nalbuphine

Summary

Summary: A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors.

Top Publications

  1. ncbi Absence of nalbuphine anti-analgesia in the rat
    Sachia G Khasar
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neurosci Lett 345:165-8. 2003
  2. pmc A subanalgesic dose of morphine eliminates nalbuphine anti-analgesia in postoperative pain
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
    J Pain 9:337-41. 2008
  3. ncbi Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery
    Evelyne Jacqz-Aigrain
    Paediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Paris, France
    Ther Drug Monit 29:815-8. 2007
  4. ncbi Response of neuropathic trigeminal pain to the combination of low-dose nalbuphine plus naloxone in humans
    Brian L Schmidt
    Department of Oral and Maxillofacial Surgery, C 522 Box 0440, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0440, USA
    Neurosci Lett 343:144-6. 2003
  5. ncbi Efficacy of intramuscular nalbuphine versus diphenhydramine for the prevention of epidural morphine-induced pruritus after cesarean delivery
    Chia Chih Liao
    Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 34:172-8. 2011
  6. pmc Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological fMRI
    Robert Gear
    Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 8:e50169. 2013
  7. ncbi Dose ratio is important in maximizing naloxone enhancement of nalbuphine analgesia in humans
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neurosci Lett 351:5-8. 2003
  8. ncbi Submicron lipid emulsion as a drug delivery system for nalbuphine and its prodrugs
    Jhi Joung Wang
    Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan
    J Control Release 115:140-9. 2006
  9. ncbi Effects of opioids in morphine-treated pigeons trained to discriminate among morphine, the low-efficacy agonist nalbuphine, and saline
    Ellen A Walker
    Department of Psychology, University of North Carolina at Chapel Hill, USA
    J Pharmacol Exp Ther 310:150-8. 2004
  10. ncbi Prevention of emergence agitation after sevoflurane anesthesia for pediatric cerebral magnetic resonance imaging by small doses of ketamine or nalbuphine administered just before discontinuing anesthesia
    Bernard J Dalens
    Department of Anesthesiology, CHUL du Centre Hospitalier Universitaire de Québec, Sainte Foy, Quebec, Canada
    Anesth Analg 102:1056-61. 2006

Research Grants

Detail Information

Publications189 found, 100 shown here

  1. ncbi Absence of nalbuphine anti-analgesia in the rat
    Sachia G Khasar
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neurosci Lett 345:165-8. 2003
    In humans, kappa agonist-antagonist opioids such as nalbuphine have been proposed to produce both analgesia and anti-analgesia by acting at distinct receptors...
  2. pmc A subanalgesic dose of morphine eliminates nalbuphine anti-analgesia in postoperative pain
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
    J Pain 9:337-41. 2008
    The agonist-antagonist kappa-opioid nalbuphine administered for postoperative pain produces greater analgesia in females than in males...
  3. ncbi Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery
    Evelyne Jacqz-Aigrain
    Paediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Paris, France
    Ther Drug Monit 29:815-8. 2007
    ..The present study was undertaken to quantify the transfer of ketoprofen and nalbuphine in milk. Eighteen patients gave their informed consent to participate and completed the study...
  4. ncbi Response of neuropathic trigeminal pain to the combination of low-dose nalbuphine plus naloxone in humans
    Brian L Schmidt
    Department of Oral and Maxillofacial Surgery, C 522 Box 0440, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0440, USA
    Neurosci Lett 343:144-6. 2003
    ..pain in three patients to intravenous administration of a combination of the kappa-partial agonist opioid nalbuphine and the opioid antagonist naloxone...
  5. ncbi Efficacy of intramuscular nalbuphine versus diphenhydramine for the prevention of epidural morphine-induced pruritus after cesarean delivery
    Chia Chih Liao
    Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 34:172-8. 2011
    ..Diphenhydramine is a widely used agent for the treatment of urticarial pruritus. Nalbuphine is a mixed opioid agonist-antagonist and has been reported to be effective in treating opioid-induced pruritus...
  6. pmc Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological fMRI
    Robert Gear
    Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 8:e50169. 2013
    b>Nalbuphine, an agonist-antagonist kappa-opioid, produces brief analgesia followed by enhanced pain/hyperalgesia in male postsurgical patients...
  7. ncbi Dose ratio is important in maximizing naloxone enhancement of nalbuphine analgesia in humans
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neurosci Lett 351:5-8. 2003
    The analgesic effect of kappa partial agonist opioids (i.e. nalbuphine, pentazocine and butorphanol) is significantly greater in women...
  8. ncbi Submicron lipid emulsion as a drug delivery system for nalbuphine and its prodrugs
    Jhi Joung Wang
    Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan
    J Control Release 115:140-9. 2006
    This study investigates the submicron lipid emulsion as a potential parenteral drug delivery system for nalbuphine and its ester prodrugs...
  9. ncbi Effects of opioids in morphine-treated pigeons trained to discriminate among morphine, the low-efficacy agonist nalbuphine, and saline
    Ellen A Walker
    Department of Psychology, University of North Carolina at Chapel Hill, USA
    J Pharmacol Exp Ther 310:150-8. 2004
    In opioid-dependent subjects, the low-efficacy mu agonist nalbuphine generally precipitates withdrawal or withdrawal-like stimulus effects...
  10. ncbi Prevention of emergence agitation after sevoflurane anesthesia for pediatric cerebral magnetic resonance imaging by small doses of ketamine or nalbuphine administered just before discontinuing anesthesia
    Bernard J Dalens
    Department of Anesthesiology, CHUL du Centre Hospitalier Universitaire de Québec, Sainte Foy, Quebec, Canada
    Anesth Analg 102:1056-61. 2006
    ..Small doses of ketamine and nalbuphine provide moderate sedation but their benefits have subsided at the time of emergence...
  11. ncbi Neuroleptics antagonize nalbuphine antianalgesia
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California 94143 0440, USA
    J Pain 7:187-91. 2006
    ..which has minimal effect at sigma receptors, were administered with the agonist-antagonist kappa opioid nalbuphine in patients with postoperative pain...
