meperidine

Summary

Summary: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.

Top Publications

  1. ncbi Oral ketamine/midazolam is superior to intramuscular meperidine, promethazine, and chlorpromazine for pediatric cardiac catheterization
    S M Auden
    Departments of Anesthesiology, Pediatrics, and Family and Community Medicine of the University of Louisville and Kosair Children s Hospital, Louisville, KY 40202, USA
    Anesth Analg 90:299-305. 2000
  2. ncbi Meperidine versus valethamate bromide in shortening the duration of active labor
    Bulent Yilmaz
    Department of Obstetrics and Gynecology, Zekai Tahir Burak Women s Health, Education and Research Hospital, Ankara, Turkey
    Int J Gynaecol Obstet 107:126-9. 2009
  3. ncbi Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    J W Langston
    Science 219:979-80. 1983
  4. ncbi Side effects of opioids during short-term administration: effect of age, gender, and race
    M Soledad Cepeda
    Department of Anesthesiology, and Clinical Epidemiology Unit Javeriana Univeristy, Bogota, Colombia
    Clin Pharmacol Ther 74:102-12. 2003
  5. ncbi Nurse-administered propofol versus midazolam and meperidine for upper endoscopy in cirrhotic patients
    Brian R Weston
    Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 98:2440-7. 2003
  6. ncbi CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes
    Jacqueline Ramirez
    University of Chicago, Department of Medicine, Section of Hematology Oncology, 5841 S Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Drug Metab Dispos 32:930-6. 2004
  7. ncbi Propofol alone versus propofol in combination with meperidine for sedation during colonoscopy
    Yu Hsi Hsieh
    Division of Gastroenterology, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia Yi, Taiwan, ROC
    J Clin Gastroenterol 43:753-7. 2009
  8. ncbi Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKBR3 cells with: cis -platin, Tamoxifen, Melphalan, Betulinic acid, L-PDMP, L-PPMP, and GD3 ganglioside
    Subhash Basu
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Glycoconj J 20:563-77. 2004
  9. ncbi Obstetric analgesia: a comparison of patient-controlled meperidine, remifentanil, and fentanyl in labour
    M R Douma
    Department of Obstetrics and Gynaecology, HagaZiekenhuis location Red Cross, PO Box 60605, 2506 LP The Hague, The Netherlands
    Br J Anaesth 104:209-15. 2010
  10. ncbi Dexmedetomidine and meperidine additively reduce the shivering threshold in humans
    Anthony G Doufas
    Outcomes Research Institute and the Department of Anesthesiology, Louisville, KY, USA
    Stroke 34:1218-23. 2003

Detail Information

Publications235 found, 100 shown here

  1. ncbi Oral ketamine/midazolam is superior to intramuscular meperidine, promethazine, and chlorpromazine for pediatric cardiac catheterization
    S M Auden
    Departments of Anesthesiology, Pediatrics, and Family and Community Medicine of the University of Louisville and Kosair Children s Hospital, Louisville, KY 40202, USA
    Anesth Analg 90:299-305. 2000
    An IM combination of meperidine, promethazine, and chlorpromazine (DPT) has been given as sedation for pediatric procedures for more than 40 years...
  2. ncbi Meperidine versus valethamate bromide in shortening the duration of active labor
    Bulent Yilmaz
    Department of Obstetrics and Gynecology, Zekai Tahir Burak Women s Health, Education and Research Hospital, Ankara, Turkey
    Int J Gynaecol Obstet 107:126-9. 2009
    To compare the efficacy and safety of meperidine hydrochloride and valethamate bromide against placebo in shortening the duration of active labor.
  3. ncbi Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    J W Langston
    Science 219:979-80. 1983
    ..On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra...
  4. ncbi Side effects of opioids during short-term administration: effect of age, gender, and race
    M Soledad Cepeda
    Department of Anesthesiology, and Clinical Epidemiology Unit Javeriana Univeristy, Bogota, Colombia
    Clin Pharmacol Ther 74:102-12. 2003
    ..Our objective was to evaluate the effect of the type of opioid, age, gender, and race on the incidence of side effects from short-term opioid use...
  5. ncbi Nurse-administered propofol versus midazolam and meperidine for upper endoscopy in cirrhotic patients
    Brian R Weston
    Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 98:2440-7. 2003
    ..Propofol is currently under evaluation as an alternative to the combination of midazolam and meperidine for sedation during endoscopic procedures...
  6. ncbi CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes
    Jacqueline Ramirez
    University of Chicago, Department of Medicine, Section of Hematology Oncology, 5841 S Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Drug Metab Dispos 32:930-6. 2004
    b>Meperidine is an opioid analgesic metabolized in the liver by N-demethylation to normeperidine, a potent stimulant of the central nervous system...
  7. ncbi Propofol alone versus propofol in combination with meperidine for sedation during colonoscopy
    Yu Hsi Hsieh
    Division of Gastroenterology, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia Yi, Taiwan, ROC
    J Clin Gastroenterol 43:753-7. 2009
    ..Both propofol alone and propofol in combination with meperidine are frequently used during colonoscopy, but the impact of adding meperidine has not been evaluated...
  8. ncbi Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKBR3 cells with: cis -platin, Tamoxifen, Melphalan, Betulinic acid, L-PDMP, L-PPMP, and GD3 ganglioside
    Subhash Basu
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Glycoconj J 20:563-77. 2004
    ..However, apoptosis in carcinoma cells in the presence of cis -platin is induced by a caspase 3 activation pathway without any increase in synthesis of ceramide...
  9. ncbi Obstetric analgesia: a comparison of patient-controlled meperidine, remifentanil, and fentanyl in labour
    M R Douma
    Department of Obstetrics and Gynaecology, HagaZiekenhuis location Red Cross, PO Box 60605, 2506 LP The Hague, The Netherlands
    Br J Anaesth 104:209-15. 2010
    To compare the analgesic efficacy of remifentanil with meperidine and fentanyl in a patient-controlled setting (patient-controlled analgesia, PCA).
