cocaine

Summary

Summary: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Top Publications

  1. ncbi Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    B Giros
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 379:606-12. 1996
  2. pmc Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Brain Res Rev 56:27-78. 2007
  3. pmc Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
    Mary Kay Lobo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 330:385-90. 2010
  4. pmc High impulsivity predicts the switch to compulsive cocaine-taking
    David Belin
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 320:1352-5. 2008
  5. pmc microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs
    Jodi E Eipper-Mains
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    RNA 17:1529-43. 2011
  6. ncbi Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area
    Manuel Mameli
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Nat Neurosci 14:414-6. 2011
  7. ncbi Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine
    Stephanie L Borgland
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
    Neuron 49:589-601. 2006
  8. ncbi Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression
    Camilla Bellone
    Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH 1211 Geneva, Switzerland
    Nat Neurosci 9:636-41. 2006
  9. ncbi Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
    M A Ungless
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California 94110, USA
    Nature 411:583-7. 2001
  10. pmc Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
    KELLY L CONRAD
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Nature 454:118-21. 2008

Research Grants

Detail Information

Publications315 found, 100 shown here

  1. ncbi Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    B Giros
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 379:606-12. 1996
    ..The dopamine transporter is an obligatory target of cocaine and amphetamine, as these psychostimulants have no effect on locomotor activity or dopamine release and uptake in ..
  2. pmc Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Brain Res Rev 56:27-78. 2007
    ..These findings complement the recent behavioral findings that cocaine and amphetamine are more rewarding when administered into the ventromedial striatum than into the ventrolateral ..
  3. pmc Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
    Mary Kay Lobo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 330:385-90. 2010
    The nucleus accumbens is a key mediator of cocaine reward, but the distinct roles of the two subpopulations of nucleus accumbens projection neurons, those expressing dopamine D1 versus D2 receptors, are poorly understood...
  4. pmc High impulsivity predicts the switch to compulsive cocaine-taking
    David Belin
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 320:1352-5. 2008
    ..We report here that, whereas high reactivity to novelty predicts the propensity to initiate cocaine self-administration, high impulsivity predicts the development of addiction-like behavior in rats, including ..
  5. pmc microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs
    Jodi E Eipper-Mains
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    RNA 17:1529-43. 2011
    ..we cataloged miRNA expression in the nucleus accumbens and at striatal synapses in control and chronically cocaine-treated mice...
  6. ncbi Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area
    Manuel Mameli
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Nat Neurosci 14:414-6. 2011
    The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine ..
  7. ncbi Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine
    Stephanie L Borgland
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
    Neuron 49:589-601. 2006
    ..Furthermore, in vivo administration of an orexin 1 receptor antagonist blocks locomotor sensitization to cocaine and occludes cocaine-induced potentiation of excitatory currents in VTA dopamine neurons...
  8. ncbi Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression
    Camilla Bellone
    Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH 1211 Geneva, Switzerland
    Nat Neurosci 9:636-41. 2006
    ..Using an 'ex vivo' approach in mice, we show that a single injection of cocaine caused strong rectification and conferred sensitivity to the polyamine Joro spider toxin (JST) of AMPAR-mediated ..
  9. ncbi Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
    M A Ungless
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California 94110, USA
    Nature 411:583-7. 2001
    ..Here we show that a single in vivo exposure to cocaine induces long-term potentiation of AMPA (alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid)-receptor-..
  10. pmc Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
    KELLY L CONRAD
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Nature 454:118-21. 2008
    Relapse to cocaine use after prolonged abstinence is an important clinical problem. This relapse is often induced by exposure to cues associated with cocaine use...
  11. ncbi Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol
    Jesus Bertran-Gonzalez
    Inserm UMR S 839, Paris, France
    J Neurosci 28:5671-85. 2008
    ..Acute cocaine treatment increased phosphorylation of ERK and its direct or indirect nuclear targets, mitogen- and stress-..
  12. pmc Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1137-43. 2010
    ..We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use and chronic social defeat stress...
  13. ncbi Evidence for addiction-like behavior in the rat
    Véronique Deroche-Gamonet
    INSERM U588, Laboratoire de Physiopathologie des Comportements, Bordeaux Institute for Neurosciences, University Victor Segalen Bordeaux 2, Domaine de Carreire, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Science 305:1014-7. 2004
    ..three of the essential diagnostic criteria for addiction appear over time in rats trained to self-administer cocaine. As in humans, this addiction-like behavior is present only in a small proportion of subjects using cocaine and ..
  14. ncbi Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
    Arvind Kumar
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Neuron 48:303-14. 2005
    Given that cocaine induces neuroadaptations through regulation of gene expression, we investigated whether chromatin remodeling at specific gene promoters may be a key mechanism...
  15. pmc Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA
    Billy T Chen
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
    Neuron 59:288-97. 2008
    ..Here, we show that self-administration of cocaine, but not passive cocaine infusions, produced a persistent potentiation of VTA excitatory synapses, which was ..
  16. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
    ..We report here that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine (DA) function before drug exposure...
  17. pmc A translational profiling approach for the molecular characterization of CNS cell types
    Myriam Heiman
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065, USA
    Cell 135:738-48. 2008
    ....
  18. pmc Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 31:5737-43. 2011
    Repeated noncontingent cocaine injections, which lead to behavioral sensitization, increase AMPA receptor (AMPAR) transmission in the rodent nucleus accumbens (NAc) in a withdrawal-dependent manner...
  19. pmc Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine
    Stefania Fasano
    Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Foundation and University, Milano, Italy
    Biol Psychiatry 66:758-68. 2009
    ..activator of Ras-ERK signaling, is a likely candidate for coupling these neurotransmitter signals to ERK kinases in the striatonigral medium spiny neurons (MSN) and for modulating behavioral responses to drug abuse such as cocaine.
  20. ncbi Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc
    Manuel Mameli
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Nat Neurosci 12:1036-41. 2009
    ..In the ventral tegmental area (VTA), a single exposure to cocaine efficiently triggers NMDA receptor-dependent synaptic plasticity in DA neurons, whereas plasticity in the nucleus ..
  21. pmc Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area
    Emanuela Argilli
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:9092-100. 2008
    ..Even a single exposure to cocaine in naive animals is sufficient to trigger sustained changes on VTA glutamatergic synapses that resemble activity-..
  22. pmc MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212
    Heh In Im
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida, USA
    Nat Neurosci 13:1120-7. 2010
    ..b>Cocaine addiction is commonly viewed as a disorder of neuroplasticity, but the potential involvement of MeCP2 has not ..
