vitamin b 12

Summary

Summary: A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues.

Top Publications

  1. pmc Transposable elements: targets for early nutritional effects on epigenetic gene regulation
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 23:5293-300. 2003
  2. ncbi Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes
    Dmitry A Rodionov
    State Scientific Center GosNIIGenetika, Moscow 113545, Russia
    J Biol Chem 278:41148-59. 2003
  3. doi Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway
    Marianne J Nielsen
    Department of Biomedicine, Aarhus University, Ole Worms Allé 3, Building 1170, 8000 Aarhus, Denmark
    Nat Rev Gastroenterol Hepatol 9:345-54. 2012
  4. ncbi Homocysteine and cardiovascular disease
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Annu Rev Med 49:31-62. 1998
  5. pmc A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
    N M van der Put
    Department of Pediatrics, University Hospital Nijmegen, Nijmegen, The Netherlands
    Am J Hum Genet 62:1044-51. 1998
  6. ncbi Algae acquire vitamin B12 through a symbiotic relationship with bacteria
    Martin T Croft
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK
    Nature 438:90-3. 2005
  7. pmc Regulation of the vitamin B12 metabolism and transport in bacteria by a conserved RNA structural element
    Alexey G Vitreschak
    Integrated Genomics Moscow, 117333, Russia
    RNA 9:1084-97. 2003
  8. ncbi Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin
    W A Bauman
    Department of Medicine, Mount Sinai School of Medicine, New York, USA
    Diabetes Care 23:1227-31. 2000
  9. doi Cancer incidence and mortality after treatment with folic acid and vitamin B12
    Marta Ebbing
    Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, Bergen, Norway 5021
    JAMA 302:2119-26. 2009
  10. pmc Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Am J Clin Nutr 94:348S-358S. 2011

Detail Information

Publications434 found, 100 shown here

  1. pmc Transposable elements: targets for early nutritional effects on epigenetic gene regulation
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 23:5293-300. 2003
    ..These findings suggest that dietary supplementation, long presumed to be purely beneficial, may have unintended deleterious influences on the establishment of epigenetic gene regulation in humans...
  2. ncbi Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes
    Dmitry A Rodionov
    State Scientific Center GosNIIGenetika, Moscow 113545, Russia
    J Biol Chem 278:41148-59. 2003
    ..Moreover, B12 regulons of various bacteria are thought to include enzymes from known B12-dependent or alternative pathways...
  3. doi Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway
    Marianne J Nielsen
    Department of Biomedicine, Aarhus University, Ole Worms Allé 3, Building 1170, 8000 Aarhus, Denmark
    Nat Rev Gastroenterol Hepatol 9:345-54. 2012
    ..This Review describes basic and clinical features of this multistep pathway with emphasis on gastrointestinal transport of B(12) and its importance in clinical medicine...
  4. ncbi Homocysteine and cardiovascular disease
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Annu Rev Med 49:31-62. 1998
    ..Supplementation with B-vitamins, in particular with folic acid, is an efficient, safe, and inexpensive means to reduce an elevated tHcy level. Studies are now in progress to establish whether such therapy will reduce cardiovascular risk...
  5. pmc A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
    N M van der Put
    Department of Pediatrics, University Hospital Nijmegen, Nijmegen, The Netherlands
    Am J Hum Genet 62:1044-51. 1998
    ....
  6. ncbi Algae acquire vitamin B12 through a symbiotic relationship with bacteria
    Martin T Croft
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK
    Nature 438:90-3. 2005
    ..The source of cobalamin seems to be bacteria, indicating an important and unsuspected symbiosis...
  7. pmc Regulation of the vitamin B12 metabolism and transport in bacteria by a conserved RNA structural element
    Alexey G Vitreschak
    Integrated Genomics Moscow, 117333, Russia
    RNA 9:1084-97. 2003
    ..These lineage-specific duplications of RNA regulatory elements seem to be a major evolutionary mechanism for expansion of the vitamin B(12) regulon...
  8. ncbi Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin
    W A Bauman
    Department of Medicine, Mount Sinai School of Medicine, New York, USA
    Diabetes Care 23:1227-31. 2000
    ..The objective of this study was to determine the magnitude and mechanism of the reduction in serum vitamin B12 after metformin administration...
  9. doi Cancer incidence and mortality after treatment with folic acid and vitamin B12
    Marta Ebbing
    Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, Bergen, Norway 5021
    JAMA 302:2119-26. 2009
    ..Recently, concern has been raised about the safety of folic acid, particularly in relation to cancer risk...
  10. pmc Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Am J Clin Nutr 94:348S-358S. 2011
    ..Much work remains to be done...
  11. pmc Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 18:4677-87. 2009
    ..40 x 10(-15)). Genome-wide significant loci were not identified for plasma folate. These data reveal new biological candidates and confirm prior candidate genes for plasma homocysteine, plasma vitamin B12 and plasma PLP...
  12. ncbi Microbial production of vitamin B12
    J H Martens
    Institute for Microbiology, Technical University Braunschweig, Germany
    Appl Microbiol Biotechnol 58:275-85. 2002
    ..Current strategies for the improvement of vitamin B12 production using modern biotechnological techniques are outlined...
  13. pmc Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy
    Daryl J Wile
    Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Diabetes Care 33:156-61. 2010
    ..We hypothesized that metformin exposure would be associated with lower Cbl levels, elevated Hcy and MMA levels, and more severe peripheral neuropathy...
  14. pmc Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood
    Y Ba
    School of Public Health, Zhengzhou University, Zhengzhou, China
    Eur J Clin Nutr 65:480-5. 2011
    ..The aim of the study is to investigate the relationship between folate, vitamin B(12) and methylation of the IGF2 gene in maternal and cord blood...
  15. ncbi Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer
    Shumin M Zhang
    Department of Epidemiology, Harvard School of Public Health, Division of Preventive Medicine, Boston, MA 02115, USA
    J Natl Cancer Inst 95:373-80. 2003
    ..However, data relating plasma folate levels to breast cancer risk are sparse. We investigated the association between plasma folate and other vitamins with breast cancer in a prospective, nested case-control study...
