Genomes and Genes
Summary: An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.
Publications325 found, 100 shown here
- Carbamazepine--the commonest cause of toxic epidermal necrolysis and Stevens-Johnson syndrome: a study of 7 yearsK Devi
Department of Skin and VD, Medical College, Kottayam, India
Indian J Dermatol Venereol Leprol 71:325-8. 2005..The drugs commonly implicated as the cause of these drug reactions vary depending on host factors and the prescription pattern of drugs in that particular area...
- Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among IndiansTimir Y Mehta
Dr Rasiklal Shah Sarvajanik Hospital, Modasa 383315, India
Indian J Dermatol Venereol Leprol 75:579-82. 2009..and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced ..
- HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in EuropeansMark McCormack
Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
N Engl J Med 364:1134-43. 2011b>Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions...
- Carbamazepine-induced toxic effects and HLA-B*1502 screening in TaiwanPei Chen
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
N Engl J Med 364:1126-33. 2011b>Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), in Southeast Asian countries...
- Accounting for the solubility-permeability interplay in oral formulation development for poor water solubility drugs: the effect of PEG-400 on carbamazepine absorptionAvital Beig
Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Eur J Pharm Biopharm 81:386-91. 2012..The apparent solubility of the lipophilic drug carbamazepine was measured in systems containing various levels of the co-solvent PEG-400...
- Removal of pharmaceuticals and fragrances in biological wastewater treatmentAdriano Joss
Eawag, Ueberlandstr 133, 8600 Dubendorf, Switzerland
Water Res 39:3139-52. 2005..removal of pharmaceuticals was mainly due to biological transformation and varied from insignificant (<10%, carbamazepine) to>90% (ibuprofen)...
- Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosingS G Leckband
Veterans Affairs San Diego Healthcare System, San Diego, California, USA
Clin Pharmacol Ther 94:324-8. 2013..with an increased risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in response to carbamazepine treatment...
- Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapyJinsook Kim
Interdisciplinary Program in Neuroscience, Georgetown University, W215 Research Building, 3970 Reservoir Road, N W, Washington, DC 20057, USA
J Pharmacol Exp Ther 323:165-73. 2007The aim of this study was to test the potential neurotoxicity of three antiepileptic drugs (AEDs), carbamazepine (5H-dibenzepine-5-carboxamide), topiramate [2,3:4,5-bis-O-(1-methylethylidene)-beta-d-fructopyranose sulfamate], and ..
- Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese populationTakeshi Ozeki
Research Group for Pharmacogenomics, RIKEN Center for Genomic Medicine, Yokohama 230 0045, Japan
Hum Mol Genet 20:1034-41. 2011An anticonvulsant, carbamazepine (CBZ), is known to show incidences of cutaneous adverse drug reactions (cADRs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS)...
- ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patientsTakayuki Seo
Kumamoto University, Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Oe honmachi 5 1, Kumamoto 862 0973, Japan
Pharmacogenomics 7:551-61. 2006..Our objective was to investigate the effect of ABCB1 polymorphisms on AED responsiveness and on the pharmacokinetics of carbamazepine (CBZ) in epileptic patients with the indication for CBZ therapy.
- Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndromeChun Yu Wei
Molecular Medicine Program, Taiwan International Graduate Program, Taipei, Taiwan
J Allergy Clin Immunol 129:1562-9.e5. 2012..Increasing studies have revealed that HLA alleles are the major genetic determinants of drug hypersensitivity; however, the underlying molecular mechanism remains unclear...
- A common mechanism of action for three mood-stabilizing drugsRobin S B Williams
Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
Nature 417:292-5. 2002Lithium, carbamazepine and valproic acid are effective mood-stabilizing treatments for bipolar affective disorder. The molecular mechanisms underlying the actions of these drugs and the illness itself are unknown...
- Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoinSarah K Tate
Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 102:5507-12. 2005Phenytoin and carbamazepine are effective and inexpensive anti-epileptic drugs (AEDs). As with many AEDs, a broad range of doses is used, with the final "maintenance" dose normally determined by trial and error...
- The effect of carbamazepine on human corticomuscular coherenceC Nicholas Riddle
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK
Neuroimage 22:333-40. 2004..has recently been reported in a group of epileptic patients, all of whom were taking the anticonvulsant drug carbamazepine (CBZ)...
- HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patientsNahoko Kaniwa
Division of Medicinal Safety Sciences, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
Epilepsia 51:2461-5. 2010..Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients...
- Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han ChineseShuen Iu Hung
Institute of Biomedical Sciences, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 11529, Taiwan
Pharmacogenomics 11:349-56. 2010..We previously reported that carbamazepine (CBZ)-SJS/TEN is strongly associated with the HLA-B*1502 in Han Chinese, which has been confirmed in other ..
- Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in KoreansSae Hoon Kim
Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea
Epilepsy Res 97:190-7. 2011Although the US FDA recommends screening for HLA-B*1502 allele in most of Asian ancestry before initiating carbamazepine therapy, the HLA associations with carbamazepine hypersensitivity in non-Chinese Asian populations remain unclear...
- Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han ChineseCeleste B L Man
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 48:1015-8. 2007A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-..
- 1-Methyl-1,2,3,4-tetrahydroisoquinoline enhances the anticonvulsant action of carbamazepine and valproate in the mouse maximal electroshock seizure modelJarogniew J Luszczki
Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
Neuropharmacology 50:133-42. 2006..001). Similarly, 1-MeTHIQ (at 10 mg/kg) enhanced the antielectroshock activity of carbamazepine (CBZ) in mice, decreasing its ED50 from 10.8 to 7.8 mg/kg (P < 0.05)...
- Toxic effects and bioaccumulation of carbamazepine evaluated by biomarkers measured in organisms of different trophic levelsGabrielle Vernouillet
Department of Biological Sciences TOXEN, Université de Québec à Montréal, Succ Centre Ville, Montreal, Quebec, Canada
Chemosphere 80:1062-8. 2010..platyurus and H. attenuata suggesting that redox activity of the lipophilic CBZ was at play. This study highlighted the processes of carbamazepine toxicity transfer between trophic levels in aquatic organisms.
- Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouseCatharina Lavebratt
Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska Hospital L8 00, 171 76 Stockholm, Sweden
Neurobiol Dis 24:374-83. 2006b>Carbamazepine (CBZ) is a commonly used antiepileptic drug known to block voltage-gated sodium channels. Infants exposed to CBZ in utero show reduced head circumference, for reasons unknown...
- Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patientsSandeep Grover
Institute of Genomics and Integrative Biology IGIB, Council of Scientific and Industrial Research CSIR, Mall Road, Delhi 110 007, India
Biochimie 92:1207-12. 2010..C3435T in determining drug response to first line antiepileptic drugs (AEDs) namely phenobarbitone, phenytoin, carbamazepine and valproate in North Indian cohort of epilepsy patients...
- Effect of carbamazepine and oxcarbazepine on wild-type and mutant neuronal nicotinic acetylcholine receptors linked to nocturnal frontal lobe epilepsyChiara Di Resta
Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
Eur J Pharmacol 643:13-20. 2010b>Carbamazepine (5H-dibenz[b,f]azepine-5-carboxamide) and oxcarbazepine (10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide) are widely used for the treatment of partial epilepsy...
- The mechanism of carbamazepine aggravation of absence seizuresLige Liu
Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Royal Parade, Parkville 3050, Victoria, Australia
J Pharmacol Exp Ther 319:790-8. 2006b>Carbamazepine (CBZ) aggravates many generalized seizures types, particularly absence seizures, but the mechanisms underlying this are poorly understood...
- A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsyWon Joo Kim
Departments of Pharmacology, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, 134 Sinchon dong, Seoul, Korea
Pharmacogenet Genomics 20:249-56. 2010..Therefore, genetic variations in the MRP2 gene may affect individual drug responses to the antiepileptic agent carbamazepine.
- Physiological condition status and muscle-based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepineZhi Hua Li
Research Institute of Fish Culture and Hydrobiology, University of South Bohemia Ceske Budejovice, Zatisi 728 II, 398 25 Vodnany, Czech Republic
J Appl Toxicol 30:197-203. 2010..In this study, the chronic toxic effects of carbamazepine (CBZ), an anticonvulsant pharmaceutical commonly present in surface and ground water, on physiological ..
- Effects of carbamazepine and amitriptyline on tetrodotoxinresistant Na+ channels in immature rat trigeminal ganglion neuronsYun Kyung Hur
Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 700 412, Korea
Arch Pharm Res 31:178-82. 2008..Here we report the effects of carbamazepine (CBZ) and amitriptyline (ATL) on tetrodotoxin-resistant (TTX-R) Na' channels expressed on immature rat TG ..
- Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of Carbamazepine in wastewater treatment and during groundwater infiltrationM Clara
Institute for Water Quality and Waste Management, Vienna University of Technology, A 1040 Vienna, Karlsplatz 13 226, Austria
Water Res 38:947-54. 2004..sources of pharmaceutical residues in surface waters, where high concentrations of the antiepileptic drug Carbamazepine have been detected. The solids retention time (SRT) is the most important parameter for the design of STPs...
- Antiepileptic drugs as human teratogensMervyn J Eadie
University of Queensland, and Royal Brisbane and Women s Hospital, Herston, Brisbane, Australia 4029, Australia
Expert Opin Drug Saf 7:195-209. 2008..There is still uncertainty concerning the risk of fetal malformation associated with the intake of various individual antiepileptic drugs in pregnant women...
- Normal intelligence in children with prenatal exposure to carbamazepineE Gaily
Hospital for Children and Adolescents, 00029 HUS, Finland
Neurology 62:28-32. 2004To investigate the effect of antiepileptic drugs, especially carbamazepine and valproate, on intelligence in prenatally exposed children of mothers with epilepsy.
- HLA-B*1502-bound peptides: implications for the pathogenesis of carbamazepine-induced Stevens-Johnson syndromeChih Wen Ou Yang
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
J Allergy Clin Immunol 120:870-7. 2007..HLA-B(*)1502 tightly associated with carbamazepine (CBZ) induced these conditions in a Han Chinese population.
- Fate and mobility of pharmaceuticals in solid matricesPanagiota Drillia
Department of Chemical Engineering, University of Patras, Karatheodori 1, 26500 Patras, Greece
Chemosphere 60:1034-44. 2005..The pharmaceuticals examined were carbamazepine, propranolol, diclofenac sodium, clofibric acid, sulfamethoxazole and ofloxacin...
- Clinical pharmacokinetics of oxcarbazepineTheodor W May
Department of Biochemistry, Epilepsy Research Foundation, Bielefeld, Germany
Clin Pharmacokinet 42:1023-42. 2003Oxcarbazepine is an antiepileptic drug with a chemical structure similar to carbamazepine, but with different metabolism...
- Model-based approach to characterize efavirenz autoinduction and concurrent enzyme induction with carbamazepineMin Zhu
Research and Development, Bristol Myers Squibb, P O Box 4000, Princeton, NJ 08543 4000, USA
Antimicrob Agents Chemother 53:2346-53. 2009..interaction model was developed to quantify efavirenz autoinduction and further induction with concurrent carbamazepine coadministration...
- Prospective assessment of levetiracetam pharmacokinetics during dose escalation in 4- to 12-year-old children with partial-onset seizures on concomitant carbamazepine or valproateNathan B Fountain
F E Dreifuss Comprehensive Epilepsy Program, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Epilepsy Res 74:60-9. 2007..metabolite ucb L057 in children with partial-onset seizures and determine whether it is affected by adjunctive carbamazepine or valproate...
- Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in KoreaYoungHee Kim
School of Public Health, Seoul National University, Seoul, Republic of Korea
Environ Int 33:370-5. 2007..In this study, the four most abundantly used pharmaceuticals in Korea, namely acetaminophen, carbamazepine, cimetidine, and diltiazem, and six sulfonamide related antibiotics, including sulfamethoxazole, ..
- Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acidHamza Karabiber
Kahramanmaras Sutcuimam Universitesi, Tip Fakultesi, Pediatri Anabilim Dalý 46050, Kahramanmaras, Turkey
Brain Dev 25:113-5. 2003..The aim of this study is to investigate the effect of valproate (VA) and carbamazepine (CBZ) on the serum levels of HMC, B12, and FA...
- Increased bone turnover in prepubertal, pubertal, and postpubertal patients receiving carbamazepineAlberto Verrotti
Department of Medicine, Section of Pediatrics, University of Chieti, Italy
Epilepsia 43:1488-92. 2002To study the markers of bone turnover in epilepsy patients in the different stages of the pubertal growth before and after the beginning of carbamazepine (CBZ) monotherapy.
- Characterization of interaction and the effect of carbamazepine on the structure of human serum albuminShankara S Kalanur
Department of Chemistry, Karnatak University, Dharwad 580 003, India
J Pharm Biomed Anal 53:660-6. 2010The binding of carbamazepine (CBZ) to human serum albumin (HSA) was investigated under simulative physiological conditions. In this study, intrinsic fluorescence of tryptophan-214 in HSA was monitored upon the addition of CBZ...
- Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered ratsK H Reeta
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India
Eur J Pharmacol 644:106-12. 2010The antiepileptic drugs, phenobarbitone and carbamazepine are well known to cause cognitive impairment on chronic use...
- Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central ChinaX T Wu
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
Epilepsy Behav 19:405-8. 2010The aim of this study was to investigate the association between carbamazepine (CBZ)-induced cutaneous adverse drug reactions (cADRs) and the HLA-B*1502 allele among patients from central China...
- Lamotrigine for trigeminal neuralgia: efficacy and safety in comparison with carbamazepineSameer Shaikh
Department of Oral Medicine and Oral Pathology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
J Chin Med Assoc 74:243-9. 2011..In this study, we evaluated the efficacy and occurrence of side effects of lamotrigine (LTG) in comparison with carbamazepine (CBZ), in trigeminal neuralgia (TN) patients.
- Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024António F Ambrósio
Department of Cell Biology, Center for Neuroscience of Coimbra, Portugal
Neurochem Res 27:121-30. 2002b>Carbamazepine (CBZ) has been extensively used in the treatment of epilepsy, as well as in the treatment of neuropathic pain and affective disorders...
- Rocuronium-induced neuromuscular block is affected by chronic carbamazepine therapyA Spacek
Department of Anesthesia and General Intensive Care B, University of Vienna, Austria
Anesthesiology 90:109-12. 1999..This study investigated the influence of chronic carbamazepine therapy on the neuromuscular block induced by the new muscle relaxant rocuronium.
- Drug interaction and pharmacokinetic modeling of oxcarbazepine in korean patients with epilepsyKyoung Jin Park
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Clin Neuropharmacol 35:40-4. 2012....
- HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic reviewV L Yip
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
Clin Pharmacol Ther 92:757-65. 2012b>Carbamazepine (CBZ) therapy is associated with cutaneous adverse reactions in up to 10% of patients. Predisposition to these hypersensitivity reactions has been linked to the human leukocyte antigen (HLA) genotype...
- Zebrafish (Danio rerio) embryos as a model for testing proteratogensStefan Weigt
Institute of Toxicology, Merck KGaA, 64293 Darmstadt, Germany
Toxicology 281:25-36. 2011..and describes results obtained for 10 proteratogens: 2-acetylaminofluorene, benzo[a]pyrene, aflatoxin B(1), carbamazepine, phenytoin, trimethadione, cyclophosphamide, ifosfamide, tegafur and thio-TEPA...
- Eosinophilic leukemoid reaction associated with carbamazepine hypersensitivityGaurish Laad
Department of Skin and VD, Goa Medical College and Hospitals, Bambolim, Goa, India
Indian J Dermatol Venereol Leprol 71:35-7. 2005b>Carbamazepine is widely used in the treatment of epilepsy, neuralgic pain, and bipolar affective disorders...
- Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han populationFa Yun Hu
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
Seizure 20:160-2. 2011..In the present study, we conducted a pilot study to detect a possible association of oxcarbazepine (OXC)-induced MPE with HLA-B*1502 allele in Chinese Han population...
- Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsyHongmei Meng
The First Hospital of Jilin University, Changchun, People s Republic of China
Epilepsy Behav 21:27-30. 2011..We sought to investigate the effects of ABCB1 polymorphisms on plasma carbamazepine (CBZ) concentrations and pharmacoresistance in Chinese patients with epilepsy...
- Preparation of carbamazepine-Soluplus solid dispersions by hot-melt extrusion, and prediction of drug-polymer miscibility by thermodynamic model fittingJelena Djuriš
Department of Pharmaceutical Technology and Cosmetology, University of Belgrade, Belgrade, Serbia
Eur J Pharm Biopharm 84:228-37. 2013..The present study investigates the feasibility of forming solid dispersions of carbamazepine (CBZ) into polyethyleneglycol-polyvinyl caprolactam-polyvinyl acetate grafted copolymer (Soluplus) by hot-melt ..
- Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-β pathology in a mouse model of Alzheimer's diseaseLixi Li
Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
Curr Alzheimer Res 10:433-41. 2013..The aim of this study is to test if carbamazepine (CBZ), an anti-epileptic drug that has a potent autophagy enhancement effect, has anti-AD effects in APP(swe)/..
- Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock-induced seizures in ratsMonika Pahuja
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India
Epilepsy Behav 25:368-73. 2012..the pharmacokinetic and pharmacodynamic interactions of HEZJ with phenytoin (PHT), phenobarbitone (PB), and carbamazepine (CBZ) in maximal electroshock (MES)-induced seizures in male Wistar rats...
