indole alkaloids

Summary

Summary: Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)

Top Publications

  1. ncbi Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220
    Feng Yu Du
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
    Bioorg Med Chem Lett 22:4650-3. 2012
  2. ncbi Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete
    Wenjun Zhang
    CAS Key Laboratory of Marine Bio resources Sustainable Utilization, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
    Org Lett 14:3364-7. 2012
  3. ncbi Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog
    L F Rocha E Silva
    National Institute for Amazonian Research, Av André Araújo 2936, Aleixo, 69060 001 Manaus, Amazonas, Brazil
    Phytomedicine 20:71-6. 2012
  4. ncbi Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth
    Nanami Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 151:3006-14. 2010
  5. pmc Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival
    Hussein Akil
    Universite de Limoges, Laboratoire EA 3842, Homéostasie Cellulaire et Pathologies, Faculte de Medecine et de Pharmacie, Limoges, France
    PLoS ONE 6:e25097. 2011
  6. ncbi Anti-inflammatory effects and mechanisms of the ethanol extract of Evodia rutaecarpa and its bioactive components on neutrophils and microglial cells
    Han Chieh Ko
    National Research Institute of Chinese Medicine, Taiwan
    Eur J Pharmacol 555:211-7. 2007
  7. ncbi Ipobscurines C and D: macrolactam-type indole alkaloids from the seeds of Ipomoea obscura
    Kristina Jenett-Siems
    Institut für Pharmazie Pharmazeutische Biologie, Freie Universitat Berlin, Konigin Luise Str 2 4, D 14195 Berlin, Germany
    Phytochemistry 62:1257-63. 2003
  8. pmc Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids
    Jennifer M Finefield
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    J Nat Prod 75:812-33. 2012
  9. ncbi Indole alkaloids and other constituents of Rauwolfia serpentina
    Atsuko Itoh
    Kobe Pharmaceutical University, Higashinada ku, Japan
    J Nat Prod 68:848-52. 2005
  10. ncbi 5-hydroxytryptamine-derived alkaloids from two marine sponges of the genus Hyrtios
    Mostafa Salmoun
    Laboratory of Bio organic Chemistry, Department of Organic Chemistry, Faculty of Sciences, CP 160 06, University of Brussels, 50 Av F D Roosevelt, Belgium
    J Nat Prod 65:1173-6. 2002

Detail Information

Publications295 found, 100 shown here

  1. ncbi Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220
    Feng Yu Du
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
    Bioorg Med Chem Lett 22:4650-3. 2012
    Four new indole alkaloids, namely, cristatumins A-D (1-4), along with six known congeners (5-10) were identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus isolated from the marine alga Sargassum ..
  2. ncbi Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete
    Wenjun Zhang
    CAS Key Laboratory of Marine Bio resources Sustainable Utilization, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
    Org Lett 14:3364-7. 2012
    ..Spiroindimicins B-D (2-4) with a [5,5] spiro-ring exhibited moderate cytotoxicities against several cancer cell lines...
  3. ncbi Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog
    L F Rocha E Silva
    National Institute for Amazonian Research, Av André Araújo 2936, Aleixo, 69060 001 Manaus, Amazonas, Brazil
    Phytomedicine 20:71-6. 2012
    b>Indole alkaloids ellipticine (1), cryptolepine triflate (2a), rationally designed 11-(4-piperidinamino)cryptolepine hydrogen dichloride (2b) and olivacine (3) (an isomer of 1) were evaluated in vitro against Plasmodium falciparum and in ..
  4. ncbi Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth
    Nanami Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 151:3006-14. 2010
    ..Thus, autocrine signaling of the BDNF/TrkB system is important for human choriocarcinoma cell growth, and inhibition of BDNF/TrkB signaling in these cells could provide a novel therapy for patients with choriocarcinoma...
  5. pmc Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival
    Hussein Akil
    Universite de Limoges, Laboratoire EA 3842, Homéostasie Cellulaire et Pathologies, Faculte de Medecine et de Pharmacie, Limoges, France
    PLoS ONE 6:e25097. 2011
    ..They were recently detected in some cancers in association with invasiveness, but the function of these tyrosine kinase receptors was not previously investigated in colorectal cancer (CRC) cells...
  6. ncbi Anti-inflammatory effects and mechanisms of the ethanol extract of Evodia rutaecarpa and its bioactive components on neutrophils and microglial cells
    Han Chieh Ko
    National Research Institute of Chinese Medicine, Taiwan
    Eur J Pharmacol 555:211-7. 2007
    ....
  7. ncbi Ipobscurines C and D: macrolactam-type indole alkaloids from the seeds of Ipomoea obscura
    Kristina Jenett-Siems
    Institut für Pharmazie Pharmazeutische Biologie, Freie Universitat Berlin, Konigin Luise Str 2 4, D 14195 Berlin, Germany
    Phytochemistry 62:1257-63. 2003
    Separation of the methanolic seed extract of Ipomoea obscura afforded five indole alkaloids, three of them (ipobscurines B-D) being new natural products of a unique structural type characterized as serotonin hydroxycinnamic acid amide-..
  8. pmc Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids
    Jennifer M Finefield
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    J Nat Prod 75:812-33. 2012
    ..2.2]diazaoctane ring system. Furthermore, the diverse fungal origin of these natural products is closely examined and, in many cases, updated to reflect the currently accepted fungal taxonomy...
  9. ncbi Indole alkaloids and other constituents of Rauwolfia serpentina
    Atsuko Itoh
    Kobe Pharmaceutical University, Higashinada ku, Japan
    J Nat Prod 68:848-52. 2005
    From the dried roots of Rauwolfia serpentina were isolated five new indole alkaloids, N(b)-methylajmaline (1), N(b)-methylisoajmaline (2), 3-hydroxysarpagine (3), yohimbinic acid (4), isorauhimbinic acid (5), a new iridoid glucoside, 7-..
  10. ncbi 5-hydroxytryptamine-derived alkaloids from two marine sponges of the genus Hyrtios
    Mostafa Salmoun
    Laboratory of Bio organic Chemistry, Department of Organic Chemistry, Faculty of Sciences, CP 160 06, University of Brussels, 50 Av F D Roosevelt, Belgium
    J Nat Prod 65:1173-6. 2002
    ..H. reticulatus contained the novel derivative 1,6-dihydroxy-1,2,3,4-tetrahydro-beta-carboline (11) together with serotonin (5), 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-beta-carboline (7), and 6-hydroxy-3,4-dihydro-1-oxo-beta-carboline (9)...
