hydrocodone

Summary

Summary: Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.

Top Publications

  1. ncbi Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back pain
    Mark Palangio
    Abbott Laboratories, Parsippany, New Jersey 07054, USA
    Clin Ther 24:87-99. 2002
  2. ncbi Evaluation of postoperative bupivacaine infusion for pain management after anterior cruciate ligament reconstruction
    J Winslow Alford
    Department of Orthopedic Surgery, Division of Sports Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
    Arthroscopy 19:855-61. 2003
  3. ncbi Analgesic efficacy and tolerability of oxycodone 5 mg/ibuprofen 400 mg compared with those of oxycodone 5 mg/acetaminophen 325 mg and hydrocodone 7.5 mg/acetaminophen 500 mg in patients with moderate to severe postoperative pain: a randomized, double-blin
    Leonard J Litkowski
    Center for Clinical Studies, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    Clin Ther 27:418-29. 2005
  4. ncbi The efficacy of rofecoxib 50 mg and hydrocodone/acetaminophen 7.5/750 mg in patients with post-arthroscopic pain
    Jacques E Chelly
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Curr Med Res Opin 23:195-206. 2007
  5. ncbi Opioids in the management of chronic non-cancer pain: an update of American Society of the Interventional Pain Physicians' (ASIPP) Guidelines
    Andrea M Trescot
    American Society of Interventional Pain Physicians, Paducah, KY 42001, USA
    Pain Physician 11:S5-S62. 2008
  6. ncbi Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers
    Jose de Leon
    J Clin Psychopharmacol 23:420-1. 2003
  7. pmc Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens
    Marco Pravetoni
    Minneapolis Medical Research Foundation, 701 Park Avenue, Minneapolis, Minnesota 55404, USA
    J Med Chem 56:915-23. 2013
  8. pmc The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers
    Sharon L Walsh
    Department of Behavioral Sciences, Center on Drug and Alcohol Research, University of Kentucky, 515 Oldham Court, Lexington, KY 40502, USA
    Drug Alcohol Depend 98:191-202. 2008
  9. ncbi Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer
    Margaret T Susce
    University of Kentucky, Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:1356-8. 2006
  10. ncbi Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of postoperative obstetric or gynecologic pain
    M Palangio
    Medical Affairs Department, Knoll Pharmaceutical Company, Mount Olive, New Jersey 07828 1234, USA
    Clin Ther 22:600-12. 2000

Detail Information

Publications208 found, 100 shown here

  1. ncbi Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back pain
    Mark Palangio
    Abbott Laboratories, Parsippany, New Jersey 07054, USA
    Clin Ther 24:87-99. 2002
    Introduced in 1997, the combination of hydrocodone and ibuprofen is the only fixed-dose combination analgesic containing an opioid and ibuprofen that has been approved by the US Food and Drug Administration.
  2. ncbi Evaluation of postoperative bupivacaine infusion for pain management after anterior cruciate ligament reconstruction
    J Winslow Alford
    Department of Orthopedic Surgery, Division of Sports Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
    Arthroscopy 19:855-61. 2003
    ..We endeavored to evaluate the efficacy of one such device currently in use...
  3. ncbi Analgesic efficacy and tolerability of oxycodone 5 mg/ibuprofen 400 mg compared with those of oxycodone 5 mg/acetaminophen 325 mg and hydrocodone 7.5 mg/acetaminophen 500 mg in patients with moderate to severe postoperative pain: a randomized, double-blin
    Leonard J Litkowski
    Center for Clinical Studies, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    Clin Ther 27:418-29. 2005
    ..Combination therapy has been widely used for the clinical management of acute pain. By combining 2 drugs with different mechanisms of action, such therapy provides additive analgesic effects while reducing the risk for adverse effects...
  4. ncbi The efficacy of rofecoxib 50 mg and hydrocodone/acetaminophen 7.5/750 mg in patients with post-arthroscopic pain
    Jacques E Chelly
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Curr Med Res Opin 23:195-206. 2007
    To compare the efficacy and tolerability of rofecoxib, hydrocodone/acetaminophen 7.5 mg/750 mg (H/A) and placebo in treating pain after arthroscopy of the knee.
  5. ncbi Opioids in the management of chronic non-cancer pain: an update of American Society of the Interventional Pain Physicians' (ASIPP) Guidelines
    Andrea M Trescot
    American Society of Interventional Pain Physicians, Paducah, KY 42001, USA
    Pain Physician 11:S5-S62. 2008
    ..Available evidence suggests a continued wide variance in the use of opioids, as documented by different medical specialties, medical boards, advocacy groups, and the Drug Enforcement Administration...
  6. ncbi Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers
    Jose de Leon
    J Clin Psychopharmacol 23:420-1. 2003
  7. pmc Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens
    Marco Pravetoni
    Minneapolis Medical Research Foundation, 701 Park Avenue, Minneapolis, Minnesota 55404, USA
    J Med Chem 56:915-23. 2013
    ..In this study, oxycodone-based and hydrocodone-based haptens were conjugated to KLH to generate immunogens that would recognize both oxycodone and hydrocodone...
  8. pmc The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers
    Sharon L Walsh
    Department of Behavioral Sciences, Center on Drug and Alcohol Research, University of Kentucky, 515 Oldham Court, Lexington, KY 40502, USA
    Drug Alcohol Depend 98:191-202. 2008
    ..design to examine the relative abuse potential and potency of oral oxycodone (10, 20 and 40 mg), hydrocodone (15, 30 and 45 mg), hydromorphone (10, 17.5 and 25mg) and placebo...
  9. ncbi Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer
    Margaret T Susce
    University of Kentucky, Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:1356-8. 2006
    ..CYP2D6 metabolizes other opioid analgesics, including tramadol, dihydrocodeine, oxycodone and hydrocodone, although they have been less systematically studied...
  10. ncbi Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of postoperative obstetric or gynecologic pain
    M Palangio
    Medical Affairs Department, Knoll Pharmaceutical Company, Mount Olive, New Jersey 07828 1234, USA
    Clin Ther 22:600-12. 2000
    The objective of this study was to compare the effectiveness of combination hydrocodone and ibuprofen with that of combination oxycodone and acetaminophen in the treatment of moderate to severe postoperative obstetric or gynecologic pain.
  11. pmc A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy
    Kimberly A Sutters
    Children s Hospital Central California, Madera, CA 93636 8761, USA
    Clin J Pain 26:95-103. 2010
    ..To determine the effectiveness of around-the-clock (ATC) analgesic administration, with or without nurse coaching, compared with standard care with as needed (PRN) dosing in children undergoing outpatient tonsillectomy...