  16. ncbi Maternal methyl supplements increase offspring DNA methylation at Axin Fused
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, Texas 77030, USA
    Genesis 44:401-6. 2006
    ..Our results indicate that stochastic establishment of epigenotype at metastable epialleles is, in general, labile to methyl donor nutrition, and such influences are not limited to early embryonic development...
  17. pmc Common variants of FUT2 are associated with plasma vitamin B12 levels
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Program in Molecular and Genetic Epidemiology, Boston, Massachusetts 02115, USA
    Nat Genet 40:1160-2. 2008
    ..This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels...
  18. ncbi The biosynthesis of adenosylcobalamin (vitamin B12)
    Martin J Warren
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London, UK E1 4NS
    Nat Prod Rep 19:390-412. 2002
    ..This review covers some of the most important findings that have been made and provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl). 183 references are cited...
  19. doi New derivatives of vitamin B12 show preferential targeting of tumors
    Robert Waibel
    Center for Radiopharmaceutical Science, Paul Scherrer Institute, Villigen PSI, Switzerland
    Cancer Res 68:2904-11. 2008
    ..The low systemic distribution of radioactivity and the high tumor to blood ratio opens the possibility of a more successful clinical application of vitamin B12 for imaging or therapy...
  20. pmc Biomarkers of vitamin B-12 status in NHANES: a roundtable summary
    Elizabeth A Yetley
    Office of Dietary Supplements, National Institutes of Health, Bethesda, MD 20892 7517, USA
    Am J Clin Nutr 94:313S-321S. 2011
    ..Reliable measurement procedures are available, and National Institute of Standards and Technology reference materials are available or in development for serum vitamin B-12 and MMA...
  21. pmc Advances in standardization of laboratory measurement procedures: implications for measuring biomarkers of folate and vitamin B-12 status in NHANES
    Jay L Bock
    Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY, USA
    Am J Clin Nutr 94:332S-336S. 2011
    ..This article reviews some basic principles of metrology and describes their recent application to measurements of folate and vitamin B-12...
  22. pmc Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged > or =60 y in the United States
    Regan L Bailey
    Office of Dietary Supplements, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 92:383-9. 2010
    ..Unmetabolized serum folic acid (UMFA) has been detected in adults. Previous research indicates that high folic acid intakes may be associated with risk of cancer...
  23. pmc Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study
    C S Yajnik
    Diabetes Unit, KEM Hospital and Research Centre, Pune, Maharashtra, India
    Diabetologia 51:29-38. 2008
    ..We studied the association between maternal vitamin B12, folate and tHcy status during pregnancy, and offspring adiposity and insulin resistance at 6 years...
  24. ncbi Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort
    P F Jacques
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 73:613-21. 2001
    ..Established determinants of fasting total homocysteine (tHcy) concentration include folate and vitamin B-12 status, serum creatinine concentration, and renal function...
  25. ncbi Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians
    H Refsum
    Department of Pharmacology and the Locus for Homocysteine and Related Vitamins, University of Bergen, Norway
    Am J Clin Nutr 74:233-41. 2001
    ..In India, most people adhere to a vegetarian diet, which may lead to cobalamin deficiency...
  26. ncbi Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 87:734-43. 2008
    ..B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis...
  27. ncbi Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study
    Clara Gram Gjesdal
    Department of Public Helath and Primary Health Care, University of Bergen, Bergen, Norway
    J Bone Miner Res 22:747-56. 2007
    ..High levels of homocysteine and low levels of folate predicted fracture, whereas vitamin B12 and genotypes were not related to fracture risk. High homocysteine may be a modifiable risk factor for hip fracture...
  28. pmc Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization
    Yan Zhang
    Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588 0664, USA
    BMC Genomics 10:78. 2009
    ..Although a number of Ni and Co-dependent enzymes have been characterized, systematic evolutionary analyses of utilization of these metals are limited...
  29. ncbi Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial
    M G Wulffelé
    Department of Internal Medicine, Bethesda General Hospital, Hoogeveen, The Netherlands
    J Intern Med 254:455-63. 2003
    ..We investigated whether 16 weeks of treatment with metformin affects serum concentrations of homocysteine, folate and vitamin B12 in subjects with type 2 diabetes treated with insulin...
  30. ncbi The influence of erythrocyte folate and serum vitamin B12 status on birth weight
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Br J Nutr 93:593-9. 2005
    ..08, 0.42), P=0.005; n 145). These findings suggest that maternal folate status is an important determinant of infant birth weight. The combined effects of smoking and reduced RBC status on birth weight require further investigation...
  31. pmc The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism
    Steinar Hustad
    The Hormone Laboratory, Haukeland University Hospital, Bergen, Norway
    Am J Hum Genet 80:846-55. 2007
    ..Individuals with the TT genotype were particularly sensitive to the status of several B vitamins and might be candidates for personalized nutritional recommendations...
  32. ncbi Diagnosis and treatment of vitamin B12 deficiency--an update
    Anne Mette Hvas
    Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark
    Haematologica 91:1506-12. 2006
    ..Once the diagnosis of vitamin B12 deficiency has been confirmed efficient treatment can be ensured either by injections every 2-3 month or by a daily dose of 1 mg vitamin B12...
  33. ncbi Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study
    L J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 102:852-7. 2000
    ..Although numerous studies have assessed the impact of vitamin supplements on homocysteine, the effect of dietary patterns on homocysteine has not been well studied...
  34. ncbi High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status
    Ling Hao
    Institute of Reproductive and Child Health, Peking University, Beijing 100083, China, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Nutr 137:407-13. 2007
    ..Low plasma concentrations of folate, vitamins B-12 and B-6, older age, being male, and living in urban areas were all independently associated with elevated tHcy, with low folate as the strongest determinant...
  35. doi Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism
    Anvita Kale
    Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India
    Psychiatry Res 175:47-53. 2010
    ..These data may have important implications for the amelioration of psychopathology in schizophrenia...
  36. ncbi Vitamin B12 deficiency: a clinical and electrophysiological profile
    V Puri
    Department of Neurology, GB Pant Hospital, New Delhi, India
    Electromyogr Clin Neurophysiol 45:273-84. 2005
    ..The present study was conducted to evaluate the clinical and electrophysiological profile of vitamin B12 deficiency syndrome and whether a correlation exists between the disease process and the various electrophysiological parameters...