  10. ncbi Dexmedetomidine and meperidine additively reduce the shivering threshold in humans
    Anthony G Doufas
    Outcomes Research Institute and the Department of Anesthesiology, Louisville, KY, USA
    Stroke 34:1218-23. 2003
    ..b>Meperidine and dexmedetomidine each linearly reduce the shivering threshold (triggering core temperature) with minimal ..
  11. ncbi Plasma concentrations of meperidine and normeperidine following continuous intrathecal meperidine in patients with neuropathic cancer pain
    J H Vranken
    Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acta Anaesthesiol Scand 49:665-70. 2005
    Intrathecal administration of meperidine, an opioid with local anesthetic activity, can induce analgesia in patients with intractable cancer pain...
  12. ncbi Physostigmine prevents postanesthetic shivering as does meperidine or clonidine
    E P Horn
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 88:108-13. 1998
    ..Accordingly, the authors tested the hypothesis that physostigmine administration inhibits postanesthetic shivering. Its efficacy was compared with that of saline (negative control) and meperidine and clonidine (positive controls).
  13. ncbi Maternal analgesia during labor disturbs newborn behavior: effects on breastfeeding, temperature, and crying
    A B Ransjö-Arvidson
    Division of Reproductive and Perinatal Health Care at the Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden
    Birth 28:5-12. 2001
    ....
  14. ncbi Disposition and clinical outcome after intraperitoneal meperidine and ropivacaine administration during laparoscopic surgery
    Michael J Paech
    Pharmacology and Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia
    Anesth Analg 106:278-86, table of contents. 2008
    Limited evidence supports the efficacy of intraperitoneal (IP) meperidine or local anesthetic for postoperative analgesia...
  15. ncbi Meperidine (Demerol) safety issues
    Christine Koczmara
    ISMP Canada
    Dynamics 16:8-12. 2005
  16. ncbi Ondansetron and meperidine prevent postoperative shivering after general anesthesia
    Masoud Entezari Asl
    Ardebil University of Medical Sciences, Iran
    Middle East J Anaesthesiol 21:67-70. 2011
    ..Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications. The aim of this study was to examine the preventive effects of Ondansetron and Meperidine on postoperative shivering.
  17. ncbi Meperidine, remifentanil and tramadol but not sufentanil interact with alpha(2)-adrenoceptors in alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knock out mice brain
    Jan Höcker
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Eur J Pharmacol 582:70-7. 2008
    ..Furthermore opioids like meperidine show potent anti-shivering effects like alpha(2)-adrenoceptor agonists...
  18. ncbi Effects of tramadol and meperidine on respiration, plasma catecholamine concentrations, and hemodynamics
    L H Mildh
    Department of Anesthesia, Helsinki University Hospital, Finland
    J Clin Anesth 11:310-6. 1999
    To evaluate the effects of high analgesic doses of tramadol and meperidine on respiration, plasma catecholamine concentrations, and hemodynamic parameters.
  19. ncbi Comparison of the effects of intravenous midazolam alone and in combination with meperidine on hemodynamic and respiratory responses and on patient compliance during upper gastrointestinal endoscopy: a randomized, double-blind trial
    A Melih Ozel
    Department of Gastroentorology, Gulhane Military Medical Academy, Haydarpafla Training Hospital, Istanbul, Turkey
    Turk J Gastroenterol 19:8-13. 2008
    ..during gastroscopy in healthy subjects and compared the changes with midazolam alone versus in combination with meperidine. The aim of this study was to evaluate if either method had any advantages or disadvantages with respect to ..
  20. ncbi Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study
    Zahid H Khan
    Department of Anesthesiology, Tehran University of Medical Science, Imam Khomeini Medical Center, Keshavarz Blvd, Tehran 1419733141, Iran
    Eur J Anaesthesiol 28:202-6. 2011
    Shivering causes various adverse disturbances and interferes with monitoring. The optimal dose of intrathecal meperidine to prevent shivering without producing other side-effects remains unknown...
  21. ncbi Comparison of dihydroergotamine with metoclopramide versus meperidine with promethazine in the treatment of acute migraine
    E R Scherl
    Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, USA
    Headache 35:256-9. 1995
    ..27 migraineurs into a prospective, randomized, double-blind study where each patient received either 75 mg meperidine with 25 mg promethazine IM or .5 mg dihydroergotamine with 10 mg metoclopramide IV...
  22. ncbi Comparison of intravenous ketorolac, meperidine, and both (balanced analgesia) for renal colic
    W H Cordell
    Emergency Medicine and Trauma Center, Methodist Hospital of Indiana, USA
    Ann Emerg Med 28:151-8. 1996
    ..the analgesic efficacy and safety of IV ketorolac, the only nonsteroidal antiinflammatory drug indicated for parenteral use in acute pain in the United States, with IV meperidine and with a combination of the two agents in renal colic.
  23. ncbi The effect of oral and subcutaneous meperidine on the maximal electroshock seizure (MES) in mice
    D O Yillar
    University of Istanbul, Cerrahpasa Medical Faculty, Department of Pharmacology and Clinical Pharmacology 34303 Cerrahpaşa, Istanbul, Turkey
    J Basic Clin Physiol Pharmacol 20:159-68. 2009
    The likely effect of oral and subcutaneous meperidine on maximal electroshock seizure (MES) in mice was studied. Convulsive current fifty (CC50) was assessed to be 46m A, an electrical pulse causing seizure in 50% of test animals...
  24. ncbi Cesarean delivery: a randomized trial of epidural analgesia versus intravenous meperidine analgesia during labor in nulliparous women
    Shiv K Sharma
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9068, USA
    Anesthesiology 96:546-51. 2002
    ..In this study, the authors compared epidural analgesia to intravenous meperidine analgesia using patient-controlled devices during labor to evaluate the effects of labor epidural analgesia, ..
  25. ncbi Meperidine and the management of pain: what you need to know
    Mary Todd
    PMSI
    Lippincotts Case Manag 9:241-2. 2004
  26. ncbi Prevalence of meperidine use in older surgical patients
    Benjamin S Kornitzer
    The Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Arch Surg 141:76-81. 2006
    The unique toxic and adverse effects of meperidine hydrochloride have prompted a number of expert panels convened by national health care policy organizations to recommend that meperidine not be used in older patients...