  12. ncbi Subjective, psychomotor, and physiological effects profile of hydrocodone/acetaminophen and oxycodone/acetaminophen combination products
    James P Zacny
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
    Pain Med 9:433-43. 2008
    To compare within the same individuals two typically prescribed doses of hydrocodone/acetaminophen and oxycodone/acetaminophen products for their subjective, psychomotor, and physiological effects in healthy volunteers.
  13. ncbi Hydrocodone use and sensorineural hearing loss
    Tang Ho
    Baylor College of Medicine, Houston, TX, USA
    Pain Physician 10:467-72. 2007
    The hydrocodone/acetaminophen combination is one of the most commonly used analgesic preparations. Isolated incidences of suspected association between hydrocodone abuse and rapidly progressive hearing loss have been reported...
  14. ncbi Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions
    Parvaz Madadi
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8
    Pediatrics 126:e986-9. 2010
    ..in a developmentally delayed child aged 5 years 9 months who was inadvertently administered high doses of hydrocodone for a respiratory tract infection...
  15. ncbi Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain
    M Palangio
    Medical Affairs Department, Knoll Pharmaceutical Company, Mount Olive, New Jersey 07828 1234, USA
    Clin Ther 22:879-92. 2000
    The objective of this study was to compare the effectiveness of combination hydrocodone 7.5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain.
  16. ncbi A comparison of the abuse liability of tramadol, NSAIDs, and hydrocodone in patients with chronic pain
    Edgar H Adams
    Edgar Adams Consulting, Covance, Princeton, New Jersey 08540, USA
    J Pain Symptom Manage 31:465-76. 2006
    ..was to assess the prevalence of tramadol abuse compared to nonsteroidal anti-inflammatory drugs (NSAIDs) and hydrocodone-containing analgesics in patients with chronic noncancer pain (CNP). The study had three arms...
  17. pmc Intravenous oxycodone, hydrocodone, and morphine in recreational opioid users: abuse potential and relative potencies
    William W Stoops
    Department of Behavioral Science, University of Kentucky College of Medicine, 140 Medical Behavioral Science Building, Lexington, KY 40536 0086, USA
    Psychopharmacology (Berl) 212:193-203. 2010
    ....
  18. ncbi Randomized double-blind placebo controlled crossover study of acetaminophen, ibuprofen, acetaminophen/hydrocodone, and placebo for the relief of pain from a standard painful stimulus
    James R Miner
    Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN, USA
    Acad Emerg Med 16:911-4. 2009
    ..The objective was to compare subjects' change in perceived acute pain from an identical painful stimulus after receiving three separate, commonly used pain medications and placebo...
  19. pmc Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial
    D Stolz
    Division of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
    Thorax 59:773-6. 2004
    ..A randomised, placebo controlled, double blind study was undertaken to determine whether hydrocodone in combination with midazolan improves cough suppression during FB without increasing the risk of desaturation.
  20. ncbi A double-blind, single-dose comparison of the analgesic efficacy of tramadol/acetaminophen combination tablets, hydrocodone/acetaminophen combination tablets, and placebo after oral surgery
    James R Fricke
    Austin Oral Surgery Associates, Texas 78703, USA
    Clin Ther 24:953-68. 2002
    ..However, because not all combinations or dose ratios lead to enhanced analgesia or reduced adverse events (AEs), each combination and dose ratio must be evaluated individually in carefully designed preclinical and clinical trials...
  21. ncbi Patient characteristics and risks factors for development of dependence on hydrocodone and oxycodone
    Norman S Miller
    Department of Psychiatry, College of Human Medicine, Michigan State University, A227 East Fee Hall, East Lansing, MI 48824 1316, USA
    Am J Ther 11:26-32. 2004
    The purpose of the study was to document the substantial increase in problematic use of hydrocodone and oxycodone in an addiction treatment population...
  22. ncbi GC-MS quantitation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in blood
    Robert Meatherall
    Department of Biochemistry, St Boniface General Hospital, Winnipeg, Manitoba, Canada
    J Anal Toxicol 29:301-8. 2005
    A method is described for the simultaneous analysis of seven opiates, codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone, in blood samples by gas chromatography-mass spectrometry (GC-MS)...
  23. ncbi Rofecoxib versus hydrocodone/acetaminophen for postoperative analgesia in functional endoscopic sinus surgery
    Christopher A Church
    Division of Otolaryngology Head and Neck Surgery, Loma Linda University School of Medicine, Loma Linda, California 92354, USA
    Laryngoscope 116:602-6. 2006
    ..Nonopioid analgesics have been suggested to offer similar pain control efficacy with fewer adverse effects...
  24. ncbi A phase II study of hydrocodone for cough in advanced cancer
    Jade Homsi
    Harry R Horvitz Center for Palliative Medicine a World Health Organization demonstration project in palliative medicine, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 19:49-56. 2002
    Cough is a common symptom in advanced cancer. The use of hydrocodone as an antitussive has not been studied previously in this setting. This study evaluates hydrocodone for cough in advanced cancer
  25. pmc CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia, 5005
    Br J Clin Pharmacol 57:287-97. 2004
    To determine the Michaelis-Menten kinetics of hydrocodone metabolism to its O- and N-demethylated products, hydromorphone and norhydrocodone, to determine the individual cytochrome p450 enzymes involved, and to predict the in vivo ..
  26. ncbi Simultaneous determination of codeine, morphine, hydrocodone, hydromorphone, oxycodone, and 6-acetylmorphine in urine, serum, plasma, whole blood, and meconium by LC-MS-MS
    Rebecka Coles
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories Inc, Salt Lake City, Utah 84108, USA
    J Anal Toxicol 31:1-14. 2007
    ..The six opiates included are codeine, morphine, hydrocodone, hydromorphone, oxycodone, and 6-acetylmorphine (6-AM)...
  27. ncbi GC-MS confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine
    R Meatherall
    Department of Biochemistry, St Boniface General Hospital, Winnipeg, Manitoba, Canada
    J Anal Toxicol 23:177-86. 1999
    A procedure for the simultaneous confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine specimens by gas chromatography-mass spectrometry (GC-MS) is described...
  28. ncbi Dental therapeutic practice patterns in the U.S. II. Analgesics, corticosteroids, and antibiotics
    Paul A Moore
    Oral Health Science Institute, University of Pittsburgh School of Dental Medicine, USA
    Gen Dent 54:201-7; quiz 208, 221-2. 2006
    ..The centrally acting analgesic prescribed most frequently was the combination formulation of hydrocodone with acetaminophen, selected by 64.0% of the respondents...
