psilocybine

Summary

Summary: The major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being psilocin. (From Merck Index, 11th ed)

Top Publications

  1. ncbi Phylogenetic relationship of psychoactive fungi based on rRNA gene for a large subunit and their identification using the TaqMan assay (II)
    Takuro Maruyama
    National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Forensic Sci Int 163:51-8. 2006
  2. ncbi [Hallucinogenic fungi (psilocybe). Part II. Identification of Psilocybe semilanceata by PCR]
    Aldona Adamczyk
    Z Katedry Medycyny Sadowej i Zakładu Technik Molekularnych Akademii Medycznej we Wrocławiu K ierownik dr hab T Dobosz
    Arch Med Sadowej Kryminol 57:285-8. 2007
  3. pmc Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
    Roland R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 218:649-65. 2011
  4. ncbi Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies
    Erich Studerus
    University Hospital of Psychiatry Zurich, Neuropsychopharmacology and Brain Imaging and Heffter Research Center, Zurich, Switzerland
    J Psychopharmacol 25:1434-52. 2011
  5. ncbi Harm potential of magic mushroom use: a review
    Jan van Amsterdam
    Laboratory for Health Protection Research, RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Regul Toxicol Pharmacol 59:423-9. 2011
  6. ncbi Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance
    R R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510, Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 187:268-83; discussion 284-92. 2006
  7. ncbi Mismatch negativity predicts psychotic experiences induced by NMDA receptor antagonist in healthy volunteers
    Daniel Umbricht
    Psychiatric University Hospital Zurich, Department of Psychiatric Research, Zurich, Switzerland
    Biol Psychiatry 51:400-6. 2002
  8. pmc Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later
    Rr Griffiths
    Department of Psychiatry and Behavioral Sciences and Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    J Psychopharmacol 22:621-32. 2008
  9. ncbi Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study
    Felix Hasler
    Heffter Research Center, Psychiatric University Hospital Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
    Psychopharmacology (Berl) 172:145-56. 2004
  10. ncbi Common drugs of abuse--Part II
    Mary Linda Stotter Cuddy
    J Pract Nurs 54:5-8, 25-31; quiz 17-9. 2004

Research Grants

  1. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 2002
  2. BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
    JERROLD WINTER; Fiscal Year: 2005
  3. Tryptophan Depletion: A Phenotypic Marker for Depression
    Francisco Moreno; Fiscal Year: 2007
  4. Indole Analogs as Novel Treatments for OCD
    Howard Sard; Fiscal Year: 2008
  5. REVAMP Follow-Up Study
    Francisco Moreno; Fiscal Year: 2008
  6. 12-Step Facilitation for the Dually Diagnosed
    Michael Bogenschutz; Fiscal Year: 2009
  7. Behavioral and Pharmacological Analysis of Drugs of Abuse
    JERROLD WINTER; Fiscal Year: 2008
  8. Effects of self-administered MDMA on brain and behavior in rhesus monkeys
    William Fantegrossi; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications106 found, 100 shown here

  1. ncbi Phylogenetic relationship of psychoactive fungi based on rRNA gene for a large subunit and their identification using the TaqMan assay (II)
    Takuro Maruyama
    National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Forensic Sci Int 163:51-8. 2006
    ..In this paper, we describe the new system capable of distinguishing MMs from non-psilocybin Psilocybe species, its application data and the phylogeny of MM species...
  2. ncbi [Hallucinogenic fungi (psilocybe). Part II. Identification of Psilocybe semilanceata by PCR]
    Aldona Adamczyk
    Z Katedry Medycyny Sadowej i Zakładu Technik Molekularnych Akademii Medycznej we Wrocławiu K ierownik dr hab T Dobosz
    Arch Med Sadowej Kryminol 57:285-8. 2007
    ..Detection of the specific DNA sequence for P semilanceata brought good results; the test may be commonly employed in forensic practice in the future...
  3. pmc Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
    Roland R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 218:649-65. 2011
    ..This dose-effect study extends previous observations showing that psilocybin can occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior...
  4. ncbi Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies
    Erich Studerus
    University Hospital of Psychiatry Zurich, Neuropsychopharmacology and Brain Imaging and Heffter Research Center, Zurich, Switzerland
    J Psychopharmacol 25:1434-52. 2011
    ....
  5. ncbi Harm potential of magic mushroom use: a review
    Jan van Amsterdam
    Laboratory for Health Protection Research, RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Regul Toxicol Pharmacol 59:423-9. 2011
    ..The low prevalent but unpredictable provocation of panic attacks and flash-backs remain, however, a point of concern...
  6. ncbi Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance
    R R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510, Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 187:268-83; discussion 284-92. 2006
    ..Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects...
  7. ncbi Mismatch negativity predicts psychotic experiences induced by NMDA receptor antagonist in healthy volunteers
    Daniel Umbricht
    Psychiatric University Hospital Zurich, Department of Psychiatric Research, Zurich, Switzerland
    Biol Psychiatry 51:400-6. 2002
    ....
  8. pmc Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later
    Rr Griffiths
    Department of Psychiatry and Behavioral Sciences and Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    J Psychopharmacol 22:621-32. 2008
    ....
