aflatoxin b1

Summary

Summary: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.

Top Publications

  1. ncbi In-house direct cELISA for determining aflatoxin B1 in Thai corn and peanuts
    S Lipigorngoson
    Department of Biochemistry and Food Science, Faculty of Agriculture, Kagawa University, Miki, Kagawa 761 0795, Japan
    Food Addit Contam 20:838-45. 2003
  2. ncbi Aflatoxin B1 in poultry: toxicology, metabolism and prevention
    Sumit Rawal
    Graduate Program in Toxicology, Department of Veterinary Sciences, Utah State University, Logan, UT 84322 4620, USA
    Res Vet Sci 89:325-31. 2010
  3. ncbi Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells
    Veronica S Mary
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI, CONICET, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Córdoba X5000HUA, Argentina
    Toxicology 302:299-307. 2012
  4. ncbi Systems responses of rats to aflatoxin B1 exposure revealed with metabonomic changes in multiple biological matrices
    Limin Zhang
    State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, P R China
    J Proteome Res 10:614-23. 2011
  5. ncbi The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes
    L Alpsoy
    Fatih University, Faculty of Art and Science, Department of Biology, Istanbul, Turkey
    Toxicol Ind Health 25:121-7. 2009
  6. ncbi Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells
    Xue Jiao Yang
    Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, PR China
    Toxicology 300:138-48. 2012
  7. ncbi XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency
    R M Lunn
    Laboratory of Computational Biology and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 59:2557-61. 1999
  8. pmc Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression
    Kerstin Gross-Steinmeyer
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 116:422-32. 2010
  9. ncbi Genetic polymorphisms in DNA repair genes XRCC4 and XRCC5 and aflatoxin B1-related hepatocellular carcinoma
    Xi Dai Long
    Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P R China
    Epidemiology 24:671-81. 2013
  10. ncbi Immunotoxicity of aflatoxin B1: impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression
    Guylaine M Meissonnier
    Laboratoire de Pharmacologie Toxicologie UR66, INRA, F 31931 Toulouse, France
    Toxicol Appl Pharmacol 231:142-9. 2008

Detail Information

Publications294 found, 100 shown here

  1. ncbi In-house direct cELISA for determining aflatoxin B1 in Thai corn and peanuts
    S Lipigorngoson
    Department of Biochemistry and Food Science, Faculty of Agriculture, Kagawa University, Miki, Kagawa 761 0795, Japan
    Food Addit Contam 20:838-45. 2003
    ..Mean levels of AFB(1) (per cent positive) were 73 microg kg(-1) (85.7%) in corn and 102 microg kg(-1) (67.9%) in peanuts, for which 46.4% of both foods were above the Thailand regulation limit (20 microg kg(-1))...
  2. ncbi Aflatoxin B1 in poultry: toxicology, metabolism and prevention
    Sumit Rawal
    Graduate Program in Toxicology, Department of Veterinary Sciences, Utah State University, Logan, UT 84322 4620, USA
    Res Vet Sci 89:325-31. 2010
    ..The most important AF in terms of toxic potency and occurrence is aflatoxin B1 (AFB1)...
  3. ncbi Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells
    Veronica S Mary
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI, CONICET, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Córdoba X5000HUA, Argentina
    Toxicology 302:299-307. 2012
    b>Aflatoxin B1 (AFB(1)) and fumonisin B1 (FB(1)) are mycotoxins widely found as cereal contaminants...
  4. ncbi Systems responses of rats to aflatoxin B1 exposure revealed with metabonomic changes in multiple biological matrices
    Limin Zhang
    State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, P R China
    J Proteome Res 10:614-23. 2011
    ..These findings provide an overview of biochemical consequences of AFB1 exposure and comprehensive insights into the metabolic aspects of AFB1-induced hepatotoxicity in rats...
  5. ncbi The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes
    L Alpsoy
    Fatih University, Faculty of Art and Science, Department of Biology, Istanbul, Turkey
    Toxicol Ind Health 25:121-7. 2009
    ..Simultaneous supplementation with vitamin A, C, and E restored these parameters to that of normal range. In conclusion, vitamin A, C, and E exhibited protective effects in human lymphocytes by inhibiting AFB(1)-induced ROS generation...
  6. ncbi Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells
    Xue Jiao Yang
    Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, PR China
    Toxicology 300:138-48. 2012
    ..Collectively, these findings suggest adverse effects of AFB(1) in respiratory diseases mediated by CYP2A13...
  7. ncbi XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency
    R M Lunn
    Laboratory of Computational Biology and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 59:2557-61. 1999
    ..enzyme, XRCC1 (codons 194, 280, and 399), and genotoxic end points measured in two populations: (a) placental aflatoxin B1 DNA (AFB1-DNA) adducts in a group of Taiwanese maternity subjects (n = 120); and (b) somatic glycophorin A (GPA)..
  8. pmc Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression
    Kerstin Gross-Steinmeyer
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 116:422-32. 2010
    ..The downregulation of CYP3A4 by SFN may have important implications for drug interactions...
  9. ncbi Genetic polymorphisms in DNA repair genes XRCC4 and XRCC5 and aflatoxin B1-related hepatocellular carcinoma
    Xi Dai Long
    Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P R China
    Epidemiology 24:671-81. 2013
    ..We investigated the role of genetic polymorphisms at XRCC4 codon 247 (rs3734091, XRCC4P) and XRCC5 codon 180 (rs80309960, XRCC5P) in liver cancer (hepatocellular carcinoma) caused by aflatoxin B1 (AFB1).
  10. ncbi Immunotoxicity of aflatoxin B1: impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression
    Guylaine M Meissonnier
    Laboratoire de Pharmacologie Toxicologie UR66, INRA, F 31931 Toulouse, France
    Toxicol Appl Pharmacol 231:142-9. 2008
    b>Aflatoxin B1 (AFB1), a mycotoxin produced by Aspergillus flavus or A. parasiticus, is a frequent contaminant of food and feed. This toxin is hepatotoxic and immunotoxic...
  11. ncbi Metabolism of aflatoxin B1 in turkey liver microsomes: the relative roles of cytochromes P450 1A5 and 3A37
    Sumit Rawal
    Graduate Toxicology Program, and Department of Veterinary Sciences, School of Veterinary Medicine, Utah State University, Logan, UT 84322, USA
    Toxicol Appl Pharmacol 254:349-54. 2011
    ..The data support the conclusion that P450 1A5 is the dominant enzyme responsible for AFB(1) bioactivation and metabolism at environmentally-relevant AFB(1) concentrations in turkey liver...
  12. pmc Aflatoxin B1 exposure, hepatitis B virus infection, and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 630 West 168th Street, RM19 418, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 18:846-53. 2009
    To evaluate the role of aflatoxin B1 (AFB1) exposure on risk of hepatocellular carcinoma (HCC), a case-control study nested within a community-based cohort was conducted...
  13. ncbi Hepatic aflatoxin B1-DNA adducts and TP53 mutations in patients with hepatocellular carcinoma despite low exposure to aflatoxin B1 in southern Japan
    Ken Shirabe
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Liver Int 31:1366-72. 2011
    Hepatitis B or C virus infection is considered to be the main cause of hepatocellular carcinoma (HCC) in Japan. Aflatoxin B1 (AFB1) is a carcinogen associated with HCC in regions with high exposure...