  23. ncbi Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
    David Belin
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Neuron 57:432-41. 2008
    ..We have investigated the functional significance of this circuitry in the control over a cocaine-seeking habit by using an intrastriatal disconnection procedure that combined a selective, unilateral lesion of ..
  24. pmc Cholinergic interneurons control local circuit activity and cocaine conditioning
    Ilana B Witten
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Science 330:1677-81. 2010
    ..Furthermore, these neurons could be activated by cocaine, and silencing this drug-induced activity during cocaine exposure (despite the fact that the manipulation of the ..
  25. pmc Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens
    Brad A Grueter
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Neurosci 13:1519-25. 2010
    ....
  26. ncbi microRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity
    Vijay Chandrasekar
    Division of Biochemistry, Department of Medicine, University of Fribourg, Rue du Musee 5, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Mol Cell Neurosci 42:350-62. 2009
    ..MicroRNA profiling for identifying miRNAs regulating cocaine-induced, plasticity-related genes revealed significant regulation of a set of miRNAs upon cocaine administration, ..
  27. pmc Epigenetic inheritance of a cocaine-resistance phenotype
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Neurosci 16:42-7. 2013
    We delineated a heritable phenotype resulting from the self-administration of cocaine in rats...
  28. pmc Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use
    Ingo Willuhn
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:20703-8. 2012
    ..v. catheters over the course of 3 wk of cocaine self-administration...
  29. ncbi Involvement of the dorsal striatum in cue-controlled cocaine seeking
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:8665-70. 2005
    ..Nucleus accumbens dopamine (DA) neurotransmission plays an important role in the reinforcing effect of cocaine itself, but, unlike nucleus accumbens glutamate, it seems not to mediate the conditioned reinforcing properties ..
  30. ncbi Differential roles of the dorsolateral and midlateral striatum in punished cocaine seeking
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 32:4645-50. 2012
    ..that the sensorimotor striatum, a structure that mediates habitual drug seeking, also mediates punished cocaine seeking...
  31. pmc Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine
    Said Kourrich
    Cellular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Cell 152:236-47. 2013
    ..However, the brain site of action and underlying cellular mechanisms remain unidentified. We found that cocaine exposure triggers a Sig-1R-dependent upregulation of D-type K(+) current in the nucleus accumbens (NAc) that ..
  32. pmc How addictive drugs disrupt presynaptic dopamine neurotransmission
    David Sulzer
    Departments of Psychiatry, Neurology, and Pharmacology, Columbia University Medical Center, Black 308, 650 W 168 St, New York, NY 10032, USA
    Neuron 69:628-49. 2011
    ....
  33. ncbi Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 14:684-90. 2011
    ..or -VTA administration of the orexin-1 receptor (OrxR1) antagonist SB-334867 on discriminative cue-induced cocaine-seeking...
  34. pmc Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 30:7984-92. 2010
    ..Rats were either extinguished or withdrawn without extinction training (abstinence) from cocaine self-administration, and measurements of postsynaptic density proteins in the core and shell subcompartments of ..
  35. ncbi Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
    Dopamine is an important mediator of the reinforcing effects of cocaine, and alterations in dopamine function might be involved in cocaine dependence...
  36. pmc The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system
    Rodrigo A Espana
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Eur J Neurosci 31:336-48. 2010
    ..examined the extent to which hypocretin neurotransmission regulates behavioral and neurochemical responses to cocaine, and behavioral responses to food reinforcement...
  37. pmc A silent synapse-based mechanism for cocaine-induced locomotor sensitization
    Travis E Brown
    Washington State University, Pullman, Washington 99164 6520, USA
    J Neurosci 31:8163-74. 2011
    ..is a common and robust behavioral alteration in rodents whereby following exposure to abused drugs such as cocaine, the animal becomes significantly more hyperactive in response to an acute drug challenge...
  38. pmc The role of glutamate receptor redistribution in locomotor sensitization to cocaine
    Carrie R Ferrario
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064 3095, USA
    Neuropsychopharmacology 35:818-33. 2010
    ..receptor (AMPAR) surface expression in the nucleus accumbens (NAc) is enhanced after withdrawal from repeated cocaine exposure...
  39. ncbi Cyclic adenosine monophosphate-independent tyrosine phosphorylation of NR2B mediates cocaine-induced extracellular signal-regulated kinase activation
    Vincent Pascoli
    Centre National de la Recherche Scientifique Unite Mixte de Recherche, Paris, France
    Biol Psychiatry 69:218-27. 2011
    ..In response to cocaine, ERK phosphorylation (i.e...
  40. ncbi Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli
    William Renthal
    Department of Psychiatry and Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuron 56:517-29. 2007
    ..Chronic, but not acute, exposure to cocaine or stress decreases HDAC5 function in the nucleus accumbens (NAc), a major brain reward region, which allows for ..
  41. ncbi Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens
    Amy C Boudreau
    Department of Neuroscience, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurosci 25:9144-51. 2005
    ..AMPA receptors in nucleus accumbens (NAc) tissue obtained from rats treated repeatedly with saline or cocaine. Surface/intracellular (S/I) ratios for glutamate receptor 1 (GluR1) and GluR2/3 subunits were increased 21 d ..
  42. pmc Essential role of the histone methyltransferase G9a in cocaine-induced plasticity
    Ian Maze
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Science 327:213-6. 2010
    b>Cocaine-induced alterations in gene expression cause changes in neuronal morphology and behavior that may underlie cocaine addiction...
  43. ncbi Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA
    J Neurosci 26:6583-8. 2006
    ..Here we test whether dopamine increases occur to conditioned stimuli in human subjects addicted to cocaine and whether this is associated with drug craving...
  44. pmc Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference
    Elisabet Jerlhag
    Section for Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, SE 405 30, Gothenburg, Sweden
    Psychopharmacology (Berl) 211:415-22. 2010
    ..reward pathway that is intimately associated with reward-seeking behaviour, we sought to determine whether the central ghrelin signaling system is required for reward from drugs of abuse other than alcohol, namely cocaine or amphetamine.
  45. pmc Cocaine regulates MEF2 to control synaptic and behavioral plasticity
    Suprabha Pulipparacharuvil
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9127, USA
    Neuron 59:621-33. 2008
    Repeated exposure to cocaine causes sensitized behavioral responses and increased dendritic spines on medium spiny neurons of the nucleus accumbens (NAc)...
  46. ncbi CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking
    Sharon M Anderson
    Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, L603, Boston, Massachusetts 02118, USA
    Nat Neurosci 11:344-53. 2008
    ..in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse...
