carbamazepine

Summary

Summary: An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.

Top Publications

  1. ncbi Carbamazepine--the commonest cause of toxic epidermal necrolysis and Stevens-Johnson syndrome: a study of 7 years
    K Devi
    Department of Skin and VD, Medical College, Kottayam, India
    Indian J Dermatol Venereol Leprol 71:325-8. 2005
  2. ncbi Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians
    Timir Y Mehta
    Dr Rasiklal Shah Sarvajanik Hospital, Modasa 383315, India
    Indian J Dermatol Venereol Leprol 75:579-82. 2009
  3. pmc HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
    Mark McCormack
    Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
    N Engl J Med 364:1134-43. 2011
  4. ncbi Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan
    Pei Chen
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    N Engl J Med 364:1126-33. 2011
  5. ncbi Accounting for the solubility-permeability interplay in oral formulation development for poor water solubility drugs: the effect of PEG-400 on carbamazepine absorption
    Avital Beig
    Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Pharm Biopharm 81:386-91. 2012
  6. ncbi Removal of pharmaceuticals and fragrances in biological wastewater treatment
    Adriano Joss
    Eawag, Ueberlandstr 133, 8600 Dubendorf, Switzerland
    Water Res 39:3139-52. 2005
  7. pmc Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing
    S G Leckband
    Veterans Affairs San Diego Healthcare System, San Diego, California, USA
    Clin Pharmacol Ther 94:324-8. 2013
  8. pmc Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy
    Jinsook Kim
    Interdisciplinary Program in Neuroscience, Georgetown University, W215 Research Building, 3970 Reservoir Road, N W, Washington, DC 20057, USA
    J Pharmacol Exp Ther 323:165-73. 2007
  9. ncbi Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population
    Takeshi Ozeki
    Research Group for Pharmacogenomics, RIKEN Center for Genomic Medicine, Yokohama 230 0045, Japan
    Hum Mol Genet 20:1034-41. 2011
  10. ncbi ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients
    Takayuki Seo
    Kumamoto University, Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Pharmacogenomics 7:551-61. 2006

Detail Information

Publications325 found, 100 shown here

  1. ncbi Carbamazepine--the commonest cause of toxic epidermal necrolysis and Stevens-Johnson syndrome: a study of 7 years
    K Devi
    Department of Skin and VD, Medical College, Kottayam, India
    Indian J Dermatol Venereol Leprol 71:325-8. 2005
    ..The drugs commonly implicated as the cause of these drug reactions vary depending on host factors and the prescription pattern of drugs in that particular area...
  2. ncbi Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians
    Timir Y Mehta
    Dr Rasiklal Shah Sarvajanik Hospital, Modasa 383315, India
    Indian J Dermatol Venereol Leprol 75:579-82. 2009
    ..and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced ..
  3. pmc HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
    Mark McCormack
    Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
    N Engl J Med 364:1134-43. 2011
    b>Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions...
  4. ncbi Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan
    Pei Chen
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    N Engl J Med 364:1126-33. 2011
    b>Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), in Southeast Asian countries...
  5. ncbi Accounting for the solubility-permeability interplay in oral formulation development for poor water solubility drugs: the effect of PEG-400 on carbamazepine absorption
    Avital Beig
    Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Pharm Biopharm 81:386-91. 2012
    ..The apparent solubility of the lipophilic drug carbamazepine was measured in systems containing various levels of the co-solvent PEG-400...
  6. ncbi Removal of pharmaceuticals and fragrances in biological wastewater treatment
    Adriano Joss
    Eawag, Ueberlandstr 133, 8600 Dubendorf, Switzerland
    Water Res 39:3139-52. 2005
    ..removal of pharmaceuticals was mainly due to biological transformation and varied from insignificant (<10%, carbamazepine) to>90% (ibuprofen)...
  7. pmc Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing
    S G Leckband
    Veterans Affairs San Diego Healthcare System, San Diego, California, USA
    Clin Pharmacol Ther 94:324-8. 2013
    ..with an increased risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in response to carbamazepine treatment...
  8. pmc Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy
    Jinsook Kim
    Interdisciplinary Program in Neuroscience, Georgetown University, W215 Research Building, 3970 Reservoir Road, N W, Washington, DC 20057, USA
    J Pharmacol Exp Ther 323:165-73. 2007
    The aim of this study was to test the potential neurotoxicity of three antiepileptic drugs (AEDs), carbamazepine (5H-dibenzepine-5-carboxamide), topiramate [2,3:4,5-bis-O-(1-methylethylidene)-beta-d-fructopyranose sulfamate], and ..
  9. ncbi Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population
    Takeshi Ozeki
    Research Group for Pharmacogenomics, RIKEN Center for Genomic Medicine, Yokohama 230 0045, Japan
    Hum Mol Genet 20:1034-41. 2011
    An anticonvulsant, carbamazepine (CBZ), is known to show incidences of cutaneous adverse drug reactions (cADRs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS)...
  10. ncbi ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients
    Takayuki Seo
    Kumamoto University, Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Pharmacogenomics 7:551-61. 2006
    ..Our objective was to investigate the effect of ABCB1 polymorphisms on AED responsiveness and on the pharmacokinetics of carbamazepine (CBZ) in epileptic patients with the indication for CBZ therapy.
  11. ncbi Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome
    Chun Yu Wei
    Molecular Medicine Program, Taiwan International Graduate Program, Taipei, Taiwan
    J Allergy Clin Immunol 129:1562-9.e5. 2012
    ..Increasing studies have revealed that HLA alleles are the major genetic determinants of drug hypersensitivity; however, the underlying molecular mechanism remains unclear...
  12. ncbi A common mechanism of action for three mood-stabilizing drugs
    Robin S B Williams
    Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
    Nature 417:292-5. 2002
    Lithium, carbamazepine and valproic acid are effective mood-stabilizing treatments for bipolar affective disorder. The molecular mechanisms underlying the actions of these drugs and the illness itself are unknown...
  13. pmc Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin
    Sarah K Tate
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:5507-12. 2005
    Phenytoin and carbamazepine are effective and inexpensive anti-epileptic drugs (AEDs). As with many AEDs, a broad range of doses is used, with the final "maintenance" dose normally determined by trial and error...
  14. ncbi The effect of carbamazepine on human corticomuscular coherence
    C Nicholas Riddle
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK
    Neuroimage 22:333-40. 2004
    ..has recently been reported in a group of epileptic patients, all of whom were taking the anticonvulsant drug carbamazepine (CBZ)...
  15. ncbi HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
    Nahoko Kaniwa
    Division of Medicinal Safety Sciences, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Epilepsia 51:2461-5. 2010
    ..Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients...
