morphine

Summary

Summary: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

Top Publications

  1. pmc Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance
    Yeong Ray Wen
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Formos Med Assoc 110:487-94. 2011
  2. ncbi Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis
    Francesco Ferrini
    Institut universitaire en santé mentale de Québec, Quebec, Canada
    Nat Neurosci 16:183-92. 2013
  3. ncbi Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment in rodents
    Su Liu
    Department of Neurobiology, Parker University Research Institute, Dallas, Texas 75229, USA
    Cancer Res 71:4392-402. 2011
  4. pmc Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
    Gregory Scherrer
    Department of Anatomy and Physiology and WM Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, USA
    Cell 137:1148-59. 2009
  5. pmc BDNF is a negative modulator of morphine action
    Ja Wook Koo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 338:124-8. 2012
  6. ncbi Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth
    Kalpna Gupta
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Cancer Res 62:4491-8. 2002
  7. ncbi Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects
    Yuri Kolesnikov
    East Tallinn Central Hospital, Parnu mnt, 104, Tallinn, 11312, Estonia
    Anesth Analg 112:448-53. 2011
  8. ncbi Morphine, gabapentin, or their combination for neuropathic pain
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ont, Canada
    N Engl J Med 352:1324-34. 2005
  9. ncbi An essential role for DeltaFosB in the nucleus accumbens in morphine action
    Venetia Zachariou
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 9:205-11. 2006
  10. pmc Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University School of Medicine, Campus de Espinardo, 30100 Murcia, Spain
    Endocrinology 150:3118-27. 2009

Detail Information

Publications347 found, 100 shown here

  1. pmc Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance
    Yeong Ray Wen
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Formos Med Assoc 110:487-94. 2011
    ..Inhibition of spinal cord p38 has been shown to attenuate neuropathic and postoperative pain, as well as morphine-induced antinociceptive tolerance...
  2. ncbi Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis
    Francesco Ferrini
    Institut universitaire en santé mentale de Québec, Quebec, Canada
    Nat Neurosci 16:183-92. 2013
    A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates...
  3. ncbi Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment in rodents
    Su Liu
    Department of Neurobiology, Parker University Research Institute, Dallas, Texas 75229, USA
    Cancer Res 71:4392-402. 2011
    ..that EphB1 receptor forward signaling in the spinal cord is critical to the development of bone cancer pain and morphine tolerance in treating bone cancer pain...
  4. pmc Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
    Gregory Scherrer
    Department of Anatomy and Physiology and WM Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, USA
    Cell 137:1148-59. 2009
    ..These results demonstrate that behaviorally relevant pain modalities can be selectively regulated through the targeting of distinct subsets of primary afferent pain fibers...
  5. pmc BDNF is a negative modulator of morphine action
    Ja Wook Koo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 338:124-8. 2012
    ..We discovered a surprising opposite role for BDNF in countering responses to chronic morphine exposure...
  6. ncbi Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth
    Kalpna Gupta
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Cancer Res 62:4491-8. 2002
    b>Morphine is used to treat pain in several medical conditions including cancer...
  7. ncbi Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects
    Yuri Kolesnikov
    East Tallinn Central Hospital, Parnu mnt, 104, Tallinn, 11312, Estonia
    Anesth Analg 112:448-53. 2011
    ..have generated controversial results regarding the influence of the genetic variations of μ-opioid receptors on morphine analgesia and opioid-related side effects in the postoperative period...
  8. ncbi Morphine, gabapentin, or their combination for neuropathic pain
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ont, Canada
    N Engl J Med 352:1324-34. 2005
    ..We compared the efficacy of a combination of gabapentin and morphine with that of each as a single agent in patients with painful diabetic neuropathy or postherpetic neuralgia.
  9. ncbi An essential role for DeltaFosB in the nucleus accumbens in morphine action
    Venetia Zachariou
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 9:205-11. 2006
    ..DeltaFosB overexpression in the NAc increased the sensitivity of the mice to the rewarding effects of morphine and led to exacerbated physical dependence, but also reduced their sensitivity to the analgesic effects of ..
  10. pmc Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University School of Medicine, Campus de Espinardo, 30100 Murcia, Spain
    Endocrinology 150:3118-27. 2009
    ..Enhanced responsiveness of the hypothalamo-pituitary-adrenal axis after morphine withdrawal has been associated with hyperactivity of ascending noradrenergic input from the nucleus of the ..
  11. ncbi Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain
    Joanna Mika
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Cracow, Poland
    Eur J Pharmacol 560:142-9. 2007
    ..Antiallodynic and antihyperalgesic effect of morphine (10 mg/kg; i.p...
  12. pmc Morphine activates neuroinflammation in a manner parallel to endotoxin
    Xiaohui Wang
    Department of Chemistry and Biochemistry, Center for Neuroscience, and Biofrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 109:6325-30. 2012
    ..Herein, we provide direct evidence that morphine creates neuroinflammation via the activation of an innate immune receptor and not via classic opioid receptors...
  13. pmc Distinct patterns of DeltaFosB induction in brain by drugs of abuse
    L I Perrotti
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Synapse 62:358-69. 2008
    ..We also extended previous research involving cocaine, morphine, and nicotine to two additional drugs of abuse, ethanol and Delta(9)-tetrahydrocannabinol (Delta(9)-THC, the ..
  14. pmc Morphine regulates dopaminergic neuron differentiation via miR-133b
    Fátima Macho Sánchez-Simón
    Department of Biochemistry and Molecular Biology, Institute of Neuroscience, University of Salamanca, Salamanca, Spain
    Mol Pharmacol 78:935-42. 2010
    b>Morphine is one of the analgesics used most to treat chronic pain, although its long-term administration produces tolerance and dependence through neuronal plasticity...
  15. ncbi The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery
    Shahbaz R Arain
    Department of Anesthesiology, Medical College of Wisconsin and VA Medical Center, 5000 W National Avenue, Milwaukee, WI 53295, USA
    Anesth Analg 98:153-8, table of contents. 2004
    ..4 microg. kg(-1). h(-1) for 4 h) or morphine sulfate (0.08 mg/kg) 30 min before the end of surgery...
  16. pmc Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain
    Christian Zöllner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Clin Invest 118:1065-73. 2008
    ..Here we show that rats with chronic morphine treatment do not develop signs of tolerance at peripheral mu-opioid receptors (micro-receptors) in the presence ..
  17. ncbi The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease
    P Klepstad
    Institute of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Acta Anaesthesiol Scand 48:1232-9. 2004
    Dispositions for genes encoding opioid receptors may explain some variability in morphine efficacy...
  18. ncbi Enhanced morphine analgesia in mice lacking beta-arrestin 2
    L M Bohn
    Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 286:2495-8. 1999
    The ability of morphine to alleviate pain is mediated through a heterotrimeric guanine nucleotide binding protein (G protein)-coupled heptahelical receptor (GPCR), the mu opioid receptor (muOR)...
  19. ncbi Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials
    Grégoire Blaudszun
    Division of Anesthesiology, Geneva University Hospitals, Geneva, Switzerland
    Anesthesiology 116:1312-22. 2012
    ..Systemic α2 agonists are believed to reduce pain and opioid requirements after surgery, thus decreasing the incidence of opioid-related adverse effects, including hyperalgesia...
