chromans

Summary

Summary: Benzopyrans saturated in the 2 and 3 positions.

Top Publications

  1. ncbi First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway
    Kanjoormana A Manu
    Department of Pharmacology, Yong Loo Lin School of Medicine, Cancer Science Institute of Singapore, National University of Singapore
    Clin Cancer Res 18:2220-9. 2012
  2. pmc gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
    Oxid Med Cell Longev 3:35-43. 2010
  3. ncbi Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants
    Karim S Echtay
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    J Biol Chem 277:47129-35. 2002
  4. ncbi In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metabolite
    Alejandro Betancor-Fernandez
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Germany
    Free Radic Res 36:915-21. 2002
  5. pmc Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide
    Qing Jiang
    Department of Foods and Nutrition, Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN 47907, USA
    Int J Cancer 130:685-93. 2012
  6. ncbi Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes
    Daniel C Kemp
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 83:207-14. 2005
  7. pmc Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts
    Suzana Makpol
    Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Biochemistry, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 67:135-43. 2012
  8. ncbi Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil
    S Ikeda
    Department of Food and Nutrition, School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
    J Nutr 131:2892-7. 2001
  9. ncbi The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes
    Priscilla L K Lim
    Department of Pharmacology, Yong Loo Lin School of Medicine National University of Singapore, Singapore 117595
    Toxicol Sci 101:341-9. 2008
  10. ncbi Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis
    Kwang Seok Ahn
    Cytokine Research Section, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:809-20. 2007

Research Grants

Detail Information

Publications248 found, 100 shown here

  1. ncbi First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway
    Kanjoormana A Manu
    Department of Pharmacology, Yong Loo Lin School of Medicine, Cancer Science Institute of Singapore, National University of Singapore
    Clin Cancer Res 18:2220-9. 2012
    ..Hence, novel agents that are safe and effective are urgently needed. Whether γ-tocotrienol can sensitize gastric cancer to capecitabine in vitro and in a xenograft mouse model was investigated...
  2. pmc gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals
    Suzana Makpol
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
    Oxid Med Cell Longev 3:35-43. 2010
    ..Thus, these data suggest that gamma-tocotrienol protects against oxidative stress-induced cellular ageing by modulating the telomere length possibly via telomerase...
  3. ncbi Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants
    Karim S Echtay
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    J Biol Chem 277:47129-35. 2002
    ..We conclude that superoxide (or its products) exerts its uncoupling effect by activating the proton transport mechanism of uncoupling proteins at the matrix side of the mitochondrial inner membrane...
  4. ncbi In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metabolite
    Alejandro Betancor-Fernandez
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Germany
    Free Radic Res 36:915-21. 2002
    ..We conclude that alpha-CEHC is a molecule with good antioxidant activity, having the advantage over Trolox of being a naturally occurring compound. These properties might be useful for research or industrial purposes...
  5. pmc Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide
    Qing Jiang
    Department of Foods and Nutrition, Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN 47907, USA
    Int J Cancer 130:685-93. 2012
    ..07) by γT, in nude mice. These findings provide a molecular basis of γTE-stimulated cancer cell death and support the notion that elevation of intracellular dihydroceramide and dihydrosphingosine is likely a novel anticancer mechanism...
  6. ncbi Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes
    Daniel C Kemp
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 83:207-14. 2005
    ..In conclusion, xenobiotics may alter hepatic bile acid transport by inhibiting both hepatic uptake and biliary excretion...
  7. pmc Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts
    Suzana Makpol
    Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Biochemistry, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Clinics (Sao Paulo) 67:135-43. 2012
    ..This study determined the molecular mechanism of γ-tocotrienol, a vitamin E homolog, in the prevention of cellular aging in human diploid fibroblasts using the expression of senescence-associated genes...
  8. ncbi Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil
    S Ikeda
    Department of Food and Nutrition, School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
    J Nutr 131:2892-7. 2001
    ..05) in many tissues by feeding sesame seeds. These data suggest that the transport and tissue uptake of vitamin E isoforms are different. Dietary sesame seeds elevate the concentrations of both tocopherols and tocotrienols...
  9. ncbi The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes
    Priscilla L K Lim
    Department of Pharmacology, Yong Loo Lin School of Medicine National University of Singapore, Singapore 117595
    Toxicol Sci 101:341-9. 2008
    ..Furthermore, the data support our concept that targeted delivery of an antioxidant to mitochondria can inhibit upstream signaling and protect from troglitazone-induced lethal cell injury...
  10. ncbi Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis
    Kwang Seok Ahn
    Cytokine Research Section, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:809-20. 2007
    ..Overall, our results demonstrate that gamma-tocotrienol inhibited the NF-kappaB activation pathway, leading to down-regulation of various gene products and potentiation of apoptosis...
  11. ncbi Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells
    Ha Il Kim
    Department of Biochemistry and Molecular Biology, the Institute of Genetic Science, Yonsei University College of Medicine, Seoul, Korea
    Diabetes 51:676-85. 2002
    ....
  12. ncbi Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid)
    Ilhami Gulcin
    Faculty of Arts and Sciences, Department of Chemistry, Ataturk University, TR 25240 Erzurum, Turkey
    Toxicology 217:213-20. 2006
    ..In addition, caffeic acid is an effective ABTS(+) scavenging, DPPH scavenging, superoxide anion radical scavenging, total reducing power and metal chelating on ferrous ions activities...
  13. ncbi Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
    A M Lefebvre
    LBRE, U 325 INSERM, Departement d Atherosclerose, Institut Pasteur, Lille, France
    Nat Med 4:1053-7. 1998
    ..Our data indicate that PPARgamma activation modifies the development of colon tumors in C57BL/61-APCMin/+ mice...
  14. ncbi Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt
    C Funk
    F Hoffmann La Roche Ltd, Non Clinical Development Drug Safety, PRNS 69 152, 4070 Basel, Switzerland
    Toxicology 167:83-98. 2001
    ..Such an interaction might lead potentially also in man to a troglitazone-induced intrahepatic cholestasis, potentially contributing to the formation of troglitazone-induced liver injuries...