  9. ncbi Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study
    Felix Hasler
    Heffter Research Center, Psychiatric University Hospital Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
    Psychopharmacology (Berl) 172:145-56. 2004
    ..Pharmacological challenge with the 5-HT(2A) agonist psilocybin (PY) is useful in studying the neurobiological basis of cognition and consciousness...
  10. ncbi Common drugs of abuse--Part II
    Mary Linda Stotter Cuddy
    J Pract Nurs 54:5-8, 25-31; quiz 17-9. 2004
    ..Drug abuse affects a significant number of individuals of all ages. Health care practitioners must be knowledgeable about both the physiological effects of such drugs and the impact of drug-seeking behavior on their patients...
  11. ncbi Effects of the hallucinogen psilocybin on covert orienting of visual attention in humans
    E Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Technology RWTH Aachen, Germany
    Neuropsychobiology 45:205-12. 2002
    ..NMDA antagonists) and different dose regimens are needed in order to further explore the suggested relationship between visuospatial attentional dysfunction and acute psychotic conditions...
  12. ncbi Modulating the rate and rhythmicity of perceptual rivalry alternations with the mixed 5-HT2A and 5-HT1A agonist psilocybin
    Olivia L Carter
    Vision Touch and Hearing Research Center, School of Biomedical Science, University of Queensland, Australia
    Neuropsychopharmacology 30:1154-62. 2005
    ..This study suggests the involvement of serotonergic pathways in binocular rivalry and supports the previously proposed role of a brainstem oscillator in perceptual rivalry alternations and symptoms of psychosis...
  13. ncbi Effects of psilocybin on time perception and temporal control of behaviour in humans
    Marc Wittmann
    Generation Research Programme, Human Science Centre, Ludwig Maximilian University Munich, Bad Tölz, Germany, and Heffter Research Centre, University Hospital of Psychiatry, Zurich, Switzerland
    J Psychopharmacol 21:50-64. 2007
    ..We speculate that psilocybin's selective disruption of longer intervals is likely to be a product of interactions with cognitive dimensions of temporal processing -presumably via 5-HT2A receptor stimulation...
  14. ncbi [Hallucinogen-induced psychological disorders]
    L Hermle
    Klinik für Psychiatrie und Psychotherapie Christophsbad, Goppingen
    Fortschr Neurol Psychiatr 76:334-42. 2008
    ..In addition to LSD and psilocybin hallucinogens of biologic origin are increasingly used by adolescents and young adults...
  15. ncbi Iconography in Bradshaw rock art: breaking the circularity
    Jack Pettigrew
    School of Biomedical Sciences and Queensland Brain Institute, University of Queensland, Brisbane, Australia
    Clin Exp Optom 94:403-17. 2011
    ....
  16. pmc Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens
    Adam L Halberstadt
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States
    Neuropharmacology 61:364-81. 2011
    ..This article reviews the evidence demonstrating that the effects of indoleamine hallucinogens in a variety of animal behavioral paradigms are mediated by both 5-HT(2) and non-5-HT(2) receptors...
  17. pmc Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice
    Adam L Halberstadt
    Department of Psychiatry, University of California, La Jolla, CA 92093 0804, USA
    J Psychopharmacol 25:1548-61. 2011
    ..The fact that 1-methylpsilocin displays greater pharmacological selectivity than psilocin indicates that 1-methylpsilocin represents a potentially useful alternative to psilocybin for development as a potential therapeutic agent...
  18. pmc Psychedelics and mental health: a population study
    Teri S Krebs
    Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    PLoS ONE 8:e63972. 2013
    ..Psychedelics have been used in the Americas for thousands of years. Over 30 million people currently living in the US have used LSD, psilocybin, or mescaline...
  19. ncbi A proposal to evaluate mechanistic efficacy of hallucinogens in addiction treatment
    Brittany Vasae Burdick
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Drug Alcohol Abuse 39:291-7. 2013
    ..The outcomes of such a study would reveal important differences in therapeutic potential by discriminating hallucinogen-dependent effects from those psychological effects resulting from altered states...
  20. ncbi Dr. Leary's Concord Prison Experiment: a 34-year follow-up study
    R Doblin
    Kennedy School of Government, Harvard University, USA
    J Psychoactive Drugs 30:419-26. 1998
    ..Whether a new program of psilocybin-assisted group psychotherapy and post-release programs would significantly reduce recidivism rates is an empirical question that deserves to be addressed within the context of a new experiment...
  21. ncbi Neuroimaging: a scanner, colourfully
    Jonathan P Roiser
    UCL Institute of Cognitive Neuroscience, London, UK
    Curr Biol 22:R231-3. 2012
    ..Psilocybin increased sensory cortex responses during emotional recollection, but decreased resting-state blood flow in prefrontal cortex, with potential implications for treating depression...
  22. pmc Psychometric evaluation of the altered states of consciousness rating scale (OAV)
    Erich Studerus
    Neuropsychopharmacology and Brain Imaging and Heffter Research Center, University Hospital of Psychiatry Zurich, Zurich, Switzerland
    PLoS ONE 5:e12412. 2010
    ....
  23. ncbi Psychopathological, neuroendocrine and autonomic effects of 3,4-methylenedioxyethylamphetamine (MDE), psilocybin and d-methamphetamine in healthy volunteers. Results of an experimental double-blind placebo-controlled study
    E Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Technology, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Psychopharmacology (Berl) 142:41-50. 1999
    ....