  20. ncbi In heterozygous GDNF knockout mice the response of striatal dopaminergic system to acute morphine is altered
    Mikko Airavaara
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, FIN 00014, Finland
    Synapse 59:321-9. 2006
    ..To study whether reduced endogenous GDNF affect morphine's effects on striatal dopamine transmission, we estimated extracellular concentrations of dopamine and its ..
  21. pmc Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction
    G Hu
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 3:e381. 2012
    ..Opiates such as morphine have been shown to enhance HIV transactivation protein Tat-mediated toxicity in both human neurons and ..
  22. ncbi Effects of selective and non-selective inhibitors of nitric oxide synthase on morphine- and endomorphin-1-induced analgesia in acute and neuropathic pain in rats
    Wioletta Makuch
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Neuropharmacology 75:445-57. 2013
    ..t.) administered nitric oxide synthase (NOS) inhibitors on the antinociceptive effects of morphine and endomorphin-1 during acute pain and in chronic constriction injury (CCI)-exposed rats...
  23. ncbi Morphine, oxycodone, and fentanyl exhibit different analgesic profiles in mouse pain models
    Kazuhisa Minami
    Pain and Neurology, Discovery Research Laboratories, Shionogi and Co, Ltd, Japan
    J Pharmacol Sci 111:60-72. 2009
    b>Morphine, oxycodone, and fentanyl are clinically prescribed drugs for the management of severe pain. We investigated whether these opioids possess different efficacy profiles on several types of pain in mouse pain models...
  24. ncbi Loss of peripheral morphine analgesia contributes to the reduced effectiveness of systemic morphine in neuropathic pain
    Md Harunor Rashid
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 309:380-7. 2004
    It is well known that the analgesic potency of morphine is reduced in neuropathic pain...
  25. ncbi Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain
    Lasse Dührsen
    Department of Neonatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neonatology 103:35-43. 2013
    ..Untreated exposure to pain in preterm neonates might damage the vulnerable premature brain and alter development. Pain treatment is limited because analgesic agents may also have adverse neurodevelopmental consequences in newborns...
  26. ncbi Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain
    Maria Osikowicz
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Pain 139:117-26. 2008
    ..Moreover, single administration of MPEP (30 mg/kg; i.p.) or LY379268 (10mg/kg; i.p.) injected 30 min before morphine potentiated morphine's effects (20mg/kg; i.p...
  27. pmc Morphine tolerance in the mouse ileum and colon
    Gracious R Ross
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 327:561-72. 2008
    Repeated administration of morphine is associated with tolerance to its antinociceptive properties. However, constipation remains the major side effect of chronic exposure to morphine...
  28. ncbi Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses
    Ju Wang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Mol Neurobiol 44:269-86. 2011
    ..or human brain tissues after the administration of alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine/heroin/butorphanol, or nicotine...
  29. pmc Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions
    D J Mayer
    Department of Anesthesiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 96:7731-6. 1999
    ..Similar cellular mechanisms also have been implicated in the development of tolerance to the analgesic effects of morphine. A recently observed phenomenon, the development of "dark neurons," is associated with both chronic constriction ..
  30. pmc Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection
    Jing Ma
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Infect Immun 78:830-7. 2010
    ..pneumoniae lung infection, we explored the influence of morphine treatment on the interleukin-23 (IL-23)/IL-17 axis and related innate immunity...
  31. ncbi Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain
    Ilona Obara
    Department of Pain Pharmacology, Institute of Pharmacology PAS, Smetna 12, 31 343 Krakow, Poland
    Pain 141:283-91. 2009
    ..The obtained results differentiate inflammatory and neuropathic pain and provide a novel insight into the peripheral effectiveness of opioids in both types of pain...
  32. pmc Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration
    Trissa Babrowski
    Center of Surgical Infection Research and Therapeutics, Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Ann Surg 255:386-93. 2012
    This study was designed to examine the effect of morphine administration on the intestinal mucus barrier and determine its direct effect on the virulence and lethality of Pseudomonas aeruginosa, one of the most frequent pathogens to ..
  33. ncbi Effects of maternal oral administration of morphine sulfate on developing rat fetal cerebrum: a morphometrical evaluation
    Seyed Homayoon Sadraie
    Applied Neuroscience Research Center, Neurobiology Research Division, Baqiyatallah University of Medical Sciences, Iran
    Brain Res 1245:36-40. 2008
    Intrauterine morphine exposure is a risk factor for neurological and behavioral deficit in children, although the precise underlying biological correlate for this is unclear. Female pregnant rats were orally treated with 0...
  34. pmc Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils
    Elise Glattard
    INSERM, U575, Physiopathologie du Système Nerveux and Nociception and Pain Department, Institut des Neurosciences Cellulaires et Integratives, Centre National de la Recherche Scientifique, Universite de Strasbourg, Strasbourg, France
    PLoS ONE 5:e8791. 2010
    Mammalian cells synthesize morphine and the respective biosynthetic pathway has been elucidated. Human neutrophils release this alkaloid into the media after exposure to morphine precursors...
  35. ncbi Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Ann N Y Acad Sci 1141:96-104. 2008
    ..In vitro treatment of cortical neuron/glia cocultures with either methamphetamine or morphine caused activation of astrocytes via protein kinase C (PKC)...
  36. pmc Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability
    Hui Zheng
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455 0217, USA
    J Neurosci 30:8102-10. 2010
    ..NeuroD level by reducing the amount of microRNA-190 (miR-190), an inhibitor of NeuroD expression, whereas morphine does not alter NeuroD level...
  37. ncbi Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice
    Hossein Hosseinzadeh
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 24:726-30. 2010
    ..Thus, the effects of aqueous and ethanolic extracts of stigma and its constituents were evaluated on morphine-withdrawal syndrome in mice. Dependence was induced using subcutaneous (s.c.) injections of morphine for 3 days...
  38. pmc Morphine treatment of human monocyte-derived macrophages induces differential miRNA and protein expression: impact on inflammation and oxidative stress in the central nervous system
    Rajnish S Dave
    Center for Neurovirology, Department of Neuroscience, Temple University, MERB 774A, 3500 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    J Cell Biochem 110:834-45. 2010
    ..In order to understand the role of morphine in this process, we performed a genome-wide association study at the micro RNA (miRNA) and protein levels in ..
  39. ncbi A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia
    Yu Cui
    Department of Physiology, Zhongshan Medical College, Sun Yat Sen University, Guangzhou 510080, PR China
    Brain Behav Immun 22:114-23. 2008
    ..demonstrated that activation of p38 mitogen-activated protein kinase (p38 MAPK) in the spinal microglia mediates morphine antinociceptive tolerance...
  40. ncbi Morphine glucuronidation in preterm neonates, infants and children younger than 3 years
    Catherijne A J Knibbe
    Department of Clinical Pharmacy, St Antonius Hospital, 3430 EM Nieuwegein, The Netherlands
    Clin Pharmacokinet 48:371-85. 2009
    ..to derive rational dosing schemes, the influence of aging on glucuronidation capacity in newborns, including preterms, infants and children under the age of 3 years was studied using morphine and its major metabolites as a model drug.