  14. ncbi Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure
    Pascal Pineau
    Unité d Organisation Nucléaire et Oncogénèse, INSERM U579, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mutat Res 653:6-13. 2008
    ..This instability is considered to be caused primarily by Hepatitis B virus (HBV), although aflatoxin B1 (AFB1), a potent fungal mutagen is also suspected to influence chromosomal repair...
  15. ncbi Polymorphisms in the coding region of X-ray repair complementing group 4 and aflatoxin B1-related hepatocellular carcinoma
    Xi Dai Long
    Department of Liver Surgery, the Affiliated Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Hepatology 58:171-81. 2013
    ..the role of polymorphisms in the coding region of this gene in hepatocellular carcinoma (HCC) caused by aflatoxin B1 (AFB1)...
  16. ncbi Chemical composition, antifungal and antiaflatoxigenic activities of Ocimum sanctum L. essential oil and its safety assessment as plant based antimicrobial
    Ashok Kumar
    Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi 221005, India
    Food Chem Toxicol 48:539-43. 2010
    ..3 and 0.2 microl ml(-1), respectively. The O. sanctum EO and eugenol also inhibited the aflatoxin B1 production completely at 0.2 and 0.1 microl ml(-1), respectively...
  17. pmc RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1
    C A Reed
    Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107 5541, USA
    Oncogene 28:4434-43. 2009
    ..In particular, exposure to the genotoxic hepatocarcinogen aflatoxin B1 (AFB1) is a significant factor in the genesis of human liver cancer...
  18. pmc In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure
    Ahmad Besaratinia
    Department of Cancer Biology, Beckman Research Institute of the City of Hope National Medical Center, Duarte, California 91010, USA
    Gastroenterology 137:1127-37, 1137.e1-5. 2009
    ..HCCs from AFB(1)-exposed individuals frequently have distinct TP53 mutations, such as G to T transversions in the second guanine of codon 249 (AGG to AGT), and a characteristic mutational spectrum predominated by G:C to T:A mutations...
  19. ncbi Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells
    Caroline Aninat
    Institut National de la Santé et de la Recherche Médicale INSERM U620, Universite de Rennes 1, France
    Drug Metab Dispos 34:75-83. 2006
    ....
  20. ncbi Aflatoxin B1-induced DNA damage and its repair
    Leanne L Bedard
    Department of Pharmacology and Toxicology, Queen s University, Botterell Hall, Kingston, Ont, Canada K7L 3N6
    Cancer Lett 241:174-83. 2006
    ..Furthermore, DNA repair activity and modulation of repair by AFB(1) seem to be major determinants of susceptibility to AFB(1)-induced carcinogenesis...
  21. ncbi Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians
    Yi Jiang
    Department of Epidemiology and International Health, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
    Int Immunol 17:807-14. 2005
    ..We examined the cellular immune status of 64 Ghanaians in relation to levels of aflatoxin B1 (AFB1)-albumin adducts in plasma...
  22. ncbi The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis
    M E Smela
    Department of Chemistry and Division of Bioengineering and Environmental Health Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Carcinogenesis 22:535-45. 2001
    ..In addition, epidemiological and experimental data are examined regarding the synergistic effects of AFB(1) and HBV on HCC formation and the predominance of one hotspot GC-->TA transversion in the p53 gene of affected individuals...
  23. ncbi Effect of aflatoxin B1 on CD3 T cells and alkaline phosphatase in the intestine of mice
    I Tomkova
    University of Veterinary Medicine, Kosice, Slovak Republic
    Mycopathologia 154:15-9. 2002
    The aim of the study was to determine the effect of repeated applications of aflatoxin B1 (AFB1) on immunocompetent cells (CD3 T cells) and alkaline phosphatase in the intestinal mucosa. Mice were orally treated with AFB1 for 24 days...
  24. ncbi Detoxification of aflatoxin B1 by manganese peroxidase from the white-rot fungus Phanerochaete sordida YK-624
    Jianqiao Wang
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan
    FEMS Microbiol Lett 314:164-9. 2011
    ..This is the first report that MnP can effectively remove the mutagenic activity of AFB(1) by converting it into AFB(1) -8,9-dihydrodiol...
  25. ncbi Cytotoxicity and genotoxicity induced by aflatoxin B1, ochratoxin A, and their combination in cultured Vero cells
    Emna El Golli-Bennour
    Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir 5000, Tunisia
    J Biochem Mol Toxicol 24:42-50. 2010
    b>Aflatoxin B1 (AFB1) and ochratoxin A (OTA) are important food-borne mycotoxins that have been implicated in human health...
  26. ncbi Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: aflatoxin B1 (AFB1)
    Diane Benford
    Food Standards Agency, UK
    Food Chem Toxicol 48:S34-41. 2010
    b>Aflatoxin B1 (AFB1) has been consistently shown to be a potent mutagen and is a liver carcinogen in humans and a wide range of animal species. The Fisher rat appears to be the most sensitive animal model...
  27. ncbi Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect
    Chia Hung Yen
    Division of Molecular Medicine, Institute of Public Health, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Toxicol Appl Pharmacol 235:296-304. 2009
    ..9 microM. Therefore, GNMT is a tumor suppressor for HCC and it exerts protective effects in hepatocytes via direct interaction with AFB(1), resulting in reduced AFB(1)-DNA adducts formation and cell death...
  28. ncbi Hepatic oval cell lines generate hepatocellular carcinoma following transfection with HBx gene and treatment with aflatoxin B1 in vivo
    Chang hai Li
    Hepatic Surgery Centre, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    Cancer Lett 311:1-10. 2011
    ..Studies have demonstrated that chronic hepatitis B virus (HBV) infection and dietary aflatoxin B1 (AFB1) exposure are among the most important risk factors for the development of hepatocellular carcinoma (HCC)...
  29. pmc Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1
    Zoran Ilic
    Ordway Research Institute, Albany, NY 12208, USA
    Toxicol Appl Pharmacol 242:241-6. 2010
    b>Aflatoxin B1 (AFB1) is a major risk factor for hepatocellular carcinoma (HCC) in humans...
  30. ncbi Structure, genetic mapping, and function of the cytochrome P450 3A37 gene in the turkey (Meleagris gallopavo)
    S Rawal
    Graduate Toxicology Program and Department of Veterinary Sciences, Utah State University, Logan, Utah 84322, USA
    Cytogenet Genome Res 125:67-73. 2009
    ..often responsible for the toxic and carcinogenic effects of natural food-borne toxicants, such as the mycotoxin aflatoxin B1 (AFB1)...
  31. ncbi Acetoxy-4-methylcoumarins confer differential protection from aflatoxin B(1)-induced micronuclei and apoptosis in lung and bone marrow cells
    H G Raj
    V P Chest Institute, University of Delhi, 110007, Delhi, India
    Mutat Res 494:31-40. 2001
    ..The relative number and position of acetoxy groups on the coumarin nucleus determine the specificity to the transacetylase necessary for the chemopreventive action...
  32. ncbi Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan
    C A Sun
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    Carcinogenesis 22:1289-94. 2001
    ..These results demonstrate the importance of gene-environment interactions in the multifactorial development of HCC...
