riboflavin

Summary

Summary: Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.

Top Publications

  1. ncbi Riboflavin (vitamin B-2) and health
    Hilary J Powers
    Centre for Human Nutrition, The University of Sheffield, United Kingdom
    Am J Clin Nutr 77:1352-60. 2003
  2. ncbi Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Germany
    Am J Ophthalmol 135:620-7. 2003
  3. ncbi Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Dresden, Germany
    J Cataract Refract Surg 29:1780-5. 2003
  4. ncbi Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results
    Frederik Raiskup-Wolf
    Department of Ophthalmology, C G Carus University Hospital, Dresden, Germany
    J Cataract Refract Surg 34:796-801. 2008
  5. ncbi Safety of UVA-riboflavin cross-linking of the cornea
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum Dresden, Dresden, Germany
    Cornea 26:385-9. 2007
  6. ncbi Increased resistance of crosslinked cornea against enzymatic digestion
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum CGC, Fetscherstrasse 74, D 01307 Dresden, Germany
    Curr Eye Res 29:35-40. 2004
  7. ncbi The chemical and biological versatility of riboflavin
    V Massey
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 0606, USA
    Biochem Soc Trans 28:283-96. 2000
  8. ncbi Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study
    Aldo Caporossi
    Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    Am J Ophthalmol 149:585-93. 2010
  9. ncbi Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study
    Aldo Caporossi
    Department of Ophthalmological and Neurosurgical Sciences, Siena University, Siena, Italy
    J Cataract Refract Surg 32:837-45. 2006
  10. ncbi Corneal collagen cross-linking using riboflavin and ultraviolet-A irradiation: a review of clinical and experimental studies
    Maria Gkika
    Eye Institute of Thrace and Department of Ophthalmology, Medical School of Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece
    Int Ophthalmol 31:309-19. 2011

Detail Information

Publications365 found, 100 shown here

  1. ncbi Riboflavin (vitamin B-2) and health
    Hilary J Powers
    Centre for Human Nutrition, The University of Sheffield, United Kingdom
    Am J Clin Nutr 77:1352-60. 2003
    b>Riboflavin is unique among the water-soluble vitamins in that milk and dairy products make the greatest contribution to its intake in Western diets...
  2. ncbi Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Germany
    Am J Ophthalmol 135:620-7. 2003
    ..a significant increase in corneal biomechanical stiffness has been found after collagen crosslinking by combined riboflavin/ultraviolet-A (UVA) treatment...
  3. ncbi Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Dresden, Germany
    J Cataract Refract Surg 29:1780-5. 2003
    To evaluate the biomechanical effect of combined riboflavin-ultraviolet A (UVA) treatment on porcine and human corneas.
  4. ncbi Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results
    Frederik Raiskup-Wolf
    Department of Ophthalmology, C G Carus University Hospital, Dresden, Germany
    J Cataract Refract Surg 34:796-801. 2008
    To prove the long-term dampening effect of riboflavin- and ultraviolet-A-induced collagen crosslinking on progressive keratoconus.
  5. ncbi Safety of UVA-riboflavin cross-linking of the cornea
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum Dresden, Dresden, Germany
    Cornea 26:385-9. 2007
    To study potential damage to ocular tissue during corneal collagen cross-linking (X-linking) by means of the riboflavin/UVA (370 nm) approach.
  6. ncbi Increased resistance of crosslinked cornea against enzymatic digestion
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum CGC, Fetscherstrasse 74, D 01307 Dresden, Germany
    Curr Eye Res 29:35-40. 2004
    Collagen-crosslinking using combined riboflavin/ UVA treatment has been developed by us as a new treatment for keratoconus by stiffening the collagenous matrix...
  7. ncbi The chemical and biological versatility of riboflavin
    V Massey
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 0606, USA
    Biochem Soc Trans 28:283-96. 2000
    ..One of the main thrusts of current research is to try to define the nature of these interactions, and to understand in chemical terms the various steps involved in catalysis by flavoprotein enzymes...
  8. ncbi Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study
    Aldo Caporossi
    Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    Am J Ophthalmol 149:585-93. 2010
    To report the long-term results of 44 keratoconic eyes treated by combined riboflavin ultraviolet A collagen cross-linking in the first Italian open, nonrandomized phase II clinical trial, the Siena Eye Cross Study.
  9. ncbi Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study
    Aldo Caporossi
    Department of Ophthalmological and Neurosurgical Sciences, Siena University, Siena, Italy
    J Cataract Refract Surg 32:837-45. 2006
    To assess the effectiveness of riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen in reducing progression of keratoconus and in improving visual acuity in patients with progressive keratoconus.
  10. ncbi Corneal collagen cross-linking using riboflavin and ultraviolet-A irradiation: a review of clinical and experimental studies
    Maria Gkika
    Eye Institute of Thrace and Department of Ophthalmology, Medical School of Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece
    Int Ophthalmol 31:309-19. 2011
    Corneal collagen cross-linking (CXL) using riboflavin and ultraviolet-A irradiation is a common method of tissue stabilization and has been developed primarily to address the need of treating keratoconus...
  11. ncbi Equivalence of biomechanical changes induced by rapid and standard corneal cross-linking, using riboflavin and ultraviolet radiation
    Silvia Schumacher
    IROC AG, Institute of Refractive and Ophthalmic Surgery, Stockerstrasse 37, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 52:9048-52. 2011
    ..The authors evaluated whether a rapid treatment protocol (higher intensity and shorter irradiation time) could achieve the same increase in corneal stiffness as the currently used standard protocol...
  12. ncbi Stability of simultaneous topography-guided photorefractive keratectomy and riboflavin/UVA cross-linking for progressive keratoconus: case reports
    Ronald R Krueger
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Refract Surg 26:S827-32. 2010
    ..To follow the stability of a simultaneously delivered therapy that corrects aberrations and stiffens the corneal collagen of eyes with progressive keratoconus...
  13. ncbi Flavogenomics--a genomic and structural view of flavin-dependent proteins
    Peter Macheroux
    Institute of Biochemistry, Graz University of Technology, Graz, Austria
    FEBS J 278:2625-34. 2011
    b>Riboflavin (vitamin B(2)) serves as the precursor for FMN and FAD in almost all organisms that utilize the redox-active isoalloxazine ring system as a coenzyme in enzymatic reactions...
  14. pmc PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release
    Ramandeep Singh
    Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Science 322:1392-5. 2008
    ..Furthermore, NO scavengers protected the bacilli from the lethal effects of the drug. Thus, these compounds may act as intracellular NO donors and could augment a killing mechanism intrinsic to the innate immune system...
  15. ncbi Keratocyte cytotoxicity of riboflavin/UVA-treatment in vitro
    G Wollensak
    Department of Ophthalmology, Technical University of Dresden, Dresden, Germany
    Eye (Lond) 18:718-22. 2004
    Collagen crosslinking using ultraviolet- A (UVA) -irradiation combined with the photosensitizer riboflavin is a new technique for treating progressive keratoconus...
