Genomes and Genes
Summary: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
Publications243 found, 100 shown here
- The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrineHua Yu
Institute of Chinese Medical Sciences, University of Macau, Macau SAR, PR China
J Pharm Biomed Anal 46:75-81. 2008The lipophilicity and solubility profiles of bis(12)-hupyridone (B12H) and bis(7)-tacrine (B7T), two novel acetylcholinesterase inhibitors dimerized from huperzine A fragments and tacrine, respectively, were investigated over a broad pH ..
- Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicityDaniel F Carr
Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK
Pharmacogenet Genomics 17:961-72. 2007b>Tacrine, an anticholinesterase used to treat Alzheimer's disease (AD), leads to an increase in serum alanine aminotransferase (ALT) levels. The factors determining individual susceptibility are largely unknown...
- Effect of tacrine on EEG slowing in the rat: enhancement by concurrent monoamine therapyH C Dringenberg
Department of Psychology, Queen s University, Kingston, Ontario, Canada
Neurobiol Aging 21:135-43. 2000..5-4 Hz) and theta (4-8 Hz) bands affected most severely. The acetylcholinesterase inhibitor tacrine, at doses between 10 and 20 mg/kg, reversed these EEG changes; co-administration of tacrine and the noradrenaline-..
- Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: involvement in hippocampal neuronal loss in Alzheimer's diseaseDesiree Antequera
Neuroscience Group, Instituto de Investigación Hospital 12 de Octubre I 12, Madrid, Spain
Neurobiol Dis 46:682-91. 2012..A multifunctional molecule, the hybrid tacrine-8-hydroxyquinoline (named IQM-622), displays cholinergic, antioxidant, copper-complexing and neuroprotective ..
- Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampusYeon Kye Kim
National Research Laboratory for Glycobiology NRLG, Korean Ministry of Science and Technology, Kyungju City, 780 714, Kyungbuk, South Korea
J Ethnopharmacol 87:149-54. 2003..the extracellular acetylcholine concentration in the hippocampus of rats were evaluated, and compared to that of tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride), a well-known and centrally acting acetylcholinesterase (AChE) ..
- Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidatesPelayo Camps
Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, and Institut de Biomedicina IBUB, Universitat de Barcelona, Av Diagonal 643, E 08028 Barcelona, Spain
Chem Biol Interact 187:411-5. 2010..Two novel families of dual binding site acetylcholinesterase (AChE) inhibitors have been developed, consisting of a tacrine or 6-chlorotacrine unit as the active site interacting moiety, either the 5,6-dimethoxy-2-[(4-piperidinyl)methyl]-..
- Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cellsMin Sup Lee
Department of Food Science and Nutrition, Pukyong National University, Busan 608 737, South Korea
J Agric Food Chem 60:5340-9. 2012..activities against 2,2-diphenyl-1-picrylhydrazyl and suppressed the intracellular reactive oxygen species in tacrine-treated HepG2 cells...
- Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db miceQi Zhao
Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
J Pharmacol Sci 117:230-42. 2011..KK (100 - 200 mg/kg per day) and the reference drug tacrine (THA: 2.5 mg/kg per day) ameliorated the performance of O-db/db mice without affecting their serum glucose level...
- Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrineLygia Azevedo Marques
VU University Amsterdam, Faculty of Sciences, Section of Biomolecular Analysis, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
J Pharm Biomed Anal 53:609-16. 2010The present paper describes a methodology for rapid assessment of chemical and biological degradation products of tacrine and their bioactivity for acetylcholinesterase (AChE)...
- Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in miceGunjan Saxena
Division of Pharmacology, Central Drug Research Institute, PO Box 173, Lucknow UP 226001, India
Eur J Pharmacol 581:283-9. 2008..Therefore, the present study was designed to investigate the influence of antidementia drugs, tacrine and donepezil, on biochemical markers of oxidative stress, glutathione (GSH) and malondialdehyde (MDA), and ..
- Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibitionSompop Bencharit
Department of Chemistry, School of Dentistry, University of North Carolina, Chapel Hill, 27599, USA
Chem Biol 10:341-9. 2003..We determined the 2.4 A crystal structure of hCE1 in complex with tacrine, the first drug approved for treating Alzheimer's disease, and compare this structure to the Torpedo californica ..
- New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection propertiesRafael Leon
Laboratorio de Radicales Libres IQOG, CSIC, C Juan de la Cierva 3, 28006 Madrid, Spain
Bioorg Med Chem 16:7759-69. 2008..In this communication, we describe the synthesis and biological evaluation of tacripyrimedones 1-5, a series of new tacrine-1,4-dihydropyridine hybrids bearing the general structure of 11-amino-12-aryl-3,3-dimethyl-3,4,5,7,8,9,10,12-..