  15. ncbi Effects of conjugated linoleic acid and troglitazone on lipid accumulation and composition in lean and Zucker diabetic fatty (fa/fa) rats
    Angela A Wendel
    Department of Human Nutrition, The Ohio State University, Columbus, Ohio 43210, USA
    Lipids 41:241-7. 2006
    ..The effects of CLA and TZD on hepatic lipid composition suggest that the effects of these two agents on glucose tolerance may be associated with a reduction in SCD-1...
  16. ncbi Troglitazone-induced liver failure: a case study
    David J Graham
    Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, HFD 400, Room 15B 32, Rockville, MD 20857, USA
    Am J Med 114:299-306. 2003
    ..We evaluated the clinical features of all cases reported to the Food and Drug Administration and estimated the duration and magnitude of the risk of liver failure associated with continued use of the drug...
  17. pmc γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
    Peramaiyan Rajendran
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Cancer Science Institute of Singapore, National University of Singapore, Singapore
    Br J Pharmacol 163:283-98. 2011
    ..In the present study, we investigated whether the apoptotic, antiproliferative and chemosensitizing effects of γ-tocotrienol are associated with its ability to suppress STAT3 activation in hepatocellular carcinoma (HCC)...
  18. pmc Alpha-tocopherol beta-oxidation localized to rat liver mitochondria
    Debbie J Mustacich
    Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 48:73-81. 2010
    ..An unexpected finding was that alpha-CEHC, the end product of alpha-tocopherol metabolism, was found almost exclusively in mitochondria. These data are the first to indicate a mitochondrial role in alpha-tocopherol metabolism...
  19. ncbi γ-Tocotrienol inhibits angiogenesis of human umbilical vein endothelial cell induced by cancer cell
    Yang Li
    Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150081, People s Republic of China
    J Nutr Biochem 22:1127-36. 2011
    ..Thus, our results suggest that γ-tocotrienol has a potential chemopreventive agent via antiangiogenesis...
  20. pmc Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells
    Dorrelyn Patacsil
    Cancer Research Laboratory, Department of Biological and Environmental Sciences, University of the District of Columbia, Washington, DC 20008, USA
    J Nutr Biochem 23:93-100. 2012
    ..In summary, we demonstrate that γ-T3 modulates ER stress signaling and have identified ATF3 as a molecular target for γ-T3 in breast cancer cells...
  21. ncbi Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells
    Paul Aoun
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Invest Ophthalmol Vis Sci 44:2999-3004. 2003
    ..Glaucoma and other retinal disorders are some of the major complications in diabetes. In the present study, the role that PPAR-gamma ligands play in protecting retinal ganglion cells (RGC-5) against glutamate insult was explored...
  22. ncbi Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells
    Hui Kun Liu
    Department of Nutrition and Food Hygiene, Public Health School, Harbin Medical University, Nangang District, Harbin, Heilongjiang Province 150086, People s Republic of China
    J Nutr Biochem 21:206-13. 2010
    ..01). These findings suggest a potential mechanism of gamma-tocotrienol-mediated antitumor metastasis activity and indicate the role of vitamin E as potential chemopreventative agents against gastric cancer...
  23. ncbi Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities
    Michie M K Ong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117 597
    Toxicol Sci 97:205-13. 2007
    ..These data are consistent with our hypothesis that inherited or acquired mitochondrial abnormalities may be one of the contributing determinants of susceptibility to troglitazone-induced idiosyncratic liver injury...
  24. ncbi gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells
    Wenguang Sun
    Department of Clinic Nutrition, The First Clinical College of Harbin Medical University, Nangang District, Harbin 150001, P R China
    J Nutr Biochem 20:276-84. 2009
    ..Thus, our findings revealed gamma-tocotrienol as a potential, new chemopreventive agent for human gastric cancer...
  25. pmc Human alveolar epithelial cell injury induced by cigarette smoke
    Beata Kosmider
    Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 6:e26059. 2011
    ..CS induces oxidative stress and cell death, and this cell toxicity plays a key role in the pathogenesis of several pulmonary diseases...
  26. ncbi Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists
    Rikio Yoshimura
    Department of Urology, Osaka City University Medical School, Osaka, Japan
    Int J Cancer 104:597-602. 2003
    ..PPAR-gamma is expressed in bladder tumor, and results suggest that PPAR-gamma ligands may mediate potent antiproliferative effects against BT cells. Thus, PPAR-gamma has the ability to become a new target in treatment of bladder tumor...
  27. pmc {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment
    Ajaikumar B Kunnumakkara
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 70:8695-705. 2010
    ..Overall, our findings suggest that γ-T3 can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing NF-κB-mediated inflammatory pathways linked to tumorigenesis...
  28. ncbi Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity
    Sumit J Shah
    School of Pharmacy, 700 University Avenue, University of Louisiana at Monroe, Monroe, LA 71209 0470, USA
    Exp Biol Med (Maywood) 230:235-41. 2005
    ..In summary, these findings demonstrate that the antiproliferative effects of gamma-tocotrienol result, at least in part, from a reduction in Akt and NFkappaB activity in neoplastic +SA mammary epithelial cells...
  29. ncbi Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme
    Claire L Varley
    Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York YO10 5YW, UK
    J Cell Sci 117:2029-36. 2004
    ....
  30. ncbi Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice
    Emi Osawa
    The Third Department of Internal Medicine, Yokohama City University School of Medicine, Japan
    Gastroenterology 124:361-7. 2003
    ..In the present study, 3 different kinds of PPARgamma ligands were subjected to the experiments to confirm their suppressive effects on colon carcinogenesis...
  31. ncbi gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line
    Sheng Bi
    Central Laboratory, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, People s Republic of China
    Toxicology 274:27-33. 2010
    ..These data suggest that HIF-1alpha/VEGF could be a promising target for gamma-tocotrienol in an effective method of chemoprevention and chemotherapy in human gastric cancer...