- Fish embryo toxicity of carbamazepine, diclofenac and metoprololEvert Jan van den Brandhof
Laboratory for Ecological Risk Assessment, RIVM, PO Box 1, Bilthoven 3720 BA, The Netherlands
Ecotoxicol Environ Saf 73:1862-6. 2010..In this FET test 2-h-old zebrafish embryos were exposed for 72 h to carbamazepine, diclofenac and metoprolol to observe effects on embryo mortality, gastrulation, somite formation, tail ..
- The comparative evaluation of gabapentin and carbamazepine for pain management in Guillain-Barré syndrome patients in the intensive care unitChandra Kant Pandey
Department of Anaesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
Anesth Analg 101:220-5, table of contents. 2005We evaluated the effects of gabapentin and carbamazepine for pain relief in 36 Guillain-Barré syndrome patients...
- In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulationBao Chen
School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
Int J Nanomedicine 7:199-209. 2012..With the aim of improving adsorption capacity and accordingly achieving high drug loading, ordered mesoporous silica with a high surface area and narrow pore size distribution was synthesized and used in a liquisolid formulation...
- Fecal coliforms, caffeine and carbamazepine in stormwater collection systems in a large urban areaSebastien Sauve
Departement de Chimie, Universite de Montreal, Montreal, QC, Canada
Chemosphere 86:118-23. 2012..storm sewer outfall pipes that collect storm waters across the Island of Montréal were analyzed for caffeine, carbamazepine and fecal coliforms...
- Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine)Yousef Javadzadeh
Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran
Int J Pharm 341:26-34. 2007Different liquisolid formulations of carbamazepine were accomplished by dissolving the drug in the non-toxic hydrophilic liquids, and adsorbing the solution onto the surface of silica...
- Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio)R Triebskorn
Steinbeis Transfer Center for Ecotoxicology and Ecophysiology, Blumenstr 13, 72108 Rottenburg, Germany
Anal Bioanal Chem 387:1405-16. 2007..potential effects of human pharmaceuticals in aquatic wildlife, laboratory experiments were conducted with carbamazepine, clofibric acid, metoprolol, and diclofenac using fish as test organisms...
- Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodiesYongjun Zhang
Department of Environmental Process Engineering, Institute of Environmental Technology, Technical University of Berlin, Strasse des 17 Juni 135, Berlin 10623, Germany
Chemosphere 73:1151-61. 2008In the aquatic environment, pharmaceuticals have been widely found. Among them, carbamazepine and diclofenac were detected at the highest frequency...
- Effects of pharmaceuticals on aquatic invertebrates. Part I. The antiepileptic drug carbamazepineM Oetken
Department of Ecology and Evolution Ecotoxicology, Johann Wolfgang Goethe University Frankfurt am Main, Siesmayerstrasse 70, Frankfurt, D 60054, Germany frankfurt de
Arch Environ Contam Toxicol 49:353-61. 2005The effects of the antiepileptic drug carbamazepine (CBZ) were studied in three freshwater invertebrate species representing different taxonomic groups, life histories, and habitats in aquatic ecosystems...
- Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control studyJanneke Jentink
Department of Pharmacoepidemiology and Pharmacoeconomics, Division of Pharmacy, University of Groningen, Netherlands
BMJ 341:c6581. 2010To identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy.
- Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviourJ J Idänpään-Heikkilä
The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
Pain 79:281-90. 1999..b>Carbamazepine was effective only after doses (> or =10 mg/kg s.c...
- Kinetic changes and modulation by carbamazepine on voltage-gated sodium channels in rat CA1 neurons after epilepsyGuang Chun Sun
Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098SM, The Netherlands
Acta Pharmacol Sin 27:1537-46. 2006To study whether the functional properties of sodium channels, and subsequently the channel modulation by carbamazepine (CBZ) in hippocampal CA1 neurons can be changed after epileptic seizures.
- P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brainH Potschka
Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, , D-30559 Hannover, Germany
Neuroreport 12:3557-60. 2001..In the present study, we used in vivo microdialysis in rats to study whether the concentration of carbamazepine in the extracellular fluid of the cerebral cortex can be enhanced by inhibition of PGP or MRP, using the PGP ..
- Differential efficacy of lithium and carbamazepine in the prophylaxis of bipolar disorder: results of the MAP studyN Kleindienst
Psychiatric Hospital of the University of Munich, Germany
Neuropsychobiology 42:2-10. 2000..5 years, the differential efficacy of lithium versus carbamazepine was compared in 171 bipolar patients (DSM-IV)...
- The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic childrenAli Aycicek
Sanliurfa Children s Hospital, Sanliurfa, Turkey
Eur Neurol 57:65-9. 2007..We studied the effect of antiepileptic monotherapy on serum level of total antioxidant capacity, lipid hydroperoxide, total peroxide, oxidative stress index, and individual serum antioxidants such as albumin, bilirubin and uric acid...
- Effects of carbamazepine on morphine-induced behavioral sensitization in miceJun Xu Li
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100083, PR China
Brain Res 1019:77-83. 2004Effects of carbamazepine on behavioral sensitization to morphine in mice has been investigated. Mice treated daily for 7 days with morphine (10 mg/kg) induced behavioral sensitization. Carbamazepine (10, 20, 40 mg/kg, i.p...
- Spatiotemporal distribution of pharmaceuticals in the Douro River estuary (Portugal)Tânia Vieira Madureira
Health Sciences Research Center of the Superior Institute Health Sciences North, Gandra, Paredes, Portugal
Sci Total Environ 408:5513-20. 2010..The maximum concentrations found were 178ng/L for carbamazepine, 3.65ng/L for diazepam, 70.3ng/L for fenofibric acid, 3.18ng/L for propranolol, 15...
- Increased antibody levels to desmogleins 1 and 3 after administration of carbamazepineT Yoshimura
Pharmaceutical Division, Ogaki Municipal Hospital, Ogaki, Japan
Clin Exp Dermatol 26:441-5. 2001..have been reported to occur in individuals after exposure to a variety of drugs, but pemphigus caused by carbamazepine is not common...