  33. ncbi Protective role of methanol extract of Cetraria islandica (L.) against oxidative stress and genotoxic effects of AFB₁ in human lymphocytes in vitro
    Elif Kotan
    Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey
    Toxicol Ind Health 27:599-605. 2011
    ..dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MDA) levels against effects of aflatoxin B1 (AFB₁) induced oxidative stress and genotoxicity in human lymphocytes in vitro...
  34. ncbi Aflatoxin B1-induced Hprt mutations in splenic lymphocytes of Fischer 344 rats. Results of an intermittent feeding trial
    S M Morris
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Department of Health and Human Services, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 423:33-8. 1999
    ..phosphoribosyl transferase (Hprt) locus in the splenic lymphocytes of Fischer 344 rats acutely exposed to aflatoxin B1 (AFB1)...
  35. ncbi Aflatoxin B1 alters the expression of p53 in cytochrome P450-expressing human lung cells
    Terry R Van Vleet
    Graduate Program in Toxicology, and Department of Veterinary Sciences, Utah State University, Logan, UT 84322 4620, USA
    Toxicol Sci 89:399-407. 2006
    b>Aflatoxin B1 (AFB1) is a potent dietary hepatocarcinogen in animals and probably in humans. Mutations (and altered expression) of the tumor suppresser gene p53 have been observed in liver tumors from patients exposed to high dietary AFB1...
  36. pmc Comparative study on the aflatoxin B1 degradation ability of rumen fluid from Holstein steers and Korean native goats
    Santi Devi Upadhaya
    Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, College of Agriculture and Life Science, Seoul National University, Seoul 151 921, Korea
    J Vet Sci 10:29-34. 2009
    The aflatoxin B1 degrading abilities of two different ruminants were compared in this study. One set of experiments evaluated the aflatoxin B1 degradation ability of different rumen fluid donors (steers vs...
  37. ncbi Occurrence of Aspergillus spp. and aflatoxin B1 in Malaysian foods used for human consumption
    Kasa R N Reddy
    Plant Pathology and Mycology Laboratory, School of Biological Sciences, Univ Sains Malaysia, 11800 USM, Penang, Malaysia
    J Food Sci 76:T99-104. 2011
    ..Aspergillus spp. and AFB1 was not detected in any cookies tested. Although this survey was not comprehensive, it provides valuable information on aflatoxin levels in foods marketed in Malaysia...
  38. ncbi Associations of plasma aflatoxin B1-albumin adduct level with plasma selenium level and genetic polymorphisms of glutathione S-transferase M1 and T1
    S Y Chen
    Columbia University School of Public Health, New York, NY 10032, USA
    Nutr Cancer 38:179-85. 2000
    ..To investigate factors associated with plasma aflatoxin B1 (AFB1)-albumin adduct level, we studied 304 healthy adult residents from Matzu...
  39. ncbi Immunotoxicity of aflatoxin B1 in rats: effects on lymphocytes and the inflammatory response in a chronic intermittent dosing study
    Dennis M Hinton
    United States Food and Drug Association, Center for Food Safety and Applied Nutrition, Laurel, Maryland 20708, USA
    Toxicol Sci 73:362-77. 2003
    We investigated the effects of aflatoxin B1 (AFB1) on isolated splenic lymphocytes and the histo-morphologic changes in the spleens and liver of Fisher-344 male rats. Weaned animals were fed chow diets that contained 0, 0.01, 0.04, 0...
  40. pmc Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1
    K A McGlynn
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 92:2384-7. 1995
    b>Aflatoxin B1 (AFB1) has been postulated to be a hepatocarcinogen in humans, possibly by causing p53 mutations at codon 249...
  41. ncbi Effect of aflatoxin B1 on UDP-glucuronosyltransferase mRNA expression in HepG2 cells
    Nobumitsu Hanioka
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama 700 8530, Japan
    Chemosphere 89:526-9. 2012
    b>Aflatoxin B1 (AFB1) is a potent mycotoxin that induces hepatocellular carcinoma in many animal species, including humans...
  42. ncbi Effects of feeding corn naturally contaminated with aflatoxin B1 and B2 on hepatic functions of broilers
    J Yang
    Sichuan Agricultural University, Sichuan, China
    Poult Sci 91:2792-801. 2012
    ....
  43. pmc Physiologically based toxicokinetics of serum aflatoxin B1-lysine adduct in F344 rats
    Guoqing Qian
    Department of Environmental Health Science, The University of Georgia, Athens, GA 30602, USA
    Toxicology 303:147-51. 2013
    ....
  44. ncbi Etiological and molecular profile of hepatocellular cancer from India
    Mohammad Asim
    Department of Medicine, Maulana Azad Medical College, University of Delhi, New Delhi, India
    Int J Cancer 133:437-45. 2013
    ..High HBV-DNA levels and HBV/D increased the risk of HCC. However, neither genotype nor virus loads of HCV affected prognosis of HCC patients in our study...
  45. pmc Aflatoxin B(1) in affecting broiler's performance, immunity, and gastrointestinal tract: a review of history and contemporary issues
    Agha W Yunus
    Institute of Animal Nutrition, University of Veterinary Medicine Vienna, A 1210 Vienna, Austria
    Toxins (Basel) 3:566-90. 2011
    ..In addition to these issues, the metabolism of aflatoxin B(1) and recently proposed hypotheses regarding biphasic effects of the mycotoxin in broilers are briefly discussed...
  46. ncbi Influence of selenium on body weights and immune organ indexes in ducklings intoxicated with aflatoxin B₁
    Shining Guo
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
    Biol Trace Elem Res 146:167-70. 2012
    ..01). These results revealed that AFB(1) significantly affect ducklings' growth and immune organs development. However, selenium significantly ameliorated the negative effects induced by AFB(1)...
  47. pmc Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer
    F P Guengerich
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Environ Health Perspect 104:557-62. 1996
    ..A series of studies is presented to show the complexities encountered with a single chemical, aflatoxin B1 (AFB1). AFB1 is oxidized by human cytochrome P450 enzymes to several products...
  48. ncbi Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B(1)
    Patrick J Klein
    Department of Veterinary Sciences, and Graduate Program in Toxicology, Utah State University, Logan, UT 84322 4620, USA
    Comp Biochem Physiol C Toxicol Pharmacol 132:193-201. 2002
    ..Our data indicate that efficient activation may underlie the extreme sensitivity of young turkeys to the toxic effects of AFB(1)...
  49. ncbi Ochratoxin A reduces aflatoxin B1 induced DNA damage detected by the comet assay in Hep G2 cells
    L A Corcuera
    Department of Nutrition, Food Sciences, Physiology and Toxicology, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E 31008 Pamplona, Spain
    Food Chem Toxicol 49:2883-9. 2011
    Mycotoxins aflatoxin B1 (AFB1) and ochratoxin A (OTA) can be present together in food commodities. These food contaminants are considered to be genotoxins, acting by different mechanisms...
  50. ncbi Fecal and urinary excretion of aflatoxin B1 metabolites (AFQ1, AFM1 and AFB-N7-guanine) in young Chinese males
    Hannu Mykkanen
    Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Int J Cancer 115:879-84. 2005
    Our study was designed to assess the fecal and urinary excretion of 3 aflatoxin B1 (AFB1) metabolites, aflatoxins M1 (AFM1) and Q1 (AFQ1) and aflatoxin B1-N7-guanine (AFB-N7-guanine) that are produced by the predominant forms of ..