  47. pmc Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving
    Lin Lu
    National Institute on Drug Dependence, Peking University, Beijing, China
    Biol Psychiatry 66:137-45. 2009
    ..area (VTA) brain-derived neurotrophic factor (BDNF) contributes to time-dependent increases in cue-induced cocaine seeking after withdrawal (incubation of cocaine craving)...
  48. pmc Individual variation in the motivational properties of cocaine
    Benjamin T Saunders
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Neuropsychopharmacology 36:1668-76. 2011
    ..Moreover, a discrete cocaine cue also acquires greater motivational control over behavior in rats prone to attribute incentive salience to a ..
  49. ncbi Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking
    Billy T Chen
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    Nature 496:359-62. 2013
    ..chronic drug use compromises cortical activity and, equally important, whether this deficit promotes compulsive cocaine seeking...
  50. pmc Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
    Benjamin Boutrel
    Center for Psychiatric Neuroscience and Service Universitaire de Psychiatrie de l Enfant et de l Adolescent, Centre Hospitalier Universitaire Vaudois Département de Psychiatrie, University of Lausanne, Prilly, Switzerland
    Proc Natl Acad Sci U S A 102:19168-73. 2005
    ..Here we show that intracerebroventricular infusions of Hcrt-1 lead to a dose-related reinstatement of cocaine seeking without altering cocaine intake in rats...
  51. pmc DNA methylation regulates cocaine-induced behavioral sensitization in mice
    Kaili Anier
    Department of Pharmacology, University of Tartu, Tartu, Estonia
    Neuropsychopharmacology 35:2450-61. 2010
    The behavioral sensitization produced by repeated cocaine treatment represents the neural adaptations underlying some of the features of addiction in humans...
  52. pmc In vivo cocaine experience generates silent synapses
    Yanhua H Huang
    Program in Neuroscience, Washington State University, Pullman, WA 99164 6520, USA
    Neuron 63:40-7. 2009
    ..Here, we demonstrate that highly salient in vivo experience, such as exposure to cocaine, generates silent synapses in the nucleus accumbens (NAc) shell, a key brain region mediating addiction-related ..
  53. pmc Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered activation of mitogen-activated protein kinases
    Amy C Boudreau
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurosci 27:10621-35. 2007
    ..report increased responsiveness of nucleus accumbens (NAc) AMPA receptors (AMPARs) after withdrawal from repeated cocaine treatment, others report decreased responsiveness after withdrawal plus cocaine challenge...
  54. pmc mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration
    Richard M Cleva
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, SC, USA
    Behav Neurosci 125:10-9. 2011
    ..positive allosteric modulator 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) on the extinction of cocaine-seeking behavior in rats with a history of intravenous cocaine self-administration...
  55. ncbi Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice
    Karen Brami-Cherrier
    Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, Unite Mixte de Recherche 7102, 75005 Paris, France
    J Neurosci 25:11444-54. 2005
    ..kinase (ERK) is critical for the expression of immediate-early genes in the striatum in response to cocaine and Delta9-tetrahydrocannabinol and for the rewarding properties of these drugs...
  56. pmc Regulation of MiR-124, Let-7d, and MiR-181a in the accumbens affects the expression, extinction, and reinstatement of cocaine-induced conditioned place preference
    Vijay Chandrasekar
    Division of Biochemistry, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Neuropsychopharmacology 36:1149-64. 2011
    ..We have previously shown that chronic cocaine suppresses miR-124 and let-7d and induces the expression of miR-181a in mesolimbic pathway...
  57. pmc Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors
    Estefanía P Bello
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Neurosci 14:1033-8. 2011
    ..displayed elevated DA synthesis and release, hyperlocomotion and supersensitivity to the psychomotor effects of cocaine. The mice also exhibited increased place preference for cocaine and enhanced motivation for food reward...
  58. ncbi Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour
    Vincent Pascoli
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
    Nature 481:71-5. 2012
    ..Mechanistic investigations start with the identification of the molecular drug targets. Cocaine, for example, exerts its reinforcing and early neuroadaptive effects by inhibiting the dopamine transporter, thus ..
  59. ncbi Drug seeking becomes compulsive after prolonged cocaine self-administration
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 305:1017-9. 2004
    ..Presentation of an aversive conditioned stimulus suppressed drug seeking in rats with limited cocaine self-administration experience, but no longer did so after an extended cocaine-taking history...
  60. pmc Cocaine-induced potentiation of synaptic strength in dopamine neurons: behavioral correlates in GluRA(-/-) mice
    Y Dong
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Proc Natl Acad Sci U S A 101:14282-7. 2004
    ..Here, we show that both the cocaine- and stress-induced synaptic enhancement involves an up-regulation of alpha-amino-3-hydroxy-5-methyl-4-..
  61. pmc AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine
    Marina E Wolf
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, United States
    Neurosci Biobehav Rev 35:185-211. 2010
    This review focuses on cocaine-induced postsynaptic plasticity in the nucleus accumbens (NAc) involving changes in AMPA receptor (AMPAR) transmission. First, fundamental properties of AMPAR in the NAc are reviewed...
  62. ncbi Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving
    Jeffrey W Grimm
    Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:742-7. 2003
    Using a rat model of drug craving, we found that the responsiveness to cocaine cues progressively increases or incubates over the first 60 d of cocaine withdrawal...
  63. pmc Distinct patterns of DeltaFosB induction in brain by drugs of abuse
    L I Perrotti
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Synapse 62:358-69. 2008
    ..We also extended previous research involving cocaine, morphine, and nicotine to two additional drugs of abuse, ethanol and Delta(9)-tetrahydrocannabinol (Delta(9)-THC,..
  64. ncbi Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB1 1BB, UK
    Nat Neurosci 7:389-97. 2004
    ..Here we show a neural double-dissociation of the behavioral processes that underlie cocaine self-administration in rats...
  65. ncbi Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine
    M J Thomas
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Neurosci 4:1217-23. 2001
    ..transmission in NAc slices prepared from animals displaying sensitization 10-14 days after repeated in vivo cocaine exposure...
  66. ncbi Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens
    Said Kourrich
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:7921-8. 2007
    ..progression of bidirectional changes in glutamatergic synaptic strength occurs after repeated in vivo exposure to cocaine. During a protracted drug-free period, NAc neurons from cocaine-experienced mice develop a robust potentiation of ..
  67. pmc Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens
    Ko Woon Lee
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:3399-404. 2006
    ..In the present study, we analyzed dendritic spine density after chronic cocaine treatment in distinct D1 or D2 receptor-containing medium-sized spiny neurons in NAcc...