  27. ncbi Remifentanil versus meperidine for monitored anesthesia care: a comparison study in older patients undergoing ambulatory colonoscopy
    P E Greilich
    University of Texas Southwestern Medical Center Dallas, USA
    Anesth Analg 92:80-4. 2001
    ..This study was designed to test the hypothesis that a remifentanil infusion would be superior to boluses of meperidine in older patients undergoing ambulatory colonoscopy...
  28. ncbi Efficacy of tramadol versus meperidine for pain relief and safe recovery after adenotonsillectomy
    Z Ozer
    Department of Anaesthesiology and Reanimation, Mersin University Medical Faculty, Mersin, Turkey
    Eur J Anaesthesiol 20:920-4. 2003
    Adequate relief of pain after tonsillectomy is a common problem. We compared meperidine and tramadol when given at induction of anaesthesia with respect to their effects on postoperative pain relief and emergence characteristics after ..
  29. ncbi Pethidine--does familiarity or evidence perpetuate its use?
    Tamara Kredo
    Groote Schuur Hospital
    S Afr Med J 95:100-1. 2005
  30. ncbi Eliminating analgesic meperidine use with a supported formulary restriction
    Alec B O'Connor
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Med 118:885-9. 2005
    b>Meperidine is a commonly used analgesic despite unique disadvantages compared with other opioid analgesics...
  31. ncbi Preemptive peritonsillar ketamine infiltration: postoperative analgesic efficacy versus meperidine
    Mohamed Ibrahim El Sonbaty
    Faculty of Medicine, Cairo University, Cairo, Egypt
    Middle East J Anaesthesiol 21:43-51. 2011
    The current study was planned to assess post-tonsillectomy analgesic efficacy of pre-emptive peritonsillar ketamine infiltration with or without bupivacaine in comparison to meperidine alone or in combination with bupivacaine.
  32. ncbi Clinical trial: a randomized, study comparing meperidine (pethidine) and fentanyl in adult gastrointestinal endoscopy
    D J Robertson
    VA Medical Center, White River Junction, VT 05009, USA
    Aliment Pharmacol Ther 29:817-23. 2009
    There is little evidence to guide choice between meperidine (pethidine) and fentanyl for sedation for gastrointestinal endoscopy.
  33. ncbi A comparison of the local anesthetic effects of meperidine, fentanyl, and sufentanil on dorsal root axons
    R A Jaffe
    Department of Anesthesia, Stanford University School of Medicine, California 94305, USA
    Anesth Analg 83:776-81. 1996
    ..Clinically, both meperidine and sufentanil can produce segmental sensory anesthesia...
  34. ncbi A randomized study of combined spinal-epidural analgesia versus intravenous meperidine during labor: impact on cesarean delivery rate
    D R Gambling
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, USA
    Anesthesiology 89:1336-44. 1998
    ..This study compares the operative delivery rates associated with a CSE technique and those associated with intravenous meperidine for labor analgesia.
  35. ncbi Transient neurological symptoms after subarachnoid meperidine
    Wilfred R Lewis
    Department of Anesthesiology, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Anesth Analg 94:213-4, table of contents. 2002
    ..This syndrome has not been reported with the subarachnoid use of opioids. This case report describes TNS that occurred after administration of subarachnoid meperidine, an opioid with local anesthetic properties.
  36. ncbi Determinants of prescribing meperidine compared to morphine in hospitalized patients
    Mukta Panda
    Department of Medicine, University of Tennessee College of Medicine, Chattanooga Unit, 960 East Third Street, Chattanooga, TN 37403, USA
    Pain 110:337-42. 2004
    Morphine is a preferred narcotic since meperidine forms toxic metabolites. Determinants of meperidine use have been poorly described...
  37. pmc A prospective study of 2 sedation regimens in children: chloral hydrate, meperidine, and hydroxyzine versus midazolam, meperidine, and hydroxyzine
    Marianne M Sheroan
    University of Louisville School of Dentistry, Louisville, Kentucky, USA
    Anesth Prog 53:83-90. 2006
    ..to compare both the behavioral and physiological effects of 2 drug regimens in children: chloral hydrate (CH), meperidine (M), and hydroxyzine (H) (regimen A) versus midazolam (MZ), M, and H (regimen B)...
  38. ncbi Anesthetic efficacy of lidocaine/meperidine for inferior alveolar nerve blocks in patients with irreversible pulpitis
    Jason Bigby
    Department of Endodontics, College of Dentistry, The Ohio State University, Columbus, Ohio, USA
    J Endod 33:7-10. 2007
    ..single-blind study was to compare the anesthetic efficacy of lidocaine with epinephrine to lidocaine plus meperidine with epinephrine for inferior alveolar nerve blocks (IAN) in patients with mandibular posterior teeth ..
  39. ncbi Propofol versus midazolam/meperidine for outpatient colonoscopy: administration by nurses supervised by endoscopists
    Brian W Sipe
    Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis 46202, USA
    Gastrointest Endosc 55:815-25. 2002
    ..Propofol is under evaluation as a sedative for endoscopic procedures...
  40. ncbi Deep sedation occurs frequently during elective endoscopy with meperidine and midazolam
    Sandeep Patel
    Section of Endoscopy, Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44118, USA
    Am J Gastroenterol 100:2689-95. 2005
    ..The aims of this study were to prospectively evaluate the incidence and risk factors of deep sedation during elective endoscopy with meperidine and midazolam intended to maintain a level of moderate sedation.
  41. ncbi Buspirone and meperidine synergistically reduce the shivering threshold
    M Mokhtarani
    Department of Anesthesia, University of California, San Francisco, USA
    Anesth Analg 93:1233-9. 2001
    ..We tested the hypothesis that the combination of buspirone (a serotonin 1A partial agonist) and meperidine synergistically reduces the shivering threshold (triggering tympanic membrane temperature) to at least 34 ..