  37. doi Effect of homocysteine-lowering B vitamin treatment on angiographic progression of coronary artery disease: a Western Norway B Vitamin Intervention Trial (WENBIT) substudy
    Kjetil H Løland
    Institute of Medicine, University of Bergen, Bergen, Norway
    Am J Cardiol 105:1577-84. 2010
    ..In conclusion, vitamin B treatment showed no beneficial effect on the angiographic progression of coronary artery disease, and the post hoc analyses suggested that folic acid/vitamin B(12) treatment might promote more rapid progression...
  38. ncbi Common chelatase design in the branched tetrapyrrole pathways of heme and anaerobic cobalamin synthesis
    H L Schubert
    Department of Chemistry, University of York, U K
    Biochemistry 38:10660-9. 1999
    ..The structural similarity has implications for the understanding of the evolution of this branched biosynthetic pathway...
  39. ncbi Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies
    Bruno de Benoist
    Department of Nutrition for Health and Development, World Health Organization, 20 Avenue Appia, CH 1211, Geneva 27, Switzerland
    Food Nutr Bull 29:S238-44. 2008
  40. pmc Genomic DNA methylation changes in response to folic acid supplementation in a population-based intervention study among women of reproductive age
    Krista S Crider
    Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e28144. 2011
    ....
  41. pmc Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels
    Johan F B Arendt
    Department of Clinical Biochemistry, Aarhus University Hospital, Denmark
    PLoS ONE 7:e45979. 2012
    ..Measurement of serum cobalamin levels is routinely used to diagnose cobalamin deficiency. Surprisingly, approximately 15% of patients have high cobalamin levels and no consensus exists regarding the clinical implications...
  42. pmc Nitrosylcobalamin promotes cell death via S nitrosylation of Apo2L/TRAIL receptor DR4
    Zhuo Tang
    Center for Hematology and Oncology Molecular Therapeutics, Taussig Cancer Center, Cleveland, Ohio 44195, USA
    Mol Cell Biol 26:5588-94. 2006
    ..The C336A mutant also displayed blunted caspase-8 enzymatic activity following NO-Cbl treatment compared to the other mutants. Thus, DR4 residue C336 becomes S nitrosylated and promotes apoptosis following NO-Cbl treatment...
  43. ncbi Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin
    M Kristiansen
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Blood 96:405-9. 2000
    ..This now explains the malabsorption of Cbl and Cbl-dependent anemia in MGA1 patients with the FM1 mutation. (Blood. 2000;96:405-409)..
  44. pmc Sinorhizobium meliloti bluB is necessary for production of 5,6-dimethylbenzimidazole, the lower ligand of B12
    Gordon R O Campbell
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:4634-9. 2006
    ..Sequence comparison suggests that BluB is a member of the NADH/flavin mononucleotide (FMN)-dependent nitroreductase family, and we propose that it is involved in the conversion of FMN to DMB...
  45. doi Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls
    Fabio Coppede
    Faculty of Medicine, University of Pisa, Pisa, Italy
    Antioxid Redox Signal 17:195-204. 2012
    ..Moreover, we searched for correlation between each of the studied polymorphisms and available data on plasma homocysteine (Hcy), serum folate, and vitamin B12 values...
  46. ncbi The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings
    Wolfgang Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
    Curr Drug Metab 6:47-53. 2005
    ..Elevated MMA and normal holoTC in patients with renal insufficiency may not exclude vitamin B12 deficiency. HoloTC seems not to be a promising marker in predicting B12 status in renal patients...
  47. pmc Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra
    Carlos Enrique Orozco-Barrios
    Department of Physiology, Biophysics and Neuroscience, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional CINVESTAV, Mexico City, Mexico
    PLoS ONE 4:e8268. 2009
    ..To cause deprivation of vitamin B12, we have recently developed a cell model that produces decreased synthesis of S-adenosylmethionine by anchoring transcobalamin (TCII) to the reticulum through its fusion with Oleosin (OLEO)...
  48. pmc Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD 21250, USA
    Am J Hum Genet 84:477-82. 2009
    ..The ALPL gene likely influences the catabolism of vitamin B6 while FUT2 interferes with absorption of vitamin B12. These findings highlight mechanisms that affect vitamin B6, vitamin B12 and homocysteine serum levels...
  49. doi Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism
    David Coelho
    Division of Metabolism, Children s Research Center CRC, University Children s Hospital, Zurich, Switzerland
    Nat Genet 44:1152-5. 2012
    ..Furthermore, we show that mutations altering the putative ATPase domain of ABCD4 affect its function, suggesting that the ATPase activity of ABCD4 may be involved in intracellular processing of vitamin B12...
  50. doi Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials
    M Ebbing
    Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
    J Intern Med 268:367-82. 2010
    ....
  51. pmc Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
    JAMA 299:2027-36. 2008
    ..Observational data suggest benefits may be greater among women, yet women have been underrepresented in published randomized trials...
  52. doi Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population
    K K Sukla
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India
    Eur J Clin Nutr 66:111-8. 2012
    ..To assess the incidence of hyperhomocysteinemia and its correlation with the polymorphism in homocysteine (Hcy)-pathway genes and associated cofactors in the native populations of eastern India...
  53. ncbi Folate, vitamin B12, and homocysteine levels in South Asian women with growth-retarded fetuses
    Bo Lindblad
    Department of Public Health Sciences, Division of International Health IHCAR, Karolinska Institutet, Stockholm, Sweden
    Acta Obstet Gynecol Scand 84:1055-61. 2005
    ..To investigate whether intrauterine growth retardation (IUGR) and preterm delivery in a poor population of South Asia was associated with altered maternal and fetal levels of folate, vitamin B12, and homocysteine...
  54. pmc Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population
    Mohsin Yakub
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    PLoS ONE 7:e33222. 2012
    ....