  11. ncbi Synthesis and study of a molecularly imprinted polymer for the specific extraction of indole alkaloids from Catharanthus roseus extracts
    C Lopez
    Institut de Chimie Organique et Analytique, Université d Orléans CNRS FR 2708 UMR 6005, Orleans, France
    Anal Chim Acta 683:198-205. 2011
    ..MIP) for catharanthine and vindoline have been synthesized in order to specifically extract these natural indole alkaloids from Catharanthus roseus by solid-phase extraction (SPE)...
  12. ncbi Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp
    Baoquan Bao
    College of Pharmacy, Pusan National University, Busan 609 735, Korea
    J Nat Prod 68:711-5. 2005
    ..Compounds 1, 4, 5, and 11 showed moderate to significant cytotoxicity against five human tumor cell lines, and compounds 1-5 showed weak antibacterial activity against clinically isolated methicillin-resistant strains...
  13. ncbi Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus
    Pierre Sauleau
    Laboratoire de Chimie et Biochimie des Substances Naturelles, MNHN, UMR 5154 CNRS, 57 rue Cuvier Case Postale 54, 75005 Paris, France
    J Nat Prod 69:1676-9. 2006
    ..Hyrtiosulawesine (1) displayed a significant antiphospholipase A2 activity with an IC50 value of 14 microM in a fluorometric assay using Crotalus adamanteus venom phospholipase A2...
  14. ncbi Enantioselective synthesis of stephacidin B
    Seth B Herzon
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 127:5342-4. 2005
    ..We also obtained evidence that 2 can form 1 under mild conditions, and that 2 reacts with nucleophiles, such as methanol, by conjugate addition...
  15. ncbi Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus
    Min Chen
    Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People s Republic of China
    J Nat Prod 76:547-53. 2013
    Two new prenylated indole alkaloids, 17-epi-notoamides Q and M (1 and 2), and two new phenyl ether derivatives, cordyols D and E (9 and 13), together with 10 known compounds (3-8, 10-12, 14) were isolated from a marine-derived Aspergillus ..
  16. ncbi Potential antimalarial activity of indole alkaloids
    Michel Frederich
    Universite de Liege, Centre Interfacultaire de Recherche du Médicament CIRM, Departement de Pharmacie, CHU Tour 4 Bâtiment B36, Avenue de l Hopital, 1 B4000 Liège, Belgium
    Trans R Soc Trop Med Hyg 102:11-9. 2008
    ..Among the natural products, indole alkaloids represent an interesting class of compounds...
  17. pmc Aplysinopsins--marine indole alkaloids: chemistry, bioactivity and ecological significance
    Dobroslawa Bialonska
    Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677 1848, USA
    Mar Drugs 7:166-83. 2009
    ..This review summarizes 30 years' research on aplysinopsins. The origin, isolation sources, chemistry, bioactivity, and ecological functions of aplysinopsins are comprehensively reviewed...
  18. ncbi Calcitonin gene-related peptide-mediated antihypertensive and anti-platelet effects by rutaecarpine in spontaneously hypertensive rats
    Dai Li
    Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China
    Peptides 29:1781-8. 2008
    ....
  19. pmc Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway
    Y H Zhang
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Physiol 586:3113-27. 2008
    ..Neurotrophins released upon activation of a variety of immuno-competent cells may be important mediators that give rise to the enhanced neuronal sensitivity associated with the inflammatory response...
  20. ncbi Synthesis and vasodilator effects of rutaecarpine analogues which might be involved transient receptor potential vanilloid subfamily, member 1 (TRPV1)
    Zhuo Chen
    Chemistry Section, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, No 172, Tong Zi Po Road, Changsha 410013, Hunan, China
    Bioorg Med Chem 17:2351-9. 2009
    ..The vasodilator effects of these compounds were evaluated and the structure-activity relationship was elucidated for the first time. The results suggested a new direction of valuable TRPV1 agonist as anti-hypertensive drugs...
  21. ncbi Calcitonin gene-related peptide mediates the cardioprotective effects of rutaecarpine against ischaemia-reperfusion injury in spontaneously hypertensive rats
    Dai Li
    Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, China
    Clin Exp Pharmacol Physiol 36:662-7. 2009
    ....
  22. pmc Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx
    Jing Du
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892 4480, USA
    J Cell Biol 163:385-95. 2003
    ..These results demonstrate an activity- and Ca2+-dependent modulation of TrkB tyrosine kinase and its internalization, and they provide new insights into the cell biology of tyrosine kinase receptors...
  23. ncbi Fumigaclavine C improves concanavalin A-induced liver injury in mice mainly via inhibiting TNF-alpha production and lymphocyte adhesion to extracellular matrices
    Ying Zhao
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    J Pharm Pharmacol 56:775-82. 2004
    ....
  24. ncbi Actinophyllic acid, a potent indole alkaloid inhibitor of the coupled enzyme assay carboxypeptidase u/hippuricase from the leaves of Alstonia actinophylla (Apocynaceae)
    Anthony R Carroll
    Natural Product Discovery, Eskitis Institute, Griffith University, Brisbane, Australia 4111
    J Org Chem 70:1096-9. 2005
    ..84 microM. Actinophyllic acid possesses a unique 2,3,6,7,9,13c-hexahydro-1H-1,7,8-(methanetriyloxymethano)pyrrolo[1',2':1,2]azocino[4,3-b]indole-8(5H)-carboxylic acid skeleton...
  25. ncbi Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity
    Mariko Kitajima
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Bioorg Med Chem Lett 21:1962-4. 2011
    Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity...
  26. ncbi Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids
    Toh Seok Kam
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Bioorg Med Chem Lett 14:4487-9. 2004
    A series of indole alkaloids of the ibogan-type was assessed for their cytotoxic effects as well as their potential in reversing MDR in vincristine-resistant KB cells...
  27. ncbi Metabolic engineering of cell cultures versus whole plant complexity in production of bioactive monoterpene indole alkaloids: recent progress related to old dilemma
    Giancarlo Pasquali
    Programa de Pós Graduação em Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av Bento Goncalves 9500, Pr 43 431, P O Box 15 005, CEP 91 501 970, Porto Alegre, RS, Brazil
    J Biosci Bioeng 101:287-96. 2006
    Monoterpene indole alkaloids (MIAs) are a large class of plant alkaloids with significant pharmacological interest. The sustained production of MIAs at high yields is an important goal in biotechnology...
  28. pmc Concise, stereocontrolled synthesis of the citrinadin B core architecture
    Carlos A Guerrero
    Frick Laboratory, Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    Org Lett 13:5164-7. 2011
    ....
  29. ncbi Fumigaclavine C inhibits tumor necrosis factor α production via suppression of toll-like receptor 4 and nuclear factor κB activation in macrophages
    Rong Hui Du
    School of Medicine, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China
    Life Sci 89:235-40. 2011
    ..In the current study, we investigated the anti-inflammatory action of the fungal alkaloid fumigaclavine C (FC), its effects on the TLR4 and NFκB signaling pathway, and its potential relevance as an anti-atherosclerotic agent...