  68. ncbi Transition to addiction is associated with a persistent impairment in synaptic plasticity
    Fernando Kasanetz
    INSERM U862, Neurocentre Magendie, 147 Rue Léo Saignat, 33077, Bordeaux Cedex, France
    Science 328:1709-12. 2010
    ..However, the neurobiological adaptations specifically associated with the transition to addiction are unknown. Cocaine self-administration rapidly suppresses long-term depression (LTD), an important form of synaptic plasticity in ..
  69. pmc Striatal microRNA controls cocaine intake through CREB signalling
    Jonathan A Hollander
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA
    Nature 466:197-202. 2010
    b>Cocaine addiction is characterized by a gradual loss of control over drug use, but the molecular mechanisms regulating vulnerability to this process remain unclear...
  70. ncbi Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 386:830-3. 1997
    b>Cocaine blocks the reuptake of dopamine, a neurotransmitter involved in the control of movement, cognition, motivation and reward...
  71. pmc Cocaine self-administration produces a persistent increase in dopamine D2 High receptors
    Lisa A Briand
    Neuroscience Program, The University of Michigan, United States
    Eur Neuropsychopharmacol 18:551-6. 2008
    b>Cocaine addicts are reported to have decreased numbers of striatal dopamine D2 receptors...
  72. pmc Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine
    Ghazaleh Sadri-Vakili
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129 4404, USA
    J Neurosci 30:11735-44. 2010
    b>Cocaine self-administration alters patterns of gene expression in the brain that may underlie cocaine-induced neuronal plasticity. In the present study, male Sprague Dawley rats were allowed to self-administer cocaine (0...
  73. pmc Psychological stress, cocaine and natural reward each induce endoplasmic reticulum stress genes in rat brain
    A A Pavlovsky
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Neuroscience 246:160-9. 2013
    ..However, presently the full extent of ER stress responses to psychological stress or cocaine, and which of the three ER stress pathways is activated is unknown...
  74. pmc Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use
    Roland Bock
    Laboratory for Integrative Neuroscience, National Institute of Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 16:632-8. 2013
    ..loss of control over drug intake, which is seen in only a fraction of those exposed to stimulant drugs such as cocaine. The cellular mechanisms underlying vulnerability or resistance to compulsive drug use remain unknown...
  75. pmc Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Nat Neurosci 15:891-6. 2012
    Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown...
  76. ncbi Silent myocardial damage in cocaine addicts
    Giovanni Donato Aquaro
    UO Risonanza Magnetica and UO Malattie cardiovascolari, Fondazione G Monasterio Regione Toscana CNR, Pisa, Italy
    Heart 97:2056-62. 2011
    b>Cocaine addiction is associated with either ischaemic or non-ischaemic cardiac complications...
  77. pmc Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell
    Ryan T Lalumiere
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Eur J Neurosci 35:614-22. 2012
    Following cocaine self-administration and extinction training, activity in the infralimbic cortex (IL) suppresses cocaine-seeking behavior...
  78. pmc D-cycloserine reduces the context specificity of pavlovian extinction of cocaine cues through actions in the nucleus accumbens
    Mary M Torregrossa
    Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    J Neurosci 30:10526-33. 2010
    ..hypothesis that d-cycloserine (DCS), which enhances extinction in other procedures, would enhance extinction of cocaine-associated cues in a novel context to reduce cue-induced reinstatement...
  79. ncbi Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Neuron 47:795-801. 2005
    ..into the basolateral amygdala, prior to the reactivation of a well-learned memory for a conditioned stimulus (CS)-cocaine association, abolishes the acquired conditioned reinforcing properties of the drug-associated stimulus and thus ..
  80. ncbi Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses
    Ju Wang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Mol Neurobiol 44:269-86. 2011
    ..patterns in animal or human brain tissues after the administration of alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine/heroin/butorphanol, or nicotine...
  81. ncbi Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi
    Kimberly A Badanich
    Department of Psychology, Cognitive and Neural Sciences, University of South Florida 4202 E Fowler Avenue Tampa, FL 33620, USA
    Eur J Pharmacol 550:95-106. 2006
    ..b>Cocaine conditioned place preferences were measured in early adolescent [postnatal day (PND) 35], late adolescent (PND 45)..
  82. pmc A role for repressive histone methylation in cocaine-induced vulnerability to stress
    Herbert E Covington
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1065, New York, NY 10029, USA
    Neuron 71:656-70. 2011
    ..histone methylation in nucleus accumbens (NAc), an important brain reward region, as a key mechanism linking cocaine exposure to increased stress vulnerability...
  83. pmc Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 31:14536-41. 2011
    Following prolonged withdrawal from extended access cocaine self-administration in adult rats, high conductance Ca2+ -ermeable AMPA receptors (CP-AMPARs) accumulate in nucleus accumbens (NAc) synapses and mediate the expression of "..
  84. pmc AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine reward
    Said Kourrich
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurosci 32:6578-86. 2012
    ..with doxycycline eliminates both the IA-mediated firing decrease and the elevated behavioral response to cocaine. This study identifies CaMKII regulation of IA in NAc shell neurons as a novel cellular contributor to the ..
  85. pmc Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs
    Martin J Hicks
    Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Mol Ther 19:612-9. 2011
    Based on the concept that anticocaine antibodies could prevent inhaled cocaine from reaching its target receptors in the brain, an effective anticocaine vaccine could help reverse cocaine addiction...
  86. ncbi Cocaine self-administration alters the expression of chromatin-remodelling proteins; modulation by histone deacetylase inhibition
    Lionel Host
    INSERM, U575, Centre de Neurochimie, Universite de Strasbourg, Strasbourg, France
    J Psychopharmacol 25:222-9. 2011
    ..histone deacetylases inhibitor trichostatin A to rats has been shown to decrease the reinforcing properties of cocaine. In the present study, we investigated alterations in gene expression patterns in the anterior cingulate cortex, ..
  87. pmc Behavioral and morphological responses to cocaine require kalirin7
    Drew D Kiraly
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA
    Biol Psychiatry 68:249-55. 2010
    ..in dendritic spine density and gene expression in the nucleus accumbens and in the ambulatory response to cocaine occur following chronic cocaine treatment...
  88. ncbi Protein kinase mζ is necessary for cocaine-induced synaptic potentiation in the ventral tegmental area
    Shih Yin Ho
    Department of Biological Sciences, National Sun Yat Sen University, No 70 Lein Hai Road, Kaohsiung, Taiwan
    Biol Psychiatry 71:706-13. 2012
    ..has been made in our understanding of brain regions and specific receptors that are involved in the action of cocaine addiction...