  16. ncbi Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas
    Farhad Hafezi
    Institute for Refractive and Ophthalmic Surgery, Zurich, Switzerland
    J Cataract Refract Surg 35:621-4. 2009
    Corneal collagen crosslinking (CXL) with riboflavin and ultraviolet-A light is a method for treating progressive keratectasia...
  17. ncbi Photochemical kinetics of corneal cross-linking with riboflavin
    Pavel Kamaev
    Avedro, Waltham, Massachusetts 02451, USA
    Invest Ophthalmol Vis Sci 53:2360-7. 2012
    To model the photochemical kinetics of corneal cross-linking with riboflavin (Rf) and confirm the model through measured oxygen concentration experiments under varying energy input conditions by UV-A irradiance and temperature modulation ..
  18. pmc Riboflavin ameliorates cisplatin induced toxicities under photoillumination
    Iftekhar Hassan
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India
    PLoS ONE 7:e36273. 2012
    ..The severity of these side effects consequently restricts its clinical use under long term treatment. Riboflavin is an essential vitamin used in various metabolic redox reactions in the form of flavin adenine dinucleotide and ..
  19. pmc Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking
    Yuntao Zhang
    Division of Biology, Kansas State University, Manhattan, Kansas 66506 4901, USA
    J Biol Chem 286:13011-22. 2011
    Corneal cross-linking using riboflavin and ultraviolet-A (RFUVA) is a clinical treatment targeting the stroma in progressive keratoconus...
  20. ncbi Riboflavin-UVA-induced corneal collagen cross-linking in pediatric patients
    Aldo Caporossi
    Department of Ophthalmology, Siena University, Siena, Italy
    Cornea 31:227-31. 2012
    Evaluation of stability and functional response after riboflavin-UVA–induced cross-linking in a population of patients younger than 18 years with progressive keratoconus after 36 months of follow-up.
  21. ncbi A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results
    Christine Wittig-Silva
    Centre for Eye Research Australia, East Melbourne, Australia
    J Refract Surg 24:S720-5. 2008
    ..This prospective, randomized, controlled trial aims to provide evidence in relation to the efficacy and safety of corneal collagen cross-linking (CXL) in the management of progressive keratoconus...
  22. ncbi Effects of riboflavin/UVA corneal cross-linking on keratocytes and collagen fibres in human cornea
    Rita Mencucci
    Department of Oto Neuro Ophthalmological Surgical Sciences, Eye Clinic, Florence, Italy
    Clin Experiment Ophthalmol 38:49-56. 2010
    ..To evaluate the effects of corneal cross-linking on keratocytes and collagen fibres in human corneas...
  23. pmc Quantitative assessment of UVA-riboflavin corneal cross-linking using nonlinear optical microscopy
    Dongyul Chai
    The Gavin Herbert Eye Institute, University of California, Irvine, Irvine, California 92697, USA
    Invest Ophthalmol Vis Sci 52:4231-8. 2011
    Corneal collagen cross-linking (CXL) by the use of riboflavin and ultraviolet-A light (UVA) is a promising and novel treatment for keratoconus and other ectatic disorders...
  24. ncbi Ameliorative effect of riboflavin on the cisplatin induced nephrotoxicity and hepatotoxicity under photoillumination
    I Hassan
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, UP 202 002, India
    Food Chem Toxicol 48:2052-8. 2010
    ..b>Riboflavin (vitamin B(2)) is a strong photosensitizer because it generates reactive oxygen species (ROS) upon ..
  25. ncbi Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants
    Leslie I Grad
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Biochim Biophys Acta 1757:115-22. 2006
    ..The metabolic and reproductive fitness of the mutants is markedly improved by riboflavin. In this study, we have examined how the assembly and activity of complexes I and IV are affected by riboflavin...
  26. ncbi Update on clinical aspects and treatment of selected vitamin-responsive disorders II (riboflavin and CoQ 10)
    Rita Horvath
    Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    J Inherit Metab Dis 35:679-87. 2012
    b>Riboflavin and ubiquinone (Coenzyme Q(10), CoQ(10)) deficiencies are heterogeneous groups of autosomal recessive conditions affecting both children and adults...
  27. ncbi Transepithelial corneal collagen crosslinking: bilateral study
    Massimo Filippello
    Casa Di Cura Di Stefano Velona, Catania, Italy
    J Cataract Refract Surg 38:283-91. 2012
    ..To evaluate the efficacy of transepithelial collagen crosslinking (CXL) in patients with bilateral progressive keratoconus...
  28. ncbi Effect of corneal epithelium on ultraviolet-A and riboflavin absorption
    Kátia Mantovani Bottós
    Department of Ophthalmology, Universidade Federal de Sao Paulo, Brazil
    Arq Bras Oftalmol 74:348-51. 2011
    ..Using immunofluorescence microscopy after CXL, we indirectly analyzed the role of the epithelium as ultraviolet-A (UVA) shield as well as a barrier to riboflavin penetration.
  29. ncbi Corneal collagen cross-linking with riboflavin and ultraviolet-A irradiation in patients with thin corneas
    George D Kymionis
    Institute of Vision and Optics, University of Crete, Heraklion, Crete, Greece
    Am J Ophthalmol 153:24-8. 2012
    To report the outcomes after corneal collagen cross-linking (CXL) treatment with riboflavin and ultraviolet-A (UVA) irradiation in patients with thin corneas (minimum corneal thickness less than 400 μm after epithelial removal and before ..
  30. ncbi Crosslinking treatment of progressive keratoconus: new hope
    Gregor Wollensak
    Department of Ophthalmology, Universitatsklinikum CGC, Dresden, Germany
    Curr Opin Ophthalmol 17:356-60. 2006
    ..been introduced for the treatment of progressive keratoconus using collagen crosslinking by the photosensitzer riboflavin and ultraviolet A-light. Biomechanical measurements have shown an impressive increase in corneal rigidity of 328...
  31. ncbi Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts
    Hans Peter Iseli
    Institute of Refractive and Ophthalmic Surgery, Zurich, Switzerland
    Cornea 27:590-4. 2008
    ..To evaluate the efficacy of ultraviolet-corneal cross-linking (CXL) for treating infectious melting keratitis...
  32. ncbi Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans
    Cosimo Mazzotta
    Department of Ophthalmology and Neurosurgery, University of Siena, Siena, Italy
    Cornea 26:390-7. 2007
    To assess ultrastructural stromal modifications after riboflavin-UVA-induced cross-linking of corneal collagen in patients with progressive keratoconus.
  33. ncbi Collagen cross-linking in early keratoconus with riboflavin in a femtosecond laser-created pocket: initial clinical results
    Anastasios John Kanellopoulos
    Laservision gr Institute, Athens, Greece
    J Refract Surg 25:1034-7. 2009
    To evaluate the safety and efficacy of a novel femtosecond laser-assisted technique for intrastromal administration of riboflavin and higher fluence ultraviolet a (UVA) light in collagen cross-linking (CXL) for keratoconus.