  30. ncbi Bioactive alkaloids from endophytic Aspergillus fumigatus
    Hui Ming Ge
    Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People s Republic of China
    J Nat Prod 72:753-5. 2009
    ..Furthermore, 14-norpseurotin (4) significantly induced neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration...
  31. ncbi An enantioselective total synthesis and stereochemical revision of (+)-citrinadin B
    Ke Kong
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80532 1872, USA
    J Am Chem Soc 135:10890-3. 2013
    ..The synthesis is convergent and employs a stereoselective intermolecular nitrone cyloaddition reaction as a key step. ..
  32. ncbi Synthesis and biological properties of benzo-annulated rutaecarpines
    Young Hwan Hong
    College of Pharmacy, Yeungnam University, Gyeongsan 712 749, Korea
    Biol Pharm Bull 33:1704-9. 2010
    ..Benzo-annulation on ring A led to significant increase of inhibitory activity against topo II while annulations on ring E increased inhibitory activity against topo I...
  33. ncbi Chemistry and biology of monoterpene indole alkaloid biosynthesis
    SARAH E O'CONNOR
    Department of Chemistry, Massachusetts Institute of Technology, Building 18 592, Cambridge, MA 02139 4307, USA
    Nat Prod Rep 23:532-47. 2006
  34. ncbi Citrinadin A, a novel pentacyclic alkaloid from marine-derived fungus Penicillium citrinum
    Masashi Tsuda
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Org Lett 6:3087-9. 2004
    ....
  35. ncbi Antileishmanial activity of indole alkaloids from Aspidosperma ramiflorum
    J C A Tanaka
    Departamento de Química da Universidade Estadual de Maringá, Maringa, PR, Brasil
    Phytomedicine 14:377-80. 2007
    ..amazonensis (LD(50) values of 16.3+/-1.6 microg/ml and 4.9+/-0.9 microg/ml, respectively). Our results are promising, showing that these compounds are biologically active against Gram-positive bacteria...
  36. ncbi Neolamarckines A and B, new indole alkaloids from Neolamarckia cadamba
    Ahmad Kaleem Qureshi
    Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    Chem Pharm Bull (Tokyo) 59:291-3. 2011
    Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae)...
  37. ncbi Two new cytotoxic isomeric indole alkaloids from the roots of Nauclea orientalis
    Jirapast Sichaem
    Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand
    Fitoterapia 81:830-3. 2010
    A pair of new isomeric indole alkaloids, naucleaorals A (1) and B (2) were isolated from the roots of Nauclea orientalis...
  38. ncbi Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats
    Po Ling Yu
    Department of Surgery, Taipei City Hospital, Taipei 10431, Taiwan, Republic of China
    J Cell Biochem 108:469-75. 2009
    ....
  39. ncbi New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
    Seung Ill Kim
    College of Pharmacy, Yeungnam University, Gyeongsan, Korea
    Arch Pharm Res 35:785-9. 2012
    ..Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II...
  40. ncbi Antithrombotic effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, on platelet plug formation in in vivo experiments
    J R Sheu
    Graduate Institute of Medical Sciences, Department of Surgery, Taipei Medical College, Taiwan
    Br J Haematol 110:110-5. 2000
    ..These results suggest that rutaecarpine has an effective anti-platelet effect in vivo and that it may be a potential therapeutic agent for arterial thrombosis, but it must be assessed further for toxicity...
  41. ncbi Rapid modulation of inhibitory synaptic currents in cerebellar Purkinje cells by BDNF
    Rosemarie Drake-Baumann
    Neurology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Synapse 57:183-90. 2005
    ....
  42. ncbi Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus
    Rumi Yamanokuchi
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Bioorg Med Chem 20:4437-42. 2012
    ..So far, only five E1 inhibitors, panapophenanthrine, himeic acid A, largazole, and hyrtioreticulins A and B (1 and 2), have been isolated from natural sources and, among them, 1 is the most potent E1 inhibitor...
  43. ncbi Antibacterial activity of indole alkaloids from Aspidosperma ramiflorum
    J C A Tanaka
    Departamento de Quimica, Universidade Estadual de Maringa, Maringa, PR, Brazil
    Braz J Med Biol Res 39:387-91. 2006
    ..faecalis (MIC = 50 microg/mL), with EC50 of 8 and 2.5 microg/mL for ramiflorines A and B, respectively, against S. aureus. These results are promising, showing that these compounds are biologically active against Gram-positive bacteria...
  44. ncbi Alstilobanines A-E, new indole alkaloids from Alstonia angustiloba
    Koichiro Koyama
    Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2 4 41, Shinagawa ku, Tokyo 142 8501, Japan
    Bioorg Med Chem 16:6483-8. 2008
    ..Alstilobanines A-E showed a moderate vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta...
  45. ncbi Absolute stereochemistry of citrinadins a and B from marine-derived fungus
    Takao Mugishima
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Org Chem 70:9430-5. 2005
    ....
  46. ncbi Reverse prenyltransferase in the biosynthesis of fumigaclavine C in Aspergillus fumigatus: gene expression, purification, and characterization of fumigaclavine C synthase FGAPT1
    Inge A Unsöld
    Eberhard Karls Universitat Tubingen, Pharmazeutische Biologie, Auf der Morgenstelle 8, 72076 Tubingen, Germany
    Chembiochem 7:158-64. 2006
    ..Surprisingly, it shows very low sequence similarity to the recently identified prenyltransferase LtxC from cyanobacteria, which also catalyzes the reverse prenylation of an indole nucleus...
  47. ncbi Functional analysis of an indole-diterpene gene cluster for lolitrem B biosynthesis in the grass endosymbiont Epichloë festucae
    Sanjay Saikia
    Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    FEBS Lett 586:2563-9. 2012
    ..festucae and in cells of Penicillium paxilli containing copies of these genes under the control of a P. paxilli biosynthetic gene promoter. We propose a biosynthetic scheme to account for this metabolic diversity...
  48. ncbi Strategies for engineering plant natural products: the iridoid-derived monoterpene indole alkaloids of Catharanthus roseus
    SARAH E O'CONNOR
    John Innes Centre, Department of Biological Chemistry, Norwich Research Park, Norwich, United Kingdom
    Methods Enzymol 515:189-206. 2012
    ..The iridoid-derived monoterpene indole alkaloids from C...
  49. ncbi Glial cell line-derived neurotrophic factor modulates the excitability of nociceptive trigeminal ganglion neurons via a paracrine mechanism following inflammation
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 28:100-7. 2013
    ..GDNF paracrine mechanism could be important as a therapeutic target for trigeminal inflammatory hyperalgesia...