  89. ncbi Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites
    Y Itzhak
    Department of Biochemistry and Molecular Biology R 629, University of Miami School of Medicine, P O Box 016129, Miami, FL 33101, USA
    Brain Res 818:204-11. 1999
    We investigated if repeated administration of cocaine, nicotine, dizocipline (MK-801) and alcohol yields behavioral cross-sensitization between these agents...
  90. pmc Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams
    M S McMurray
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Stress 11:398-410. 2008
    Gestational cocaine treatment results in significantly increased maternal aggression towards an intruder by postpartum day six, while acute postpartum treatment dose dependently decreases maternal aggressive (MA) behavior...
  91. ncbi Concurrent activation of dopamine D1 and D2 receptors is required to evoke neural and behavioral phenotypes of cocaine sensitization
    Christine Capper-Loup
    Department of Neurology, University Hospital, 3010 Bern, Switzerland
    J Neurosci 22:6218-27. 2002
    ..and compared the responses of drug-naive rats with those of rats given previous intermittent treatment with cocaine. In rats exposed to repeated cocaine treatment, the effects of a subsequent challenge treatment with either a D1-..
  92. pmc Maternal cocaine use: estimated effects on mother-child play interactions in the preschool period
    Arnise L Johnson
    Department of Pediatrics, School of Medicine, University of Miami School of Medicine, Florida 33101, USA
    J Dev Behav Pediatr 23:191-202. 2002
    ..was to evaluate the quality of parent-child interactions in preschool-aged children exposed prenatally to cocaine. African-American mothers and their full-term newborns (n = 343) were enrolled prospectively at birth and ..
  93. pmc Brain-derived neurotrophic factor and cocaine addiction
    Jacqueline F McGinty
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave MSC 510, Charleston, SC 29425, USA
    Brain Res 1314:183-93. 2010
    The effects of brain-derived neurotrophic factor (BDNF) on cocaine-seeking are brain region-specific...
  94. pmc Cocaine sensitization and reward are under the influence of circadian genes and rhythm
    Carolina Abarca
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Proc Natl Acad Sci U S A 99:9026-30. 2002
    ..melanogaster have shown that the circadian clock gene period (Per) can influence behavioral responses to cocaine. Here we show that the mouse homologues of the Drosophila Per gene, mPer1 and mPer2, modulate cocaine ..
  95. ncbi The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
    K McFarland
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 21:8655-63. 2001
    The role of limbic-striato-pallidal circuitry in cocaine-induced reinstatement was evaluated...
  96. ncbi Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine
    T E Robinson
    Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
    Eur J Neurosci 11:1598-604. 1999
    ..Rats were given repeated injections of either amphetamine or cocaine, or, to control for general motor activity, allowed access to a running wheel...
  97. ncbi PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 9:1050-6. 2006
    Dopamine neurotransmission is associated with high susceptibility to cocaine abuse...
  98. pmc Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats
    Agustin Zapata
    Integrative Neuroscience Section, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 30:15457-63. 2010
    ..Using a drug seeking/taking chained schedule of intravenous cocaine self-administration and reward devaluation methods in rats, the present studies examined whether drug seeking ..
  99. pmc Dose-dependent effects of multiple acute cocaine injections on maternal behavior and aggression in Sprague-Dawley rats
    J M Johns
    Department of Psychiatry, University of North Carolina, Chapel Hill, N C 27599 7096, USA
    Dev Neurosci 20:525-32. 1998
    ..5 mg/kg of cocaine hydrochloride HCl, or normal saline...
  100. ncbi Regulation of gene expression and cocaine reward by CREB and DeltaFosB
    Colleen A McClung
    The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 6:1208-15. 2003
    ..induced by short-term DeltaFosB and by CREB was strikingly similar, and both reduced the rewarding effects of cocaine, whereas prolonged DeltaFosB expression increased drug reward...
  101. ncbi Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 26:5881-7. 2006
    ..infusion of Zif268 antisense oligodeoxynucleotides into the basolateral amygdala shortly before reexposure to a cocaine-associated stimulus but not simply to the training context, severely impaired subsequently cue-maintained cocaine ..

Research Grants82

  1. COCAINE AND MATERNAL NEGLECT: INTERGENERATIONAL EFFECTS
    JOSEPHINE JOHNS; Fiscal Year: 2003
    ..Recently, lower levels of oxytocin and cocaine use during pregnancy have also been associated with general feelings of anger and hostility and difficulty with ..
  2. Sex Steroid Hormone Regulation of Drug Reinforcement
    Diane Lebesgue; Fiscal Year: 2012
    ..I will be assisted by my primary mentor Dr. Saleem Nicola to properly design and carry out cocaine self administration experiments. My co- mentor, Dr...
  3. Therapeutic Approaches for Extinction of Conditioned Drug Reward
    Gary B Kaplan; Fiscal Year: 2013
    ..use and abuse of prescription opiates is rising so that its prevalence is greater than that of heroin or cocaine abuse...
  4. Early social stress, novelty seeking, and impulsive behavior
    David M Lyons; Fiscal Year: 2013
    ..the effects of early social stress on subsequent resistance to extinction of a conditioned place preference for cocaine. Our preliminary evidence further suggests that early exposure to social stress induces long-lasting ..
  5. Histone Methylation: a role in excessive ethanol intake and self-administration
    Jennifer A Rinker; Fiscal Year: 2012
    ..A recent examination of the impact of cocaine on histone modifications demonstrated a role for [unreadable]FosB, a transcription factor induced by a number of ..
  6. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..mice, and a novel knock-in mouse with a point mutation that renders SERT insensitive to antidepressants and cocaine. We will also use electron microscopy (EM) to assess the number, size, and distribution of large dense core ..
  7. Neuronal mRNA PET Imaging
    Eric Wickstrom; Fiscal Year: 2010
    ..b>Cocaine, which binds to the dopamine receptor 2 (D2R), is the most widely abused drug...
  8. Dopamine Transporter Structure and Function
    Christopher K Surratt; Fiscal Year: 2010
    ..studies indicate that the DAT is the brain receptor chiefly responsible for the reward/reinforcing properties of cocaine and the amphetamines. The protein is further implicated in a host of CNS disorders...
  9. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia M Kuhn; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Women, who comprise about one third of cocaine addicts, start using cocaine earlier in life, are more sensitive than men to some cocaine effects and progress to dependence more rapidly...
  10. Developing Immunotherapeutics for Methamphetamine Abuse
    THOMAS RICHARD KOSTEN; Fiscal Year: 2010
    ..Vaccines against both nicotine and cocaine have been promising in both animal and human studies...
