of diabetes mellitus...
  90. pmc (-)-Epigallocatechin-3-gallate increases the expression of genes related to fat oxidation in the skeletal muscle of high fat-fed mice
    Sudathip Sae-Tan
    Department of Food Science, The Pennsylvania State University, 332 Food Science Building, University Park, PA 16802, USA
    Food Funct 2:111-6. 2011
    ..In summary, it appears that EGCG modulates body weight gain in high fat-fed mice both by increasing the expression of genes related fat oxidation in the skeletal muscle and by modulating fat absorption from the diet...
  91. pmc Pharmacokinetic and chemoprevention studies on tea in humans
    H H Sherry Chow
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, United States
    Pharmacol Res 64:105-12. 2011
    ..Tea catechins and tea catechin metabolites/catabolites are bioavailable in the systemic circulation after oral intake of green tea or green tea ..
  92. ncbi Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress
    S K Katiyar
    Department of Dermatology, Volker Hall 501, 1530 3rd Ave S, The University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Carcinogenesis 22:287-94. 2001
    ..Further studies are warranted to study the preventive effects of EGCG against multiple exposures to UV light of human skin...
  93. ncbi Effects of quercetin and catechin on hepatic glutathione-S transferase (GST), NAD(P)H quinone oxidoreductase 1 (NQO1), and antioxidant enzyme activity levels in rats
    Heike Wiegand
    Christian Albrechts University, Kiel, Germany
    Nutr Cancer 61:717-22. 2009
    Cell culture data indicate that quercetin and catechin may affect the activity of phase II and antioxidant enzymes. However, little is known about the impact of dietary flavonoids in vivo...
  94. ncbi Epigallocatechin gallate modulates cytokine production by bone marrow-derived dendritic cells stimulated with lipopolysaccharide or muramyldipeptide, or infected with Legionella pneumophila
    James Rogers
    Department of Medical Microbiology and Immunology, University of South Florida, Tampa, FL 33612, USA
    Exp Biol Med (Maywood) 230:645-51. 2005
    The primary polyphenol in green tea extract is the catechin epigallocatechin gallate (EGCG). Various studies have shown significant suppressive effects of catechin on mammalian cells, either tumor or normal cells, including lymphoid cells...
  95. pmc Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: "in vivo" evidence from FAP mice models
    Nelson Ferreira
    Grupo de Neurobiologia Molecular, IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
    PLoS ONE 7:e29933. 2012
    ..We have recently reported that epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, is able to inhibit TTR aggregation and fibril formation, "in vitro" and in a cellular system, and ..
  96. ncbi Molecular basis for cancer chemoprevention by green tea polyphenol EGCG
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, Japan
    Forum Nutr 61:156-69. 2009
    ..Our data shed new light on the molecular basis for the cancer-preventive activity of EGCG in vivo and helps in the design of new strategies to prevent cancer...
  97. ncbi Neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) on paraquat-induced apoptosis in PC12 cells
    Rong Rong Hou
    Laboratory of Integrated Traditional Chinese Medicine and Western Medicine on Elderly Encephalopathy, Research Center of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, 710032 Xi an, Shaanxi, China
    Cell Biol Int 32:22-30. 2008
    ..The present study supports the notion that EGCG could be used as a neuroprotective agent for treatment of neurodegenerative diseases...
  98. ncbi Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase
    Yvonne Steffen
    Institute for Biochemistry and Molecular Biology I, Heinrich Heine University Duesseldorf, D 4000 Duesseldorf, Germany
    Arch Biochem Biophys 469:209-19. 2008
    ..Notably, HUVEC converted (-)-epicatechin to NADPH oxidase-inhibitory methyl ethers. These data identify endothelial NADPH oxidase as candidate target of dietary flavonoids and particularly of their metabolites...
  99. pmc Chemopreventive potential of natural compounds in head and neck cancer
    Mohammad Aminur Rahman
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    Nutr Cancer 62:973-87. 2010
    ..This review describes recent advances in the understanding of the complex signaling networks driving cancer progression and of molecularly targeted natural compounds under preclinical and clinical investigation...
  100. pmc Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]
    Rashmi Singh
    Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi, India
    Life Sci 86:907-18. 2010
    ....
  101. ncbi Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction
    Wai Mun Loke
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Arterioscler Thromb Vasc Biol 30:749-57. 2010
    ..different polyphenolic classes, namely quercetin (flavonol), (-)-epicatechin (flavan-3-ol), theaflavin (dimeric catechin), sesamin (lignan), or chlorogenic acid (phenolic acid), reduce atherosclerotic lesion formation in the ..