  12. ncbi Biodegradable polymeric microspheres for nalbuphine prodrug controlled delivery: in vitro characterization and in vivo pharmacokinetic studies
    Fang I Liu
    Department of Pharmacy, Chia Nan University of Pharmacy and Science, 60 Erh Jen Road, Jen Te Hsian, Tainan Hsien 717, Taiwan, ROC
    Int J Pharm 257:23-31. 2003
    ..this work was to study the in vitro characteristics as well as in vivo pharmacokinetic performance of a series nalbuphine (NA) prodrug-loaded microspheres...
  13. pmc Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in men
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:618-32. 2005
    ..We compared the cardiovascular and subjective effects of acute doses of the mu/kappa opioid nalbuphine alone (5 mg/70 kg, intravenous (i.v.)), with cocaine alone (0.2 mg/kg, i.v...
  14. ncbi The effects of electrically assisted methods on transdermal delivery of nalbuphine benzoate and sebacoyl dinalbuphine ester from solutions and hydrogels
    Jeng Fen Huang
    Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan Hsien, Taiwan
    Int J Pharm 297:162-71. 2005
    The aim of this study was to assess the effects of iontophoresis and electroporation on transdermal delivery of nalbuphine (NA) and its two novel prodrugs: nalbuphine benzoate (NAB) and sebacoyl dinalbuphine ester (SDN) from solutions as ..
  15. ncbi A comparison of morphine and nalbuphine for intraoperative and postoperative analgesia
    F N Minai
    Department of Anaesthesiology, The Aga Khan University Hospital, Karachi
    J Pak Med Assoc 53:391-6. 2003
    ....
  16. ncbi Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice
    Eun Joo Shin
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200 701, Republic of Korea
    Drug Alcohol Depend 104:175-84. 2009
    ..Therefore, in this study, possible involvement of the dynorphin gene in nalbuphine-mediated behavioral responses was examined using prodynorphin (Pdyn) gene knock-out (-/-) mice...
  17. ncbi Nalbuphine is effective in decreasing the rewarding effect induced by morphine in rats
    Pao Luh Tao
    Department of Pharmacology, National Defense Medical Center, 161, Min Chuan East Road, Sec 6, Taipei 114, Taiwan, ROC
    Drug Alcohol Depend 84:175-81. 2006
    b>Nalbuphine, a kappa-opioid agonist and mu-opioid partial agonist, has been widely used as an analgesic or an adjuvant with morphine in clinics...
  18. ncbi Nalbuphine prevents haemodynamic response to endotracheal intubation
    Muhammad Ahsan-ul-Haq
    Department of Anaesthesia, Military Hospital, Rawalpindi
    J Coll Physicians Surg Pak 15:668-70. 2005
    To determine the efficacy of nalbuphine in preventing the increase in heart rate and mean arterial pressure in response to laryngoscopy and orotracheal intubation.
  19. ncbi Comparison of fentanyl and nalbuphine in total intravenous anaesthesia (TIVA)
    F A Khan
    Department of Anaesthesiology, The Aga Khan University, Karachi
    J Pak Med Assoc 52:459-65. 2002
    To compare Nalbuphine and fentanyl as total intravenous anaesthesia with propofol infusion in laproscopic cholecystectomy cases.
  20. pmc Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors
    Xuemei Peng
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA
    J Med Chem 50:2254-8. 2007
    ..at one end joined by a chain containing the mu antagonist pharmacophores (naltrexone, naloxone, or nalbuphine) at the other end...
  21. ncbi Attenuation of morphine tolerance and withdrawal syndrome by coadministration of nalbuphine
    Soyong Jang
    Department of Neuroscience, College of Medicine, Ewha Womans University, Seoul, Korea
    Arch Pharm Res 29:677-84. 2006
    ..The purpose of the present study was to investigate whether combined administration of nalbuphine with morphine affects the development of tolerance to and dependence on morphine...
  22. ncbi The peripheral antinociceptive effect of nalbuphine is associated with activation of ATP-sensitive K+ channels
    Mario I Ortiz
    Laboratorio de Farmacología Del Area Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autonoma del Estado de Hidalgo, Eliseo Ramírez Ulloa 400, Col Doctores, Pachuca, Hgo 42090
    Proc West Pharmacol Soc 50:72-4. 2007
    ..Therefore we evaluated the participation of this channel in the antinociceptive action produced by nalbuphine in the formalin test...
  23. ncbi Combination of opioid agonist and agonist-antagonist: patient-controlled analgesia requirement and adverse events among different-ratio morphine and nalbuphine admixtures for postoperative pain
    Y C Yeh
    Department of Anaesthesiology, National Taiwan University Hospital, No 7, Chung San South Road, Taipei, Taiwan, Republic of China
    Br J Anaesth 101:542-8. 2008
    b>Nalbuphine, a mixed agonist-antagonist opioid, has a potential to attenuate the mu-opioid effects and to enhance the kappa-opioid effects...
  24. ncbi Sexual dimorphism in very low dose nalbuphine postoperative analgesia
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neurosci Lett 339:1-4. 2003
    ..that the analgesic effect of the kappa-like opioids is significantly greater in women, that low dose nalbuphine (5 mg) produces profound anti-analgesia (i.e...
  25. ncbi Antinociceptive effect of a novel long-acting nalbuphine preparation
    K S Liu
    Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan
    Br J Anaesth 92:712-5. 2004
    A long-acting analgesic may be particularly desirable in patients suffering from long-lasting pain. The aim of the study was to evaluate the antinociceptive effect of a novel nalbuphine preparation and to determine its duration of action.
  26. ncbi The antinociceptive effect of a long-acting nalbuphine preparation in rabbits
    Shung Tai Ho
    Department of Anesthesiology, Tri Service General Hospital, Taipei, Taiwan, R O C
    Acta Anaesthesiol Sin 41:99-103. 2003
    ..The aim of this study was to evaluate the antinociceptive effect and duration of action of an oily dosage form of nalbuphine base and to see whether its effect could last longer compared with nalbuphine HCl.