  11. Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African Americans
    ELIZABETH GROOMS NESMITH; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The overall goal of this project is to examine the effects of cocaine dependency on renal physiology in African Americans (AAs)...
  12. Preclinical studies of a heroin/morphine vaccine for opiate addiction
    Paul R Pentel; Fiscal Year: 2013
    ..Vaccines for nicotine and cocaine addictions are in clinical trials and preliminary data suggest efficacy...
  13. Multivalent Vaccine for Opiate Addiction
    Paul R Pentel; Fiscal Year: 2012
    ..have shown substantial preclinical and preliminary clinical evidence of efficacy for nicotine and cocaine addiction, and several heroin vaccines have shown promise in animal models...
  14. PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
    Navneet Kaur Dhillon; Fiscal Year: 2012
    ..the case that platelet-derived growth factor BB and its receptor play a prominent role in the HIV-protein Tat and cocaine mediated smooth muscle hyperplasia...
  15. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
    ..NSS include the transporters for dopamine, serotonin and norepinephrine-targets for amphetamine, cocaine, and antidepressant drugs-as well as the transporters for GABA and glycine, which are targeted for treatment of ..
  16. HIV/NeuroAIDS Patient Derived Induced Pluripotent Stem (iPS) Cells
    Rodney J Nash; Fiscal Year: 2012
    ..e. cocaine, opium, etc)...
  17. Sex and Stress Mechanisms of Vulnerability to Addiction
    Rajita Sinha; Fiscal Year: 2011
    ..We hypothesize that sex, stress and cocaine converge within the ventral tegmental area (VTA) having similar, and potentially additive, effects on dopamine (..
  18. 18F-beta-Endorphin Imaging: Translational Study of an Opioid Peptide Radiotracer
    BRIAN contact REED; Fiscal Year: 2010
    ..MOP-r are also prominently involved in the downstream effects of cocaine and alcohol addiction, and also modulate the hypothalamic-pituitary-adrenal (HPA)-stress axis, which is part of ..
  19. Prenatal Cocaine Exposure: Young Adult Follow Up
    Ruth Rose-Jacobs; Fiscal Year: 2013
    ..outcome following potential risk, provides an innovative framework for the longitudinal study of intrauterine cocaine exposure (IUCE) &intrauterine substance exposure (IUSE)...
  20. Growth and Cardiometabolic Risk Among In Utero Drug Exposed Children
    SARAH ELIZABETH MESSIAH; Fiscal Year: 2013
    ..Using data from the Miami Prenatal Cocaine Study (MFCS, Dr. Emmalee Bandstra, Principal Investigator), Dr...
  21. A novel and powerful C. elegans behavioral model of addiction
    Eric A Engleman; Fiscal Year: 2013
    ..demonstrate movement toward, and concentration- dependent self-exposure to, various psychoactive drugs including cocaine, methamphetamine, ethanol and caffeine...
  22. Persistent Attenuation of Cocaine-Reinforced Behavior
    KENNETH W GRASING; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Background Reinforcing effects of cocaine arise through release of dopamine (DA) in the nucleus accumbens by neurons that project from the ventral tegmental area (VTA)...
  23. Anabolic-androgenic steroids enhance motivation
    Ruth I Wood; Fiscal Year: 2013
    ..Indeed, the incidence of steroid use among high school seniors is comparable to that for cocaine or heroin...
  24. MOLECULAR NEUROBIOLOGY OF DRUG ADDICTION
    Eric J Nestler; Fiscal Year: 2013
    ..and multidisciplinary studies aimed at delineating the molecular and cellular mechanisms underlying opiate and cocaine addiction...
  25. Tacrine Effects on Cocaine Self-Administration and Pharmacokinetic Measures
    KENNETH W GRASING; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Reinforcing effects of cocaine are believed to arise through release of dopamine (DA) at the nucleus accumbens by neurons in the ventral tegmental area...
  26. Mechanisms and translation of lipid resuscitation
    Guy L Weinberg; Fiscal Year: 2013
    ..Finally, we seek to improve the translation of ILE to cocaine-related toxicity and longer-lasting overdoses such as calcium channel blocker toxicity...
  27. The Role of Kappa Opioid Receptor-induced Activation of Astrocytes in the Reinsta
    Charles Chavkin; Fiscal Year: 2009
    ..repeated forced swim, repeated social defeat, or foot shock), strongly potentiate the rewarding effects of cocaine in mice (as measured by an enhanced conditioned place preference to cocaine) and reinstate extinguished drug ..
  28. Prevalence of DSM-IV Disorders in an Multi-Center HIV+ Women's Cohort
    Judith A Cook; Fiscal Year: 2013
    ..The second aim is to conduct analyses addressing associations between 2 specific MH/SUDs -- depression and crack cocaine abuse/dependence - and immunological and virological components of disease progression and immune reconstitution, ..
  29. Inhibition of Carboxylesterase Metabolism by Ethanol
    Robert B Parker; Fiscal Year: 2011
    ..enzyme inhibitors, anticancer agents, statins, central nervous system stimulants, and drugs of abuse such as cocaine and heroin...
  30. Molecular mechanisms of neural plasticity in drug addiction
    LAURA NICOLE SMITH; Fiscal Year: 2010
    ..Recently, it has been shown that chronic cocaine exposure regulates spine density in the nucleus accumbens, the brain's reward center, via cyclic-adenosine ..
  31. Development of a Human Hydrolase to Treat Cocaine Abuse and Overdose: Rat Models
    WILLIAM STEPHEN BRIMIJOIN; Fiscal Year: 2011
    A novel concept for treatment of cocaine abuse envisages radically accelerated metabolism of cocaine as a means of reducing drug-seeking behavior...
  32. New Inactivators of GABA Aminotransferase for Addiction
    Richard B Silverman; Fiscal Year: 2013
    ..Increasing GABA levels blocks cocaine, nicotine, methamphetamine, alcohol, and heroin addiction in rats and cocaine addiction in humans without ..
  33. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2013
    ..is strikingly similar to human bipolar patients when in the manic state, including an increase in preference for cocaine. Interestingly, mice carrying a mutation in the Npas2 gene are similar in their responses when tested in ..
  34. Models for?functional evaluation of?CHRN polymorphisms
    Beverly H Koller; Fiscal Year: 2012
    ..The genetic contribution to addictions, including nicotine dependence, alcoholism and addiction to drugs such as cocaine, has been well established in studies of cohorts of twins...