  29. ncbi Patient-controlled ropivacaine analgesia after arthroscopic subacromial decompression
    Gregory P Harvey
    Sports Medicine Service, Department of Orthopedics, USA
    Arthroscopy 20:451-5. 2004
    ..To evaluate the efficacy of a subacromial patient-controlled analgesia (PCA) infusion of 0.2% ropivacaine versus saline for postoperative pain control following arthroscopic shoulder surgery...
  30. ncbi Trends and geographic variation of opiate medication use in state Medicaid fee-for-service programs, 1996 to 2002
    Judy T Zerzan
    HSR and D Department of Veterans Affairs, Puget Sound Health Care System, Seattle, WA 98101, USA
    Med Care 44:1005-10. 2006
    ..This study describes temporal and interstate variability in aggregate prescription opiate medication use within U.S. Medicaid programs...
  31. ncbi The availability of web sites offering to sell opioid medications without prescriptions
    Robert F Forman
    Medical Affairs Alkermes, Inc, 88 Sidney St, Cambridge, MA 02139, USA
    Am J Psychiatry 163:1233-8. 2006
    ..This study was designed to determine the availability of web sites offering to sell opioid medications without prescriptions...
  32. ncbi Therapeutic opioids: a ten-year perspective on the complexities and complications of the escalating use, abuse, and nonmedical use of opioids
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, KY 42003, USA
    Pain Physician 11:S63-88. 2008
    ..6% of the world's population, have been consuming 80% of the global opioid supply, and 99% of the global hydrocodone supply, as well as two-thirds of the world's illegal drugs...
  33. ncbi Efficacy of ibuprofen-hydrocodone for the treatment of postoperative pain after periodontal surgery
    James W Betancourt
    Mayo Clinic, Department of Dental Specialties, Rochester, MN, USA
    J Periodontol 75:872-6. 2004
    ..The purpose of this study was to compare an alternative combination of ibuprofen 400 mg with 5 mg of hydroxycodone to ibuprofen 400 mg used alone in the management of pain following periodontal surgery...
  34. ncbi Zolpidem reduces postoperative pain, fatigue, and narcotic consumption following knee arthroscopy: a prospective randomized placebo-controlled double-blinded study
    Robert Z Tashjian
    Department of Orthopedic Surgery, Brown Medical School, Providence, RI, USA
    J Knee Surg 19:105-11. 2006
    ..All groups received postoperative hydrocodone and ibuprofen...
  35. ncbi Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial
    Rene Fernando Rodriguez
    Universidad Libre de Cali, Cali, Valle, Colombia
    Clin J Pain 24:1-4. 2008
    The purpose of this study was to compare the analgesic efficacy and tolerability of opioids hydrocodone and tramadol in the relief of cancer pain.
  36. ncbi Overriding the blockade of antinociceptive actions of opioids in rats treated with extended-release naltrexone
    Reginald L Dean
    Department of Life Sciences and Toxicology, Alkermes, Inc, 88 Sidney St, Cambridge, MA 02139, USA
    Pharmacol Biochem Behav 89:515-22. 2008
    ..In naïve rats, 15 mg/kg morphine, 0.1 mg/kg fentanyl and 8 mg/kg hydrocodone produced MRL...
  37. ncbi Trends in abuse of Oxycontin and other opioid analgesics in the United States: 2002-2004
    Theodore J Cicero
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Pain 6:662-72. 2005
    ..The prevalence of abuse was rank ordered as follows: OxyContin >or= hydrocodone > other oxycodone > methadone > morphine > hydromorphone > fentanyl > buprenorphine...
  38. ncbi Postoperative epidural morphine for postpartum tubal ligation analgesia
    R Jay L Marcus
    Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, 251 E Huron, F 5 704, Chicago, IL 60611, USA
    Anesth Analg 101:876-81, table of contents. 2005
    ..Postoperatively, ibuprofen 600 mg was administered every 6 h and patients could request acetaminophen 325 mg/hydrocodone 10 mg. The primary outcome variable was time to first request for supplemental analgesia...
  39. pmc Drug therapy in dental practice: nonopioid and opioid analgesics
    Daniel E Becker
    Sinclair Community College, Dayton, Ohio, USA
    Anesth Prog 52:140-9. 2005
    ..The clinician can and should develop a variety of effective, safe analgesic regimens, based on estimates of anticipated pain intensity that use sound pharmacological principles...
  40. ncbi Preoperative "fentanyl challenge" as a tool to estimate postoperative opioid dosing in chronic opioid-consuming patients
    Jennifer J Davis
    Department of Anesthesiology, University of Utah Medical Center, 30 North 1900 East, Room 3C 444, Salt Lake City, UT 84132, USA
    Anesth Analg 101:389-95, table of contents. 2005
    ..A preoperative fentanyl challenge used with pharmacokinetic simulations may be a useful tool to individualize the administration of analgesics to chronically opioid-consuming patients...
  41. ncbi Post-tonsillectomy pain management in children: can we do better?
    Jolene D Bean-Lijewski
    Department of Anesthesiology, Scott and White Memorial Hospital, Temple, TX 76508, USA
    Otolaryngol Head Neck Surg 137:545-51. 2007
    ..This study tests the hypothesis that rofecoxib improves pain scores in children for 72 hours post-tonsillectomy when compared to hydrocodone with acetaminophen elixir.
  42. ncbi In-Service
    Keith Wrenn
    Ann Emerg Med 45:675. 2005
  43. ncbi Trials and tribulations: current challenges in conducting clinical trials
    Lillian S Kao
    Department of Surgery, University of Washington, Box 356410, 1959 NE Pacific St, Seattle, WA 98125, USA
    Arch Surg 138:59-62. 2003
    ..This article describes the difficulties encountered at a single institution participating in a multicenter drug study and reviews the challenges involved in developing a high-quality randomized controlled study...
  44. ncbi Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial
    Catherine A Marco
    Acute Care Services, St Vincent Mercy Medical Center, 2213 Cherry Street, Toledo, OH 43608 2591
    Acad Emerg Med 12:282-8. 2005
    Previous studies have demonstrated the efficacy of oxycodone and hydrocodone for the treatment of acute pain...