  27. ncbi Clocinnamox distinguishes opioid agonists according to relative efficacy in normal and morphine-treated rats trained to discriminate morphine
    Ellen A Walker
    Department of Psychology, Wayne State University, Detroit, Michigan, USA
    J Pharmacol Exp Ther 302:101-10. 2002
    ..and were differentially sensitive to clocinnamox antagonism (fentanyl < morphine < or = buprenorphine = nalbuphine)...
  28. ncbi Effect of nalbuphine on the motility of the sphincter of Oddi in patients with suspected sphincter of Oddi dysfunction
    Laszlo Madacsy
    First Department of Internal Medicine, University of Szeged, Szeged, Hungary
    Gastrointest Endosc 57:319-23. 2003
    b>Nalbuphine is an ideal supplementary analgesic drug for midazolam-induced conscious sedation during operative endoscopy because it has no cardiovascular effect and only a moderate depressive effect on respiration...
  29. ncbi Transdermal delivery of nalbuphine and its prodrugs by electroporation
    K C Sung
    Department of Pharmacy, Chia Nan University of Pharmacy and Science, Jen Te Hsian, Tainan Hsien, Taiwan
    Eur J Pharm Sci 18:63-70. 2003
    The aim of this study was to assess the effects of electroporation on transdermal permeation of nalbuphine (NA) and its prodrugs...
  30. ncbi The analgesic effect of interscalene block using clonidine as an analgesic for shoulder arthroscopy
    Henri Iskandar
    Clinique chirurgicale Bordeaux Mérignac, France
    Anesth Analg 96:260-2, table of contents. 2003
    ..Additional postoperative analgesia was available with parenteral nalbuphine if required until VAS < 3...
  31. ncbi Single bolus of intravenous ketamine for anesthetic induction decreases oculocardiac reflex in children undergoing strabismus surgery
    S H Choi
    Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea
    Acta Anaesthesiol Scand 51:759-62. 2007
    ..The aim of the present study was to determine whether a single bolus of intravenous (i.v.) ketamine for anesthetic induction can decrease OCR in children undergoing strabismus surgery...
  32. ncbi Nalbuphine reverses urinary effects of epidural morphine: a case report
    Jean Marc Malinovsky
    Service d Anesthesie Reanimation, Hotel Dieu, Centre Hospitalier Universitaire de Nantes, Nantes, France
    J Clin Anesth 14:535-8. 2002
    We report the successful use of nalbuphine, a mu-receptor antagonist-kappa-receptor agonist, to reverse the adverse effects on the bladder of epidural morphine.
  33. pmc Hitting them where it hurts? Low dose nalbuphine therapy
    M Woollard
    Pre hospital Emergency Research Unit, Welsh Ambulance Services NHS Trust University of Wales College of Medicine, Cardiff, UK
    Emerg Med J 19:565-70. 2002
    To determine if low dose nalbuphine provides an adequate reduction in pain with minimal side effects.
  34. ncbi Intravenous nalbuphine 50 microg x kg(-1) is ineffective for opioid-induced pruritus in pediatrics
    Nao Nakatsuka
    Department of Anesthesia, Pharmacology and Therapeutics, BC Children s Hospital, University of British Columbia Vancouver, British Columbia, Canada
    Can J Anaesth 53:1103-10. 2006
    This investigation evaluated the efficacy of nalbuphine in treating postoperative opioid-induced pruritus (Pr) in pediatric patients.
  35. pmc Nalbuphine and slow release morphine
    Jason Smith
    Accident and Emergency Department, Derriford Hospital, Plymouth PL6 8DH
    BMJ 328:1426. 2004
  36. ncbi Examination of the interaction between peripheral lumiracoxib and opioids on the 1% formalin test in rats
    Mario I Ortiz
    Área Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autonoma del Estado de Hidalgo, Pachuca, Hidalgo 42090, Mexico
    Eur J Pain 12:233-41. 2008
    ..of the present study was to examine the possible pharmacological interaction between lumiracoxib and codeine or nalbuphine at the local peripheral level in the rat using the 1% formalin test and isobolographic analysis...
  37. ncbi Options in prehospital analgesia
    Meredith L Borland
    Department of Emergency Medicine, Princess Margaret Hospital, Perth Western Australia, Australia
    Emerg Med (Fremantle) 14:77-84. 2002
    ..The present paper identifies the analgesia methods currently available in the prehospital setting so as to evaluate the various options and highlight areas for future research...
  38. pmc Less IS less: a randomised controlled trial comparing cautious and rapid nalbuphine dosing regimens
    M Woollard
    Pre hospital Emergency Research Unit, Welsh Ambulance Services NHS Trust University of Wales College of Medicine, Cardiff, UK
    Emerg Med J 21:362-4. 2004
    This study aimed to determine which of two paramedic administered nalbuphine dosing regimens combined the greater analgesic effect with the minimum of adverse events.
  39. ncbi Characterization and evaluation of silk protein hydrogels for drug delivery
    Jia You Fang
    Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan
    Chem Pharm Bull (Tokyo) 54:156-62. 2006
    ..Furthermore, SPH as an adjuvant polymer in PF-127 and chitosan hydrogels lowered and controlled the amount of drug released from those systems...
  40. pmc Dextromethorphan differentially affects opioid antinociception in rats
    Shiou Lan Chen
    Graduate Institute of Medical Science, National Defense Medical Center, 161 Minchuan East Road, Sec 6 Taipei, Taiwan, Republic of China
    Br J Pharmacol 144:400-4. 2005
    ..c.), meperidine (25 mg kg(-1), s.c.) and codeine (25 mg kg(-1), s.c.), and the kappa-opioid agonists nalbuphine (8 mg kg(-1), s.c.) and U-50,488H (20 mg kg(-1), s.c...
  41. ncbi Postoperative pain management after supratentorial craniotomy
    Eric Verchère
    Department of Anesthesiology 3, University Hospital, Bordeaux, France
    J Neurosurg Anesthesiol 14:96-101. 2002
    ..groups: paracetamol (the P group, n = 8), paracetamol and tramadol (the PT group, n = 29), and paracetamol and nalbuphine (the PN group, n = 27)...
  42. ncbi Interactions between an N-methyl-D-aspartate antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
    J Pharmacol Exp Ther 318:1300-6. 2006
    ..LY235959 and the opioid agonists morphine, buprenorphine, butorphanol, and nalbuphine all decreased rates of schedule-controlled responding...