- Intranasal mucoadhesive microemulsion of tacrine to improve brain targetingViral V Jogani
Technology Information Forecasting and Assessment Council TIFAC, Centre of Relevance and Excellence CORE in New Drug Delivery Systems NDDS, The Maharaja Sayajirao University of Baroda, Fatehganj, India
Alzheimer Dis Assoc Disord 22:116-24. 2008The aim of the investigation was to prepare and characterize microemulsion/mucoadhesive microemulsion of tacrine (TME/TMME), assess its pharmacokinetic and pharmacodynamic performances for brain targeting and for improvement in memory in ..
- Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticlesBarnabas Wilson
Department of Pharmaceutics, J S S College of Pharmacy, Ootacamund, Tamil Nadu, India
Eur J Pharm Biopharm 70:75-84. 2008The purpose of the present study was to investigate the possibility of targeting an anti-Alzheimer's drug tacrine in the brain using polymeric nanoparticles...
- Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesteraseL Savini
Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Aldo Moro, 53100, Siena, Italy
Bioorg Med Chem Lett 11:1779-82. 2001Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed...
- Highly selective inhibition of butyrylcholinesterase by a novel melatonin-tacrine heterodimersAnna Zawadzka
Faculty of Chemistry, University of Warsaw, Warsaw, Poland
J Pineal Res 54:435-41. 2013Novel inhibitors of cholinesterases, especially butyrylcholinesterase (BuChE), were obtained by coupling melatonin-tacrine heterodimers via the carbamate bond...
- Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmineQin Zhao
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
Eur J Pharmacol 455:101-7. 2002Five inhibitors of acetylcholinesterase, huperzine A, donepezil, tacrine, rivastigmine and physostigmine, were compared with regard to their effects on different molecular forms of acetylcholinesterase in cerebral cortex, hippocampus, ..
- Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organE Ros
Laboratori de Neurobiologia Cellular i Molecular, , Facultat de Medicina, Hospital de Bellvitge, Universitat de Barcelona, E-08907 L'Hospitalet de Llobregat, Spain
J Neurophysiol 86:183-9. 2001Bis(7)-tacrine is a potent acetylcholinesterase inhibitor in which two tacrine molecules are linked by a heptylene chain. We tested the effects of bis(7)-tacrine on the spontaneous synaptic activity...
- Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cellsH Cho
MRRC and College of Pharmacy, Wonkwang University, Iksan, Korea
Planta Med 67:750-1. 2001..compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of compounds 1 - 3 are 1.0, 47.0, 50...
- Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicityYuki Takada-Takatori
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
Eur J Pharmacol 549:19-26. 2006..mechanisms of the neuroprotective effects of two central-type acetylcholinesterase inhibitors, galanthamine and tacrine, on nitric oxide-mediated glutamate neurotoxicity using primary cultures from the cerebral cortex of fetal rats...
- Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybridsMaria del Mar Alcalá
Dpt de Farmacologia, de Terapeutica i de Toxicologia, Facultat de Medicina, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
Neuropharmacology 44:749-55. 2003The effects of two tacrine-huperzine A hybrids, (+/-)-huprine Y and (+/-)-huprine Z, have been evaluated. Bovine and human acetylcholinesterase (AChE) and human butyrylcholinesterase (BChE) inhibition were assayed by Ellman's method...
- Hepatoprotective compounds of the roots of Cudrania tricuspidata on tacrine-induced cytotoxicity in Hep G2 cellsRen Bo An
College of Pharmacy, Wonkwang University, Iksan, Korea
Biol Pharm Bull 29:838-40. 2006..9+/-1.5 microM, against tacrine-induced cytotoxicity in Hep G2 cells. Silybin as positive control showed an EC50 value of 84.76+/-0.5 microM...
- Electroencephalographic activation by tacrine, deprenyl, and quipazine: cholinergic vs. non-cholinergic contributionsHans C Dringenberg
Department of Psychology, Queen s University, K7L 3N6, Kingston, Ontario, Canada
Eur J Pharmacol 447:43-50. 2002..The acetylcholinesterase inhibitor tacrine (5-20 mg/kg) restored EEG activation in the low dose scopolamine group, but was less effective against the high ..
- Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChED Alonso
NeuroPharma, S A, Avda de la Industria 52, 28760 Tres Cantos Madrid, Spain
Bioorg Med Chem 13:6588-97. 2005A new series of donepezil-tacrine hybrid related derivatives have been synthesised as dual acetylcholinesterase inhibitors that could bind simultaneously to the peripheral and catalytic sites of the enzyme...
- Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cellsHyuncheol Oh
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Korea
Planta Med 68:748-9. 2002..Compounds 1 and 2 showed hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 and 2 were 20.6 +/- 1...
- Tacrine attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cellsRui Wang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, PR China
Brain Res Mol Brain Res 107:1-8. 2002The present studies investigated the effects of tacrine, a selective acetylcholinesterase (AChE) inhibitor and promising anti-dementia agent, on hydrogen peroxide (H(2)O(2))-induced apoptosis and the expression of apoptosis-related genes ..
- Nose-to-brain delivery of tacrineViral V Jogani
Department of Pharmacy, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Post Box No 51, Kalabhavan, Vadodara 390001, India
J Pharm Pharmacol 59:1199-205. 2007In the treatment of Alzheimer's disease tacrine, a cholinesterase inhibitor, is not the drug of choice due to its low oral bioavailability, extensive hepatic first-pass effect, rapid clearance from the systemic circulation, pronounced ..
- Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective propertiesMaría Isabel Fernández-Bachiller
Instituto de Química Médica, Consejo Superior de Investigaciones Cientificas CSIC, C Juan de la Cierva 3, 28006 Madrid, Spain
ChemMedChem 4:828-41. 2009b>Tacrine-melatonin hybrids were designed and synthesized as new multifunctional drug candidates for Alzheimer's disease...
- Tribuli fructus constituents protect against tacrine-induced cytotoxicity in HepG2 cellsErisa Byun
Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570 749, Korea
Arch Pharm Res 33:67-70. 2010..Compounds 1 and 3 showed significant hepatoprotective activities, with EC50 values of 13.46 +/- 0.2 and 7.06 +/- 0.7 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.
- Longitudinal changes in quantitative EEG during long-term tacrine treatment of patients with Alzheimer's diseaseV Jelic
Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, Huddinge University Hospital, Sweden
Neurosci Lett 254:85-8. 1998..In order to define the profile of EEG changes during tacrine long-term treatment, for 12 months we followed 15 AD patients receiving an optimal individually tolerable dose...
- Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimersStefano Rizzo
Max Planck Institut fur molekulare Physiologie, Abteilung Chemische Biologie, Otto Hahn Str 11, 44227 Dortmund, Germany
Eur J Med Chem 46:4336-43. 2011..This is the case of tacrine and its dimeric derivative bis(7)-tacrine which, for instance, paved the way for the development of a broad ..
- Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitorsHuang Tang
State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Chemical Engineering of Guangxi Normal University, Guilin 541004, PR China
Eur J Med Chem 46:4970-9. 2011..The new hybrids consist of a unit of 1-azabenzanthrone and a tacrine or its congener, connected through an oligomethylene linker containing an amine group at variable position...
- Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analoguesJ L Marco
Laboratorio de Radicales Libres CSIC, Madrid, Spain
Bioorg Med Chem 9:727-32. 2001..These molecules are tacrine-like analogues which have been prepared from readily available polyfunctionalized ethyl [6-amino-5-cyano-4H-..
- Alaternin and emodin with hydroxyl radical inhibitory and/or scavenging activities and hepatoprotective activity on tacrine-induced cytotoxicity in HepG2 cellsHyun Ah Jung
Research Institute of Marine Science and Technology, Korea Maritime University, Busan, 606 791, Korea
Arch Pharm Res 27:947-53. 2004..and emodin, to scavenge and/or inhibit hydroxyl radicals generated by the Fenton reaction and to protect tacrine-induced cytotoxicity in human liver derived HepG2 cells were evaluated, respectively...
- Tacrine derivatives-acetylcholinesterase interaction: 1H NMR relaxation studyMaurizio Delfini
Dipartimento di Chimica, Universita degli Studi La Sapienza, Piazzale Aldo Moro, 5 00185 Roma, Italy
Bioorg Chem 35:243-57. 2007Two acetylcholinesterase (AChE) inhibitors structurally related to Tacrine, 6-methoxytacrine (1a) and 9-heptylamino-6-methoxytacrine (1b), and their interaction with Electrophorus Electricus AChE were investigated...
- Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorgeEdwin H Rydberg
Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
J Med Chem 49:5491-500. 2006..X-ray crystal structures were solved for complexes with Torpedo californica acetylcholinesterase of two bivalent tacrine derivative compounds in which the two tacrine rings were separated by 5- and 7-carbon spacers...
- Homodimeric tacrine congeners as acetylcholinesterase inhibitorsMing Kuan Hu
School of Pharmacy and Department of Pharmacology, National Defense Medical Center, 161 Section 6, Minchuan East Road Taipei, Taiwan 114, Republic of China
J Med Chem 45:2277-82. 2002In the search for highly selective and potent derivatives of tacrine (1a), a number of homodimeric tacrine congeners were synthesized and conducted for their effects on rat acetylcholinesterase (AChE) and human butyrylcholinesterase (..
- Tacrine therapy is associated with reduced mortality in nursing home residents with dementiaBrian R Ott
Department of Clinical Neurosciences, Center for Gerontology and Health Care Research, and Department of Community Health, Brown University, Providence, Rhode Island
J Am Geriatr Soc 50:35-40. 2002To investigate the extent to which treatment with tacrine is associated with a reduction in mortality in nursing home residents with dementia.
- Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregationWen Luo
Sun Yat Sen University, Guangzhou, People s Republic of China
Bioorg Med Chem 19:763-70. 2011A new series of tacrine-multialkoxybenzene hybrids (9a-9n) were designed, synthesized and evaluated as dual inhibitors of cholinesterases (ChEs) and self-induced β-amyloid (Aβ) aggregation...