  45. ncbi When the walls come tumbling down: a pathway to addiction
    Peter N Cannon
    Dentists Concerned for Dentists
    Northwest Dent 84:29-30. 2005
  46. doi Undiagnosed Graves' Disease contributing to sleep disordered breathing in a child undergoing adenotonsillectomy
    Adebisi M Ajala
    Paediatr Anaesth 18:358-9. 2008
  47. ncbi Rational use of analgesic combinations
    James C Phero
    University of Cincinnati Physicians Pain Center, Anesthesia Department, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Post Office Box 670531, Cincinnati, OH 45267 0531, USA
    Dent Clin North Am 46:691-705. 2002
    ..The clinician can and should develop a variety of effective, safe analgesic regimens based on estimates of anticipated pain intensity that apply sound pharmacologic principles...
  48. ncbi Resolution of an oral ulcer secondary to acetaminophen/hydrocodone withdrawal
    Ramesh Balasubramaniam
    Orofacial Pain Center, College of Dentistry and Medicine, University of Kentucky, Lexington, USA
    Gen Dent 55:441-4. 2007
    Acetaminophen/hydrocodone is a common non-opioid/opioid analgesic indicated for the treatment of moderate to severe pain...
  49. ncbi The epidemiologic association between opioid prescribing, non-medical use, and emergency department visits
    Angela M Wisniewski
    University at Buffalo, School of Medicine and Biomedical Sciences Department of Family Medicine, Family Medicine Research Institute, 462 Grider Street, Room CC 191, Buffalo, NY 14215, USA
    J Addict Dis 27:1-11. 2008
    ..Since the 1990s prescriptions for and the non-medical use of opioids have increased. This study examines associations between opioid prescribing, non-medical use, and emergency department (ED) visits...
  50. ncbi Propoxyphene prescribing among populations older and younger than age 65 in a tertiary care hospital
    Sarah Singh
    Lubbock State School, Texas, USA
    Consult Pharm 22:141-8. 2007
    ..To evaluate the proportion of patients aged 65 years and older who are prescribed propoxyphene (PP) versus those aged 65 and younger...
  51. ncbi Internet-based survey of nonmedical prescription opioid use in the United States
    Nathaniel Katz
    Inflexxion Inc, Newton, MA 02464, USA
    Clin J Pain 24:528-35. 2008
    ..An Internet-based survey of nonmedical opioid users visiting informational drug websites was used to measure rates of nonmedical use and characterize users...
  52. ncbi Effect of narcotic pain reliever on pulp tests in women
    Anthony C Kardelis
    Department of Surgical Specialties, University of Nebraska Medical Center College of Dentistry, Lincoln 68583 0757, USA
    J Endod 28:537-9. 2002
    ..Fifteen Caucasian women randomly were given an oral dose of 10 mg of hydrocodone/1000 mg of acetaminophen or placebo in a double-blind, cross-over design...
  53. ncbi Effect of cigarette smoking on serum hydrocodone levels in chronic pain patients
    William E Ackerman
    J Ark Med Soc 104:19-21. 2007
    ..Each group included: I, cigarette smokers; and II, non-smokers. Each patient received 0-40 mg/24hrs of hydrocodone as needed for pain relief for the duration of this four week study...
  54. ncbi The effect of FDA approval of a generic competitor to OxyContin (oxycodone HCl controlled-release) tablets on the abuse of oxycodone
    J Elise Bailey
    Rocky Mountain Poison and Drug Center, Denver Health, CO, USA
    Drug Alcohol Depend 84:182-7. 2006
    ..We evaluated the effect of FDA approval of generic CR oxycodone on the misuse/abuse of oxycodone, hydrocodone, methadone and morphine utilizing data from eight poison control centers (PCC)...
  55. ncbi Relationship between therapeutic use and abuse of opioid analgesics in rural, suburban, and urban locations in the United States
    Theodore J Cicero
    Washington University School of Medicine, MO, USA
    Pharmacoepidemiol Drug Saf 16:827-40. 2007
    ..The goal of these studies was to determine the relationship between prescribed use of opioid analgesics and their non-medically related use (abuse) at a regional level across the country...
  56. ncbi Acetaminophen, aspirin, or Ibuprofen in combination analgesic products
    R L Barkin
    The Rush Pain Center, Rush Presbyterian-St. Luke's Medical Center, 1653 West Congress Parkway, Suite 550, Chicago, IL 60612-3833
    Am J Ther 8:433-42. 2001
    ..Patient-specific cautions are presented for opiate/opioid combinations, codeine, hydrocodone, oxycodone, and propoxyphene, and there is a discussion of COX I/COX II agents.
  57. ncbi The development of a comprehensive risk-management program for prescription opioid analgesics: researched abuse, diversion and addiction-related surveillance (RADARS)
    Theodore J Cicero
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pain Med 8:157-70. 2007
    ..Thus, its major focus was the detection of abuse of OxyContin and other commonly prescribed opioid analgesics at the three-digit ZIP code level across the country utilizing a number of different detection systems...
  58. ncbi Challenges of fragmented care in long-term management of pelvic pain
    Barbara S Apgar
    Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA
    J Fam Pract 56:S20-1. 2007
  59. ncbi Incidence of weak opioids adverse events in the management of cancer pain: a double-blind comparative trial
    Rene Fernando Rodriguez
    Department of Palliative Medicine, Universidad Libre, Calle 59 Norte no 3E63, Paseo de la Flora, Las Acacias Casa 3, Seccional Cali, Cali, Valle, Colombia
    J Palliat Med 10:56-60. 2007
    With the objective of comparing incidence of adverse events of the opioids codeine, hydrocodone, and tramadol in the relief of cancer pain, we conducted a randomized controlled trial in which patients with cancer were randomly assigned ..
  60. ncbi Cognitive and motor function after administration of hydrocodone bitartrate plus ibuprofen, ibuprofen alone, or placebo in healthy subjects with exercise-induced muscle damage: a randomized, repeated-dose, placebo-controlled study
    George J Allen
    Department of Psychology, U 1020, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 166:228-33. 2003
    Medications combining hydrocodone bitartrate and non-steroidal anti-inflammatory agents appear more beneficial than anti-inflammatory medications alone in treating pain and inflammation from acute soft tissue trauma, but opiate side ..
  61. ncbi I am following a health care professional who, I think, has a drug problem
    Gary Carr
    J Miss State Med Assoc 44:10-1. 2003
  62. ncbi The synergistic analgesic interactions between hydrocodone and ibuprofen
    Yuri A Kolesnikov
    Department of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Anesth Analg 97:1721-3. 2003
    ..Using the mouse radiant heat tail-flick nociception model, we observed potent analgesia with hydrocodone. In contrast, ibuprofen as a single drug was inactive in this model of moderate to severe pain, perhaps ..