  43. ncbi Social and environmental influences on opioid sensitivity in rats: importance of an opioid's relative efficacy at the mu-receptor
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, NC 28035 7037, USA
    Psychopharmacology (Berl) 181:27-37. 2005
    ..Evidence indicates that social and environmental enrichment can influence the functional maturation of the central nervous system and may affect an organism's sensitivity to centrally acting drugs...
  44. ncbi [Medical termination of pregnancy at 9-14 weeks gestation. Prospective study of 105 cases in Saint-Laurent-du-Maroni (French Guyana)]
    M Largeaud
    Service de Gynecologie Obstetrique, centre hospitalier de l Ouest guyanais, Saint Laurent du Maroni Guyane française
    J Gynecol Obstet Biol Reprod (Paris) 33:119-24. 2004
    ..To demonstrate the effectiveness and safety of mifepristone 600mg with misoprostol 800 mg, for termination of pregnancy at 9-14 weeks gestation...
  45. ncbi Analgesic and antacid properties of i.m. tramadol given before Caesarean section under general anaesthesia
    M Elhakim
    Department of Anaesthesia, Faculty of Medicine, Ain Sham University, Cairo, Egypt
    Br J Anaesth 95:811-5. 2005
    ..m.) tramadol increases gastric pH during anaesthesia similar to famotidine. We investigated the antacid analgesic value of a single dose of i.m. tramadol given 1 h before elective Caesarean section performed under general anaesthesia...
  46. ncbi Reducing cardiovascular responses to laryngoscopy and tracheal intubation: a comparison of equipotent doses of tramadol, nalbuphine and pethidine, with placebo
    A A van den Berg
    Dept of Anaesthesia, Riyadh Armed Forces Hospital, Riyadh 11159, KSA
    Middle East J Anesthesiol 17:1023-36. 2004
    ..This study examined vasomotor responses to tracheal intubation after equipotent doses of tramadol, nalbuphine and pethidine (3.0, 0.3 mg/kg(-1), and 1...
  47. ncbi The discriminative stimulus effects of morphine in pigeons responding under a progressive ratio schedule of food presentation
    M R Brandt
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans 70112 1393, USA
    Behav Pharmacol 11:15-28. 2000
    ..Buprenorphine substituted for morphine and significantly increased LCR values, whereas nalbuphine produced only partial (20-80%) morphine-key responding and significantly decreased LCR...
  48. ncbi Depression of hepatic glutathione by opioid analgesic drugs in mice
    N P Skoulis
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205
    Toxicol Appl Pharmacol 99:139-47. 1989
    ..caused a significant decrease in hepatic GSH concentrations in male mice while codeine, methadone, butorphanol, nalbuphine, and pentazocine were without effect even at doses up to those approaching acute lethality...
  49. ncbi Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists
    M J Picker
    Department of Psychology, University of North Carolina, Chapel Hill
    J Pharmacol Exp Ther 249:557-66. 1989
    ..The full mu-opioid agonists fentanyl, morphine, I-methadone and levorphanol, as well as the partial agonists nalbuphine, butorphanol and buprenorphine, substituted for the fentanyl stimulus...
  50. ncbi Discriminative stimulus effects of opioids in pigeons trained to discriminate fentanyl, bremazocine and water: evidence of pharmacological selectivity
    M J Picker
    Department of Psychology, University of North Carolina at Chapel Hill 27599 3270, USA
    Behav Pharmacol 8:160-73. 1997
    ..with activity at both the mu and kappa opioid receptor sites, including nalorphine, butorphanol, buprenorphine, nalbuphine, ethylketocyclazocine, (-)-ketocyclazocine, (-)-n-allylnormetazocine (NANM) and levallorphan, produced high ..
  51. ncbi Pain control in first-trimester surgical abortion: a systematic review of randomized controlled trials
    Regina M Renner
    Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA
    Contraception 81:372-88. 2010
    ..First-trimester abortions especially cervical dilation and suction aspiration are associated with pain despite various methods of pain control...
  52. ncbi Acute and chronic morphine administration: effects of mixed-action opioids in rats and squirrel monkeys responding under a schedule of food presentation
    A H Oliveto
    Department of Psychology, University of North Carolina, Chapel Hill 27599 3270
    J Pharmacol Exp Ther 257:8-18. 1991
    ..whereas those for the mu-opioid agonists morphine and I-methadone and mixed-action opioids nalorphine, nalbuphine, butorphanol, pentazocine and bremazocine were unaltered...
  53. ncbi In rats, acute morphine dependence results in antagonist-induced response suppression of intracranial self-stimulation
    Keith W Easterling
    Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA
    Psychopharmacology (Berl) 175:287-95. 2004
    ..Lower (0.001-1.0 mg/kg) doses of the opioid antagonist naltrexone produce few behavioral effects in otherwise drug-free rats responding for ICSS, but reduce response rates by up to 75% after a single dose of morphine...
  54. ncbi The analgesic properties of scalp infiltrations with ropivacaine after intracranial tumoral resection
    Hélène Batoz
    Department of Anesthesiology and Intensive Care Unit III, Pellegrin Hospital, Bordeaux, France
    Anesth Analg 109:240-4. 2009
    ..Accordingly, we designed the present study to test the hypothesis that ropivacaine infiltration of the scalp reduces acute and persistent postoperative pain after intracranial tumor resection...
  55. ncbi Respiratory effects of opioid full and partial agonists in rhesus monkeys
    A Liguori
    Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts, USA
    J Pharmacol Exp Ther 277:462-72. 1996
    ..3-30.0 mg/kg) and the mixed-action opioids buprenorphine (0.003-10.0 mg/kg), butorphanol (0.003-0.3 mg/ kg) and nalbuphine (0.03-30.0 mg/kg) were studied in rhesus monkeys...
  56. ncbi Subjective, psychomotor, and physiological effects of cumulative doses of mixed-action opioids in healthy volunteers
    D J Walker
    University of Chicago, Department of Anesthesia and Critical Care, 5841 S Maryland Avenue, MC 4028, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 155:362-71. 2001
    ..Conducting complete dose-response evaluations of multiple drugs in a single within-subjects experiment is very time-consuming when a complete session is required for evaluation of each dose...