  50. ncbi Chemical composition of Aspidosperma ulei Markgr. and antiplasmodial activity of selected indole alkaloids
    Zelina Estevam Dos Santos Torres
    Instituto Nacional de Pesquisas da Amazonia, Caixa Postal 2223 CEP 69080 971, Manaus, Amazonas, Brasil
    Molecules 18:6281-97. 2013
    A new indole alkaloid, 12-hydroxy-N-acetyl-21(N)-dehydroplumeran-18-oic acid (13), and 11 known indole alkaloids: 3,4,5,6-tetradehydro-β-yohimbine (3), 19(E)-hunteracine (4), β-yohimbine (5), yohimbine (6), 19,20-dehydro-17-α-yohimbine ..
  51. ncbi Hyrtioerectines A-C, cytotoxic alkaloids from the red sea sponge hyrtioserectus
    Diaa T A Youssef
    Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
    J Nat Prod 68:1416-9. 2005
    ..Hyrtioerectines A-C were moderately cytotoxic...
  52. pmc Enantioselective total synthesis of (-)-citrinadin A and revision of its stereochemical structure
    Zhiguo Bian
    Department of Chemistry and Biochemistry, The University of Texas, Austin, Texas 78712, USA
    J Am Chem Soc 135:10886-9. 2013
    ..The successful synthesis of citrinadin A led to a revision of the stereochemical structure of the core substructure of the citrinadins. ..
  53. ncbi Antiplasmodial activity of aspidosperma indole alkaloids
    A C Mitaine-Offer
    Laboratoire de Pharmacognosie, Faculte de Pharmacie, Universite de Reims Champagne Ardenne, France
    Phytomedicine 9:142-5. 2002
    ..Isobolograms were obtained and demonstrated a synergic effect of N-formyl-aspidospermidine and aspidospermine when associated with chloroquine. The cytotoxicity and the selectivity index of some alkaloids were also estimated...
  54. pmc Synthetic approaches to the bicyclo[2.2.2]diazaoctane ring system common to the paraherquamides, stephacidins and related prenylated indole alkaloids
    Kenneth A Miller
    Department of Chemistry, Colorado State University, Fort Collins, CO 80523 1872, USA
    Chem Soc Rev 38:3160-74. 2009
    ..Detailed herein are a number of synthetic disconnections including intramolecular S(N)2' cyclizations, biomimetic Diels-Alder reactions, radical cyclizations, and cationic cascade reactions...
  55. pmc Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism
    Kristina M Cook
    NCI, National Institutes of Health, Bethesda, Maryland 20814, USA
    J Biol Chem 284:26831-8. 2009
    ..The results have implications for the design of selective ETPs and for the interaction of ETPs with other zinc ion-binding protein targets involved in gene expression...
  56. ncbi Gastroprotective mechanisms of indole alkaloids from Himatanthus lancifolius
    Cristiane Hatsuko Baggio
    Department of Pharmacology, Biological Sciences Sector, Universidade Federal of Paraná, Curitiba, Brazil
    Planta Med 71:733-8. 2005
    The indole alkaloids mixture (AlkF) obtained from the barks of Himatanthus lancifolius (Muell. Arg.) Woodson was evaluated for gastroprotective properties in rodents...
  57. ncbi Induction of apoptosis in HuH-7 cancer cells by monoterpene and beta-carboline indole alkaloids isolated from the leaves of Tabernaemontana elegans
    Tayyab A Mansoor
    iMed UL, Faculdade de Farmacia, Universidade de Lisboa, Av D Forças Armadas, 1600 083 Lisboa, Portugal
    Bioorg Med Chem Lett 19:4255-8. 2009
    Three known (1-3) and a novel (4) monoterpene indole alkaloids have been isolated from the methanol extract of leaves of Tabernaemontana elegans and their structures were elucidated by a series of spectroscopic experiments, involving NMR, ..
  58. ncbi Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands
    Hiromitsu Takayama
    Laboratory of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi cho, 1 33, Inage Ku, Chiba 263 8522, Japan
    J Med Chem 45:1949-56. 2002
    ..The essential structural moieties in the Corynanthe type indole alkaloids for inducing the opioid agonistic activity were also clarified. The oxidative derivatives of mitragynine, i.e...
  59. ncbi Indole alkaloids and quassinoids from the stems of Brucea mollis
    Hui Chen
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    J Nat Prod 74:2438-45. 2011
    Seven new indole alkaloids, bruceollines H-N (1-7), three new quassinoids, yadanziolides T-V (10-12), and four known analogues, bruceolline E (8), bruceolline F (9), bruceine D (13), and yadanziolide B (14), were isolated from an ethanol ..
  60. ncbi Antimicrobial activities of indole alkaloids from Tabernaemontana catharinensis
    Maria Rita Furquini Medeiros
    Unidade de Biotecnologia, Universidade de Ribeirao Preto, SP, Brasil
    Nat Prod Commun 6:193-6. 2011
    ..coli and P. aeruginosa the MIC of MMV ranged from 0.08 to 0.31 mg/mL. The chromatography analysis of the EB2 fraction revealed the presence of indole alkaloids, including MMV, possibly responsible for the observed antimicrobial activity.
  61. ncbi Discovery of the development candidate N-tert-butyl nodulisporamide: a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals
    Peter T Meinke
    Merck Research Laboratories, Rahway, NJ 07065 0900, USA
    J Med Chem 52:3505-15. 2009
    ..Tissue distribution studies in mice using [(14)C]-labeled 3 indicate that adipose beds serve as ligand depots, contributing to the long terminal half-lives of these compounds...
  62. ncbi Rigorous biogenetic network for a group of indole alkaloids derived from strictosidine
    László F Szabó
    Department of Organic Chemistry, Semmelweis University, Hogyes utca 7, H 1092 Budapest, Hungary
    Molecules 13:1875-96. 2008
    Strictosidine, the precursor of more than 2,500 indole alkaloids, was isolated from four species of three plant families...
  63. ncbi Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua
    Hua Zhang
    State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi Tech Park, Shanghai 201203, People s Republic of China
    J Nat Prod 70:54-9. 2007
    Six new indole alkaloids, 14,15-didehydro-10,11-dimethoxy-16-epivincamine (1), 14,15-didehydro-10-hydroxy-11-methoxy-16-epivincamine (2), 14,15-didehydro-10,11-dimethoxyvincamine (3), 14,15-didehydro-10-hydroxy-11-methoxyvincamine (4), 19,..
  64. ncbi Naucleamides A-E, new monoterpene indole alkaloids from Nauclea latifolia
    Hideyuki Shigemori
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Chem Pharm Bull (Tokyo) 51:58-61. 2003
    Five new monoterpene indole alkaloids, naucleamides A-E (1-5), were isolated from the bark and wood of Nauclea latifolia, and the structures and relative stereochemistry were elucidated from the spectroscopic data...