  42. ncbi Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype
    Koji Takada
    Department of Anesthesia, Toyonaka Municipal Hospital, Osaka, Japan
    Anesthesiology 96:1420-6. 2002
    The opioid agonist meperidine has actions, such as antishivering, that are more pronounced than those of other opioid agonists and that are not blocked with nonselective opioid antagonists...
  43. ncbi Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial
    John J Vargo
    Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Gastroenterology 123:8-16. 2002
    ..There has been no prospective, randomized comparison of gastroenterologist-administered propofol to meperidine and midazolam for endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography...
  44. ncbi Seizures in an Alzheimer's disease patient as a complication of colonoscopy premedication with meperidine
    Jerry Nagler
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Dig Dis Sci 53:62-4. 2008
    We describe the first reported case of generalized tonic-clonic seizures induced by meperidine premedication for a colonoscopy procedure in a 63-year-old woman with Alzheimer's disease...
  45. ncbi Remifentanil vs. meperidine for patient-controlled analgesia during colonoscopy: a randomized double-blind trial
    Lorella Fanti
    Department of Gastroenterology, Vita Salute University of Milano, IRCCS H San Raffaele, Milano, Italy
    Am J Gastroenterol 104:1119-24. 2009
    The aim was to compare patients' and endoscopists' satisfaction in terms of efficacy and safety of remifentanil patient-controlled analgesia (PCA) during colonoscopy with that of a combination of midazolam and meperidine.
  46. ncbi Propofol infusion versus intermittent meperidine and midazolam injection for conscious sedation in ERCP
    Pradermchai Kongkam
    Division of Gastroenterology, Department of Internal Medicine, Chulalongkorn University, Bangkok, Thailand
    J Gastrointestin Liver Dis 17:291-7. 2008
    ..This study was conducted to compare satisfaction, recovery score, and recovery/safety profiles for ERCP sedation between continuous infusion of propofol and conventional sedation...
  47. pmc The relative efficacy of meperidine for the treatment of acute migraine: a meta-analysis of randomized controlled trials
    Benjamin W Friedman
    Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Ann Emerg Med 52:705-13. 2008
    Despite guidelines recommending against opioids as first-line treatment for acute migraine, meperidine is the agent used most commonly in North American emergency departments...
  48. ncbi Intrathecal meperidine decreases shivering during cesarean delivery under spinal anesthesia
    Jean Denis Roy
    Département d Anesthésiologie, Hopital Maisonneuve Rosemont, Universite de Montreal, 5415 Boul l Assomption, Montreal, Quebec, Canada H1T 2M4
    Anesth Analg 98:230-4, table of contents. 2004
    ..We performed this prospective, double-blinded, and randomized study to determine whether intrathecal meperidine (0.2 mg/kg) decreases the incidence and intensity of shivering after spinal anesthesia for cesarean delivery...
  49. ncbi Bispectral index monitoring of conscious sedation with the combination of meperidine and midazolam during endoscopy
    Mohammed A Qadeer
    Section of Therapeutic Endoscopy, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 6:102-8. 2008
    ..Thus, we performed a prospective observational study to assess its ability for detecting deep sedation during endoscopy...
  50. ncbi The effect of meperidine and promethazine on fetal heart rate indices during the active phase of labor
    Ido Solt
    Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel
    Isr Med Assoc J 4:178-80. 2002
    ..Visual interpretation of fetal heart rare monitoring is subject to intra- and inter-observer variability...
  51. ncbi Intra-articular lidocaine versus intravenous meperidine/diazepam in anterior shoulder dislocation: a randomised clinical trial
    R Shariat Moharari
    Imam Khomeini Hospital, Medical Sciences University of Tehran, Tehran, Iran
    Emerg Med J 25:262-4. 2008
    ..Intravenous opiates and benzodiazepines are traditionally prescribed in order to relieve the pain in this group of patients; however, complications always pose a problem...
  52. ncbi Nurse-administered propofol sedation compared with midazolam and meperidine for EUS: a prospective, randomized trial
    John DeWitt
    Departments of Gastroenterology and Hepatology, Indiana University Medical Center and Regenstrief Institute, Inc, Indianapolis, Indiana, USA
    Gastrointest Endosc 68:499-509. 2008
    The utility of nurse-administered propofol sedation (NAPS) compared with midazolam and meperidine (M/M) for EUS is not known.
  53. ncbi Comparative study of intra-articular lidocaine and intravenous meperidine/diazepam for shoulder dislocations
    Michael Orlinsky
    Department of Emergency Medicine, LAC USC Medical Center, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Emerg Med 22:241-5. 2002
    ..purpose of this study was to compare the analgesic effectiveness of intra-articular lidocaine versus intravenous meperidine and diazepam during the reduction of anterior shoulder dislocations...
  54. ncbi Remifentanil by patient-controlled analgesia compared with intramuscular meperidine for pain relief in labour
    J A Thurlow
    Department of Anaesthesia, Southmead Hospital, Westbury on Trym, Bristol, UK
    Br J Anaesth 88:374-8. 2002
    ..The pharmacokinetics of remifentanil suggests that it may be suitable for analgesia during labour...
  55. ncbi The effect of meperidine-impregnated autogenous free fat grafts on postoperative pain management in lumbar disc surgery
    Erdal Kalkan
    Department of Neurosurgery, Faculty of Meram Medicine, Selcuk University, Konya, Turkey
    J Spinal Disord Tech 21:92-5. 2008
    ..Prospective, randomized, double-blind clinical study...
  56. ncbi Narcotic analgesic effects on the sphincter of Oddi: a review of the data and therapeutic implications in treating pancreatitis
    D R Thompson
    Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA
    Am J Gastroenterol 96:1266-72. 2001
    ..induces "spasm" in the sphincter of Oddi (SO) and should not be used in acute pancreatitis and that meperidine is the analgesic of choice because it does not elevate SO pressures...
  57. ncbi A dose-response study of intravenous regional anesthesia with meperidine
    S S Reuben
    Department of Anesthesiology, Baystate Medical Center, Springfield, Massachusetts 01199, USA
    Anesth Analg 88:831-5. 1999
    Intravenous regional anesthesia (IVRA) with meperidine in doses > or = 100 mg provides effective postoperative analgesia...