  41. ncbi Morphine stimulates vascular endothelial growth factor-like signaling in mouse retinal endothelial cells
    Chunsheng Chen
    Vascular Biology Center, Division of Hematology, Oncology and Transplantation, University of Minnesota Medical School, Mayo Mail Code 480, Minneapolis, Minnesota 55455, USA
    Curr Neurovasc Res 3:171-80. 2006
    ..receptor (MOR) transactivates Flk1 and platelet-derived growth factor-beta (PDGF-beta) receptors and its agonist morphine stimulates pro-angiogenic and survival-promoting signaling in mouse retinal endothelial cells (mREC)...
  42. pmc Morphine enhances Tat-induced activation in murine microglia
    Sirosh M Bokhari
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurovirol 15:219-28. 2009
    ..In the current study, we explored the effects of morphine and HIV-1 Tat(1-72) on the activation of mouse BV-2 microglial cells and primary mouse microglia...
  43. ncbi Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    J Neurosci 26:398-405. 2006
    ..the role of orexinergic systems in dopamine-related behaviors induced by the mu-opioid receptor agonist morphine in rodents...
  44. ncbi Morphine exacerbates HIV-1 viral protein gp120 induced modulation of chemokine gene expression in U373 astrocytoma cells
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, Kaleida Health, 100 High Street, Buffalo, NY 14203, USA
    Curr HIV Res 3:277-88. 2005
    ..Herein we describe the effects of morphine and/or gp120 on the expression of the genes for the beta-chemokine MIP-1beta and its receptors CCR3 and CCR5 by ..
  45. ncbi Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy
    Wen Ying Chou
    Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Taipei, Taiwan
    Anesthesiology 105:334-7. 2006
    Animal and human studies indicate that genetics may contribute to the variability of morphine efficacy...
  46. ncbi The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance
    Jean Paul Laulin
    Universite Bordeaux 1, France
    Anesth Analg 94:1263-9, table of contents. 2002
    Perioperative opioids increase postoperative pain and morphine requirement, suggesting acute opioid tolerance. Furthermore, opioids elicit N-methyl-D-aspartate (NMDA)-dependent pain hypersensitivity...
  47. ncbi A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model
    Camilla Staahl
    Center for Visceral Biomechanics and Pain, Department of Gastroenterology, University Hospital Aalborg, Denmark
    Pain 123:28-36. 2006
    ..In animal experiments, oxycodone has shown different effects compared to morphine, and clinical observations have shown that oxycodone may occasionally be superior to, e.g...
  48. ncbi Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal
    Dan Georgescu
    Department of Psychiatry, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 23:3106-11. 2003
    ..nearby LH neurons expressing melanin-concentrating hormone (MCH), have mu-opioid receptors and respond to chronic morphine administration and opiate antagonist-precipitated morphine withdrawal...
  49. ncbi Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
    L M Bohn
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 408:720-3. 2000
    b>Morphine is a powerful pain reliever, but also a potent inducer of tolerance and dependence...
  50. ncbi Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients
    Dennis R Kerr
    Joint Orthopaedic Centre, New South Wales, Australia
    Acta Orthop 79:174-83. 2008
    ..The technique allows virtually immediate mobilization and earlier discharge from hospital...
  51. ncbi The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosci 22:9980-9. 2002
    Hypersensitivity resulting from nerve injury or morphine tolerance/hyperalgesia is predicted to involve similar cellular and molecular mechanisms...
  52. pmc Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway
    Thiago M Cunha
    Department of Pharmacology, Faculty of Medicine, Ribeirão Preto University of São Paulo, Ribeirao Preto, 14049 900 Sao Paulo, Brazil
    Proc Natl Acad Sci U S A 107:4442-7. 2010
    b>Morphine is one of the most prescribed and effective drugs used for the treatment of acute and chronic pain conditions. In addition to its central effects, morphine can also produce peripheral analgesia...
  53. ncbi A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia
    Alex T Sia
    Department of Women s Anaesthesia, KK Women s and Children s Hospital, 100 Bukit Timah Road, Singapore
    Anesthesiology 109:520-6. 2008
    ..variability at position 118 of the human mu-opioid receptor gene altered patients' response to intravenous morphine. The purpose of this study was to investigate whether this polymorphism contributes to the variability in ..
  54. ncbi Environmental and genetic factors associated with morphine response in the postoperative period
    Laurent Coulbault
    Pharmacology Department, Saint Antoine University of Medicine, University Pierre et Marie Curie, Paris, France
    Clin Pharmacol Ther 79:316-24. 2006
    The aim of this study was to investigate the respective influence of genetic and nongenetic factors on morphine dose requirements and adverse effects after colorectal surgery.
  55. ncbi Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines
    Vasudeva Raghavendra
    Department of Anesthesiology, HB 7125, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Pain 104:655-64. 2003
    ..hyperalgesia and allodynia that are refractory to standard treatment and often insensitive to opioids, such as morphine. Recent studies demonstrate spinal glial activation and increased proinflammatory cytokines in animal models of ..
  56. pmc COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia
    M Farooqui
    1Division of Hematology, Oncology and Transplantation, the Vascular Biology Center, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Br J Cancer 97:1523-31. 2007
    b>Morphine and its congener opioids are the main therapy for severe pain in cancer. However, chronic morphine treatment stimulates angiogenesis and tumour growth in mice...
  57. pmc Morphine enhances microglial migration through modulation of P2X4 receptor signaling
    Ryan J Horvath
    Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Neurosci 29:998-1005. 2009
    ..Using an in vitro culture system, we report that morphine increased microglial migration via a novel interaction between mu-opioid and P2X(4) receptors, which is dependent ..
  58. ncbi Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway
    Yong Chen
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 28:5836-45. 2008
    ..investigated the role of TRPV1, which is crucial for the transduction of noxious chemical and thermal stimuli, in morphine tolerance and tolerance-associated thermal hyperalgesia...
  59. ncbi A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine
    Ian N Johnston
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 24:7353-65. 2004
    ..of analgesic tolerance, thermal hyperalgesia, and tactile allodynia in response to chronic intrathecal morphine. Chronic (5 d), but not acute (1 d), intrathecal morphine was associated with a rapid increase in proinflammatory ..
  60. pmc Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation
    Jadwiga Turchan-Cholewo
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA
    J Neurochem 108:202-15. 2009
    ..is associated with altered microglial reactivity, the combined effects of human immunodeficiency virus-Tat and morphine were determined in cultured microglia...
  61. ncbi A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy
    Harald Lenz
    University of Oslo, Faculty Division Ullevaal University Hospital, Oslo, Norway
    Anesth Analg 109:1279-83. 2009
    In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain.
  62. ncbi Etanercept restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in morphine-tolerant rats
    Ching Hui Shen
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
    Anesth Analg 112:454-9. 2011
    In the present study we examined the effect of the tumor necrosis factor (TNF)-α antagonist etanercept on the antinociceptive effect of morphine in morphine-tolerant rats.