  51. ncbi Dietary butylated hydroxytoluene protects against aflatoxicosis in Turkeys
    Patrick J Klein
    Department of Veterinary Scieces and Graduate Program in Toxicology, Utah State University, Lagan, Utah 84322 4620, USA
    Toxicol Appl Pharmacol 182:11-9. 2002
    ..These results indicate that BHT counteracts many of the deleterious effects caused by AFB(1) and that this antioxidant may prove to be a viable feed additive for the reduction of aflatoxicosis in turkeys...
  52. pmc Bypass of aflatoxin B1 adducts by the Sulfolobus solfataricus DNA polymerase IV
    Surajit Banerjee
    Department of Chemistry, Center in Molecular Toxicology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States
    J Am Chem Soc 133:12556-68. 2011
    ..The insertion of dTTP yields a structure similar to that observed for the AFB(1)-N7-dG adduct. The differential accommodation of these AFB(1) adducts within the active site may, in part, modulate lesion bypass...
  53. ncbi Functional characterization of alpha-class glutathione s-transferases from the Turkey (meleagris gallopavo)
    Ji Eun Kim
    Graduate Toxicology Program, Department of Veterinary Sciences, School of Veterinary Medicine, Utah State University, Logan, Utah, 84322 4620
    Toxicol Sci 124:45-53. 2011
    ..The observation that recombinant tGSTAs detoxify AFBO, whereas their hepatic forms do not, implies that the hepatic forms of these enzymes are silenced by one or more regulatory mechanisms...
  54. ncbi Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract
    Xiao Yang He
    School of Public Health Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Int J Cancer 118:2665-71. 2006
    The worldwide human exposure to aflatoxin B1 (AFB1), particularly in developing countries, remains to be a serious public health concern...
  55. ncbi Hepatitis B virus X antigen and aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish
    Jeng Wei Lu
    Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan Department of Life Sciences, National Central University, Jhongli City, Taoyuan, Taiwan
    Acta Histochem 115:728-39. 2013
    b>Aflatoxin B1 (AFB1) and the hepatitis B virus X antigen (HBx) are linked to the formation of liver diseases and hepatocellular carcinoma (HCC)...
  56. pmc Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity in Caco-2 Cells
    S Gratz
    Department of Clinical Nutrition, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Appl Environ Microbiol 73:3958-64. 2007
    The probiotic Lactobacillus rhamnosus GG is able to bind the potent hepatocarcinogen aflatoxin B1 (AFB1) and thus potentially restrict its rapid absorption from the intestine...
  57. ncbi Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage
    Lalini Reddy
    Department of Biotechnology, Durban Institute of Technology, Durban 4000, South Africa
    Biol Chem 387:87-93. 2006
    b>Aflatoxin B1 (AFB1) is a fungal toxin that has been associated with primary hepatocellular carcinoma (HCC) in humans...
  58. ncbi Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1
    Landry K Kamdem
    Department of Clinical Pharmacology, Georg August University, Goettingen, Germany
    Chem Res Toxicol 19:577-86. 2006
    The hepatic carcinogen aflatoxin B1 (AFB1) is metabolized in the liver by at least four different P450s, all of which exhibit large interindividual differences in the expression levels...
  59. ncbi In vitro evaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol-induced cell damage
    Stefano Costa
    Department of Pharmacology, University of Bologna, Via Irnerio 48, Bologna 40126, Italy
    J Appl Toxicol 29:7-14. 2009
    ..Different mycotoxins were evaluated in two different cell lines on the basis of their specific toxicity: aflatoxin B1 (AFB1) on HepG2 cells and deoxynivalenol (DON) on U937 cells...
  60. pmc Testing an aflatoxin B1 gene signature in rat archival tissues
    B Alex Merrick
    Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Chem Res Toxicol 25:1132-44. 2012
    ..with eventual tumor development could be detected in archival liver, kidney, and lung of rats exposed to aflatoxin B1 (AFB1) for 90 days in feed at 1 ppm. These tissues originated from the same rats used in the microarray study...
  61. ncbi Key roles of vitamins A, C, and E in aflatoxin B1-induced oxidative stress
    Lokman Alpsoy
    Fatih University, Science and Art Faculty, Department of Biology, Buyukcekmece, Istanbul, Turkey
    Vitam Horm 86:287-305. 2011
    ..This chapter reviews the mechanism of AFB(1)-induced oxidative stress and focuses on the protective effects of vitamins A, C, and E on reducing this stress...
  62. ncbi Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells
    Umberto Bernabucci
    Department of Animal Science, University of Tuscia, via S C de Lellis, 01100 Viterbo, Italy
    Toxicol In Vitro 25:684-91. 2011
    ..These results demonstrate that, even though by different mechanisms, AFB(1) and FB(1) may induce cytotoxicity through an impairment of the oxidative status of PBMC...
  63. ncbi Chemoprevention of aflatoxin B1-induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural bioflavonoid of Garcinia kola seeds
    E O Farombi
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Eur J Cancer Prev 14:207-14. 2005
    The chemopreventive effects of kolaviron, a natural antioxidant bioflavonoid from the seeds of Garcinia kola, on aflatoxin B1 (AFB1)-induced genotoxicity and hepatic oxidative damage was investigated in rats...
  64. ncbi Polymorphism in xeroderma pigmentosum complementation group C codon 939 and aflatoxin B1-related hepatocellular carcinoma in the Guangxi population
    Xi Dai Long
    Department of Pathology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Hepatology 52:1301-9. 2010
    ..capacity, and this may be associated with the risk and outcome of hepatocellular carcinoma (HCC) related to aflatoxin B1 (AFB1) exposure...
  65. ncbi Screening of Argentine plant extracts: impact on growth parameters and aflatoxin B1 accumulation by Aspergillus section Flavi
    R Bluma
    Departamento de Microbiologia e Inmunologia, Facultad de Ciencias Exactas Físico Químicas y Naturales Universidad Nacional de Río Cuarto 5800, Ruta Nacional N0 36 Km 601, Rio Cuarto, Cordoba, Argentina
    Int J Food Microbiol 122:114-25. 2008
    ..Studies on percentage of germination, germ-tube elongation rate, growth rate, and aflatoxin B1 accumulation were carried out...
  66. ncbi Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Cancer Res 63:4594-601. 2003
    ..These results indicate that the comparison of results from human studies and the AFB(1)-susceptible mouse model may provide new insights into hepatocarcinogenesis...
  67. ncbi [Study on the detoxication gene gstM1-gstT1-null and susceptibility to aflatoxin B1 related hepatocellular carcinoma in Guangxi]
    Xi Dai Long
    Pathology Department, Guangxi Medical University, Naning 530021, China
    Zhonghua Liu Xing Bing Xue Za Zhi 26:777-81. 2005
    To study the association between susceptibility to aflatoxin B1 (AFB1)-related hepatocellular carcinoma(HCC) and the null genotypes of detoxication gene gstM1 and gstT1.
  68. ncbi Role of aflatoxin B1 as a risk for primary liver cancer in north Indian population
    Mohammad Asim
    Department of Medicine, Maulana Azad Medical College, University of Delhi, New Delhi, India
    Clin Biochem 44:1235-40. 2011
    The present study was designed to determine whether aflatoxin B1 (AFB1) exposure has any role to play in hepatocellular carcinoma (HCC) patients from northern India.