  63. ncbi Correlates of nonmedical use of hydromorphone and hydrocodone:results from a national household survey
    Meredith Y Smith
    Purdue Pharma L P, One Stamford Forum, Stamford, CT 06901 3431, USA
    J Pain Palliat Care Pharmacother 21:5-17. 2007
    ..use of oral immediate-release hydromorphone (marketed under the brand name of Dilaudid), versus that of hydrocodone combination products using a nationally representative sample of the civilian noninstitutionalized United ..
  64. ncbi Integrating nine prescription opioid analgesics and/or four signal detection systems to summarize statewide prescription drug abuse in the United States in 2007
    Michael F Schneider
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Pharmacoepidemiol Drug Saf 18:778-90. 2009
    ..Integrate statewide rankings of abuse across different drugs and/or signal detection systems to summarize prescription drug abuse in each state in 2007...
  65. ncbi Anticholinergic activity of 107 medications commonly used by older adults
    Marci L Chew
    Department of Pharmaceutical Sciences, School of Pharmacy, Geriatric Psychopharmacology Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 56:1333-41. 2008
    ..celecoxib, cephalexin, diazepam, digoxin, diphenoxylate, donepezil, duloxetine, fentanyl, furosemide, hydrocodone, lansoprazole, levofloxacin, metformin, phenytoin, propoxyphene, and topiramate demonstrated AA only at the ..
  66. ncbi An evaluation of the diagnostic accuracy of liquid chromatography-tandem mass spectrometry versus immunoassay drug testing in pain patients
    Amadeo Pesce
    Millennium Laboratories Research Institute, San Diego, CA 92127, USA
    Pain Physician 13:273-81. 2010
    ..Because clinical use of pain medications is different from illicit drug use, there is a need to evaluate the level of diagnostic accuracy of this procedure for the pain patient...
  67. ncbi A comparative evaluation of the instant-view 5-panel test card with OnTrak TesTcup Pro 5: comparison with gas chromatography-mass spectrometry
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 417 Wakara Way, Suite 2111, Salt Lake City, UT 84108, USA
    J Anal Toxicol 30:50-6. 2006
    ..TesTcup had low cross-reactivity for samples with amphetamine only and hydrocodone and/or hydromorphone; it also had more cross-reactivity towards (i.e., false positives) sympathomimetic amines...
  68. ncbi Effects of selected antihypertensives and analgesics on hepatic porphyrin accumulation: implications for clinical porphyria
    R W Lambrecht
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Biochem Pharmacol 58:887-96. 1999
    ..Among the analgesics tested, fentanyl and tramadol produced the highest porphyrin accumulations. Nalbuphine, hydrocodone, oxycodone, and dezocine were moderately or weakly porphyrogenic, whereas buprenorphine and morphine did not ..
  69. ncbi Comparison of an automated and point-of-care immunoassay to GC-MS for urine oxycodone testing in the clinical laboratory
    Christine A Haller
    Department of Medicine and Laboratory Medicine, University of California San Francisco, Box 1220, San Francisco, CA 94143, USA
    J Anal Toxicol 30:106-11. 2006
    ..The POC assay had two false positives and 15 indeterminate (+/-) results. Codeine or hydrocodone was present in all but one of these samples...
  70. ncbi Identification and quantitation of amphetamines, cocaine, opiates, and phencyclidine in oral fluid by liquid chromatography-tandem mass spectrometry
    Dean Fritch
    OraSure Technologies, Research and Development, Bethlehem, Pennsylvania 18015, USA
    J Anal Toxicol 33:569-77. 2009
    ..pseudoephedrine, cocaine, benzoylecgonine, codeine, norcodeine, 6-acetylcodeine, morphine, 6-acetylmorphine, hydrocodone, norhydrocodone, dihydrocodeine, hydromorphone, oxycodone, noroxycodone, oxymorphone, and phencyclidine...
  71. ncbi Evidence of morphine metabolism to hydromorphone in pain patients chronically treated with morphine
    Edward J Cone
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Anal Toxicol 30:1-5. 2006
    Minor metabolic pathways in human subjects have been shown to exist for the conversion of codeine to hydrocodone but have not been reported for the metabolic conversion of morphine to hydromorphone...
  72. ncbi Gateways to clinical trials
    M Bayes
    Methods Find Exp Clin Pharmacol 24:371-91. 2002
    ..FTY-720, fulvestrant; Gabapentin, galantamine hydrobromide, ganciclovir, gemcitabine, glatiramer acetate; Hydrocodone bitartrate; Interferon beta, interferon beta-1a, interferon beta-1b, ipratropium bromide; Ketotifen; Lamivudine,..
  73. ncbi Chronic traumatic encephalopathy in a professional American wrestler
    Bennet I Omalu
    San Joaquin General Hospital, French Camp, California, USA
    J Forensic Nurs 6:130-6. 2010
    ..ventricular hypertrophy, and bilateral atrioventricular dilatation; toxicologic analyses showed alprazolam and hydrocodone in the blood, and evidence of exogenous testosterone in the urine...
  74. pmc Purification and characterization of morphinone reductase from Pseudomonas putida M10
    C E French
    Institute of Biotechnology, University of Cambridge, U K
    Biochem J 301:97-103. 1994
    ..reductase from Pseudomonas putida M10 catalyses the reduction of morphinone and codeinone to hydromorphone and hydrocodone respectively...
  75. pmc Bactrian ("double hump") acetaminophen pharmacokinetics: a case series and review of the literature
    Robert G Hendrickson
    Oregon Poison Center, Portland, OR 97210, USA
    J Med Toxicol 6:337-44. 2010
    ..A 38-year-old woman ingested 2 g hydrocodone/65 g acetaminophen...
  76. ncbi Urine drug testing of chronic pain patients. II. Prevalence patterns of prescription opiates and metabolites
    Rebecca Heltsley
    Aegis Sciences Corporation, 515 Great Circle Road, Nashville, Tennessee, USA
    J Anal Toxicol 34:32-8. 2010
    ..by LC-MS-MS [limit of quantitation (LOQ) = 50 ng/mL] for 10 opiate analytes (codeine, norcodeine, morphine, hydrocodone, dihydrocodeine, norhydrocodone, hydromorphone, oxycodone, noroxycodone, and oxymorphone)...