Research Grants64

  1. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..The epidemiological data are inconsistent, however, likely due to genetic differences in catechin metabolism...
  2. Combined use of green tea and quercetin in prostate cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2012
    ..This novel treatment will retain the non-toxic character of green tea and at the same time increase its activity in chemoprevention of CaP. ..
  3. Phase I Study to Evaluate Safety and Toxicity of EGCG in HIV-1-Infected Subjects
    Christina L Nance; Fiscal Year: 2011
    ..One such CAM candidate is the green tea catechin, epigallocatechin gallate (EGCG)...
  4. Effects of Cocoa Flavonols on Myocardial Infarction Size and Post-Injury Injury
    Francisco Villarreal; Fiscal Year: 2009
    ..Cocoa powder is more than 10% flavanols (catechin and epicatechin) by weight...
  5. Regulation of Intestinal Bile Acid Transport
    Waddah A Alrefai; Fiscal Year: 2013
    ..Also beneficial dietary components such as green tea catechin, (-)-epigallocatechin-3-gallate, EGCG, inhibits ASBT function in a lipid-raft dependent manner...
  6. Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin
    Francisco J Villarreal; Fiscal Year: 2013
    ..abstract_text> ..
  7. Mechanisms of Reduced Heart Failure Pathogenesis with Phytochemical Intake
    Steven F Bolling; Fiscal Year: 2012
    ..Grape phytochemicals of broad interest include anthocyanins, flavanols (catechin, epicatechin, quercetin), and stilbenes (resveratrol)...
  8. Neuroprotective effect of flavanol (-) epicatechin after intracerebral hemorrhage
    Jian Wang; Fiscal Year: 2013
    ..Ultimately, the data may help the general public and healthcare providers make informed decisions on whether (-)-epicatechin could be accepted as an adjunct treatment in patients with ICH. ..
  9. EGCG Has Anti-prostate Cancer Activity by Inhibiting hsp90
    Thomas A Gasiewicz; Fiscal Year: 2012
    ..Epigallocatechin-3-gallate (EGCG), the major catechin in green tea has been shown to be a primary component eliciting this biological activity...
  10. FREE RADICAL LIPID PEROXIDATION DAMAGE
    ALOYS TAPPEL; Fiscal Year: 1991
    ..capacity has not been adequately determined, including beta-carotene, uric acid, coenzyme Q10, and (+)-catechin. 5...
  11. Targeting cellular bioenergetics for the prevention and treatment of diabetes
    Francisco J Villarreal; Fiscal Year: 2011
    ....
  12. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..adequate diet, or a high fat-micronutrient marginal diet, supplemented or not with the flavonoids, quercetin and catechin. They will use biochemical markers and immunohistochemistry to evaluate antioxidant capacity and redox status in ..
  13. Drug Interactions and Bioavailability of Cranberry
    Jennifer Donovan; Fiscal Year: 2005
    ..These data will also complement NCCAM studies assessing the clinical safety and efficacy of CB and will allow more informed recommendations about the use of CB when combined with conventional medications. ..
  14. CARBON-13 MAGNETIC RESONANCE - METHODS AND THEORY
    DAVID MORRIS GRANT; Fiscal Year: 2010
    ..Thus, we intend to study a number of important bio-systems: flavenoids such as catechin (Z =2), Taxol. (Z =2x1/2)...
  15. POTENTIAL FETOPROTECTANTS FROM ETOH-INDUCED STRESS
    Linda La Grange; Fiscal Year: 2000
    ..now want to test the antioxidant effects of SY and four other antioxidant flavonoids; quercetin, myricetin, (+)-catechin, and apigenin on EtOH-exposed fetal rat brain and liver tissue...
  16. Mechansim of tea catechin's inhibition of angiogenesis
    Mohsen Meydani; Fiscal Year: 2003
    ..abstract_text> ..
  17. ENDOTHELIAL CELL FIBRINOLYSIS INDUCED BY WINE PHENOLICS
    MICHAEL AIKENS; Fiscal Year: 2001
    ..It is conceivable that selected wine phenolic compounds, resveratrol, quercetin and catechin may have additional properties which may affect EC function in the long-term, in particular fibrinolysis, ..
  18. Anti-cancer effects by the green tea catechins
    SEUNG BAEK; Fiscal Year: 2006
    ..our hypothesis of this novel proposal is that the cancer chemopreventive effect of green tea components including catechin (-) epigallocatechin 3-gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC), and epicatechin (EC) is ..
  19. Evaluation of the Effect of Green Tea Polyphenols on IBD
    GERALD DRYDEN; Fiscal Year: 2009
    ..Specific aim 3 will further evaluate the safety of GrTP in subjects with IBD, while providing preliminary data on the efficacy of this therapy in patients with active ulcerative colitis. ..