  34. ncbi Riboflavin-induced priming for pathogen defense in Arabidopsis thaliana
    Shujian Zhang
    Plant Growth and Defense Signaling Laboratory, Group of Key Laboratory of Monitoring and Management of Plant Pathogens and Insect Pests, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China
    J Integr Plant Biol 51:167-74. 2009
    b>Riboflavin (vitamin B(2)) participates in a variety of redox processes that affect plant defense responses. Previously we have shown that riboflavin induces pathogen resistance in the absence of hypersensitive cell death (HCD) in plants...
  35. ncbi Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin/UVA
    Gregor Wollensak
    Department of Ophthalmology, Universitatsklinikum CGC, Dresden, Germany
    Cornea 23:503-7. 2004
    ..The aim of the present study was to evaluate the effect of this new procedure on the collagen fiber diameter of the rabbit cornea...
  36. ncbi Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy
    Sally Hayes
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cathays, Cardiff, Wales, United Kingdom
    J Cataract Refract Surg 34:657-61. 2008
    To evaluate the importance of complete epithelial removal before riboflavin-ultraviolet-A (UVA) corneal collagen crosslinking therapy.
  37. ncbi Biosynthesis of vitamin b2 (riboflavin)
    A Bacher
    Lehrstuhl fur Organische Chemie und Biochemie, Lichtenbergstr 4, D 85747 Garching, Federal Republic of Germany
    Annu Rev Nutr 20:153-67. 2000
    The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates...
  38. ncbi Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation
    Steinar Hustad
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
    Clin Chem 48:1571-7. 2002
    Vitamin B(2) exists in blood as riboflavin and its cofactors, flavin mononucleotide (FMN) and FAD. The erythrocyte glutathione reductase activation coefficient (EGRAC) has traditionally been used to assess vitamin B(2) status in humans...
  39. ncbi Evaluation of antibacterial efficacy of photo-activated riboflavin using ultraviolet light (UVA)
    Karim Makdoumi
    Department of Ophthalmology, Orebro University Hospital, Orebro, Sweden
    Graefes Arch Clin Exp Ophthalmol 248:207-12. 2010
    To evaluate the antibacterial efficacy of photo-activated riboflavin using Ultraviolet A (UVA) on three bacterial strains commonly detected in keratitis.
  40. ncbi Corneal thickness changes after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results
    Steven A Greenstein
    Cornea and Laser Eye Institute Hersh Vision Group, CLEI Center for Keratoconus, Teaneck, New Jersey 07666, USA
    J Cataract Refract Surg 37:691-700. 2011
    ..To determine the changes in corneal thickness over time after corneal collagen crosslinking (CXL) for keratoconus and corneal ectasia...
  41. ncbi Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus
    Paolo Vinciguerra
    Department of Ophthalmology, Istituto Clinico Humanitas, Via Manzoni 56, Rozzano 20089, Milan, Italy
    Arch Ophthalmol 127:1258-65. 2009
    ..To report intraoperative and 24-month refractive, topographic, tomographic, and aberrometric outcomes after corneal collagen cross-linking in progressive advanced keratoconus...
  42. ncbi Results of corneal collagen cross-linking in pediatric patients
    Ritu Arora
    Furu Nanak Eye Centre, New Delhi, India
    J Refract Surg 28:759-62. 2012
    ..To evaluate the safety and efficacy of corneal collagen cross-linking (CXL) in the treatment of keratoconus in pediatric patients...
  43. ncbi Collagen cross-linking (CCL) with sequential topography-guided PRK: a temporizing alternative for keratoconus to penetrating keratoplasty
    A John Kanellopoulos
    Laservision gr Institute, Athens, Greece
    Cornea 26:891-5. 2007
    ..To assess the effectiveness of ultraviolet A (UVA) irradiation-induced collagen cross-linking (CCL) on keratoconus (KC) progression...
  44. ncbi Complication and failure rates after corneal crosslinking
    Tobias Koller
    From Institut für Refraktive und Ophthalmo Chirurgie, Zurich, Switzerland
    J Cataract Refract Surg 35:1358-62. 2009
    ..To evaluate the complication rate of corneal crosslinking (CXL) for primary keratectasia and to develop recommendations for avoiding complications...
  45. ncbi Long-term biomechanical properties of rabbit cornea after photodynamic collagen crosslinking
    Gregor Wollensak
    Eye Laser Center, Department of Ophthalmology, Martin Luther University, Halle, Germany
    Acta Ophthalmol 87:48-51. 2009
    Photodynamic riboflavin/ultraviolet-A (UVA)-induced collagen cross-linking, which increases the biomechanical stiffness of the human cornea by about 300%, has been introduced recently as a possible treatment for progressive keratoconus...
  46. pmc Riboflavin biosynthesis is associated with assimilatory ferric reduction and iron acquisition by Campylobacter jejuni
    Rachel A Crossley
    Institute of Food Research, Office E410, Norwich Research Park, Colney Lane, Norwich NR4 7UA, United Kingdom
    Appl Environ Microbiol 73:7819-25. 2007
    ..In this study, the links among riboflavin biosynthesis, ferric reduction, and iron acquisition in C. jejuni NCTC11168 have been investigated...
  47. ncbi Riboflavin production by Ashbya gossypii
    Tatsuya Kato
    Department of Applied Biological Chemistry, Shizuoka University, 836 Ohya Suruga ku, Shizuoka, 422 8529, Japan
    Biotechnol Lett 34:611-8. 2012
    b>Riboflavin is an important nutrient for humans and animals. Industrial production has shifted completely from chemical synthesis to microbial fermentation...
  48. ncbi Clinical and corneal biomechanical changes after collagen cross-linking with riboflavin and UV irradiation in patients with progressive keratoconus: results after 2 years of follow-up
    Yakov Goldich
    Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel
    Cornea 31:609-14. 2012
    To assess the biomechanical and keratometric effects and the safety of treatment of progressive keratoconus with UV-riboflavin collagen cross-linking (CXL).
  49. ncbi Riboflavin osmolar modification for transepithelial corneal cross-linking
    Frederik Raiskup
    Department of Ophthalmology, Carl Gustav Carus University Hospital, Fetscherstrasse 74, Dresden, Germany
    Curr Eye Res 37:234-8. 2012
    To investigate the influence of osmolarity on the transepithelial permeability of riboflavin solutions in a cross-linking procedure.
  50. pmc Riboflavin/UVA collagen cross-linking-induced changes in normal and keratoconus corneal stroma
    Sally Hayes
    Structural Biophysics Research Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    PLoS ONE 6:e22405. 2011
    To determine the effect of Ultraviolet-A collagen cross-linking with hypo-osmolar and iso-osmolar riboflavin solutions on stromal collagen ultrastructure in normal and keratoconus ex vivo human corneas.
  51. ncbi Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light
    Markus Kohlhaas
    Department of Ophthalmology, Universitatsklinikum CGC, Dresden, Germany
    J Cataract Refract Surg 32:279-83. 2006
    ..To examine to which depth of the cornea the stiffening effect is biomechanically detectable...