  32. ncbi Mechanisms of troglitazone hepatotoxicity
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, California 94720 7360, USA
    Chem Res Toxicol 16:679-87. 2003
  33. ncbi Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat
    C Funk
    F. Hoffmann-La Roche Ltd, Pharmaceuticals Division, Non-Clinical Development-Drug Safety, Basel, Switzerland
    Mol Pharmacol 59:627-35. 2001
    ..Such an interaction might lead to a troglitazone-induced intrahepatic cholestasis in humans as well, contributing to the formation of a troglitazone-induced liver toxicity...
  34. ncbi Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis
    Joana Gil
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra and Center for Neuroscience and Cell Biology of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 35:1500-14. 2003
    ..Thus, endogenous ROS generation and the rise in intracellular calcium are important inter-players in STS-triggered apoptosis. Furthermore, the antioxidants may help to prolong retinal cell survival upon apoptotic cell death...
  35. pmc Effect of experimental treatment on GAPDH mRNA expression as a housekeeping gene in human diploid fibroblasts
    Azalina Zainuddin
    Department of Biochemistry, Faculty of Medicine, National University of Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    BMC Mol Biol 11:59. 2010
    ..Standard curve of GAPDH expression in serial diluted total RNA, melting curve analysis and agarose gel electrophoresis were used to determine the reliability of GAPDH as reference gene...
  36. ncbi Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms
    Jui Pandhare
    Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, NCI Frederick, National Institutes of Health, Frederick, MD 21702, USA
    J Biol Chem 281:2044-52. 2006
    ..Our results suggest that the induction of apoptosis by troglitazone may, at least in part, be mediated by targeting POX gene expression for generation of ROS by POX both by PPARgamma-dependent and -independent mechanisms...
  37. ncbi Effect of thiazolidinediones on bile acid transport in rat liver
    Kris L Snow
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48105, USA
    Life Sci 80:732-40. 2007
    ..If hepatotoxicity is associated with this effect, then hepatotoxicity is not limited to troglitazone. Alternatively, if hepatotoxicity is limited to troglitazone, other mechanisms are responsible for its reported hepatotoxicity...
  38. ncbi Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors
    Ramaswamy Kannappan
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 9:2196-207. 2010
    ..Overall, our results show that gamma-T3 sensitizes tumor cells to TRAIL by upregulating DRs through the ROS/ERK/p53 pathway and by downregulating cell survival proteins...
  39. ncbi Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells
    S T de Dios
    Cell Biology of Diabetes Laboratory, Baker Medical Research Institute, P.O. Box 6492, Victoria, Melbourne 8008, Australia
    J Diabetes Complications 15:120-7. 2001
    ..The effects of troglitazone and rosiglitazone on endothelial cell proliferation and NHE activity, although contrasting, are consistent with a central signalling role of this transporter in cell proliferation...
  40. ncbi HER2 regulation of peroxisome proliferator-activated receptor gamma (PPARgamma) expression and sensitivity of breast cancer cells to PPARgamma ligand therapy
    Zhibo Yang
    Department of Molecular, Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:3198-203. 2003
    ..In summary, these findings show for the first time that HER2 up-regulates PPARgamma expression and modulates the sensitivity of breast cancer cells to PPARgamma ligand therapy...
  41. ncbi Activators of the nuclear receptor PPARgamma enhance colon polyp formation
    E Saez
    The Salk Institute for Biological Studies, Howard Hughes Medical Institute, La Jolla, California 92037, USA
    Nat Med 4:1058-61. 1998
    ....
  42. ncbi Deleterious effects of nicotine on the ultrastructure of oocytes: role of gamma-tocotrienol
    Mohd Hamim Rajikin
    Faculty of Medicine, Universiti Technologi MARA, Shah Alam, Selangor, Malaysia
    Med Sci Monit 15:BR378-83. 2009
    ..The present study investigated the effect of daily supplementation of gamma-tocotrienol on oocytes of nicotine-treated mice...
  43. ncbi Mitigation of NADH: ubiquinone oxidoreductase deficiency by chronic Trolox treatment
    Werner J H Koopman
    Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Biochim Biophys Acta 1777:853-9. 2008
    ..However, such treatment may only be beneficial to patients with a relatively small reduction in intrinsic catalytic defect of the complex...
  44. ncbi Peroxisome proliferator-activated receptor-gamma agonists cause growth arrest and apoptosis in human ovarian carcinoma cell lines
    Y C Yang
    Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
    Int J Gynecol Cancer 17:418-25. 2007
    ..As a result, these agonists may serve as future drugs for the prevention and treatment of ovarian cancer...
  45. ncbi Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: the role of oxidative stress and D1 dopamine receptor
    Michael Y Aksenov
    Department of Psychology, Program in Behavioral Neuroscience, University of South Carolina, Columbia, SC 29208, USA
    Neurotoxicology 27:217-28. 2006
    ..Our results demonstrate that cocaine-mediated potentiation of Tat neurotoxicity may be related to its ability to augment Tat-induced oxidative stress...
  46. ncbi Troglitazone and liver injury: in search of answers
    Mario Chojkier
    Department of Medicine and Cancer Center, Veterans Affairs Healthcare System and University of California, San Diego, CA 92161, USA
    Hepatology 41:237-46. 2005
  47. ncbi Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors
    R Nergårdh
    Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Pharmacol Biochem Behav 82:495-505. 2005
    ..We suggest that the balance between signaling via dopamine D1 and D5 receptors determines the functional effects of agonists at D1/D5 receptors...
  48. ncbi Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips
    R d'Emmanuele di Villa Bianca
    Dipartimento di Farmacologia Sperimentale, Universita di Napoli Federico II, Naples, Italy
    Int J Impot Res 17:127-33. 2005
    ....
  49. ncbi Troglitazone improves blood flow by inhibiting neointimal formation after balloon injury in Otsuka Long-Evans Tokushima fatty rats
    Kyeong Min Min
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Metabolism 51:998-1002. 2002
    ..These data suggest that TGZ is a potent inhibitor of VSMC proliferation both in vivo and in vitro through a direct effect on VSMCs, and that TZDs might be very useful in the treatment and prevention of restenosis after balloon injury...
  50. ncbi gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells
    G V Samant
    College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209 0470, USA
    Cell Prolif 39:563-74. 2006
    ....