  77. ncbi Effects of the NOP receptor agonist Ro65-6570 on the acquisition of opiate- and psychostimulant-induced conditioned place preference in rats
    Kris Rutten
    Grunenthal GmbH, Global Preclinical Research and Development, Department of Pharmacology, Zieglerstrasse 6, 52078 Aachen, Germany
    Eur J Pharmacol 645:119-26. 2010
    ..1-3.16 mg/kg i.p.), morphine (1-10mg/kg i.p.), hydrocodone (0.316-10mg/kg i.p.), tilidine (1-31.6 mg/kg i.p.), hydromorphone (0.1-10mg/kg i.p.), and oxycodone (0...
  78. ncbi Simultaneous quantitation of opioids in blood by GC-EI-MS analysis following deproteination, detautomerization of keto analytes, solid-phase extraction, and trimethylsilyl derivatization
    Jeri D Ropero-Miller
    Office of the Chief Medical Examiner, Chapel Hill, North Carolina 27599, USA
    J Anal Toxicol 26:524-8. 2002
    Seven opioid analytes including codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone were detected in postmortem blood (n > 1000)...
  79. ncbi Detecting signals of opioid analgesic abuse: application of a spatial mixed effect poisson regression model using data from a network of poison control centers
    Meredith Y Smith
    Purdue Pharma LP, Stamford, CT, USA
    Pharmacoepidemiol Drug Saf 17:1050-9. 2008
    ..To assist pharmacovigilance efforts, we developed a methodology for detecting geo-specific "signals" of potential outbreaks of prescription drug abuse by 3-digit ZIP (3DZ) code...
  80. ncbi Simultaneous analysis of thebaine, 6-MAM and six abused opiates in postmortem fluids and tissues using Zymark automated solid-phase extraction and gas chromatography-mass spectrometry
    R J Lewis
    Civil Aerospace Medical Institute, Federal Aviation Administration, Forensic Toxicology Research Laboratory, AAM 610, P O Box 25082, Oklahoma City, OK 73125, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 822:137-45. 2005
    ..These compounds are hydrocodone, dihydrocodeine, codeine, oxycodone, hydromorphone, 6-monoacetylmorphine, morphine, and thebaine...
  81. ncbi Evaluation of the usefulness of an oxycodone immunoassay in combination with a traditional opiate immunoassay for the screening of opiates in urine
    Marie Gingras
    Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
    J Anal Toxicol 34:78-83. 2010
    ..The GC-MS allowed us to detect codeine, hydrocodone, hydromorphone, morphine, oxycodone, and oxymorphone following enzymatic hydrolysis and derivation by ..
  82. ncbi Opioid toxicity recurrence after an initial response to naloxone
    W A Watson
    University of Missouri Kansas City Truman Medical Center, 64108, USA
    J Toxicol Clin Toxicol 36:11-7. 1998
    ..To determine the frequency and potential predictors of opioid toxicity recurrence after a response to naloxone in adult Emergency Department patients...
  83. ncbi Hair analysis for opiates: evaluation of washing and incubation procedures
    M A Balíková
    First Faculty of Medicine, Institute of Forensic Medicine and Toxicology, Charles University in Prague, Katerinska 32, 121 08 2, Prague, Czech Republic
    J Chromatogr B Analyt Technol Biomed Life Sci 789:93-100. 2003
    ..of the hair matrix were evaluated and the relative recoveries for morphine, codeine, dihydrocodeine and hydrocodone were compared...
  84. ncbi Determination of illicit drugs and related substances by high-performance liquid chromatography with an electrochemical coulometric-array detector
    G Achilli
    EuroService srl, Parabiago, Italy
    J Chromatogr A 729:273-7. 1996
    ..3,4-methylenedioxymetamphetamine, buprenorphin, cocaine, codeine, dihydrocodeine, ethylmorphine, heroin, hydrocodone, lidocaine, methadone, morphine, naloxone, procaine and thebaine) was developed using reversed-phase HPLC and ..
  85. ncbi Analgesics for acute pain: Meeting the United States Food and Drug Administration's requirements for proof of efficacy
    Derry Ridgway
    Lineberry Research Associates, Research Triangle Park, NC, USA
    Clin J Pain 20:123-32. 2004
    ..To examine the United States Food and Drug Administration's (FDA) standards for reviews of the scientific basis for efficacy claims for newly approved oral analgesics...
  86. ncbi Utilization of pharmacogenomics and therapeutic drug monitoring for opioid pain management
    Paul J Jannetto
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, WI 53226, USA
    Pharmacogenomics 10:1157-67. 2009
    ....
  87. ncbi Prescription opioid use in the rural Appalachia: a community-based study
    Jennifer R Havens
    Center on Drug and Alcohol Research, University of Kentucky College of Medicine, Lexington, KY, USA
    J Opioid Manag 4:63-71. 2008
    ..The purpose of this study is to describe the sample characteristics and methods for a study of rural medical and nonmedical prescription opioid users with a history of OxyContin use...
  88. ncbi Costs of gastrointestinal events after outpatient opioid treatment for non-cancer pain
    Winghan Jacqueline Kwong
    Johnson and Johnson Pharmaceutical Services, LLC, Raritan, NJ, USA
    Ann Pharmacother 44:630-40. 2010
    ..Gastrointestinal (GI) adverse effects are common with oral opioid treatment...
  89. ncbi Epidemiological trends in abuse and misuse of prescription opioids
    Henry Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    J Addict Dis 28:130-6. 2009
    ..social, geographic, and demographic factors and cases of select scheduled drugs (buprenorphine, fentanyl, hydrocodone, hydromorphone, morphine, methadone, and oxycodone) using the Researched Abuse, Diversion and Addiction-Related ..
  90. ncbi GC-MS analysis of multiply derivatized opioids in urine
    Bud Gen Chen
    Department of Medical Technology, Fooyin University, Kaohsiung Hsien 831 02, Taiwan
    J Mass Spectrom 42:1012-23. 2007
    Opiates such as hydrocodone, hydromorphone, oxycodone, noroxycodone, and oxymorphone reportedly may interfere with the analysis of morphine and codeine. The analysis of these compounds themselves also is an important issue...
  91. ncbi Treatment of the common cold
    Madeline Simasek
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am Fam Physician 75:515-20. 2007
    ..Codeine has not been shown to effectively treat cough caused by the common cold. Although hydrocodone is widely used and has been shown to effectively treat cough caused by other conditions, the drug has not been ..
  92. ncbi Therapeutic use, abuse, and nonmedical use of opioids: a ten-year perspective
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 13:401-35. 2010
    ..6% of the world's population, have been consuming 80% of the global opioid supply, and 99% of the global hydrocodone supply, as well as two-thirds of the world's illegal drugs...