  16. ncbi Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 11529, Taiwan
    Pharmacogenomics 11:349-56. 2010
    ..We previously reported that carbamazepine (CBZ)-SJS/TEN is strongly associated with the HLA-B*1502 in Han Chinese, which has been confirmed in other ..
  17. ncbi Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans
    Sae Hoon Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea
    Epilepsy Res 97:190-7. 2011
    Although the US FDA recommends screening for HLA-B*1502 allele in most of Asian ancestry before initiating carbamazepine therapy, the HLA associations with carbamazepine hypersensitivity in non-Chinese Asian populations remain unclear...
  18. ncbi Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese
    Celeste B L Man
    Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsia 48:1015-8. 2007
    A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-..
  19. ncbi 1-Methyl-1,2,3,4-tetrahydroisoquinoline enhances the anticonvulsant action of carbamazepine and valproate in the mouse maximal electroshock seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
    Neuropharmacology 50:133-42. 2006
    ..001). Similarly, 1-MeTHIQ (at 10 mg/kg) enhanced the antielectroshock activity of carbamazepine (CBZ) in mice, decreasing its ED50 from 10.8 to 7.8 mg/kg (P < 0.05)...
  20. ncbi Toxic effects and bioaccumulation of carbamazepine evaluated by biomarkers measured in organisms of different trophic levels
    Gabrielle Vernouillet
    Department of Biological Sciences TOXEN, Université de Québec à Montréal, Succ Centre Ville, Montreal, Quebec, Canada
    Chemosphere 80:1062-8. 2010
    ..platyurus and H. attenuata suggesting that redox activity of the lipophilic CBZ was at play. This study highlighted the processes of carbamazepine toxicity transfer between trophic levels in aquatic organisms.
  21. ncbi Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse
    Catharina Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska Hospital L8 00, 171 76 Stockholm, Sweden
    Neurobiol Dis 24:374-83. 2006
    b>Carbamazepine (CBZ) is a commonly used antiepileptic drug known to block voltage-gated sodium channels. Infants exposed to CBZ in utero show reduced head circumference, for reasons unknown...
  22. ncbi Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients
    Sandeep Grover
    Institute of Genomics and Integrative Biology IGIB, Council of Scientific and Industrial Research CSIR, Mall Road, Delhi 110 007, India
    Biochimie 92:1207-12. 2010
    ..C3435T in determining drug response to first line antiepileptic drugs (AEDs) namely phenobarbitone, phenytoin, carbamazepine and valproate in North Indian cohort of epilepsy patients...
  23. ncbi Effect of carbamazepine and oxcarbazepine on wild-type and mutant neuronal nicotinic acetylcholine receptors linked to nocturnal frontal lobe epilepsy
    Chiara Di Resta
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Eur J Pharmacol 643:13-20. 2010
    b>Carbamazepine (5H-dibenz[b,f]azepine-5-carboxamide) and oxcarbazepine (10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide) are widely used for the treatment of partial epilepsy...
  24. ncbi The mechanism of carbamazepine aggravation of absence seizures
    Lige Liu
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Royal Parade, Parkville 3050, Victoria, Australia
    J Pharmacol Exp Ther 319:790-8. 2006
    b>Carbamazepine (CBZ) aggravates many generalized seizures types, particularly absence seizures, but the mechanisms underlying this are poorly understood...
  25. ncbi A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy
    Won Joo Kim
    Departments of Pharmacology, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, 134 Sinchon dong, Seoul, Korea
    Pharmacogenet Genomics 20:249-56. 2010
    ..Therefore, genetic variations in the MRP2 gene may affect individual drug responses to the antiepileptic agent carbamazepine.
  26. ncbi Physiological condition status and muscle-based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine
    Zhi Hua Li
    Research Institute of Fish Culture and Hydrobiology, University of South Bohemia Ceske Budejovice, Zatisi 728 II, 398 25 Vodnany, Czech Republic
    J Appl Toxicol 30:197-203. 2010
    ..In this study, the chronic toxic effects of carbamazepine (CBZ), an anticonvulsant pharmaceutical commonly present in surface and ground water, on physiological ..
  27. ncbi Effects of carbamazepine and amitriptyline on tetrodotoxinresistant Na+ channels in immature rat trigeminal ganglion neurons
    Yun Kyung Hur
    Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 700 412, Korea
    Arch Pharm Res 31:178-82. 2008
    ..Here we report the effects of carbamazepine (CBZ) and amitriptyline (ATL) on tetrodotoxin-resistant (TTX-R) Na' channels expressed on immature rat TG ..
  28. ncbi Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of Carbamazepine in wastewater treatment and during groundwater infiltration
    M Clara
    Institute for Water Quality and Waste Management, Vienna University of Technology, A 1040 Vienna, Karlsplatz 13 226, Austria
    Water Res 38:947-54. 2004
    ..sources of pharmaceutical residues in surface waters, where high concentrations of the antiepileptic drug Carbamazepine have been detected. The solids retention time (SRT) is the most important parameter for the design of STPs...
  29. ncbi Antiepileptic drugs as human teratogens
    Mervyn J Eadie
    University of Queensland, and Royal Brisbane and Women s Hospital, Herston, Brisbane, Australia 4029, Australia
    Expert Opin Drug Saf 7:195-209. 2008
    ..There is still uncertainty concerning the risk of fetal malformation associated with the intake of various individual antiepileptic drugs in pregnant women...
  30. ncbi Normal intelligence in children with prenatal exposure to carbamazepine
    E Gaily
    Hospital for Children and Adolescents, 00029 HUS, Finland
    Neurology 62:28-32. 2004
    To investigate the effect of antiepileptic drugs, especially carbamazepine and valproate, on intelligence in prenatally exposed children of mothers with epilepsy.
  31. ncbi HLA-B*1502-bound peptides: implications for the pathogenesis of carbamazepine-induced Stevens-Johnson syndrome
    Chih Wen Ou Yang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    J Allergy Clin Immunol 120:870-7. 2007
    ..HLA-B(*)1502 tightly associated with carbamazepine (CBZ) induced these conditions in a Han Chinese population.
  32. ncbi Fate and mobility of pharmaceuticals in solid matrices
    Panagiota Drillia
    Department of Chemical Engineering, University of Patras, Karatheodori 1, 26500 Patras, Greece
    Chemosphere 60:1034-44. 2005
    ..The pharmaceuticals examined were carbamazepine, propranolol, diclofenac sodium, clofibric acid, sulfamethoxazole and ofloxacin...