  55. pmc Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase
    Vahe Bandarian
    Biophysics Research Division, University of Michigan, Ann Arbor, MI 48109 1055, USA
    Proc Natl Acad Sci U S A 100:8156-63. 2003
    ..These results suggest that the methylation state of the cobalamin will influence the distribution of conformers during turnover...
  56. ncbi The structural basis for molecular recognition by the vitamin B 12 RNA aptamer
    D Sussman
    Department of Biology and Center for the Molecular Biology of RNA, Sinsheimer Laboratories, University of California, Santa Cruz, California 95064, USA
    Nat Struct Biol 7:53-7. 2000
    ..The nature of the interactions that stabilize complex formation and the possible uncoupling of folding and binding for this RNA suggest a strong mechanistic similarity to typical protein-ligand complexes...
  57. pmc Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells
    Edward S Moreira
    Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA
    Free Radic Biol Med 51:876-83. 2011
    ..CNCbl also attenuated elevated O(2)(•-) levels after exposure of cells to a Cu/Zn-SOD inhibitor. Our data suggest that Cbl acts as an efficient intracellular O(2)(•-) scavenger...
  58. ncbi Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate reductase gene in Japanese
    Yuri Moriyama
    Public Health Institute of Kochi Prefecture, Marunouchi 2 4 1, 780 0850, Kochi, Japan
    Atherosclerosis 164:321-8. 2002
    ..These findings suggest that elevated homocysteine levels among Japanese with the homozygous genotype for the MTHFR gene mutation can be modified efficiently by dietary supplement of vitamin B12 as well as folate...
  59. doi Association of cognitive impairment with combinations of vitamin B₁₂-related parameters
    Dorte L Lildballe
    Department of Clinical Biochemistry, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Clin Chem 57:1436-43. 2011
    ....
  60. ncbi Domain alternation switches B(12)-dependent methionine synthase to the activation conformation
    Vahe Bandarian
    Biophysics Research Division and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 1055, USA
    Nat Struct Biol 9:53-6. 2002
    ....
  61. ncbi Signs of impaired cognitive function in adolescents with marginal cobalamin status
    M W Louwman
    Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, Netherlands
    Am J Clin Nutr 72:762-9. 2000
    ..38; 95% CI: -0.62, - 0.14). CONCLUSION: Our data suggest that cobalamin deficiency, in the absence of hematologic signs, may lead to impaired cognitive performance in adolescents...
  62. ncbi Trends in blood folate and vitamin B-12 concentrations in the United States, 1988 2004
    Christine M Pfeiffer
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Clin Nutr 86:718-27. 2007
    ..Monitoring the folate status of US population groups over time has been a public health priority for the past 2 decades, and the focus has been enhanced since the implementation of a folic acid fortification program in the mid-1990s...
  63. pmc Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility
    Ebba Nexo
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Am J Clin Nutr 94:359S-365S. 2011
    ..To date, holoTC has not been used for population-based assessments of vitamin B-12 status, but we suggest that holoTC is a better marker than total vitamin B-12 for such studies...
  64. pmc Overview of a roundtable on NHANES monitoring of biomarkers of folate and vitamin B-12 status: measurement procedure issues
    Elizabeth A Yetley
    Office of Dietary Supplements, National Institutes of Health, Bethesda, MD 20892 7517, USA
    Am J Clin Nutr 94:297S-302S. 2011
    ..The roundtable supported the continued use of the National Institute of Standards and Technology (NIST) reference materials in NHANES biomarker analyses and the further development of additional reference materials by the NIST...
  65. pmc High-Level folate production in fermented foods by the B12 producer Lactobacillus reuteri JCM1112
    Filipe Santos
    Kluyver Centre for Genomics of Industrial Fermentation, TI Food and Nutrition, and NIZO Food Research, Kernhemseweg 2, P O Box 20, 6710 BA Ede, The Netherlands
    Appl Environ Microbiol 74:3291-4. 2008
    ..We used metabolic engineering applying genetic and physiological approaches to improve this ratio and developed a generic and natural process that significantly increases folate production...
  66. pmc Folate and vitamin B-12 biomarkers in NHANES: history of their measurement and use
    Elizabeth A Yetley
    Office of Dietary Supplements, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Clin Nutr 94:322S-331S. 2011
    ..This review summarizes the history and use of folate- and vitamin B-12-related biomarkers beginning with NHANES I (1974-1975) through 2010...
  67. pmc Effect of homocysteine-lowering treatment with folic Acid and B vitamins on risk of type 2 diabetes in women: a randomized, controlled trial
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:1921-8. 2009
    ..We investigated whether homocysteine-lowering treatment by B vitamin supplementation prevents the risk of type 2 diabetes...
  68. pmc Lactobacillus reuteri DSM 20016 produces cobalamin-dependent diol dehydratase in metabolosomes and metabolizes 1,2-propanediol by disproportionation
    Dinesh Diraviam Sriramulu
    Department of Microbiology, University College Cork, Cork, Ireland
    J Bacteriol 190:4559-67. 2008
    ..reuteri. The metabolosome-associated diol dehydratase we describe is the only candidate glycerol dehydratase present on inspection of the L. reuteri F275 genome sequence...
  69. ncbi Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians
    S Muthayya
    Division of Nutrition, Institute of Population Health and Clinical Research, St John s National Academy of Health Sciences, Bangalore, India
    Eur J Clin Nutr 60:791-801. 2006
    ..To assess the maternal sociodemographic, anthropometric, dietary and micronutrient status in apparently healthy pregnant women in order to determine their associations with intrauterine growth retardation (IUGR)...
  70. ncbi Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years
    C Hallert
    Coeliac Centre, Faculty of Health Sciences, Linkoping University, Sweden
    Aliment Pharmacol Ther 16:1333-9. 2002
    ..Patients with coeliac disease are advised to keep to a lifelong gluten-free diet to remain well. Uncertainty still exists as to whether this gives a nutritionally balanced diet...
  71. doi An update on cobalamin deficiency in adults
    N Dali-Youcef
    Service de Medecine Interne, diabète et maladies métaboliques, clinique médicale B, Hôpital Civil Hôpitaux Universitaires de Strasbourg, 1 Porte de l Hôpital, 67091 Strasbourg Cedex, France
    QJM 102:17-28. 2009
    ..Management of cobalamin deficiency with cobalamin injections is currently well codified, but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption...