  20. NEW ASYMMETRIC PROCESSES FOR USE IN ORGANIC SYNTHESIS
    K Sharpless; Fiscal Year: 1999
    ..Encouraged by the successful asymmetric dihydroxylation of isolated olefins, a continuing long-range goal of this project is asymmetric epoxidation of isolated olefins. ..
  21. Preclinical Evaluation of Black Tea Extracts
    David Evans; Fiscal Year: 2002
    ..1. Prepare standardized, modified theaflavin extracts from decaffeinated green tea 2. Prepare from catechin precursors the following pure compounds: theatlavin(TF-1), theaflavin-3-monogallate and theaflavin-3'-monogallate ..
  22. PREVENTION OF CARTILAGE DEGRADATION BY GREEN TEA
    TARIQ HAQQI; Fiscal Year: 2006
    ..Data from our preliminary studies showed that when the green tea catechin epigallocatechin-3-gallate (EGCG) was added to human chondrocyte cultures (1) inhibited IL-1 -induced cartilage ..
  23. Phytonutrient Suppression of Wnt Signalling in Cancer
    Amy Yee; Fiscal Year: 2009
    ..The focus of this application is an investigation of the green tea phytonutrient EGCG [(-) epigallo-catechin gallate] in suppressing proliferation and invasiveness in early breast cancer...
  24. Identification of Green Tea Polyphenol-Targeted Genes
    Stephen Hsu; Fiscal Year: 2004
    ..Data generated from this proposal may reveal novel drug targets for treatment of head and neck cancer. ..
  25. Reactivation Methylation-Silenced Genes by Polyphenols
    Chung Yang; Fiscal Year: 2007
    ..5. To determine whether EGCG, alone or in combination with other agents, can prevent hypermethylation of genes and tumor development in the intestinal tumorigenesis model in the Min mice. ..
  26. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2007
    ..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
  27. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Chung Yang; Fiscal Year: 2005
    ..Jointly, we intend to make major contributions to the use of tea for the I chemoprevention of cancer. ..
  28. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2005
    ..The applicant and colleagues will address key issues concerning the bioavailability and bioactivities of O-methyl, glucuronide, and sulfate derivatives and two ring-fission metabolites of tea catechins. ..
  29. Prevention of UV-carcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2004
    ..abstract_text> ..
  30. Proanthocyanidins: Novel Skin Cancer Preventive Agent
    Santosh Katiyar; Fiscal Year: 2006
    ..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
  31. Bioavailability of Tea Polyphenols in Prostate Cancer
    Susanne Henning; Fiscal Year: 2002
    ..showed that due to the different content of tea leaves in the bag, some black tea preparations have similar catechin content compared to green tea preparations...
  32. Prevention of Photocarcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2003
    ..abstract_text> ..
  33. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2011
    ..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..
  34. Prevention of skin cancer by green tea polyphenols
    Santosh Katiyar; Fiscal Year: 2009
    ..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
  35. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2010
    ..abstract_text> ..
  36. The Proteasome as Molecular Target of Grape Polyphenols
    QING PING DOU; Fiscal Year: 2005
    ..abstract_text> ..
  37. TEA TARGETING PROTEASOME--A ROLE IN CANCER PREVENTION
    QING DOU; Fiscal Year: 2002
    ..A Future Aim is to determine whether in vivo proteasome-inhibitory ability of tea polyphenols is related to their antitumor activity using nude mice bearing human prostate tumors. ..
  38. Acylation as an Approach to Enhance the Cancer Preventive Effect of EGCG
    Shengmin Sang; Fiscal Year: 2007
    ..2. To determine the bioavailability and efficacy of acylated EGCG in the prevention of ACF formation in the AOM-treated mouse model. ..
  39. Computer Directed Photodynamic Therapy of Prostate Ca
    Jerzy Jankun; Fiscal Year: 2005
    ....
  40. PURINERGIC AXIS OF CARDIAC BLOOD VESSELS
    IAIN BUXTON; Fiscal Year: 2001
    ..We will approach these aims with biochemical, pharmacological, molecular, cell biological and microscopic methods employing intact blood vessels, cells in primary culture and subcellular fractions. ..
  41. Neuroprotective Role of Fetuin in Cerebral Ischemia
    Haichao Wang; Fiscal Year: 2008
    ..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..
  42. Effect of digestion on the cancer chemopreventative activity of tea catechins
    Mario Ferruzzi; Fiscal Year: 2007
    ..However, stability of tea catechins to digestive conditions is known to be poor, suggesting that catechin digestive products may actually be responsible, in part, for the chemopreventative activity of this beverage...