- Hyperhomocysteinemia in children treated with sodium valproate and carbamazepineA Verrotti
Department of Medicine, Section of Pediatrics, University of Chieti, Via dei Vestini 5, I 66100, Chieti, Italy
Epilepsy Res 41:253-7. 2000To evaluate plasma homocysteine (Hcy) concentrations in children receiving sodium valproate (VPA) and carbamazepine (CBZ), monotherapy, in comparison with healthy control subjects and to determine the possible relationship between Hcy ..
- A 6-month, multicenter, open-label evaluation of beaded, extended-release carbamazepine capsule monotherapy in bipolar disorder patients with manic or mixed episodesTerence A Ketter
Stanford University School of Medicine, Stanford, California 94305 5723, USA
J Clin Psychiatry 65:668-73. 2004b>Carbamazepine is frequently used for treating bipolar disorder, but few large trials have assessed its efficacy in preventing relapse...
- Comparison of the four anhydrous polymorphs of carbamazepine and the crystal structure of form IAdam L Grzesiak
Department of Chemistry and the Macromolecular Science and Engineering Program, The University of Michigan, Ann Arbor, Michigan 48109 1055, USA
J Pharm Sci 92:2260-71. 2003For decades, carbamazepine (CBZ) has served as a model compound for groups engaged in the study of crystal polymorphism...
- Model-based evaluation of reduction strategies for micropollutants from wastewater treatment plants in complex river networksChristoph Ort
Eawag, Swiss Federal Institute of Aquatic Science and Technology, CH 8600 Dubendorf, Switzerland
Environ Sci Technol 43:3214-20. 2009..At base flow conditions, carbamazepine concentrations (parent compound only) are ubiquitously below a water quality criterion of 0.5 microg L(-1)...
- Association between SCN1A polymorphism and carbamazepine-resistant epilepsyTomohide Abe
Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
Br J Clin Pharmacol 66:304-7. 2008To establish whether the SCN1A IVS5-91 G > A polymorphism of the SCN1A gene, which encodes the neuronal sodium channel alpha subunit, affects responsiveness to the antiepileptic drugs (AEDS) carbamazepine and/or phenytoin.
- Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pigAlyson Fox
Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK
Pain 105:355-62. 2003..Oxcarbazepine and carbamazepine (3-100 mg x kg(-1)) did not affect mechanical hyperalgesia or tactile allodynia induced by partial sciatic ..
- Carbamazepine for prevention of oxaliplatin-related neurotoxicity in patients with advanced colorectal cancer: final results of a randomised, controlled, multicenter phase II studyStefan von Delius
Department of Internal Medicine II, Technical University of Munich, Munich, Germany
Invest New Drugs 25:173-80. 2007Oxaliplatin-induced neurotoxicity is a growing, relevant clinical problem. In this study we evaluated the efficacy and safety of carbamazepine for prevention of oxaliplatin-associated neuropathy in patients with advanced colorectal cancer.
- Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamideJonathan W Theile
Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mol Pharmacol 80:724-34. 2011..Furthermore, pain associated with PEPD, but not IEM, is alleviated by the sodium channel inhibitor carbamazepine. We speculated that selective attenuation of PEPD-enhanced resurgent currents might contribute to this ..
- HLA class I markers in Japanese patients with carbamazepine-induced cutaneous adverse reactionsHiroko Ikeda
National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
Epilepsia 51:297-300. 2010b>Carbamazepine (CBZ) is frequently used for treating epilepsy, but this drug causes cutaneous adverse drug reactions (cADRs) that may range from mild to severe...
- Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin dispositionC Simon
Department of Neurology, University Hospital Zurich, Zurich, Switzerland
Acta Neurol Scand 115:232-42. 2007..absorption and bioavailability might contribute to inadequate control of seizures under treatment with carbamazepine and phenytoin...
- Carbamazepine is not a substrate for P-glycoproteinA Owen
Department of Pharmacology and Therapeutics, The University of Liverpool, L69 3GE, UK
Br J Clin Pharmacol 51:345-9. 2001AIMS: To determine whether the anticonvulsant carbamazepine (CBZ), a known CYP3A4 substrate, is also a substrate for the multidrug efflux transporter P-glycoprotein (Pgp)...
- Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from TurkeyGulay Oner Ozgon
Department of Genetics, Institute for Experimental Medical Research, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Eur Neurol 59:67-70. 2008We investigated the prevalence of this multidrug resistance 1 gene (MDR1) polymorphism in drug-responsive versus drug-resistant epilepsy patients treated with carbamazepine (CBZ), which is a substrate of this protein.
- The autophagy-inducing drug carbamazepine is a radiation protector and mitigatorHyun Kim
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Int J Radiat Biol 87:1052-60. 2011To determine whether Carbamazepine (CBZ) is a radiation protector and/or mitigator.
- Bipolar disorderBruno Muller-Oerlinghausen
Department of Psychiatry, Research Group of Clinical Psychopharmacology, Freie Universitat Berlin, Berlin
Lancet 359:241-7. 2002..They also possess well documented antisuicidal effects. Second choice prophylactic treatments are carbamazepine and valproate, although evidence of their effectiveness is weaker.
- A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgiaTanya Z Fischer
Department of Neurology, Yale University School of Medicine, New Haven, CT 16510, USA
Ann Neurol 65:733-41. 2009..Inherited erythromelalgia (IEM) has been linked to gain-of-function mutations of Na(v)1.7. We now report a novel mutation (V400M) in a three-generation Canadian family in which pain is relieved by carbamazepine (CBZ).
- Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactionsShuen Iu Hung
Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei, Taiwan
Pharmacogenet Genomics 16:297-306. 2006The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (..
- Extended release carbamazepine in the treatment of pathological gambling: an open-label studyDonald W Black
University of Iowa Roy J and Lucille A Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:1191-4. 2008The efficacy and tolerability of extended release carbamazepine was tested in the treatment of pathological gambling (PG).
- Carbamazepine and topiramate modulation of transient and persistent sodium currents studied in HEK293 cells expressing the Na(v)1.3 alpha-subunitGuang Chun Sun
Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
Epilepsia 48:774-82. 2007..The interactions of the AEDs carbamazepine (CBZ) and topiramate (TPM) with the persistent and transient Na(+) current were investigated.
