opipramol

Summary

Summary: A tricyclic antidepressant with actions similar to AMITRIPTYLINE.

Top Publications

  1. ncbi Kava-Kava extract LI 150 is as effective as Opipramol and Buspirone in Generalised Anxiety Disorder--an 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients
    R J Boerner
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Phytomedicine 10:38-49. 2003
  2. ncbi Neuropharmacology of the anxiolytic drug opipramol, a sigma site ligand
    W E Muller
    Department of Pharmacology, Biocenter University Frankfurt, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    Pharmacopsychiatry 37:S189-97. 2004
  3. ncbi Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo
    T S Rao
    CNS Diseases Research, G D Searle and Co, Monsanto Company, St Louis, Missouri 63198
    Neuropharmacology 29:1191-7. 1990
  4. ncbi Spectroscopic investigation (FT-IR, FT-Raman and SERS), vibrational assignments, HOMO-LUMO analysis and molecular docking study of Opipramol
    Y Sheena Mary
    Department of Physics, Fatima Mata National College, Kollam, Kerala, India
    Spectrochim Acta A Mol Biomol Spectrosc 137:547-59. 2015
  5. ncbi Repetitive injection field-amplified sample stacking for cationic compounds determination
    Szymon Dziomba
    Department of Pharmaceutical Chemistry, Medical University of Gdansk, Hallera 107, 80 416 Gdansk, Poland
    Talanta 125:1-6. 2014
  6. ncbi Cutaneous manifestations of injectable drug use: hidden secrets
    Wioletta Barańska-Rybak
    Department of Dermatology, Venereology, and Allergology, Medical University of Gdansk, Debinki St 7, 80 211 Gdansk, Poland
    Cutis 93:185-7. 2014
  7. ncbi A retrospective analysis of antidepressant poisonings in the emergency department: 11-year experience
    P Unverir
    Department of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey
    Hum Exp Toxicol 25:605-12. 2006
  8. ncbi Combined pH/organic solvent gradient HPLC in analysis of forensic material
    Paweł Wiczling
    Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Gen J Hallera 107, 80 416 Gdansk, Poland
    J Pharm Biomed Anal 37:871-5. 2005
  9. ncbi Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography-electrospray ionization mass spectrometry
    Ursula Gutteck
    Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Clin Chem Lab Med 41:1571-9. 2003
  10. ncbi 2,2'-Bipyridine as a new and sensitive spectrophotometric reagent for the determination of nanoamounts of certain dibenzazepine class of tricyclic antidepressant drugs
    Ayesha Syeda
    Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
    Farmaco 60:47-51. 2005

Research Grants

  1. Expanding the therapeutic window for stroke treatment.
    KEITH PENNYPACKER; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications52

  1. ncbi Kava-Kava extract LI 150 is as effective as Opipramol and Buspirone in Generalised Anxiety Disorder--an 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients
    R J Boerner
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Phytomedicine 10:38-49. 2003
    ..An 8-week randomized, reference-controlled, double-blind, multi-centre clinical trial investigated Kava-Kava LI 150 in Generalized Anxiety Disorder (GAD; ICD-10: F41.1)...
  2. ncbi Neuropharmacology of the anxiolytic drug opipramol, a sigma site ligand
    W E Muller
    Department of Pharmacology, Biocenter University Frankfurt, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    Pharmacopsychiatry 37:S189-97. 2004
    Although opipramol is structurally related to imipramine, it does not represent a tricyclic antidepressant drug as it does not inhibit the neuronal uptake of norepinephrine and/or serotonin...
  3. ncbi Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo
    T S Rao
    CNS Diseases Research, G D Searle and Co, Monsanto Company, St Louis, Missouri 63198
    Neuropharmacology 29:1191-7. 1990
    b>Opipramol, a tricyclic antidepressant drug, potently interacted with sigma recognition sites labelled by [3H](+)-3-hydroxyphenyl)N-(1-propyl)piperidine [( 3H](+)-3-PPP) with a Ki value of 50 +/- 8 nM and with minimal affinity for ..
  4. ncbi Spectroscopic investigation (FT-IR, FT-Raman and SERS), vibrational assignments, HOMO-LUMO analysis and molecular docking study of Opipramol
    Y Sheena Mary
    Department of Physics, Fatima Mata National College, Kollam, Kerala, India
    Spectrochim Acta A Mol Biomol Spectrosc 137:547-59. 2015
    FT-IR and FT-Raman spectra of Opipramol were recorded and analyzed. SERS spectrum was recorded in silver colloid. The vibrational wave numbers were computed using DFT quantum chemical calculations...