  33. ncbi Clinical pharmacokinetics of oxcarbazepine
    Theodor W May
    Department of Biochemistry, Epilepsy Research Foundation, Bielefeld, Germany
    Clin Pharmacokinet 42:1023-42. 2003
    Oxcarbazepine is an antiepileptic drug with a chemical structure similar to carbamazepine, but with different metabolism...
  34. pmc Model-based approach to characterize efavirenz autoinduction and concurrent enzyme induction with carbamazepine
    Min Zhu
    Research and Development, Bristol Myers Squibb, P O Box 4000, Princeton, NJ 08543 4000, USA
    Antimicrob Agents Chemother 53:2346-53. 2009
    ..interaction model was developed to quantify efavirenz autoinduction and further induction with concurrent carbamazepine coadministration...
  35. ncbi Prospective assessment of levetiracetam pharmacokinetics during dose escalation in 4- to 12-year-old children with partial-onset seizures on concomitant carbamazepine or valproate
    Nathan B Fountain
    F E Dreifuss Comprehensive Epilepsy Program, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Epilepsy Res 74:60-9. 2007
    ..metabolite ucb L057 in children with partial-onset seizures and determine whether it is affected by adjunctive carbamazepine or valproate...
  36. ncbi Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea
    YoungHee Kim
    School of Public Health, Seoul National University, Seoul, Republic of Korea
    Environ Int 33:370-5. 2007
    ..In this study, the four most abundantly used pharmaceuticals in Korea, namely acetaminophen, carbamazepine, cimetidine, and diltiazem, and six sulfonamide related antibiotics, including sulfamethoxazole, ..
  37. ncbi Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid
    Hamza Karabiber
    Kahramanmaras Sutcuimam Universitesi, Tip Fakultesi, Pediatri Anabilim Dalý 46050, Kahramanmaras, Turkey
    Brain Dev 25:113-5. 2003
    ..The aim of this study is to investigate the effect of valproate (VA) and carbamazepine (CBZ) on the serum levels of HMC, B12, and FA...
  38. ncbi Increased bone turnover in prepubertal, pubertal, and postpubertal patients receiving carbamazepine
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Italy
    Epilepsia 43:1488-92. 2002
    To study the markers of bone turnover in epilepsy patients in the different stages of the pubertal growth before and after the beginning of carbamazepine (CBZ) monotherapy.
  39. ncbi Characterization of interaction and the effect of carbamazepine on the structure of human serum albumin
    Shankara S Kalanur
    Department of Chemistry, Karnatak University, Dharwad 580 003, India
    J Pharm Biomed Anal 53:660-6. 2010
    The binding of carbamazepine (CBZ) to human serum albumin (HSA) was investigated under simulative physiological conditions. In this study, intrinsic fluorescence of tryptophan-214 in HSA was monitored upon the addition of CBZ...
  40. ncbi Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats
    K H Reeta
    Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India
    Eur J Pharmacol 644:106-12. 2010
    The antiepileptic drugs, phenobarbitone and carbamazepine are well known to cause cognitive impairment on chronic use...
  41. ncbi Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China
    X T Wu
    Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    Epilepsy Behav 19:405-8. 2010
    The aim of this study was to investigate the association between carbamazepine (CBZ)-induced cutaneous adverse drug reactions (cADRs) and the HLA-B*1502 allele among patients from central China...
  42. ncbi Lamotrigine for trigeminal neuralgia: efficacy and safety in comparison with carbamazepine
    Sameer Shaikh
    Department of Oral Medicine and Oral Pathology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
    J Chin Med Assoc 74:243-9. 2011
    ..In this study, we evaluated the efficacy and occurrence of side effects of lamotrigine (LTG) in comparison with carbamazepine (CBZ), in trigeminal neuralgia (TN) patients.
  43. ncbi Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024
    António F Ambrósio
    Department of Cell Biology, Center for Neuroscience of Coimbra, Portugal
    Neurochem Res 27:121-30. 2002
    b>Carbamazepine (CBZ) has been extensively used in the treatment of epilepsy, as well as in the treatment of neuropathic pain and affective disorders...
  44. ncbi Rocuronium-induced neuromuscular block is affected by chronic carbamazepine therapy
    A Spacek
    Department of Anesthesia and General Intensive Care B, University of Vienna, Austria
    Anesthesiology 90:109-12. 1999
    ..This study investigated the influence of chronic carbamazepine therapy on the neuromuscular block induced by the new muscle relaxant rocuronium.
  45. ncbi Drug interaction and pharmacokinetic modeling of oxcarbazepine in korean patients with epilepsy
    Kyoung Jin Park
    Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Clin Neuropharmacol 35:40-4. 2012
    ....
  46. ncbi HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review
    V L Yip
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    Clin Pharmacol Ther 92:757-65. 2012
    b>Carbamazepine (CBZ) therapy is associated with cutaneous adverse reactions in up to 10% of patients. Predisposition to these hypersensitivity reactions has been linked to the human leukocyte antigen (HLA) genotype...
  47. ncbi Zebrafish (Danio rerio) embryos as a model for testing proteratogens
    Stefan Weigt
    Institute of Toxicology, Merck KGaA, 64293 Darmstadt, Germany
    Toxicology 281:25-36. 2011
    ..and describes results obtained for 10 proteratogens: 2-acetylaminofluorene, benzo[a]pyrene, aflatoxin B(1), carbamazepine, phenytoin, trimethadione, cyclophosphamide, ifosfamide, tegafur and thio-TEPA...
  48. ncbi Eosinophilic leukemoid reaction associated with carbamazepine hypersensitivity
    Gaurish Laad
    Department of Skin and VD, Goa Medical College and Hospitals, Bambolim, Goa, India
    Indian J Dermatol Venereol Leprol 71:35-7. 2005
    b>Carbamazepine is widely used in the treatment of epilepsy, neuralgic pain, and bipolar affective disorders...
  49. ncbi Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han population
    Fa Yun Hu
    Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
    Seizure 20:160-2. 2011
    ..In the present study, we conducted a pilot study to detect a possible association of oxcarbazepine (OXC)-induced MPE with HLA-B*1502 allele in Chinese Han population...
  50. ncbi Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy
    Hongmei Meng
    The First Hospital of Jilin University, Changchun, People s Republic of China
    Epilepsy Behav 21:27-30. 2011
    ..We sought to investigate the effects of ABCB1 polymorphisms on plasma carbamazepine (CBZ) concentrations and pharmacoresistance in Chinese patients with epilepsy...