  35. High Specificity HIV-1 Markers Predictive of Neuro-AIDS
    Brian Wigdahl; Fiscal Year: 2013
    ..advanced stage disease with end-organ involvement that may be exacerbated by specific co-morbidities such as cocaine or cannabinoid abuse The specific aims of this application are to continue to: (1) construct a HIV-1 (subtype B) ..
  36. Mechanisms of regulation of ethanol intake by lateral habenula
    Jiang Hong Ye; Fiscal Year: 2013
    ..a key role in nicotine addiction and withdrawal and in the regulation of morphine self-administration, as well as cocaine seeking behavior. However, the role of LHb in ethanol addiction has not been well explored...
  37. Regulation of Cocaine Reward and Reinforcement by MeCP2
    ANNE ELIZABETH WEST; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic cocaine abuse arises as a result of persistent cocaine-induced adaptations in the function of neurons within mesolimbocortical brain reward circuits...
  38. Effects on Caffeine on Adolescent Behavior and Physiology
    Jennifer L Temple; Fiscal Year: 2010
    ..In addition, caffeine usage increases sensitivity and potentiates addiction to cocaine, amphetamine, and nicotine...
  39. Designing an Integrated Nanoscale System for Ion Channel Structure-Function Study
    Ratneshwar Lal; Fiscal Year: 2013
    ..g., cocaine, nicotine) and pathological agents...
  40. The role of vagal afferent neurons in regulating feeding behavior
    GUILLAUME FH DE LARTIGUE; Fiscal Year: 2013
    ..To achieve this goal we propose to 1) determine the role of the neuropeptide transmitters cocaine and amphetamine regulated transcript (CART), and melanin concentrating hormone (MCH) released from VAN into the ..
  41. smFRET Investigation of Gating in a Neurotransmitter Transporter Homolog
    RACHEL ANN KOLSTER; Fiscal Year: 2013
    ..which are targeted by antidepressants, methylphenidate (Ritalin), and the widely abused psychostimulants cocaine and amphetamine...
  42. Progesterone-Induced Gene Expression Changes and Risk of Relapse to Cocaine Use
    Rajita Sinha; Fiscal Year: 2010
    ..of stress-induced craving, negative emotion, and physiology previously shown to predict risk for early relapse in cocaine addicted subjects...
  43. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..genes, KMO (kynurenin mono- oxygenase) and JNK-1 (c-jun N-terminal kinase), and of a novel transcript, CART (cocaine and amphetamine regulated transcript), that are markedly suppressed by E, with or without P...
  44. Extinction is mediated by the infralimbic cortex and protein kinase C epsilon
    Philip M Newton; Fiscal Year: 2010
    ..or entire medial prefrontal cortex of mice and then examine the extinction of a conditioned place preference for cocaine, morphine and ethanol...
  45. The Role of CLOCK in Ethanol-Related Behaviors
    Angela Renee Ozburn; Fiscal Year: 2012
    ..Mice bearing a dominant negative mutation in the CLOCK gene (CLOCK 19 mice) exhibit increased cocaine sensitivity and preference...
  46. Transport and Inhibition in a Biogenic Amine Transporter
    Satinder Singh; Fiscal Year: 2009
    ..diseases and because they are the target of a broad array of psychoactive agents such as antidepressants and cocaine. Despite such clinical importance, atomic-level detail into the mechanism of substrate translocation and ..
  47. Transport and Inhibition in a Biogenic Amine Transporter
    SATINDER KAUR SINGH; Fiscal Year: 2012
    ..diseases and because they are the target of a broad array of psychoactive agents such as antidepressants and cocaine. Despite such clinical importance, atomic-level detail into the mechanism of substrate translocation and ..
  48. Role of Dopamine Transporter: HIV-1 Tat Protein and Nicotine Sensitization
    Jun Zhu; Fiscal Year: 2010
    ..2008) and that intra-accumbal Tat alters the acute and sensitized response to cocaine (Harrod et al., 2008)...
  49. Histone Deacetylases: Regulators of Cocaine Reward and Targets for Therapeutics
    MARCELO ANDRES WOOD; Fiscal Year: 2012
    ..of Aim 1 of this grant proposal is to examine the role of histone deacetylase (HDAC) 3 in the acquisition of cocaine-induced conditioned place preference. HDAC3 is the most abundant class I HDAC expressed in brain...
  50. mGluR5 antagonists for methamphetamine addiction
    M Foster Olive; Fiscal Year: 2012
    ..For example, mice lacking mGluR5 receptors do not self-administer cocaine and are indifferent to its locomotor stimulant effects...
  51. Epigenetic regulation of HIV latency
    ERIC M VERDIN; Fiscal Year: 2013
    ..Since cocaine has emerged as a molecule that can modify epigenetic regulatory processes we also plan to examine its effect in ..
  52. Development of novel vaccines against drug abuse - Proof of concept study for vac
    CHENMING M ZHANG; Fiscal Year: 2012
    ..Among all drugs, tobacco, cocaine, and heroin are the most addictive ones...
  53. Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
    David W Self; Fiscal Year: 2012
    ..underlying sensitization in brain dopamine D2 receptors that would exacerbate drug craving and relapse in cocaine users, and investigates novel approaches to reverse D2 receptor sensitization as potential therapeutic ..
  54. GCs, CRF and Stressor-Induced Relapse
    John R Mantsch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): For many cocaine addicts, drug use is a stress-driven behavior...
  55. CNS circuitry and receptors mediating the effects of MDMA
    Daniel E Rusyniak; Fiscal Year: 2013
    ..involve pathophysiologic activation of sympathetic, somatic motor and neuroendocrine systems: serotonin syndrome;cocaine toxicity, neuroleptic malignant syndrome;dysautonomia from brain injury, and heat stroke...
  56. A Molecular Analysis of the Gateway Hypothesis in Mice
    Amir Levine; Fiscal Year: 2012
    ..g. cigarettes (nicotine), precedes the use of other drugs, such as cocaine. We propose to test the Gateway Hypothesis at the molecular level using a mouse model...
  57. Conformational Changes Underlying Intracellular Gating of the Leucine Transporter
    Kelli Kazmier; Fiscal Year: 2012
    ..hyperactivity disorder, and obsessive compulsive disorder as well as abuse and addiction to illicit drugs such as cocaine and amphetamine...
  58. Brain Development, Behavior and Cognition in Pre- and Postnatal Cocaine Exposure
    Tamara Duckworth Warner; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Knowledge about the effects of prenatal cocaine exposure (PCE) on brain development, behavior and cognition in humans lags far behind that of other drugs of abuse...