  63. ncbi Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief
    D Campa
    Department of Biology, University of Pisa, Pisa, Italy
    Clin Pharmacol Ther 83:559-66. 2008
    The pharmacokinetics and pharmacodynamics of morphine are under the control of several polymorphic genes, which can account for part of the observed interindividual variation in pain relief...
  64. pmc Potentiating effect of morphine on oral Salmonella enterica serovar Typhimurium infection is μ-opioid receptor-dependent
    Jessica M Breslow
    Center for Substance Abuse Research, Department of Microbiology, Temple University School of Medicine, 3400 N Broad St, Philadelphia, PA 19140, USA
    Microb Pathog 49:330-5. 2010
    Previous studies from our laboratory demonstrated that mice treated with morphine pellets are sensitized to Salmonella enterica, serovar Typhimurium infection...
  65. ncbi Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests
    G I Elmer
    Behavioral Pharmacology and Genetics Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Pain 75:129-40. 1998
    ..study was to determine the influence of genetic factors in nociception and its contribution to the potency of morphine to produce antinociception...
  66. ncbi In vitro antioxidant properties of morphine
    Ilhami Gulcin
    Department of Chemistry, Science and Arts Faculty, Ataturk University, 25240 Erzurum, Turkey
    Pharmacol Res 49:59-66. 2004
    b>Morphine is implicated in diverse functions, from development to immune modulation in the central and peripheral nervous systems. It has also been used extensively in the clinical management of pain due to its potent analgesic effect...
  67. ncbi Baclofen enhances extinction of opiate conditioned place preference
    S C Heinrichs
    Research Service VA Boston Healthcare System, Boston, MA, USA
    Behav Brain Res 207:353-9. 2010
    ..C57BL/6 mice were utilized in an unbiased conditioned place preference (CPP) protocol using morphine (10mg/kg, s.c.) and saline. CPP was measured by increases in time spent in the morphine-associated (CS+) vs...
  68. ncbi Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    J Pharmacol Exp Ther 334:1059-65. 2010
    ..Isobolographic analysis indicated antinociceptive synergism between milnacipran and morphine. Microdialysis studies revealed that milnacipran increased both 5-HT and NA levels in the spinal dorsal horn...
  69. ncbi Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study
    Wolnei Caumo
    Anesthesia Service and Perioperative Medicine, Hospital de Clinicas de Porto Alegre Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Pain 10:100-8. 2009
    ..Also, the anxiolytic effect of melatonin and clonidine resulted in reduced postoperative morphine consumption by more than 30%. However, in the mildly anxious, it was not observed the treatment effect on pain.
  70. ncbi Ultra-low dose naloxone upregulates interleukin-10 expression and suppresses neuroinflammation in morphine-tolerant rat spinal cords
    Shinn Long Lin
    Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan
    Behav Brain Res 207:30-6. 2010
    Co-infusion of ultra-low dose naloxone and morphine attenuates morphine tolerance through the prevention of mu opioid receptor-Gs protein coupling...
  71. pmc Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9
    Temugin Berta
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Pain 8:18. 2012
    ..We examined acute morphine-induced activation of satellite glial cells (SGCs) and up-regulation of IL-1β in dorsal root ganglia (DRGs), and ..
  72. pmc Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids
    Xian Yu Liu
    Center for the Study of Itch, Washington University School of Medicine Pain Center, St Louis, MO 63110, USA
    Cell 147:447-58. 2011
    ..We now report that the μ-opioid receptor (MOR) isoform MOR1D is essential for morphine-induced scratching (MIS), whereas the isoform MOR1 is required only for morphine-induced analgesia (MIA)...
  73. ncbi Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance
    Xu Zhang
    Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Trends Pharmacol Sci 27:324-9. 2006
    ..Experiments in animals show that MOP-receptor-mediated spinal analgesia is enhanced and morphine tolerance does not develop when DOP receptor functions are pharmacologically or genetically attenuated...
  74. ncbi ¹H NMR-based metabonomic analysis of brain in rats of morphine dependence and withdrawal intervention
    Zhengtao Hu
    National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Behav Brain Res 231:11-9. 2012
    Metabolic consequences of morphine dependence and withdrawal intervention have not been well explored...
  75. pmc Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression
    Jaclyn M Schwarz
    Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27705, USA
    J Neurosci 31:17835-47. 2011
    ..and astrocytes can profoundly affect the physiological and addictive properties of drugs of abuse, including morphine. We report that glia within the rat nucleus accumbens (NAcc) respond to morphine with an increase in cytokine/..
  76. ncbi Intrathecal combination of ziconotide and morphine for refractory cancer pain: a rapidly acting and effective choice
    Ilaria Alicino
    Anesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    Pain 153:245-9. 2012
    ..The aim of this work is to assess the safety and efficacy of intrathecal (IT) combination of ziconotide and morphine in malignant pain refractory to high doses of oral opioids...
  77. pmc Preservation of retina ganglion cell function by morphine in a chronic ocular-hypertensive rat model
    Shahid Husain
    Hewitt Laboratory of the Ola B Williams Glaucoma Center, Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Invest Ophthalmol Vis Sci 53:4289-98. 2012
    The current study examined if opioid-receptor-activation by morphine can improve retinal function and retinal ganglion cell (RGC) integrity in a chronic glaucoma rat model.
  78. pmc HIV-1 coinfection and morphine coexposure severely dysregulate hepatitis C virus-induced hepatic proinflammatory cytokine release and free radical production: increased pathogenesis coincides with uncoordinated host defenses
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 1217 East Marshall Street, Richmond, VA 23298 0613, USA
    J Virol 85:11601-14. 2011
    ..b>Morphine (the bioactive product of heroin), HIV-1 Tat and the MN strain gp120 (gp120(MN)) proteins, and X4 HIV-1(LAI/IIIB) ..
  79. pmc Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens
    Haosheng Sun
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 32:17454-64. 2012
    ..Here, we show that chronic morphine, like cocaine, decreases G9a expression, and global levels of H3K9me2, in mouse nucleus accumbens (NAc), a key ..
  80. pmc The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine
    Daniel T Baptista-Hon
    The Institute of Academic Anaesthesia, Centre for Neuroscience, University of Dundee, Dundee, UK
    Br J Pharmacol 165:693-704. 2012
    b>Morphine is an antagonist at 5-HT(3) A receptors. 5-HT(3) and opioid receptors are expressed in many of the same neuronal pathways where they modulate gut motility, pain and reinforcement...
  81. ncbi Bupivacaine, ropivacaine, and morphine: comparison of toxicity on human hamstring-derived stem/progenitor cells
    Florian Haasters
    Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig Maximilians University Munich, Nussbaumstr 20, 80336, Munich, Germany
    Knee Surg Sports Traumatol Arthrosc 19:2138-44. 2011
    Bupivacaine, ropivacaine, and morphine are commonly administered intraarticularly after anterior cruciate ligament (ACL) reconstruction. However, their effects on human tendon stem/progenitor cells (TSPC) have not been studied...