  51. ncbi Preparation of carbamazepine-Soluplus solid dispersions by hot-melt extrusion, and prediction of drug-polymer miscibility by thermodynamic model fitting
    Jelena Djuriš
    Department of Pharmaceutical Technology and Cosmetology, University of Belgrade, Belgrade, Serbia
    Eur J Pharm Biopharm 84:228-37. 2013
    ..The present study investigates the feasibility of forming solid dispersions of carbamazepine (CBZ) into polyethyleneglycol-polyvinyl caprolactam-polyvinyl acetate grafted copolymer (Soluplus) by hot-melt ..
  52. ncbi Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-β pathology in a mouse model of Alzheimer's disease
    Lixi Li
    Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Curr Alzheimer Res 10:433-41. 2013
    ..The aim of this study is to test if carbamazepine (CBZ), an anti-epileptic drug that has a potent autophagy enhancement effect, has anti-AD effects in APP(swe)/..
  53. ncbi Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock-induced seizures in rats
    Monika Pahuja
    Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India
    Epilepsy Behav 25:368-73. 2012
    ..the pharmacokinetic and pharmacodynamic interactions of HEZJ with phenytoin (PHT), phenobarbitone (PB), and carbamazepine (CBZ) in maximal electroshock (MES)-induced seizures in male Wistar rats...
  54. ncbi Fish embryo toxicity of carbamazepine, diclofenac and metoprolol
    Evert Jan van den Brandhof
    Laboratory for Ecological Risk Assessment, RIVM, PO Box 1, Bilthoven 3720 BA, The Netherlands
    Ecotoxicol Environ Saf 73:1862-6. 2010
    ..In this FET test 2-h-old zebrafish embryos were exposed for 72 h to carbamazepine, diclofenac and metoprolol to observe effects on embryo mortality, gastrulation, somite formation, tail ..
  55. ncbi The comparative evaluation of gabapentin and carbamazepine for pain management in Guillain-Barré syndrome patients in the intensive care unit
    Chandra Kant Pandey
    Department of Anaesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Anesth Analg 101:220-5, table of contents. 2005
    We evaluated the effects of gabapentin and carbamazepine for pain relief in 36 Guillain-Barré syndrome patients...
  56. pmc In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
    Bao Chen
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Nanomedicine 7:199-209. 2012
    ..With the aim of improving adsorption capacity and accordingly achieving high drug loading, ordered mesoporous silica with a high surface area and narrow pore size distribution was synthesized and used in a liquisolid formulation...
  57. ncbi Fecal coliforms, caffeine and carbamazepine in stormwater collection systems in a large urban area
    Sebastien Sauve
    Departement de Chimie, Universite de Montreal, Montreal, QC, Canada
    Chemosphere 86:118-23. 2012
    ..storm sewer outfall pipes that collect storm waters across the Island of Montréal were analyzed for caffeine, carbamazepine and fecal coliforms...
  58. ncbi Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine)
    Yousef Javadzadeh
    Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran
    Int J Pharm 341:26-34. 2007
    Different liquisolid formulations of carbamazepine were accomplished by dissolving the drug in the non-toxic hydrophilic liquids, and adsorbing the solution onto the surface of silica...
  59. ncbi Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio)
    R Triebskorn
    Steinbeis Transfer Center for Ecotoxicology and Ecophysiology, Blumenstr 13, 72108 Rottenburg, Germany
    Anal Bioanal Chem 387:1405-16. 2007
    ..potential effects of human pharmaceuticals in aquatic wildlife, laboratory experiments were conducted with carbamazepine, clofibric acid, metoprolol, and diclofenac using fish as test organisms...
  60. ncbi Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodies
    Yongjun Zhang
    Department of Environmental Process Engineering, Institute of Environmental Technology, Technical University of Berlin, Strasse des 17 Juni 135, Berlin 10623, Germany
    Chemosphere 73:1151-61. 2008
    In the aquatic environment, pharmaceuticals have been widely found. Among them, carbamazepine and diclofenac were detected at the highest frequency...
  61. ncbi Effects of pharmaceuticals on aquatic invertebrates. Part I. The antiepileptic drug carbamazepine
    M Oetken
    Department of Ecology and Evolution Ecotoxicology, Johann Wolfgang Goethe University Frankfurt am Main, Siesmayerstrasse 70, Frankfurt, D 60054, Germany frankfurt de
    Arch Environ Contam Toxicol 49:353-61. 2005
    The effects of the antiepileptic drug carbamazepine (CBZ) were studied in three freshwater invertebrate species representing different taxonomic groups, life histories, and habitats in aquatic ecosystems...
  62. pmc Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study
    Janneke Jentink
    Department of Pharmacoepidemiology and Pharmacoeconomics, Division of Pharmacy, University of Groningen, Netherlands
    BMJ 341:c6581. 2010
    To identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy.
  63. ncbi Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour
    J J Idänpään-Heikkilä
    The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Pain 79:281-90. 1999
    ..b>Carbamazepine was effective only after doses (> or =10 mg/kg s.c...
  64. ncbi Kinetic changes and modulation by carbamazepine on voltage-gated sodium channels in rat CA1 neurons after epilepsy
    Guang Chun Sun
    Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098SM, The Netherlands
    Acta Pharmacol Sin 27:1537-46. 2006
    To study whether the functional properties of sodium channels, and subsequently the channel modulation by carbamazepine (CBZ) in hippocampal CA1 neurons can be changed after epileptic seizures.
  65. ncbi P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain
    H Potschka
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, , D-30559 Hannover, Germany
    Neuroreport 12:3557-60. 2001
    ..In the present study, we used in vivo microdialysis in rats to study whether the concentration of carbamazepine in the extracellular fluid of the cerebral cortex can be enhanced by inhibition of PGP or MRP, using the PGP ..
  66. ncbi Differential efficacy of lithium and carbamazepine in the prophylaxis of bipolar disorder: results of the MAP study
    N Kleindienst
    Psychiatric Hospital of the University of Munich, Germany
    Neuropsychobiology 42:2-10. 2000
    ..5 years, the differential efficacy of lithium versus carbamazepine was compared in 171 bipolar patients (DSM-IV)...
  67. ncbi The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children
    Ali Aycicek
    Sanliurfa Children s Hospital, Sanliurfa, Turkey
    Eur Neurol 57:65-9. 2007
    ..We studied the effect of antiepileptic monotherapy on serum level of total antioxidant capacity, lipid hydroperoxide, total peroxide, oxidative stress index, and individual serum antioxidants such as albumin, bilirubin and uric acid...
  68. ncbi Effects of carbamazepine on morphine-induced behavioral sensitization in mice
    Jun Xu Li
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100083, PR China
    Brain Res 1019:77-83. 2004
    Effects of carbamazepine on behavioral sensitization to morphine in mice has been investigated. Mice treated daily for 7 days with morphine (10 mg/kg) induced behavioral sensitization. Carbamazepine (10, 20, 40 mg/kg, i.p...