  24. ncbi Synthesis of a psilocin hapten and a protein-hapten conjugate
    Christian Albers
    Institute of Pharmaceutical and Medicinal Chemistry, University of Munster, Germany
    J Pharm Pharmacol 54:1265-70. 2002
    ..The protein-hapten conjugate was characterized by matrix-assisted laser desorption ionization mass spectrometry. The mass spectrometry data indicated an average incorporation ratio of 4-5 molecules of psilocin hapten per molecule of BSA...
  25. ncbi [Concentration of selected microelements in blood serum of rats exposed to the action of psilocin and phenylethylamine]
    Sławomir Majdanik
    Zakład Medycyny Sadowej Pomorskiej Akademii Medycznej w Szczecinie, Al Powstancow Wlkp 72, 70 111 Szczecin
    Ann Acad Med Stetin 53:153-8. 2007
    ..Basing on the obtained results, it can be stated that subchronic intoxication with natural hallucinogens may disturb magnesium balance without significantly effecting other microelements...
  26. ncbi Between prohibitions: patterns and meanings of magic mushroom use in the UK
    Sarah C E Riley
    Department of Psychology, University of Bath, Bath, UK
    Subst Use Misuse 43:55-71. 2008
    ..Four focus groups aided the interpretation of the data. Future research is recommended into negative experiences. Implications for policy and harm minimisation literature are discussed...
  27. pmc Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers
    Matthew W Johnson
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 123:132-40. 2012
    ..Although psilocybin is structurally related to migraine medications, and case studies suggest that psilocybin may be efficacious in treatment of cluster headache, little is known about the relationship between psilocybin and headache...
  28. ncbi The effect of Psilocybe cubensis extract on hippocampal neurons in vitro
    M G Moldavan
    A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev
    Fiziol Zh 47:15-23. 2001
    ..It is concluded, that application of PCB-containing extract in most cases reduced spike activity in hippocampal CA1 pyramidal neurons and suppressed glutamate transmission...
  29. pmc Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases
    Nenad Manevski
    Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    Drug Metab Dispos 38:386-95. 2010
    ....
  30. ncbi [Suicide under the influence of "magic mushrooms"]
    Katja Müller
    Institut für Rechtsmedizin der Universität Hamburg
    Arch Kriminol 231:193-8. 2013
    ..Our case report demonstrates the suicide of a man by self-inflicted cut and stab injuries. A causal connection between suicidal behaviour and previous ingestion of psychoactive mushrooms is discussed...
  31. ncbi Broadband cortical desynchronization underlies the human psychedelic state
    Suresh D Muthukumaraswamy
    Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF119BJ, United Kingdom, Imperial College London, Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, London W12 ONN, United Kingdom, Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom, Sir Peter Mansfield Magnetic Resonance Centre, Nottingham University, Nottingham NG7 2RD, United Kingdom, Academic Unit of Psychiatry, University of Bristol, Bristol BS8 2BN, United Kingdom, The Beckley Foundation, Beckley Park, Oxford OX3 9SY, United Kingdom, and Virginia Tech Carilion Research Institute, and Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Roanoke, Virginia 24016
    J Neurosci 33:15171-83. 2013
    ..These findings suggest that the subjective effects of psychedelics result from a desynchronization of ongoing oscillatory rhythms in the cortex, likely triggered by 5-HT2A receptor-mediated excitation of deep pyramidal cells...
  32. ncbi Peak experiences of psilocybin users and non-users
    Christina Cummins
    Social and Behavioral Sciences, Richard Stockton College of New Jersey, 101 Vera King Farris Drive, Galloway, NJ 08205 9941, USA
    J Psychoactive Drugs 45:189-94. 2013
    ..Future research is necessary to identify factors that influence the peak experiences of psilocybin users in naturalistic settings and contribute to the different characteristics of peak experiences of psilocybin users and non-users...
  33. ncbi Enzyme-assisted synthesis of the glucuronide conjugate of psilocin, an hallucinogenic component of magic mushrooms
    Takuji Shoda
    National Institute of Health Sciences, Kamiyoga, Setagaya Ku, Tokyo, Japan
    Drug Test Anal 3:594-6. 2011
    ..6 mg). The compound structure was characterized by MS and NMR. The milligram amounts of PCG produced by this method will allow the direct identification and quantification of PCG in the urine of MM users...
  34. pmc Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness
    Katherine A MacLean
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Psychopharmacol 25:1453-61. 2011
    ..The findings suggest a specific role for psilocybin and mystical-type experiences in adult personality change...
  35. ncbi Repression of death consciousness and the psychedelic trip
    Varsha Dutta
    Department of Clinical Neuroscience and ACRO, Dr Balabhai Nanavati Hospital, S V Road, Vile Parle, Mumbai, India
    J Cancer Res Ther 8:336-42. 2012
    ..How much of what was threaded in the ritual and spiritual mores can be extricated and be interpreted in our own mechanized language of medicine is the question that nudges many...
  36. ncbi Illicit use of LSD or psilocybin, but not MDMA or nonpsychedelic drugs, is associated with mystical experiences in a dose-dependent manner
    Michael Lyvers
    Department of Psychology, Bond University, Gold Coast Queensland 4229, Australia
    J Psychoactive Drugs 44:410-7. 2012
    ..Results suggest that even in today's context of "recreational" drug use, psychedelics such as LSD and psilocybin, when taken at higher doses, continue to induce mystical experiences in many users...