  69. pmc Urinary 15-F2t-isoprostane, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Carcinogenesis 29:971-6. 2008
    ..These results suggest that elevated levels of urinary 15-F(2t)-IsoP may be related to increasing level of aflatoxin exposure and are associated with an increased risk of HCC...
  70. ncbi A strip liposome immunoassay for aflatoxin B1
    J A A Ho
    University of Georgia Coastal Plain Experiment Station, Tifton 31793, USA
    Anal Chem 74:1493-6. 2002
    A technique has been developed for the preparation of aflatoxin B1 (AFB1)-tagged liposomes encapsulating a visible dye. These liposomes have several useful potential analytical applications, one of which is demonstrated...
  71. ncbi On the occurrence of aflatoxin M1 in milk and dairy products
    A Prandini
    Institute of Food Science and Nutrition, Catholic University of Piacenza, Agricultural Faculty, 29100 Piacenza, Via Emilia Parmense 84, Italy
    Food Chem Toxicol 47:984-91. 2009
    ..Kernel mechanical damage, grain cleaning practices and conservation temperature are also factors which need to be carefully controlled...
  72. ncbi Piezoelectric immunosensor with gold nanoparticles enhanced competitive immunoreaction technique for quantification of aflatoxin B1
    Xiaoyong Jin
    State Key Laboratory of Chemo Biosensing and Chemometrics, Chemistry and Chemical Engineering College, Hunan University, Changsha 410082, PR China
    Biosens Bioelectron 24:2580-5. 2009
    ..It is found that the as-renewed sensor could be reused at least 9 runs without obvious loss of sensing sensitivity...
  73. ncbi Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts
    Mosaad A Abdel-Wahhab
    Food Toxicology and Contaminants Department, National Research Center, Dokki, Cairo, Egypt
    J Appl Toxicol 26:229-38. 2006
    ..Cotreatment with AFB(1) and E1 or E2 resulted in an obvious improvement in all tested parameters. Noteworthy, E2 was more effective than E1 in the protection against AFB(1)-induced hepatotoxicity...
  74. ncbi Aflatoxin binders II: reduction of aflatoxin M1 in milk by sequestering agents of cows consuming aflatoxin in feed
    Duarte E Diaz
    Department of Animal Science, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695 7621, USA
    Mycopathologia 157:233-41. 2004
    Sequestering agents bind dietary aflatoxin B1 (AFB1) and reduce absorption from an animal's gastrointestinal tract...
  75. ncbi Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies
    Rozenn Josse
    Institut National de la Santé et de la Recherche Médicale U620, Universite de Rennes 1, Rennes, France
    Drug Metab Dispos 36:1111-8. 2008
    ....
  76. ncbi Cyanidin-3-O-beta-glucopyranoside, a natural free-radical scavenger against aflatoxin B1- and ochratoxin A-induced cell damage in a human hepatoma cell line (Hep G2) and a human colonic adenocarcinoma cell line (CaCo-2)
    M C Guerra
    Department of Pharmacology, University of Bologna, 40126 Bologna, Italy
    Br J Nutr 94:211-20. 2005
    Recent findings have suggested that oxidative damage might contribute to the cytotoxicity and carcinogenicity of aflatoxin B1 (AFB1)...
  77. ncbi Safety and efficacy evaluation of aqueous citric acid to degrade B-aflatoxins in maize
    A Méndez-Albores
    Unidad Queretaro, CINVESTAV IPN, Apartado Postal 1 798, C P 76230 Querétaro, Mexico
    Food Chem Toxicol 43:233-8. 2005
    Chemical inactivation of aflatoxin B1 (AFB1) and aflatoxin B2 (AFB2) in maize grain by means of 1N aqueous citric acid was confirmed by the AFLATEST immunoaffinity column method, high performance liquid chromatography (HPLC), and the Ames ..
  78. ncbi Fungal contamination and Aflatoxin B1 and Ochratoxin A in Lebanese wine-grapes and musts
    André El Khoury
    Centre d analyses et de Recherches, Faculte des Sciences, Université Saint Joseph, Beyrouth, Lebanon
    Food Chem Toxicol 46:2244-50. 2008
    ..isolated. All isolates were tested for the ability to produce the Ochratoxin A (OTA) and the Aflatoxin B1 (AFB1). A...
  79. pmc Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo
    Maxwell C K Leung
    Nicholas School of the Environment, Duke University, Durham, North Carolina 27708 0328, USA
    Toxicol Sci 118:444-53. 2010
    ..Our results highlight the importance of considering differences between xenobiotic metabolism in C. elegans and mammals when using this alternative model in pharmaceutical and toxicological research...
  80. ncbi Urinary 8-oxodeoxyguanosine, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Departments of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Carcinogenesis 28:995-9. 2007
    ..These results suggest that elevated levels of urinary 8-oxodG may be related to increasing level of aflatoxin exposure but may also indicate enhanced repair of oxidative DNA damage and therefore lower risk of HCC...
  81. ncbi Aflatoxin B1-induced TP53 mutational pattern in normal human cells using the FASAY (Functional Analysis of Separated Alleles in Yeast)
    Vincent Paget
    GRECAN EA1772 IFR 146 ICORE, Universite de Caen Basse Normandie et Centre Francois Baclesse, Av du Général Harris, 14076 Caen Cedex 05, France
    Mutat Res 656:55-61. 2008
    ..In hepatocellular carcinoma (HCC) related to exposure to aflatoxin B1, a specific G>T transversion in codon 249 is classically described as a hot spot...
  82. ncbi Red ginseng extract protects against aflatoxin B1 and fumonisins-induced hepatic pre-cancerous lesions in rats
    Mosaad A Abdel-Wahhab
    Food Toxicology and Contaminants Dept, National Research Center, Dokki, Cairo, Egypt
    Food Chem Toxicol 48:733-42. 2010
    ..effects of ginseng extract (GE) against pre-cancerous lesions in female Sprague-Dawley rats treated with aflatoxin B1 (AFB1) and fumonisin (FB)...
  83. ncbi High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York 10032, USA
    Mol Carcinog 35:85-92. 2002
    ..No association was found between methylation status and p53 status. These results suggest the hypothesis that exposure to environmental carcinogens may be involved in altered methylation of genes involved in cancer development...
  84. ncbi Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots
    J X Chen
    Department of Carcinogenesis, University of Texas, M D Anderson Cancer Center, Smithville 78957, USA
    Cancer Res 58:2070-5. 1998
    ..the p53 gene by a variety of carcinogens, including benzo(a)pyrene diol epoxide, benzo(g)chrysene diol epoxide, aflatoxin B1 8,9-epoxide, and N-acetoxy-2-acetylaminofluorene...
  85. ncbi Aflatoxin binders I: in vitro binding assay for aflatoxin B1 by several potential sequestering agents
    Duarte E Diaz
    Department of Animal Science, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695 7621, USA
    Mycopathologia 156:223-6. 2002
    ..bentonites, a calcium bentonite, and an esterified glucomannan were compared in a novel in vitro assay for aflatoxin B1 (AFB1) binding...
  86. ncbi Expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae reveals a functional role in aflatoxin B1 detoxification
    Edward J Kelly
    Department of Environmental Health and Center for Ecogenetics and Environmental Health, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 65:35-42. 2002
    The metabolism and genotoxicity of the carcinogenic mycotoxin, aflatoxin B1 (AFB), was studied in the lower eukaryotic yeast Saccharomyces cerevisiae...