  57. ncbi Combination of low-dose nalbuphine and morphine in patient-controlled analgesia decreases incidence of opioid-related side effects
    Yu Chang Yeh
    Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 108:548-53. 2009
    ..b>Nalbuphine, a mixed opioid agonist-antagonist, may be able to attenuate opioid-related side effects...
  58. ncbi Reversal of fentanyl/fluanisone neuroleptanalgesia in the rabbit using mixed agonist/antagonist opioids
    P A Flecknell
    Comparative Biology Centre, Medical School, Newcastle upon Tyne, UK
    Lab Anim 23:147-55. 1989
    ..All of the compounds studied (naloxone, nalbuphine, meptazinol, butorphanol, buprenorphine, pentazocine, doxapram) reversed the respiratory depression and sedation ..
  59. pmc Activation profiles of opioid ligands in HEK cells expressing delta opioid receptors
    Parham Gharagozlou
    Molecular Research Institute, Mountain View, CA 94043, USA
    BMC Neurosci 3:19. 2002
    ..Activation profiles of most of these ligands at delta opioid receptors had not been previously characterized in vitro. Receptor activation was assessed by measuring the inhibition of forskolin-stimulated cAMP production...
  60. ncbi Age-related differences in sensitivity to the antinociceptive effects of opioids in male rats. Influence of nociceptive intensity and intrinsic efficacy at the mu receptor
    M A Smith
    Department of Psychology, Davidson College, Davidson, NC 28036 1719, USA
    Psychopharmacology (Berl) 156:445-53. 2001
    ..Despite the widespread popularity of opioid analgesics, significant differences in the potency and effectiveness of these drugs are often observed across age groups...
  61. pmc Pharmacological profiles of opioid ligands at kappa opioid receptors
    Parham Gharagozlou
    Department of Pharmacology, Molecular Research Institute, Mountain View, CA 94043, USA
    BMC Pharmacol 6:3. 2006
    ..Intrinsic activities and potencies of these ligands were determined relative to the endogenous ligand dynorphin and the kappa agonist with the highest intrinsic activity that was identified in this study, fentanyl...
  62. ncbi Effects of selected antihypertensives and analgesics on hepatic porphyrin accumulation: implications for clinical porphyria
    R W Lambrecht
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Biochem Pharmacol 58:887-96. 1999
    ..Among the analgesics tested, fentanyl and tramadol produced the highest porphyrin accumulations. Nalbuphine, hydrocodone, oxycodone, and dezocine were moderately or weakly porphyrogenic, whereas buprenorphine and ..
  63. ncbi Antagonism of the discriminative stimulus effects of the kappa-opioid agonist spiradoline
    S G Holtzman
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090
    Psychopharmacology (Berl) 116:243-8. 1994
    ..They spanned a 150-fold potency range from diprenorphine (5 times as potent as naloxone) to nalbuphine (0.03 times as potent as naloxone). Antagonism was stereoselective: 0.1-1...
  64. ncbi Effects of agonist-antagonist opioids in humans trained in a hydromorphone/not hydromorphone discrimination
    K L Preston
    Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 295:114-24. 2000
    ..After training, generalization dose-effect curves for hydromorphone, butorphanol, pentazocine, nalbuphine, and buprenorphine were determined...
  65. ncbi Influence of gonadectomy on the antinociceptive effects of opioids in male and female rats
    Jolan M Terner
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Psychopharmacology (Berl) 163:183-93. 2002
    ..Sex differences in the antinociceptive effects of opioids have been reported in a variety of nociceptive assays, and it has been postulated that these differences are mediated by gonadal hormones...
  66. ncbi Cross-tolerance and enhanced sensitivity to the response rate-decreasing effects of opioids with varying degrees of efficacy at the mu receptor
    M J Picker
    Department of Psychology, University of North Carolina, Chapel Hill 27599 3270
    Psychopharmacology (Berl) 105:459-66. 1991
    ..was also conferred to the intermediate-efficacy mu agonists (-)-pentazocine and (-)-metazocine, but not to nalbuphine or butorphanol...
  67. ncbi Differences in systemic opioid use do not explain increased fever incidence in parturients receiving epidural analgesia
    Jeffrey B Gross
    Department of Anesthesiology, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2015, USA
    Anesthesiology 97:157-61. 2002
    ..If this were the case, then one would expect the incidence of fever in parturients who did not receive systemic opioids to be independent of whether they received epidural analgesia...
  68. ncbi An evaluation of the genotoxicity of the antitussive drug Dextromethorphan
    Marilyn J Aardema
    The Procter and Gamble Co, Miami Valley Innovation Center, P O Box 538707, Cincinnati, OH 45253, USA
    Regul Toxicol Pharmacol 50:285-93. 2008
    ..genotoxicity and carcinogenicity data available on structurally related chemicals including morphine, codeine, nalbuphine, buprenorphine, naloxone, hydromorphone, levorphanol, and oxycodone...
  69. ncbi A review of emergency equipment carried and procedures performed by UK front line paramedics
    Keith Roberts
    Heartlands Hospital, Birmingham, UK
    Resuscitation 58:153-8. 2003
    ..To assess which items of resuscitation equipment are carried on United Kingdom (UK) front line ambulances and what procedures paramedics are able to perform. To compare these findings with those of a previous survey in 1997...
  70. ncbi Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics
    Dorien Groenendaal
    Leiden Amsterdam Center for Drug Research, Leiden University, Division of Pharmacology, PO Box 9502, 2300 RA Leiden, The Netherlands
    Eur J Pharm Sci 34:149-63. 2008
    ..Following intravenous infusion of morphine, alfentanil, fentanyl, sufentanil, butorphanol and nalbuphine the time course of the EEG effect was determined in conjunction with blood concentrations...
  71. ncbi Anaphylaxis during anesthesia - role of skin prick testing in diagnosing multiple sensitivities
    Rashad Siddiqi
    Department of Anesthesia and Intensive Care, CMH, Bahawalpur
    J Coll Physicians Surg Pak 17:219-21. 2007
    ..No sensitivity to Nalbuphine, Thiopentone or Pancuronium was noted...