  51. ncbi Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity
    Richard L Kraus
    Department of Molecular Neuroscience, Merck Research Laboratories San Diego, California 92121, USA
    J Neurochem 94:819-27. 2005
    ..Our findings suggest that the direct antioxidant activity of minocycline may contribute to its neuroprotective effects in some cell-based assays and animal models of neuronal injury...
  52. ncbi Effects of troglitazone on HepG2 viability and mitochondrial function
    Mark A Tirmenstein
    Department of Safety Assessment and Department of Safety Assessment Statistics, GlaxoSmithKline, UE0360, 709 Swedeland Road, King of Prussia, Pennsylvania 19406 0939, USA
    Toxicol Sci 69:131-8. 2002
    ..These observations in HepG2 cells suggest that TRO disrupts mitochondrial function, leading to mitochondrial permeability transition and cell death...
  53. ncbi Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines
    Sandra Schaefer
    Department of Chemistry, Division of Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Kaiserslautern, Germany
    Mol Nutr Food Res 50:24-33. 2006
    ..In conclusion, apple juice extracts distinctly reduce oxidative cell damage in human colon cell lines, an effect, which in part can be accounted for by their major constituents...
  54. ncbi Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells
    Myung Ae Bae
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
    Mol Pharmacol 63:401-8. 2003
    ..These data strongly suggest that hepatotoxic TRO causes apoptosis by activating the JNK-dependent cell death pathway accompanied by increased Bid cleavage and elevation of proapoptotic proteins...
  55. ncbi Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling
    Wenguang Sun
    Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin 150086, People s Republic of China
    Br J Nutr 99:1247-54. 2008
    ..The results suggest that key regulators in tocotrienol-induced apoptosis may be Bcl-2 families and caspase-3 in SGC-7901 cells through down regulation of the Raf-ERK signalling pathway...
  56. ncbi Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury
    Yie Hou Lee
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Toxicol Appl Pharmacol 231:43-51. 2008
    ....
  57. ncbi Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells
    Wei Li Xu
    Department of Nutrition and Food Hygiene, Public Health School, Harbin Medical University, Harbin, People s Republic of China
    Nutrition 25:555-66. 2009
    ..To investigate the chemopreventive effects of gamma-tocotrienol on colon cancer, we examined its capacity to inhibit proliferation and induce apoptosis in HT-29 cells and explored the mechanism underlying these effects...
  58. ncbi Involvement of retinoic acid receptor-alpha-mediated signaling pathway in induction of CD38 cell-surface antigen
    K Mehta
    Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Blood 89:3607-14. 1997
    ..These results suggest that regulation of CD38 expression, both in vitro and in vivo, is under the direct control of RAR-alpha retinoid receptors...
  59. pmc Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells
    Huey Chuan Cheng
    Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan
    Mol Vis 14:95-104. 2008
    ..The mechanism of the TGZ effect was also investigated by studying major TGFbeta2-induced signaling including activation of Smad and p38 mitogen activated protein kinase (MAPK)...
  60. ncbi Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status
    S P Yap
    School of Pharmaceutical Sciences, University of Science Malaysia, Penang
    J Pharm Pharmacol 53:67-71. 2001
    ..The mean apparent volume of distribution (Vd/f) values under the fed state were significantly smaller than those of the fasted state, which could be attributed to increased absorption of the tocotrienols in the fed state...
  61. pmc Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death
    Y F Guan
    Division of Nephrology, Veterans Administration Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neoplasia 1:330-9. 1999
    ..Taken together, these results demonstrate that PPARgamma is expressed in human TCCa where it may play a role in regulating TCCa differentiation and survival, thereby providing a potential target for therapy of uroepithelial cancers...
  62. ncbi Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin E
    Dragan Radosavac
    Institute of Physiological Chemistry I, Heinrich Heine University, P O Box 101007, 40001 Dusseldorf, Germany
    Eur J Nutr 41:119-24. 2002
    ..alpha-CEHC (2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman) and gamma-CEHC (2,7,8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman) have been identified as water-soluble metabolites which are excreted with the urine in humans...
  63. pmc Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 297:L912-9. 2009
    ....
  64. ncbi In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication in the rat
    F Usuki
    Department of Clinical Medicine, National Institute for Minamata Disease, 4058 18 Hama, Minamata 867 0008, Japan
    Neurosci Lett 304:199-203. 2001
    ..These data indicate that MeHg-mediated oxidative stress plays an important role in the in vivo pathological process of MeHg intoxication. Trolox may prevent some of clinical manifestations of MeHg-intoxication in humans...
  65. ncbi γ-Tocotrienol induces apoptosis in human T cell lymphoma through activation of both intrinsic and extrinsic pathways
    Chandan Wilankar
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
    Curr Pharm Des 17:2176-89. 2011
    ..Our results show antitumor effects of GT in human lymphoma cells via increased mitochondrial ROS generation and activation of both intrinsic and extrinsic apoptotic pathways...
  66. ncbi Effect of either gamma-tocotrienol or a tocotrienol mixture on the plasma lipid profile in hamsters
    D Raederstorff
    Department of Vitamin and Nutrition Research, Roche Vitamins Ltd, CH 4070 Basel, Switzerland
    Ann Nutr Metab 46:17-23. 2002
    ..5% alpha-T3, 3.3% beta-T3, 41.4% gamma-T3, 0.1% delta-T3: mix-T3) on the plasma lipid profile in hamsters receiving a high fat diet...
  67. ncbi Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human
    Katalin Jemnitz
    Department of Pharmacobiochemistry, Institute of Biomolecular Chemistry, Chemical Research Center of HAS, Budapest, Hungary
    Toxicol Sci 115:80-8. 2010
    ..We conclude that in rats, the higher rate of basolateral bile salt efflux represents an additional protective mechanism in cholestasis, which contributes to species differences in response to hepatotoxic drugs...
  68. ncbi gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Anticancer Res 30:2869-74. 2010
    ..Differential growth responses among different types of tocotrienols have been observed in breast cancer cells; however, specific bioactivity of each individual tocotrienol remains to be elucidated...