  72. pmc Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria)
    Ralph Gräsbeck
    Biochemistry Unit, Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, FI 00290 Helsinki, Finland
    Orphanet J Rare Dis 1:17. 2006
    ..In diagnosing this disease, it is important to be aware that cobalamin deficiency affects enterocyte function; therefore, all tests suggesting general and cobalamin malabsorption should be repeated after abolishment of the deficiency...
  73. ncbi Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations
    R A M Dhonukshe-Rutten
    Department of Human Nutrition, Wageningen University, Wageningen, Netherlands
    Eur J Clin Nutr 63:18-30. 2009
    ..The objectives are to give an overview of the actual intake and status of folate and vitamin B12 in general populations in Europe, and to evaluate these in view of the current vitamin recommendations and the homocysteine concentration...
  74. pmc Vitamin B12 (cobalamin) deficiency in elderly patients
    Emmanuel Andres
    Department of Internal Medicine, Medical Clinic B, Strasbourg University Hospitals, Strasbourg, France
    CMAJ 171:251-9. 2004
    ..We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency...
  75. pmc Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline
    Christine C Tangney
    Department of Clinical Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 72:361-7. 2009
    ....
  76. ncbi Vitamin B12 and folate deficiency in later life
    Robert Clarke
    Clinical Trial Service Unit Division of Clinical Geratology University Department of Pharmacology, University of Oxford, Oxford, UK
    Age Ageing 33:34-41. 2004
    ..to examine the prevalence of vitamin B12 deficiency and folate deficiency in later life in representative samples of the elderly population in the United Kingdom...
  77. pmc Effects of vitamin B12 and folate deficiency on brain development in children
    Maureen M Black
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Food Nutr Bull 29:S126-31. 2008
    ....
  78. doi Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and meta-regression
    Roger C M Ho
    Department of Psychological Medicine, Yong Loo Lin School of Medicine, Singapore
    Am J Geriatr Psychiatry 19:607-17. 2011
    ..It remains unclear whether the findings can be generalized across studies...
  79. ncbi Vitamin B12, folic acid, and the nervous system
    Edward Reynolds
    Institute of Epileptology, King s College, Denmark Hill Campus, Cutcombe Road, London, SE5 6PJ, UK
    Lancet Neurol 5:949-60. 2006
    ..Folic acid and vitamin B12 may have roles in the prevention of disorders of CNS development, mood disorders, and dementias, including Alzheimer's disease and vascular dementia in elderly people...
  80. ncbi Cobalamin-dependent methionine synthase
    R V Banerjee
    Biophysics Research Division, University of Michigan, Ann Arbor 48109
    FASEB J 4:1450-9. 1990
    ..The review emphasizes the mechanistic information that will be needed in order to design rational inhibitors of the enzyme...
  81. pmc A distinct mechanism for the ABC transporter BtuCD-BtuF revealed by the dynamics of complex formation
    Oded Lewinson
    Division of Chemistry and Chemical Engineering, Pasadena, California, USA
    Nat Struct Mol Biol 17:332-8. 2010
    ....
  82. doi How common is vitamin B-12 deficiency?
    Lindsay H Allen
    US Department of Agriculture, ARS Western Human Nutrition Research Center, University of California, Davis, Davis, CA 95616, USA
    Am J Clin Nutr 89:693S-6S. 2009
    ..However, intervention studies are still needed to assess efficacy and functional benefits of increasing intake of the amounts likely to be consumed in flour, including in elderly persons with varying degrees of gastric atrophy...
  83. pmc Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children
    Vidya Bhate
    Kamalnayan Bajaj Diabetology Research Center, Pune, India
    Food Nutr Bull 29:249-54. 2008
    ..We have shown that maternal vitamin B12 status affects adiposity and insulin resistance in the child. Vitamin B12 is important for brain development and function...
  84. ncbi Cobalamin (coenzyme B12): synthesis and biological significance
    J R Roth
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Annu Rev Microbiol 50:137-81. 1996
    ..but not E. coli, have acquired by horizontal transfer the ability to synthesize B12 and degrade propanediol. The acquired ability to degrade propanediol provides the selective force that maintains B12 synthesis in this group...
  85. pmc Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model
    M A Hofmann
    College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P and S 17 501, New York, NY 10032, USA
    J Clin Invest 107:675-83. 2001
    ..These findings implicate HHcy in atherosclerotic plaque progression and stability, and they suggest that dietary enrichment in vitamins essential for the metabolism of HC may impart protective effects in the vasculature...
  86. pmc TonB-dependent transporters: regulation, structure, and function
    Nicholas Noinaj
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 64:43-60. 2010
    ..However, the transport mechanism is still unclear. In this review, we summarize recent progress in understanding regulation, structure, and function in TBDTs and questions remaining to be answered...
  87. ncbi Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial
    Yoshihiro Sato
    Department of Neurology, Mitate Hospital, Tagawa, Japan
    JAMA 293:1082-8. 2005
    ..Hyperhomocysteinemia is a risk factor for both ischemic stroke and osteoporotic fractures in elderly men and women. Treatment with folate and mecobalamin (vitamin B12) may improve hyperhomocysteinemia...
  88. ncbi Plasma total homocysteine, folate, and vitamin B12 status in Korean adults
    Hyeon Sook Lim
    Department of Food and Nutrition, Chonnam National University, Yongbong Dong, Buk gu Gwangju, 500 757, Korea
    J Nutr Sci Vitaminol (Tokyo) 48:290-7. 2002
    ..Our results indicate that male adults may be in worse condition for cardiovascular disease (CVD) than females. And improving folate and vitamin B12 status may reduce plasma tHcy level, which may be more important in males...
  89. ncbi Folate, vitamin B12, and neuropsychiatric disorders
    T Bottiglieri
    Kimberly H Courtwright and Joseph W Summers Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Texas, USA
    Nutr Rev 54:382-90. 1996
    ..In addition, the neurotoxic effects of homocysteine may also play a role in the neurologic and psychiatric disturbances that are associated with folate and vitamin B12 deficiency...