  65. ncbi New cytotoxic indole alkaloids from Tabernaemontana calcarea from the Madagascar rainforest
    V S Prakash Chaturvedula
    Department of Chemistry, M C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Nat Prod 66:528-31. 2003
    ..of a CH(2)Cl(2)-MeOH extract of Tabernaemontana calcarea resulted in the isolation of the three new cytotoxic indole alkaloids, 1-3, and the 12 known alkaloids voacangine (4), isovoacangine (5), coronaridine (6), 11-hydroxycoronaridine (..
  66. ncbi Turbinatine, a potential key intermediate in the biosynthesis of corynanthean-type indole alkaloids
    Carmen Lucia Cardoso
    Instituto de Quimica, Universidade Estadual Paulista, UNESP, CP 355, CEP 14 801 970, Araraquara, Sao Paulo, Brazil
    J Nat Prod 66:1017-21. 2003
    ..has led to the isolation of turbinatine (1), a new corynanthean-type indole alkaloid, besides four known indole alkaloids, strictosidine, 5alpha-carboxystrictosidine, vallesiachotamine, and isovallesiachotamine...
  67. pmc Enhanced transdermal delivery of evodiamine and rutaecarpine using microemulsion
    Yong Tai Zhang
    School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People s Republic of China
    Int J Nanomedicine 6:2469-82. 2011
    ..The purpose of this study was to improve skin permeation of evodiamine and rutaecarpine for transdermal delivery with microemulsion as vehicle and investigate real-time cutaneous absorption of the drugs via in vivo microdialysis...
  68. ncbi Indole alkaloids from the leaves of Philippine Alstonia scholaris
    Allan Patrick G Macabeo
    Phytochemistry Laboratory, Research Center for the Natural Sciences, Thomas Aquinas Research Complex, University of Santo Tomas, Espana St, Manila 1008, Philippines
    Phytochemistry 66:1158-62. 2005
    ..isolated from the (pH 5) alkaloid extract of Philippine Alstonia scholaris leaves together with the known indole alkaloids 19,20-(E)-vallesamine (3), angustilobine B N4-oxide (4), 20(S)-tubotaiwine (5), and 6,7-seco-angustilobine B (..
  69. ncbi New indole alkaloids from the bark of Alstonia scholaris
    Angela A Salim
    Institute for Molecular Bioscience and Department of Chemistry, The University of Queensland, Brisbane, QLD 4072, Australia
    J Nat Prod 67:1591-4. 2004
    ..The structures of all compounds were elucidated by spectroscopic methods. This is the first report of compounds 3-5and 7 in A. scholaris. Some NMR assignments of the known compounds were revised...
  70. ncbi Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
    Andrew L Kung
    Dana Farber Cancer Institute and Harvard Medical School, Massachusetts 02115, USA
    Cancer Cell 6:33-43. 2004
    ....
  71. ncbi Tremorgenic mycotoxins increase gastric smooth muscle activity of sheep reticulum and rumen in vitro
    L Wang
    Department of Biological Sciences, The University of Waikato, PB 3105, Hamilton, New Zealand
    Res Vet Sci 74:93-100. 2003
    ..The results show that these mycotoxins have peripheral excitatory effects on the reticulorumen and it is suggested that such activity in vivo may reflexly affect centrally derived cyclical contractions...
  72. ncbi Simple indole alkaloids and those with a nonrearranged monoterpenoid unit
    Satoshi Hibino
    Faculty of Pharmacy and Pharmaceutical Science, Fukuyama University, Hiroshima, Japan
    Nat Prod Rep 19:148-80. 2002
    This review covers simple indole alkaloids, isoprenoid tryptamines, and bisindole alkaloids with a nonrearranged monoterpenoid unit...
  73. ncbi Biologically active indole alkaloids from Kopsia arborea
    Kuan Hon Lim
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 70:1302-7. 2007
    Nine new indole alkaloids, rhazinoline (1), 19(S)-methoxytubotaiwine (2), 19(R)-methoxytubotaiwine (3), kopsamidine A (4), kopsamidine B (5), kopsinidine A (6), kopsinidine B (7), paucidactine C (8), and pericine N-oxide (9), in addition ..
  74. pmc Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle
    Peter Bernhardt
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Chem Biol 14:888-97. 2007
    Monoterpene indole alkaloids from Catharanthus roseus (Madagascar periwinkle), such as the anticancer agents vinblastine and vincristine, have important pharmacological activities...
  75. ncbi K252a, an inhibitor of Trk, disturbs pathfinding of hippocampal mossy fibers
    Makoto Tamura
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Neuroreport 17:481-6. 2006
    ..Similar defasciculation was observed with an inhibitor of MEK, which is one of the signaling molecules downstream of Trk. This study suggests for the first time that Trk and the MEK pathway are required for mossy fiber pathfinding...
  76. pmc Halogenated indole alkaloids from marine invertebrates
    Patrícia Mendonça Pauletti
    Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca Av Dr Armando Salles de Oliveira, 201, CEP 14404 600, Franca, Sao Paulo, Brazil
    Mar Drugs 8:1526-49. 2010
    This review discusses the isolation, structural elucidation, and biological activities of halogenated indole alkaloids obtained from marine invertebrates...
  77. ncbi Structure-based engineering of strictosidine synthase: auxiliary for alkaloid libraries
    Elke A Loris
    Department of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg University Mainz, Staudingerweg 5, D 55099 Mainz, Germany
    Chem Biol 14:979-85. 2007
    ..condensation between tryptamine and secologanin, leading to the synthesis of about 2000 monoterpenoid indole alkaloids in higher plants...
  78. ncbi Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms
    Yong Hwan Choi
    College of Pharmacy, Kangwon National University, Chunchon, Korea
    Arch Pharm Res 29:293-7. 2006
    ..These pharmacological properties may provide the additional scientific rationale for anti-inflammatory use of the fruits of E. rutaecarpa...
  79. ncbi The fungal neurotoxin lolitrem B inhibits the function of human large conductance calcium-activated potassium channels
    Julie E Dalziel
    AgResearch Limited, Biomembrane Group, Grasslands Research Centre, Tennent Drive, Private Bag 11008, Palmerston North 5301, New Zealand
    Toxicol Lett 155:421-6. 2005
    ..This is the first time that a molecular site of action has been identified for a compound of the lolitrem structural class of indole diterpene and identifies a novel BK channel blocker...
  80. pmc Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells
    Adrian Staab
    Department of Radiation Oncology, University of Wurzburg, 97080 Wurzburg, Germany
    BMC Cancer 7:213. 2007
    ..We investigated whether targeting of HIF-1 using chetomin, a disrupter of the interaction of HIF-1 with the transcriptional coactivator p300, influences the radiosensitivity of hypoxic HT 1080 human fibrosarcoma cells...
