capsaicin

Summary

Summary: Cytotoxic alkaloid from various species of Capsicum (pepper, paprika), of the Solanaceae.

Top Publications

  1. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
  2. ncbi Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis
    Cheol Hee Choi
    Research Center for Resistant Cells, College of Medicine, Chosun University, Seosuk dong, Dong Gu, Gwangju 501 759, Korea
    Mol Pharmacol 78:114-25. 2010
  3. ncbi The cloned capsaicin receptor integrates multiple pain-producing stimuli
    M Tominaga
    Department of Cellular and Molecular Pharmacology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
    Neuron 21:531-43. 1998
  4. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
  5. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
  6. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
  7. ncbi Capsaicin-induced apoptosis in human hepatoma HepG2 cells
    Shang Pang Huang
    Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    Anticancer Res 29:165-74. 2009
  8. pmc Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations
    Yuanyuan Cui
    Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, CA 95616, USA
    J Gen Physiol 139:273-83. 2012
  9. ncbi Direct activation of transient receptor potential V1 by nickel ions
    Matthias Luebbert
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Pflugers Arch 459:737-50. 2010
  10. ncbi Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase
    Jin Taek Hwang
    Department of Biochemistry and Molecular Biology, Medical Research Center for Bioreaction to Reactive Oxygen Species, Kyung Hee University College of Medicine, Seoul 130 701, Republic of Korea
    Biochem Biophys Res Commun 338:694-9. 2005

Detail Information

Publications368 found, 100 shown here

  1. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
    b>Capsaicin, the main pungent ingredient in 'hot' chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system...
  2. ncbi Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis
    Cheol Hee Choi
    Research Center for Resistant Cells, College of Medicine, Chosun University, Seosuk dong, Dong Gu, Gwangju 501 759, Korea
    Mol Pharmacol 78:114-25. 2010
    In our previous study, we showed that capsaicin induces autophagy in several cell lines...
  3. ncbi The cloned capsaicin receptor integrates multiple pain-producing stimuli
    M Tominaga
    Department of Cellular and Molecular Pharmacology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
    Neuron 21:531-43. 1998
    b>Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings...
  4. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
    ..It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8...
  5. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
    ..Here we show that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by Delta(9)-tetrahydrocannabinol (THC), the psychoactive ..
  6. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
    The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory neurons of the "pain" pathway...
  7. ncbi Capsaicin-induced apoptosis in human hepatoma HepG2 cells
    Shang Pang Huang
    Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    Anticancer Res 29:165-74. 2009
    b>Capsaicin, a pungent ingredient of red pepper, has been reported to possess antitumor activities. In this study, the effects of capsaicin on human HepG2 cells were investigated...
  8. pmc Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations
    Yuanyuan Cui
    Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, CA 95616, USA
    J Gen Physiol 139:273-83. 2012
    The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel...
  9. ncbi Direct activation of transient receptor potential V1 by nickel ions
    Matthias Luebbert
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Pflugers Arch 459:737-50. 2010
    ..we found that low millimolar doses of Ni2+ (NiSO4) are able to induce non-specific cation currents in a capsaicin-sensitive population of cultured mouse trigeminal ganglion neurons...
  10. ncbi Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase
    Jin Taek Hwang
    Department of Biochemistry and Molecular Biology, Medical Research Center for Bioreaction to Reactive Oxygen Species, Kyung Hee University College of Medicine, Seoul 130 701, Republic of Korea
    Biochem Biophys Res Commun 338:694-9. 2005
    ..We have investigated the effects of genistein, EGCG, and capsaicin on adipocyte differentiation in relation to AMPK activation in 3T3-L1 cells...
  11. pmc Unravelling the mystery of capsaicin: a tool to understand and treat pain
    Jessica O'Neill
    Neuroscience, Physiology and Pharmacology, University College London, London
    Pharmacol Rev 64:939-71. 2012
    A large number of pharmacological studies have used capsaicin as a tool to activate many physiological systems, with an emphasis on pain research but also including functions such as the cardiovascular system, the respiratory system, and ..
  12. ncbi A capsaicin-receptor homologue with a high threshold for noxious heat
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 398:436-41. 1999
    ..The cloned capsaicin receptor, also known as the vanilloid receptor subtype 1 (VR1), is a heat-gated ion channel that has been ..
  13. ncbi A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels
    Sebastian Brauchi
    Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and Universidad Austral de Chile, Valdivia, 905 9100, Chile
    J Neurosci 26:4835-40. 2006
    ..Thus, thermo-TRP channels contain an interchangeable specific region, different from the voltage sensor, which allows them to sense temperature stimuli...
  14. ncbi Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
    W Magerl
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Brain 124:1754-64. 2001
    ..Whereas sensitivities to heat and to the irritant substance capsaicin have recently been linked via the properties of the vanilloid receptor type 1 receptor ion channel, sensitivity ..
  15. ncbi Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet
    Ji Hye Kang
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, South Korea
    Obesity (Silver Spring) 18:780-7. 2010
    ..In this study, we investigated whether dietary capsaicin can reduce obesity-induced inflammation and metabolic disorders such as insulin resistance and hepatic steatosis...
  16. ncbi A new model of visceral pain and referred hyperalgesia in the mouse
    J M Laird
    Department of Physiology, University of Alcala, Alcala de Henares, E 28871, Madrid, Spain
    Pain 92:335-42. 2001
    ..For behavioural testing, they were placed on a raised grid and 50 microl of saline, mustard oil (0.25-2.5%) or capsaicin (0.03-0.3%) was administered by inserting a fine cannula into the colon via the anus...
  17. pmc Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
    V Vellani
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK
    J Physiol 534:813-25. 2001
    1. The effects of activation of protein kinase C (PKC) on membrane currents gated by capsaicin, protons, heat and anandamide were investigated in primary sensory neurones from neonatal rat dorsal root ganglia (DRG) and in HEK293 cells (..
  18. ncbi In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
    Ruifen Zhang
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Apoptosis 13:1465-78. 2008
    ..We investigated the mechanism of capsaicin, the major pungent ingredient of red-chili pepper, in inducing apoptosis in pancreatic cancer cells...
  19. pmc Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor
    Jennifer K Bonnington
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Physiol 551:433-46. 2003
    ..sensitisation of nociceptive sensory neurones to painful thermal stimuli owing to an action on the heat and capsaicin receptor TRPV1 (formerly known as VR1)...