  90. pmc An ABC-type cobalt transport system is essential for growth of Sinorhizobium meliloti at trace metal concentrations
    Jiujun Cheng
    Center for Environmental Genomics, Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Bacteriol 193:4405-16. 2011
    ..In symbiosis, the alternate system(s) appeared to mediate cobalt transport into bacteroid cells, as low cbtJKL expression was detected in bacteroids and cbtJKL mutants formed N(2)-fixing nodules on alfalfa...
  91. doi Methionine, homocysteine, one carbon metabolism and fetal growth
    Satish C Kalhan
    Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Rev Endocr Metab Disord 13:109-19. 2012
    ..These unique changes in methionine and one carbon metabolism in response to physiological, nutritional and hormonal influences make these processes critical for cellular and organ function and growth...
  92. pmc Role of homocysteine in metR-mediated activation of the metE and metH genes in Salmonella typhimurium and Escherichia coli
    M L Urbanowski
    Department of Microbiology, University of Iowa, Iowa City 52242
    J Bacteriol 171:3277-81. 1989
    ..In contrast, homocysteine plays an inhibitory role in the metR-mediated activation of the metH gene, decreasing expression of a metH-lacZ gene fusion threefold...
  93. ncbi Cobalamin-independent methionine synthase from Escherichia coli: a zinc metalloenzyme
    J C Gonzalez
    Biophysics Research Division, University of Michigan, Ann Arbor 48109 1055, USA
    Biochemistry 35:12228-34. 1996
    ..A possible model for zinc-dependent activation of homocysteine by MetE is presented...
  94. ncbi Low vitamin B-12 status and risk of cognitive decline in older adults
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 86:1384-91. 2007
    ..Elevated total homocysteine (tHcy) concentrations have been associated with cognitive impairment, but it is unclear whether low vitamin B-12 or folate status is responsible for cognitive decline...
  95. ncbi High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study
    Katherine L Tucker
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 82:627-35. 2005
    ..It is not clear whether the observed associations between homocysteine and cognitive measures are causal or whether they are due to homocysteine, to independent actions of the B vitamins, or to both...
  96. ncbi Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations
    Lynn B Bailey
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    J Nutr 133:3748S-3753S. 2003
    ..The negative effects of low intakes of the methyl-related nutrients with high intakes of alcohol are additive, therefore changes in overall dietary patterns to ensure the consumption of a protective high methyl diet are recommended...
  97. doi Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study
    Anna C Verkleij-Hagoort
    Department of Obstetrics, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Mol Genet Metab 94:112-9. 2008
    ..The future enlargement of our sample size might demonstrate significant associations...
  98. pmc Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids
    Suzana Savvi
    Molecular Mycobacteriology Research Unit, University of the Witwatersrand and National Health Laboratory Service, P O Box 1038, Johannesburg 2000, South Africa
    J Bacteriol 190:3886-95. 2008
    ..tuberculosis in mice...
  99. ncbi Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study
    J B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 24:1403-10. 2001
    ..We examined relationships between homocysteine levels and features of insulin resistance syndrome (IRS)...
  100. ncbi B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegans
    D Majchrzak
    Department of Nutritional Sciences, University of Vienna, Vienna, Austria
    Ann Nutr Metab 50:485-91. 2006
    ..However, a vegetarian diet may be deficient in some nutrients. Exclusion of animal products in vegetarian diets may affect the status of certain B-vitamins, and further cause the rise of plasma homocysteine concentration...
  101. doi Relative and biomarker-based validity of a food frequency questionnaire that measures the intakes of vitamin B(12), folate, iron, and zinc in young women
    Flavia Fayet
    Discipline of Nutrition and Metabolism, School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    Nutr Res 31:14-20. 2011
    ..37, P < .01) and vitamin B(12) (r = 0.27, P < .01). The electronic FFQ developed in the present study is a relatively valid tool that was able to adequately assess and rank individuals according to their nutrient intakes...

Research Grants64

  1. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ....
  2. SPEAKER TRAVEL AND SCIENTIFIC SESSION SUPPORT FOR THE TERATOLOGY SOCIETY 50TH
    Christina Chambers; Fiscal Year: 2011
    ..Add Optional Project Narrative File Delete Optional Project Narrative File View Optional Project Narrative File !"#! ..
  3. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..Given a rapidly aging population, the study of the therapeutic potential of vitamin B12 is highly relevant since B12 deficiency is increasingly common, especially amongst the elderly. ..
  4. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
    ..abstract_text> ..
  5. MECHANISM AND CONTROL OF UREA BIOSYNTHESIS
    Frank M Raushel; Fiscal Year: 2011
    ..These studies may lead to the development of new antibiotics in the defense of bacterial infections. ..
  6. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..abstract_text> ..
  7. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri H Beaty; Fiscal Year: 2013
    ....
  8. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2013
    ....
  9. Antenatal Dietary Supplementation is a Risk Factor for Infant Atopy Through Epige
    DAVID ALBERT SCHWARTZ; Fiscal Year: 2010
    ..Our research team proposes to determine if such concerns about methyl donor supplementation are justified and pose a real threat in expectant mothers already at risk for transmitting an atopic genetic predisposition to their infants. ..
  10. Maternal methyl diet and epigenetic imprint in offspring mammary carcinogenesis
    CHUNG SUN PARK; Fiscal Year: 2012
    ..Data from the study may have clinical impacts for developing prenatal dietary strategies for reduction of breast cancer risk in offspring. ..
  11. Risk Factors for Craniosynostosis
    Suzan L Carmichael; Fiscal Year: 2010
    ..This research will fill an important data gap by launching forward our knowledge regarding etiologies of CS and providing direction for the next generation of studies of CS. ..
  12. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia M Ulrich; Fiscal Year: 2012
    ..Through this research, we will learn more about how to prevent colorectal cancer and about possible public health recommendations based on genetic characteristics. ..
  13. Crystalline hydroxocobalamin and methemoglobin as a treatment of H2S intoxication
    PHILIPPE A HAOUZI; Fiscal Year: 2013
    ..Intranasal or intramuscular administration of Vitamin B12 represents an interesting alternative to intravenous infusion that could be implemented by non-professional rescuers to a large number of patients. ..