  72. ncbi Undocumented drug utilization and drug waste increase costs of pediatric anesthesia care
    Alejandro A Nava-Ocampo
    Department of Anesthesia and Respiratory Therapy, Hospital Infantil de Mexico Federico Gomez, Mexico DF, Mexico
    Fundam Clin Pharmacol 18:107-12. 2004
    ..However, rocuronium and nalbuphine had the highest unjustified cost, 770.6 dollars and 847.0 dollars per 100 requested units, respectively...
  73. ncbi Effect of stimulation of the P6 antiemetic point on postoperative nausea and vomiting
    J W Dundee
    Department of Anaesthetics, Queen s University of Belfast, Ireland
    Br J Anaesth 63:612-8. 1989
    ..action of stimulation of the P6 (Neiguan) acupuncture (ACP) point has been studied in women, premedicated with nalbuphine 10 mg, undergoing minor gynaecological operations under methohexitone-nitrous oxide-oxygen anaesthesia...
  74. pmc The effects of repeated opioid administration on locomotor activity: I. Opposing actions of mu and kappa receptors
    Mark A Smith
    Department of Psychology and Program in Neuroscience, Davidson College, Davidson, North Carolina, USA
    J Pharmacol Exp Ther 330:468-75. 2009
    ..administration of high doses, but not low or moderate doses, of the mixed mu/kappa agonists butorphanol, nalbuphine, and nalorphine produced a progressive increase in locomotor activity during the treatment period...
  75. pmc Antinociceptive interactions between Mu-opioid receptor agonists and the serotonin uptake inhibitor clomipramine in rhesus monkeys: role of Mu agonist efficacy
    Matthew L Banks
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, P O Box 980613, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 335:497-505. 2010
    ..on behavioral effects produced in rhesus monkeys by mu agonists with varying efficacy at mu receptors (nalbuphine < morphine < methadone)...
  76. ncbi A mechanistic model for the sex-specific response to nalbuphine and naloxone in postoperative pain
    Smita Kshirsagar
    Department of Medicine, Stanford University Medical Center, Stanford, CA, USA
    J Pharmacokinet Pharmacodyn 35:69-83. 2008
    ..model for post-operative pain and apply it to describe the pharmacodynamic effects of the kappa-opioids nalbuphine and naloxone administered either alone or in combination in patients after surgical removal of one or more ..
  77. ncbi Epidural nalbuphine for post cesarean epidural morphine induced pruritus
    Orawan Pongraweewan
    Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 92:782-6. 2009
    The aim of the present study was to test the efficacy of epidural nalbuphine 5 mg for prevention of morphine-induced pruritus.
  78. ncbi Recent developments in the chemistry of thebaine and its transformation products as pharmacological targets
    Sándor Berényi
    Department of Organic Chemistry, University of Debrecen, Debrecen, Hungary
    Curr Med Chem 16:3215-42. 2009
    ..synthetic routes to the preparation of as important pharmaceuticals as oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid, thebaine, as a starting material...
  79. ncbi Continuous epidural block versus continuous popliteal nerve block for postoperative pain relief after major podiatric surgery in children: a prospective, comparative randomized study
    Christophe Dadure
    Department of Anesthesia, Lapeyronie University Hospital, Montpellier, France
    Anesth Analg 102:744-9. 2006
    ..Requirement for rescue analgesia (first-line propacetamol 30 mg/kg 4 times daily or second-line 0.2 mg/kg IV nalbuphine), and motor blockade were recorded. Parental satisfaction was noted at 48 h...
  80. ncbi Pharmacogenetic analysis of sex differences in opioid antinociception in rats
    Jolan M Terner
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Pain 106:381-91. 2003
    ..with the high-efficacy micro-opioid morphine, and the less efficacious opioids buprenorphine, butorphanol and nalbuphine. Baseline nociceptive latencies were consistently higher in males than their female counterparts...
  81. pmc The effects of repeated opioid administration on locomotor activity: II. Unidirectional cross-sensitization to cocaine
    Mark A Smith
    Department of Psychology, Davidson College, Davidson, North Carolina 28035 7037, USA
    J Pharmacol Exp Ther 330:476-86. 2009
    ..The mixed mu/kappa opioids butorphanol, nalbuphine, and nalorphine did not produce cross-sensitization under any condition examined...
  82. ncbi Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model
    M J Clark
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Mol Pharmacol 73:1538-48. 2008
    ..inhibition of forskolin-stimulated adenylyl cyclase by the low-efficacy partial agonists buprenorphine and nalbuphine was increased in cells expressing RGS-insensitive Galpha(o)(CIGS), Galpha(i2)(CIGS), or Galpha(i3)(CIGS) ..
  83. ncbi Efficacy and safety of mu-opioid antagonists in the treatment of opioid-induced bowel dysfunction: systematic review and meta-analysis of randomized controlled trials
    Ewan McNicol
    Department of Pharmacy, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Pain Med 9:634-59. 2008
    ..OBD occurs both acutely and chronically, in multiple disease states, resulting in increased morbidity and reduced quality of life...
  84. ncbi Results of forty years Yellow Card reporting for commonly used perioperative analgesic drugs
    Jennifer Richardson
    Imperial College London, UK
    Pharmacoepidemiol Drug Saf 16:687-94. 2007
    ..A variety of analgesics are used perioperatively and associated adverse drug reactions (ADRs) may complicate anaesthesia and recovery...
  85. ncbi Laparoscopic transperitoneal and retroperitoneal nephrectomies in children: a change of practice
    Julio J N Baez
    Department of Pediatric Surgery, Municipal Children s Hospital of Córdoba, Department of Pediatric Surgery, National University of Cordoba, Cordoba, Argentina
    J Laparoendosc Adv Surg Tech A 20:81-5. 2010
    ..Laparoscopic nephrectomies (LNs) may be performed in children with benign renal disease by the transperitoneal (TP) or retroperitoneal (RP) approach...
  86. ncbi Sex differences in the potency of kappa opioids and mixed-action opioids administered systemically and at the site of inflammation against capsaicin-induced hyperalgesia in rats
    Lisa M Lomas
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Psychopharmacology (Berl) 191:273-85. 2007
    ....