  69. ncbi Spatiotemporal distribution of pharmaceuticals in the Douro River estuary (Portugal)
    Tânia Vieira Madureira
    Health Sciences Research Center of the Superior Institute Health Sciences North, Gandra, Paredes, Portugal
    Sci Total Environ 408:5513-20. 2010
    ..The maximum concentrations found were 178ng/L for carbamazepine, 3.65ng/L for diazepam, 70.3ng/L for fenofibric acid, 3.18ng/L for propranolol, 15...
  70. ncbi Increased antibody levels to desmogleins 1 and 3 after administration of carbamazepine
    T Yoshimura
    Pharmaceutical Division, Ogaki Municipal Hospital, Ogaki, Japan
    Clin Exp Dermatol 26:441-5. 2001
    ..have been reported to occur in individuals after exposure to a variety of drugs, but pemphigus caused by carbamazepine is not common...
  71. ncbi Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine
    A Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Via dei Vestini 5, I 66100, Chieti, Italy
    Epilepsy Res 41:253-7. 2000
    To evaluate plasma homocysteine (Hcy) concentrations in children receiving sodium valproate (VPA) and carbamazepine (CBZ), monotherapy, in comparison with healthy control subjects and to determine the possible relationship between Hcy ..
  72. ncbi A 6-month, multicenter, open-label evaluation of beaded, extended-release carbamazepine capsule monotherapy in bipolar disorder patients with manic or mixed episodes
    Terence A Ketter
    Stanford University School of Medicine, Stanford, California 94305 5723, USA
    J Clin Psychiatry 65:668-73. 2004
    b>Carbamazepine is frequently used for treating bipolar disorder, but few large trials have assessed its efficacy in preventing relapse...
  73. ncbi Comparison of the four anhydrous polymorphs of carbamazepine and the crystal structure of form I
    Adam L Grzesiak
    Department of Chemistry and the Macromolecular Science and Engineering Program, The University of Michigan, Ann Arbor, Michigan 48109 1055, USA
    J Pharm Sci 92:2260-71. 2003
    For decades, carbamazepine (CBZ) has served as a model compound for groups engaged in the study of crystal polymorphism...
  74. ncbi Model-based evaluation of reduction strategies for micropollutants from wastewater treatment plants in complex river networks
    Christoph Ort
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, CH 8600 Dubendorf, Switzerland
    Environ Sci Technol 43:3214-20. 2009
    ..At base flow conditions, carbamazepine concentrations (parent compound only) are ubiquitously below a water quality criterion of 0.5 microg L(-1)...
  75. pmc Association between SCN1A polymorphism and carbamazepine-resistant epilepsy
    Tomohide Abe
    Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan
    Br J Clin Pharmacol 66:304-7. 2008
    To establish whether the SCN1A IVS5-91 G > A polymorphism of the SCN1A gene, which encodes the neuronal sodium channel alpha subunit, affects responsiveness to the antiepileptic drugs (AEDS) carbamazepine and/or phenytoin.
  76. ncbi Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig
    Alyson Fox
    Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK
    Pain 105:355-62. 2003
    ..Oxcarbazepine and carbamazepine (3-100 mg x kg(-1)) did not affect mechanical hyperalgesia or tactile allodynia induced by partial sciatic ..
  77. ncbi Carbamazepine for prevention of oxaliplatin-related neurotoxicity in patients with advanced colorectal cancer: final results of a randomised, controlled, multicenter phase II study
    Stefan von Delius
    Department of Internal Medicine II, Technical University of Munich, Munich, Germany
    Invest New Drugs 25:173-80. 2007
    Oxaliplatin-induced neurotoxicity is a growing, relevant clinical problem. In this study we evaluated the efficacy and safety of carbamazepine for prevention of oxaliplatin-associated neuropathy in patients with advanced colorectal cancer.
  78. pmc Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide
    Jonathan W Theile
    Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Pharmacol 80:724-34. 2011
    ..Furthermore, pain associated with PEPD, but not IEM, is alleviated by the sodium channel inhibitor carbamazepine. We speculated that selective attenuation of PEPD-enhanced resurgent currents might contribute to this ..
  79. ncbi HLA class I markers in Japanese patients with carbamazepine-induced cutaneous adverse reactions
    Hiroko Ikeda
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 51:297-300. 2010
    b>Carbamazepine (CBZ) is frequently used for treating epilepsy, but this drug causes cutaneous adverse drug reactions (cADRs) that may range from mild to severe...
  80. ncbi Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition
    C Simon
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Acta Neurol Scand 115:232-42. 2007
    ..absorption and bioavailability might contribute to inadequate control of seizures under treatment with carbamazepine and phenytoin...
  81. pmc Carbamazepine is not a substrate for P-glycoprotein
    A Owen
    Department of Pharmacology and Therapeutics, The University of Liverpool, L69 3GE, UK
    Br J Clin Pharmacol 51:345-9. 2001
    AIMS: To determine whether the anticonvulsant carbamazepine (CBZ), a known CYP3A4 substrate, is also a substrate for the multidrug efflux transporter P-glycoprotein (Pgp)...
  82. ncbi Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey
    Gulay Oner Ozgon
    Department of Genetics, Institute for Experimental Medical Research, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
    Eur Neurol 59:67-70. 2008
    We investigated the prevalence of this multidrug resistance 1 gene (MDR1) polymorphism in drug-responsive versus drug-resistant epilepsy patients treated with carbamazepine (CBZ), which is a substrate of this protein.
  83. pmc The autophagy-inducing drug carbamazepine is a radiation protector and mitigator
    Hyun Kim
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Int J Radiat Biol 87:1052-60. 2011
    To determine whether Carbamazepine (CBZ) is a radiation protector and/or mitigator.
  84. ncbi Bipolar disorder
    Bruno Muller-Oerlinghausen
    Department of Psychiatry, Research Group of Clinical Psychopharmacology, Freie Universitat Berlin, Berlin
    Lancet 359:241-7. 2002
    ..They also possess well documented antisuicidal effects. Second choice prophylactic treatments are carbamazepine and valproate, although evidence of their effectiveness is weaker.
  85. pmc A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia
    Tanya Z Fischer
    Department of Neurology, Yale University School of Medicine, New Haven, CT 16510, USA
    Ann Neurol 65:733-41. 2009
    ..Inherited erythromelalgia (IEM) has been linked to gain-of-function mutations of Na(v)1.7. We now report a novel mutation (V400M) in a three-generation Canadian family in which pain is relieved by carbamazepine (CBZ).