  81. pmc K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses
    S H Nye
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    Mol Biol Cell 3:677-86. 1992
    ..A potential therapeutic application for these inhibitors is discussed...
  82. ncbi Secondary metabolites from three Florida sponges with antidepressant activity
    Anna J Kochanowska
    Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 71:186-9. 2008
    Brominated indole alkaloids are a common class of metabolites reported from sponges of the order Verongida...
  83. ncbi The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channels
    Wendy L Imlach
    AgResearch, Grasslands Research Centre, Palmerston North, New Zealand
    J Pharmacol Exp Ther 327:657-64. 2008
    ..Our study therefore reveals a new role for the accessory BK beta4 subunit in motor control. The beta4 subunit could be considered as a potential target for treatment of ataxic conditions in animals and in humans...
  84. ncbi Isolation of putative biosynthetic intermediates of prenylated indole alkaloids from a thermophilic fungus Talaromyces thermophilus
    Yan Sheng Chu
    Laboratory for Conservation and Utilization of Bio Resources, Yunnan University, Kunming 650091, PR China
    Org Lett 12:4356-9. 2010
    The putative key biosynthetic intermediates of prenylated indole alkaloids have long been proposed but never isolated...
  85. ncbi Simple indole alkaloids and those with a nonrearranged monoterpenoid unit
    Kazuhiro Higuchi
    Meiji Pharmaceutical University, 2 522 1 Kiyose, Tokyo 204 8588, Japan
    Nat Prod Rep 24:843-68. 2007
    This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit. Newly isolated alkaloids, structure determinations, total syntheses and biological activities are included.
  86. ncbi Structural determinants of lolitrems for inhibition of BK large conductance Ca2+-activated K+ channels
    Wendy L Imlach
    AgResearch, Grasslands Research Centre, Palmerston North 4442, New Zealand
    Eur J Pharmacol 605:36-45. 2009
    ..This study has identified seven new BK channel inhibitors and has allowed the identification of two key structural features required for high potency BK channel activity by lolitrems...
  87. ncbi New indole alkaloids from the North Sea bacterium Vibrio parahaemolyticus Bio249
    Ravikanth Veluri
    Department of Organic Chemistry, University of Gottingen, Tammannstrasse 2, D 37077 Gottingen, Germany
    J Nat Prod 66:1520-3. 2003
    ..Their structures were established on the basis of various spectral data, and their origin is discussed. All compounds were inactive against a range of bacteria and fungi...
  88. pmc Metabolic reprogramming of periwinkle plant culture
    Weerawat Runguphan
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue 18 592, Cambridge, Massachusetts 02139, USA
    Nat Chem Biol 5:151-3. 2009
    ..This work demonstrates the power of genetic engineering to retailor the structures of complex alkaloid natural products in plant culture...
  89. ncbi Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine
    Daniel B Yarosh
    AGI Dermatics, 205 Buffalo Avenue, Freeport, NY 11520, USA
    J Dermatol Sci 42:13-21. 2006
    ..Methyl nicotinate (MN) is known to induce the release of PGD(2) resulting in localized erythema within 30 min after topical application to human skin...
  90. ncbi Quality evaluation of Evodia rutaecarpa (Juss.) Benth by high performance liquid chromatography with photodiode-array detection
    Yang Zhao
    West China School of Pharmacy, Sichuan University, Chengdu 610041, China
    J Pharm Biomed Anal 48:1230-6. 2008
    ..The total contents of evodiamine and rutaecarpine in different samples were calculated and the blending method proposed was demonstrated to be very useful in saving resources and in guiding rational herb use...
  91. ncbi Leptoclinidamines A-C, indole alkaloids from the Australian ascidian Leptoclinides durus
    Anthony R Carroll
    Australian Rivers Institute, Griffith University, Gold Coast, Queensland, Australia
    J Nat Prod 72:696-9. 2009
    Three new indole alkaloids, leptoclinidamines A-C (1-3), were isolated from the Australian ascidian Leptoclinides durus. Their structures were determined by analysis of 2D NMR spectra...
  92. ncbi Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derive
    Vincent Burlat
    EA 2106, Plant Biocompounds and Biotechnology, UFR des Sciences et Techniques, Universite de Tours, 37200 Tours, France
    Plant J 38:131-41. 2004
    ..Many secondary metabolites, such as monoterpene indole alkaloids (MIAs) in Catharanthus roseus, are also synthesised from this source of IPP...
  93. ncbi Heterologous expression of a Rauvolfia cDNA encoding strictosidine glucosidase, a biosynthetic key to over 2000 monoterpenoid indole alkaloids
    Irina Gerasimenko
    Lehrstuhl fur Pharmazeutische Biologie, Institut fur Pharmazie, Johannes Gutenberg Universitat Mainz, Germany
    Eur J Biochem 269:2204-13. 2002
    ..SG) is an enzyme that catalyses the second step in the biosynthesis of various classes of monoterpenoid indole alkaloids. Based on the comparison of cDNA sequences of SG from Catharanthus roseus and raucaffricine glucosidase (RG) ..
  94. ncbi New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea
    Jin Feng Hu
    Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 65:476-80. 2002
    In addition to the sesquiterpene-phenol aureols (1), 6'-chloroaureol (2), and aureol acetate (3), eight indole alkaloids including the new N-3'-ethylaplysinopsin (9) have been isolated from the Jamaican sponge Smenospongia aurea...
  95. ncbi Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells
    Mariko Kitajima
    Department of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    J Nat Prod 69:715-8. 2006
    Four new gelsedine-type indole alkaloids (1-4) were isolated from the leaves of Gelsemium elegans, together with 11 known alkaloids...
  96. ncbi Total synthesis and antiproliferative activity screening of (+/-)-aplicyanins A, B and E and related analogues
    Miroslav Sisa
    Institute for Research in Biomedicine, Barcelona Science Park University of Barcelona, Baldiri Reixac 10, E 08028 Barcelona, Spain
    J Med Chem 52:6217-23. 2009
    The first total synthesis of the indole alkaloids (+/-)-aplicyanins A, B, and E, plus 17 analogues, all in racemic form, is reported...
  97. ncbi Symmetry C18 column: a better choice for the analysis of indole alkaloids of Catharanthus roseus
    G C Uniyal
    Central Institute of Medicinal and Aromatic Plants CIMAP, PO CIMAP, Lucknow 226015, India
    Phytochem Anal 12:206-10. 2001
    ..Detection was performed at 220 nm which presented better absorptivity for these indole alkaloids giving a minimum detection limit of 0.5 microgram...