  20. pmc Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway
    Kathleen C Brown
    Department of Pharmacology, Physiology and Toxicology, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia, United States of America
    PLoS ONE 5:e10243. 2010
    ..Therefore, novel therapeutic agents are urgently needed for this disease. Capsaicin, the active ingredient of chilli peppers, displays anti-proliferative activity in prostate and epidermoid cancer ..
  21. pmc Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells
    Chia Han Lin
    Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, 135 Nanhsiao St, Changhua, Taiwan
    BMC Complement Altern Med 13:46. 2013
    b>Capsaicin, a pungent phytochemical in a variety of red peppers of the genus Capsicum, has shown an anti-proliferative effect on various human cancer cell lines...
  22. ncbi The effects of Botulinum Toxin type A on capsaicin-evoked pain, flare, and secondary hyperalgesia in an experimental human model of trigeminal sensitization
    Parisa Gazerani
    Laboratory for Experimental Pain Research, Centre for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg, Denmark
    Pain 122:315-25. 2006
    ..injection of BoNT-A on an experimental human model of trigeminal sensitization induced by intradermal capsaicin injection to the forehead...
  23. pmc Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways
    M G Belvisi
    Respiratory Pharmacology Group, Airway Disease Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Br J Pharmacol 155:547-57. 2008
    ..Cannabinoids are known to inhibit airway sensory nerve function. However, there is still controversy surrounding which receptor is involved in eliciting these effects...
  24. ncbi Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain
    Margaret Z Chou
    Department of Ion Channels, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Biochemistry 43:2501-11. 2004
    The capsaicin receptor (TRPV1) is a nonselective cation channel that is activated in nociceptors by several painful stimuli, and hence TRPV1 antagonists could represent a novel class of analgesic compounds...
  25. ncbi Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo
    Hsu Feng Lu
    Department of Clinical Pathology, Cheng Hsin General Hospital, Taipei 112, Taiwan
    J Agric Food Chem 58:12999-3005. 2010
    b>Capsaicin was reported to inhibit cancer cell growth. The aim of this study was to evaluate the antitumor potential of capsaicin by studying antitumor activity in vitro as well as in vivo...
  26. ncbi Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress
    S W Ip
    Department of Nutrition, China Medical University, Taichung, Taiwan
    Hum Exp Toxicol 31:539-49. 2012
    b>Capsaicin, a pungent compound found in hot chili peppers, has been reported to have antitumor activities in many human cancer cell lines, but the induction of precise apoptosis signaling pathway in human nasopharyngeal carcinoma (NPC) ..
  27. pmc RSD931, a novel anti-tussive agent acting on airway sensory nerves
    J J Adcock
    Pneumolabs UK Ltd, NPIMR, Y Block, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Br J Pharmacol 138:407-16. 2003
    ..0 and 30.0 mg ml(-1) reduced the number of capsaicin-evoked coughs by 42.2 and 10.3% (P>0.05) (lidocaine) and by 25% (P>0.05) and 76.9% (P<0...
  28. pmc Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin
    Megan Grace
    Respiratory Pharmacology Group, Pharmacology and Toxicology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Thorax 67:891-900. 2012
    ..However, how this occurs is not understood...
  29. ncbi Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner
    Consuelo Amantini
    Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino MC, Italy
    Carcinogenesis 30:1320-9. 2009
    ..on human urothelial cancer (UC) cells and its involvement in the apoptosis induced by the selective agonist capsaicin (CPS)...
  30. pmc Sensory responses to injection and punctate application of capsaicin and histamine to the skin
    Parul Sikand
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Pain 152:2485-94. 2011
    A punctate, cutaneous application of capsaicin or histamine by means of a cowhage spicule elicits itch accompanied by pricking/stinging, burning, and typically, one or more areas of dysesthesia (alloknesis, hyperalgesia, hyperknesis)...
  31. pmc The effects of hedonically acceptable red pepper doses on thermogenesis and appetite
    Mary Jon Ludy
    Purdue University, West Lafayette, IN 47907, USA
    Physiol Behav 102:251-8. 2011
    ..This suggests that individuals may become desensitized to the effects of RP with long-term spicy food intake...
  32. ncbi Central representation of cold-evoked pain relief in capsaicin induced pain: an event-related fMRI study
    C Mohr
    Neuroimage Nord and Department of Neurology, University Hospitals Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Pain 139:416-30. 2008
    ..We aimed to identify central neural mechanisms of pain relief from capsaicin-elicited heat-hyperalgesia by administering cold stimuli...
  33. pmc TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch
    Sarah R Wilson
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA
    Nat Neurosci 14:595-602. 2011
    ..Similarly, TRPA1-deficient mice displayed little to no scratching in response to these pruritogens. Our findings indicate that TRPA1 is an essential component of the signaling pathways that promote histamine-independent itch...
  34. ncbi Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation
    Min Young Kim
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Anticancer Res 29:3733-40. 2009
    Although many studies have focused on anticarcinogenic properties of capsaicin and resveratrol, molecular mechanisms by which they selectively induce apoptosis are incompletely characterized...
  35. ncbi Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch
    Annika B Malmberg
    NeurogesX, Inc, 981F Industrial Road, San Carlos, CA 94070, USA
    Pain 111:360-7. 2004
    b>Capsaicin-containing plant extracts have been used as topical treatments for a variety of pain syndromes for many centuries. Current products containing capsaicin in low concentrations (usually 0.025-0...
  36. ncbi Long-term safety of NGX-4010, a high-concentration capsaicin patch, in patients with peripheral neuropathic pain
    David M Simpson
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Pain Symptom Manage 39:1053-64. 2010
    ..Current treatment options are often limited by poor tolerability...
  37. ncbi A multicenter, randomized, double-blind, controlled study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia
    Gordon A Irving
    Swedish Pain Center, Seattle, Washington, USA
    Pain Med 12:99-109. 2011
    To confirm the efficacy, tolerability, and safety of NGX-4010, an 8% capsaicin dermal patch (capsaicin 640 µg/cm(2) ), in patients with postherpetic neuralgia (PHN)...
  38. ncbi Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain
    Sunita Babbar
    NeurogesX, Inc, San Mateo, California 94404, USA
    Ther Drug Monit 31:502-10. 2009
    b>Capsaicin, a pungent compound in chili peppers, is a highly selective agonist for the transient receptor potential vanilloid 1 receptor expressed in nociceptive sensory nerves...
  39. ncbi Structure and function of TRPV1
    Makoto Tominaga
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    Pflugers Arch 451:143-50. 2005
    b>Capsaicin, the main ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system...