  37. ncbi Activation of serotonin 2A receptors underlies the psilocybin-induced effects on α oscillations, N170 visual-evoked potentials, and visual hallucinations
    Michael Kometer
    Neuropsychopharmacology and Brain Imaging, Clinic of Affective Disorders and General Psychiatry, University Hospital of Psychiatry, University of Zurich, Zurich 8008, Switzerland
    J Neurosci 33:10544-51. 2013
    ..This change in N170 potentials may be important not only for psilocybin-induced states but also for understanding acute hallucinatory states seen in psychiatric disorders, such as schizophrenia and Parkinson's disease...
  38. ncbi The NMDA antagonist ketamine and the 5-HT agonist psilocybin produce dissociable effects on structural encoding of emotional face expressions
    Andre Schmidt
    Neuropsychopharmacology and Brain Imaging, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland
    Psychopharmacology (Berl) 225:227-39. 2013
    ..However, as yet, no study has systematically compared their contribution to emotional biases...
  39. ncbi Serotonergic hallucinogens and emerging targets for addiction pharmacotherapies
    Stephen Ross
    Division of Alcoholism and Drug Abuse, Bellevue Hospital Center and the New York University School of Medicine, New York, NY 10016, USA
    Psychiatr Clin North Am 35:357-74. 2012
    ..They truly represent a potential paradigmatic shift within the field of psychiatry, too interesting to not explore further...
  40. pmc Psilocybin-induced deficits in automatic and controlled inhibition are attenuated by ketanserin in healthy human volunteers
    Boris B Quednow
    Neuropsychopharmacology and Brain Imaging, Clinic of Affective Disorders and General Psychiatry, University Hospital of Psychiatry, Heffter Research Center, Zurich, Switzerland
    Neuropsychopharmacology 37:630-40. 2012
    ..Sensorimotor gating and attentional control deficits of schizophrenia patients might be due to changes within the 5-HT(2A)R system...
  41. ncbi Psilocybin biases facial recognition, goal-directed behavior, and mood state toward positive relative to negative emotions through different serotonergic subreceptors
    Michael Kometer
    Neuropsychopharmacology and Brain Imaging, and Heffter Research Center, Clinic of Affective Disorders and General Psychiatry, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland
    Biol Psychiatry 72:898-906. 2012
    ..However, the effect of psilocybin on emotional processing biases and the specific contribution of 5-HT2A receptors across different emotional domains is unknown...
  42. pmc Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
    Robin L Carhart-Harris
    Neuropsychopharmacology Unit, University of Bristol, Bristol BS8 2BN, United Kingdom
    Proc Natl Acad Sci U S A 109:2138-43. 2012
    ..These results strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition...
  43. pmc High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens
    CHAD J REISSIG
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 223:1-15. 2012
    ..Although reports of dextromethorphan (DXM) abuse have increased recently, few studies have examined the effects of high doses of DXM...
  44. ncbi Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin
    R L Carhart-Harris
    Imperial College London, Neuropsychopharmacology Unit, 5th Floor, Burlington Danes Building, 160 Du Cane Road, London W12 0NN, UK
    Br J Psychiatry 200:238-44. 2012
    ..Psilocybin is a classic psychedelic drug that has a history of use in psychotherapy. One of the rationales for its use was that it aids emotional insight by lowering psychological defences...
  45. ncbi [Automutilation after consumption of hallucinogenic mushrooms]
    M E Attema-de Jonge
    Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091 AC Amsterdam
    Ned Tijdschr Geneeskd 151:2869-72. 2007
    ..The diagnosis ofpsilocybin intoxication is hampered by the lack of routinely available, rapid and sensitive, analytical methods for the quantification ofpsilocybin and its active metabolite psilocin...
  46. ncbi Effects of varied doses of psilocybin on time interval reproduction in human subjects
    Jiri Wackermann
    Department of Empirical and Analytical Psychophysics, Institute for Frontier Areas of Psychology and Mental Health, Wilhelmstrasse 3a, D 79098 Freiburg i Br, Germany
    Neurosci Lett 435:51-5. 2008
    ..These findings are tentatively linked to qualitative alterations of subjective time in altered states of consciousness...
  47. ncbi The structure of human serotonin 2c G-protein-coupled receptor bound to agonists and antagonists
    Jenelle K Bray
    Materials and Process Simulation Center, California Institute of Technology, Pasadena, CA 91125, United States
    J Mol Graph Model 27:66-81. 2008
    ..We also compare a preliminary prediction for 5-HT(2B) with our prediction for 5-HT(2C) and find a difference in TM5 that contributes to different serotonin binding modes in 5-HT(2B) and 5-HT(2C)...
  48. pmc Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 88:358-65. 2008
    ....
  49. ncbi Psilocybin links binocular rivalry switch rate to attention and subjective arousal levels in humans
    Olivia L Carter
    Vision Touch and Hearing Research Center, School of Biomedical Science, University of Queensland, Brisbane, Australia
    Psychopharmacology (Berl) 195:415-24. 2007
    ..Previous studies have suggested that a slow rate of perceptual switching may be associated with clinical and drug-induced psychosis...