  86. ncbi Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei, Taiwan
    Pharmacogenet Genomics 16:297-306. 2006
    The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (..
  87. ncbi Extended release carbamazepine in the treatment of pathological gambling: an open-label study
    Donald W Black
    University of Iowa Roy J and Lucille A Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1191-4. 2008
    The efficacy and tolerability of extended release carbamazepine was tested in the treatment of pathological gambling (PG).
  88. ncbi Carbamazepine and topiramate modulation of transient and persistent sodium currents studied in HEK293 cells expressing the Na(v)1.3 alpha-subunit
    Guang Chun Sun
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 48:774-82. 2007
    ..The interactions of the AEDs carbamazepine (CBZ) and topiramate (TPM) with the persistent and transient Na(+) current were investigated.
  89. ncbi Dissolution rate improvement of poorly water-soluble drugs obtained by adsorbing solutions of drugs in hydrophilic solvents onto high surface area carriers
    Heike Friedrich
    College of Pharmacy, Freie Universitat Berlin, Berlin, Germany
    Eur J Pharm Biopharm 62:171-7. 2006
    The dissolution rate of the model drugs carbamazepine and nifedipine was improved by adsorbing solutions of the drugs in hydrophilic non-volatile or volatile solvents onto carriers with a large surface area...
  90. ncbi Stimulation of retinoic acid-induced functional sodium iodide symporter (NIS) expression and cytotoxicity of ¹³¹I by carbamazepine in breast cancer cells
    Michael J Willhauck
    Department of Internal Medicine II, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistrasse 15, 81377, Muenchen, Germany
    Breast Cancer Res Treat 125:377-86. 2011
    ..pregnane-X-receptor (PXR) forming a heterodimer with the retinoid-X-receptor (RXR), we examined the effect of carbamazepine (CBZ), a potent activator of PXR, on atRA-induced NIS expression and therapeutic efficacy of (131)I in MCF-7 ..
  91. ncbi The analysis of a group of acidic pharmaceuticals, carbamazepine, and potential endocrine disrupting compounds in wastewater irrigated soils by gas chromatography-mass spectrometry
    Juan C Durán-Álvarez
    Instituto de Ingenieria, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, D F, Mexico
    Talanta 78:1159-66. 2009
    ..This article reports a method for a range of acidic pharmaceuticals, carbamazepine, and endocrine disrupting compounds in soils with final analysis by gas chromatography-mass spectrometry...
  92. ncbi Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population
    Chaichon Locharernkul
    Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Epilepsia 49:2087-91. 2008
    Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations...
  93. ncbi Activation of T cells by carbamazepine and carbamazepine metabolites
    Ying Wu
    Department of Pharmacology, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK
    J Allergy Clin Immunol 118:233-41. 2006
    ..T-cell-mediated hypersensitivity is a rare but serious manifestation of drug therapy...
  94. ncbi Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial
    Madhur Gupta
    Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
    Epilepsia 45:1636-9. 2004
    ..The study was designed to assess its effects on the blood levels of antioxidant enzymes in children with epilepsy receiving carbamazepine (CBZ).
  95. ncbi Treatment with carbamazepine and gabapentin of a patient with primary erythermalgia (erythromelalgia) identified to have a mutation in the SCN9A gene, encoding a voltage-gated sodium channel
    J Natkunarajah
    Department of Dermatology, St George s Hospital, London, UK
    Clin Exp Dermatol 34:e640-2. 2009
    ..We report a family identified to have a mutation in the SCN9A gene, in which one severely affected family member has responded to the therapeutic combination of gabapentin and carbamazepine treatment.
  96. ncbi Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods
    S Sethia
    College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Int J Pharm 272:1-10. 2004
    This study compares the physicochemical properties of carbamazepine (CBZ) solid dispersions prepared by either a conventional solvent evaporation versus a supercritical fluid process...
  97. ncbi HLA-B locus in Caucasian patients with carbamazepine hypersensitivity
    Ana Alfirevic
    Department of Pharmacology and Therapeutics, The University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK
    Pharmacogenomics 7:813-8. 2006
    A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS).
  98. ncbi Hypersensitivity syndrome induced by anticonvulsants: possible cross-reactivity between carbamazepine and lamotrigine
    Karim Aouam
    Laboratoire de Pharmacologie, Faculte de medecine de Monastir, Rue Avicenne, 5019 Monastir, Tunisia
    J Clin Pharmacol 49:1488-91. 2009
    A 14-year-old male presents with erythroderma and fever 44 days after carbamazepine intake. Laboratory exams show eosinophilia and elevated liver enzymes, and thoracic imaging reveals interstitial pneumonitis...
  99. ncbi Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients
    P W Park
    Department of Laboratory Medicine, Gil Hospital, Gachon University, Incheon, Korea
    J Clin Pharm Ther 34:569-74. 2009
    b>Carbamazepine (CBZ) is metabolized mainly by the CYP3A family of enzymes, which includes CYP3A4 and CYP3A5. Several studies have suggested that the CYP3A5*3 genotype influences the pharmacokinetics of CYP3A substrates...
  100. ncbi Drug-induced systemic lupus erythematosus after 7 years of treatment with carbamazepine
    Lorenzo Pelizza
    Psychiatric Operative Unit n 25 of Casalmaggiore Cremona, Oglio Po General Hospital, Italy
    Acta Biomed 77:17-9. 2006
    Aim of this work is to describe a late-onset of carbamazepine-induced systemic lupus erythematosus (SLE) in a 38-year-old female patient who had been treated with daily carbamazepine (CBZ) for 7 years because of a bipolar I disorder...
  101. ncbi Effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemical epileptogenesis in rats
    Tarun Arora
    Department of Pharmacology, University College of Medical Sciences, University of Delhi, Delhi, India
    Basic Clin Pharmacol Toxicol 106:372-7. 2010
    The present study assessed the effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemically induced epileptogenesis in rats...

Research Grants62

  1. Cellular Efflux and Metabolism of Protease Inhibitors
    Ashim Mitra; Fiscal Year: 2004
    ..will be first validated using model compound in each class: Tolbutamide - Class-A, Rhodamine 123 - Class-B, Carbamazepine - Class-C, and Cortisol - Class-D...
  2. Antiepileptogenic & Disease Modifying Effects of AEDs
    Asla Pitkanen; Fiscal Year: 2005
    ..Aim of the present study is to investigate whether administration of 3 standard antiepileptic drugs (carbamazepine, valproate, levetiracetam) as monotherapy during epileptogenic phase (1) prevents the development of epilepsy, ..