  82. ncbi Protective role of taurine against morphine-induced neurotoxicity in C6 cells via inhibition of oxidative stress
    Jiaqing Zhou
    National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Gaopeng Street, High Technological Development Zone, Chengdu 610041, China
    Neurotox Res 20:334-42. 2011
    This study was carried out to investigate the protective role of taurine (2-aminoethanesulphonicacid) against morphine-induced neurotoxicity in C6 cells...
  83. ncbi Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats
    Esmaeal Tamaddonfard
    Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia 57153 1177, Iran
    Pharmacol Rep 63:423-32. 2011
    ..pyrilamine (an antagonist of histamine H(1) receptors), ranitidine (an antagonist of histamine H(2) receptors), morphine (an opioid receptor agonist) and naloxone (an opioid receptor antagonist) in separate and combined treatments...
  84. ncbi Neonatal morphine administration leads to changes in hippocampal BDNF levels and antioxidant enzyme activity in the adult life of rats
    J R Rozisky
    Pain Pharmacology and Neuromodulation Laboratory Animal Models, Department of Pharmacology, Institute of Basic Health Sciences ICBS, Federal University of Rio Grande do Sul UFRGS, Rua Sarmento Leite, 500 Sala 202, Porto Alegre, RS, 90050 170, Brazil
    Neurochem Res 38:494-503. 2013
    ..stress markers associated with cell viability, and TNF-α in the short, medium and long term after repeated morphine treatment in early life...
  85. ncbi A human gene encoding morphine modulating peptides related to NPFF and FMRFamide
    S J Perry
    Sussex Centre for Neuroscience, University of Sussex, Brighton, UK
    FEBS Lett 409:426-30. 1997
    ..On rat spinal cord, the larger peptide is indistinguishable in activity from the equivalent bovine peptide whereas the smaller extended peptide is inactive...
  86. ncbi Influence of low doses of naltrexone on morphine antinociception and morphine tolerance in male and female rats of four strains
    Jolan M Terner
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Pain 122:90-101. 2006
    ..actions of opioids contribute to sex as well as strain differences in opioid sensitivity, the effects of morphine alone and in combination with low doses of naltrexone were examined in male and female rats of four strains...
  87. ncbi Comparison of the antinociceptive effect of acute morphine in female and male Sprague-Dawley rats using the long-lasting mu-antagonist methocinnamox
    Elizabeth M Peckham
    Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, Ann Arbor, MI 48109, USA
    Brain Res 1058:137-47. 2005
    Male rats are more sensitive than female rats to the antinociceptive action of morphine. The present study used age-matched (9-10 weeks old) male and female Sprague-Dawley rats to investigate whether this difference is due to variation in ..
  88. pmc Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction
    Jaclyn M Schwarz
    Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27705, USA
    J Neurosci 33:961-71. 2013
    ..To test this, rats were treated with a subchronic regimen of morphine or saline in adolescence, and their preference for morphine was examined using conditioned place preference (CPP) ..
  89. ncbi Effects of morphine and alcohol on functional brain connectivity during "resting state": a placebo-controlled crossover study in healthy young men
    Najmeh Khalili-Mahani
    Leiden Institute for Brain and Cognition, Leiden University, The Netherlands
    Hum Brain Mapp 33:1003-18. 2012
    ..seven resting-state fMRI scans were obtained in 12 healthy young men in three different drug sessions (placebo, morphine and alcohol; randomized)...
  90. pmc CXCR4 signaling mediates morphine-induced tactile hyperalgesia
    Natalie M Wilson
    Department of Molecular Pharmacology and Therapeutics, Loyola University of Chicago, Maywood, IL 60153, USA
    Brain Behav Immun 25:565-73. 2011
    b>Morphine and related compounds are the first line of therapy in the treatment of moderate to severe pain...
  91. ncbi The involvement of glial cells in the development of morphine tolerance
    P Song
    Shanghai Institute of Physiology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, PR China
    Neurosci Res 39:281-6. 2001
    Glial response to chronic morphine treatment was examined by immunohistochemistry of glial fibrillary acidic protein (GFAP), a specific marker for astroglial cells. Systemic administration of morphine (50 mg/kg, i.p...
  92. ncbi Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation?
    Jorn Lotsch
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Pain 144:119-24. 2009
    Activation of codeine by O-demethylation into morphine is a prerequisite for its analgesic effects and severe toxicity...
  93. ncbi Forced exercise improves passive avoidance memory in morphine-exposed rats
    K Saadipour
    Physiology Research Center, Department of Physiology, Medicine Faculty, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran
    Pak J Biol Sci 12:1206-11. 2009
    ..this study was to investigate the effect of short-term forced exercise protocol on passive avoidance retention in morphine-exposed rats...
  94. pmc Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1178-89. 2008
    ..Recently, one proinflammatory cytokine, interleukin-1, was also implicated in the loss of analgesia upon repeated morphine exposure (tolerance)...
  95. pmc Systemic morphine produce antinociception mediated by spinal 5-HT7, but not 5-HT1A and 5-HT2 receptors in the spinal cord
    A Dogrul
    Department of Pharmacology, Gülhane Academy of Medicine, Ankara, Turkey
    Br J Pharmacol 149:498-505. 2006
    ..system within the spinal cord have been proposed to play an important role in the analgesic effects of systemic morphine. Currently, seven groups of 5-HT receptors (5-HT1-7) have been characterized...
  96. ncbi Diabetes abolishes morphine-induced cardioprotection via multiple pathways upstream of glycogen synthase kinase-3beta
    Eric R Gross
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Diabetes 56:127-36. 2007
    ..Groups of NDBR or DBR were administered either vehicle, morphine (0.3 mg/kg), or the GSK inhibitor SB216763 (0.6 mg/kg) 5 min before reperfusion...
  97. ncbi Activation of stress-related hypothalamic neuropeptide gene expression during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University of Murcia, Murcia, Spain
    J Neurochem 101:1060-71. 2007
    b>Morphine withdrawal results in serious affective and somatic symptoms including activation of the hypothalamo-pituitary-adrenocortical (HPA) axis...
  98. pmc Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward
    Glenda C Harris
    Department of Psychiatry, University of Pennsylvania, Translational Research Labs 3403, 125 S 31st Street, Philadelphia, PA 19104, United States
    Behav Brain Res 183:43-51. 2007
    ..Here, we examine for the first time the role of these neurons in the acquisition of morphine CPP...
  99. ncbi Reward value of intromissions and morphine in male rats evaluated by conditioned place preference
    Francisco J Camacho
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico
    Physiol Behav 98:602-7. 2009
    ..We also compared the rewarding properties of one ejaculation and a morphine injection...
  100. ncbi Acupuncture suppresses morphine self-administration through the GABA receptors
    Seong Shoon Yoon
    Department of Physiology, College of Oriental Medicine, Daegu Haany University, Suseong gu, Daegu 706 828, South Korea
    Brain Res Bull 81:625-30. 2010
    The neurobiological substrate for morphine self-administration in animals is believed to involve the dopamine system of the nucleus accumbens...
  101. pmc Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine
    M M J Veeneman
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Psychopharmacology (Berl) 214:863-76. 2011
    ..Stimulation of dopamine receptors plays an important role in drug reward, but not in the sensitizing properties of cocaine and morphine.