  52. ncbi Modulation of central corneal thickness by various riboflavin eyedrop compositions in porcine corneas
    Jan M Vetter
    Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    J Cataract Refract Surg 38:525-32. 2012
    To evaluate the modulatory effect of various riboflavin 0.1% and 0.2% compositions on the central corneal thickness (CCT) in fresh porcine corneas.
  53. ncbi Combined transepithelial phototherapeutic keratectomy and corneal collagen cross-linking for progressive keratoconus
    George D Kymionis
    Institute of Vision and Optics IVO, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Ophthalmology 119:1777-84. 2012
    ....
  54. ncbi Corneal cross-linking with hypo-osmolar riboflavin solution in thin keratoconic corneas
    Frederik Raiskup
    Department of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, Germany
    Am J Ophthalmol 152:28-32.e1. 2011
    To evaluate the 1-year results of keratoconic eyes with thin corneas that were treated by a hypo-osmolar riboflavin solution and ultraviolet A collagen cross-linking (CXL).
  55. ncbi Accelerated corneal crosslinking concurrent with laser in situ keratomileusis
    H Ugur Celik
    Beyoglu Eye Training and Research Hospital, Istanbul, Turkey
    J Cataract Refract Surg 38:1424-31. 2012
    ..To assess accelerated corneal collagen crosslinking (CXL) applied concurrently with laser in situ keratomileusis (LASIK) in a small group of patients...
  56. ncbi Limitation of collagen cross-linking with hypoosmolar riboflavin solution: failure in an extremely thin cornea
    Farhad Hafezi
    Geneva University Hospitals, Geneva, Switzerland
    Cornea 30:917-9. 2011
    We report a case of failure of corneal collagen cross-linking (CXL) for progressive keratoconus after preoperative stromal swelling with hypoosmolar riboflavin solution in an extremely thin cornea.
  57. pmc The Brown-Vialetto-Van Laere and Fazio Londe syndrome revisited: natural history, genetics, treatment and future perspectives
    Annet M Bosch
    Department of Pediatrics, University of Amsterdam, Amsterdam, The Netherlands
    Orphanet J Rare Dis 7:83. 2012
    ..in some patients the disease is caused by mutations in the SLC52A3 gene which encodes the intestinal (hRFT2) riboflavin transporter...
  58. ncbi Structure and mechanism of the S component of a bacterial ECF transporter
    Peng Zhang
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA
    Nature 468:717-20. 2010
    ..Here we report the crystal structure of RibU, the S component of the ECF-type riboflavin transporter from Staphylococcus aureus at 3.6-Å resolution...
  59. ncbi Early use of high-dose riboflavin in a case of Brown-Vialetto-Van Laere syndrome
    Geetha Anand
    Department of Paediatrics, John Radcliffe Hospital, Oxford, UK
    Dev Med Child Neurol 54:187-9. 2012
    ..BVVLS) is a genetic condition caused by a mutation in the C20orf54 gene, which also codes for an intestinal riboflavin transporter...
  60. ncbi Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase
    Markus Fischer
    Institute of Food Chemistry, University of Hamburg, Grindelallee 117, D 20146 Hamburg, Germany
    Arch Biochem Biophys 474:252-65. 2008
    The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates...
  61. ncbi Pharmacological modification of the epithelial permeability by benzalkonium chloride in UVA/Riboflavin corneal collagen cross-linking
    Anja Kissner
    Department of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, Germany
    Curr Eye Res 35:715-21. 2010
    To examine the biomechanical effect and the UVA-absorption of a riboflavin/UVA cross-linking method, which suggests leaving the epithelium intact and applying benzalkonium chloride (BAC) on rabbits' corneas.
  62. ncbi Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusis
    Farhad Hafezi
    Institute for Refractive and Ophthalmic Surgery, Zurich, Switzerland
    J Cataract Refract Surg 33:2035-40. 2007
    To determine whether riboflavin and ultraviolet-A (UVA) corneal crosslinking can be used as an alternative therapy to prevent the progression of keratectasia.
  63. ncbi Corneal collagen cross-linking with riboflavin and UVA irradiation in pellucid marginal degeneration
    Leopoldo Spadea
    Department of Surgical Sciences, Eye Clinic, University of L Aquila, Italy
    J Refract Surg 26:375-7. 2010
    To report the results of corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A irradiation in a patient affected by pellucid marginal degeneration (PMD).
  64. ncbi Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs
    C Di Lorenzo
    University Centre for Adaptive Disorders and Headache, University of Rome La Sapienza, Polo Pontino ICOT, Latina, Italy
    Neurology 72:1588-94. 2009
    In migraine, an interictal reduction of mitochondrial energy metabolism and a preventive effect of high-dose riboflavin were reported...
  65. ncbi Corneal crosslinking: riboflavin concentration in corneal stroma exposed with and without epithelium
    Stefano Baiocchi
    Department of Ophthalmology, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    J Cataract Refract Surg 35:893-9. 2009
    To evaluate intrastromal concentrations of riboflavin with and without epithelium to ensure the efficacy and safety of corneal crosslinking (CXL) by the standard and transepithelial procedures.
  66. ncbi Corneal biomechanical changes after collagen cross-linking from porcine eye inflation experiments
    Sabine Kling
    Instituto de Optica, Daza de Valdés, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Invest Ophthalmol Vis Sci 51:3961-8. 2010
    ..The authors studied the corneal response to variable intraocular pressure (IOP) in porcines eyes after UV collagen cross-linking (CXL), in comparison with untreated eyes...
  67. ncbi Riboflavin and ultraviolet a collagen crosslinking of the cornea for the treatment of keratitis
    Håkan Morén
    Department of Ophthalmology, Regional Hospital of Västerås, Vasteras, Sweden
    Cornea 29:102-4. 2010
    To describe riboflavin and ultraviolet light (UV) collagen crosslinking as an effective treatment for infectious keratitis.
  68. ncbi Corneal collagen crosslinking for keratoconus and corneal ectasia: One-year results
    Peter S Hersh
    Cornea and Laser Eye Institute Hersh Vision Group, CLEI Center for Keratoconus, Teaneck, New Jersey 07666, USA
    J Cataract Refract Surg 37:149-60. 2011
    ..To evaluate 1-year outcomes of corneal collagen crosslinking (CXL) for treatment of keratoconus and corneal ectasia...
  69. pmc Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA)
    A Scott McCall
    Division of Biology, Kansas State University, Manhattan, Kansas 66506 4901, USA
    Invest Ophthalmol Vis Sci 51:129-38. 2010
    Treatment of de-epithelialized human corneas with riboflavin (RF) + long-wavelength ultraviolet light (UVA; RFUVA) increases corneal stroma tensile strength significantly...
  70. pmc Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment
    Annet M Bosch
    Department of Pediatrics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Inherit Metab Dis 34:159-64. 2011
    ..Subsequently, a profound flavin deficiency in spite of a normal dietary riboflavin intake was established in the plasma of all three children, suggesting a riboflavin transporter defect...