  3. Trigeminal Neuropathic Pain Mechanisms
    Michael Henry; Fiscal Year: 2006
    ..channels following peripheral and central injury, since patients with trigeminal neuralgia usually respond to carbamazepine, while patients with peripheral trigeminal neuropathy rarely obtain significant relief with only carbamazepine...
  4. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
    ..BPD, but, because of its side effects, anti-convulsants (including valproic acid, lamotrigine, topiramate &carbamazepine) &atypical anti-psychotics have also been prescribed...
  5. Role of the Unfolded Protein Response in Beta Cell
    Randal J Kaufman; Fiscal Year: 2013
    ..p cells that produce excessive proinsulin? We will test chemical chaperones, GLP-1, cyclosporin A, rapamycin/carbamazepine, etc...
  6. Carbamazepine for severe liver disease due to antitrypsin deficiency
    David H Perlmutter; Fiscal Year: 2012
    ..shown to enhance autophagic degradation of aggregation-prone proteins with polyglutamine repeats, we selected carbamazepine (CBZ) for detailed studies of its effect on ATZ because it has the most extensive safety profile in humans...
  7. Optimization of the FPI model for epilepsy therapy development
    RAIMONDO D'AMBROSIO; Fiscal Year: 2013
    ..and generates CRSSs that are fully blocked by halothane, partially blocked by valproate, and very resistant to carbamazepine and carisbamate...
  8. Design and synthesis of novel anticonvulsant molecules.
    Rajesh Kumar Mishra; Fiscal Year: 2011
    ..MB003), both exhibit lower ED50s than many other anti-convulsant drugs including valproic acid, felbamate, carbamazepine, phenytoin, and ethosuximide...
  9. The Effects of Antiepileptic Drugs on Serologic Indices of Vascular Risk
    Scott Mintzer; Fiscal Year: 2012
    ..Aim II: We will test the hypothesis that patients taking PHT or carbamazepine (CBZ) who are switched to a non-inducing AED will experience significant reductions in serum CRP and ..
  10. Drug brain biotransformation in human refractory epilepsy
    Nicola Marchi; Fiscal Year: 2013
    ..the BBB (and neurons) in human DRE brain;d) Overexpression of CYP3A4 in DRE EC is associated with exaggerated carbamazepine (CBZ) metabolism. This new metabolic pathway produces the toxic CBZ metabolite quinolic acid (QA)...
  11. Sodium Channel Gene Variation in the Treatment of Epilepsy
    Katherine D Holland; Fiscal Year: 2013
    ..of this proposal is to determine the influence of genetic alterations in sodium channel genes on response to carbamazepine (CBZ), one of the main first line treatments for epilepsy...
  12. CHROMATOGRAPHIC AUTOMATION OF IMMUNOASSAYS
    David S Hage; Fiscal Year: 2013
    ..immunoassays, as recently demonstrated for compounds such as warfarin, thyroxine, phenytoin and carbamazepine. Future studies will build on these previous efforts by considering new analytes and approaches that can be ..
  13. Therapeutic Use of Autophagy Enhancer Drugs for Alzheimer's Disease
    David H Perlmutter; Fiscal Year: 2012
    ..In our recent work we have discovered that carbamazepine (CBZ), a drug that has been used for years as an anticonvulsant with a wide margin of safety, enhanced the ..
  14. Pilot PET Study Characterizing [1-11C] Arachadonic Acid in Bipolar Disorder
    M Elizabeth Sublette; Fiscal Year: 2013
    ..In animal studies, mood stabilizers lithium, valproate, carbamazepine, and lamotrigine downregulate the brain AA cascade5...
  15. New therapies for liver fibrosis and hyperproliferation in alpha1-AT deficiency
    David H Perlmutter; Fiscal Year: 2013
    ..Perlmutter, Michalopoulos and Stolz showed that, by enhancing autophagic degradation of mutant ATZ, carbamazepine could reduce hepatic ATZ load and fibrosis in the PiZ mouse model of ATD, and therein provided evidence that ..
  16. EFFECTS OF ANTICONVULSANTS ON GLIAL ION TRANSPORT
    Steve White; Fiscal Year: 1991
    ..be acutely and chronically exposed to therapeutic concentrations of the prototype anticonvulsants phenytoin, carbamazepine, valproate, diazepam, ethosuximide, acetazolamide, and to the calcium channel blocker flunarizine...
  17. Imaging the effect of centrotemporal spikes and seizures on language in children
    Jennifer Vannest; Fiscal Year: 2013
    ..The future double blind RCT will compare levetiracetam to carbamazepine (the current standard of care that does not eliminate CTS) in BECTS...
  18. LITHIUM IN AGGRESSIVE CHILDREN WITH CONDUCT DISORDER
    Magda Campbell; Fiscal Year: 1993
    ..g.,POMS). Therefore alternate drugs have to be studied. The rationale for studying carbamazepine is twofold...
  19. Pharmacoresistance in rats with kainate-induced epilepsy
    F Dudek; Fiscal Year: 2005
    ..to high doses of topiramate lasting several days? Are they resistant to similar treatments of carbamazepine, which is probably the most widely used AED? Are these rats pharmacoresistant to topiramate when it is used as ..
  20. PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPY
    THOMAS FERRARO; Fiscal Year: 2003
    ..ACD testing will involve dose-reponse studies with a panel of clinically relevant ACDs: phenytoin, carbamazepine, vaiproic acid and gamma-vinyl GABA...
  21. CARBAMAZEPINE IN THE TREATMENT OF COCAINE ABUSE
    JAMES HALIKAS; Fiscal Year: 1993
    ..studies conducted by the University of Minnesota Chemical Dependency Treatment Program provide evidence that carbamazepine may be beneficial in the treatment of cocaine abuse...
  22. NEUROPHARMACOLOGY OF THE TRIGEMINAL NUCLEUS
    GERHARD FROMM; Fiscal Year: 1992
    b>Carbamazepine has become the drug of choice in the treatment of trigeminal neuralgia. However, it can have significant side effects as well as not being effective in some cases...
  23. VALPROATE VERSUS LITHIUM IN BIPOLAR RAPID CYCLING
    Joseph Calabrese; Fiscal Year: 1999
    ..Although controlled trials have demonstrated the efficacy of carbamazepine in the treatment of rapid-cycling bipolar disorder, the response to carbamazepine frequently deteriorates over ..
  24. INTELLIGENT REFRIGERATED AUTOMATIC STORAGE SYSTEM
    DAN CORNELL; Fiscal Year: 1993
    ..This is a proposal for a random assignment, double-blind, placebo- controlled clinical trial of carbamazepine in 66 probable and possible AD outpatients with clinically significant behavioral disorders...