  93. ncbi Relationship of unemployment rate and rate of opiate exposure in Kentucky
    Diana J Gascon
    The Permanente Medical Group, Inc, USA
    J Psychoactive Drugs 41:99-102. 2009
    ..Opioid analgesic abuse, particularly with Oxycontin and hydrocodone, has increased in the past years...
  94. ncbi Carisoprodol withdrawal syndrome
    Roy R Reeves
    G V Sonny Montgomery VA Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA
    Pharmacotherapy 24:1804-6. 2004
    A 43-year-old man with chronic back and shoulder pain was treated with hydrocodone. He began taking excessive amounts of the drug, so his physicians stopped prescribing it...
  95. ncbi Rhabdomyolysis associated with the nutritional supplement Hydroxycut
    Sarah Dehoney
    Department of Pharmacy Services, University of Utah, Salt Lake City, UT 84132, USA
    Am J Health Syst Pharm 66:142-8. 2009
    ..A case of rhabdomyolysis associated with the use of Hydroxycut is reported...
  96. ncbi Persistent nonmalignant pain and analgesic prescribing patterns in elderly nursing home residents
    Aida B Won
    Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 02131, USA
    J Am Geriatr Soc 52:867-74. 2004
    ..To determine the prevalence of analgesics used, their prescribing patterns, and associations with particular diagnoses and medications in patients with persistent pain...
  97. ncbi Weak analgesics and nonsteroidal anti-inflammatory agents in the management of children with acute pain
    J D Tobias
    Department of Pediatrics, University of Missouri, Columbia, USA
    Pediatr Clin North Am 47:527-43. 2000
    ..pain, the NSAID salicylate or acetaminophen can be combined with a weak opioid, such as codeine, oxycodone, or hydrocodone. When using oral analgesics, factors that may interfere with effective analgesia include a child's refusal to ..
  98. ncbi Prevalence of side effects of prolonged low or moderate dose opioid therapy with concomitant benzodiazepine and/or antidepressant therapy in chronic non-cancer pain
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 12:259-67. 2009
    ..However, there is no data available on the prevalence of side effects associated with low or moderate dose opioid use in chronic non-cancer pain when administered in conjunction with interventional techniques...
  99. ncbi Septic sternoclavicular joint: a case report
    Ralph A Crisostomo
    Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 89:884-6. 2008
    ..After discontinuation of prednisone and hydrocodone-acetaminophen that he had been receiving, the patient became febrile...
  100. ncbi Quantifying morbidity associated with the abuse and misuse of opioid analgesics: a comparison of two approaches
    Meredith Y Smith
    Purdue Pharma L P, One Stamford Forum, Stamford, Connecticut 06901 3431, USA
    Clin Toxicol (Phila) 45:23-30. 2007
    ..Due to the rising nonmedical use of opioid analgesics, methods are needed to quantify the associated health-related consequences...
  101. ncbi Acetaminophen ototoxicity after acetaminophen/hydrocodone abuse: evidence from two parallel in vitro mouse models
    Joshua G Yorgason
    Division of Otolaryngology, University of Utah, Salt Lake City, UT, USA
    Otolaryngol Head Neck Surg 142:814-9, 819.e1-2. 2010
    Acetaminophen/hydrocodone, a commonly used analgesic preparation, has been linked to rapidly progressing sensorineural hearing loss in human patients...

Research Grants43

  1. Licit &Illicit Opioids: Comparative Studies in Humans
    Sharon L Walsh; Fiscal Year: 2013
    ..epidemic by conducting a series of studies on the clinical pharmacology of the most widely abused opioids (hydrocodone, oxycodone and Oxycontin(R))...
  2. The Prescriber Opioid Risk Reduction Strategies (PORRS) Study
    Jeanine K Mount; Fiscal Year: 2013
    ..Opioids of greatest concern (e.g., oxycodone, hydrocodone, methadone, morphine, codeine) are found in single- entity and combination drug products categorized as ..
  3. Characterization of the Role of mTOR Signaling in Opiate Action
    MICHELLE SUZANNE MAZEI ROBISON; Fiscal Year: 2010
    ..Given that the most highly prescribed drug in the U.S. in 2005 was an opiate, hydrocodone with acetaminophen, and that the non-prescription use has also increased, especially in adolescents where use ..
  4. 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Phy
    LAWRENCE F CHU; Fiscal Year: 2013
    ..1 Currently, opioids are among the most common medications prescribed by physicians in the US2 and Vicodin (hydrocodone/acetaminophen) -- with 100 million prescriptions in 2005 alone -- is the most commonly prescribed medication of ..
  5. The effects of acetaminophen on the rewarding properties of hydrocodone in rats
    Arbi Nazarian; Fiscal Year: 2010
    ..However, many prescription opioid analgesics contain a combination of two compounds: an opioid agonist, such as hydrocodone, plus a non-narcotic analgesic, such as acetaminophen...
  6. BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERS
    James Zacny; Fiscal Year: 2003
    ..studies in normal volunteers, focusing on four oral drugs commonly used in outpatient settings: hydrocodone, oxycodone, propoxyphene, and tramadol...
  7. Understanding the Effects of Chronic Opioids Therapy in Humans
    LAWRENCE F CHU; Fiscal Year: 2013
    ..Currently, opioids are among the most common medications prescribed by physicians in the US and Vicodin (hydrocodone/acetaminophen) is the most prescribed medication of any category...
  8. Novel drug combinations for the management of pain
    KENNETH NARDUCY; Fiscal Year: 2007
    ..Combinations of acetaminophen with opioids (i.e., hydrocodone, codeine) are frequently prescribed for acute and chronic pain management...
  9. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
    ..Profound bilateral deafness requiring cochlear implantation secondary to chronic high dose use of acetaminophen/hydrocodone has been reported by our Neurotology Clinic...
  10. Development of SCP-1/opioid combinations for pain
    KENNETH NARDUCY; Fiscal Year: 2003
    Combinations of acetaminophen with opioids (i.e., hydrocodone, codeine) are frequently prescribed for acute and chronic pain management...
  11. OPIATE ENDOCRINE INTERACTIONS--DEVELOPMENTAL ASPECTS
    THEODORE CICERO; Fiscal Year: 2003
    ..The proposed animal studies could establish whether gender differences exist and if these differences are based on inherent, first-order biological differences between the sexes. ..
  12. Molecular Genetics of Inattention in Australia
    THEODORE CICERO; Fiscal Year: 2009
    ..This will be at a marked cost savings due to the employment of existing well-characterized samples and the long history of collaborative studies between investigators from Australia and the United States. ..
  13. Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain Patients
    James P Zacny; Fiscal Year: 2010
    ..g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients. ..