  43. Epigallocatechin gallate, Prostate cancer & Angiogenesis
    Myoung Kim; Fiscal Year: 2004
    ..abstract_text> ..
  44. Transcription Regulation and Biological Function of NAG1
    SEUNG BAEK; Fiscal Year: 2005
    ..Cancer and inflammation are certainly environmentally relevant problems and thus this project will provide new clues to aid in the understanding of how these drugs alter tumor development. ..
  45. MODULATION BY TEA OF EARLY EFFECTS OF UV ON SKIN
    Allan Conney; Fiscal Year: 2003
    ..abstract_text> ..
  46. Modulation of Oxidative Damage by Tea Polyphenols
    Jia Sheng Wang; Fiscal Year: 2002
    ..The results of this proposed study will help to understand the mechanisms of antioxidative role of tea polyphenols in modulating human hepatocarcinogenesis caused by hepatitis B/C viruses and aflatoxins. ..
  47. Selective Induction of Estrogen Conjugative Metabolism
    Bao Ting Zhu; Fiscal Year: 2006
    ..These studies will also provide examinations of the important roles of bioactive estrogen metabolites (e.g., 4-OH-E2 and 16alpha-OH-E2) in estrogen-induced cancers. ..
  48. Integrated Instrumentation for Proteomics
    Helen Kim; Fiscal Year: 2002
    ....
  49. CYCLOOXYGENASE AND ANTI-INFLAMMATORY DRUGS IN AD
    Giulio Pasinetti; Fiscal Year: 2001
    ..The outcome of the proposed studies will be immediately relevant to the design of human trials. ..
  50. SIGNAL TRANSDUCTION THOUGH THE C-CBL PROTOONCOGENE
    Kristiina Vuori; Fiscal Year: 2001
    ..In each case, the effects on various biochemical and biological signaling events will be studied. ..
  51. Calcium, Dairy, and Body Fat in Adolescents
    Connie Weaver; Fiscal Year: 2006
    ..This study will evaluate calcium/dairy as a modulator of energy balance, important to the management of body fat in children. ..
  52. Towards a Vaccine for the Common Cold
    THOMAS JAMES SMITH; Fiscal Year: 2010
    ..If successful, the methods developed here will also yield a rapid way to identify potential, conserved, vaccine targets for other antigenically diverse viruses as well. ..
  53. Epigenetics of Dietary EGCG in Cancer Prevention
    Trygve Tollefsbol; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  54. Pinitol a Natural Extract from Pine Cones and Alzheimer's Disease
    Giulio Pasinetti; Fiscal Year: 2006
    ..abstract_text> ..
  55. Mechanism of anti-phagocytosis by Yersinia pestis
    Kristiina Vuori; Fiscal Year: 2005
    ..We further expect that the inhibitors to be identified will be a valuable starting point for the further development of novel drugs that can be used to combat plague mortality. ..
  56. Chemoprevention of Head and Neck Cancer with ZD1839 and Celecoxib
    Dong Shin; Fiscal Year: 2008
    ..Biomarker changes will be correlated with cancer incidence by statistical analyses. We will also determine whether such biomarker changes can serve as intermediate endpoint(s) in this chemopreventive trial. ..
  57. Mechanisms of chemopreventive effect of resveratrol
    Zigang Dong; Fiscal Year: 2009
    ..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
  58. THE UCLA CLINICAL NUTRITION RESEARCH UNIT
    David Heber; Fiscal Year: 2006
    ..The UCLA CNRU is serving as a regional and national resource at the cutting edge of nutrition and cancer prevention research...
  59. Cell Cycle and COX-2 in a Mouse Model of Alzheimer's
    Giulio Pasinetti; Fiscal Year: 2004
    ....
  60. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  61. Effects of TPA on Leukemia and Solid Tumors
    Allan Conney; Fiscal Year: 2006
    ..Blood levels of TPA that are associated with inhibition of tumor growth will be determined. The effect of inhibitors of tumor growth on proliferation and apoptosis in the tumors will be determined. ..
  62. Validation of Web-based Multimedia Dietary Assessment Tools
    Lenore Arab; Fiscal Year: 2010
    ..Theepidemiology. The study will als contribute to our confidence in these dietary and activity assessment instruments in multiracial populations. ..
  63. Dietary Polyphenols Are Consequential Epigenetic Modulators of Gene Expression
    BAOTING ZHU; Fiscal Year: 2009
    ..It is expected that the outcomes of the proposed studies will have direct clinical utility in the near future and far-reaching human health implications. ..