  69. ncbi PPARgamma agonists attenuate proliferation and modulate Wnt/beta-catenin signalling in melanoma cells
    Aaron G Smith
    The University of Queensland, Institute for Molecular Bioscience, QLD 4072, Australia
    Int J Biochem Cell Biol 41:844-52. 2009
    ..Moreover, our data indicate that PPARgamma modulates Wnt/beta-catenin mediated signalling in melanoma cells in an agonist dependent manner...
  70. ncbi Induction of apoptosis by γ-tocotrienol in human cancer cell lines and leukemic blasts from patients: dependency on Bid, cytochrome c, and caspase pathway
    Akiko Inoue
    Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan
    Nutr Cancer 63:763-70. 2011
    ..Toc3 may have a role in cancer prevention and potential for treating hematological malignancies...
  71. ncbi Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor
    Delphine Gras
    Service des Maladies Respiratoires, Institut National de la Santé et de la Recherche Médicale Unité 454, Centre Hospitalier Universitaire Montpellier, France
    Am J Physiol Lung Cell Mol Physiol 296:L970-8. 2009
    ..This study provides evidence for the proliferative effect of anti-diabetic drug TZDs in nonmalignant human bronchial epithelial cells through GPR40 receptor activation, involving an intracellular Ca(2+) signaling pathway...
  72. ncbi Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells
    C E Clay
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1042, USA
    J Investig Med 49:413-20. 2001
    ..These data may explain, at least in part, some of the discordant results previously reported...
  73. ncbi New troglitazone derivatives devoid of PPARγ agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines
    Christelle Colin
    EA 4421 Signalisation, Genomique et Recherche Translationnelle en Oncologie, Faculte des Sciences, Universite Henri Poincare, Nancy Universite, BP 70239, 54506 Vandoeuvre les Nancy Cedex, France
    Breast Cancer Res Treat 124:101-10. 2010
    ..This should be taken into account for the design of new thiazolidinedione derivatives able to affect not only hormone-dependent but also hormone-independent breast cancer cells in a PPARγ-independent pathway...
  74. pmc Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 23:7222-9. 2003
    ....
  75. ncbi Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo
    Yoshimi Nakajima
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Brain Res 1226:226-33. 2008
    ..To investigate the neuroprotective effects of coenzyme Q10 and/or a vitamin E analogue on retinal damage both in vitro and in vivo...
  76. ncbi Protection of the kidney by thiazolidinediones: an assessment from bench to bedside
    P A Sarafidis
    Department of Preventive Medicine, Hypertension Clinical Research Center, Rush University Medical Center, Chicago, Illinois 60612, USA
    Kidney Int 70:1223-33. 2006
    ..This paper summarizes all the data from clinical and experimental studies relevant to a possible renoprotective effect of TZDs and discusses actions of these compounds that may contribute toward this effect...
  77. ncbi Rate- and site-dependent effects of propafenone, dofetilide, and the new I(Ks)-blocking agent chromanol 293b on individual muscle layers of the intact canine heart
    A Bauer
    Department of Cardiology, University of Heidelberg, Germany
    Circulation 100:2184-90. 1999
    ..Thus, this study was designed to determine whether the in vivo canine heart exhibits regional differences in left ventricular refractoriness and in the susceptibility to sodium and potassium channel blockers...
  78. ncbi Troglitazone (Rezulin) and hepatic injury
    G A Faich
    Pharmaceutical Assessments, Inc, 104 Foxhall Lane, Narberth, PA 19072, USA
    Pharmacoepidemiol Drug Saf 10:537-47. 2001
    ..Analyze US rates of reported severe liver disease for the oral hypoglycemic agent troglitazone from March 1997 through February 2000 and the possible effects of publicity on reporting...
  79. ncbi Inhibitory activity of flavonoids from Prunus davidiana and other flavonoids on total ROS and hydroxyl radical generation
    Hyun Ah Jung
    Faculty of Food Science and Biotechnology, Pukyong National University, Busan 608 737, Korea
    Arch Pharm Res 26:809-15. 2003
    ..Also, the presence of an ortho-hydroxyl group, whether on the A-ring or B-ring, and a 3-hydroxyl group on the C-ring increased the inhibitory activity on both total ROS and *OH generation...
  80. ncbi Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study
    Harold J Burstein
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Breast Cancer Res Treat 79:391-7. 2003
    ..To evaluate the therapeutic effects of the peroxisome proliferator-activated receptor (PPAR) gamma activating ligand, troglitazone, in patients with refractory metastatic breast cancer...
  81. ncbi The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway
    Kyung Hee Chun
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:3826-32. 2003
    ..Further investigation of the potential of SHetA2 in prevention and therapy of HNSCC is warranted also because of much lower toxicities compared with receptor active retinoids...
  82. ncbi Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells
    Sumit J Shah
    School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209 0470, USA
    Biochem Cell Biol 83:86-95. 2005
    ..In summary, these findings clearly demonstrate that tocotrienol-induced apoptosis occurs independently of mitochondrial stress apoptotic signaling in neoplastic +SA mammary epithelial cells...
  83. ncbi Loss-of-function mutations in PPAR gamma associated with human colon cancer
    P Sarraf
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 3:799-804. 1999
    ..These data indicate that colon cancer in humans is associated with loss-of-function mutations in PPAR gamma...
  84. pmc Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    E Elstner
    Division of Hematology Oncology, University of California Los Angeles School of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048 0750, USA
    Proc Natl Acad Sci U S A 95:8806-11. 1998
    ..Taken together, this combination may provide a novel, nontoxic and selective therapy for human breast cancers...
  85. ncbi Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma
    Chung Wai Shiau
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, Ohio, USA
    Cancer Res 65:1561-9. 2005
    ....
  86. ncbi Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists
    Doris M Benbrook
    Departments of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Invest New Drugs 23:417-28. 2005
    ..In conclusion, Flex-Hets exhibit improved therapeutic ratios for multiple cancer types over RAR and/or RXR agonists...
  87. ncbi Inhibition of cell invasion and morphological change by troglitazone in human pancreatic cancer cells
    Wataru Motomura
    Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    J Gastroenterol 39:461-8. 2004
    ..The present study was performed to clarify the role of PPARgamma in cell invasion/motility in human pancreatic cancer cells...