- Phenolic constituents of galla Rhois with hepatoprotective effects on tacrine- and nitrofurantoin-induced cytotoxicity in Hep G2 cellsRen Bo An
College of Pharmacy, Wonkwang University, Korea
Biol Pharm Bull 28:2155-7. 2005..39+/-5.4 and 29.51+/-0.7 microM, respectively, against tacrine-induced cytotoxicity, and 150.9+/-6.4 and 23.81+/-0...
- New tacrine-hydrazinonicotinamide hybrids as acetylcholinesterase inhibitors of potential interest for the early diagnostics of Alzheimer's diseaseP Szymanski
Department of Pharmaceutical Chemistry and Drug Analysis, Medical University, Lodz, Poland
Pharmazie 61:269-73. 2006..results of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by an affinity series of tacrine-hydrazinonicotinamide hybrids are described...
- NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicityLei Fang
Institute of Pharmacy, Friedrich Schiller University Jena, D 07743 Jena, Germany
J Med Chem 51:7666-9. 2008A series of tacrine-NO donor hybrid compounds are synthesized and evaluated for cholinesterase inhibitory activity, cognition improving activity, and hepatotoxicity...
- Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptorsLei Fang
Center of Drug Discovery, China Pharmaceutical University, 210009 Nanjing, PR China
J Med Chem 53:2094-103. 2010..M(1) muscarinic receptor agonist xanomeline and the cholinesterase inhibitor and allosteric receptor modulator tacrine were prepared with varying spacer length of 10-17 atoms...
- Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitrilesAbdelouahid Samadi
Laboratorio de Radicales Libres y Química Computacional IQOG, CSIC, C Juan de la Cierva 3, 28006 Madrid, Spain
Bioorg Med Chem 19:122-33. 2011The synthesis, biological assessment, and molecular modelling of new tacrine analogues 11-22 is described...
- A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's diseaseCarlos Spuch
Neuroscience Laboratory, University Hospital, 12 de Octubre Research Center, 28041 Madrid, Spain
Neurotox Res 17:421-31. 2010..Emerging evidence indicates that antioxidants could be useful either for the prevention or treatment of AD. Tacrine and melatonin are well-known drugs which act as an acetylcholinesterase inhibitor and a free radical scavenger, ..
- Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactionsP R Carlier
Department of Chemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
J Med Chem 42:4225-31. 1999Dimeric acetylcholinesterase (AChE) inhibitors containing a single 9-amino-1,2,3,4-tetrahydroacridine (tacrine) unit were constructed in an effort to further delineate structural requirements for optimal binding to the AChE peripheral ..
- Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatmentA Minarini
Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Neuropharmacology 62:997-1003. 2012..The structure of tacrine, an acetylcholinesterase (AChE) inhibitor (AChEI), has been widely used as scaffold to provide new MTDLs...
- Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damageJia Hua Fang
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
BMC Neurosci 11:31. 2010..Bis(7)-tacrine is a noncompetitive NMDA receptors antagonist that can prevent glutamate-induced hippocampal neurons damage...
- Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analoguesCarla Martins
Research Institute for Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Av Prof Gama Pinto, 1649 003 Lisbon, Portugal
Eur J Med Chem 46:6119-30. 2011..Thus, we synthesized diversely substituted tacrine analogues 1-11 and 12-16 by Friedländer-type reaction of readily available o-amino(furano/pyrrolo)nitriles with ..
- Shuttle-box avoidance learning in mice: improvement by combined glucose and tacrineF Pavone
Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy
Neurobiol Learn Mem 69:204-10. 1998Glucose and the acetylcholinesterase inhibitor tacrine were tested, alone and in combination, in mice of the CD-1 strain subjected to five daily shuttle-box training sessions...
- The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cellsD K Lahiri
Institute of Psychiatric Research, Departments of Psychiatry and Neurology, 791 Union Drive, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Brain Res Mol Brain Res 62:131-40. 1998..b>Tacrine, a cholinesterase inhibitor, has been shown to improve memory and cognitive functions in some patients with AD, ..
- Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidatesLei Fang
Lehrstuhl fur Pharmazeutische Medizinische Chemie, Institut fur Pharmazie, Friedrich Schiller Universitat Jena, Philosophenweg 14, D 07743 Jena, Germany
Bioorg Med Chem Lett 18:2905-9. 2008Five tacrine-ferulic acid hybrids (6a-e) were designed and synthesized as multi-potent anti-Alzheimer drug candidates...
- Tacrine-NO donor and tacrine-ferulic acid hybrid molecules as new anti-Alzheimer agents: hepatotoxicity and influence on the cytochrome P450 system in comparison to tacrineAmelie Lupp
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Germany
Arzneimittelforschung 60:229-37. 2010b>Tacrine (CAS 321-64-2) is a reversible acetylcholine esterase inhibitor that, despite exerting beneficial effects on Alzheimer's disease (AD), displays marked hepatotoxicity...
- Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cellsHyuncheol Oh
Planta Med 68:463-4. 2002..0 +/- 3.4 microM. Comparison of hepatoprotective activities for six furocoumarins 1 - 6 suggested that oxy-substitution at the C-9 position increased the hepatoprotective activity...
- Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neuronsHongjun Fu
Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
J Proteome Res 6:2435-46. 2007..In this study, post-treatment of cerebellar granule neurons with bis(7)-tacrine significantly reversed declines in mitochondrial membrane potential, ATP production, and neuronal cell death ..
- Delayed evacuatory function due to specific smooth muscle reactivity in the gastrointestinal tracts of tacrine-treated ratsA Krustev
Department of Biophysics, Medical University, Plovdiv, Bulgaria
Pharmacology 81:50-6. 2008Most of the side effects induced by tacrine are associated with the gastrointestinal (GI) tract...
- Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing propertiesMaría Isabel Fernández-Bachiller
Instituto de Química Médica, Consejo Superior de Investigaciones Cientificas CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
J Med Chem 53:4927-37. 2010b>Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit cholinesterases and decrease beta-amyloid (Abeta) levels by complexation of redox-active metals, respectively...
- Tacrine derivatives and Alzheimer's diseaseV Tumiatti
Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Curr Med Chem 17:1825-38. 2010..b>Tacrine was the first AChEI introduced in therapy...
- Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairmentM J M Ezoulin
Unité de Pharmacochimie Moléculaire et Systèmes Membranaires EA2381, Universite Paris 7 Denis Diderot, Case 7066, 2, place Jussieu, 75251 Paris Cedex 05, France
Toxicol In Vitro 20:824-31. 2006Acetylcholinesterase inhibitors are commonly used as cognitive enhancers for dementia in aged people. Among them, tacrine (THA) but not galanthamine, was shown to exhibit hepatotoxicity which reduces its clinical use...
- Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptorsWenming Li
Department of Biochemistry and Biology, Hong Kong University of Science and Technology, Kowloon, Hong Kong
J Biol Chem 280:18179-88. 2005The neuroprotective properties of bis(7)-tacrine, a novel dimeric acetylcholinesterase (AChE) inhibitor, on glutamate-induced excitotoxicity were investigated in primary cultured cerebellar granule neurons (CGNs)...
- Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targetsWenming Li
Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Hong Kong SAR, China
Neurotherapeutics 6:187-201. 2009..decade, our group has developed several series of dimeric acetylcholinesterase (AChE) inhibitors derived from tacrine and huperzine A, a unique anti-Alzheimer's drug originally discovered from a traditional Chinese medicinal plant...
- The apolipoprotein E epsilon4 allele and the response to tacrine therapy in Alzheimer's diseaseA S Rigaud
Hopital Broca, 54 56 Rue Pascal, 75013, Paris, France
Eur J Neurol 7:255-8. 2000..of our study was to evaluate the effects of the apolipoprotein E (ApoE) phenotype and gender on the response to tacrine treatment in Alzheimer's disease (AD). ApoE phenotyping was performed on 76 patients treated with tacrine for AD...
- Dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block L-type Ca(2+) channelsN N Lermontova
Department of Biological Research, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region
Bull Exp Biol Med 132:1079-83. 2001..Antialzheimer preparations tacrine and dimebon improve survival of cerebellar granule cells during long-term incubation with Abeta25-35, the ..
- Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotypeM Sjogren
Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, Sweden
J Neural Transm 108:451-8. 2001..To investigate the relation between tacrine treatment, inheritance of ApoE epsilon4 alleles, and rate of progression, the differences in MMSE and CIBIC ..
- Investigation into the in vivo effects of five novel tacrine/ferulic acid and beta-carboline derivatives on scopolamine-induced cognitive impairment in rats using radial maze paradigmChristian Fleck
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Germany
Arzneimittelforschung 60:299-306. 2010Two tacrine-ferulic acid hybrids (1 A, 1 B) and three beta-carboline derivatives (BCs; 2A, 2B, 2C) were tested in vivo on 3-month-old female rats as multi-potent anti-Alzheimer drug candidates...
- Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in ratsP Chopin
Centre de Recherche Pierre Fabre, Castres, France
Psychopharmacology (Berl) 106:26-30. 1992..b>Tacrine or galanthamine, inhibitors of acetylcholinesterase, given in conjunction with scopolamine partially reversed the ..
- Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effectHideto Miwa
Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
Parkinsonism Relat Disord 15:30-5. 2009To examine the mechanisms underlying the anti-tremor effect of zonisamide in rats under conditions of tacrine-induced tremulous jaw movements (TJMs).
- Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activityHongjun Fu
Department of Biochemistry, The Hong Kong University of Science and Technology, Hong Kong, China
Biochem Biophys Res Commun 366:631-6. 2008..In this study, the effect and mechanisms of bis(7)-tacrine (a promising anti-Alzheimer's dimer) on Abeta generation were investigated. Bis(7)-tacrine (0...
- Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c miceHina Mehta
Division of Clinical and Experimental Neurosciences, Indian Institute of Chemical Biology, Jadavpur, Calcutta
Behav Brain Res 163:227-36. 2005b>Tacrine is a potent and reversible inhibitor of acetylcholinesterase (AChE) in the brain. It produces tremor in animals, which is believed to be due to an increase in the brain acetylcholine level following AChE inhibition...