  5. ncbi Repetitive injection field-amplified sample stacking for cationic compounds determination
    Szymon Dziomba
    Department of Pharmaceutical Chemistry, Medical University of Gdansk, Hallera 107, 80 416 Gdansk, Poland
    Talanta 125:1-6. 2014
    ..65 min. The method was developed for the determination of six psychiatric drugs (opipramol, hydroxyzine, promazine, amitriptyline, fluoxetine, and thioridazine)...
  6. ncbi Cutaneous manifestations of injectable drug use: hidden secrets
    Wioletta Barańska-Rybak
    Department of Dermatology, Venereology, and Allergology, Medical University of Gdansk, Debinki St 7, 80 211 Gdansk, Poland
    Cutis 93:185-7. 2014
    ..diaphoresis, fatigue, recent weight loss, and agitation following subcutaneous injection of a tramadol, opipramol, and clonazepam mixture...
  7. ncbi A retrospective analysis of antidepressant poisonings in the emergency department: 11-year experience
    P Unverir
    Department of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey
    Hum Exp Toxicol 25:605-12. 2006
    ..A total of 356 antidepressant poisoning cases were evaluated. Tricyclic antidepressants (TCA), especially opipramol and amitriptyline, were the most common agents (58.4%). The most frequent ECG finding was sinus tachycardia (40...
  8. ncbi Combined pH/organic solvent gradient HPLC in analysis of forensic material
    Paweł Wiczling
    Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Gen J Hallera 107, 80 416 Gdansk, Poland
    J Pharm Biomed Anal 37:871-5. 2005
    ..Advantages of the method are illustrated in postmortem analysis of opipramol in material from suicide victims...
  9. ncbi Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography-electrospray ionization mass spectrometry
    Ursula Gutteck
    Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Clin Chem Lab Med 41:1571-9. 2003
    ..doxepin (including nordoxepin), escitalopram, flupentixol, fluphenazine, fluvoxamine, imipramine, nortriptyline, opipramol, pipamperone, reboxetine, thioridazine, trimipramine and zuclopenthixol were separated on a reversed-phase C18 ..
  10. ncbi 2,2'-Bipyridine as a new and sensitive spectrophotometric reagent for the determination of nanoamounts of certain dibenzazepine class of tricyclic antidepressant drugs
    Ayesha Syeda
    Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
    Farmaco 60:47-51. 2005
    ..IPH), desipramine hydrochloride (DPH), clomipramine hydrochloride (CPH), trimipramine maleate (TPM) and opipramol (OPP) with iron (III) and subsequent reaction with 2,2'-bipyridine in an acetic acid medium to yield a pink ..
  11. ncbi High-resolution structures of Neotermes koshunensis β-glucosidase mutants provide insights into the catalytic mechanism and the synthesis of glucoconjugates
    Wen Yih Jeng
    Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan
    Acta Crystallogr D Biol Crystallogr 68:829-38. 2012
    ..found that new glucoconjugates were generated by the conjugation of glucose (hydrolyzed product) and HEPES/EPPS/opipramol (buffer components)...
  12. ncbi [Modification of perioperative psychiatric drug therapy]
    Andreas Redel
    Klinik für Anästhesiologie der Universität Regensburg, Germany
    Anasthesiol Intensivmed Notfallmed Schmerzther 48:10-7. 2013
    ..In this article we use the available data to answer the question of a journal reader regarding the perioperative modification of Opipramol therapy for a 59-year-old patient scheduled for elective shoulder surgery.
  13. ncbi Sequential cloud-point extraction for toxicological screening analysis of medicaments in human plasma by high pressure liquid chromatography with diode array detector
    Katarzyna Madej
    Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Ingarden St 3, 30 060 Krakow, Poland Electronic address
    J Chromatogr A 1312:42-8. 2013
    ..Eight model drugs (paracetamol, promazine, chlorpromazine, amitriptyline, salicyclic acid, opipramol, alprazolam and carbamazepine) were chosen for the study of optimal CPE conditions...