  88. ncbi Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells
    Dennis Bruemmer
    Division of Endocrinology, Diabetes and Hypertension and The Gonda Goldschmied Diabetes Center, David Geffen School of Medicine, University of California, Los Angeles, Calif 90095, USA
    Circ Res 93:e38-47. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  89. ncbi Clinical pharmacokinetics of troglitazone
    C M Loi
    Department of Pharmacokinetics, Dynamics and Metabolism, Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    Clin Pharmacokinet 37:91-104. 1999
    ..Knowledge of systemic troglitazone exposure within a dose group does not improve the prediction of glucose lowering response or adverse effects beyond those based on the administered dose...
  90. ncbi Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor gamma-independent mechanism in breast cancer-derived cell lines
    Francesco Turturro
    Department of Medicine, Feist Weiller Cancer Center, Gene Therapy Program, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Clin Cancer Res 10:7022-30. 2004
    ....
  91. ncbi Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells
    Katherine L Schaefer
    Section of Gastroenterology, Boston Medical Center, Boston, MA 02118, USA
    Cancer Res 65:2251-9. 2005
    ..Inhibition of PPARgamma function causes HCC cell death by preventing adhesion and inducing anoikis-mediated apoptosis. PPARgamma inhibitors represent a potential novel treatment approach to HCC...
  92. ncbi Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells
    Fen Yin
    Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, California, CA 90095, USA
    Oncogene 23:4614-23. 2004
    ..Our finding of GADD45 induction by TRO may provide a new insight concerning the mechanisms for TRO's antiproliferative and pro-apoptotic effects in breast cancer cells...
  93. ncbi Peroxisome proliferator-activated receptor gamma1 (PPARgamma1) expresses in rat mesangial cells and PPARgamma agonists modulate its differentiation
    T Asano
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3 1 1, Higashi ku, 812 8586, Fukuoka, Japan
    Biochim Biophys Acta 1497:148-54. 2000
    ..These results indicate that PPARgamma1 is expressing in rat mesangial cells, and PPARgamma1 activation with its agonists modulates the proliferation and differentiation of cultured rat mesangial cells...
  94. ncbi PPARgamma agonists enhance human vascular endothelial adhesiveness by increasing ICAM-1 expression
    N G Chen
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Biochem Biophys Res Commun 263:718-22. 1999
    ..These findings suggest that the PPARgamma signaling pathway might contribute to the atherogenicity of oxLDL in vascular endothelial cells...
  95. ncbi Peroxisome proliferator-activated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2
    Shu Wakino
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Circ Res 95:e45-55. 2004
    ..The full text of this article is available online at http://circres.ahajournals.org...
  96. ncbi Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells
    Jiajun Liu
    Department of Haematology and Oncology, The Third Affiliated Hospital of Sun Yat Sen University, Guangdong Guangzhou, 510630, P R China
    Cancer Chemother Pharmacol 56:400-8. 2005
    ..The data suggest that PPAR-gamma ligands may serve as potential anti-leukemia reagents...
  97. ncbi Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Cancer Res 61:2424-8. 2001
    ..Our results suggest that synthetic PPARs ligands (PPARalpha and PPARgamma) can inhibit the early stages of colon tumorigenesis with or without colitis...
  98. ncbi Troglitazione affects survival of human osteosarcoma cells
    Enrico Lucarelli
    Laboratory of Oncology Research, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Cancer 98:344-51. 2002
    ..Our work describes a new function for TRO and indicates that the Akt survival pathway may be a mediator of TRO-induced increase of survival...
  99. ncbi Troglitazone and pioglitazone interactions via PPAR-gamma-independent and -dependent pathways in regulating physiological responses in renal tubule-derived cell lines
    Francesco Turturro
    Dept of Medicine, Feist Weiller Cancer Center, Louisiana State University Health Science Center, Shreveport, LA 71130, USA
    Am J Physiol Cell Physiol 292:C1137-46. 2007
    ..Our findings provide a model both for understanding seemingly opposite biological effects and for enhancing therapeutic potency of these agents...
  100. ncbi 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells
    K Takeda
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, 812-8582 Fukuoka, Japan
    J Biol Chem 276:48950-5. 2001
    ..These findings indicate a novel regulatory mechanism of gene expression by 15-d-PGJ2 and thiazolidinediones...
  101. ncbi Dietary phenolic antioxidants, caffeic acid and Trolox, protect rainbow trout gill cells from nitric oxide-induced apoptosis
    Mi Ja Chung
    King s College London, Nutritional Sciences Research Division, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
    Aquat Toxicol 80:321-8. 2006
    ..Because of these properties we suggest that CA could be a beneficial additive to fish feeds in aquaculture...

Research Grants68

  1. Design and development of 5-HT7 receptor agonists
    Mikhail L Bondarev; Fiscal Year: 2013
    ..of four major classes of selective and nonselective 5-HT7 receptor agonists: arylpiperazines, aminotetralins/chromans, thiopyridines, and 2-anilinoimidazolines...
  2. SYNTHESIS OF BIOLOGICALLY IMPORTANT DIHYDROBENZOFURANS
    Thomas Engler; Fiscal Year: 1991
    ..various alkenes and cyclopropanes with methoxy-1,4-benzoquinones to selectively yield dihydrobenzofurans A-C and chromans D-F, respectively...
  3. Catalytic Asymmetric Synthesis of Vinyl Chromans Using Palladium(II) Catalysts
    ANGELA CHRISTINE OLSON; Fiscal Year: 2010
    ..proposal describes the development of a mild and efficient method for the catalytic asymmetric synthesis of vinyl chromans. The chroman motif is present in numerous small molecules of biological importance and the current methods ..
  4. Modulators of Nicotine-Mediated Dopamine Release
    Simon Efange; Fiscal Year: 2003
    ..Specifically, we propose to synthesize 8 related substituted chromans and coumarins...
  5. NATURAL VITAMIN E FORMS AS ANTI-INFLAMMATORY DRUGS
    Qing Jiang; Fiscal Year: 2006
    ..abstract_text> ..