  58. ncbi Trends in medical use and abuse of opioid analgesics
    D E Joranson
    Pain and Policy Studies Group, Comprehensive Cancer Center, University of Wisconsin Medical School, Madison, USA
    JAMA 283:1710-4. 2000
    ..Although international and national expert groups have determined that opioid analgesics are essential for the relief of pain, little information has been available about the health consequences of the abuse of these drugs...
  59. ncbi Dexmedetomidine and meperidine prevent postanaesthetic shivering
    C Bicer
    Department of Anaesthesiology and Intensive Care, Erciyes University, Kayseri, Turkey
    Eur J Anaesthesiol 23:149-53. 2006
    This placebo-controlled study was performed to evaluate the efficacy of dexmedetomidine compared with meperidine and placebo in preventing postanaesthetic shivering.
  60. ncbi A comparison between meperidine, clonidine and urapidil in the treatment of postanesthetic shivering
    K R Schwarzkopf
    Department of Anesthesiology and Intensive Care Therapy, University Hospital, Jena, Germany
    Anesth Analg 92:257-60. 2001
    Postanesthetic shivering can be treated with many types of drugs. We compared the effects of meperidine, clonidine, and urapidil on postanesthetic shivering...
  61. ncbi Pethidine in emergency departments: promoting evidence-based prescribing
    Karen I Kaye
    NSW Therapeutic Advisory Group Inc, PO Box 766, Darlinghurst, Sydney, NSW 2010
    Med J Aust 183:129-33. 2005
    ..To reduce pethidine prescribing in hospital emergency departments (EDs)...
  62. ncbi A comparison of the effects of epidural and meperidine analgesia during labor on fetal heart rate
    James B Hill
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 102:333-7. 2003
    To estimate the effects of initiation of epidural analgesia on fetal heart rate (FHR) patterns compared with intravenous meperidine analgesia.
  63. ncbi Epidural analgesia and backache: a randomized controlled comparison with intramuscular meperidine for analgesia during labour
    B A Loughnan
    Departments of Anaesthesia and Obstetrics and Gynaecology, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Br J Anaesth 89:466-72. 2002
    ..Concern has been expressed that epidural analgesia for labour may be associated with a higher incidence of backache...
  64. ncbi Comparison of ondansetron and meperidine for prevention of shivering in patients undergoing spinal anesthesia
    Ebru Kelsaka
    Department of Anesthesiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey
    Reg Anesth Pain Med 31:40-5. 2006
    ..Regional anesthesia, like general anesthesia, influences the thermoregulatory process. The aim of our study was to compare the efficacy of ondansetron and meperidine in the prevention of shivering during and after spinal anesthesia.
  65. ncbi Meperidine for dystocia during the first stage of labor: A randomized controlled trial
    Claudio G Sosa
    Department of Obstetrics and Gynecology, Pereira Rossell Hospital, School of Medicine, University of Uruguay, Montevideo, Uruguay
    Am J Obstet Gynecol 191:1212-8. 2004
    This study was undertaken to evaluate whether the administration of meperidine decreases the length of labor in patients with a diagnosis of dystocia during the first stage of labor.
  66. ncbi Acupuncture during labor can reduce the use of meperidine: a controlled clinical study
    Britt Ingjerd Nesheim
    Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway
    Clin J Pain 19:187-91. 2003
    ..To evaluate the effectiveness of acupuncture as an analgesic during labor...
  67. ncbi Intravenous butorphanol, meperidine, and their combination relieve pain and distress in women in labor
    Kenneth E Nelson
    Section of Obstetric Anesthesia, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 102:1008-13. 2005
    ..The authors therefore studied, using validated intensity and affective scales and definitions of effective pain relief, the efficacy of intravenous meperidine, butorphanol, and their combination for labor analgesia.
  68. ncbi Propofol for endoscopic sedation: A protocol for safe and effective administration by the gastroenterologist
    Lawrence B Cohen
    Department of Medicine, The Mount Sinai School of Medicine, New York, New York 10021, USA
    Gastrointest Endosc 58:725-32. 2003
    ..A protocol was developed for administration of propofol, combined with small doses of midazolam and meperidine, for endoscopic sedation under the direction of a gastroenterologist...
  69. ncbi Magnesium sulfate increases the rate of hypothermia via surface cooling and improves comfort
    Richard M Zweifler
    University of South Alabama Stroke Center, Mobile, Ala 36617, USA
    Stroke 35:2331-4. 2004
    ..We assessed the hypothesis that the addition of intravenous MgSO4 to an antishivering pharmacological regimen increases the cooling rate when using a surface cooling technique...
  70. ncbi Reduction of pain on injection of propofol using meperidine and remifentanil
    G Basaranoglu
    Eur J Anaesthesiol 22:890-2. 2005
  71. ncbi Propofol versus midazolam plus meperidine for sedation during ambulatory esophagogastroduodenoscopy
    Vikram Khoshoo
    West Jefferson Medical Center, New Orleans, Louisiana, USA
    J Pediatr Gastroenterol Nutr 37:146-9. 2003
    To evaluate the efficacy and safety of propofol and meperidine plus midazolam for sedation during esophagogastroduodenoscopy (EGD) in children.
  72. ncbi Pethidine and skin warming to prevent shivering during endovascular cooling
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria
    Anaesth Intensive Care 32:362-7. 2004
    ..There were no significant complications arising from catheter placement. The combination of skin warming and pethidine was not reliable enough to be recommended for use during endovascular cooling in unanaesthetized patients...
  73. ncbi Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling
    M A De Georgia
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurology 63:312-7. 2004
    ..To report results of a randomized pilot clinical feasibility trial of endovascular cooling in patients with ischemic stroke...
  74. ncbi Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine
    Iman Saadawy
    Department of Anesthesia, Faculty of Medicine, Cairo University, Egypt
    Middle East J Anaesthesiol 19:631-44. 2007
    ..double blind study has been conducted to compare the analgesic efficacy of iv pretreatment of ketamine, meperidine, thiopental, lidocaine to minimize the injection pain of propofol...