  14. ncbi Anti-proliferative activity of haloperidol in B16 mouse and human SK-MEL-28 melanoma cell lines
    Jardena Nordenberg
    Endocrinology Laboratory, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
    Int J Oncol 27:1097-103. 2005
    ..The potency order was: haloperidol, reduced-haloperidol, ifenprodil tartrate, opipramol and carbetapentane citrate. B16 COL/R cells were to some extent, less sensitive to sigma ligands...
  15. ncbi Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach
    H Kirchherr
    Medical Laboratory Bremen, Haferwende 12, D 28359 Bremen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 843:100-13. 2006
    ..moclobemide, norclomipramine, nordoxepin, norfluoxetine, nortriptyline, O-desmethylvenlafaxine, olanzapine, opipramol, paroxetine, perazine, perphenazine, pimozide, pipamperone, quetiapine, reboxetine, risperidone, sertraline, ..
  16. ncbi Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression
    Fady Rachid
    Division of Adult Psychiatry, University Hospitals of Geneva, Switzerland
    World J Biol Psychiatry 7:261-4. 2006
    ..Therefore, caution should be exercised among clinicians using this experimental procedure, particularly in the treatment of bipolar depressed patients...
  17. ncbi Frequency of different anti-depressants associated with suicides and drug deaths
    Gustav Drasch
    Institute of Forensic Medicine, Ludwig Maximilians University, Nubbaumstr 26, D 80336 Munich, Germany
    Int J Legal Med 122:115-21. 2008
    ..In contrast, in cases with citalopram or opipramol, violent forms of suicides were significantly over-represented...
  18. ncbi [Generalized anxiety disorder (GAD)--diagnosis and therapy]
    Reinhard J Boerner
    Klinik für Psychiatrie und Psychotherapie CKQ, Zentrum für integrative Diagnostik und Therapie von Angsterkrankungen ZIDTA, Akademisches Lehrkrankenhaus der MHH, Quakenbrück
    Med Monatsschr Pharm 30:401-8; quiz 409-10. 2007
    ..The pharmacotherapy with SSRI, SNRI, opipramol, buspirone and pregabalin allows an effective treatment...
  19. ncbi [Pathologic worry]
    Reinhard J Boerner
    Klinik für Psychiatrie und Psychotherapie CKQ, Zentrum für integrative Diagnostik u Therapie von Angsterkrankungen ZIDTA, Quakenbrück
    MMW Fortschr Med 149:46-9; quiz 50. 2007
    ..In the pharmacotherapy SSRI and SNRI are the first line, but also Buspiron, Opipramol and Pregabalin are possible agents in the short-term and long-term therapy...
  20. ncbi Opipramol improves subjective quality of sleep the night prior to surgery: confirmatory testing of a double-blind, randomized clinical trial
    Michael Hueppe
    Department of Anaesthesiology, University of Luebeck, Luebeck, Germany
    Neuropsychobiology 64:24-31. 2011
    Due to its pharmacological properties, opipramol may be useful in the context of evening premedication in anaesthesiology...
  21. ncbi Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease
    Agnes A Luty
    Neuroscience Research Australia, Randwick, Sydney, New South Wales, Australia
    Ann Neurol 68:639-49. 2010
    ..Our objective was to identify the causative gene in an FTLD-MND pedigree with no mutations in known dementia genes...
  22. ncbi In vitro studies of DNA damage caused by tricyclic antidepressants: a role of peroxidase in the side effects of the drugs
    Ekaterina A Korobkova
    Science Department, John Jay College of Criminlal Justice, 445 W 59th Avenue, New York, New York 10019, USA
    Chem Res Toxicol 23:1497-503. 2010
    ..in vitro studies of the DNA damage caused by four tricyclic antidepressants: imipramine, amitriptyline, opipramol, and protriptyline. We focused particularly on the DNA damage aided by peroxidases...
  23. ncbi Determination of the chemical structure of potential organic impurities occurring in the drug substance opipramol
    E Luboch
    Department of Chemical Technology, Chemical Faculty, Gdansk University of Technology, Gdansk, Poland
    Pharmazie 65:239-44. 2010
    The tricyclic antipsychotic and antidepressant drug opipramol (opipramole) was examined with regard to the chemical structure of its organic impurities...