  25. CHEMICAL BASIS FOR DRUG TOXICITY
    MARJORIE HORNING; Fiscal Year: 1980
    Studies of epoxide formation from drugs (phenytoin and carbamazepine) and related compounds (naphthalene) with aromatic structures indicate that toxicity may be related to epoxide formation, and that diepoxides may be more toxic than ..
  26. ALTERING BEHAVIORAL RISK FOR DRUG DEPENDENCE
    DON CHEREK; Fiscal Year: 2001
    ..disorder (ASPD), probably the highest risk population and (2) matched controls the drug to be employed are: carbamazepine, fenfluramine, methylphenidate and paroxetine...
  27. Early Randomized Surgical Epilepsy Trial
    Jerome Engel; Fiscal Year: 2007
    ..abstract_text> ..
  28. EPILEPSY CLINICAL RESEARCH PROGRAM
    Ilo Leppik; Fiscal Year: 2006
    ..The PK characteristics of carbamazepine (CBZ), valproic acid (VPA), lamotrigine (LTG), and topiramate (TPM) in elderly patients will be determined ..
  29. OXCARBAZEPINE--PREGNANCY AND INFANT OUTCOME
    JOAN LOCKARD; Fiscal Year: 1999
    ..b>Carbamazepine (CBZ: Tegretol) is the drug choice in temperol lobe epilepsy and has been used as an alternative to phenytoin-..
  30. PARENTERAL FORMULATION FOR CARBAMAZEPINE
    KERRY ESTES; Fiscal Year: 1991
    ..Adapted from Applicant's Abstract) The favorable efficacy, toxicity and adverse side-effect profiles of carbamazepine (CBZ) contribute to its widespread and increasing use to control seizure in the epileptic patient...
  31. POLYTHERAPY MECHANISMS IN PREGNANCY
    JOAN LOCKARD; Fiscal Year: 1993
    ..b>Carbamazepine (CBZ) apparently forms at least one reactive arene oxide metabolite, but no studies have been conducted to ..
  32. STUDIES RELEVANT TO RATIONAL ANTIEPILEPTIC THERAPY
    KENNETH DUDLEY; Fiscal Year: 1980
    Further refinements will be carried out on new gas chromatographic assays of valproic acid (VPA) and carbamazepine (CBZ) developed during year 01...
  33. CARBAMAZEPINE FORMULATION FOR IV EPILEPSY THERAPY
    MICHAEL VIOLANTE; Fiscal Year: 1993
    ..No IV formulation exists for carbamazepine (CBZ), a drug of choice for epilepsy therapy...
  34. DEVELOPMENT OF PARENTERAL FORMULATION FOR CARBAMAZEPINE
    Marcus Brewster; Fiscal Year: 1993
    The favorable therapeutic profile of carbamazepine (CBZ) explains its widespread use in epileptic patients. However, no parenteral formulation is available for CBZ...
  35. Pharmacoresistance to AEDs during epileptogenesis
    HEIDI GRABENSTATTER; Fiscal Year: 2007
    ..The dose effects of the traditional AED, carbamazepine, on spontaneous convulsive seizure activity will be tested late vs...
  36. GERIATRIC MENTAL HEALTH ACADEMIC AWARD
    Pierre Tariot; Fiscal Year: 1992
    ..The second is symptomatic pharmacotherapy, pursued by the study of the symptomatic benefit of carbamazepine and deprenyl in patients with dementia...
  37. Bipolar Statistical Summit:Methodologies to Advance Long Term Intervention Trials
    Charles Bowden; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. Neurodevelopmental Effects of Antiepileptic Drugs II
    Kimford Meador; Fiscal Year: 2009
    ..in terms of their children's neurobehavioral development after in utero exposure to AED monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate)...
  39. PROGESTERONE THERAPY FOR WOMEN WITH EPILEPSY
    Andrew Herzog; Fiscal Year: 2008
    ..30 x .35) 100,000 women with catamenial epilepsy and perhaps many more women with no a priori demonstrated hormonal sensitivity to seizure occurrence. ..
  40. CLINICAL PHARMACOLOGY OF CHILDHOOD EPILEPSY
    Tracy Glauser; Fiscal Year: 2003
    ....
  41. Blood Genomics of Anticonvulsant Efficacy in Children
    Tracy Glauser; Fiscal Year: 2004
    ..different changes in gene expression in the blood of adult patients 24 hours later, and (3) valproic acid and carbamazepine monotherapy in children with epilepsy produces changes of gene expression in blood leukocytes that are ..
  42. CBT and Modafinil for Cocaine Addiction
    Robert Malcolm; Fiscal Year: 2009
    ....
  43. RESEARCH TRAINING IN JUVENILE BIPOLAR DISORDER
    Pablo Davanzo; Fiscal Year: 2002
    ..In addition to furthering the candidate's transition to independent research, the proposed study would also contribute to our knowledge of pharmacological treatment and possible neurobiological markers of juvenile bipolar disorder. ..
  44. EFFECTIVENESS OF NALTREXONE IN A COMMUNITY SETTING
    Kathleen Brady; Fiscal Year: 2001
    ....
  45. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2004
    ..abstract_text> ..
  46. AMLODIPINE TREATMENT FOR COCAINE DEPENDENCE
    Robert Malcolm; Fiscal Year: 2001
    ....
  47. Value of Technology to Transfer Discharge Information
    JAMES GRAUMLICH; Fiscal Year: 2006
    ..The cost outcome is the physician time required to use the discharge software. ..
  48. Planning Grant for CTSA at MUSC
    Kathleen Brady; Fiscal Year: 2006
    ..The development and subsequent implementation of the strategic plan has the potential to transform the research enterprise of MUSC and the state. [unreadable] [unreadable] [unreadable]..
  49. A Controlled Trial of NAC for Cocaine Dependence
    Robert Malcolm; Fiscal Year: 2009
    ..placebo;and 3) to study cocaine craving/cue reactivity and withdrawal symptoms in subjects taking NAC or placebo. ..
  50. CLINICAL INVESTIGATION OF DRUG ABUSE DISORDERS
    Kathleen Brady; Fiscal Year: 2008
    ..The candidate would also use the time and funding provided through this award to continue to expand her activities in mentoring fellows and junior faculty. ..
  51. HORMONE REPLACEMENT IN MENOPAUSAL WOMEN WITH EPILEPSY
    Cynthia Harden; Fiscal Year: 2002
    ..The outcome of this study will be determined by comparing seizure frequency in the baseline phase with the treated phase between placebo and hormone treated groups. ..