  6. SIGNAL TRANSDUCTION SYSTEMS IN ALZHEIMERS DISEASE
    Gary Gibson; Fiscal Year: 2003
    ..abstract_text> ..
  7. Mitochondiral enzymes/oxidative stress in Alzheimer's
    Gary Gibson; Fiscal Year: 2004
    ..These models will also provide systems to test the efficacy of approaches to limit or reverse the changes in mitochondria. ..
  8. Steroids and Stem Cell in Carcinogenesis
    Doris Benbrook; Fiscal Year: 2004
    ..This research will enhance our understanding of the process of carcinogenesis and chemoprevention, which could ultimately translate into strategies and pharmaceuticals for prevention of cancer. ..
  9. Mechanism of SHeA2 Action in Ovarian Cancer
    Doris Benbrook; Fiscal Year: 2009
    ..The elucidation of the proteins involved in the SHetA2 pathwayswill provide potential biomarkers for ovarian cancer diagnosis, prevention and treatment strategies. ..
  10. Oxidative Stress and Vitamin E Requirements
    Maret Traber; Fiscal Year: 2005
    ..These proposed studies will further our goal of understanding the role of vitamin E in the amelioration of oxidative damage in aging and in chronic diseases, such as heart disease, diabetes and cancer. ..
  11. Alpha-Tocopherol Modulation of Xenobiotic Metabolism
    Maret Traber; Fiscal Year: 2009
    ..We believe that our findings may well have a significant impact on current self-medication practices of the millions of Americans currently taking prescription drugs and vitamin E supplements. ..
  12. AGE/NUTRITION/GENES IN MODELS OF PSYCHIATRIC DISORDERS
    Gary Gibson; Fiscal Year: 2007
    ..An understanding of these mechanisms will likely suggest new ways to overcome the consequences of the mild, chronic impairment of oxidative metabolism that accompanies numerous age-related neurodegenerative disorders. ..
  13. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  14. Mechanisms of Vitamin E Function Studied in Zebrafish
    Maret G Traber; Fiscal Year: 2010
    ..the molecular targets altered by - tocopherol-deficiency in the zebrafish will provide a solid basis for understanding why humans require -tocopherol for reproduction as well as to maintain a healthy nervous system ..
  15. Antioxidant Supplementation,Oxidative Stress & Enduranc*
    Maret Traber; Fiscal Year: 2002
    ..Finally, the investigators plan to measure markers of inflammatory response, such as C-oxidants increase and vitamin E decreases these markers. ..
  16. Glycogen Metabolism in Hypoglycemia Counterregulation
    Ilan Gabriely; Fiscal Year: 2007
    ..These experiments will involve the combined use of sophisticated metabolic physiology and state-of-the-art 4 Tesla NMR spectroscopy to understand the mechanisms of defective glucose counterregulation. ..
  17. Training Program in Host Pathogen Interactions
    Paul Skolnik; Fiscal Year: 2006
    ..abstract_text> ..
  18. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2007
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  19. Institutional Clinical /Translational Science Awards
    John Clore; Fiscal Year: 2006
    ..Formal process and summative evaluation will ensure that planning milestones are met in preparation for submission of the U54 proposal. [unreadable] [unreadable] [unreadable]..
  20. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2006
    ..abstract_text> ..
  21. Glutathione transport, oxidative stress and lung injury
    Brian Day; Fiscal Year: 2007
    ..air pollutants in sensitive populations with pre-existing lung disease, since a large number of pulmonary diseases (including COPD, ARDS, asthma and pulmonary fibrosis) also have deficits pulmonary ELF GSH [unreadable] [unreadable]..
  22. Modeling of Lung HIV Cytokine/Chemokine Networks
    Paul Skolnik; Fiscal Year: 2006
    ..Identification of the most central molecules in these linked systems may suggest new therapeutic or vaccine approaches to bolster the host immune response to HIV. ..
  23. Continuation of Dialysis Access Consortium Clinical Trials
    Jonathan Himmelfarb; Fiscal Year: 2007
    ..The health care cost o maintaining adequate vascular access should also decrease from its current rate of over one billion dollars per year. ..
  24. C/EBP BETA IN HEPATOCYTE GENE EXPRESSION & PROLIFERATION
    Mario Chojkier; Fiscal Year: 2002
    ....
  25. Growth factor effects on dental pulp cells
    DOUGLAS LOBNER; Fiscal Year: 2008
    ..As a method of maintaining the viability of these cells we are proposing studying the effects of naturally occurring substances called growth factors on dental pulp cells. [unreadable] [unreadable] [unreadable]..
  26. Intermediate Filaments 2008 Gordon Research Conference
    Thomas Shea; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Molecular Basis of Automaticity in the Myometrium
    Glenna Bett; Fiscal Year: 2008
    ..Identification of an ion channel which is the uterine pacemaker offers the opportunity for designing interventions to prevent and delay preterm labor. [unreadable] [unreadable] [unreadable] [unreadable]..
  28. Role of Insulin Regulation of Beta Cell Function in Vivo and in Vitro
    Allison Goldfine; Fiscal Year: 2008
    ..These studies may provide a unifying explanation linking the combined defects in insulin secretion and action that underlie type 2 diabetes. ..
  29. Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  30. Mitochondrial Dysfunction and Drug Hepatotoxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2010
    ..This new insight into the signaling mechanism of AAP-induced cell death holds the promise of establishing novel therapeutic approaches for preventing AAP-induced liver failure and potentially other forms of drug toxicity in humans. ..
  31. Protective Efficacy of Mg-Supplementation Against NRTI-induced Cardiac Toxicity
    IVAN MAK; Fiscal Year: 2007
    ..This proposed exploratory effort may reveal a potential usefulness of Mg-supplements as an effective, yet relatively inexpensive adjunct therapy to lessen NRTI-related cardiovascular toxicity. ..
  32. FURANOCOUMARINS AND DRUGS EFFECT ON CYP3A4
    Paul Watkins; Fiscal Year: 2007
    ..abstract_text> ..
  33. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    VIRGINIA PICKEL; Fiscal Year: 2007
    ..unreadable] Together, the results will contribute to our understanding of the[unreadable] pathophysiology and treatment of hyperkinetic movement disorders and[unreadable] schizophrenia. ..