  24. ncbi Gastroprotective and antioxidant effects of opipramol on indomethacin-induced ulcers in rats
    Hakan Dursun
    Ataturk University, Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, Erzurum, Turkey
    Yakugaku Zasshi 129:861-9. 2009
    ..antiulcer effects, but there are presently no data in the literature specifically concerning the antidepressant opipramol. This study aimed to investigate the antiulcer effects of opipramol and to determine its potential relationship ..
  25. pmc The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism
    Melanie A Paquette
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Psychopharmacology (Berl) 204:743-54. 2009
    ..In the 6-hydroxydopamine (6-OHDA) rat model of PD, L-DOPA induces a similar phenomenon, which has been termed abnormal involuntary movement (AIM). We previously demonstrated that BMY-14802 suppresses AIM expression in this model...
  26. ncbi Binding of imipramine, dosulepin, and opipramol to liposomes for overdose treatment
    Brett A Howell
    Department of Chemical Engineering, University of Florida, Gainesville, Florida 32611, USA
    J Pharm Sci 98:3718-29. 2009
    ..were investigated as detoxifying agents for the weak bases imipramine and dosulepin and the diprotic drug opipramol. In vitro binding measurements in the presence of human serum samples revealed that the liposomes reduced the ..
  27. ncbi sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons
    Yelenis Herrera
    Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL 33612 4799, USA
    J Pharmacol Exp Ther 327:491-502. 2008
    ..The pan-selective sigma-1/sigma-2 receptor agonists, 1,3-di-o-tolyl-guanidine (100 microM) and opipramol (10 microM), reversibly decreased acid-induced elevations in [Ca2+](i) and membrane currents...
  28. ncbi Clinical trials with sigma ligands
    H P Volz
    Krankenhaus für Psychiatrie und Psychotherapie Schloss Werneck, Balthasar Neumann Platz 1, D 97440 Werneck, Germany
    Pharmacopsychiatry 37:S214-20. 2004
    ..in human studies in functional diarrhea as a model of somatoform disorder (igmesine), depression (igmesine, opipramol), anxiety (opipramol and--in animal models--siramisine), schizophrenia (panamasine, SL 82...
  29. ncbi [Somatoform disorders--what must the general practitioner know?]
    Hans Peter Volz
    Krankenhaus für Psychiatrie und Psychotherapie, Schloss Werneck
    MMW Fortschr Med 146:27-8, 30. 2004
    ..addition to a psychotherapeutic intervention or psychodynamic treatment or behavioral treatment, we now have the first positive results of a psychopharmacological treatment regimen with opipramol and the St. John's Wort extract LI 160.
  30. ncbi Identification and determination of opipramol metabolites in plasma and urine
    M Lappenberg-Pelzer
    Department of Clinical Toxicology and Pharmacology, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Berlin, Germany
    J Anal Toxicol 22:215-9. 1998
    In six cases of suspected opipramol overdose, commercially available immunoassays for tricyclic antidepressants (TCA) EMIT tox serum Assay and ADxR serum TCA Assay indicated arbitrarily high or toxic TCA concentrations...
  31. ncbi Chromatographic analysis (TLC) of fluoxetine, doxepine, imipramine and opipramol in human plasma
    G Misztal
    Department of Medicinal Chemistry, School of Medicine, Lublin, Poland
    Acta Pol Pharm 54:257-9. 1997
    Fluoxetine, imipramine, doxepine and opipramol after liquid-liquid extraction were separated by TLC on silica gel 60 GF254 by ascending and horizontal technique using suitable mobile phases...
  32. ncbi Some behavioral effects of 1,3-di-o-tolylguanidine, opipramol and sertraline, the sigma site ligands
    J Maj
    Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Pol J Pharmacol 48:379-95. 1996
    1,3-Di-o-tolylguanidine (DTG), opipramol (OPI) and sertraline (SER), sigma site ligands, were studied in Wistar rats and Albino Swiss mice, mainly with regard to their interaction with dopamine drugs...
  33. ncbi Fatal poisoning with the antidepressive agent opipramol
    G Skopp
    Institute of Legal Medicine, Ruprecht Karls University Heidelberg, Germany
    Forensic Sci Int 77:45-51. 1996
    An ingestion of an unknown quantity ( < or = 3000 mg) of opipramol dihydrochloride in a suicide case is described...