  50. ncbi Unrecognized magic mushroom abuse in a 28-year-old man
    Ryan L McClintock
    Department of Emergency Medicine, St Luke s Hospital, Bethlehem, PA 18015, USA
    Am J Emerg Med 26:972.e3-4. 2008
    ..We feel that had this been considered initially, the correct diagnosis would have led to a better utilization of resources, and we want to remind emergency physicians of the possibility of mushroom abuse in any similar clinical setting...
  51. ncbi The 5-HT2A/1A agonist psilocybin disrupts modal object completion associated with visual hallucinations
    Michael Kometer
    University Hospital of Psychiatry, Neuropsychopharmacology and Brain Imaging and Heffter Research Center, Lenggstrasse 31, Zurich, Switzerland
    Biol Psychiatry 69:399-406. 2011
    ....
  52. ncbi Lysergic acid diethylamide (LSD) administration selectively downregulates serotonin2 receptors in rat brain
    N S Buckholtz
    National Institute of Mental Health, Laboratory of Clinical Science, Bethesda, MD 20892
    Neuropsychopharmacology 3:137-48. 1990
    ....
  53. ncbi Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer
    Charles S Grob
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Arch Gen Psychiatry 68:71-8. 2011
    ..This investigation reexamines a potentially promising clinical application of hallucinogens in the treatment of anxiety reactive to advanced-stage cancer...
  54. ncbi Turn on, tune in, but don't drop out: The impact of neo-liberalism on magic mushroom users' (in)ability to imagine collectivist social worlds
    Sarah Riley
    University of Bath, Bath BA2 7AY, UK
    Int J Drug Policy 21:445-51. 2010
    ..During and after this time there has been relatively little analysis concerning how magic mushroom users accounted for their drug use, nor on the wider political and cultural discourses that might have shaped this sense making...
  55. ncbi Micro-solid phase extraction coupled with high-performance liquid chromatography-tandem mass spectrometry for the determination of stimulants, hallucinogens, ketamine and phencyclidine in oral fluids
    Manuel Sergi
    Department of Food Science, University of Teramo, Via Carlo Lerici 1, 64023 Mosciano Stazione, Teramo, Italy
    Anal Chim Acta 675:132-7. 2010
    ..methylenedioxymethylamphetamine, cocaine, benzoylecgonine, ketamine, mescaline, phencyclidine and psilocybine were analyzed...
  56. ncbi Forensic analysis of hallucinogenic mushrooms and khat (Catha edulis Forsk) using cation-exchange liquid chromatography
    Tim Laussmann
    Centre for Education and Science of the Federal Finance Administration, Customs Laboratory Cologne, Cologne, Germany
    Forensic Sci Int 195:160-4. 2010
    ..Additionally, the sample treatment for fresh mushroom and khat samples has been optimised. Highest amounts of alkaloids were found when fresh material was freeze-dried...
  57. ncbi Availability of websites offering to sell psilocybin spores and psilocybin
    Jason P Lott
    Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, 3820 Locust Walk MB 36, Philadelphia, PA 19104, USA
    J Psychoactive Drugs 41:305-7. 2009
    ..Additional studies are needed to assess whether websites offering to sell psilocybin and psilocybin spores actually deliver their products as advertised...
  58. ncbi Comparative study of ATR and transflection IR spectroscopic techniques for the analysis of hallucinogenic mushrooms
    A Kocak
    John Jay College of Criminal Justice, The City University of New York, Department of Sciences, New York, NY 10019, USA
    Forensic Sci Int 195:36-41. 2010
    ..Both techniques gave comparable results and agreed with prior GC/MS analysis of the actual case samples...
  59. pmc Analysis of mushroom exposures in Texas requiring hospitalization, 2005-2006
    George Barbee
    Department of Emergency Medicine, Womack Army Medical Center, Fort Bragg, NC, USA
    J Med Toxicol 5:59-62. 2009
    ..Texas has approximately 200 species of wild mushrooms, including toxic and hallucinogenic varieties. Mushroom ingestions in Texas were studied for 2005-2006...
  60. pmc Psilocybin-induced stimulus control in the rat
    J C Winter
    Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
    Pharmacol Biochem Behav 87:472-80. 2007
    ..In addition, psilocybin differs from closely related hallucinogens such as 5-MeO-DMT in that agonism at 5-HT(1A) receptors appears to play no role in psilocybin-induced stimulus control...
  61. ncbi Strategies for the capillary electrophoretic separation of indole alkaloids in Psilocybe semilanceata
    S Pedersen-Bjergaard
    School of Pharmacy, University of Oslo, Norway
    Electrophoresis 19:27-30. 1998
    ..Psilocin was difficult to analyze by CZE at pH 11.5 owing to comigration with the electroosmotic flow. For this compound, the pH of the running buffer was reduced to 7.2 to effectively enhance the electrophoretic mobility...
  62. ncbi The pharmacology of psilocybin
    Torsten Passie
    Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Addict Biol 7:357-64. 2002
    ..Because of its still growing capacity for abuse and the widely dispersed data this review presents all the available pharmacological data about psilocybin...