  40. ncbi Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells
    Chin Lin Hsu
    Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung 40227, Taiwan
    J Agric Food Chem 55:1730-6. 2007
    ..In the present study, the effects of capsaicin on the induction of apoptosis and inhibition of lipid accumulation in 3T3-L1 preadipocytes and adipocytes were ..
  41. pmc VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 68:543-56. 2010
    ..These mice showed deficits in pain behaviors, including mechanical pain, heat pain, capsaicin-evoked pain, inflammatory pain, and neuropathic pain...
  42. ncbi Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation
    C Amantini
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    J Neurochem 102:977-90. 2007
    ..expression of the transient receptor potential vanilloid type-1 (TRPV1) by glioma cells, and its involvement in capsaicin (CPS)-induced apoptosis...
  43. ncbi NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study
    Miroslav Backonja
    University of Wisconsin Madison, Madison, WI 53792, USA
    Lancet Neurol 7:1106-12. 2008
    ..NGX-4010, a high-concentration (8%) capsaicin dermal patch, was developed to treat patients with neuropathic pain...
  44. ncbi Visualizing cold spots: TRPM8-expressing sensory neurons and their projections
    Ajay Dhaka
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:566-75. 2008
    ..We show that TRPM8 expression functionally associates with cold sensitivity in cultured DRGs, and provide the first glimpses of the unique anatomical architecture of cold fibers in vivo...
  45. pmc A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating
    Benjamin R Myers
    Department of Physiology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94143 2140, USA
    Neuron 58:362-73. 2008
    ..an unbiased, high-throughput genetic screen in yeast that uncovered rare, constitutively active mutants of the capsaicin receptor, TRPV1...
  46. ncbi Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Germany
    J Neurophysiol 89:2441-8. 2003
    ..Histamine always provoked itching and rarely pain, capsaicin always pain but never itching. Prostaglandin E(2) (PGE(2)) led preferentially to moderate itching...
  47. pmc Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension
    Dachun Yang
    Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China
    Cell Metab 12:130-41. 2010
    ..Here we report that chronic TRPV1 activation by dietary capsaicin increases the phosphorylation of protein kinase A (PKA) and eNOS and thus production of nitric oxide (NO) in ..
  48. pmc Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human
    E Mezey
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Basic Neuroscience Program, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:3655-60. 2000
    ..In the central nervous system, neonatal capsaicin treatment depleted VR1 mRNA from the spinal nucleus of the trigeminal nerve, but not from other areas such as ..
  49. ncbi Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:8310-21. 2004
    ..In adult rat spinal slice preparations, activation of C-fiber primary afferents by a brief exposure of capsaicin produces an eightfold to 10-fold increase in ERK phosphorylation (pERK) in superficial dorsal horn neurons...
  50. ncbi The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
    Thomas Voets
    Laboratory of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 430:748-54. 2004
    ..The chemical agonists menthol (TRPM8) and capsaicin (TRPV1) function as gating modifiers, shifting activation curves towards physiological membrane potentials...
  51. ncbi Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice
    Punam Gauchan
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neurosci Lett 458:93-5. 2009
    ..These results suggest that cold allodynia induced by oxaliplatin is at least partly due to the increased expression of TRPM8 in the primary afferents...
  52. ncbi Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats
    Ming Kui Zhong
    Department of Physiology, Nanjing Medical University, Nanjing 210029, China
    Exp Physiol 93:746-53. 2008
    ..The CSAR was evaluated by the response of the RSNA to epicardial application of bradykinin or capsaicin. Bilateral microinjection of the anaesthetic, lignocaine, into the PVN abolished the CSAR without significant ..
  53. ncbi A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteers
    William R Kennedy
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Pain 11:579-87. 2010
    Desensitization of nociceptive sensory nerve endings is the basis for the therapeutic use of capsaicin in neuropathic pain syndromes...
  54. pmc Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization
    Armen N Akopian
    Department of Endodontics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Physiol 583:175-93. 2007
    ..Here we show that TRPA1 is desensitized by homologous (mustard oil; a TRPA1 agonist) and heterologous (capsaicin; a TRPV1 agonist) agonists via Ca2+-independent and Ca2+-dependent pathways, respectively, in sensory neurons...
  55. ncbi Roles of calcitonin gene-related peptide in facilitation of wound healing and angiogenesis
    Masaya Toda
    Department of Pharmacology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Biomed Pharmacother 62:352-9. 2008
    ..Wound healing process was significantly delayed in neuropeptide-depleted mice pretreated with capsaicin, compared with vehicle-treated mice...
  56. ncbi Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicin-induced nociceptive behaviors
    Tsukasa Sakurada
    First Department of Pharmacology, Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan
    Int Rev Neurobiol 85:237-48. 2009
    ..Recently, we have investigated the effects of BEO injected into the plantar surface of the hindpaw in the capsaicin test in mice...
  57. ncbi Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway
    Chu Chung Chou
    Department of Emergency Medicine, Changhua Christian Hospital, Changhua, Taiwan, R O C
    Oncol Rep 21:665-71. 2009
    b>Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a significant pungent ingredient in a variety of red peppers of the genus Capsicum, is a type of vanilloid...
  58. ncbi Effects of paraquat and capsaicin on the expression of genes related to inflammatory, immune responses and cell death in immortalized human HaCat keratinocytes
    N Paolillo
    IRCCS C Mondino Institute of Neurology Foundation, Pavia
    Int J Immunopathol Pharmacol 24:861-8. 2011
    ..were aimed to characterize in immortalized human HaCat keratinocytes the gene expression induced by paraquat and capsaicin, two agents known to induce cell death or to affect inflammatory and pain pathways, respectively...
  59. ncbi Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1
    Li Chieh Ching
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    Cardiovasc Res 91:492-501. 2011
    ....
  60. ncbi Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1
    Elsa Phillips
    Novartis Institutes of Biomedical Research, Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, United Kingdom
    J Biol Chem 279:17165-72. 2004
    ..response from >10,000 nm to 924 +/- 241 nm in [Ca(2+)](i) assays and increased capsazepine inhibition of the capsaicin response to levels seen for human TRPV1...
  61. ncbi Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species
    Keisuke Ito
    Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Cancer Res 64:1071-8. 2004
    b>Capsaicin (N-vanillyl-8-methyl-1-nonenamide) is a homovanillic acid derivative found in pungent fruits. Several investigators have reported the ability of capsaicin to inhibit events associated with the promotion of cancer...