  75. ncbi The comparison of midazolam and topical lidocaine spray versus the combination of midazolam, meperidine, and topical lidocaine spray to sedate patients for upper endoscopy
    L Laluna
    Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA
    Gastrointest Endosc 53:289-93. 2001
    ..the effectiveness of intravenous midazolam alone versus the combination of intravenous midazolam and intravenous meperidine for the sedation of patients undergoing upper endoscopy...
  76. ncbi A comparison of tramadol, amitriptyline, and meperidine for postepidural anesthetic shivering in parturients
    Y C Tsai
    Department of Anesthesiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Anesth Analg 93:1288-92. 2001
    ..b>Meperidine is often recommended for the treatment of postanesthetic shivering...
  77. ncbi Intrathecal meperidine for prevention of shivering during transurethral resection of prostate
    Maryam Davoudi
    Department of Anesthesiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
    Urol J 4:212-6. 2007
    The aim of this study was to investigate low-dose intrathecal meperidine for prevention or alleviation of shivering after induction of spinal anesthesia for transurethral resection of the prostate (TURP).
  78. ncbi The effect of intravenous administration of dexamethasone on postoperative pain, nausea, and vomiting after intrathecal injection of meperidine
    Ali Movafegh
    Department of Anesthesiology and Critical Care, Dr Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Anesth Analg 104:987-9. 2007
    ..Different drugs have been used to enhance postoperative neuraxial opioid analgesia and reduce adverse effects...
  79. pmc Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study
    Oliver Kimberger
    Department of Anaesthesiology, University of Bern, CH 3010 Bern, Switzerland
    Crit Care 11:R29. 2007
    ..b>Meperidine and skin warming each linearly lower vasoconstriction and shivering thresholds...
  80. ncbi The effects of meperidine and sufentanil on the shivering threshold in postoperative patients. pascal.alfonsi@apr.ap-hop-paris.fr
    P Alfonsi
    Department of Anesthesia, Hopital Ambroise Pare, Boulogne Billancourt, France
    Anesthesiology 89:43-8. 1998
    BACKGROUND. Meperidine (pethidine) reportedly treats postoperative shivering better than equianalgesic doses of other mu-receptor agonists...
  81. ncbi Periprostatic lidocaine infiltration and/or synthetic opioid (meperidine or tramadol) administration have no analgesic benefit during prostate biopsy. A prospective randomized double-blind placebo-controlled study comparing different methods
    Murat Bozlu
    Department of Urology, University of Mersin School of Medicine, Mersin, Turkey
    Urol Int 72:308-11. 2004
    ..To examine in a prospective, randomized, double-blind, placebo-controlled study the analgesic effect of periprostatic nerve block and/or intravenous synthetic opioid administration during a 12-core prostate biopsy...
  82. ncbi Midazolam with meperidine or fentanyl for colonoscopy: results of a randomized trial
    Bu Hussain Hayee
    Department of Gastroenterology, Queen Elizabeth National Health Service Trust, Woolwich, London, United Kingdom
    Gastrointest Endosc 69:681-7. 2009
    A combination of midazolam and opioid is usually used to achieve sedation and analgesia during colonoscopy. Two commonly used opioids are meperidine and fentanyl, but few studies have compared their efficacy.
  83. ncbi Moderate level sedation during endoscopy: a prospective study using low-dose propofol, meperidine/fentanyl, and midazolam
    Lawrence B Cohen
    Department of Medicine Gastroenterology, The Mount Sinai School of Medicine, New York, New York, USA
    Gastrointest Endosc 59:795-803. 2004
    ..However, its use generally has been limited to anesthesiologists because of the risks associated with deep sedation...
  84. ncbi Subarachnoid meperidine (Pethidine) causes significant nausea and vomiting during labor. The Duke Women's Anesthesia Research Group
    J V Booth
    Division of Women s Anesthesia, the Departments of Anesthesiology and Biostatistics, Duke University Medical Center, Durham, NC 27710, USA
    Anesthesiology 93:418-21. 2000
    ..In contrast, subarachnoid meperidine has been shown to provide a long duration of anesthesia in nonobstetric patients...
  85. ncbi Multifaceted education initiative minimizes pethidine prescribing in the emergency department
    Simone E Taylor
    Pharmacy Department, Austin Health, Victoria, Australia
    Emerg Med Australas 19:25-30. 2007
    ..Pain management experts have recommended a diminished role for pethidine because of lack of superiority for any indication and greater potential for adverse effects compared with morphine...
  86. ncbi Differential effects of alpha 2-adrenoceptors in the modulation of the thermoregulatory response in mice induced by meperidine
    Jan Höcker
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Anesthesiology 109:95-100. 2008
    b>Meperidine proved to be more effective in treatment of shivering than equianalgesic doses of other opioids, especially pure mu-agonists...
  87. ncbi Factors affecting outcomes in colonoscopy
    Seema Selehi
    West Midlands, University Hospitals Coventry, Department of Surgery, Walsgrave, United Kingdom
    Gastroenterol Nurs 31:56-63. 2008
    ..One hundred thirty-three participants (60.7%) had additional meperidine, with a completion rate of 94%. Eighty three participants (37...
  88. ncbi Influence of doxepin used in preemptive analgesia on the nociception in the perioperative period. Experimental and clinical study
    J Wordliczek
    Department of Anaesthesiology and Intensive Care, 1st Chair of General Surgery of Collegium Medicum, Jagiellonian University, , Poland
    Pol J Pharmacol 53:253-61. 2001
    ....
  89. ncbi Comparison of meperidine plus midazolam and fentanyl plus midazolam in procedural sedation: a double-blind, randomized controlled trial
    Suna Soysal
    Dokuz Eylul University Medical School, Emergency Department, Inciralti, 35340, Izmir, Turkey
    Adv Ther 21:312-21. 2004
    ..randomized, prospective study was conducted to compare the analgesic and sedative efficacy of fentanyl and meperidine in orthopedic closed reduction of fractures and dislocations undertaken in the emergency department...