  87. ncbi Molecular cloning and expression of a novel cytochrome p450 from turkey liver with aflatoxin b1 oxidizing activity
    Shirley S M Yip
    Graduate Program in Toxicology, Department of Veterinary Sciences, Utah State University, Logan, Utah 84322 4620, USA
    Chem Res Toxicol 19:30-7. 2006
    ..underlies the extreme sensitivity of poultry, specifically turkeys, to the toxic effects of the mycotoxin aflatoxin B1 (AFB1)...
  88. ncbi Preparation of gold-labeled antibody probe and its use in immunochromatography assay for detection of aflatoxin B1
    Sun Xiulan
    School of Food Science, Southern Yangtze University, 170, Huihe Road, Wuxi, Jiangsu 214036, PR China
    Int J Food Microbiol 99:185-94. 2005
    Preparation of an antibody-colloidal gold probe (conjugate) specific to aflatoxin B1 (AFB1) and its use in developing a rapid AFB1 diagnostic method was presented in this paper...
  89. ncbi Fumonisin B1 promotes aflatoxin B1 and N-methyl-N'-nitro-nitrosoguanidine-initiated liver tumors in rainbow trout
    D B Carlson
    Center for Molecular Toxicology, Penn State University, 226 Fenske Lab, University Park, Pennsylvania 16802, USA
    Toxicol Appl Pharmacol 172:29-36. 2001
    ..carcinogen, in the absence of an initiator; (ii) a promoter of liver tumors in fish initiated as fry with aflatoxin B1 (AFB1); and (iii) a promoter of liver, kidney, stomach, or swim bladder tumors in fish initiated as fry with N-..
  90. ncbi Antioxidant activity and inhibition of aflatoxin B1-, nifuroxazide-, and sodium azide-induced mutagenicity by extracts from Rhamnus alaternus L
    Rebai Ben Ammar
    Unité de Pharmacognosie Biologie Moléculaire 99 UR 07 03, Faculte de Pharmacie, Rue Avicenne, Monastir 5000, Tunisia
    Chem Biol Interact 174:1-10. 2008
    ..Our findings emphasize the potential of R. alaternus to prevent mutations and also its antioxidant effect...
  91. pmc Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors
    L I McLellan
    Department of Clinical Biochemistry, University of Edinburgh, Royal Infirmary, U K
    Biochem J 300:117-24. 1994
    Ingestion of aflatoxin B1 (AFB1) represents a major risk factor in the aetiology of human hepatocellular carcinoma...
  92. ncbi Butylated hydroxytoluene chemoprevention of aflatoxicosis - effects on aflatoxin B(1) bioavailability, hepatic DNA adduct formation, and biliary excretion
    J A Guarisco
    Department of Veterinary Sciences, Utah State University, Logan, UT 84322 4620, USA
    Food Chem Toxicol 46:3727-31. 2008
    ..Thus, the chemopreventive properties of BHT may also occur through a reduction in AFB(1) bioavailability in addition to inhibition of bioactivation...
  93. ncbi Comparison of the expression of beta-catenin in hepatocellular carcinoma in areas with high and low levels of exposure to aflatoxin B1
    Ke Chen Ban
    Immunology Unit, Department of Clinical Laboratory Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
    J Surg Oncol 86:157-63. 2004
    ..The aim of this study is to compare the expression of beta-catenin and p53 in hepatocellular carcinoma (HCC) from areas with exposure to high and low levels of aflatoxin B1 (AFB1).
  94. ncbi Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds
    Rozenn Josse
    UMR INSERM U991, Faculte des Sciences Pharmaceutiques et Biologiques, Rennes, France
    Toxicol Appl Pharmacol 258:176-87. 2012
    ..Primary human hepatocytes and differentiated HepaRG cells were exposed to aflatoxin B1 (AFB1) that induces DNA damage following enzyme-mediated bioactivation...
  95. ncbi Metabolic intervention of aflatoxin B1 toxicity by curcumin
    Sujatha Nayak
    Department of Biochemistry, University College of Science, Osmania University, Hyderabad, AP, India
    J Ethnopharmacol 127:641-4. 2010
    ..Curcumin, bioactive principle of turmeric (Curcuma longa Linn) is an important constituent of Indian traditional medicine. Turmeric has been known to possess several therapeutic properties...
  96. ncbi Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus parasiticus. A key enzyme in the aflatoxin B1 biosynthetic pathway
    J C Silva
    Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 272:804-13. 1997
    b>Aflatoxin B1 is a potent environmental carcinogen produced by certain strains of Aspergillus...
  97. ncbi Effect of pressure cooking on aflatoxin B1 in rice
    Je Won Park
    The Graduate School of Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    J Agric Food Chem 54:2431-5. 2006
    ..The average Korean daily intake of aflatoxin through the consumption of staple rice would fall to 0.15 ng/kg bw/day, which would not exceed the established tolerable daily intake (0.40 ng/kg bw/day)...
  98. ncbi Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis
    T S Hitchman
    Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Bioorg Chem 29:293-307. 2001
    ..Phylogenetic predictions and an analysis of GC-bias in AF and ST pathway genes compared with primary metabolic Aspergillus genes were used as a basis to propose a route for the evolution of the AF and ST clusters...
  99. ncbi Analysis of aflatoxin B1-lysine adduct in serum using isotope-dilution liquid chromatography/tandem mass spectrometry
    Leslie F McCoy
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Rapid Commun Mass Spectrom 19:2203-10. 2005
    A method for quantitative analysis of aflatoxin B1-lysine adduct (B1-Lys) in serum by liquid chromatography using tandem mass spectrometry (LC/MS/MS) is presented...
  100. ncbi [A study about the association of detoxication gene GSTM1 polymorphism and the susceptibility to aflatoxin B1-related hepatocellular carcinoma]
    Xi Dai Long
    Pathology Department, Guangxi Medical University, Nanning 530021, China
    Zhonghua Gan Zang Bing Za Zhi 13:668-70. 2005
    To investigate the association between susceptibility to aflatoxin B1(AFB1)-related hepatocellular carcinoma (HCC) and the polymorphism of detoxication gene GSTM1.
  101. ncbi Analysis of duplicate 24-hour diet samples for aflatoxin B1, aflatoxin M1 and ochratoxin A
    Eric A Sizoo
    Laboratory for Food and Residue Analyses, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Food Addit Contam 22:163-72. 2005
    ..nitrate and nitrite, and fatty acids, the duplicate diet study was concluded with analyses for aflatoxin M1, aflatoxin B1 and ochratoxin A...

Research Grants62

  1. SPECIES DIFFERENCE IN THE BIOTRANSFORMATION OF AFLATOXIN
    David Eaton; Fiscal Year: 2003
    ..One such model human carcinogen is aflatoxin B1. Aflatoxins are mycotoxins produced by the common fungal molds, Aspergillus flavus and Aspergillus parasiticus...
  2. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..multiple analyte profiles (MAPs);N-acetyl-p-Aminophenol(APAP);Nitrosodimethylamine;Anthraquinone;Aflatoxin B1;Ascorbic acid;l-tryptophan;Methlyeugenol;Senna;PolyBrominated diphenyl ether congeners;PBDE-47;Carcinogen and ..