Research Grants76

  1. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    Continuous intrathecal morphine infusion is used in the control of chronic pain...
  2. Therapeutic Approaches for Extinction of Conditioned Drug Reward
    Gary B Kaplan; Fiscal Year: 2013
    ..We hypothesize that repeated conditioning with morphine produces COR that is mediated by plasticity in motivational and cognitive neural circuits...
  3. Genomic adaptation to HIV infection of the CNS in opioid-abusers
    Rajnish S Dave; Fiscal Year: 2012
    ..study corroborates the notion of genomic adaptation, as alterations in miRNA expression were correlated with morphine treatment...
  4. Pain and Hypoxia in Premature Neonates
    DANILYN MAG AKAT ANGELES; Fiscal Year: 2012
    ..However, recent multicenter clinical studies aimed at improving neurologic outcome by decreasing pain with morphine were inconclusive [Bellu et al, 2008;[Anand et al, 2004; Simons et al, 2003]...
  5. Preclinical studies of a heroin/morphine vaccine for opiate addiction
    Paul R Pentel; Fiscal Year: 2013
    ..A heroin/morphine addiction treatment vaccine candidate has been developed which appears in preliminary studies to be highly ..
  6. EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUS
    Richard C Deth; Fiscal Year: 2012
    ..We will measure the dose and time-dependent effects of morphine, amphetamine and alcohol on the cellular uptake of [35S]-cysteine, which primarily reflects EAAT3 activity...
  7. Vaccines for Sustainable Therapy of Opiate Addiction
    Frank M Orson; Fiscal Year: 2012
    ..Any effective vaccine for heroin will have to elicit high levels of antibodies that bind heroin, morphine, and other active metabolites, since concentrations of pharmacologically active opiates exceed the usual amounts ..
  8. Immediate and Delayed Effects of Morphine on Brain Circuits: Animal and Human Cor
    Dusica Bajic; Fiscal Year: 2013
    ..We hypothesize that prolonged morphine exposure in the neonatal period will lead to a significant decrease in volume and connectivity of the amygdala ..
  9. Opioidergic System: Its Role(s) in Glaucoma
    Shahid Husain; Fiscal Year: 2013
    ..Preliminary data presented in this application provide concrete evidence that: 1) administration of morphine in a chronic ocular-hypertensive rat model protected functional and structural integrity of RGCs;2) activation of ..
  10. 18F-beta-Endorphin Imaging: Translational Study of an Opioid Peptide Radiotracer
    BRIAN contact REED; Fiscal Year: 2010
    ..MOP-r), the target of addictive opioids such as heroin and prescription opioid analgesics such as oxycodone and morphine. MOP-r are also prominently involved in the downstream effects of cocaine and alcohol addiction, and also ..
  11. Anabolic-androgenic steroids enhance motivation
    Ruth I Wood; Fiscal Year: 2013
    ..Aim 1 will determine if AAS increase motivation for aggression (Aim 1A), mating (Aim 1B) and morphine self- administration (Aim 1C). Aim 2 will explore neural mechanisms for these effects...
  12. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012
    ..Notable examples include the use of natural analgesics, such as morphine (from the opium poppy) and salicylate (from willow bark) to discover opioid receptors and cyclooxgenases, ..
  13. P450 Epoxygenase Mechanisms of Opioid Analgesia
    LINDSAY HOUGH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Morphine acts on mu opioid receptors in the brain and spinal cord to produce dramatic pain relief, but mu-associated side effects (including tolerance and substance abuse) limit its use...
  14. PTHrP Modulation of TRPV1 in Pain Associated with Breast Cancer Bone Metastasis
    AARON DAVID MICKLE; Fiscal Year: 2013
    ..to chronic pain in the limbs, pelvis and spines, which is undermanaged with existing pain medications, mainly morphine derivatives...
  15. Mechanisms of regulation of ethanol intake by lateral habenula
    Jiang Hong Ye; Fiscal Year: 2013
    ..work has shown that the habenula plays a key role in nicotine addiction and withdrawal and in the regulation of morphine self-administration, as well as cocaine seeking behavior...
  16. Effect of Articular Neurotoxin on Joint Pain and Neurochemical Signature
    Maren Lawson Mahowald; Fiscal Year: 2012
    ..such as intra-articular capsaicin, resiniferatoxin and iodo-resiniferatoxin to standard pain medications such as morphine using these measures of tenderness, pain behavior, activity and gait...
  17. Extinction is mediated by the infralimbic cortex and protein kinase C epsilon
    Philip M Newton; Fiscal Year: 2010
    ..medial prefrontal cortex of mice and then examine the extinction of a conditioned place preference for cocaine, morphine and ethanol...
  18. Drugs of Abuse Affecting AIDS Pathogenesis
    Thomas J Rogers; Fiscal Year: 2012
    ..Project 1 will address the combined influence of morphine and SIV infection on the expression of critical chemokines and chemokine receptors that play an important role in ..
  19. Opioid tolerance and bowel dysfunction
    William L Dewey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Morphine remains one of the most frequently prescribed drugs for the treatment of moderate to severe pain, including pain due to cancer or surgery...
  20. A Molecular Analysis of the Gateway Hypothesis in Mice
    Amir Levine; Fiscal Year: 2012
    ..to nicotine), and whether nicotine can also enhance the response to drugs of abuse other that cocaine, such as morphine. (2) To determine the molecular mechanisms by which nicotine primes an animal to the effects of cocaine, we ..
  21. Vaccines for the Treatment of Opiate Addiction
    Kim D Janda; Fiscal Year: 2013
    ..In particular the development of heroin/morphine protein conjugates, termed heroin/morphine conjugate vaccines (HCVs), will be advanced in the hopes to reduce ..
  22. Beta-lactam chemical probes for GLT-1 transporter-related pathologies
    Scott M Rawls; Fiscal Year: 2010
    ..b-lactam containing compounds displaying enhanced brain penetrability and GLT-1 activity will block morphine tolerance and physical dependence and heroin and cocaine self-administration in rats through GLT-1 transporter ..
  23. Role of peroxynitrite in morphine hyperalgesia and tolerance
    Daniela Salvemini; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Opiates like morphine sulfate are the most effective analgesics for treating acute and chronic severe pain, but their use is limited by development of tolerance and hypersensitivity to innocuous and ..
  24. Mechanisms and Consequences of Locus Coeruleus Activation
    KENICHIRO HAYASHIDA; Fiscal Year: 2013
    ..many approved treatments for neuropathic pain recruit, augment, or mimic bulbospinal inhibition including morphine, noradrenaline (NA) re-uptake inhibitors, and clonidine...
  25. Molecular Regulation of GABA(A) Receptor Function in Amygdala
    Kerry J Ressler; Fiscal Year: 2010
    ..In fact, recent studies have suggested that morphine, alcohol, cocaine and nicotine may also alter GABAA functioning in amygdala, and acutely enhancing GABA levels ..