- Dissolution rate improvement of poorly water-soluble drugs obtained by adsorbing solutions of drugs in hydrophilic solvents onto high surface area carriersHeike Friedrich
College of Pharmacy, Freie Universitat Berlin, Berlin, Germany
Eur J Pharm Biopharm 62:171-7. 2006The dissolution rate of the model drugs carbamazepine and nifedipine was improved by adsorbing solutions of the drugs in hydrophilic non-volatile or volatile solvents onto carriers with a large surface area...
- Stimulation of retinoic acid-induced functional sodium iodide symporter (NIS) expression and cytotoxicity of ¹³¹I by carbamazepine in breast cancer cellsMichael J Willhauck
Department of Internal Medicine II, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistrasse 15, 81377, Muenchen, Germany
Breast Cancer Res Treat 125:377-86. 2011..pregnane-X-receptor (PXR) forming a heterodimer with the retinoid-X-receptor (RXR), we examined the effect of carbamazepine (CBZ), a potent activator of PXR, on atRA-induced NIS expression and therapeutic efficacy of (131)I in MCF-7 ..
- The analysis of a group of acidic pharmaceuticals, carbamazepine, and potential endocrine disrupting compounds in wastewater irrigated soils by gas chromatography-mass spectrometryJuan C Durán-Álvarez
Instituto de Ingenieria, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, D F, Mexico
Talanta 78:1159-66. 2009..This article reports a method for a range of acidic pharmaceuticals, carbamazepine, and endocrine disrupting compounds in soils with final analysis by gas chromatography-mass spectrometry...
- Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai populationChaichon Locharernkul
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Epilepsia 49:2087-91. 2008Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations...
- Activation of T cells by carbamazepine and carbamazepine metabolitesYing Wu
Department of Pharmacology, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK
J Allergy Clin Immunol 118:233-41. 2006..T-cell-mediated hypersensitivity is a rare but serious manifestation of drug therapy...
- Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trialMadhur Gupta
Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
Epilepsia 45:1636-9. 2004..The study was designed to assess its effects on the blood levels of antioxidant enzymes in children with epilepsy receiving carbamazepine (CBZ).
- Treatment with carbamazepine and gabapentin of a patient with primary erythermalgia (erythromelalgia) identified to have a mutation in the SCN9A gene, encoding a voltage-gated sodium channelJ Natkunarajah
Department of Dermatology, St George s Hospital, London, UK
Clin Exp Dermatol 34:e640-2. 2009..We report a family identified to have a mutation in the SCN9A gene, in which one severely affected family member has responded to the therapeutic combination of gabapentin and carbamazepine treatment.
- Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methodsS Sethia
College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Int J Pharm 272:1-10. 2004This study compares the physicochemical properties of carbamazepine (CBZ) solid dispersions prepared by either a conventional solvent evaporation versus a supercritical fluid process...
- HLA-B locus in Caucasian patients with carbamazepine hypersensitivityAna Alfirevic
Department of Pharmacology and Therapeutics, The University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK
Pharmacogenomics 7:813-8. 2006A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS).
- Hypersensitivity syndrome induced by anticonvulsants: possible cross-reactivity between carbamazepine and lamotrigineKarim Aouam
Laboratoire de Pharmacologie, Faculte de medecine de Monastir, Rue Avicenne, 5019 Monastir, Tunisia
J Clin Pharmacol 49:1488-91. 2009A 14-year-old male presents with erythroderma and fever 44 days after carbamazepine intake. Laboratory exams show eosinophilia and elevated liver enzymes, and thoracic imaging reveals interstitial pneumonitis...
- Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patientsP W Park
Department of Laboratory Medicine, Gil Hospital, Gachon University, Incheon, Korea
J Clin Pharm Ther 34:569-74. 2009b>Carbamazepine (CBZ) is metabolized mainly by the CYP3A family of enzymes, which includes CYP3A4 and CYP3A5. Several studies have suggested that the CYP3A5*3 genotype influences the pharmacokinetics of CYP3A substrates...
- Drug-induced systemic lupus erythematosus after 7 years of treatment with carbamazepineLorenzo Pelizza
Psychiatric Operative Unit n 25 of Casalmaggiore Cremona, Oglio Po General Hospital, Italy
Acta Biomed 77:17-9. 2006Aim of this work is to describe a late-onset of carbamazepine-induced systemic lupus erythematosus (SLE) in a 38-year-old female patient who had been treated with daily carbamazepine (CBZ) for 7 years because of a bipolar I disorder...
- Effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemical epileptogenesis in ratsTarun Arora
Department of Pharmacology, University College of Medical Sciences, University of Delhi, Delhi, India
Basic Clin Pharmacol Toxicol 106:372-7. 2010The present study assessed the effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemically induced epileptogenesis in rats...
- Cellular Efflux and Metabolism of Protease InhibitorsAshim Mitra; Fiscal Year: 2004..will be first validated using model compound in each class: Tolbutamide - Class-A, Rhodamine 123 - Class-B, Carbamazepine - Class-C, and Cortisol - Class-D...
- Antiepileptogenic & Disease Modifying Effects of AEDsAsla Pitkanen; Fiscal Year: 2005..Aim of the present study is to investigate whether administration of 3 standard antiepileptic drugs (carbamazepine, valproate, levetiracetam) as monotherapy during epileptogenic phase (1) prevents the development of epilepsy, ..
- Trigeminal Neuropathic Pain MechanismsMichael Henry; Fiscal Year: 2006..channels following peripheral and central injury, since patients with trigeminal neuralgia usually respond to carbamazepine, while patients with peripheral trigeminal neuropathy rarely obtain significant relief with only carbamazepine...
- Patient-Derived Stem Cells for Phosphoproteomic Profiling NeuropsychopathologyDieter A Wolf; Fiscal Year: 2011..BPD, but, because of its side effects, anti-convulsants (including valproic acid, lamotrigine, topiramate &carbamazepine) &atypical anti-psychotics have also been prescribed...