  34. ncbi Purification and amino-terminal sequencing of the high affinity phenylalkylamine Ca2+ antagonist binding protein from guinea pig liver endoplasmic reticulum
    F F Moebius
    Institut fur Biochemische Pharmakologie, Universitat Innsbruck, Austria
    J Biol Chem 269:29314-20. 1994
    ..The purified protein retained its high affinity for the antiischemic drugs emopamil (Kd = 4 nM), opipramol (IC50 = 15 nM), trifluoperazine (IC50 = 2 nM), and for Zn2+ (IC50 = 2 microM)...
  35. ncbi Tricyclic antidepressants and dextromethorphan bind with higher affinity to the phencyclidine receptor in the absence of magnesium and L-glutamate
    M A Sills
    Research Department, CIBA GEIGY Pharmaceutical Corp, Summit, New Jersey 07901
    Mol Pharmacol 36:160-5. 1989
    ..The TCAs imipramine, amitriptyline, and opipramol produced shallow inhibition curves in the absence of Mg2+ and L-GLU...
  36. ncbi High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents
    M Klein
    Department of Pharmacology, New York University Medical Center, NY 10016
    J Pharmacol Exp Ther 251:207-15. 1989
    ..The antidepressant opipramol and the benzomorphan (+)2'methoxyphenazocine were the most effective drugs tested, with Ki values of 0.4 nM...
  37. ncbi Some central effects of opipramol given repeatedly
    G Skuza
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Pol J Pharmacol Pharm 42:425-31. 1990
    Some central effects of opipramol administered repeatedly (twice daily, 14 days) were studied in rats and mice. Repeated or acute treatment with opipramol did not change the locomotor activity of rats...
  38. ncbi Opipramol, a potent sigma ligand, is an anti-ischemic agent: neurochemical evidence for an interaction with the N-methyl-D-aspartate receptor complex in vivo by cerebellar cGMP measurements
    T S Rao
    CNS Diseases Research, G D Searle and Co, Monsanto Company, St Louis, Missouri 63198
    Neuropharmacology 29:1199-204. 1990
    b>Opipramol, a potent sigma ligand and a tricyclic antidepressant compound, provided significant neuronal protection (P less than 0...
  39. ncbi [3H]opipramol labels a novel binding site and sigma receptors in rat brain membranes
    C D Ferris
    Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, Maryland 21205
    Mol Pharmacol 39:199-204. 1991
    b>Opipramol (OP), a clinically effective antidepressant with a tricyclic structure, is inactive as an inhibitor of biogenic amine uptake...
  40. ncbi Hepatitis caused by antidepressive therapy with maprotiline and opipramol
    J S Braun
    Department of Psychiatry and Psychotherapy, Albert Ludwigs University of Freiburg, Germany
    Pharmacopsychiatry 31:152-5. 1998
    ..developed severe laboratory abnormalities and clinical symptoms during therapy with maprotiline (Ludiomil) and opipramol (Insidon)...
  41. ncbi Opipramol for the treatment of somatoform disorders results from a placebo-controlled trial
    H P Volz
    Psychiatric Department, Friedrich Schiller Universitat Jena, Philosophenweg 3, D 07740, Jena, Germany
    Eur Neuropsychopharmacol 10:211-7. 2000
    Although somatoform disorders are highly prevalent, so far there is no established pharmacological treatment. Opipramol is a psychopharmacon widely prescribed in Germany...
  42. ncbi Urine sample preparation of tricyclic antidepressants by means of a supported liquid membrane technique for high-performance liquid chromatographic analysis
    J Trocewicz
    Department of Chemical Physics, Faculty of Chemistry, M Curie Sklodowska University, 20 031 Lublin, Poland
    J Chromatogr B Analyt Technol Biomed Life Sci 801:213-20. 2004
    ..The studied antidepressant drugs were amitriptyline, opipramol, noxiptyline and additionally diethazine was used as possible internal standard...
  43. ncbi Specific modulation of sigma binding sites by the anxiolytic drug opipramol
    G Holoubek
    Department of Pharmacology, Biocenter University Frankfurt, Frankfurt, Germany
    J Neural Transm 110:1169-79. 2003
    The atypical anxiolytic and antidepressive drug opipramol binds with high affinity to sigma1 and somewhat lower affinity to sigma2 sites. After subchronic treatment, opipramol significantly down-regulated sigma2 but not sigma1 sites...