  63. ncbi Optimized glucuronide hydrolysis for the detection of psilocin in human urine samples
    Tooru Kamata
    Forensic Science Laboratory, Osaka Prefectural Police H Q, 1 3 18 Hommachi, Chuo Ku, Osaka 541 0053, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 796:421-7. 2003
    ..According to the present method, 3.55 microg/ml of psilocin was detected in the "magic mushroom" user's urine after the enzymatic hydrolysis, though psilocin was not detected without hydrolysis...
  64. ncbi Mushrooms: toxins right in your own backyard
    Allison A Muller
    The Poison Control Center, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Emerg Nurs 29:483-5. 2003
  65. ncbi [Levels of psilocybin and psilocin in various types of mushrooms]
    J Stríbrný
    Ustav leteckého zdravotnictví, Gen Piky 1, Praha 6, 160 60
    Soud Lek 48:45-9. 2003
    ..The results of this study prove the presence of at least three species of Psilocybe with a high content of psychoactive components growing in our republic: Psilocybe semilanceata, Psilocybe bohemica and Psilocybe arcana...
  66. ncbi Morphological and chemical analysis of magic mushrooms in Japan
    Kenji Tsujikawa
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Forensic Sci Int 138:85-90. 2003
    ..43-0.76%/0.08-0.22% in the whole mushroom (0.64-0.74%/0.02-0.22% in the cap and 0.31-0.78%/0.01-0.39% in the stem). It thus appears that P. cubensis is psilocybin-rich, whereas Copelandia is psilocin-rich...
  67. ncbi Evaluation of a procedure to assess the adverse effects of illicit drugs
    J G C van Amsterdam
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Regul Toxicol Pharmacol 39:1-4. 2004
    ..acid (GHB), and 4-methylthio-amphetamine (MTA) were assessed as more adverse than ketamine and psilocine and psilocybine-containing mushrooms...
  68. ncbi Forensic analysis of hallucinogenic fungi: a DNA-based approach
    Kimberly G Nugent
    Department of Botany, University of Toronto at Mississauga, 3349 Mississauga Road North, Mississauga, Ont, Canada L5L 1C6
    Forensic Sci Int 140:147-57. 2004
    ..With this information, we propose an approach that combines the specificity of PCR detection and the resolving power of phylogenetic analysis to efficiently and unambiguously identify hallucinogenic fungal specimens for legal purposes...
  69. ncbi Poly(dimethylsiloxane) electrospray devices fabricated with diamond-like carbon-poly(dimethylsiloxane) coated SU-8 masters
    K Huikko
    Department of Pharmacy, PO Box 56, FIN 00014, University of Helsinki, Finland
    Lab Chip 3:67-72. 2003
    ..The performance of PDMS devices was examined in the ESI-MS analysis of some pharmaceutical compounds and amino acids...
  70. ncbi Concise large-scale synthesis of psilocin and psilocybin, principal hallucinogenic constituents of "magic mushroom"
    Osamu Shirota
    Division of Pharmacognosy, Phytochemistry and Narcotics, and Division of Organic Chemistry, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    J Nat Prod 66:885-7. 2003
    ..The key step in the synthesis of 2 was the isolation of the dibenzyl-protected intermediate (7) as a zwitterionic derivative (8), which was completely identified by means of 2D NMR analyses...
  71. ncbi [Discrimination of psychoactive fungi (commonly called "magic mushrooms") based on the DNA sequence of the internal transcribed spacer region]
    Takuro Maruyama
    National Institute of Health Sciences 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Shokuhin Eiseigaku Zasshi 44:44-8. 2003
    ..Analysis by LC revealed that psilocin (1) was contained at the highest level in Panaeolus cyanescens among the MMs, but was absent in the Amanita species...
  72. ncbi Effects of the 5-HT2A agonist psilocybin on mismatch negativity generation and AX-continuous performance task: implications for the neuropharmacology of cognitive deficits in schizophrenia
    Daniel Umbricht
    Psychiatric University Hospital of Zurich Department of Research, Switzerland
    Neuropsychopharmacology 28:170-81. 2003
    ..Comparable deficits in schizophrenia may result from independent dysfunctions of 5-HT(2A) and NMDAR-related neurotransmission...
  73. ncbi Effects of the hallucinogen psilocybin on habituation and prepulse inhibition of the startle reflex in humans
    E Gouzoulis Mayfrank
    Department of Psychiatry and Psychotherapy, University of Technology RWTH, Aachen, Germany
    Behav Pharmacol 9:561-6. 1998
    ....
  74. ncbi Hallucinogenic mushrooms on the German market - simple instructions for examination and identification
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111, Bonn, Germany
    Forensic Sci Int 113:389-95. 2000
    ..The alkaloid content was determined with <0.003-1.15% of psilocybin and 0.01-0.90% psilocin. Panaeolus cyanescens was the mushroom with highest levels of psilocybin and psilocin...
  75. ncbi [Psychoactive mushrooms - an update]
    T Supprian
    Universitäts Nervenklinik und Poliklinik, Psychiatrie und Psychotherapie, Homburg Saar
    Fortschr Neurol Psychiatr 69:597-602. 2001
    ..In Germany, dried specimens are sold as "Duftkissen" (aroma pads). The article reviews the common psychoactive species and illustrates medical risks...
  76. ncbi Possible mechanisms of panic attack and schizophrenia via APUD system
    K Fukuda
    Department of Medicine, Tokyo Women s Medical University Daini Hospital, Japan
    Med Hypotheses 58:123-6. 2002
    ..Schizophrenia might be due to the massive destruction of APUD cells, and the paroxysmal release of 5-HT with peptides and panneuroendocrine markers from NEB might be the cause of panic attack...