  14. Prevalence of environmental and genetic risk factors for gastric cancer in a popu
    LOVELL ALLAN JONES; Fiscal Year: 2011
    ..Findings from our study may also serve to reduce existent GC health disparities worldwide and in the U.S. ..
  15. Corrinoid Response of the Human Gut Microbiota
    Andrew L Goodman; Fiscal Year: 2013
    ..abstract_text> ..
  16. The Role of Maternal Nutrition in the Teratogenesis of Alcohol in Humans
    Robert Colin Carter; Fiscal Year: 2013
    ....
  17. Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats
    Gerry R Boss; Fiscal Year: 2012
    ..Moreover, resources will be saved because most of the pre-clinical toxicology and pharmacokinetic studies, and the Phase I Clinical Trials, will have already been done. ..
  18. Optimizing Maternal-Child Health in Kenya
    ASOK ANTONY; Fiscal Year: 2013
    ..Such studies are a necessary prelude to a larger community-based longitudinal project via a NIH R01 format. 1 ..
  19. Stable isotope evaluation of the methionine cycle in undernourished pregnancy
    Peter W Nathanielsz; Fiscal Year: 2013
    ..Information will translate to human pregnancy aiding diagnostic, preventative and therapeutic strategies. B12 has been ignored in comparison to folic acid. ..
  20. MOLECULAR GENETICS OF RHIZOBIUM NODULATION PLASMIDS
    Graham C Walker; Fiscal Year: 2013
    ..The project has offered novel insights into the biosynthesis of B12, a critically important vitamin for human health, and will continue to explore the role of vitamin B12 in biology. ..
  21. Novel Risk Factors For Hypertension
    John P Forman; Fiscal Year: 2010
    ..Sc.D., a well-known epidemiologist with an interest in HTN. This project proposal will provide the foundation for the candidate's future career as an independent and successful clinical scientist in HTN research. (End of Abstract) ..
  22. Integration of S-adenosylmethionine Metabolism with Epigenetics and Cell Cycle
    Stacey Borrego; Fiscal Year: 2013
    ..My thesis proposal will only begin to address nutrient imbalance as a factor of epigenetic changes. However, I will develop tools to allow others to expand research on the interaction between nutrients and epigenetics. ..
  23. Increasing Animal Foods in Diets of HIV-Infected Kenyan Women and Their Children
    Judith A Ernst; Fiscal Year: 2011
    ..Methodologies (BIA and anthropometry) will be validated with isotope dilution (2H2O) in a sub-sample of the enrolled drug nave HIV-infected Kenyan women. ..
  24. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2009
    ..The proposed application should help to answer important scientific questions on the dietary prevention of a debilitating disease that affects a large number of older persons. ..
  25. Testing Oral Delivery of the Appetite Suppressing Peptide PYY3-36 Through the Vit
    Robert P Doyle; Fiscal Year: 2013
    ..Biochemical effects triggered by oral administration in addition to feeding will be Lee adiposity index, and c-Fos. Secondary outcomes include PYY, insulin and glucose from serum samples. ..
  26. MOLECULAR MECHANISMS OF MEMBRANE TRANSPORT
    David S Cafiso; Fiscal Year: 2012
    ..Knowledge of these transport mechanisms will assist with the development of new antibiotics that can inhibit bacterial growth. ..
  27. Perioperative pharmacogenetics: Nitrous oxide and anesthetic outcomes
    Peter Nagele; Fiscal Year: 2013
    ..Thus, this research might serve as important evidence to assess the safety of nitrous oxide in high-risk patients. ..
  28. Homeostatic Regulation of Folate Metabolism
    Patrick J Stover; Fiscal Year: 2013
    ....
  29. Folic Acid Vitamin B12 and One Carbon Metabolism
    CHARLES HOPKINSON HALSTED; Fiscal Year: 2010
    ....
  30. Folic Acid, B-Vitamins and AMD: Blood and Diet-based Studies
    William G Christen; Fiscal Year: 2012
    ....
  31. Development of a Field-Deployable Device to Rapidly Measure Blood Cyanide Levels
    Hans Boehringer; Fiscal Year: 2011
    ..Successful accomplishment of the goals of this project will be the basis for the development of a test to detect and measure cyanide blood poisoning which will allow healthcare providers to treat patients quickly and effectively. ..
  32. Pre-clinical and Clinical Studies of Cobinamide, a New Cyanide Detoxifying Agent
    Gerry R Boss; Fiscal Year: 2013
    ..We propose to conduct Phase I clinical trials of a new cyanide antidote that could be given rapidly by intramuscular injection to many cyanide-exposed victims. ..
  33. Epidemiology of Prenatal Factors and Adult Psychopathology
    ALAN STEWART BROWN; Fiscal Year: 2012
    ....
  34. B12 Trafficking and Birth Defects
    RUMA V BANERJEE; Fiscal Year: 2013
    ....
  35. Translocation through TonB-dependent transporters
    Karen Jakes; Fiscal Year: 2013
    ..Better understanding the mechanisms that mobilize that uptake will allow design of means to inhibit that essential process. ..
  36. Peripheral nerve decline: an underappreciated cause of injurious falls
    Elsa S Strotmeyer; Fiscal Year: 2013
    ..The ultimate goal is to determine if peripheral nerve testing identifies older adults at higher risk for fall injuries, fractures and deth that may benefit from preventive measures for nerve decline or clinical outcomes. ..
  37. TAS::75 0849::TAS PURIFICATION, REFORMULATION AND PHARMACOKINETICS OF NITROSYLCO
    Joseph Bauer; Fiscal Year: 2010
    ..Purity (98%) of nitrosylcobalamin as determined by HPLC analysis. ..
  38. B12 Nutrition in the Aged
    Sally Stabler; Fiscal Year: 2007
    ..This paradox is explained because many seniors continue to have undiagnosed and untreated vitamin B 12 deficiency as shown by elevated serum methylmalonic acid concentrations...