  44. ncbi Bioavailability of opipramol from a film-coated tablet, a sugar-coated tablet and an aqueous solution in healthy volunteers
    Frieder Kees
    Department of Pharmacology, University of Regensburg, Regensburg, Germany
    Arzneimittelforschung 53:87-92. 2003
    b>Opipramol (4-[3-(5H-dibenz[b,f]-azepine-5-yl)-propyl]-1-piperazine-ethanol dihydrochloride, CAS 315-72-0) is regarded as an anxiolytic compound with antidepressant properties, and it is one of the most frequently prescribed psychotropic ..
  45. ncbi The treatment of generalised anxiety disorder. A systematic review
    C K Gale
    South Auckland Clinical School and Division of Psychiatry, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    Panminerva Med 44:283-6. 2002
    ..Cognitive therapy, anxiety management therapy, certain antidepressants (paroxetine, imipramine, trazodone, opipramol), benzodiazeines and buspirone are effective treatments for GAD...
  46. ncbi Effects of opipramol as an evening anaesthesiologic premedication
    Klaus Gerlach
    University of Lubeck, Department of Anaesthesiology and Intensive Care Medicine, Lubeck, Germany
    Neuropsychobiology 46:161-6. 2002
    To date, opipramol has not been examined within the context of evening premedication in anaesthesiology. A suitable drug for such an application should induce anxiolytic and sleep-favouring effects...
  47. ncbi Simultaneous determination of seven tricyclic antidepressant drugs in human plasma by direct-injection HPLC-APCI-MS-MS with an ion trap detector
    Manfred Kollroser
    Institute of Forensic Medicine, Karl Franzens University Graz, Graz, Austria
    Ther Drug Monit 24:537-44. 2002
    ..quantitation of seven tricyclic antidepressants-amitriptyline, nortriptyline, doxepin, dosulepin, dibenzepin, opipramol, and melitracen-in human plasma. After the addition of the internal standard lofepramine and dilution with 0...
  48. ncbi Determination of opipramol in human plasma by high-performance liquid chromatography with photometric detection using a cyanopropyl column
    F Kees
    Department of Pharmacology, University of Regensburg, Germany
    J Chromatogr B Biomed Sci Appl 753:337-42. 2001
    A high-performance liquid chromatographic method is described for the determination of opipramol in human plasma. Opipramol was extracted into tert.-butylmethyl ether, separated on a cyanopropyl silica column and detected at 254 nm...
  49. ncbi Opipramol for the treatment of generalized anxiety disorder: a placebo-controlled trial including an alprazolam-treated group
    H J Moller
    Psychiatrische Klinik der Ludwig Maximilians Universität, Munich, Germany
    J Clin Psychopharmacol 21:59-65. 2001
    b>Opipramol, a drug widely prescribed in Germany, is a tricyclic compound with no reuptake-inhibiting properties. However, it has pronounced D2-, 5-HT2-, and H1-blocking potential and high affinity to sigma receptors (sigma-1 and sigma-2)...
  50. ncbi [Drug rebound headaches]
    A Prusinski
    Katedry i Kliniki Neurologii AM w Lodzi
    Neurol Neurochir Pol 32:31-7. 1999
    ..Antidepressants are given for their alleviation. The author prescribes opipramol /Pramolan/ which is taken by increments from half tablet up to three in 6 days and the treatment is then ..
  51. pmc [(3)H]-trimetazidine mitochondrial binding sites: regulation by cations, effect of trimetazidine derivatives and other agents and interaction with an endogenous substance
    D Morin
    Departement de Pharmacologie, Faculté de Médecine de Paris XII, F 94010 Creteil, France
    Br J Pharmacol 130:655-63. 2000
    ..Among the drugs tested pentazocine, ifenprodil, opipramol, perphenazine, haloperidol, and to a lower extent prenylamine, carbetapentane and dextromethorphan competed with ..
  52. ncbi A case of 'auto-immune thrombocytopenic purpura' serologically similar to post-transfusion purpura
    E Taaning
    Department of Clinical Immunology and Blood Bank, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Vox Sang 62:108-12. 1992
    ..However, the present patient had no history of blood transfusion prior to the unset of purpura and the thrombocytopenia had persisted 6 months before splenectomy...

Research Grants1

  1. Expanding the therapeutic window for stroke treatment.
    KEITH PENNYPACKER; Fiscal Year: 2009
    ..Moreover, we will test the sigma receptor ligand opipramol in our stroke model...