  77. ncbi Synthetic studies of psilocin analogs having either a formyl group or bromine atom at the 5- or 7-position
    Fumio Yamada
    Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    Chem Pharm Bull (Tokyo) 50:92-9. 2002
    ....
  78. ncbi Effects of nebulizing and drying gas flow on capillary electrophoresis/mass spectrometry
    Katri Huikko
    Viikki Drug Discovery Technology Center, Department of Pharmacy, P O Box 56, FIN 00014 University of Helsinki, Helsinki, Finland
    Rapid Commun Mass Spectrom 16:1562-8. 2002
    ..Moreover, the effect of gas flow on CE separation should be studied when optimizing the CE /MS operation parameters...
  79. ncbi Jekyll and Hyde revisited: paradoxes in the appreciation of drug experiences and their effects on creativity
    Jos ten Berge
    Faculteit der Letteren, Vrije Universiteit, Amsterdam, The Netherlands
    J Psychoactive Drugs 34:249-62. 2002
    ..It seems that the "demoniacal" and "psychedelic" mode come together in experiential reality, only to be divided in the cultural sphere...
  80. ncbi Psychotropic drugs in developmental mushrooms: a case study review
    Susan T Gross
    Minnesota Forensic Science Laboratory, St Paul 55104, USA
    J Forensic Sci 47:1298-302. 2002
    ..Each case contained different stages of developing mushrooms. This report describes the evidence in each case, the sample preparation, the sample analysis and the final report that was written...
  81. ncbi Psychedelic drugs: the ups and downs of ecstasy
    Erika Check
    Nature 429:126-8. 2004
  82. ncbi The Meixner test in the detection of alpha-amanitin and false-positive reactions caused by psilocin and 5-substituted tryptamines
    Michael Beuhler
    Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, AZ, USA
    Ann Emerg Med 44:114-20. 2004
    ..We attempted to determine the detection limit of the Meixner test for alpha-amanitin and to determine the percentage of positive sample interpretation compared with other mushroom indole compounds...
  83. ncbi Psilocybin impairs high-level but not low-level motion perception
    Olivia L Carter
    Vision Touch and Hearing Research Center, School of Biomedical Sciences, University of Queensland, Australia
    Neuroreport 15:1947-51. 2004
    ....
  84. ncbi The determination of psilocin and psilocybin in hallucinogenic mushrooms by HPLC utilizing a dual reagent acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence detection system
    Nicole Anastos
    School of Biological and Chemical Sciences, Deakin University, Geelong, VIC 3217, Australia
    J Forensic Sci 51:45-51. 2006
    ..2 x 10(-8) and 3.5 x 10(-9) mol/L being obtained for psilocin and psilocybin, respectively. The procedure was applied to the determination of psilocin and psilocybin in three Australian species of hallucinogenic mushroom...
  85. ncbi Response of cluster headache to psilocybin and LSD
    R Andrew Sewell
    Clinical Research Laboratory, Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neurology 66:1920-2. 2006
    ..Research on the effects of psilocybin and LSD on cluster headache may be warranted...
  86. ncbi Application of ion mobility spectrometry in cases of forensic interest
    Thomas Keller
    Institute of Forensic Medicine, University of Salzburg, Austria
    Forensic Sci Int 161:130-40. 2006
    ..A new application of the IMS technology for the analysis of postmortem sweat samples for drugs is also presented...
  87. ncbi Psilocin identified in a DUID investigation
    Nicholas B Tiscione
    Florida Department of Law Enforcement, Orlando Regional Operations Center, 500 West Robinson Street, Orlando, Florida 32801, USA
    J Anal Toxicol 30:342-5. 2006
    ..Hydrolysis and derivatization techniques were not employed. The urine concentration of psilocin decreased rapidly, although the specimen was maintained at 4 degrees C...
  88. ncbi Investigation into the temporal stability of aqueous standard solutions of psilocin and psilocybin using high performance liquid chromatography
    N Anastos
    School of Biological and Chemical Sciences, Deakin University, Geelong, VIC 3217, Australia
    Sci Justice 46:91-6. 2006
    ..It was found that the exclusion of light significantly prolonged the useful life of standards, with aqueous solutions of both psilocin and psilocybin being stable over a period of seven days...
  89. ncbi [Chronic cluster headache: Response to psilocybin]
    A P Sempere
    Rev Neurol 43:571-2. 2006
  90. ncbi Not imagining it. Research into hallucinogens cautiously resumes
    David Biello
    Sci Am 295:33-5. 2006
  91. ncbi 5-Year trends in use of hallucinogens and other adjunct drugs among UK dance drug users
    Jim McCambridge
    National Addiction Centre, Institute of Psychiatry, King s College London, London, UK
    Eur Addict Res 13:57-64. 2007
    ..To describe and assess trends in the use of hallucinogens and other adjunct drugs over a 5-year period...
  92. ncbi Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder
    Francisco A Moreno
    Department of Psychiatry, University of Arizona, Tucson, USA
    J Clin Psychiatry 67:1735-40. 2006
    ..This modified double-blind study investigated the safety, tolerability, and clinical effects of psilocybin, a potent 5-HT(1A) and 5-HT(2A/2C) agonist, in patients with OCD...