  39. Single Molecule Optically Resonant NanoTweezers for the study of Intracellular Me
    David Erickson; Fiscal Year: 2013
    ..When applied to intracellular metal transport these capabilities can speed up the process for discovering how metalochaperones respond to different environmental conditions and ultimately what leads to the pathologies listed above. ..
  40. A finger-prick medical diagnostic for vitamin B12 malabsorption: An early interv
    STEPHEN DUEKER; Fiscal Year: 2006
    ..The work is significant as it would lead to a needed convenient diagnostic test for the clinical B12 malabsorption that can be employed in the clinic or in research settings. [unreadable] [unreadable] [unreadable]..
  41. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
    ..The proposed study is a cost-effective approach to determining whether a safe and inexpensive nutritional intervention substantially reduces the risk of fracture and to understanding the mechanism of this effect. ..
  42. In Vivo Cellular and Molecular Imaging Centers (ICMICs)
    David R Vera; Fiscal Year: 2012
    ..The Institutional support is significant. We have been provided prime space in the cancer center, all rodent imaging equipment are located in the cancer center adjacent to the vivarium, and key personnel. ..
  43. Control of gene expression by RNA conformational change during transcription
    George A Perdrizet; Fiscal Year: 2013
    ..Riboswitches are widespread genetic control elements. Second, the proposal will lay a general conceptual framework for the understanding of RNA conformational change during transcription. ..
  44. GORDON RESEARCH CONFERENCE ON PYRROLES
    SAMUEL BEALE; Fiscal Year: 1990
    ..Because of the breadth of coverage, the conference is considered by many of the participants to be the most important conference attended...
  45. LOCALIZED VITAMIN DEFICIENCIES AND RISK FOR LUNG CANCER
    Chandrika Piyathilake; Fiscal Year: 2001
    ..These activities, along with advanced studies of epidemiology and statistical analysis and experience in teaching, will provide the expertise needed for a career as a successful, independent investigator. ..
  46. A finger-prick medical diagnostic for vitamin B12 malabsorption - An early interv
    STEPHEN DUEKER; Fiscal Year: 2009
    ..The work is significant as it would lead to a needed convenient diagnostic test for B12 malabsorption that can be employed in the clinic or in research settings. ..
  47. Biosynthesis and Physiology of Vitamin B12 in Prokaryotes
    MICHIKO TAGA; Fiscal Year: 2009
    ..Together, these studies will contribute to the overall understanding of B12 biosynthesis and the function of B12 in bacteria-host interactions. ..
  48. STRUCTURE & FUNCTION OF B12 BINDING PROTEINS
    Robert Allen; Fiscal Year: 1993
    ....
  49. INDIANAPOLIS-IBADAN DEMENTIA PROJECT
    Kathleen S Hall; Fiscal Year: 2010
    ..Specific Aim 4: To examine the interaction between indices of social involvement and their change over time with the risk of cognitive decline in the African Americans and the Yoruba. ..
  50. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
  51. ADVANCED EPR STUDIES OF B12 DEPENDENT ENZYMES
    GARY GERFEN; Fiscal Year: 2005
    ..This "enzyme activation" of the cobalt-carbon bond j is a requirement for adenosylcobalamin-dependent catalysis. ..
  52. GENETIC ANALYSIS OF MG-TETRAPYRROLE BIOSYNTHESIS
    Carl Bauer; Fiscal Year: 2005
    ..It should also not be overlooked that tetrapyrrole driven photosynthesis is the primary route of capturing and supplying energy to living cells and, consequently, it is the most important source of energy in our technological world. ..
  53. Rapid, Inexpensive Microchip Assay for Homocysteine
    Dale Willard; Fiscal Year: 2009
    ..This is because devices like ours offer cheaper testing, closer to the patient, reduction in healthcare costs, and enhancements the physician-patient dialog and thus improving care. ..
  54. TREATMENT OF AIDS VACUOLAR MYELOPATHY WITH METHIONINE
    Alessandro DiRocco; Fiscal Year: 2002
    ..We request to complete the clinical trial and the metabolic observations of the study. ..
  55. Structural Characterizations of Transient and Heterogeneous Protein Complexes
    Nozomi Ando; Fiscal Year: 2013
    ..This work will be complemented by crystallography, spectroscopy, and analytical ultracentrifugation. ..
  56. EARLY URINE B12 DEFICIENCY DETECTION IN ELDERLY
    ERIC NORMAN; Fiscal Year: 1990
    ....
  57. TRIAL OF ANTIOXIDANT THERAPY OF CVD IN WOMEN
    JoAnn Manson; Fiscal Year: 2005
    ..With the gaps in knowledge this study is intended to address and the certain intense interest in its findings by the medical, lay, and regulatory communities, the proposed extension of this trial in women is both important and timely. ..
  58. STRUCTURAL BASIS OF VITAMIN B12 (COBALAMIN) DEFICIENCY
    Heidi Schubert; Fiscal Year: 2002
    ..3) Produce a model of intrinsic factor (IF), haptocorrin and transcobalamin I (TCI) based on the high amino acid sequence identity with TCII. ..
  59. TIME RESOLVED STUDIES OF B12 ENZYMES AN COENZYMES
    ROSEANNE SENSION; Fiscal Year: 2000
    ..In addition the role of the axial histidine ligand supplied by the protein will be probed by using a series of mutations to remove/replace this histidine and to alter the amino acid residues hydrogen bonded to the histidine. ..
  60. B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAIL
    HOWARD HODIS; Fiscal Year: 2004
    ..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
  61. Vascular Biochemistry of Vitamin B12
    DONALD JACOBSEN; Fiscal Year: 2006
    ..abstract_text> ..
  62. NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM
    Kenneth Hensley; Fiscal Year: 2005
    ..abstract_text> ..
  63. 2009 Vitamin B12 and Corphins Gordon Conference
    CATHERINE DRENNAN; Fiscal Year: 2009
    ..Conditions such as methylmalonic aciduria and homocystinuria are inborn errors of vitamin B12 metabolism. In addition, B12 nutritional deficiencies in the elderly are linked to dementia. ..
  64. 2000 GORDON CONFERENCE ON TETRAPYRROLES
    Paul Ortiz de Montellano; Fiscal Year: 2000
    ....