  90. ncbi Postoperative effects of low-dose intrathecal morphine in coronary artery bypass surgery
    Davud Yapici
    Department of Anaesthesiology and Intensive Care, University of Mersin, Mersin 33079, Turkey
    J Card Surg 23:140-5. 2008
    ..The aim of this study was to evaluate the effects of 7 micro/kg intrathecal morphine administration in coronary bypass surgery in the postoperative period...
  91. ncbi [Utility of routine use of reversion after sedation in outpatient colonoscopy]
    O Alarcón Fernández
    Servicio de Aparato Digestivo, Red Hospiten Tenerife, Santa Cruz de Tenerife, Spain
    Gastroenterol Hepatol 28:10-4. 2005
    ..of flumazenil in reducing recovery time in the endoscopy unit after conscious sedation with midazolam and meperidine. However, its effectiveness in routine clinical practice has not been proved and therefore its use is debated.
  92. ncbi [Sedation in upper gastrointestinal endoscopy. Analysis of tolerance, complications and cost-effectiveness]
    C Ciriza de Los Ríos
    Servicio de Gastroenterologia, Hospital del Bierzo, Ponferrada, Leon, Spain
    Gastroenterol Hepatol 28:2-9. 2005
    ..Sedation of patients is an important complement to endoscopic procedures. The aim of this study was to analyze tolerance, complications and cost-effectiveness in patients undergoing diagnostic upper gastrointestinal endoscopy...
  93. ncbi Comparison of the analgesic efficacy of ketobemidone and morphine for management of postoperative pain in children: a randomized, controlled study
    L Jylli
    Pediatric Anesthesia and Intensive Care, Pain Treatment Service, Astrid Lindgren Children s Hospital, Karolinska Hospital, Department of Surgical Science, Karolinska Institutet, Stockholm, Sweden
    Acta Anaesthesiol Scand 48:1256-9. 2004
    ....
  94. ncbi Can facet joint infiltrative analgesia reduce postoperative pain in degenerative lumbar disc surgery?
    G Bademci
    Department of Neurosurgery, Faculty of Medicine, University of Kirikkale, Kirikkale, Turkey
    Neurocirugia (Astur) 19:45-9. 2008
    ..The purpose of this study was to evaluate its possible relation with the consumption of dolantine and analgesics and the facet-induced pain and postoperative pain score in degenerative disc surgery...
  95. ncbi Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone
    Mesut Sener
    Department of Anesthesiology and Reanimation, Baskent University Faculty of Medicine, Ankara, Turkey
    J Clin Anesth 20:103-8. 2008
    ..To compare the efficacy of injectable lornoxicam with diclofenac, ketoprofen, and dipyrone for acute postoperative pain...
  96. ncbi Comparison of satisfaction and pain relief between patients-controlled analgesia and interval analgesia after laparoscopic ovarian cystectomy
    Ulku Bayar
    Department of Obstetrics and Gynecology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
    J Psychosom Obstet Gynaecol 29:139-45. 2008
    ..sixteen women received morphine delivered by IV-PCA pump system and 15 women were prescribed another opioid (meperidine) intramuscularly...
  97. ncbi Remifentanil: a novel systemic analgesic for labor pain
    Shmuel Evron
    Department of Anesthesia, Wolfson Medical Center, Holon, Israel
    Anesth Analg 100:233-8. 2005
    ..in patient-controlled IV analgesia (PCIA) during labor and delivery with the effect of an IV infusion of meperidine. Eighty-eight healthy term parturients who requested IV analgesia for labor pain were enrolled in the study and ..
  98. ncbi Patient controlled analgesia for labour: a comparison of remifentanil with pethidine
    J M Blair
    St Helier Hospital, Epsom and St Helier University Hospitals NHS Trust, Wrythe Lane, Carshalton, Surrey SM5 1AA, UK
    Anaesthesia 60:22-7. 2005
    ..Neurologic and Adaptive Capacity Scores at 30 min were higher for remifentanil than for pethidine (median (interquartile range [range]) 36 (34.5-37 [32-39]) vs 34 (33-35 [30-35]), respectively; p = 0.003)...
  99. ncbi Post-thoracotomy pain and pulmonary function--comparison of intermittent intercostal bupivacaine vs intravenous pethidine
    Ali Ghafouri
    Department of General and Thoracic Surgery, Shariati Teaching Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Middle East J Anaesthesiol 19:767-80. 2008
    ..Because intravenous pethidine was used to supplement pain relief in the patients who received intercostal analgesia, total pethidine used was compared to that administered to patients in the intravenous pethidine group...
  100. ncbi Use of the infusion pain pump following transverse rectus abdominis muscle flap breast reconstruction
    Albert Losken
    Emory Division of Plastic and Reconstructive Surgery, Paces Plastic Surgery, Atlanta, GA 30308, USA
    Ann Plast Surg 54:479-82. 2005
    ..All patients received patient-controlled analgesia (PCA) (morphine, n = 34; meperidine (Demerol, Sanofi-Synthelabo), n = 1; hydromorphone hydrochloride (Dilaudid, Abbott Pharmaceutical) n = 1)...
  101. ncbi Effects of intraoperative i.v. acetaminophen vs i.m. meperidine on post-tonsillectomy pain in children
    J A Alhashemi
    Department of Anesthesia, King Abdulaziz Medical City, Jeddah, Saudi Arabia
    Br J Anaesth 96:790-5. 2006
    ..This randomized double-blind study compared the analgesic effects of i.v. acetaminophen and i.m. meperidine in paediatric patients undergoing tonsillectomy.

Research Grants27

  1. Exogenous Chemical Probes of TLR-Mediated Neuroinflammation
    HANG HUBERT YIN; Fiscal Year: 2013
    ..Evidence has accrued over the last seven years that glia are activated by opioids (e.g. morphine, methadone, meperidine, and oxycodone) and that this opioid-induced glial response suppresses opioid analgesia, resulting in the ..
  2. Mitochondrial dynamics underlie gene-environment interactions in Parkinson's
    Adrianne Chesser; Fiscal Year: 2013
    ..In particular, the meperidine-derivative MPTP and the herbicide paraquat (PQ) have been linked to a long term risk of developing symptoms of ..