  93. ncbi [Hallucinogenic mushrooms]
    Dagmara Reingardiene
    Clinic of Intensive Therapy, Kaunas University of Medicine, Kaunas, Lithuania
    Medicina (Kaunas) 41:1067-70. 2005
    ....
  94. ncbi Development of a psilocin immunoassay for serum and blood samples
    C Albers
    Institute of Pharmaceutical and Medicinal Chemistry, University of Munster, Hittorfstrasse 58 62, 48149 Munster, Germany
    Int J Legal Med 118:326-31. 2004
    ..Spiked serum and blood samples were analysed with this new immunoassay and the results obtained were compared with the values measured with a validated GC-MS method...
  95. ncbi Liquid chromatography-mass spectrometric and liquid chromatography-tandem mass spectrometric determination of hallucinogenic indoles psilocin and psilocybin in "magic mushroom" samples
    Tooru Kamata
    Forensic Science Laboratory, Osaka Prefectural Police H Q, 1 3 18, Hommachi, Chuo Ku, Osaka 541 0053, Japan
    J Forensic Sci 50:336-40. 2005
    ..By applying the present LC-MS-MS technique to four real samples, the contents of PC and PB were found to vary over a wide range (0.60-1.4 and 0.18-3.8 mg/g dry wt. for PC and PB, respectively) between samples...
  96. ncbi Hallucinogen persisting perception disorder after psilocybin consumption: a case study
    Marie Laure Espiard
    Centre Esquirol, Centre Hospitalier Universitaire de Caen, 14033 Caen Cedex, France
    Eur Psychiatry 20:458-60. 2005
    ..This report shows symptomatic recurrences persisting more than 8 months. Various differential diagnoses were evoked and our therapeutic strategies were described...
  97. ncbi SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist
    Howard Sard
    Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
    Bioorg Med Chem Lett 15:4555-9. 2005
    ..These results suggest a new area for development of novel 5-HT(2C) agonists with applications for drug discovery...
  98. ncbi Poisonings resulting from the ingestion of magic mushrooms in Kraków
    Leszek Satora
    Poison Information Centre, Jagiellonian University Medical College Kraków, Poland
    Przegl Lek 62:394-6. 2005
    ..The main source of information for patients about hallucinogenic mushrooms was the internet. In the cases discussed the mushroom poisoning caused no organ damage and the symptoms disappeared in about 6 hours...
  99. ncbi Using psilocybin to investigate the relationship between attention, working memory, and the serotonin 1A and 2A receptors
    Olivia L Carter
    University of Queensland, Australia
    J Cogn Neurosci 17:1497-508. 2005
    ..The clinical relevance of these results is also discussed...
  100. ncbi Severe rhabdomyolysis, acute renal failure and posterior encephalopathy after 'magic mushroom' abuse
    Markus Bickel
    Department of Internal Medicine ICU, J W Goethe University, Frankfurt, Germany
    Eur J Emerg Med 12:306-8. 2005
    ..Magic mushrooms are becoming increasingly fashionable among drug users, as they are believed to be more harmless than other hallucinogenic designer drugs. So far, little is known about their possible severe side effects...
  101. ncbi [Hallucinogenic fungi (Psylocibe). Part I. Characteristics, results of consumption, recognition]
    Jerzy Janoszka
    Akademia Medyczna we Wrocławiu, Katedra Medycyny Sadowej Zakład Technik Molekularnych
    Arch Med Sadowej Kryminol 55:215-9. 2005
    ..wild fungi tissue, but a select type of mycelium from a glass culture may have significantly higher contents of psilocybine. The effective time on the human brain is about 4-5 hours...

Research Grants8

  1. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 2002
    ....
  2. BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
    JERROLD WINTER; Fiscal Year: 2005
    ..abstract_text> ..
  3. Tryptophan Depletion: A Phenotypic Marker for Depression
    Francisco Moreno; Fiscal Year: 2007
    ..Compelling pilot data are presented to support the study feasibility and validity of the proposed hypotheses. [unreadable] [unreadable]..
  4. Indole Analogs as Novel Treatments for OCD
    Howard Sard; Fiscal Year: 2008
    ..Such leads will also display favorable drug-like properties. The long term goal of this project is to discover a new, improved pharmaceutical agent for treatment of OCD that can be licensed and developed for ultimate market approval. ..
  5. REVAMP Follow-Up Study
    Francisco Moreno; Fiscal Year: 2008
    ....
  6. 12-Step Facilitation for the Dually Diagnosed
    Michael Bogenschutz; Fiscal Year: 2009
    ..abstract_text> ..
  7. Behavioral and Pharmacological Analysis of Drugs of Abuse
    JERROLD WINTER; Fiscal Year: 2008
    ..This likelihood coupled with continued interest in the therapeutic use of agents such as psilocybin makes a detailed pharmacological assessment of these drugs of utmost importance. ..
  8. Effects of self-administered MDMA on brain and behavior in rhesus monkeys
    William Fantegrossi; Fiscal Year: 2007
    ..Thus, these studies are likely to be more relevant to the potential human condition of MDMA-induced lasting neurochemical alterations and behavioral changes [unreadable] [unreadable]..