  71. pmc Characterization of riboflavin (vitamin B2) transport proteins from Bacillus subtilis and Corynebacterium glutamicum
    Christian Vogl
    Lehrstuhl für Ernährungsphysiologie, Technische Universitat Munchen, Am Forum 5, 85350, Freising Weihenstephan, Germany
    J Bacteriol 189:7367-75. 2007
    b>Riboflavin (vitamin B(2)) is the direct precursor of the flavin cofactors flavin mononucleotide and flavin adenine dinucleotide, essential components of cellular biochemistry...
  72. ncbi Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer
    Stefan de Vogel
    Departments of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    J Nutr 138:2372-8. 2008
    Adequate intake of folate, methionine, riboflavin, and vitamin B-6 may prevent aberrant DNA methylation and thereby protect against colorectal cancer (CRC)...
  73. ncbi Transepithelial corneal collagen cross-linking in keratoconus
    Antonio Leccisotti
    School of Biomedical Sciences, University of Ulster, Coleraine, UK
    J Refract Surg 26:942-8. 2010
    ..To evaluate the clinical effects of transepithelial corneal cross-linking (CXL) on keratoconic eyes pre-treated with substances enhancing epithelial permeability...
  74. pmc Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria
    Jeremy D Selengut
    J Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
    J Bacteriol 192:5788-98. 2010
    ..These findings suggest that M. tuberculosis relies heavily on coenzyme F(420) for its redox reactions. This dependence and the cofactor's rarity may make F(420)-related proteins promising drug targets...
  75. ncbi Keratocyte apoptosis after corneal collagen cross-linking using riboflavin/UVA treatment
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Dresden, Germany
    Cornea 23:43-9. 2004
    Combined riboflavin/UVA treatment inducing collagen cross-links in the cornea has been shown to increase the biomechanical rigidity of the cornea and has been used successfully in the treatment of progressive keratoconus...
  76. ncbi Escherichia coli keratitis treated with ultraviolet A/riboflavin corneal cross-linking: a case report
    Tommaso Micelli Ferrari
    UOC Oculistica, Ospedale Generale Regionale F Miulli, Acquaviva delle Fonti, Bari Italy
    Eur J Ophthalmol 19:295-7. 2009
    To describe a case of keratitis caused by the Gram-negative Escherichia coli, treated with UVA-riboflavin cross linking.
  77. pmc Large-scale production of coenzyme F420-5,6 by using Mycobacterium smegmatis
    Dale Isabelle
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Environ Microbiol 68:5750-5. 2002
    ..An improved chromatography system using rapidly flowing quaternary aminoethyl ion-exchange material and Florisil was used to more quickly and easily purify F420 than with previous methods...
  78. ncbi Riboflavin and ultraviolet light a therapy as an adjuvant treatment for medically refractive Acanthamoeba keratitis: report of 3 cases
    Yasin A Khan
    The Wilmer Ophthalmological Institute, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Ophthalmology 118:324-31. 2011
    To present the first 3 cases of Acanthamoeba keratitis (AK), unresponsive to medical treatment, that were successfully treated with a novel adjunctive therapy using ultraviolet light A (UVA) and riboflavin (B2).
  79. pmc Identification and characterization of two families of F420 H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation
    Matthew C Taylor
    CSIRO Ecosystem Sciences, GPO Box 1700, Canberra, ACT 2601, Australia
    Mol Microbiol 78:561-75. 2010
    ....
  80. ncbi Potential use of riboflavin/UVA cross-linking in bullous keratopathy
    Gregor Wollensak
    Eye Laser Institute, Department of Ophthalmology, Martin Luther University, Halle, Germany
    Ophthalmic Res 41:114-7. 2009
    ..Collagen cross-linking of the cornea has been shown by us to have an antiedematous effect in the cornea. The aim of the present study was to examine if this effect can be used for the treatment of bullous keratopathy...
  81. ncbi Effect of epithelial retention and removal on riboflavin absorption in porcine corneas
    Konstantinos Samaras
    Department of Ophthalmology, St Thomas Hospital, London, United Kingdom
    J Refract Surg 25:771-5. 2009
    To compare stromal riboflavin absorption after 20% alcohol application and partial or complete epithelial removal by analyzing light transmission properties of porcine corneas after riboflavin/ultraviolet A (UVA) corneal collagen cross-..
  82. ncbi Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications
    Cosimo Mazzotta
    Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    Am J Ophthalmol 146:527-533. 2008
    ..To assess early and late micromorphological modifications of cross-linked corneas in vivo by means of Heidelberg Retinal Tomography (HRT) II confocal microscopy...
  83. pmc Genetic control of biosynthesis and transport of riboflavin and flavin nucleotides and construction of robust biotechnological producers
    Charles A Abbas
    Archer Daniels Midland Company, Decatur, Illinois 625261, USA
    Microbiol Mol Biol Rev 75:321-60. 2011
    b>Riboflavin [7,8-dimethyl-10-(1'-d-ribityl)isoalloxazine, vitamin B₂] is an obligatory component of human and animal diets, as it serves as the precursor of flavin coenzymes, flavin mononucleotide, and flavin adenine dinucleotide, which ..
  84. ncbi Brown-Vialetto-Van Laere syndrome: a riboflavin-unresponsive patient with a novel mutation in the C20orf54 gene
    Anne Koy
    Department of General Pediatrics and Neonatology, University Children s Hospital, Dusseldorf, Germany
    Pediatr Neurol 46:407-9. 2012
    ..They benefited from riboflavin. We describe a 3-year-old girl with early-onset Brown-Vialetto-Van Laere syndrome and a novel mutation in the ..
  85. ncbi Significance of the riboflavin film in corneal collagen crosslinking
    Gregor Wollensak
    Department of Ophthalmology, Eye Laser Institute, Martin Luther University, Halle, Germany
    J Cataract Refract Surg 36:114-20. 2010
    To evaluate the role of the preocular riboflavin film in ultraviolet-A (UVA) absorption in corneal collagen crosslinking (CXL).
  86. ncbi Corneal endothelial cytotoxicity of riboflavin/UVA treatment in vitro
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Dresden, Germany
    Ophthalmic Res 35:324-8. 2003
    Recently, we have developed collagen crosslinking induced by combined riboflavin/UVA treatment, thus increasing the biomechanical rigidity of the cornea to treat progressive keratoconus...
  87. ncbi Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii
    Lorenz Chatwell
    Max Planck Institut fur Biochemie, Abteilung für Strukturforschung, Martinsried, Germany
    J Mol Biol 359:1334-51. 2006
    The pyrimidine reductase of the riboflavin biosynthetic pathway (MjaRED) specified by the open reading frame MJ0671 of Methanocaldococcus jannaschii was expressed in Escherichia coli using a synthetic gene...
  88. ncbi The improvement of riboflavin production in Ashbya gossypii via disparity mutagenesis and DNA microarray analysis
    Enoch Y Park
    Laboratory of Biotechnology, Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, 836 Ohya Suruga ku, Shizuoka 422 8529, Japan
    Appl Microbiol Biotechnol 91:1315-26. 2011
    We generated a high riboflavin-producing mutant strain of Ashbya gossypii by disparity mutagenesis using mutation of DNA polymerase δ in the lagging strand, resulting in loss of DNA repair function by the polymerase...