  3. Breath Volatile Metabolites for the Diagnosis of Emerging Invasive Mold Infection
    Sophia Koo; Fiscal Year: 2013
    ..abstract_text> ..
  4. Harvard Medical School Vaccine Clinical Trials Unit
    Raphael Dolin; Fiscal Year: 2013
    ..Thus, 80 to 100 subjects will be followed at each CRS annually. We also anticipate that we could expand to enroll 500 subjects for a Phase III trial when one is undertaken. ..
  5. BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERS
    James Zacny; Fiscal Year: 2003
    ..to examine the degree to which a painful stimulus modulates the subjective and psychomotor effects of morphine, meperidine, butorphanol and nalbuphine...
  6. EFFICACY AND SAFETY OF NARCOTICS FOR PEDIATRIC SEDATION
    Paul Moore; Fiscal Year: 1990
    ..1. A dose-response analysis of intramuscular meperidine in a preschool pediatric dental population to determine its optimally safe and effective dose. 2...
  7. DRUG-INDUCED SHIVERING--EFFECTS OF A NURSING MEASURE
    BARBARA HOLTZCLAW; Fiscal Year: 1990
    ..Study variables are: 1) shivering on a scale of increasing extent shown by electromyography; 2) amount of meperidine to relieve shivering; 3) mean skin and core temperatures and 4) rate pressure product, derived from heart rate ..
  8. Role of Environment in Neuroprotection
    Richard Smeyne; Fiscal Year: 2005
    ..The cause of >90% of all PD cases are unknown. However, the discovery of the meperidine by-product 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has provided a useful model of Parkinsonism that ..
  9. CELLULAR TOXICOLOGY OF THE DOPAMINE NEURON
    Juan Sanchez Ramos; Fiscal Year: 1990
    ..Research proposed here concerns MPTP (l-methyl-4-phenyl-1,2,3,6- tetrahydropyridine), a meperidine analogue which produces changes that mimic the lesion of Parkinson's disease in primates and other species...
  10. NEURAL DEGENERATION BY TETRAHYDROPYRIDINE ANALOGS
    WILLIAM NICKLAS; Fiscal Year: 1992
    ..MPPP), a potent analgesic agent structurally similar to other widely used analgesics including meperidine. It is reported a few years ago that the ingestion of MPTP, mixed with varying amounts of MPPP and perhaps other ..
  11. (CHAVI) Center for HIV/AIDS Vaccine Immunology
    Barton Haynes; Fiscal Year: 2005
    ..It will address critical gaps in scientific knowledge and will contribute in a direct and meaningful fashion to the successful development of an efficacious and globally applicable HIV-1 vaccine. ..
  12. COMPARING THE EFFICACIES OF CONSCIOUS SEDATION DRUGS
    Stephen Cooper; Fiscal Year: 1980
    ..Both single entity agents such as diazepam and combination treatments such as diazepam plus meperidine will be evaluated.
  13. Cytokine-Augmented DNA Vaccine-Elicited Immunity to HIV
    DAN BAROUCH; Fiscal Year: 2005
    ..Raphael Dolin, Dean for Clinical Programs, Harvard Medical School, will guide Dr. Barouch's development as an independent investigator. In addition, a committee of distinguished scientists will oversee his progress toward independence. ..
  14. Nitrous Oxide and Wound Infections
    Ozan Akca; Fiscal Year: 2006
    ..Confirming our hypothesis would thus allow clinicians to make a minor modification in anesthetic practice that might reduce the incidence of a complication responsible for considerable perioperative morbidity and cost. ..
  15. Risk factors for medically indicated preterm birth in a Latin American population
    CLAUDIO GERARDO SOSA; Fiscal Year: 2010
    ..The long-term goal of this research program is to develop intervention strategies that are based on the risk factors identified in the proposed study resulting in decreased morbidity and mortality. ..
  16. SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONS
    Daniel Sessler; Fiscal Year: 2001
    ..Since the cost of oxygen is trivial and the risks of oxygen administration are low, clinicians will easily be able to implement this treatment once we have demonstrated its benefits. ..
  17. OPIOID RECEPTOR MECHANISMS
    John R Traynor; Fiscal Year: 2010
    ..An understanding of roles for RGS proteins in the actions of mu-opioids may lead to improvements in the treatment of pain as well as treatment of opioid and stimulant abuse. ..
  18. Novel Therapeutic Approaches for Narcotic Overdose
    PHILIP POTTER; Fiscal Year: 2009
    ..Overall, these studies should allow development of novel therapeutic approaches for the treatment of cocaine overdose. ..
  19. Role of Lipid Rafts in Adenylyl Cyclase Sensitization
    John Traynor; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  20. Maternal Separation: Rat Model of Opioid Vulnerability
    STEPHEN HOLTZMAN; Fiscal Year: 2006
    ..abstract_text> ..
  21. SELECTIVE THERAPY OF TUMORS THAT OVEREXPRESS C MYC
    PHILIP POTTER; Fiscal Year: 2006
    ..These studies will assess the effectiveness of VDEPT with rCE or hiCE and CPT-11 at eliminating tumor cells from appropriate animal models of human disease. ..
  22. Role of Angiogenesis Following Stroke
    Patrick Lyden; Fiscal Year: 2006
    ..abstract_text> ..
  23. HEALTH/SAFETY IMPACT OF ONTARIOS DRINKING HOURS
    Evelyn Vingilis; Fiscal Year: 2001
    ..Alcohol-related casualties for both cities will be subjected to time-series analyses. In addition, Detroit data will be disaggregated to analyze the trends of alcohol-related casualties involving Ontario drivers. ..
  24. BEHAVIORAL PHARMACOLOGY OF OPIOIDS
    STEPHEN HOLTZMAN; Fiscal Year: 2004
    ....
  25. BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS
    STEPHEN HOLTZMAN; Fiscal Year: 2002
    ..Acute agonist-induced sensitization to opioid antagonists appears to be an exquisite example of neuronal plasticity, reflecting the first hours of the drug-receptor interactions that lead to chronic physical dependence upon opioids. ..
  26. Sex Diffrerences in Opioid Antinociception
    Andrew Barrett; Fiscal Year: 2003
    ....