- Role of the Unfolded Protein Response in Beta CellRandal J Kaufman; Fiscal Year: 2013..p cells that produce excessive proinsulin? We will test chemical chaperones, GLP-1, cyclosporin A, rapamycin/carbamazepine, etc...
- Carbamazepine for severe liver disease due to antitrypsin deficiencyDavid H Perlmutter; Fiscal Year: 2012..shown to enhance autophagic degradation of aggregation-prone proteins with polyglutamine repeats, we selected carbamazepine (CBZ) for detailed studies of its effect on ATZ because it has the most extensive safety profile in humans...
- Optimization of the FPI model for epilepsy therapy developmentRAIMONDO D'AMBROSIO; Fiscal Year: 2013..and generates CRSSs that are fully blocked by halothane, partially blocked by valproate, and very resistant to carbamazepine and carisbamate...
- Design and synthesis of novel anticonvulsant molecules.Rajesh Kumar Mishra; Fiscal Year: 2011..MB003), both exhibit lower ED50s than many other anti-convulsant drugs including valproic acid, felbamate, carbamazepine, phenytoin, and ethosuximide...
- The Effects of Antiepileptic Drugs on Serologic Indices of Vascular RiskScott Mintzer; Fiscal Year: 2012..Aim II: We will test the hypothesis that patients taking PHT or carbamazepine (CBZ) who are switched to a non-inducing AED will experience significant reductions in serum CRP and ..
- Drug brain biotransformation in human refractory epilepsyNicola Marchi; Fiscal Year: 2013..the BBB (and neurons) in human DRE brain;d) Overexpression of CYP3A4 in DRE EC is associated with exaggerated carbamazepine (CBZ) metabolism. This new metabolic pathway produces the toxic CBZ metabolite quinolic acid (QA)...
- Sodium Channel Gene Variation in the Treatment of EpilepsyKatherine D Holland; Fiscal Year: 2013..of this proposal is to determine the influence of genetic alterations in sodium channel genes on response to carbamazepine (CBZ), one of the main first line treatments for epilepsy...
- CHROMATOGRAPHIC AUTOMATION OF IMMUNOASSAYSDavid S Hage; Fiscal Year: 2013..immunoassays, as recently demonstrated for compounds such as warfarin, thyroxine, phenytoin and carbamazepine. Future studies will build on these previous efforts by considering new analytes and approaches that can be ..
- Therapeutic Use of Autophagy Enhancer Drugs for Alzheimer's DiseaseDavid H Perlmutter; Fiscal Year: 2012..In our recent work we have discovered that carbamazepine (CBZ), a drug that has been used for years as an anticonvulsant with a wide margin of safety, enhanced the ..
- Pilot PET Study Characterizing [1-11C] Arachadonic Acid in Bipolar DisorderM Elizabeth Sublette; Fiscal Year: 2013..In animal studies, mood stabilizers lithium, valproate, carbamazepine, and lamotrigine downregulate the brain AA cascade5...
- New therapies for liver fibrosis and hyperproliferation in alpha1-AT deficiencyDavid H Perlmutter; Fiscal Year: 2013..Perlmutter, Michalopoulos and Stolz showed that, by enhancing autophagic degradation of mutant ATZ, carbamazepine could reduce hepatic ATZ load and fibrosis in the PiZ mouse model of ATD, and therein provided evidence that ..
- EFFECTS OF ANTICONVULSANTS ON GLIAL ION TRANSPORTSteve White; Fiscal Year: 1991..be acutely and chronically exposed to therapeutic concentrations of the prototype anticonvulsants phenytoin, carbamazepine, valproate, diazepam, ethosuximide, acetazolamide, and to the calcium channel blocker flunarizine...
- Imaging the effect of centrotemporal spikes and seizures on language in childrenJennifer Vannest; Fiscal Year: 2013..The future double blind RCT will compare levetiracetam to carbamazepine (the current standard of care that does not eliminate CTS) in BECTS...
- LITHIUM IN AGGRESSIVE CHILDREN WITH CONDUCT DISORDERMagda Campbell; Fiscal Year: 1993..g.,POMS). Therefore alternate drugs have to be studied. The rationale for studying carbamazepine is twofold...
- Pharmacoresistance in rats with kainate-induced epilepsyF Dudek; Fiscal Year: 2005..to high doses of topiramate lasting several days? Are they resistant to similar treatments of carbamazepine, which is probably the most widely used AED? Are these rats pharmacoresistant to topiramate when it is used as ..
- PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPYTHOMAS FERRARO; Fiscal Year: 2003..ACD testing will involve dose-reponse studies with a panel of clinically relevant ACDs: phenytoin, carbamazepine, vaiproic acid and gamma-vinyl GABA...
- CARBAMAZEPINE IN THE TREATMENT OF COCAINE ABUSEJAMES HALIKAS; Fiscal Year: 1993..studies conducted by the University of Minnesota Chemical Dependency Treatment Program provide evidence that carbamazepine may be beneficial in the treatment of cocaine abuse...
- NEUROPHARMACOLOGY OF THE TRIGEMINAL NUCLEUSGERHARD FROMM; Fiscal Year: 1992b>Carbamazepine has become the drug of choice in the treatment of trigeminal neuralgia. However, it can have significant side effects as well as not being effective in some cases...
- VALPROATE VERSUS LITHIUM IN BIPOLAR RAPID CYCLINGJoseph Calabrese; Fiscal Year: 1999..Although controlled trials have demonstrated the efficacy of carbamazepine in the treatment of rapid-cycling bipolar disorder, the response to carbamazepine frequently deteriorates over ..
- INTELLIGENT REFRIGERATED AUTOMATIC STORAGE SYSTEMDAN CORNELL; Fiscal Year: 1993..This is a proposal for a random assignment, double-blind, placebo- controlled clinical trial of carbamazepine in 66 probable and possible AD outpatients with clinically significant behavioral disorders...