  14. CHARACTERIZING PSYCHOACTIVE EFFECTS OF INHALANTS
    James Zacny; Fiscal Year: 2004
    ..In short, in our two proposed series of studies, we are developing a human laboratory model of inhalant abuse by studying potential determinants of abuse liability of inhalants (volatile and gaseous) in healthy volunteers. ..
  15. BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERS
    James Zacny; Fiscal Year: 2009
    ..doses of different opioids within the same study and within the same individual (Study 1: oxycodone versus hydrocodone;Study 2: oxycodone versus morphine)...
  16. Screening and Brief Advice to Reduce Teen Substance Use
    John Knight; Fiscal Year: 2008
    ..An effective brief intervention could be widely implemented in primary care practices that serve adolescents, and would be of enormous public health significance across the U.S. ..
  17. Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial
    Sharon Walsh; Fiscal Year: 2008
    ..This study will provide preliminary safety and efficacy data on the potential utility of atomoxetine and determine whether a larger-scale evaluation is warranted. [unreadable] [unreadable] [unreadable]..
  18. Clinical Research Training in Geriatric Mood Disorders
    Dan Blazer; Fiscal Year: 2008
    ..Students will be paired with a single mentor who will guide them in undertaking a focused research project. Findings will be presented at a National meeting. ..
  19. Evaluation of Novel Treatments for Stimulant Dependence
    Sharon Walsh; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  20. Long-term Opioid Management of Chronic Pain: Trends and Risks
    Michael Von Korff; Fiscal Year: 2009
    ..We will extend these analyses by studying the effects of long-term opioid therapy on other adverse events including: all-cause and opioid-related hospitalization;opioid overdose;and onset of recognized mood disorder. ..
  21. Neuropharmacology of Tramadol: Clinical Efficacy and Abuse Potential
    WILLIAM WALTON STOOPS; Fiscal Year: 2010
    ..Developing analgesics with reduced abuse potential may reduce the prevalence of prescription opioid misuse and subsequent opioid use disorders. ..
  22. Understanding the Scope and Magnitude of Prescription Drug Diversion
    Steven P Kurtz; Fiscal Year: 2010
    ....
  23. New Neural Targets for Opioid Use Disorders: Human Studies
    Sharon L Walsh; Fiscal Year: 2010
    ..Thus, these studies, conducted in healthy humans, will provide fundamental information regarding the potential for this system as a target for development of new treatment agents for opioid use disorders. ..
  24. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2003
    ..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
  25. Academic Career Award in Adolescent Alcohol Abuse
    John Knight; Fiscal Year: 2008
    ..Dr. Knight's background in teaching and training, and established relationships with national organizations, will help ensure the widest possible dissemination of his research findings. ..
  26. Depression-Diabetes Care Disparities, Adverse Outcomes
    Michael Von Korff; Fiscal Year: 2008
    ..Aim 3: Set priorities for integrated services - We will assess criteria relevant to priorities for integrated management of diabetes, depression and associated behavioral risk factors. [unreadable] [unreadable]..
  27. APOE QUALITY OF LIFE AND MEDICAL COSTS IN LATE LIFE
    Dan Blazer; Fiscal Year: 2002
    ..Cox proportional hazard, discrete time survival, and hierarchical linear modeling will be used according to the metric and distribution of the dependent variable. ..
  28. Microbiology/Immunology of Periodontal Disease in T1DM
    Paul Moore; Fiscal Year: 2002
    ..An integrated multidisciplinary effort provides significant data collection capabilities essential for understanding the complex multifactorial etiology of periodontal disease in Type 1 diabetes. ..
  29. Antidepressant Use by Older Adults
    Dan Blazer; Fiscal Year: 2003
    ..We will also test hypotheses specific to individual domains in the larger model. ..
  30. COCAINE DEPENDENCE & PTSD: THE ROLE OF STRESS REACTIVITY
    SUDIE BACK; Fiscal Year: 2003
    ..Careful study of the mechanistic link between stress, PTSD and cocaine dependence will inform existing theoretical models and may improve prevention and intervention efforts for this challenging patient population. ..
  31. PHARMACOLOGY OF COMBINED EPHEDRINE/CAFFEINE SUPPLEMENTS
    Christine Haller; Fiscal Year: 2004
    ..The long-term objective for the proposed studies is to develop Dr. Haller into an independent career clinical researcher in this field of study. ..
  32. IDENTIFYING ADOLESCENT ALCOHOL USE IN THE MEDICAL OFFICE
    John Knight; Fiscal Year: 2001
    ..The results of this study will ultimately lead to the development and testing of a physician's guide to helping adolescent patients with alcohol/drug problems. ..
  33. Treatment of Fear and Pain in Irritable Bowel Syndrome
    Bruce Naliboff; Fiscal Year: 2006
    ..abstract_text> ..
  34. Integrated Care for Depression and Chronic Back Pain
    Michael Von Korff; Fiscal Year: 2006
    ..abstract_text> ..
  35. Medical Office Intervention for Adolescent Drug Use
    John Knight; Fiscal Year: 2008
    ..An effective brief intervention for drug abuse could be widely implemented in settings where adolescents receive routine healthcare, and would be of enormous public health significance across the U.S. ..
  36. Sublingual Buprenorphine for Chronic Pain in Patients at Risk for Drug Abuse
    Andrew Rosenblum; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. FURANOCOUMARINS AND DRUGS EFFECT ON CYP3A4
    Paul Watkins; Fiscal Year: 2007
    ..abstract_text> ..
  38. Hyperalgesia in Methadone Patients: Can it be Treated?
    Margaret Compton; Fiscal Year: 2007
    ..abstract_text> ..
  39. Social Role Disability and Mental-Physical Co-Morbidity
    Michael Von Korff; Fiscal Year: 2007
    ..abstract_text> ..
  40. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2006
    ..abstract_text> ..
  41. Factors in Drug Dependence
    Sharon Walsh; Fiscal Year: 2005
    ..abstract_text> ..
  42. THERAPEUTIC POTENTIAL OF KAPPA-OPIOIDS AGAINST COCAINE
    Sharon Walsh; Fiscal Year: 2002
    ..These studies are relevant to the treatment of cocaine abuse and may lead to the development of an effective pharmacotherapy, thereby, reducing the HIV and other health risks associated with cocaine abuse and intravenous drug abuse. ..
  43. PREVENTION FOR AT-RISK MEN: A MIXED SEROSTATUS APPROACH
    Steven Kurtz; Fiscal Year: 2006
    ..unreadable] [unreadable]..