- Tacrine-induced liver damage: an analysis of 19 candidate genesAna Alfirevic
Department of Pharmacology and Therapeutics, The University of Liverpool, Sherrington Building, Ashton Street, Liverpool, UK
Pharmacogenet Genomics 17:1091-100. 2007b>Tacrine, the first acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease, is associated with transaminase elevation in up to 50% of patients...
- Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regionsNicola Simola
Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, 09124, Cagliari, Italy
Exp Neurol 189:182-8. 2004Acute administration of the acetylcholinesterase inhibitor tacrine to rats induces tremulous jaw movements which can be used as a valuable model of parkinsonian tremor...
- East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine AW M Li
Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China
Curr Alzheimer Res 4:386-96. 2007..The novel dimers, derived from tacrine and the fragment of huperzine A (HA'), have been demonstrated to be potent and selective reversible inhibitors of ..
- Choline pivaloyl ester strengthened the benefit effects of Tacrine and Galantamine on electroencephalographic and cognitive performances in nucleus basalis magnocellularis-lesioned and aged ratsV Rispoli
Department of Pharmacobiological Sciences, University Magna Graecia of Catanzaro, Complesso Nini Barbieri, I 88021 Roccelletta di Borgia CZ, Italy
Pharmacol Biochem Behav 84:453-67. 2006..2,2-dimethylpropionate (choline pivaloyl ester) (CPE) and the Cholinesterase inhibitors (ChEIs) Tacrine (THA) and Galantamine (GAL)...
- Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrineHans Basun
Department of Neurotec, Karolinska Institutet, Huddinge University Hospital, Sweden
Dement Geriatr Cogn Disord 14:156-60. 2002..could change the levels of Abeta in plasma, we measured Abeta42 and Abeta40 plasma levels in AD subjects before tacrine treatment and at weeks 2 and 6 of treatment...
- Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's diseaseP Camps
Laboratori de Química Farmacèutica, Facultat de Farmacia, Universitat de Barcelona, Av Diagonal 643, E 08028, Barcelona, Spain
Mini Rev Med Chem 1:163-74. 2001b>Tacrine-huperzine A hybrids (huprines) are a new class of very potent and selective acetylcholinesterase (AChE) inhibitors. Huprines were designed from tacrine and (-)-huperzine A through a conjunctive approach...
- (+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alterationE G Jordà
Unitat de Farmacologia i Farmacognosia, Barcelona, Spain
J Alzheimers Dis 6:577-83; discussion 673-81. 2004..b>Tacrine, (-)-huperzine A and (+/-)-huprine Y, the AChEI tested in the study, did not reverse the loss of neuronal ..
- Action of tacrine on muscarinic receptors in rat intestinal smooth muscleM A Becerra
, Facultad de Farmacia, Universidad de Sevilla, , 41012 Sevilla, Spain
J Auton Pharmacol 21:113-9. 20011. The reversible cholinesterase inhibitor, tacrine (THA) was examined against the contractions of rat duodenum to acetylcholine and carbachol (cholinesterase resistant). 2...
- Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's diseaseJiri Patocka
Center of Advanced Studies, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
Curr Drug Metab 9:332-5. 2008b>Tacrine belongs to the group of acetylcholinesterse (AChE) inhibitors used as drugs for treatment of Alzheimer's disease (AD)...
- Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemiaYuming Zhao
Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong SAR, China
Neurosci Lett 439:160-4. 2008Bis(7)-tacrine, a promising anti-Alzheimer's dimer, has been shown to have multiple neuroprotective activities in vitro. Here, we investigate whether bis(7)-tacrine attenuates focal cerebral ischemic impairment in vivo...
- Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studiesYu Wei Liu
Department of Neurobiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Neuropharmacology 54:1086-94. 2008Bis(7)-tacrine is a novel dimeric acetylcholinesterase inhibitor derived from tacrine, and has been proposed as a promising agent to treat Alzheimer's disease...
- Actions of tacrine and galanthamine on histamine-N-methyltransferaseO D Taraschenko
Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Methods Find Exp Clin Pharmacol 27:161-5. 2005..The AD medication tacrine was previously shown to inhibit some forms of rodent histamine-N-methyltransferase (HNMT), but the effects of AD ..
- Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat bloodHua Yu
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, PR China
J Pharm Biomed Anal 44:1133-8. 2007..mass spectrometry with electrospray ionization was developed and applied for the quantification of bis(7)-tacrine (B7T) in rat blood...
- Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: an event-related potential studyC Engeland
Department of Psychiatry and Psychology, University of Western Ontario, London, ON, Canada
Pharmacol Biochem Behav 72:457-64. 2002..Thirteen patients with Alzheimer's disease (AD), 6 receiving treatment with the cholinesterase inhibitor, tacrine [tetrahydroaminoacridine (THA)], and 7 receiving no treatment, were administered 2 mg of nicotine polacrilex and ..
- Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liverAbdellah Mansouri
INSERM Unité 481, Faculte de Medecine Xavier Bichat, Paris, France
Hepatology 38:715-25. 2003..After several weeks of treatment, levels of alanine aminotransferase (ALT) increase in 50% of patients treated with tacrine for Alzheimer's disease. We looked for progressive effects on DNA to explain delayed toxicity...
- New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrineMiroslav Pohanka
Center of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
Neuro Endocrinol Lett 29:755-8. 2008..The first was commercialized drug tacrine (known also as Cognex) used for treatment of cognitive manifestation of Alzheimer\'s disease (AD)...
- Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channelsHongjun Fu
Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, P R China
J Neurochem 98:1400-10. 2006..In the current study, we investigated the effects of bis(7)-tacrine, a novel dimeric AChE inhibitor, on Abeta-induced neurotoxicity in primary cortical neurons...
- Quantitative structure-activity relationship (QSAR) of tacrine derivatives against acetylcholinesterase (AChE) activity using variable selectionsMankil Jung
Department of Chemistry, Yonsei University, Seoul 120 749, Republic of Korea
Bioorg Med Chem Lett 17:1082-90. 2007A diverse approach to the quantitative structure-activity relationship (QSAR) of tacrine derivatives against acetylcholinesterase (AChE) activity was studied using variable selections of stepwise multiple linear regression (MLR), genetic ..
- Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptorsYu Wei Liu
Wuhan Institute of Neuroscience and Drug Research, Jianghan University, Wuhan 430056, PR China
Biochem Biophys Res Commun 369:1007-11. 2008We have recently reported that bis(7)-tacrine could prevent glutamate-induced neuronal apoptosis through NMDA receptors. In this study, we demonstrated that in cultured rat cortical neurons, bis(7)-tacrine (IC(50), 0...
- Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currentsJialie Luo
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China
Biochem Biophys Res Commun 361:505-9. 2007Bis(7)-tacrine has been shown to prevent glutamate-induced neuronal apoptosis by blocking NMDA receptors. However, the characteristics of the inhibition have not been fully elucidated...
- Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicityT Simon
Pharmacology Department, INSERM SC4, Saint Antoine University, Paris, France
Clin Pharmacol Ther 67:432-7. 2000Glutathione conjugation of tacrine reactive metabolites depends in part on the activity of glutathione-S-transferases (GST), of which two isozymes (GST M1 and GST T1) are polymorphically expressed.
- Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometryLi Zhang
Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, SAR, People s Republic of China
Biomed Chromatogr 22:414-20. 2008The current study aims to develop a specific and sensitive LC-MS/MS method for determination of bis(7)-tacrine (B7T) in rat plasma. A 100 microL plasma sample was extracted with ethyl acetate...
- Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthaseWenming Li
Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
Mol Pharmacol 71:1258-67. 2007..the NO synthase (NOS) inhibitor, N(G)-monomethyl-L-arginine (L-NMMA), and the NMDAR antagonist memantine, bis(7)-tacrine was found to be more potent in reducing NO-mediated excitotoxicity and the release of NO caused by glutamate...
- Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrineWenming Li
Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
Neuroreport 17:471-4. 2006Here we report that bis(7)-tacrine, a novel acetylcholinesterase inhibitor, exerts neuroprotective effects by inhibition of nitric oxide synthase...
- Controlled release tacrine delivery system for the treatment of Alzheimer's diseaseQ Yang
College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, USA
Drug Deliv 8:93-8. 2001..b>Tacrine is one of the three drugs approved by the FDA for the treatment of Alzheimer's disease...
- SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analoguesM Recanatini
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, I 40126 Bologna, Italy
J Med Chem 43:2007-18. 2000..to derive a comprehensive SAR picture for the class of acetylcholinesterase (AChE) inhibitors related to tacrine, a drug currently in use for the treatment of the Alzheimer's disease...
- Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant propertiesMaría Isabel Rodríguez-Franco
Instituto de Quimica Medica CSIC, 28006 Madrid, Spain
J Med Chem 49:459-62. 2006b>Tacrine and melatonin are well-known drugs with activities as an acetylcholinesterase (AChE) inhibitor and free radical scavenger, respectively...
- The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the ratC Ibebunjo
Department of Anaesthesia, Royal Victoria Hospital and McGill University, Montreal, Quebec, Canada
Anesth Analg 85:431-6. 1997b>Tacrine (THA) is an anticholinesterase drug used to manage Alzheimer's dementia, but it is not clear how its chronic use might affect response to nondepolarizing muscle relaxants...
- Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in miceS Y Pan
Department of Biochemistry, Hong Kong University of Science and Technology, China
Planta Med 68:217-20. 2002Intragastric administration (100-200 micromol/kg) of tacrine (THA) or bis(7)-THA could cause an acute and dose-dependent increase in plasma alanine aminotransferases activity in mice at 6 h after the drug administration...