- CHEMICAL BASIS FOR DRUG TOXICITYMARJORIE HORNING; Fiscal Year: 1980Studies of epoxide formation from drugs (phenytoin and carbamazepine) and related compounds (naphthalene) with aromatic structures indicate that toxicity may be related to epoxide formation, and that diepoxides may be more toxic than ..
- ALTERING BEHAVIORAL RISK FOR DRUG DEPENDENCEDON CHEREK; Fiscal Year: 2001..disorder (ASPD), probably the highest risk population and (2) matched controls the drug to be employed are: carbamazepine, fenfluramine, methylphenidate and paroxetine...
- Early Randomized Surgical Epilepsy TrialJerome Engel; Fiscal Year: 2007..abstract_text> ..
- EPILEPSY CLINICAL RESEARCH PROGRAMIlo Leppik; Fiscal Year: 2006..The PK characteristics of carbamazepine (CBZ), valproic acid (VPA), lamotrigine (LTG), and topiramate (TPM) in elderly patients will be determined ..
- OXCARBAZEPINE--PREGNANCY AND INFANT OUTCOMEJOAN LOCKARD; Fiscal Year: 1999..b>Carbamazepine (CBZ: Tegretol) is the drug choice in temperol lobe epilepsy and has been used as an alternative to phenytoin-..
- PARENTERAL FORMULATION FOR CARBAMAZEPINEKERRY ESTES; Fiscal Year: 1991..Adapted from Applicant's Abstract) The favorable efficacy, toxicity and adverse side-effect profiles of carbamazepine (CBZ) contribute to its widespread and increasing use to control seizure in the epileptic patient...
- POLYTHERAPY MECHANISMS IN PREGNANCYJOAN LOCKARD; Fiscal Year: 1993..b>Carbamazepine (CBZ) apparently forms at least one reactive arene oxide metabolite, but no studies have been conducted to ..
- STUDIES RELEVANT TO RATIONAL ANTIEPILEPTIC THERAPYKENNETH DUDLEY; Fiscal Year: 1980Further refinements will be carried out on new gas chromatographic assays of valproic acid (VPA) and carbamazepine (CBZ) developed during year 01...
- CARBAMAZEPINE FORMULATION FOR IV EPILEPSY THERAPYMICHAEL VIOLANTE; Fiscal Year: 1993..No IV formulation exists for carbamazepine (CBZ), a drug of choice for epilepsy therapy...
- DEVELOPMENT OF PARENTERAL FORMULATION FOR CARBAMAZEPINEMarcus Brewster; Fiscal Year: 1993The favorable therapeutic profile of carbamazepine (CBZ) explains its widespread use in epileptic patients. However, no parenteral formulation is available for CBZ...
- Pharmacoresistance to AEDs during epileptogenesisHEIDI GRABENSTATTER; Fiscal Year: 2007..The dose effects of the traditional AED, carbamazepine, on spontaneous convulsive seizure activity will be tested late vs...
- GERIATRIC MENTAL HEALTH ACADEMIC AWARDPierre Tariot; Fiscal Year: 1992..The second is symptomatic pharmacotherapy, pursued by the study of the symptomatic benefit of carbamazepine and deprenyl in patients with dementia...
- Bipolar Statistical Summit:Methodologies to Advance Long Term Intervention TrialsCharles Bowden; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Neurodevelopmental Effects of Antiepileptic Drugs IIKimford Meador; Fiscal Year: 2009..in terms of their children's neurobehavioral development after in utero exposure to AED monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate)...
- PROGESTERONE THERAPY FOR WOMEN WITH EPILEPSYAndrew Herzog; Fiscal Year: 2008..30 x .35) 100,000 women with catamenial epilepsy and perhaps many more women with no a priori demonstrated hormonal sensitivity to seizure occurrence. ..
- CLINICAL PHARMACOLOGY OF CHILDHOOD EPILEPSYTracy Glauser; Fiscal Year: 2003....
- Blood Genomics of Anticonvulsant Efficacy in ChildrenTracy Glauser; Fiscal Year: 2004..different changes in gene expression in the blood of adult patients 24 hours later, and (3) valproic acid and carbamazepine monotherapy in children with epilepsy produces changes of gene expression in blood leukocytes that are ..
- CBT and Modafinil for Cocaine AddictionRobert Malcolm; Fiscal Year: 2009....
- RESEARCH TRAINING IN JUVENILE BIPOLAR DISORDERPablo Davanzo; Fiscal Year: 2002..In addition to furthering the candidate's transition to independent research, the proposed study would also contribute to our knowledge of pharmacological treatment and possible neurobiological markers of juvenile bipolar disorder. ..
- EFFECTIVENESS OF NALTREXONE IN A COMMUNITY SETTINGKathleen Brady; Fiscal Year: 2001....
- MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMANancy Temkin; Fiscal Year: 2004..abstract_text> ..
- AMLODIPINE TREATMENT FOR COCAINE DEPENDENCERobert Malcolm; Fiscal Year: 2001....
- Value of Technology to Transfer Discharge InformationJAMES GRAUMLICH; Fiscal Year: 2006..The cost outcome is the physician time required to use the discharge software. ..
- Planning Grant for CTSA at MUSCKathleen Brady; Fiscal Year: 2006..The development and subsequent implementation of the strategic plan has the potential to transform the research enterprise of MUSC and the state. [unreadable] [unreadable] [unreadable]..
- A Controlled Trial of NAC for Cocaine DependenceRobert Malcolm; Fiscal Year: 2009..placebo;and 3) to study cocaine craving/cue reactivity and withdrawal symptoms in subjects taking NAC or placebo. ..
- CLINICAL INVESTIGATION OF DRUG ABUSE DISORDERSKathleen Brady; Fiscal Year: 2008..The candidate would also use the time and funding provided through this award to continue to expand her activities in mentoring fellows and junior faculty. ..
- HORMONE REPLACEMENT IN MENOPAUSAL WOMEN WITH EPILEPSYCynthia Harden; Fiscal Year: 2002..The outcome of this study will be determined by comparing seizure frequency in the baseline phase with the treated phase between placebo and hormone treated groups. ..