  34. Genetic variation in drug targets for type 2 diabetes
    Jose Florez; Fiscal Year: 2008
    ..This proposal should serve as the foundation for a large pharmacogenomics trial designed to evaluate the feasibility of genetically-tailored therapy in T2DM. ..
  35. Role of Oxidatve Stress in Chronic Beryllium Disease
    Brian Day; Fiscal Year: 2006
    ..These studies have the potential to further define the etiology of CBD, risk factors, and suggest novel approaches to prevent and treat this disease. ..
  36. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  37. MECHANISMS OF INJURY POTENTIATION BY GROWTH FACTORS
    DOUGLAS LOBNER; Fiscal Year: 2004
    ..It is believed that these studies will aid in determining under what conditions growth factor induced potentiation of cell death may be of concern regarding their therapeutic use, and how those concerns may be addressed. ..
  38. B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAIL
    HOWARD HODIS; Fiscal Year: 2004
    ..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
  39. PHYSIOLOGY AND MOLECULAR DETERMINANTS OF DIABETES
    Allison Goldfine; Fiscal Year: 2004
    ....
  40. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  41. Nanospheres as Vehicles for Treatment of Neuroblastoma
    Thomas Shea; Fiscal Year: 2004
    ..Resulting data will indicate whether or not nanospheres represent useful delivery agents for cancer therapy. ..
  42. Lung TACE, TNFalpha & TNFR Regulation of HIV Replication
    Paul Skolnik; Fiscal Year: 2002
    ..This hypothesis-driven project will suggest whether anti-TNF or anti-TACE therapies will improve immunologic function and virologic control in HIV-infected persons receiving HAART. ..
  43. TCR USAGE AND FUNCTION IN IBD
    Lawrence Saubermann; Fiscal Year: 2003
    ..These strategies, which are based on rapidly emerging technologies, will aim to define the cognate antigen(s) of these potentially disease relevant T-cells, and thus allow further insight into the etiopathogenesis of IBD. ..
  44. Peptide antigens in CD45RBhigh CD4+T cell colitis model
    Lawrence Saubermann; Fiscal Year: 2003
    ..Potentially, by this approach, antigens responsible for CD45RBhigh CD4plus T cell adoptive transfer model of colitis can be elucidated, this may lead to a better understanding of human inflammatory bowel disease. ..
  45. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
  46. Apoptotic Mechanisms of Tocotrienols in Mammary Cancer
    Paul Sylvester; Fiscal Year: 2004
    ..Although caspase-8 activation is associated with death receptor signaling, the exact receptor/ligand signaling mechanism(s) mediating tocotrienol-induced caspase-8 activation has not been determined. ..
  47. Screen for Mycobacterium Tuberculosis (RMI)
    E White; Fiscal Year: 2005
    ..tuberculosis. 3) To study the effect of these novel inhibitors on the pantothenate pathway in M. smegmatis. 4) To co-crystallize these compounds with pantothenate synthetase to study their mode of binding ..
  48. IMAGING TRANSMISSION ELECTRON MICROSCOPE
    VIRGINIA PICKEL; Fiscal Year: 2001
    ..abstract_text> ..
  49. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  50. HYDROXYNONENAL MODIFICATION OF SUPEROXIDE DISMUTASE
    Kenneth Hensley; Fiscal Year: 2002
    ..abstract_text> ..
  51. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  52. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2004
    ..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..
  53. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2004
    ..Therefore, the risks and benefits of a CCOCP regimen are an important women's health issue that warrant investigation. ..
  54. Regulation of syndecan 1 in by n-3 PUFA
    IRIS EDWARDS; Fiscal Year: 2009
    ..abstract_text> ..
  55. Protein alterations in skeletal muscle cells with improved mtDNA repair
    Lyudmila I Rachek; Fiscal Year: 2010
    ..To complete this study we propose to make use of a new liquid chromatography tandem mass spectrometry (LC-MS/MS) approach. ..
  56. PPARGamma in Sepsis-Induced Immunosuppression
    Raju Reddy; Fiscal Year: 2006
    ..abstract_text> ..
  57. Contraceptive in Women with Prior Gestational Diabetes
    Anny Xiang; Fiscal Year: 2005
    ..The observational results will also be important to the design of future direct comparisons of different forms of contraception in this high-risk population. ..
  58. Pharmacogenetics of the acute response to sulfonylurea and metformin treatment in
    Jose Florez; Fiscal Year: 2008
    ..In addition, this pilot study will lay the groundwork for a long-term, outcomes-based pharmacogenetic clinical trial. [unreadable] [unreadable]..
  59. Novel Celecoxib Derivatives as Chemopreventive Agents
    Ching Shih Chen; Fiscal Year: 2005
    ..In parallel, we will examine the safety of chronic oral treatment with these compounds in non-carcinogen-treated tumor-free animals. ..
  60. DEVELOPMENT OF A MODEL TO PREDICT DRUG HEPATOTOXICITY
    KIM BROUWER; Fiscal Year: 2005
    ..g., dog, monkey) as well as from humans is a particularly attractive feature of this novel in vitro model, and will be developed during the scale-up phase of this model system in a subsequent R33 application. ..
  61. Apoptosis Regulation by Lipid Signals in Prostate Cancer
    Ching Shih Chen; Fiscal Year: 2005
    ..Identification of new anti-cancer agents whose mode of action is distinct from existing chemotherapeutic regimens will foster new therapeutic strategies. ..
  62. Mechanisms of Neutrophil-induced Liver Toxicity
    Hartmut Jaeschke; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. Novel Function of PI 3-Kinase in Calcium Regulation
    Ching Shih Chen; Fiscal Year: 2004
    ..These studies will help understand how the PI(3,4,5)P3-binding protein mediates Ca2+ entry across the plasma membrane. ..
  64. Testing of Novel Apoptotic Agents in Prostate Cancer
    Ching Shih Chen; Fiscal Year: 2002
    ..Together, these animal-- model studies will validate that the in vitro apoptosis-inducing effect of these compounds is relevant for tumor growth inhibition in vivo. ..