  26. PATERNAL OPIOID EXPOSURE IMPARTS BIOBEHAVIORAL DEFICITS IN THEIR OFFSPRING
    Theodore J Cicero; Fiscal Year: 2013
    ..b>Morphine was one of the first drugs shown to have paternal-mediated consequences for offspring...
  27. Functional Interactions between Cancer Cells and Sensory Neurons
    DONALD SIMONE; Fiscal Year: 2012
    ..Moreover, opioids modulate signaling at P2X receptors. Opioids such as morphine decrease ATP-evoked currents that occur through P2X receptors...
  28. Drug Discovery for Cognitive Impairment Associated with Drugs of Abuse
    Alvin V Terry; Fiscal Year: 2013
    ..Ten of these will progress to studies in rat models of chronic morphine, cocaine, and nicotine self-administration...
  29. Novel tools for identifying GPCR compounds modulating specific sub-cellular ERK a
    Haifeng Eishingdrelo; Fiscal Year: 2013
    ..We plan to validate the assay by using the m-opioid receptor (MOR) and its ligand morphine for nuclear location of the ERK2 activation pathway, since morphine is known to activate G-protein-dependent ERK ..
  30. Galanin-opiate interactions
    Marina R Picciotto; Fiscal Year: 2012
    ..is a protective factor against behavioral and neurochemical correlates of opiate addiction in mice, including morphine-induced locomotor activation, conditioned place preference and withdrawal...
  31. The role of CCR5 in HIV-1 Tat and morphine-mediated neurodegeneration.
    Elizabeth M Podhaizer; Fiscal Year: 2013
    ..Our laboratory is interested in identifying convergent mechanisms between HIV-1 proteins and morphine, the active metabolite of heroin in the CNS, that contribute to the pathology of HIV-1 infection...
  32. Modulation of Pruritus by Spinal Cannabinoids
    Gregory W Terman; Fiscal Year: 2010
    ..that, like nociception, itch sensation, also appears to be increased in animals previously exposed to repeated morphine injections - although this effect is largely masked by concurrent spinal endocannabinoid inhibition...
  33. Opioid selection and the risk of serious infections in older adults
    Carlos G Grijalva; Fiscal Year: 2013
    ..Studies in animal models suggest that, taking the chemical structure of morphine as reference, opioids with hydroxyl groups at both C3 and C6 (e.g...
  34. Monoacylglycerol Lipase Inhibitors for Treating Opioid Use Disorders
    Aron H Lichtman; Fiscal Year: 2013
    ..in brain 2-AG levels and robustly reduces the magnitude of naloxone-precipitated somatic withdrawal responses in morphine-dependent mice, but elicits far fewer cannabimimetic effects compared with THC...
  35. Regulation of opioid receptor function in trigeminal ganglion
    William P Clarke; Fiscal Year: 2012
    Description (provided by applicant): Agonists acting at the 5 opioid receptor (MOR) (e.g. morphine and its analogs) are the mainstay of pain management;however there are serious adverse effects (e.g...
  36. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2012
    ..Lastly, we will determine whether administration of reference analgesics (morphine, gabapentin) or novel analgesics that regulate peptidergic (a CGRP antagonist, anti-NGF antibody) or non-..
  37. Mu-Opioid Effects on the Central Mechanisms that Control Breathing
    Edward J Zuperku; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Morphine and synthetic 5-opioid receptor (5OR) analogs such as fentanyl and remifentanil (remi) are highly effective analgesics used to treat severe acute and chronic pain...
  38. Studies on the the mechanism of OPRM1 biased agonism and in vivo consequences: Di
    Ping Yee Law; Fiscal Year: 2013
    ..During the course of our studies on ?-opioid receptor (OPRM1) biased agonism, we observed that morphine and fentanyl, two highly prescribed opioids, regulate the microRNA-190 level differentially, leading to ..
  39. The Role of Mu-opioid Receptor Splice Variants in the HIV Disease
    SETH MICHAEL DEVER; Fiscal Year: 2013
    ..Furthermore, we found that the MOR variants we examined differed in morphine-mediated calcium signaling...
  40. Local health impacts of Prescription Monitoring Program use
    Traci C Green; Fiscal Year: 2013
    ..nonmedical use, predefined typologies of prescription opioid use, street price), supply (prescribing patterns, morphine-equivalent dose dispensed, source of prescription opioid), and harm among nonmedical prescription opioid users (..
  41. Ethanol-induced conditioned partner preference in mice
    Ruth I Wood; Fiscal Year: 2013
    ..2 will expand the conditioned partner preference model to test the effects of other drugs of abuse (amphetamines, morphine) on social bonding...
  42. Clavulanic acid: a potential abuse-deterrent and CNS-active therapeutic
    Scott M Rawls; Fiscal Year: 2012
    ..Both b-lactam compounds display anti-glutamate activity in both in vitro and in vivo assays. They also disrupt morphine analgesic tolerance and cocaine self-administration in rodents and display anti-seizure-like activity in ..
  43. The Opioid mesolimbic system in heroin abuse
    Yasmin L Hurd; Fiscal Year: 2013
    ..to understanding the regulation of 5-opioid receptor (MOR), molecular target of heroin metabolites such as morphine, but limited studies have been conducted directly in the human brain regarding MOR and its intracellular ..
  44. Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) Trial
    ERIN ELIZABETH KREBS; Fiscal Year: 2013
    ..are to compare two prescribing strategies: 1) an opioid-intensive strategy that uses strong opioids, such as morphine, early in treatment, and 2) an opioid-avoidant strategy that optimizes non-opioid medications while delaying and ..
  45. Regulation of Tyrosine Hydroxylase by CLOCK: Potential Mechanisms Underlying the
    WILBUR PUTNEY WILLIAMS; Fiscal Year: 2013
    ..dopaminergic tone in the NAcc and precipitates the heightened sensitivity to rewarding stimuli, including ICSS, morphine and cocaine observed in these animals...
  46. A Comparison of Buprenorphine Versus Morphine in the Treatment of the Neonatal Ab
    Walter K Kraft; Fiscal Year: 2013
    ..Administration of oral morphine is associated with lengths of treatment of 8-79 days in the hospital setting...
  47. Effects of morphine on the morphology of the hypocretin and MCH systems
    Jerome M Siegel; Fiscal Year: 2013
    ..studies for this proposal, we then found that Hcrt cells in mice sacrificed after a 3 day period of continuous morphine administration were of normal number, but had reduced neuronal volume and altered morphology...
  48. Genome-wide protein-DNA interactions responding to chronic opioid treatment
    Yulong Chen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chronic morphine exposure leads to stable changes in gene expression in the brain reward, pain, and learning and memory circuits, resulting in neuroadaptations that underlie drug tolerance, physical ..
  49. HIV drug abusers, polymorphisms and brain plasticity
    Italo Mocchetti; Fiscal Year: 2012
    ..It is believed that heroin, morphine and other intravenous opiate drugs may exacerbate the neurotoxic effect of HIV...
  50. Crystallization and structure determination of the mu-opioid receptor
    Roger K Sunahara; Fiscal Year: 2012
    ..The [unreadable] opioid receptor ([unreadable]OR) is the main mediator of the analgesic effect of morphine and other opioid receptor (OR) agonists...