- Effect of tacrine on intracellular calcium in cholinergic SN56 neuronal cellsV Dolezal
Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska, Prague
Brain Res 769:219-24. 1997..We have found earlier that the depolarization-induced release of acetylcholine from the brain could be inhibited by tacrine (tetrahydroaminoacridine) but the mechanism of this action of tacrine was not clarified (S. Tucek, V. Dolezal, J...
- New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's diseaseP Camps
Laboratori de Quimica Farmaceutica and Departament de Fisico Quimica, Facultat de Farmacia, Universitat de Barcelona, Av Diagonal 643, E 08028 Barcelona, Spain
J Med Chem 43:4657-66. 2000Several new 12-amino-6,7,10,11-tetrahydro-7, 11-methanocycloocta[b]quinoline derivatives (tacrine-huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors...
- Combined tacrine and estrogen replacement therapy in patients with Alzheimer's diseaseL S Schneider
Department of Psychiatry, School of Medicine, Los Angeles, California, USA
Ann N Y Acad Sci 826:317-22. 1997..possible effects of estrogen replacement therapy (ERT) on clinical response to the cholinesterase inhibitor tacrine in women with Alzheimer's disease (AD)...
- Persistent Attenuation of Cocaine-Reinforced BehaviorKENNETH W GRASING; Fiscal Year: 2013..Cholinesterase inhibitors such as tacrine increase synaptic levels of ACh by preventing its inactivation by AChE or BuChE, and can improve learning and ..
- Tacrine Effects on Cocaine Self-Administration and Pharmacokinetic MeasuresKENNETH W GRASING; Fiscal Year: 2012..Cholinesterase inhibitors such as tacrine increase synaptic levels of ACh by preventing its inactivation by acetylcholinesterase (AChE) or ..
- Determining Therapeutic Efficacy of AGE in ADNeelima Chauhan; Fiscal Year: 2005..and cholinergic system regulate APP processing, current Alzheimer's therapy targets cholinergic enhancement [Tacrine, Aricept/Donezepil, Rivastigmine, Galantamine]; and regulation of inflammation by NSAIDs [Aspirin, Ibuprofen, ..
- MOTOR EFFECTS OF ATYPICAL ANTIPSYCHOTICSJohn Salamone; Fiscal Year: 2003..In addition, clozapine acts to suppress the jaw movements induce by the anticholinesterase tacrine. The suppression of tacrine-induced jaw movements by clozapine occurs at a relatively low dose; clozapine ..
- RECEPTOR/G-PROTEIN COUPLING IN ALZHEIMER'S DISEASEJohn Lee; Fiscal Year: 2001..g. bethanechol) or enhance the synaptic availability of acetylcholine (e.g. tacrine, arecept)...
- PSYCHOSIS IN ALZHEIMERS DISEASEJason Olin; Fiscal Year: 2000..pathology will enter a 4-week parallel-group, randomized, placebo controlled trial of a cholinesterase inhibitor (tacrine) to test for a differential response in sensitivity. 2...
- NEUROMODULATORY ROLES OF MUSCARINIC RECEPTOR SUBTYPESP Conn; Fiscal Year: 2000..Furthermore, a compound that inhibits Ach metabolism, termed tacrine, is the only approved treatment for AD...
- Pharmacotherapy for Minor DepressionRobert Howland; Fiscal Year: 2004..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
- FMRI in Pre-Symptomatic PS1-related Alzheimer's DiseaseJohn Ringman; Fiscal Year: 2005..UCI, with its strong dementia research program, growing MRI capabilities and opportunity to collaborate at the nearby UCLA Brain Imaging Center, is an excellent environment for this endeavor. ..
- SOCIAL FACTORS AND EPIDEMIOLOGY OF COGNITIVE DECLINEMarie Florence Shadlen; Fiscal Year: 2005..Hence, these projects will allow Dr Shadlen to achieve her 5-year goal of synthesis of her interests in racial differences, dementia, and epidemiology into an independent, thought-provoking research program. ..
- 1H MRSI/Response Inhibition/Methamphetamine AbusersJOSEPH O NEILL; Fiscal Year: 2005..This project will examine the chemistry of parts of the brain thought to be responsible for inhibition and/or damaged by methamphetamine in methamphetamine addicts. ..
- Ion Channels and Chemicals Controlling Synapse StabilityJoseph McArdle; Fiscal Year: 2006..The knowledge gained from this research will enlighten future molecular approaches to treating pathologies which afflict children and adults. ..
- Magnetic Resonance Spectroscopic Imaging of the Brain in Methamphetamine AbuseJOSEPH O NEILL; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- NEURAL CIRCUITRY MEDIATING SUCROSE INDUCED ANALGESIAMatthew Ennis; Fiscal Year: 2003..This work will lead to a better understanding of neural circuits controlling taste and pain and how these circuits regulate analgesia in newborns. ..
- CANDIDATE GENES FOR ALZHEIMER'S DISEASE RISK IN BLACKSRebecca Evans; Fiscal Year: 2005..This career enhancement plan will enable Dr. Evans to develop expertise in patient-oriented research, and help her accomplish her goal of becoming an independent investigator. ..