  62. ncbi Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways
    J Yang
    Chengdu Medical College, Chengdu, People Republic of China
    Neoplasma 60:364-72. 2013
    ..b>Capsaicin, widely used as a food additive and as an analgesic agent, is a major pungent ingredient of red pepper...
  63. ncbi Effects of capsaicin on lipid catabolism in 3T3-L1 adipocytes
    Mak Soon Lee
    Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, 120 750, Korea
    Phytother Res 25:935-9. 2011
    b>Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a pungent ingredient of red peppers, and has been reported to reduce body weight gain and adiposity in rodents...
  64. ncbi Capsaicin inhibits growth of adult T-cell leukemia cells
    Jie Zhang
    Department of Pathology First Unit, Shimane Medical University, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    Leuk Res 27:275-83. 2003
    ..We examined the in vitro effects of capsaicin, the principal ingredients of red pepper, on three ATL cell lines...
  65. ncbi Antioxidant and antiapoptotic effects of capsaicin against carbon tetrachloride-induced hepatotoxicity in rats
    Memy H Hassan
    Department of Pharmacy, Faculty of Health Sciences, Taibah University, Saudi Arabia
    Toxicol Ind Health 28:428-38. 2012
    The aim of the study was to evaluate the potential hepatoprotective utility of capsaicin against carbon tetrachloride (CCl₄)-induced liver injury and to explore the possible mechanisms whereby this agent mediated its beneficial effects...
  66. ncbi Cofilin mediates tight-junction opening by redistributing actin and tight-junction proteins
    Yoko Nagumo
    Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8572, Japan
    Biochem Biophys Res Commun 377:921-5. 2008
    We previously found that capsaicin induces tight-junction (TJ) opening accompanied with cofilin dephosphorylation/activation in intestinal Caco-2 cells...
  67. ncbi Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin
    L Vyklicky
    Department of Cellular Neurophysiology, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 57:S59-68. 2008
    The rationale for the topical application of capsaicin and other vanilloids in the treatment of pain is that such compounds selectively excite and subsequently desensitize nociceptive neurons...
  68. ncbi Modulation of TRPV1-dependent contractility of normal and diabetic bladder smooth muscle by analgesic toxins from sea anemone Heteractis crispa
    Igor B Philyppov
    Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
    Life Sci 91:912-20. 2012
    TRPV1-expressing, capsaicin (CAP)-sensitive afferent fibers innervating bladder in addition to sensory function also exhibit "efferent" features consisting in TRPV1-dependent release of tachykinins (TAC) affecting detrusor smooth muscle (..
  69. pmc Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses
    Nicole Schöbel
    Department of Cell Physiology, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 7:e48005. 2012
    ..Ca(2+) responses induced by capsaicin, a prototypical stimulus of transient receptor potential vanilloid subfamily member-1 (TRPV1) were diminished in ..
  70. ncbi A reliable method for the preferential activation of C- or A-fibre heat nociceptors
    Simon McMullan
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Neurosci Methods 138:133-9. 2004
    ..Subsequently, the vanilloid capsaicin, which sensitises unmyelinated C-mechanoheat nociceptors, was shown to decrease the thresholds of reflex ..
  71. pmc Distinct modulations of human capsaicin receptor by protons and magnesium through different domains
    Shu Wang
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 285:11547-56. 2010
    The capsaicin receptor (TRPV1) is a nonselective cation channel that integrates multiple painful stimuli, including capsaicin, protons, and heat...
  72. ncbi Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
    J B Davis
    Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, UK
    Nature 405:183-7. 2000
    ..VR1 responds to noxious stimuli including capsaicin, the pungent component of chilli peppers, heat and extracellular acidification, and it is able to integrate ..
  73. ncbi Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity
    C Tohda
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Neurochem 76:1628-35. 2001
    b>Capsaicin receptors are expressed in primary sensory neurons and excited by heat and protons...
  74. ncbi Bee venom injection significantly reduces nociceptive behavior in the mouse formalin test via capsaicin-insensitive afferents
    Dae Hyun Roh
    Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, South Korea
    J Pain 7:500-12. 2006
    ..involved in producing the more prolonged antinociceptive effect observed in the mouse formalin test, and whether capsaicin-sensitive primary afferents are involved in these effects...
  75. pmc Trigeminal antihyperalgesic effect of intranasal carbon dioxide
    Alexander Z Tzabazis
    Department of Anesthesia, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 5117, USA
    Life Sci 87:36-41. 2010
    ..This study investigated the underlying mechanisms of this observation and its potential use to reverse trigeminal pain and hypersensitivity...
  76. ncbi Transient inhibition of the human motor cortex by capsaicin-induced pain. A study with transcranial magnetic stimulation
    S Farina
    Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, , Verona, Italy
    Neurosci Lett 314:97-101. 2001
    ..radialis (FCR), extensor carpi radialis (ECR) in 17 normal subjects, before and after painful application of capsaicin on the skin overlying the right FDI and FCR muscles...
  77. ncbi Anti-inflammatory effects of leptin and cholecystokinin on acetic acid-induced colitis in rats: role of capsaicin-sensitive vagal afferent fibers
    Ayhan Bozkurt
    Department of Physiology, School of Medicine, Marmara University, Haydarpasa, Istanbul, 34668, Turkey
    Regul Pept 116:109-18. 2003
    ..In a group of rats, vagal afferent fibers were denervated by topical application of capsaicin on the cervical vagi...
  78. pmc Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch
    P Anand
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, Area A, Ground Floor, Du Cane Road, London W12 ONN, UK
    Br J Anaesth 107:490-502. 2011
    Topical capsaicin formulations are used for pain management. Safety and modest efficacy of low-concentration capsaicin formulations, which require repeated daily self-administration, are supported by meta-analyses of numerous studies...
  79. ncbi The Pun1 gene for pungency in pepper encodes a putative acyltransferase
    Charles Stewart
    Department of Plant Biology, Cornell University, Ithaca, NY 14853, USA
    Plant J 42:675-88. 2005
    Pungency in Capsicum fruits is due to the accumulation of the alkaloid capsaicin and its analogs...
  80. ncbi Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers
    Mark Wallace
    Department of Anesthesiology, University of California, San Diego, USA
    Anesthesiology 107:785-96. 2007
    ..Using a human experimental pain model, the authors hypothesized that inhaled cannabis would reduce the pain and hyperalgesia induced by intradermal capsaicin.
  81. pmc Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling
    W Keith Jones
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, OH 45267 0575, USA
    Circulation 120:S1-9. 2009
    ..We previously described a remote cardioprotective effect of nonischemic surgical trauma (abdominal incision) called remote preconditioning of trauma (RPCT). In the present study, we elucidate mechanisms underlying this phenomenon...