  51. Engineered Opioid Receptors as Therapeutic Agents for Pain Control
    Ping Yee Law; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: In the treatment of moderate to severe pain, morphine remains the drug of choice...
  52. Mentoring and Research in Placebo Studies, Asian Medicine, and CAM
    Ted Kaptchuk; Fiscal Year: 2013
    ..A PET-fMRI study will investigate placebo responses dependent on morphine conditioning verses ketorolac conditioning...
  53. Regulation of Itch Scratching by Spinal GRP Receptors in Primates
    Mei Chuan Ko; Fiscal Year: 2013
    ..In particular, previous studies have demonstrated that intrathecally administered morphine-induced scratching behavior in monkeys is mediated by central mu opioid receptors...
  54. Pseudomonas'effects on the gut barrier from surgery
    John C Alverdy; Fiscal Year: 2012
    ..immune elements (interferon 3), 2.) opioids (morphine, dynorphin), and 3.) end-products of cellular hypoxia (adenosine)...
  55. Metabolism of Carcinogens and Drugs by Human P450s
    F Peter Guengerich; Fiscal Year: 2013
    ..A related aspect is establishment of the roles of individual human P450s in morphine biosynthesis, forwhich strong evidence has been recently presented by others...
  56. Therapeutic Small Molecule Modulators of G beta gama Signaling
    Val S Goodfellow; Fiscal Year: 2011
    ..They have demonstrated that these compounds are efficacious in animal models of heart failure, inflammation, and morphine-dependent analgesia. Califia Bio, Inc...
  57. Analgesics targeting truncated 6transmembrane exon 11 variants of MOR-1 (6TM-E11)
    Susruta Majumdar; Fiscal Year: 2013
    ..IBNtxA is an effective analgesic, with a potency 10-fold greater than morphine. This analgesia persists in the triple KO mice, but is lost in the exon 11 KO mice...
  58. N-type Calcium Channels in Nociceptive Neurons
    Diane Lipscombe; Fiscal Year: 2013
    ..2-e37a, is significantly more sensitive to drugs that act through G protein coupled receptors, including morphine. This is important because i) we previously showed that CaV2...
  59. Rhodopsin endocytic trafficking and Drosophila visual sensitivity
    Hong Sheng Li; Fiscal Year: 2010
    ..Failure of this process has been implicated in drug tolerances such as that to morphine. Although a large body of works has elicited various mechanisms of receptor endocytosis in cultured cells, the ..
  60. Glial origins of HIV and opiate-driven synaptodendritic injury
    Pamela E Knapp; Fiscal Year: 2013
    ..We recently reported that convergent, neurotoxic effects of Tat or gp120 and morphine are largely due to actions of MOR+ glia...
  61. Opioid Abuse, opportunistic infection and NeuroAIDS
    Sabita Roy; Fiscal Year: 2013
    ..In preliminary studies we demonstrate that chronic morphine treatment in the presence of TAT synergistically increases susceptibility to S...
  62. Interactions Between the Brain Reward and Pain Systems.
    Conan Kornetsky; Fiscal Year: 2010
    ..research is to study the interaction of the brain reward system with the brain pain system and the effects of morphine on this interaction...
  63. Evaluation of the Washington State Guidelines on Opioid Dosing for Chronic Pain
    Gary M Franklin; Fiscal Year: 2011
    ..focused primarily on dosing guidance for chronic non-cancer pain at or above a "yellow flag" dose of 120 mg/day morphine equivalent (MED)...
  64. OPIOID EFFECTS ON HYPOTHALAMIC NEURONAL EXCITABILITY
    Martin Kelly; Fiscal Year: 2002
    ..In Experiments 1, we will test the hypothesis that chronic morphine activates a protein kinase A (PKA) pathway to specifically uncouple mu-opioid receptors in arcuate neurons...
  65. Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department
    Polly Bijur; Fiscal Year: 2009
    ..In that setting, patients typically receive titration of morphine until the patient is comfortable and then PCA is initiated...
  66. HYPOTHALAMUS & NARCOTIC EFFECTS
    HEMENDRA BHARGAVA; Fiscal Year: 1992
    ..to develop neuropeptide analogs with oral activity, enzymatic stability and long duration of action in inhibiting morphine tolerance-dependence and abstinence processes...
  67. Morphine in Mammals
    MEINHART ZENK; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Morphine, one of the strongest analgesics known, is produced by and commercially isolated from the opium poppy plant...
  68. CENTER FOR THE STUDY OF EMOTION AND ATTENTION
    Peter Lang; Fiscal Year: 2009
    We have found in the fear potentiated startle test that bilateral local infusion of morphine into the medial nucleus of the amygdala (Me) completely blocks the expression of conditioned fear whereas infusion of comparable doses into the ..
  69. OPIATE MODULATION OF PULMONARY INFECTION
    Thomas Molitor; Fiscal Year: 2000
    ..Because of morphine's effects on cell-mediated immunity, opiate abuse has been suspected of increasing the susceptibility to TB...
  70. Role of AMPA receptors in the nucleus accumbens shell in morphine depedence
    Elena Chartoff; Fiscal Year: 2009
    ..to investigate how synaptic plasticity of AMPA glutamate receptors in the nucleus accumbens shell (NASh) mediates morphine dependence...
  71. Opioid-Induced Immune Alterations: Gender Differences
    DONALD LYSLE; Fiscal Year: 2006
    ..Specific Aim I provides a pharmacological analysis of the effects of morphine on the contact hypersensitivity (CHS) response in males and females, with an emphasis on clinical outcome ..
  72. OPIATE RECEPTORS EEG SPECTRA TOLERANCE & DEPENDENCE
    Gerald Young; Fiscal Year: 1992
    Dynorphin fragments, mu/delta ligands, delta ligands and certain nonopioid peptides regulate in vivo morphine-induced and beta-endorphin-induced effects...
  73. TOLERANCE TO MORPHINE ANALGESIA--BIOBEHAVIOR FACTORS
    ANTHONY VACCARINO; Fiscal Year: 1999
    ..We propose to characterize the mechanisms that underlie the development of tolerance to morphine analgesia by testing the hypothesis that "stress-triggered" changes during pain influence the therapeutic actions ..
  74. PERMEABILITY OF MORPHINE ACROSS BBB DURING DEVELOPMENT
    Anil Gulati; Fiscal Year: 1993
    ..b>Morphine is being increasingly advocated as an analgesic in newborns...
  75. Morphine versus Methadone as First Line Strong Opioid for Cancer Pain
    Eduardo Bruera; Fiscal Year: 2009
    ..The great majority of these patients will require opioid analgesics for appropriate pain control. Morphine is recommended as a first line opioid by the World Health Organization Cancer Pain Relief Guidelines...
  76. THALAMOSTRIATAL MECHANISMS OF MORPHINE ACTION
    Richard Harlan; Fiscal Year: 2003
    Drugs of abuse, such as heroin and morphine, have exacted an incalculable toll on society. Our understanding of the effects of opiates is still limited, in part due to an incomplete knowledge of the neural circuitries affected by morphine...