  89. ncbi Functional characteristics of apheresis-derived platelets treated with ultraviolet light combined with either amotosalen-HCl (S-59) or riboflavin (vitamin B2) for pathogen-reduction
    S M Picker
    Transfusion Medicine, University of Cologne, Germany
    Vox Sang 97:26-33. 2009
    ..To examine if different pathogen-reduction technologies (PRTs) induce different degrees of platelet (PLT) storage lesion...
  90. ncbi Riboflavin deficiency induces ocular surface damage
    Yumiko Takami
    Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan
    Ophthalmic Res 36:156-65. 2004
    To examine the conjunctiva and cornea of riboflavin-deficient rats with scanning (SEM) and transmission (TEM) electron microscopes.
  91. ncbi Transport of high concentration of thiamin, riboflavin and pyridoxine across intestinal epithelial cells Caco-2
    Magdalena Zielińska-Dawidziak
    Department of Biotechnology and Food Microbiology, University of Life Sciences in Poznan
    J Nutr Sci Vitaminol (Tokyo) 54:423-9. 2008
    In this study, we examined the intestinal uptake of thiamin (vitamin B(1)), riboflavin (vitamin B(2)) and pyridoxine (vitamin B(6)) administered at high concentration using intestinal epithelial Caco-2 cells as an in vitro model of drugs ..
  92. ncbi Current perspectives on the cellular uptake and trafficking of riboflavin
    Amy B Foraker
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA
    Adv Drug Deliv Rev 55:1467-83. 2003
    The role of riboflavin in cell maintenance and growth, and the mechanism by which it is absorbed into various human tissues and cell lines has been extensively studied over the past decade...
  93. ncbi Safety of corneal collagen cross-linking with UV-A and riboflavin in progressive keratoconus
    Yakov Goldich
    Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel
    Cornea 29:409-11. 2010
    To assess the possible damage to ocular tissues during treatment of keratoconus with UV-A-riboflavin corneal collagen cross-linking (CXL).
  94. pmc In vitro activity of riboflavin against the human malaria parasite Plasmodium falciparum
    T Akompong
    Departments of Pathology and Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    Antimicrob Agents Chemother 44:88-96. 2000
    ..2%) found in normal, uninfected erythrocytes. Further, treatment of infected cells with the reducing agent riboflavin for 24 h decreased the parasite methemoglobin level by 55%...
  95. ncbi Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in Bacillus subtilis
    Yun Xia Duan
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China
    Appl Microbiol Biotechnol 85:1907-14. 2010
    ..of carbon flow into the PP pathway will affect the availability of ribulose-5-phosphate (Ru5P) and the riboflavin yield...
  96. ncbi Pathogen inactivation of blood components: current status and introduction of an approach using riboflavin as a photosensitizer
    Frank Corbin
    Research and Development, Gambro BCT, Inc, USA
    Int J Hematol 76:253-7. 2002
    b>Riboflavin is a naturally occurring compound and an essential human nutrient. Studies in the 1960s and 70s showed that it could be effective, when exposed to visible or UV light, in inactivating viruses and bacteria...
  97. ncbi Effect of riboflavin-fortified salt nutrition intervention on esophageal squamous cell carcinoma in a high incidence area, China
    Yutong He
    the Fourth Affiliated Hospital of Hebei Medical University, Hebei Cancer Institute, Shijiazhuang, China
    Asian Pac J Cancer Prev 10:619-22. 2009
    b>Riboflavin-fortified salt is now supplied in the diet for residents who live in high incidence areas for esophageal squamous cell carcinoma in China.
  98. ncbi Dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in early adolescence: the Ryukyus Child Health Study
    Kentaro Murakami
    Department of Social and Preventive Epidemiology, School of Public Health, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Psychosom Med 72:763-8. 2010
    To examine the association between dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in a group of adolescents.
  99. ncbi Assessing efficacy of combined riboflavin and UV-A light (365 nm) treatment of Acanthamoeba trophozoites
    Renata T Kashiwabuchi
    Department of Ophthalmology, Paulista School of Medicine, Federal University of Sao Paulo, UNIFESP, Sao Paulo, Brazil
    Invest Ophthalmol Vis Sci 52:9333-8. 2011
    To assess the Acanthamoeba trophozoite viability in vitro and treatment of Acanthamoeba keratitis in a hamster model using ultraviolet light A (UV-A) and riboflavin (B2).
  100. ncbi Riboflavin analogs and inhibitors of riboflavin biosynthesis
    Matthias Mack
    Institute for Technical Microbiology, Mannheim University of Applied Sciences, Germany
    Appl Microbiol Biotechnol 71:265-75. 2006
    Flavins are active components of many enzymes. In most cases, riboflavin (vitamin B(2)) as a coenzyme represents the catalytic part of the holoenzyme...
  101. ncbi Immunoglobulins can utilize riboflavin (Vitamin B2) to activate the antibody-catalyzed water oxidation pathway
    Jorge Nieva
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Immunol Lett 103:33-8. 2006
    ..cofactors, that are known to be endogenous photosensitizers via Type-II pathways to generate (1)O(2)(*), such as riboflavin (RF, Vitamin B2) can trigger the ACWOP...

Research Grants62

  1. FIBROBLAST DIFFERENTIATION DURING EYE DEVELOPMENT
    Gary W Conrad; Fiscal Year: 2012
    ..2) Another clinically important physical manipulation of corneal ECM, combined riboflavin and ultraviolet light (UVA) administration, has begun trials in the U.S. as a treatment for keratoconus...
  2. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..E, zinc) or promote it (iron, saturated fat);2) methyl group metabolism - betaine, choline, folate, methionine, riboflavin, vitamin B6, vitamin B12, zinc;and 3) glycemic control - dietary glycemic load;intake of glucose, sucrose, ..
  3. Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
    Eunyoung Cho; Fiscal Year: 2012
    ..Several dietary factors including folate, alcohol, methionine, riboflavin, vitamins B6 and B12, choline, and betaine mediate or facilitate one-carbon metabolism pathway...
  4. Therapeutic Corneal Cross-linking Using Aliphatic Beta-Nitroalcohols
    David C Paik; Fiscal Year: 2013
    ..group of Wollensak, Spoerl, and Seiler has shown that cross-linking corneal collagen through application of riboflavin and ultraviolet light (UVAR) can limit progressive vision loss in keratoconus patients...
  5. Risk Factors for Craniosynostosis
    Suzan L Carmichael; Fiscal Year: 2010
    ..risk of CS among offspring, including folate/folic acid, choline, betaine, methionine, vitamin B12, vitamin B6, riboflavin, glycemic load, [unreadable]-carotene, vitamin E, and vitamin C. Aim 2. Factors related to thyroid dysfunction...