  98. ncbi Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa
    Hiromitsu Takayama
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Chem Pharm Bull (Tokyo) 52:916-28. 2004
    ..growing in Thailand and Malaysia have led to the isolation of several 9-methoxy-Corynanthe-type monoterpenoid indole alkaloids, including new natural products...
  99. ncbi 1,2-bis(1H-indol-3-yl)ethane-1,2-dione, an indole alkaloid from the marine sponge Smenospongia sp
    Matthew J McKay
    AstraZeneca R and D, Griffith University, Brisbane, Australia
    J Nat Prod 65:595-7. 2002
    ....
  100. ncbi Bis and tris indole alkaloids from marine organisms: new leads for drug discovery
    Leena Gupta
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India
    Curr Med Chem 14:1789-803. 2007
    ....
  101. ncbi Role of brain-derived neurotrophic factor in the circadian regulation of the suprachiasmatic pacemaker by light
    F Q Liang
    Texas A and M University Health Science Center, Department of Human Anatomy, College of Medicine, College Station, Texas 77843 1114, USA
    J Neurosci 20:2978-87. 2000
    ..Collectively, these findings suggest that BDNF-mediated signaling may play an important role in the circadian regulation of SCN pacemaker sensitivity to light...

Research Grants62

  1. NOVEL PALLADIUM CATALYZED SYNTHESES OF INDOLE ALKALOIDS
    BJORN SODERBERG; Fiscal Year: 2001
    ..of this proposal is to develop short, mild, general, and versatile synthetic routes to polyfunctionalized indole alkaloids. The key step in this methodology is a recently developed, palladium catalyzed, N-heteroannulation reaction ..
  2. TOTAL SYNTHESIS AND BIOSYNTHESIS OF BIOACTIVE SUBSTANCES
    Robert Michael Williams; Fiscal Year: 2013
    ..amino acids (isoleucine, proline, and tryptophan) and mevalonate-derived isoprene moieties to the polycyclic indole alkaloids comprising the paraherquamides, stephacidins, avrainvillamide, notoamides, norgeamides, malbrancheamides and ..
  3. Phosphine-Catalyzed Annulations and Their Applications
    Ohyun Kwon; Fiscal Year: 2010
    ..with aldimines to form tetrahydropyridines could be geared to the chemical synthesis of indole alkaloids, such as hirsuteine, hirsutine, alstonerine, macroline, alstomicine, and reserpine...
  4. Enantioselective Total Synthesis of Marcfortine B via SmI2-mediated C-C Bond Form
    TIMOTHY KUM BENG; Fiscal Year: 2013
    ..reactions between our proposed dienophile and 1,1-disubstituted dienes in the synthesis of prenylated indole alkaloids. Our proposed plan will mark the first enantioselective synthesis of any member of the marcfortine family...
  5. STEREOCONTROLLED SYNTHESIS OF BIOACTIVE ALKALOIDS
    VIRESH RAWAL; Fiscal Year: 2007
    ..Overall, these investigations are expected to result not only in efficient syntheses of a wide range of indole alkaloids, but also in the development of useful new methodologies, particularly palladium-catalyzed processes and ..
  6. Organocascade catalysis - total synthesis of Ochrosamine B
    Eduardas Skucas; Fiscal Year: 2012
    ..The B|chi-type ketone 2 is a common structural motif of Aspidosperma and Strychnos family indole alkaloids, such as tubifoline, vindoline and ochrosamine B, which exhibit biological properties across a broad spectrum ..
  7. Canthinones as Human Isozyme Selective PDE4 Inhibitors
    KEVIN CZERWINSKI; Fiscal Year: 2002
    ..research is to investigate the inhibitory activity of substituted canthin-6-one and canthin-5, 6-dione indole alkaloids against human cAMP phosphodiesterase (PDE4) isoenzymes...
  8. GENETICS OF SUSCEPTIBILITY TO SKIN TUMOR PROMOTION
    John DiGiovanni; Fiscal Year: 1990
    ..mice (and possibly other inbred strains) to different classes of skin tumor promoting agents including indole alkaloids, polyacetates, anthrones, and organic peroxides...
  9. Synthesis and Study of Complex Natural Products
    Mohammad Movassaghi; Fiscal Year: 2013
    ..development of highly chemo- and stereoselective transformations relevant to assembly of more complex terpene-indole alkaloids. This program will result in a vast number of synthetic samples of rare and precious molecules...
  10. Methodology for Alkaloid Total Synthesis
    STEVEN WEINREB; Fiscal Year: 2009
    ..to vinylnitroso compounds will constitute key steps in total syntheses of the vallesamine class of indole alkaloids including (Z)-vallesamine, angustilobine A and angustilodine...
  11. STEREOCONTROLLED SYNTHESIS OF BIOACTIVE ALKALOIDS
    VIRESH RAWAL; Fiscal Year: 2000
    ..Overall, these investigations are expected to result in not only efficient syntheses of a wide range of indole alkaloids, but also to the development of methodology, particularly palladium catalyzed processes, that should prove ..
  12. TOTAL SYNTHESES OF INDOLE ALKALOIDS
    MARTIN KUEHNE; Fiscal Year: 2002
    This proposal is a continuation of our synthetic efforts in indole alkaloids that have significant pharmacological activity for clinical use...
  13. ANALOGS OF ANTINEOPLASTIC INDOLE ALKALOIDS
    RICHARD SUNDBERG; Fiscal Year: 1991
    The purpose of this projects is to synthesize and characterize new analogs at the antineoplastic dimeric indole alkaloids of the vincristine- vinblastine type...
  14. SYNTHESIS OF ANTHRACYCLINONES
    WILLIAM WULFF; Fiscal Year: 1993
    ..is proposed that they be investigated with regard to the synthesis of several members of the aspidospermia alkaloid family including vindoline which is a constituent of the dimeric antitumor indole alkaloids vinblastine and vincristine.
  15. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..Synthetic approaches to isodomoic acid H, hepatitis C viral inihibiting indole alkaloids, the salicylihalimide macrolactone oximidine II, and polyene antiviral antibiotic viridenomycin are detailed...
  16. METHODOLOGY FOR THE SYNTHESIS OF NITROGEN HETEROCYCLES
    Philip Magnus; Fiscal Year: 2007
    ..Also it is intended to investigate the synthesis of the marine indole alkaloids, securine A/B, securamine A/B and chartelline A using a putative biomimetic strategy...
  17. SYNTHESIS OF MEDICINALLY INTERESTING MOLECULES
    Ronald Parry; Fiscal Year: 1999
    ..5) Development of an efficient synthetic protocol for indole alkaloids including tabersonine and catharanthine...
  18. BIOMEDICAL RESEARCH SUPPORT
    Seymour Lieberman; Fiscal Year: 1991
    ..Development of New Synthetic Methods and Total Synthesis of Natural Products (Snider); Short Synthesis of Indole Alkaloids (Hendrickson)...