  87. pmc Syntheses of novel high affinity ligands for opioid receptors
    Mark P Wentland
    Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Bioorg Med Chem Lett 19:2289-94. 2009
    A series of novel high affinity opioid receptor ligands have been made whereby the phenolic-OH group of nalbuphine, naltrexone methiodide, 6-desoxonaltrexone, hydromorphone and naltrindole was replaced by a carboxamido group and the furan ..
  88. ncbi The use of intravenous nitroglycerin in a case of spasm of the sphincter of Oddi during laparoscopic cholecystectomy
    H Toyoyama
    Department of Anesthesia, Osaka Kosei Nenkin Hospital, Japan
    Anesthesiology 94:708-9. 2001
    ..Some reports indicate that the spasm, induced by morphine, can be reversed by injection of naloxone, nalbuphine, and glucagon. Others maintain that nitroglycerin or nifedipine can relax the sphincter of Oddi muscle...
  89. ncbi Predictive factors of PACU stay after herniorraphy in infant: a classification and regression tree analysis
    Vilnis Silins
    Department of Anesthesia, Intensive Care and Pain Management, Robert Debre University Hospital, Paris Diderot University, Paris Sorbonne Cité, Paris, France
    Paediatr Anaesth 22:230-8. 2012
    ..However, their influence upon PACU stay duration has not been evaluated. The goal of this study was to investigate predictive factors for PACU stay in infants undergoing herniorraphy...
  90. ncbi Antinociceptive effects of long-acting nalbuphine decanoate after intramuscular administration to Hispaniolan Amazon parrots (Amazona ventralis)
    David Sanchez-Migallon Guzman
    Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Vet Res 74:196-200. 2013
    To evaluate the thermal antinociceptive effects and duration of action of nalbuphine decanoate after IM administration to Hispaniolan Amazon parrots (Amazona ventralis).
  91. ncbi Simultaneous determination of nalbuphine and its prodrug sebacoly dinalbuphine ester in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in humans
    Pei Wei Huang
    School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Biomed Chromatogr 27:831-7. 2013
    ..ultraperformance liquid chromatography-tandem spectrometry (UPLC-MS/MS) method for the determination of nalbuphine and its prodrug sebacoly dinalbuphine ester (SDE) was developed and validated in human plasma...
  92. ncbi Interaction of nalbuphine hydrochloride with deoxyribonucleic acid measured by fluorescence quenching
    S Sultana
    Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
    Drug Res (Stuttg) 63:224-7. 2013
    The interaction of nalbuphine hydrochloride with calf thymus deoxyribonucleic acid was investigated by absorption and fluorescence titration techniques. Hypochromic effect was observed in the absorption spectra of nalbuphine...
  93. ncbi Dose-dependent attenuation of intravenous nalbuphine on epidural morphine-induced pruritus and analgesia after cesarean delivery
    Mao Kai Chen
    Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan
    Kaohsiung J Med Sci 30:248-53. 2014
    ..designed to evaluate the efficacy and safety profile of patient-controlled antipruritus (PCP) use of intravenous nalbuphine-based regimens for attenuation of postoperative pruritus and related side effects in combination with epidural ..
  94. ncbi [Alternative techniques to labour epidural analgesia]
    M Bruyere
    Departement d Anesthesie Reanimation, Hopital Antoine Beclere, 92141 Clamart Cedex, France
    Ann Fr Anesth Reanim 24:1375-82. 2005
    ..Pethidine should be abandoned because it can produce prolonged neonatal respiratory depression. Nalbuphine produces less nausea/vomiting and less long lasting neonatal respiratory depression...
  95. ncbi Novel combinations of nalbuphine and medetomidine for wildlife immobilization
    Lisa L Wolfe
    1 Colorado Division of Parks and Wildlife, Wildlife Health Program, 4330 Laporte Avenue, Fort Collins, Colorado 80521 2153, USA
    J Wildl Dis 50:951-6. 2014
    We formulated novel drug combinations of nalbuphine HCl and medetomidine HCl (NalMed), with or without azaperone tartrate, for use in immobilizing Rocky Mountain elk (Cervus elaphus nelsoni) and potentially for other wildlife species...
  96. ncbi Comparison between tramadol hydrochloride & nalbuphine hydrochloride in the treatment of per-operative shivering after spinal anaesthesia
    M F Haque
    Department of Anaesthesia and Intensive Care Unit, Mymensingh Medical College and Hospital, Mymensingh, Bangladesh
    Mymensingh Med J 20:201-5. 2011
    ..And shivering was better managed by administration of nalbuphine HCl and surface skin warming (wrapping of the skin)...
  97. ncbi Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation
    Mary J Clark
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109 0632, USA
    J Pharmacol Exp Ther 317:858-64. 2006
    ..DAMGO = endomorphin-1 = endomorphin-2 = fentanyl > or = morphine > or = meperidine > buprenorphine > or = nalbuphine, was also the same across all of the PTX-insensitive Galpha(i/o) subtypes...
  98. ncbi The impact of parenteral narcotic choice in the development of acute chest syndrome in sickle cell disease
    Karen Lewing
    Department of Pediatrics, Children s Mercy Hospital, Kansas City, MO 64108, USA
    J Pediatr Hematol Oncol 33:255-60. 2011
    ..Painful episodes which require hospitalization are most often treated with opioids, which may then influence the development of ACS. Nalbuphine is a parenteral opioid which effectively treats pain and may cause less ACS.
  99. ncbi Management of hypertrophic pylorus stenosis with ultrasound guided single shot epidural anaesthesia--a retrospective analysis of 20 cases
    Harald Willschke
    Department of Anaesthesia, Intensive Care Medicine and Pain Therapy, Medical University of Vienna, Vienna, Austria
    Paediatr Anaesth 21:110-5. 2011
    ..To retrospectively describe the performance of ultrasound guided thoracic epidural anaesthesia under sedation for anaesthesia management of open pyloromyotomy...