  82. ncbi TRP channels and their implications in metabolic diseases
    Zhiming Zhu
    Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases and Chongqing Institute of Hypertension, Daping Hospital, Third Military Medical University, Chongqing, 400042, China
    Pflugers Arch 461:211-23. 2011
    ..This review provides new insight into the involvement of TRP channels in the pathogenesis of metabolic disorders and implicates these channels as potential therapeutic targets for the management of metabolic diseases...
  83. pmc Electroacupuncture suppresses capsaicin-induced secondary hyperalgesia through an endogenous spinal opioid mechanism
    Hee Young Kim
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Pain 145:332-40. 2009
    ..An animal model of capsaicin-induced pain has well-defined peripheral and central sensitization components, thus is useful for studying the ..
  84. ncbi VR-1 receptor blockade attenuates the pressor response to capsaicin but has no effect on the pressor response to contraction in cats
    Angela E Kindig
    Division of Cardiovascular Medicine, Department of Internal Medicine TB 172, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Am J Physiol Heart Circ Physiol 288:H1867-73. 2005
    Vanilloid type 1 (VR-1) receptors are stimulated by capsaicin and hydrogen ions, the latter being a by-product of muscular contraction...
  85. ncbi TRPV1 receptor blockade is ineffective in different in vivo models of migraine
    Oliver Summ
    University of California, USA
    Cephalalgia 31:172-80. 2011
    ..Due to a possible role of TRPV1 receptors in cortical spreading depression (CSD), an experimental phenomenon sharing many features with migraine aura, we also utilized a model of mechanically induced CSD...
  86. ncbi Capsaicin, transient receptor potential (TRP) protein subfamilies and the particular relationship between capsaicin receptors and small primary sensory neurons
    Hiroshi Nakagawa
    Center for Special Care in Dentistry School of Dentistry, University of Tokushima, Tokushima, Japan
    Anat Sci Int 81:135-55. 2006
    A number of subfamilies of the capsaicin receptor, collectively called TRP, have been reported since the discovery of vanilloid receptor 1 (VR1)...
  87. pmc 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism
    Darren Smart
    Neuroscience Research, Glaxo SmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Br J Pharmacol 136:452-8. 2002
    ..Lauroylethanolamide did not affect the dose - response curves to capsaicin. 4. Palmitoylethylamide was synthesized and found to be a mixed-type inhibitor (K(i(slope)) 4...
  88. ncbi Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    P M Zygmunt
    Department of Clinical Pharmacology, Institute of Laboratory Medicine, University of Lund, Sweden
    Nature 400:452-7. 1999
    ..Here we show that the vasodilator response to anandamide in isolated arteries is capsaicin-sensitive and accompanied by release of calcitonin-gene-related peptide (CGRP)...
  89. ncbi Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis
    Seah Fang Ang
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Crit Care Med 38:619-28. 2010
    ..However, whether endogenous hydrogen sulfide would induce transient receptor potential vanilloid type 1-mediated neurogenic inflammation in sepsis remains unknown...
  90. pmc Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells
    Kartick C Pramanik
    Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center, Amarillo, Texas, United States of America
    PLoS ONE 6:e20151. 2011
    We evaluated the mechanism of capsaicin-mediated ROS generation in pancreatic cancer cells...
  91. ncbi Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation
    M Y Jung
    College of Pharmacy, Duksung Women's University, 419 Ssangmun-Dong, Tobong-ku, 132-714, Seoul, South Korea
    Cancer Lett 165:139-45. 2001
    ..In the present study, we investigated the chemopreventive potential of capsaicin (8-methyl-N- vanillyl-6-nonenamide), the principal pungent ingredient found in hot red pepper, in SK-Hep-1 ..
  92. pmc TRPV1 activation is required for hypertonicity-stimulated inflammatory cytokine release in human corneal epithelial cells
    Zan Pan
    Department of Biological Sciences, College of Optometry, State University of New York, New York, New York 10065, USA
    Invest Ophthalmol Vis Sci 52:485-93. 2011
    ..To determine whether hypertonic stress promotes increases in inflammatory cytokine release through transient receptor potential vanilloid channel type 1 (TRPV1) signaling pathway activation in human corneal epithelial cells (HCECs)...
  93. pmc Phospholipase C mediated modulation of TRPV1 channels
    Tibor Rohacs
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Mol Neurobiol 37:153-63. 2008
    ..They are activated by heat, protons, and capsaicin and modulated by a plethora of other agents...
  94. ncbi Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) during capsaicin-induced pain: modulatory effects on motor cortex excitability
    Brigida Fierro
    Department of Clinical Neurosciences, University of Palermo, Palermo, Italy
    Exp Brain Res 203:31-8. 2010
    ..In the present study, we explored in healthy subjects the effect of capsaicin-induced pain and the modulatory influences of left DLPFC stimulation on motor corticospinal and intracortical ..
  95. ncbi Capsaicin dermal patch: in non-diabetic peripheral neuropathic pain
    Paul L McCormack
    Adis, Auckland, New Zealand
    Drugs 70:1831-42. 2010
    b>Capsaicin dermal patch is an adhesive patch containing a high concentration (8% w/w) of synthetic capsaicin...
  96. pmc The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew
    P L Andrews
    Department of Physiology, St George s Hospital Medical School, Cranmer Terrace, London
    Br J Pharmacol 130:1247-54. 2000
    1. In SUNCUS: murinus the ultrapotent capsaicin analogue resiniferatoxin (RTX) induced an emetic response in the dose range 1 - 1000 microg kg(-1), s.c. The latency was inversely related to dose and ranged from 41.2+/-4.4 min...
  97. ncbi Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization
    Jesper Dirks
    Laboratory of Pain Physiology, Department of Anesthesiology and Intensive Care Medicine, Herlev University Hospital, Herlev, Denmark
    Anesthesiology 97:102-7. 2002
    ..The aim of the present study was to link data from animal models and clinical trials for chronic pain by investigating the effect of gabapentin on acute nociception and experimentally induced cutaneous hyperalgesia in healthy volunteers...
  98. ncbi 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3
    Hong Zhen Hu
    Department of Physiology and Cell Biology, The Ohio State University, Columbus Ohio 43210, USA
    J Biol Chem 279:35741-8. 2004
    ..In addition, low levels of 2APB strongly potentiate the effect of capsaicin, protons, and heat on TRPV1 as well as that of heat on TRPV3 expressed in Xenopus oocytes...