  59. Sex Differences in Vulnerability to Cocaine Addiction
    Therese Kosten; Fiscal Year: 2009
    ..We hypothesize that sex-dependent maternal care influences sex differences in stress responsivity and cocaine self-administration reflecting altered DNA methylation of specific genes (e.g...
  60. Miami Womens Interagency HIV Study WIHS
    Lisa R Metsch; Fiscal Year: 2013
    ..HIV-1 non-B subtype infections on the clinical course of HIV and response to therapy;and the interplay of crack cocaine use and associated co-occurring epidemics (mental health, poverty, unemployment and interpersonal violence with ..
  61. Competing roles of microRNAs and RNA-binding proteins in drug addiction
    NORA IRMA PERRONE-BIZZOZERO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Controlling motivation for cocaine is the goal of long-term treatment success of cocaine addiction, which may require reversal of drug-induced changes in gene expression...
  62. Dopamine Transporter Cell Surface Dynamics
    Haley E Melikian; Fiscal Year: 2013
    ..gene family and is the primary target for addictive and therapeutic psychostimulants, such as amphetamine, cocaine and methylphenidate (Ritalin) as well as for antidepressants, such as bupropion (Wellbutrin)...
  63. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina V Zhdanova; Fiscal Year: 2013
    ..The goal of the proposed project is to establish the role of the circadian system in the prenatal effects of cocaine exposure during a critical period of embryonic brain development in a diurnal vertebrate, zebrafish...
  64. Cocaine induced selective epigenetic and signaling pathways enhance HIV replicati
    Mudit Tyagi; Fiscal Year: 2013
    ..The drugs of abuse such as cocaine has also been implicated in HIV-1-associated pathogenesis e.g. HAD, HAND...
  65. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
    DESCRIPTION (Adapted from the Applicant's Abstract): Life threatening cardiac rhythm disturbances due to cocaine abuse, and treatment with specific antimicrobial agents such as macrolide antibiotics and pentamidine are well known...
  66. ENVIRONMENTAL AND PHARMACOLOGICAL CONTROL OF DRUG ABUSE
    Marilyn Carroll; Fiscal Year: 2000
    ..Protracted alterations in performance can be detected by sensitive behavioral tests after removal of cocaine and other drugs that do not result in an observable withdrawal syndrome...
  67. THE EFFECTS OF COCAINE ON FETAL OXYGENATION
    James Woods; Fiscal Year: 1993
    b>Cocaine produces increases in blood pressure and heart rate by interfering with the uptake and degradation of norepinephrine at adrenergic nerve terminals...
  68. COCAINE, ALCOHOL, AND COCAETHYLENE--CLINICAL EFFECTS
    Elinore McCance Katz; Fiscal Year: 2002
    Epidemiological studies have shown that at least 62% of cocaine abusers and possibly up to 90% in some populations are concomitant alcohol abusers...
  69. COCAINE AND PERINATAL CEREBRAL AND UMBILICAL VESSELS
    Michael Schreiber; Fiscal Year: 1992
    Prenatal cocaine abuse has reached epidemic proportions. IN certain high risk populations, over 33% of pregnant women expose their fetuses to cocaine. The effects of cocaine on the fetus are not fully understood...
  70. COCAINE, ALCOHOL, AND COCAETHYLENE--CLINICAL EFFECTS
    Elinore McCance Katz; Fiscal Year: 2000
    Epidemiological studies have shown that at least 62% of cocaine abusers and possibly up to 90% in some populations are concomitant alcohol abusers...
  71. EFFECTS OF COCAINE ON PLACENTAL GROWTH FACTORS
    Kathleen Shiverick; Fiscal Year: 1993
    b>Cocaine abuse during pregnancy has increased dramatically in association with intrauterine growth retardation, placental abruption and premature delivery...
  72. Medications for Comorbid Cocaine and Alcohol Dependence
    Rolley Johnson; Fiscal Year: 2002
    b>Cocaine abuse and dependence continues to be a major public health problem with up to 3 million people in need of treatment...
  73. Cocaine disruption of maternal motivation: preference for pups vs. cocaine
    MARIANA PEREIRA ARBOLEYA; Fiscal Year: 2010
    b>Cocaine abuse in women during the postpartum period is associated with dysfunctional maternal care, which can have severe lifelong consequences for the child...
  74. COCAINE & SEROTONIN NEUROCHEMISTRY
    DONALD KUHN; Fiscal Year: 1993
    b>Cocaine has rapidly become a major drug of abuse and the problems associated with its use have prompted such characterizations as "a national epidemic"...
  75. Human Laboratory Model of Cocaine Treatment: Behavioral Economic Analysis
    Mark K Greenwald; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Background: No anti-cocaine medication will be universally effective because non-medication factors such as environmental conditions (e.g. alternatives to drug use) and individual differences (e.g...
  76. GABA Agonists as Pharmacotherapies for Cocaine Abuse
    CRAIG RUSH; Fiscal Year: 2003
    b>Cocaine abuse continues to represent a significant public-health concern, and will likely remain a concern for the foreseeable future...
  77. SEROTONIN Treatment of Cocaine Dependence
    ERIC STRAIN; Fiscal Year: 2005
    ..renewal application to continue to study the efficacy of serotonergic medications in the outpatient treatment of cocaine dependence...
  78. COCAINE SELF-ADMINISTRATION/PHYSIOLOGICAL MEASURES
    Srihari Tella; Fiscal Year: 1999
    Adverse effects of cocaine, particularly on the cardiovascular system, are important clinical concerns...
  79. Cocaine Degrading Enzymes From Pest Insects Of Coca Plants
    Howard H Gu; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cocaine is a powerful psycho stimulant and one of the most addictive drugs of abuse...
  80. Role of astroglia in cocaine-induced neurotoxicity
    Helene Benveniste; Fiscal Year: 2009
    ..prototype optical diffusion fluorescence (ODF) probe to be used in vivo to study the role of astroglia cells in cocaine-induced effects on hemodynamics, metabolism and function in the brain...
  81. Adenovirus-based Anti-Cocaine Vaccine
    Ronald G Crystal; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cocaine addiction is a major problem for which there is currently no solution...
  82. RAPID DETOXIFICATION OF COCAINE BY BUTYRYLCHOLINESTERASE
    Oksana Lockridge; Fiscal Year: 2000
    DESCRIPTION (Applicant's Abstract): Cocaine has toxic effects on the brain and heart causing seizures, cerebral hemorrhage, a marked increased in heart rate, disturbance of heart rhythm, and hypertensive crisis...