  100. ncbi Tramadol versus nalbuphine in total intravenous anaesthesia for dilatation and evacuation
    Khalid Maudood Siddiqui
    Department of Anaesthesia, Aga Khan University Hospital, Karachi
    J Pak Med Assoc 57:67-70. 2007
    To compare the results of Tramadol with Nalbuphine for dilatation and evacuation with total intravenous anaesthesia technique.
  101. ncbi Reflex activity caused by laryngoscopy and intubation is obtunded differently by meptazinol, nalbuphine and fentanyl
    E Freye
    Heinrich Heine University of Dusseldorf, Clinics of Vascular Surgery and Renal Transplantation, Dusseldorf, Germany
    Eur J Anaesthesiol 24:53-8. 2007
    ..To evaluate the different potencies of several opioids in obtunding reflex mechanisms of laryngoscopy and intubation...

Research Grants24

  1. Opioid Antagonist Discrimination: A Model of Withdrawal
    Alison Oliveto; Fiscal Year: 2011
    ..we showed that the opioid agonist hydromorphone blocks the effects of NX while the partial opioid agonists nalbuphine and butorphanol, and the alpha2-adrenergic (A2A) antagonist yohimbine produced NX-like effects...
  2. BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERS
    James Zacny; Fiscal Year: 2003
    ..a painful stimulus modulates the subjective and psychomotor effects of morphine, meperidine, butorphanol and nalbuphine. We will study different opioids at different doses and at different levels of painful stimulation in order to ..
  3. GENDER AND SEX HORMONES AND OPIOID ANALGESIA
    Jon Levine; Fiscal Year: 2006
    ..This finding was observed with three different opioid analgesics that are k-partial agonists: pentazocine, nalbuphine and butorphanol...
  4. Primate Model of the Transition to Cocaine Addiction
    JAMES ROWLETT; Fiscal Year: 2005
    ..The results will provide needed information for developing a nonhuman primate model that can serve as a quantitative platform for future research on neuroadaptations underlying the transition to persistent cocaine self-administration. ..
  5. Nonhuman Primate Model of Benzodiazepine Relapse
    JAMES ROWLETT; Fiscal Year: 2002
    ....
  6. Behavioral Economic Analysis of Polydrug Abuse
    GAIL D WINGER; Fiscal Year: 2010
    ....
  7. BIOBEHAVIORAL STUDIES OF SUBSTANCE ABUSE
    NANCY MELLO; Fiscal Year: 2008
    ..abstract_text> ..
  8. kappa-agonist effects of the hallucinogen Salvinorin A
    Eduardo Butelman; Fiscal Year: 2008
    ....
  9. AMINOBENZOMORPHAN: POTENTIAL COCAINE ABUSE MEDICATIONS
    Mark Wentland; Fiscal Year: 2009
    ..Radioligand binding, [35S]GTPvS, and mouse antinociceptive assays will be used to characterize new targets pharmacologically. ..
  10. Role of Lipid Rafts in Adenylyl Cyclase Sensitization
    John Traynor; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  11. Novel Delta Opioids: Analgesic Effects & Abuse Liability
    SIDNEY NEGUS; Fiscal Year: 2009
    ....
  12. Sex-Related Genetic Influences on Pain and Analgesia
    Roger Fillingim; Fiscal Year: 2009
    ....
  13. OPIOID RECEPTOR MECHANISMS
    John R Traynor; Fiscal Year: 2010
    ..An understanding of roles for RGS proteins in the actions of mu-opioids may lead to improvements in the treatment of pain as well as treatment of opioid and stimulant abuse. ..
  14. Morphine/NMDA interactions: Antinociceptive and discriminative stimulus effects
    BRADFORD FISCHER; Fiscal Year: 2007
    ..Findings from these experiments may have important clinical implications, and may lead to new pharmacotherapeutic strategies in the treatment of pain and drug abuse. [unreadable] [unreadable] [unreadable]..
  15. Ethnic Differences in Responses to Painful Stimuli
    Roger Fillingim; Fiscal Year: 2006
    ..The results of this research will provide unique and important information regarding ethnic differences in pain responses. ..
  16. EFFECTS OF SYSTEMICALLY ADMINISTERED DYNORPHINS
    Eduardo Butelman; Fiscal Year: 2002
    ....
  17. Sex Diffrerences in Opioid Antinociception
    Andrew Barrett; Fiscal Year: 2003
    ....
  18. STIMULANTS, DEPRESSANTS & HALLUCINOGENS AS REINFORCERS
    Gail Winger; Fiscal Year: 2003
    ..These drugs can be those that the WHO or the FDA is considering for scheduling decisions, drugs made by industrial or academic medicinal chemists, or industrial drugs that are being considered for clinical testing. ..
  19. Cocaine Abuse and the Role of Gonadal Steroid Hormones
    NANCY MELLO; Fiscal Year: 2005
    ..Data obtained will help to clarify the neurobiologic substrates of cocaine abuse and may have heuristic implications for the development of new strategies for treatment. ..
  20. Measuring and Modifying Ethanol's Reinforcing Effects
    Gail Winger; Fiscal Year: 2006
    ..Data relevant to the behavioral and pharmacological mechanisms underlying polydrug abuse involving ethanol, and underlying pharmacological treatment of alcoholism will also be obtained. ..
  21. Behavioral Pharmacology of Serotonin Inverse Agoinsts
    Ellen Walker; Fiscal Year: 2006
    ..Taken together, these experiments will provide a novel pharmacological and/or behavioral profile for 5-HT2C inverse agonists and neutral antagonists while testing hypotheses generated from in vitro data. ..
  22. 2,5 CYCLOHEXADIENONES IN NATURAL PRODUCTS SYNTHESIS
    Mark Wentland; Fiscal Year: 2001
    ....
  23. "Post-partum steroid withdrawal-induced depression"
    REBECCA CRAFT; Fiscal Year: 2006
    ..Findings from the proposed model will enhance our understanding of the etiology of PPD and possibly lead to improved treatment options. ..
  24. Society for the Stimulus Properties of Drugs Satellite
    Ellen Walker; Fiscal Year: 2005
    ..The SSPD Satellite to the EBPS 2005 Conference promises to coordinate, exchange, and disseminate information to further our understanding of drug abuse. ..