  99. ncbi Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels
    Vincenzo Micale
    Department of Experimental and Clinical Pharmacology, University of Catania Medical School, Catania, Italy
    Neuropsychopharmacology 34:593-606. 2009
    ..Simultaneous 'indirect' activation of CB(1) receptors following FAAH inhibition, and antagonism at TRPV1 receptors might represent a new therapeutic strategy against anxiety...
  100. ncbi Functional role of C-terminal cytoplasmic tail of rat vanilloid receptor 1
    Viktorie Vlachova
    Institute of Physiology, Academy of Sciences, 142 20 Prague 4, Czech Republic
    J Neurosci 23:1340-50. 2003
    ..These changes were characterized by a decline of capsaicin-, pH-, and heat-sensitivity; progressive reduction of the activation thermal threshold (from 41.5 to 28...
  101. pmc Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier
    Simon Beggs
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Department of Physiology, University of Toronto, and University of Toronto Centre for the Study of Pain, Toronto, ON, Canada
    Mol Pain 6:74. 2010
    ..Whether discharge activity of sensory afferents entering the CNS may open the BBB or blood-spinal cord barrier (BSCB) remains an open question...

Research Grants64

  1. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..Primary sensory neurons are capsaicin-sensitive and express the capsaicin receptor [known as transient receptor potential vanilloid 1 (TRPV1)]...
  2. Chemoprevention of Pancreatic Cancer by Capsaicin
    Sanjay K Srivastava; Fiscal Year: 2013
    Principal Investigator: Srivastava, Sanjay K. CHEMOPREVENTION OF PANCREATIC CANCER BY CAPSAICIN Abstract Pancreatic cancer remains the fourth leading cause of cancer-related death in the United States with a median survival of less than ..
  3. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ..mechanisms, we have experimentally established an acute model of neurogenic inflammation by using an intradermal capsaicin (CAP) injection...
  4. POST-EXERCISE ION CHANNEL GENE EXPRESSION BIOMARKERS IN CFS
    Kathleen C Light; Fiscal Year: 2013
    ..channel receptors (including Acid Sensing Ion Channel-3 or ASIC3, ATP-sensing Purinergic 2X or P2X, and TRPV1 or capsaicin receptors) working together can detect increased metabolic by-products of work in muscle (ATP, lactate and pH ..
  5. Preclinical Development of a Novel and Effective Treatment for Cough
    Blake M Paterson; Fiscal Year: 2011
    ..Using in vivo methods, we will evaluate the potency, efficacy and duration of action of MMT against bradykinin, capsaicin and citric acid-induced cough, compared to DXM and codeine...
  6. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
    ..Over the last several years our research efforts have focused on the roles played by purinergic P2X receptors, capsaicin receptors (TRPV1) and acid sensing ion channels in evoking abnormal SNA responses to muscle contraction in HF...
  7. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012
    ..Other important examples include the use of natural irritants, such as capsaicin (from chili peppers) and menthol (from mint leaves) to identify ion channels that detect heat and cold, ..
  8. Central TRPV1 in Cardiovascular Regulation
    MICHAEL CHRISTIAN ANDRESEN; Fiscal Year: 2013
    ..This new form of glutamate transmission is only present in transmission from capsaicin sensitive solitary tract afferents...
  9. Effect of Articular Neurotoxin on Joint Pain and Neurochemical Signature
    Maren Lawson Mahowald; Fiscal Year: 2012
    ..We will compare the analgesic effect of neurotoxins such as intra-articular capsaicin, resiniferatoxin and iodo-resiniferatoxin to standard pain medications such as morphine using these measures of ..
  10. Mechanisms of Neuroprotection in the Nucleus Tractus Solitarius of Hibernators
    BARBARA ANN HORWITZ; Fiscal Year: 2010
    ..Over the last several years our research efforts have focused on the roles played by purinergic P2X receptors, capsaicin receptors (TRPV1) and acid sensing ion channels in evoking abnormal SNA responses to muscle contraction in HF...
  11. PROTEINASE-ACTIVATED RECEPTORS/PERIPHERAL NERVOUS SYSTEM
    Nigel W Bunnett; Fiscal Year: 2010
    ..by which sensitizing agents, such as PAR2, promote TRPV1 exocytosis, and by which desensitizing agents, such as capsaicin, promote TRPV1 endocytosis and degradation will be examined...
  12. Effects of Artemin on Nociceptors
    KATHRYN MARIE ALBERS; Fiscal Year: 2013
    ..ART-OE mice) or that are injected with Artn also exhibit behavioral sensitivity to heat, cold and chemical (capsaicin and mustard oil) stimuli...
  13. Role of the TRPV1 channel in myocardial salvage from ischemia-reperfusion injury
    ERIC RICHARD GROSS; Fiscal Year: 2012
    ..Research: Chili peppers produce their hot spicy taste by the compound capsaicin, which in turn also releases endorphins (a probable reason why we are fond of spicy food)...
  14. Interactions between Urological and Locomotor Systems during Treadmill Training i
    Patricia J Ward; Fiscal Year: 2012
    ..The role of C-fiber inputs will also be determined via capsaicin pre-treatment...
  15. TRPA1 Channels in Sensory Neurons as Targets for Environmental Irritants
    Sven Eric Jordt; Fiscal Year: 2012
    ..We found that TRPA1 is exclusively expressed in sensory fibers that are also sensitive to capsaicin, the plant-derived irritant that activates the capsaicin receptor, TRPV1...
  16. Lipid Regulation of Transient Receptor Potential Channels
    Tibor Rohacs; Fiscal Year: 2013
    ..TRPV1 channels are activated by heat, capsaicin, low pH and a plethora of other pain producing stimuli...
  17. Cross-sensitization in the pelvis and neurogenic bladder
    Anna P Malykhina; Fiscal Year: 2012
    ..Specific Aim 2 will focus on the role of capsaicin-sensitive C- and Adelta-fibers in the processing of nociceptive colonic afferent input to convergent and bladder ..
  18. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2012
    ..Selective ablation of sensory or sympathetic nerve fibers using capsaicin or guanethidine will allow us to determine whether these nerve fibers regulate bone remodeling/repair/healing ..
  19. Impact of Receptor Polymorphisms on Sensations from Common Oral Irritants
    JOHN EDWARD HAYES; Fiscal Year: 2013
    ..a laboratory study to quantify the impact of variation in specific genes on the sensations that arise from capsaicin (the compound responsible for the heat of 'hot'peppers), piperine (the compound responsible for the ..