  6. Intestinal Vitamin B2 Absorption: Molecular/Cellular Aspects and Effects of Alcoh
    Hamid M Said; Fiscal Year: 2013
    ..to characterize the molecular mechanisms involved in the regulation of the intestinal absorption of vitamin B2 (riboflavin, RF), and those involved in intracellular trafficking and membrane targeting of the involved membrane ..
  7. Optimizing Wolbachia manipulation in mosquito cell lines
    Ann M Fallon; Fiscal Year: 2013
    ..recovery of transformed Wolbachia, a mosquito cell line will be made dependent on Wolbachia by engineering the riboflavin biosynthetic pathway...
  8. Structural Biology of Purine and Pyrimidine Biosynthesis and Metabolism
    Steven E Ealick; Fiscal Year: 2012
    ..These reactions are usually associated with purine-derived metabolites such as folate, riboflavin and molypdopterin, suggesting a widespread utilization of purines in the biosynthesis of additional metabolites...
  9. MECHANISM BASED INHIBITION OF M TUBERCULOSIS ENZYMES
    John S Blanchard; Fiscal Year: 2012
    ..will focus on the ribG-encoded bifunctional deaminase-reductase that is the second step in the biosynthesis of riboflavin. Finally, we will initiate studies on the M. tuberculosis blaC-encoded beta-lactamase...
  10. Flavoenzymes in Pyrimidine Metabolism
    Bruce A Palfey; Fiscal Year: 2011
    ..Our studies of the rates of the chemical reactions will identify important parts of the proteins, how they move during reactions, how they speed the synthesis of products, and how these reactions might be blocked. ..
  11. Naltrexone for the treatment of Actively-Using Met-Dependent MSM with High-Risk B
    Susan Buchbinder; Fiscal Year: 2013
    ..placebo by evaluating adherence via medication event monitoring systems (MEMS) caps, urine ss-naltrexol, urine riboflavin, and self-report...
  12. EFFECTS OF ADRIAMYCIN AND BCNU ON GLUTATHIONE
    Henry Kaplan; Fiscal Year: 1980
    ..Enzyme activity will be correlated with cell kill. Enzyme activity will be manipulated by addition of riboflavin or riboflavin antagonists to the medium...
  13. Repair of Focal Defects in the Annulus Fibrosus Using Injectable High-Density Col
    BRANDON BORDE; Fiscal Year: 2013
    ..2007). Likewise, crosslinking with a nontoxic agent like riboflavin increases gel stiffness...
  14. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..E, C and B-carotene); (2) they are essential for the function of enzyme antioxidants (Zn, Cu, Fe, Mn, Se and riboflavin); or (3) they act to maintain low levels of potentially pro-oxidant molecules (vitamins B12, B6 and folate)...
  15. VITAMIN B2 AND B6 IN VERY LOW BIRTH WEIGHT INFANTS
    LARRY SWIFT; Fiscal Year: 1992
    ..data indicate that the manufacturer's recommended dosage results in a 100-400 fold increase in plasma riboflavin and marked increases in plasma B6 vitamers were also noted with the current recommended dose of pyridoxine...
  16. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..heated and unheated milk we will measure and compare: a) concentrations of vitamins A, ascorbic acid, thiamine, riboflavin, pyridoxine, folate and B12, known to be relatively heat-sensitive; b) concentration and digestability of ..
  17. REDOX PROPERTIES OF FLAVODOXIN-LIKE FLAVOPROTEINS
    RICHARD SWENSON; Fiscal Year: 2007
    ..Linked through their common utilization of riboflavin-based cofactors, these proteins catalyze essential oxidation-reduction steps in almost every metabolic pathway ..
  18. Novel Treatment for Post-LASIK Ectasia
    MATTHEW MATTSON; Fiscal Year: 2009
    ..Corneal crosslinking using the riboflavin/UVA protocol pioneered by Wollensak, Seiler, and Spoerl, has shown promise in halting the progress of post-LASIK ..
  19. VITAMIN DELIVERY BY PLACENTA
    Richard Rose; Fiscal Year: 1990
    ..Efforts will be directed at understanding the transfer of nicotinic acid, Riboflavin, pantothenic acid, thiamine, ascorbic acid and the product of ascorbic acid oxidation, dehydroascorbic acid...
  20. CARNITINE ACYLTRANSFERASE CHARACTERISTICS
    Linda Brady; Fiscal Year: 1993
    ..CPT activity and synthesis increased in starvation, diabetes, with administration of hypolipidemic drugs, in riboflavin deficiency, and with increased dietary fat...
  21. A Novel Treatment for Keratoconus and Keratectasias using Nitro Technology
    David C Paik; Fiscal Year: 2010
    ..group of Wollensak, Spoerl, and Seiler has shown that cross-linking corneal collagen through application of riboflavin and ultraviolet light (UVR) can limit progressive vision loss in keratoconus patients...
  22. PERIODONTITIS AND SYSTEMIC DISEASE: CONFOUNDING?
    Philippe Hujoel; Fiscal Year: 2001
    ..adjustment for age and gender, were more likely to have an unhealthy diet (less fruit, less vitamin C, less riboflavin, and less linoleic acid), were more likely to have suffered a nervous breakdown, less likely to exercise, more ..
  23. MECHANISTIC PROBES OF FLAVOENZYME CATALYSIS
    Christopher Walsh; Fiscal Year: 1992
    ..We are in the process of cloning and sequencing the gene from various trypanosomatids and will continue molecular biology and enzymology studies on this enzyme, likely target for antiparasitic agents...
  24. RIBOFLAVIN AND FLAVOPROTEIN GENE EXPRESSION
    NATHAN ROSS; Fiscal Year: 1993
    ..The specific aims are to use in vivo and in vitro models of riboflavin deficiency to study the role of that vitamin in regulating the expression of the short-chain acyl-CoA ..
  25. CRYSTAL STRUCTURES OF ANTIBODIES AND IDIOTYPIC CASCADE
    BRADFORD BRADEN; Fiscal Year: 1999
    ..of that structure to the mechanism of catalysis of a lumazine synthase, a key enzyme in the production of riboflavin, from Brucella bacterium. Bacteria are devoid of an uptake system for riboflavin...
  26. A TRAIL OF MICRONUTRIENTS AND ADVERSE PREGNACY OUTCOMES
    Wafaie Fawzi; Fiscal Year: 2003
    ..Compliance will be examined by pill count and measurement of urine riboflavin and plasma ferritin levels in a random subsample...
  27. INHERITED DISORDERS OF OXIDATIVE METABOLISM IN MAN
    William Rhead; Fiscal Year: 1991
    ..The MAD result from deficiencies of electron transfer flavorprotein (ETF) or ETF-dehydrogenase (ETF-DH); riboflavin-responsive (RR) MAD/M variants are known...
  28. IMPORTANT FACTORS IN THE REGULATION OF IRON ABSORPTION
    RICHARD TOPHAM; Fiscal Year: 1992
    ..dietary iron and to attempt to determine the molecular bases for the impairment of iron absorption observed in riboflavin deficiency...