  19. Tandem Cycloadditions for Alkaloids Synthesis
    JENNIFER SCHAUS; Fiscal Year: 2003
    This application describes the development of sequential cycloadditions for the stereocontrolled synthesis of indole alkaloids framework and its application toward the synthesis of a new indole alkaloid--3-demethoxymyrtoidine...
  20. Total Synthesis of Anti-Cancer Natural Products
    Phil S Baran; Fiscal Year: 2010
    ..New strategies and methods in chemistry and substantial contributions to medicine are anticipated through strategic collaborations with several leaders in the field of cancer biology. ..
  21. Oxidative Coupling in Natural Product Synthesis
    Phil Baran; Fiscal Year: 2009
    ....
  22. Alkynyliodonium Salts and Derived Diyls in Synthesis
    Ken Feldman; Fiscal Year: 2009
    ..abstract_text> ..
  23. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  24. Chemical and Biological Studies on Biaryl Phenolics
    Ken Feldman; Fiscal Year: 2005
    ..The search for selective 20S proteosome inhibitors among the Ntn-type proteases will be advanced by these investigations. ..
  25. New Methodology for Indole Alkaloid Syntheses
    Ken S Feldman; Fiscal Year: 2010
    ..The use of a new variant of the Pummerer reaction to control both oxidation level and reaction site within the indole nucleus forms the basis of this chemistry. ..
  26. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
    ..In the course of these investigations, new molecular reactivity will be developed that will substantially shorten current routes to polycyclic natural products and drug candidates. ..
  27. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  28. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  29. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  30. HETEROCYCLIC RING COMPOUNDS FOR ALKALOID SYNTHESIS
    Albert Padwa; Fiscal Year: 2007
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  31. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  32. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  33. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  34. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  35. NEUROTROPHIN CONTROL OF REM SLEEP
    Jack Yamuy; Fiscal Year: 2004
    ..This concerted set of experiments will be critical in elucidating the role that neurotrophins play in the control of REM sleep. ..
  36. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  37. SYNTHESIS OF FUSED HETEROCYCLIC COMPOUNDS
    Albert Padwa; Fiscal Year: 2002
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  38. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  39. Molecular Approaches to Understanding Global Regulation in Paclitaxel Accumulatio
    Elsbeth L Walker; Fiscal Year: 2010
    ..Because production of paclitaxel in the U.S. and world depends on plant cell culture technology, this research will directly impact future paclitaxel supply for both current and emerging applications. ..
  40. An in situ Neuronal Model of PHF-TAU Accumulation in AD
    Garth Hall; Fiscal Year: 2004
    ..abstract_text> ..
  41. Biosynthesis of Hypotensive Phosphonopeptide Natural Products
    Brian O Bachmann; Fiscal Year: 2010
    ..Metalloproteinase inhibitors have potential to treat a large number of human illnesses including hypertension, cancer and osteoarthritis, among others. ..
  42. BEHAVIORALLY INDUCED NEUROCHEMICAL PLASTICITY
    Christine Gall; Fiscal Year: 2001
    ..The proposed work will provide a first test for their presence in regions engaged learning behaviors. ..
  43. THE SYNTHESIS OF LACTONAMYCIN AND ANALOGS
    T Kelly; Fiscal Year: 2003
    ..To test, in collaboration with Pfizer Inc., analogs and synthetic intermediates for antibiotic, anticancer and other biological activities. ..
  44. APPROACHES TO CHARACTERIZATION OF ANTIINFECTIVE AGENTS
    Mark Hamann; Fiscal Year: 2002
    ..SAR studies will be conducted utilizing chemical and microbial transformations of biologically active secondary metabolites combined with molecular modeling studies. ..
  45. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
    ....
  46. A Molecular Motor
    T Kelly; Fiscal Year: 2004
    ..The project should expand the understanding of chemically directed and controlled movement, which is a topic central to the understanding of biological systems. ..
  47. Purification of Optically Labeled Oligonucleotides
    William Pearson; Fiscal Year: 2004
    ..Initial work will focus on oligonucleotide probe purification. ..
  48. SYNTHESIS OF CYTOTOXIC GUAIANOLIDES AND OTHER TERPENOIDS
    JAMES RIGBY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  49. Cigarette Smoke in Early Life Alters Airway Reactivity
    Zhong Xin Wu; Fiscal Year: 2007
    ..The findings will provide new understanding about the mechanisms of ETS susceptibility during early life. [unreadable] [unreadable] [unreadable]..
  50. INTEGRIN REGULATION AND FUNCTIONS IN ADULT BRAIN
    Christine Gall; Fiscal Year: 2007
    ..As a consequence these findings are important for understanding basic mechanisms of neuronal communication and survival in the adult CNS. ..
  51. Action of Novel Anti-tumor Agents on Cell Communication
    Diane Matesic; Fiscal Year: 2005
    ..abstract_text> ..
  52. Purification of Oligonucleotides and Nucleoside Triphosphates
    William Pearson; Fiscal Year: 2007
    ..The proposed work seeks to further develop an entirely new method for oligonucleotide purification, thus streamlining the development and production of these crucial substances. [unreadable] [unreadable] [unreadable]..
  53. SYNTHESIS OF COCARCINOGENIC DITERPENES
    JAMES RIGBY; Fiscal Year: 2005
    ..These projected investigations should generate substantial new knowledge about complex synthesis as well as providing additional insight into some of the bioactivity exhibited by the subject natural products. ..
  54. Intramolecular Aryne Cycloadditions and Rearrangements
    KEITH BUSZEK; Fiscal Year: 2008
    ..abstract_text> ..
  55. Biochemical Analysis and Engineering of Lovastatin Polyketide Synthase
    Yi Tang; Fiscal Year: 2008
    ..Reconstitute fungal polyketide biosynthesis in a heterologous host. Aim 2. Mechanistic analysis of fungal PKS enzymes. Aim 3. Structural analysis of fungal PKS domains. [unreadable] [unreadable] [unreadable]..
  56. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  57. SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS
    BARRY SNIDER; Fiscal Year: 2009
    ..In the course of these studies new methods will be developed that are of general utility for preparing drugs more economically. ..
  58. Development of a Novel Anti-Neuroinflammatory AD Therapeutic
    D Watterson; Fiscal Year: 2008
    ..This U01 project has highly feasible annual milestones, with the final one being development of a synthetic protocol compatible with GMP synthesis by an FDA compliant contract research organization. ..
  59. RAPID KINETIC AND OTHER STUDIES OF BIOLOGICAL OXYGENASES
    David Ballou; Fiscal Year: 2009
    ..This may, in turn, lead to an improved ability to predict and deal with the metabolism of various compounds in the environment. ..