  20. Receptor Selective Spinal Analgesia
    James Eisenach; Fiscal Year: 2013
    ..studies will test in new mothers whether the burning and hypersensitive response on the skin from application of capsaicin cream, a model of temporary pain sensitivity, are reduced compared to women without children...
  21. The Exercise Pressor Reflex in Cardiomyopathy
    Mary G Garry; Fiscal Year: 2013
    ..First, we have determined that the TRPv1 receptor (previously known as the capsaicin receptor) mediates the EPR in the rat...
  22. MOLECULAR MECHANISMS OF RECEPTOR AND CHANNEL FUNCTION
    David Julius; Fiscal Year: 2013
    ..This proposal is focused primarily on understanding the structure and biophysical properties of the capsaicin- and heat-activated receptor, TRPV1 - perhaps the best-characterized member of the mammalian TRP channel family...
  23. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2012
    ..whether females differ from males for increased release of SP following stimulation with either BK/PGE2 or with capsaicin. Specific Aim 2: Determine whether elevated circulating estradiol levels are associated with increased release ..
  24. Selective targeting of sodium channel blockers to pain-sensing neurons
    Bruce P Bean; Fiscal Year: 2012
    ..targeted selectively to nociceptors by co-applying a permanently charged derivative of lidocaine (QX- 314) with capsaicin, an agonist for TRPV1 channels...
  25. Surgical Modulation of Intestinal Nutrient Transport
    Ali Tavakkoli; Fiscal Year: 2013
    ..We hypothesize that blunting of ISS by selective vagal deafferentation with capsaicin (a naturally occurring pepper derivative) will rapidly improve glucose homeostasis, similar to RYGB, and lead to ..
  26. Role of the Supraspinal Opioidergic Circuit in Prefrontal TMS-Induced Analgesia
    JOSEPH JEFFREY TAYLOR; Fiscal Year: 2013
    ..will be used to assess pain perception via quantitative sensory testing on untreated skin and block testing on capsaicin-treated skin before and 0, 20 and 40 minutes after TMS treatment...
  27. Impact of Neprilysin on Islet Function
    Sakeneh Zraika; Fiscal Year: 2013
    ..The contribution of neural signaling to enhanced GSIS will be determined using selective hepatic vagotomies or capsaicin to block activation of pancreatic vagal efferents...
  28. Modulation of Colonic Response to Stress by Peripheral CRF2 Receptors
    MILLION MULUGETA; Fiscal Year: 2012
    ..Second, CRF1 activation enhances visceral pain response while CRF2 activation prevents capsaicin induced primary culture lumbosacral DRG neurons Ca2+ transients...
  29. Neural Mechanisms of Itch
    Earl E Carstens; Fiscal Year: 2013
    ..experimental chronic itch will lead to enhanced scratching elicited by pruritogens and also algogens such as capsaicin. We further hypothesize that experimental chronic itch sensitizes superficial dorsal horn neurons, manifested by ..
  30. Osteoarthritis Progression And Sensory Pathway Alterations
    Richard J Miller; Fiscal Year: 2013
    ..on intact DRG, L3/L4, and determine spontaneous activity as well as responses to stimuli including MCP-1, capsaicin, and ATP...
  31. Asynchronous Glutamate Release in Vagal Afferent to NTS Neurotransmission
    JAMES HENRY PETERS; Fiscal Year: 2013
    ..we found all afferents with activity-dependent asynchronous release were also activated by the TRPV1 agonist capsaicin. Further, antagonism of TRPV1 activity selectively reduced the asynchronous release profile with no effect on ..
  32. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..dependent on the neuropeptides neurotensin (NT) and substance P (SP), as it was absent in rodents treated with capsaicin to deplete sensory nerve fibers of their SP content and was also inhibited by the NT receptor antagonist SR48692...
  33. Regulation of Stomach Ghrelin
    GEORGE GREELEY; Fiscal Year: 2009
    ..secretion;that the stimulatory action of ghrelin on GH secretion is modulated by dietary intake;and that vagal capsaicin sensitive fibers participate in ghrelin secretion and ghrelin-activated GH secretion. Aim 2...
  34. Multiple Opioid Receptors and the Control of Pain
    Allan I Basbaum; Fiscal Year: 2013
    ..The MOR predominates in the peptidergic nociceptors, which express the capsaicin and heat responsive channel, TRPV1, and regulates heat pain. The present proposal builds upon these observations...
  35. Development of Anti-OLAM Aptamers as Novel Analgesics
    John G Bruno; Fiscal Year: 2012
    ..The proposal will develop a novel class of analgesics that work by blocking the endogenous capsaicin-like substances that are released during tissue injury.
  36. Peripheral and Central Sensitization in Pain
    JIN M CHUNG; Fiscal Year: 2012
    ..Project 2 is concerned with the critical role of ROS in central sensitization in the spinal cord using a capsaicin induced hyperalgesia model in mice (including mutant mice)...
  37. Serotonin Modulation of Trigeminal Nociceptors
    DAYNA RUTH LOYD; Fiscal Year: 2010
    ..the distribution of serotonin (5HT) receptors and overall integrated actions of 5HT on rat and human trigeminal capsaicin- sensitive nociceptors (craniofacial pain transmitting sensory neurons)...
  38. Direct assessment of distal small fiber neuropathy in models of neurotoxicity
    Elena Zotova; Fiscal Year: 2010
    ..in two distinct animal models of toxic neuropathy: ixabepilone (IXA), a new microtubule-stabilizing agent, and capsaicin (CAP), a local analgesic...
  39. Combinational anti-cancer effects of capsaicin and 3,3'-diindolylmethane in color
    Seong Ho Lee; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a natural product of the Capsicum species of red peppers, is known to induce apoptosis and suppress cell growth in various cancer models...
  40. Neural Mechanisms of Itch
    ROBERT H LA MOTTE; Fiscal Year: 2013
    ..by using chemically inert (heat inactivated) spicules soaked in an endogenous cysteine protease, histamine, or capsaicin. We propose to continue our combined, psychophysical and neurophysiological study of itch requiring the ..
  41. Mechanisms of TRPV1 Channel Regulation
    William N Zagotta; Fiscal Year: 2013
    ..are multimodal receptors that can be activated by heat, high [H+]o, voltage, arachidonic acid metabolites, capsaicin (the pungent extract of hot chili peppers), and the signaling lipid PI(4,5)P2 (PIP2)...