  3. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..multiple analyte profiles (MAPs);N-acetyl-p-Aminophenol(APAP);Nitrosodimethylamine;Anthraquinone;Aflatoxin B1;Ascorbic acid;l-tryptophan;Methlyeugenol;Senna;PolyBrominated diphenyl ether congeners;PBDE-47;Carcinogen and ..
  4. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..by applicant): Hepatocellular carcinoma (HCC) has been correlated with specific p53 mutations and exposure to aflatoxin B1 (AFB1). Individual response to liver carcinogens shows great variability...
  5. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    ..Epidemiological studies have suggested that hepatitis B virus infection and dietary aflatoxin B1 (AFB1) are the two major etiological agents for human HCC...
  6. Genomic profiling of yeast resistance to AFB1, a P450-activated carcinogen
    MICHAEL THOMAS FASULLO; Fiscal Year: 2013
    ..successful in introducing human CYP1A2 and CYP1A1 into yeast and activating a variety of carcinogens, including aflatoxin B1 (AFB1), benzo[a]pyrene dihydrodiol (BaP-DHD), and heterocyclic amines (HA, food carcinogens)...
  7. The Environment as a Variable to Calibrate Mouse Models of Human Disease
    John M Essigmann; Fiscal Year: 2013
    ..As a tool, our work focuses on aflatoxin B1 (AFB1), an established risk factor for human hepatocellular carcinoma that strongly elevates risk in synergy ..
  8. Aflatoxin B1 hepatocarcinogenesis in the mGSTA3-/- mouse
    Stewart Sell; Fiscal Year: 2013
    ..HCC is a leading cause of cancer mortality worldwide, and dietary aflatoxin B1 (AFB1) exposure is a major risk factor...
  9. Biological Markers of Aflatoxin Exposure and Methylation
    Regina M Santella; Fiscal Year: 2013
    ..we demonstrated that, in conjunction with hepatitis B or C virus infection, elevated levels of biomarkers of aflatoxin B1 (AFB1) and polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress are associated with increased ..
  10. The RB pathway in liver cancer
    Julien Sage; Fiscal Year: 2013
    ..that cause HCC are well known and include infection by hepatitis B and C viruses (HBV and HCV), exposure to Aflatoxin B1, and excessive alcohol intake...
  11. Fungal Polyketide Synthases and Environmental Toxin Biosynthesis
    CRAIG ARTHUR TOWNSEND; Fiscal Year: 2013
    ..To the environmental carcinogen aflatoxin B1 can be added polyketide metabolites like T-2 toxin, zearalenone, fumonisin B, ochratoxin, patulin, citrinin and ..
  12. Impact of infection and inflammation on the toxicity of environmental chemicals
    CHARLES KNUTSON; Fiscal Year: 2013
    ..and infection on the toxicity of environmental chemicals, this project will study two liver toxins: arsenic and aflatoxin B1. Both chemicals are classified as human carcinogens by the International Agency for Research on Cancer (IARC)...
  13. DNA Adduct-Induced Mutagenesis
    Michael P Stone; Fiscal Year: 2013
    ..abstract_text> ..
  14. Allosteric DNAzyme sensors for practical detection of mycotoxins
    SCOTT SILVERMAN; Fiscal Year: 2007
    ..to the mycotoxin deoxynivalenol (DON) and other mycotoxins such as fumonisin B1, zearalenone (ZON), and aflatoxin B1; (2) Characterize and optimize the allosteric DNAzymes for toxin-sensing properties; and (3) Engineer ..
  15. Biomarkers for exposure to Stachybotrys
    Dorr Dearborn; Fiscal Year: 2007
    ..adducts and related urinary metabolites in parallel to that used for the epoxide derivative of the mycotoxin, aflatoxin B1. Hypothesis: Inhalation exposure of humans to strains of Stachybotrys chartarum producing satratoxin G will ..
  16. IMMUNOCHEMICAL STUDIES ON CARCINOGENIC MYCOTOXIN
    FUN CHU; Fiscal Year: 1990
    ..In addition, immunohistochemical techniques for monitoring the aflatoxin, ochratoxin, and T-2 toxin in the tissues of mice and rats that have ingested these mycotoxins have been developed. (HI) ..
  17. AFLATOXIN DNA ADDUCTS DETECTED BY MONOCLONAL ANTIBODIES
    John Groopman; Fiscal Year: 1992
    b>Aflatoxin B1 (AFB1) is one of the most potent liver carcinogens known for experimental animals, and a number of epidemiological studies have found strong positive associations between AFB1 exposure and human liver cancer...
  18. AFLATOXIN B1 AND NUCLEOLAR RNA SYNTHESIS
    Fu Li Yu; Fiscal Year: 1990
    Previous studies from others as well as from our own have established that aflatoxin B1 (AFB1) after activation either in vivo or in vitro strongly inhibits rat liver nuclear and nucleolar RNA synthesis...
  19. MECHANISMS OF INHIBITION OF CHEMICAL CARCINOGENESIS
    George Bailey; Fiscal Year: 1999
    ..CHL), a common food-grade chlorophyll derivative, has potent, dose-responsive blocking activity against aflatoxin B1 genotoxicity and liver cancer...
  20. BIOTOXICITY OF ACTIVATED OLEFINS
    Masato Koreeda; Fiscal Year: 1980
    ..g., vinyl chloride, trichloroethylene) and vinyl ethers (e.g., aflatoxin B1), 2) development of synthetic approaches to the proposed ultimate toxic and/or carcinogenic metabolites of ..
  21. Global Responses to Aflatoxin B1 & Alkylating Agents
    Leona Samson; Fiscal Year: 2006
    ..The model environmental agents to be studied are Aflatoxin B1 and its metabolites, plus a range of SNI and SN2 alkylating agents...
  22. SPECIES DIFFERENCES IN GLUTATHIONE-S-TRANSFERASE
    David Eaton; Fiscal Year: 1990
    ..b>Aflatoxin B1 (AFB) is a potent chemical carcinogen that occurs naturally in many grain products...
  23. PULMONARY TOXICOLOGY OF AFLATOXIN B1
    ROGER COULOMBE; Fiscal Year: 1990
    ....
  24. Zebrafish Carcinogenesis and Cytochrome P450 Expression
    DONALD BUHLER; Fiscal Year: 2004
    ..rainbow trout (Oncorhynchus mykiss), however, zebrafish are relatively resistant to certain carcinogens such as aflatoxin B1 (AFB1) and dibenzo[a,1]pyrene (DBP), thus reducing their utility as carcinogenesis models...
  25. DNA CONTENT OF DYSPLASTIC LESIONS IN HUMAN AND RAT LIVER
    Oscar Sudilovsky; Fiscal Year: 1991
    ..aneuploidy is caused by clastogenic changes due to the administration of methyl-N- nitros-urea/phenobarbital or aflatoxin B1/phenobarbital or by agents that produce abnormal or arrested mitotic spindles, such as diethylstilbestrol...
  26. CARCINOGEN TESTING: A MOUSE LYMPHOMA MUTATION SYSTEM
    Henry Bourne; Fiscal Year: 1980
    ..Beginning with aflatoxin B1 and benzo(a)pyrene, S49 cells will be incubated with carcinogens and, after a suitable expression time, cloned ..