  29. EFFECTS OF AGE & RIBOFLAVIN ON B-ADRENERGIC ACTIVITIES
    PURABI DUTTA; Fiscal Year: 1990
    ..We propose that nutritional status in general and the deficiency of riboflavin in particular may modulate these age- related changes...
  30. COGNITIVE EFFECTS OF SUGAR DIETS ON CHILDREN
    Mark Wolraich; Fiscal Year: 1990
    ..These will be assessed for serum glucose and phenylalanine levels. We will collect urine samples weekly to assess markers in the diet (abscorbic acid and riboflavin) confirming compliance.
  31. FLAVOENZYME MECHANISMS: REDOX AND NON-REDOX REACTIONS
    MARILYN JORNS; Fiscal Year: 2007
    ..member of a superfamily of amine-oxidizing enzymes that contain covalently bound derivatives of the vitamin riboflavin. MSOX is an important catabolic enzyme commonly found in soil bacteria and widely used in the clinical ..
  32. STRUCTURAL STUDIES OF UNIQUE MYELOMA IMMUNOGLOBULINS
    FREDERICK GARVER; Fiscal Year: 1980
    ..IgG GAR is a gamma 2 myeloma protein which binds riboflavin and contains lambda-type L chains...
  33. B-Vitamin Intake and Blood Pressure: The INTERMAP Study
    Linda Van Horn; Fiscal Year: 2003
    ..These data indicate that lower dietary thiamin, riboflavin, B6, and folate (considered singly) is associated with higher systolic BP (SBP), and plays a role in the higher ..
  34. ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERS
    Charles Lieber; Fiscal Year: 2005
    ..For both PPC and ribavirin, compliance will be monitored by incorporation of markers, such as riboflavin, that can be measured in the urine...
  35. BIOSYNTHESIS OF RIBOFLAVIN AND RELATED COMPOUNDS
    HEINZ FLOSS; Fiscal Year: 1991
    Following the identification of the 4-carbon units making up the o-xylene moiety, biosynthetic studies on riboflavin will be continued with major emphasis on elucidating mechanistic aspects of the conversion of ribulose 5-phosphate into ..
  36. PROTEIN BINDING SITES BY REDOR NMR
    Jacob Schaefer; Fiscal Year: 2002
    ..2) 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) synthase, 3) UDP-GlcNac enolpyruvyltransferase, 4) riboflavin synthase and 5) human factor Xa...
  37. ZINC AND IRON SUPPLEMENTATION: IMPACT ON DEVELOPMENT
    Maureen Black; Fiscal Year: 2002
    ..The trial had four cells: riboflavin with and without zinc, and other micronutrients [riboflavin, calcium, phosphorus, folate, and iron] with and ..
  38. NALTREXONE TREATMENT OF ALCOHOL DEPENDENCE
    Joseph Volpicelli; Fiscal Year: 2002
    ..Medication compliance will be assessed by pill counts, urine screens for riboflavin and for those subjects on active medication by serum levels of naltrexone and beta-naltrexol...
  39. Tuning-Up Human Metabolism
    Bruce Ames; Fiscal Year: 2005
    ..g. homocysteine accumulation in MTHFR: riboflavin; alcohol intolerance in half of Asians: niacin...
  40. RIBOFLAVIN BINDING PROTEIN PROMOTER
    MARILEE PARSONS; Fiscal Year: 1999
    b>Riboflavin Binding Protein (RBP) is synthesized in the liver and oviduct of a laying hen and transports Riboflavin to the egg where it later sustains the development of the chick...
  41. BIOCHEMICAL LENS DAMAGE AND CATARACT RISK FACTORS
    Giovanni Maraini; Fiscal Year: 1990
    ..Factors under investigation include epithelial enzymes, evaluation of thiamine and riboflavin status, sugar alcohols, water and ion content...
  42. Maximizing CBT's Efficacy with Medication & CM
    Kathleen Carroll; Fiscal Year: 2009
    ..Compliance with disulfiram treatment will be monitored by the riboflavin tracer procedure...
  43. Epithelial Transport and Function of Riboflavin
    Peter Swaan; Fiscal Year: 2003
    b>Riboflavin (RF), a water-soluble vitamin, is essential for normal cellular functions and growth. During periods of dietary deprivation or physiological and pathological stress humans are vulnerable to developing RF deficiency...
  44. A new tumor marker for Ovarian Cancer
    Madhwa Raj; Fiscal Year: 2007
    ..This property can be potentially used as a marker to detect the presence of the cancer. Riboflavin Carrier Protein (RCP) is an estrogen induced growth and development specific protein...
  45. Pharmacotherapy for Cocaine Dependence
    John Grabowski; Fiscal Year: 2005
    ..of PBO, 45 mg, 60 mg, or 80 mg administered in identical capsules. Rigorous compliance measures using riboflavin, urine screens, and MEMS dispensing bottles will be applied...
  46. Mechanism/regulation of human intestinal thiamin uptake
    HAMID SAID; Fiscal Year: 2008
    ..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
  47. Synthesis of New NNRTLs for the Treatment of AIDS
    Mark Cushman; Fiscal Year: 2005
    ..The activities of the ADAMs vs. NNRTI resistant viruses will be investigated. The aqueous solubilities of the new ADAMs will be measured accurately. ..
  48. C elegans:a model to study intestinal water-soluble vitamins transport in vivo
    HAMID SAID; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  49. LIGANDS FOR PROBING THE ACTIVE SITE OF LUMAZINE SYNTHASE
    Mark Cushman; Fiscal Year: 2008
    DESCRIPTION (provided by applicant) Lumazine synthase catalyzes the penultimate step in riboflavin biosynthesis and is therefore essential for the existence of life as we know it on earth...
  50. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002
    ..abstract_text> ..
  51. Mycobacterium tuberculosis-reactive thymocytes
    MARIELLE GOLD; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. Na+-pumping NADH:quinone oxidoreductase of V. cholerae
    Blanca Barquera; Fiscal Year: 2009
    ..We will also make a strong effort to crystallize Na+-NQR, since a 3-dimensional structural model is essential for a molecular-level understanding of the mechanism of the enzyme. ..
  53. Evaluating Errors in Reported Use of Dietary Supplements
    Suzanne Murphy; Fiscal Year: 2007
    ..abstract_text> ..
  54. HTS on Riboflavin and Terpene Biosynthetic Enzymes(RMI)
    Adelbert Bacher; Fiscal Year: 2005
    ..Specifically, assays will be developed for 4 enzymes of the non-mevalonate pathway and for 3 assays of the riboflavin pathway...
  55. Serum Total Homocysteine and C-Reactive Protein as Pred
    Andrew Bostom; Fiscal Year: 2002
    ....
  56. MOSQUITO IMMUNITY FUNCTIONS
    Ann Fallon; Fiscal Year: 2003
    ..The work will include identification of exon-intron organization and recovery of upstream flanking DNA, which will be analyzed for potential regulatory elements. ..
  57. INTEGRATED TREATMENT FOR COCAINE AND MOOD DISORDERS
    Joy Schmitz; Fiscal Year: 2003
    ....