  42. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    ..nociceptors in certain chronic injury syndromes, relatively little is known about sympathetic modulation of capsaicin-sensitive fibers under control conditions...
  43. A Controlled Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
    DAVID CHARLES FOSTER; Fiscal Year: 2013
    ..treatment will reduce mechanical allodynia, reduce area and duration of hypersensitivity induced by intradermal capsaicin, reduce vaginal muscle pain to palpation, decrease the number and intensity of somatic tender points, and ..
  44. Transient Receptor Potential Vanilloid-1 Sensitization in Inflammation
    JARED MICHAEL SPRAGUE; Fiscal Year: 2013
    ..It is sensitive to heat, acid, and vanilloids, includig the 'hot'component of chili peppers, capsaicin. Several inflammatory compounds and pathways can affect its sensitivity to its known ligands...
  45. Capsaicin and Small cell Lung Cancer Therapy
    Piyali Dasgupta; Fiscal Year: 2012
    ..Our published data show that capsaicin (the spicy ingredient of chili peppers) displays anti-proliferative activity in a panel of human SCLC cell lines,..
  46. Mouse model of vestibulodynia using recurrent vulvovaginal Candidiasis
    MELISSA ANNE FARMER; Fiscal Year: 2010
    ..g., topical capsaicin) and to stimulate the development of new pharmacological interventions.
  47. Neurobiological Basis for Cold Transduction
    David D McKemy; Fiscal Year: 2010
    ..transient receptor potential (TRP) channel family, were identified by their sensitivity to compounds, such as capsaicin and menthol, which mimic distinct psychophysical sensations...
  48. REDOX PHARMACOLOGY OF T CHANNELS IN DRG NEURONS
    SLOBODAN TODOROVIC; Fiscal Year: 2009
    ..the endogenous amino acid L-cysteine increased T-channel-mediated excitability in a novel subpopulation of capsaicin-sensitive sensory neurons...
  49. The Role of the OLAM System in Burn Pain
    Dustin Green; Fiscal Year: 2013
    ..specific aims will test this innovative hypothesis: Specific Aim 1 Determine whether thermal injury activates capsaicin-sensitive nociceptors via CYP mediated release of OLAMs...
  50. Capsaicin-sensitive primary afferent fibers and neuropathic pain
    JENNIFER LYNN GIBBS; Fiscal Year: 2013
    ..Research Plan: Dr. Gibbs has propsed a series of studies to evaluate the role of capsaicin-sensitive primary afferent neurons in mediating NP by performing a cross-sectional study on subjects diagnosed ..
  51. TRPV1 regulation by B-arrestins
    ELAINE DARCEY POR; Fiscal Year: 2012
    ..culture model leads to increased receptor desensitization following repeat applications of the selective agonist capsaicin compared to cells transfected alone with TRPV1...
  52. Mechanisms of Sleep Disruption Hyperalgesia
    Michael T Smith; Fiscal Year: 2013
    ..disruption on spinal sensitization (secondary hyperalgesia) by evaluating laboratory pain responses in the heat-capsaicin pain model;2) examine the effects of sleep disruption on opioid analgesia and 3) determine the effects of sleep ..
  53. Structure and Function of TRPV Ion Channels
    Rachelle Gaudet; Fiscal Year: 2012
    ..Aim 3. To identify the structural determinants of capsaicin sensitivity in the TRPV1 channel: Ultimately, to understand how channel sensitivity is regulated, we also need ..
  54. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..hormone (CRH), treatment with the CRH-receptor antagonist Antalarmin or treatment neonatally with capsaicin to deplete sensory nerve fibers of their substance P (SP) content...
  55. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark A Schumacher; Fiscal Year: 2012
    ..TRPV1, also known as the capsaicin receptor, has been at the forefront of research focused on the development of new strategies to treat chronic ..
  56. Structure and Function of the Transient Receptor Potential Vanilloid-1 Channel
    LUCIANN L CUENCA; Fiscal Year: 2013
    ..TRPV1 is activated by noxious heat (>420C), protons, and vanilloid ligands such as capsaicin, the "spicy hot" component in chili peppers...
  57. Primary and Secondary Nociceptors in Persistent Pain
    H Richard Koerber; Fiscal Year: 2010
    ..In the third aim, we will use two trangenic mouse lines (one that has the capsaicin/heat channel TRPV1 knocked out, one that has the Mas-gene related G-protein coupled receptor D (Mrgdprd) knocked ..
  58. MECHANISMS OF SYNAPTIC TRANSMISSION IN THE RETINA
    Scott Nawy; Fiscal Year: 2013
    ..TRPV1 agonist such as capsaicin and anandamide appear to open the ON bipolar cell transduction channel as well...
  59. Sleep disturbance as a risk factor for developing chronic pain
    Clifford J Woolf; Fiscal Year: 2013
    ..affects CNS synaptic plasticity, we will also measure secondary hyperalgesia caused by intraplantar injection of capsaicin as a model of central sensitization, and we will then quantify the number of c-fos and p-ERK positive neurons in ..
  60. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 1993
    ..by which duodenal stimulation and CCK act will be studied using direct application of the sensory neurotoxin, capsaicin, to the vagus, coeliac/superior mesenteric ganglion or duodenum...
  61. Molecular Mechanism of pH Regulation of TRPV1 Activation
    Jie Zheng; Fiscal Year: 2013
    ..sensing function of TRPV1 by elucidating molecular mechanisms underlying its polymodal activation by heat, capsaicin and other stimuli...
  62. PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    Tony Yaksh; Fiscal Year: 1991
    ..apparent relative refractory period; Ca++ dependency and the local releasing and desensitizing effects of capsaicin. 2) "SP-LI release from the peripheral terminal occurs as a function of local thermal and chemical stimulation"...
  63. AFFERENT MECHANISMS UNDERLYING BLADDER PAIN
    WILLIAM DEGROAT; Fiscal Year: 2009
    ..ion channels including: tetrodotoxin-resistant Na+ channels, yanilloid receptors (VRl) which are sensitive to capsaicin, ATP-sensitive purinergic receptors, fast activation R+ channels and acid sensitive cation channels (ASIC), (3) ..
  64. BRAIN REGULATING GASTRIC ACID FUNCTION BY NEUROPEPTIDES
    YVETTE TACHE; Fiscal Year: 2000
    ..the vagal cholinergic gastric hyperemic response to central injection of TRH was shown to be mediated by capsaicin- calcitonin gene-related peptide (CGRP) and nitric oxide dependent mechanisms...