  27. CHROMOSOMAL PROBES FOR MUTAGENESIS BY CARCINOGENS
    JOHN ESSIGMANN; Fiscal Year: 2007
    ..abstract_text> ..
  28. INITIATION--PROMOTION BIOASSAY IN MOUSE LIVER
    Michael Pereira; Fiscal Year: 1990
    ..tested and that phenobarbital promotion was required for activity by 5 of 7 carcinogens active in C3H (aflatoxin B1, 2-acetylaminofluorene, benzidine, DMBA, and beta-naph-thalamine)...
  29. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    Michael Fasullo; Fiscal Year: 2007
    ..by applicant): Hepatocellular carcinoma (HCC) has been correlated with specific p53 mutations and exposure to aflatoxin B1 (AFB1). Individual response to liver carcinogens shows great variability...
  30. Mechanism of cell death induced by aflatoxin B1
    Jessica Kosa; Fiscal Year: 2002
    DESCRIPTION: (Adapted from the Applicant?s Abstract): The goal of this study is to determine how aflatoxin B1 (AFB1) kills hepatocytes. First, I shall probe the sequence of biochemical events that leads to liver cell death...
  31. Modulation of Aflatoxin B1-induced hepatocarcinogenesis by RB loss
    Erik Knudsen; Fiscal Year: 2007
    ..such as chronic infection with hepatitis B virus or exposure to the DNA damaging hepatocarcinogen aflatoxin B1 (AFB1). Tumor development is largely driven by genetic lesions that subvert critical cellular pathways...
  32. EFFECT OF PERINATAL IMPRINTING ON ADULT CARCINOGENESIS
    T Campbell; Fiscal Year: 1980
    ..of these treatments on the intact animal will be studied by determining the disposition of two carcinogens, aflatoxin B1 and 3-methylcholanthrene...
  33. AFLATOXIN B1S ROLE IN HUMAN LIVER CANCER
    JONATHAN RHIM; Fiscal Year: 2000
    ..b>Aflatoxin B1 (AFB) is an environmental toxin implicated in human liver cancer...
  34. MUTATIONS IN HUMAN P53 SEQUENCES OF A P53 KNOCK-IN MOUSE
    Monica Hollstein; Fiscal Year: 2001
    ..whether a p53 hotspot mutation common in aflatoxin-associated human liver cancers occurs in liver tumors of aflatoxin B1-exposed, hepatitis B virus-transgenic/human p53 knock-in mice; 3) to generate mouse strains that harbor a ..
  35. GENETICS OF AFLATOXIN METABOLISM ROLE IN CARCINOGENESIS
    HIRA GURTOO; Fiscal Year: 1991
    ..The focus of the studies is on the initial steps of aflatoxin B1 (AFB1) carcinogenesis including: (a) activation and deactivation of AFB1 by various cytochromes P-450; (b) ..
  36. EFFECT OF NUTRITION ON CARCINOGEN AND TOXIN METABOLISM
    T Campbell; Fiscal Year: 1980
    The general objective of this research proposal will be to determine the role of nutrition on the metabolism of aflatoxin B1 (AFB1) and certain selected chemical carcinogens...
  37. POLYMORPHISM & GENETIC LINKAGE OF RAT CYTOCHROMES P-450
    FREDERICK WALZ; Fiscal Year: 1991
    ..b>Aflatoxin B1 (AFB1), steroids and an increasingly complex panel of substrates will be tested...
  38. CYANOHYDROXYBUTENE TOXICITY AND GLUTATHIONE
    Matthew Wallig; Fiscal Year: 1991
    ..by CHB- induced hepatic and pancreatic GSH accumulation against hepatotoxicity of acetaminophen, hepatic carcinogenicity of aflatoxin B1, and pancreatic carcinogenicity of azaserine, using short-term histochemical and histologic assays.
  39. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2009
    ..Trout are very sensitive to the hepatocarcinogenicity of aflatoxin B1 (AFB1), the only IARC human carcinogen where exposure is through the food supply...
  40. INTEGRATED ENVIRONMENTAL HEALTH MIDDLE SCHOOL PROJECT
    David Eaton; Fiscal Year: 2006
    ....
  41. Isothiocyanates as specific antagonists of human SXR
    David Eaton; Fiscal Year: 2009
    ..Finally, they could help to further elucidate the risks and benefits of sulforaphane, a potential dietary phytochemical that has been proposed as a safe 'nutraceutical'compound to reduce cancer risk. ..
  42. MARINE AND FRESHWATER BIOMEDICAL SCIENCES CENTER
    David Williams; Fiscal Year: 2006
    ..abstract_text> ..
  43. SIGNIFICANCE OF GENETIC VARIATION IN ESTROGEN METABOLISM
    David Eaton; Fiscal Year: 2001
    ..abstract_text> ..
  44. Colon and liver anticarcinogenicity by acetaminophen
    Gary Williams; Fiscal Year: 2004
    ..These experiments will provide the basis for future studies of prophylaxis against human carcinogens, such as aflatoxin B1. In addition, these experiments will provide support for the epidemiological observations of reduced cancer ..
  45. Chemopreventive Efficacy of Broccoli Sprouts in Humans
    Thomas Kensler; Fiscal Year: 2004
    ..abstract_text> ..
  46. Modulation of Oxidative Damage by Tea Polyphenols
    Jia Sheng Wang; Fiscal Year: 2002
    ..The results of this proposed study will help to understand the mechanisms of antioxidative role of tea polyphenols in modulating human hepatocarcinogenesis caused by hepatitis B/C viruses and aflatoxins. ..
  47. Protection by Induction of Ubiquitin-Proteasome Systems
    Thomas Kensler; Fiscal Year: 2005
    ....
  48. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2005
    ..Successful completion of these collective studies should provide better understanding of the ways in which human P450s catalyze oxidation of carcinogens and drugs and the significance of variations in these enzymes. ..
  49. HUMAN FETAL LIVER GST--HYDROXYNONENAL CONJUGATION
    Evan Gallagher; Fiscal Year: 2002
    ..In addition, this project has important implications in terms of the in utero effects of pro-oxidant drugs or chemicals to which pregnant women are exposed. ..
  50. ROLE OF NF-KB IN TGF-B1 INDUCED APOPTOSIS OF HEPATOCYTES
    Marcello Arsura; Fiscal Year: 2005
    ..Furthermore, these findings will provide important insights into the role of NF- kappaB/Rel factors in the control of apoptosis of normal and transformed hepatocytes of potential clinical relevance. ..
  51. Egypt Smoking Prevention Research Initiative
    Christopher Loffredo; Fiscal Year: 2006
    ..The establishment of the ESPRI and the professional development of Egyptian investigators and Research Associates will accelerate Egypt's efforts to become tobacco free. ..
  52. Gender Differences in Bladder Cancer Risk Factors
    Christopher A Loffredo; Fiscal Year: 2010
    ..squamous). The results of this study will help establish the best preventive measures for bladder cancer in men and women, by appropriately directing the resources of the public health sector for effective cancer control. ..
  53. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ....
  54. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  55. MALIGNANT COMPLICATIONS OF CHRONIC HCV
    Christopher Loffredo; Fiscal Year: 2009
    ..This set of aims and molecular epidemiology methods represents a novel approach to the study of the malignant complications of chronic HCV infection. ..
  56. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
    ..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..